In this paper, we present several lines of evidence that cyclic guanosine 3':5'-monophosphate (cGMP) is involved in the photic entrainment pathway. (elsevierpure.com)
Light increases the level of cGMP in eyes without having detectable effects on cyclic adenosine 3':5' -monophosphate (cAMP). (elsevierpure.com)
the phase response curves for light and for 8-bromo cGMP are indistinguishable. (elsevierpure.com)
Neither 8-bromo cAMP nor 8-bromo 5'-GMP mimics the effect of light or of 8-bromo cGMP on the rhythm. (elsevierpure.com)
Light and 8-bromo cGMP appear to use convergent mechanisms for entrainment since the effects of these two treatments are nonadditive. (elsevierpure.com)
Finally, the kinetics of phase shifting by 8-bromo cGMP are similar to the kinetics of phase shifting by light. (elsevierpure.com)
In addition to perturbing the circadian rhythm, 8-bromo cGMP increases the frequency of spontaneous optic nerve impulses. (elsevierpure.com)
The pattern of nerve impulses during 8-bromo cGMP treatment is the same as the pattern of impulses produced by light. (elsevierpure.com)
The excitatory effect of 8-bromo cGMP, the lower Na + blockade of the effects of 8-bromo cGMP, and the involvement of membrane depolarization in phase shifting by light suggest that depolarization mediates the effect of 8-bromo cGMP on the rhythm. (elsevierpure.com)
The cellular site at which 8-bromo cGMP acts remains to be determined. (elsevierpure.com)
However, 8-bromo cGMP does not appear to affect the rhythm by acting on R-type photoreceptors in the eye since 8-bromo cGMP had no effect on the membrane potential of these photoreceptors. (elsevierpure.com)
The ZnPP-induced choleresis coincided with a reduction of tissue guanosine 3',5'-cyclic monophosphate (cGMP) levels and a decrease in vascular conductance. (elsevierpure.com)
The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases or disorders which are associated with a disturbed cGMP balance. (justia.com)
Phosphodiesterase2
It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase. (ouhsc.edu)
2. Benau D., Szabo E.I., Terner C. Endogenous inhibitors of cyclic adenosine 3',5'-monophosphate-phosphodiesterase in rat epididymis. (abvpress.ru)
Nucleotide3
Epac2, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rap1, is activated by adenosine 3',5'-monophosphate. (nbrp.jp)
Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. (biolog.de)
Synthesis of 8-hydroxy and 8-mercapto derivatives of acyclic adenine nucleoside and nucleotide analogs. (cas.cz)
Receptors1
Caffeine is an antagonist at adenosine receptors, which tells us that adenosine is important in the regulation of vigilance. (heresy.is)
Synthesis1
Synthesis of 8-bromo-4-imino-7,9-dimethylpyrido[3,2:4,5]thieno[3,2-d]pyrimidin-3(4H)-amine (5) Compound 4 (0.67?g, 0.002?mol) was mixed with hydrazine hydrate Troxerutin supplier (99%, 6?ml) in total ethanol (10?ml). (cell-signaling-pathways.com)
Activator2
PKA activator 8-bromo-cAMP and PKC activator phorbol-12, 13-didecanoate appeared to rapidly elevate both protein and mRNA levels and promoter activation of RGS2 gene. (nycu.edu.tw)
However, the sustained effect of both AVP and its putative second messenger, cyclic adenosine monophosphate (cAMP), on Na+ transport in the rabbit CCD is inhibitory. (jci.org)
8-chlorophenylthio-cAMP (8CPTcAMP) and 8-bromo-cAMP (8-Br-cAMP) also increased CCD [Ca++]i. (jci.org)
The growth-promoting action of Gsalpha-QL could not be mimicked by either 8-bromo cAMP or forskolin. (unm.edu)
Cells exposed to 8-Br-cAMP also inhibited TGFα-stimulated c-fos expression. (tmu.edu.tw)
These novel molecules outperform the benchmark PAM, 4-(3-( b enzyloxy)phenyl)-2-( e thylsulfinyl)-6-( t rifluoro-methyl) p yrimidine ( BETP ), and show Ca 2+ versus cyclic adenosine monophosphate (cAMP) signal bias. (wiley.com)
Membrane permeability comparable to 8-Br-cAMP. (biolog.de)
Although 8 bromo cAMP or forskolin modestly enhanced POMC transcription (2.8-fold), LIF markedly potentiated (7.4-fold) these cAMP activators. (manchester.ac.uk)
The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
Pathways1
6. Mewe M., Bauer C.K., Müller D., Middendorff R. Regulation of spontaneous contractile activity in the bovine epididymal duct by cyclic guanosine 5'-monophosphate-dependent pathways. (abvpress.ru)
Protein1
Consistent with the condensation defects, a chromosome structure protein complex, condensin II7,8, was reduced on hybrid oocyte chromosomes. (bvsalud.org)
Intracellular1
Cyclic AMP (slide 7.5.4 )and cyclic GMP (slide 9.3.6 ) function as intracellular second messengers. (heresy.is)
Cells1
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. (ouhsc.edu)
People2
This graph shows the total number of publications written about "8-Bromo Cyclic Adenosine Monophosphate" by people in this website by year, and whether "8-Bromo Cyclic Adenosine Monophosphate" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "8-Bromo Cyclic Adenosine Monophosphate" by people in Profiles. (ouhsc.edu)
Transport1
Feedback inhibition of cyclic adenosine monophosphate-stimulated Na+ transport in the rabbit cortical collecting duct via Na(+)-dependent basolateral Ca++ entry. (jci.org)
Effect1
We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
Journal2
Journal of Clinical Investigation , 97 (8), 1852-1859. (manchester.ac.uk)
In: Journal of Chemical Sciences, 87 (8). (iisc.ac.in)
Treatment1
Treatment with 1 μM 8- bromoguanosine 3',5'-cyclic monophosphate (8-BrcGMP) partly attenuated the ZnPP-induced choleresis in concert with repression of vascular conductance. (elsevierpure.com)
Epidermal growth1
11. Partial hydatidiform moles have impaired differentiated function (human chorionic gonadotropin and human placental lactogen secretion) in response to epidermal growth factor and 8-bromo-cyclic adenosine monophosphate. (nih.gov)
Guanosine monophosphate2
A vast number of studies have focused on understanding the nitric oxide (NO) signaling pathway, which culminates with the phosphorylation of the transcription factor cAMP-responsive element-binding protein (CREB) through the increase of the second messenger cyclic guanosine monophosphate (cGMP) and activation of cGMP-dependent protein kinase. (intechopen.com)
This treatment did not, however, inhibit protein synthesis or stimulation of arylalkylamine N-acetyltransferase (NAT) activity produced by treatment with either DB-cyclic AMP (N6,2'-O-dibutyryl adenosine 3',5' monophosphate) or 8 Br-cyclic AMP, stable cyclic AMP derivatives. (nih.gov)
Membrane-permeant cAMP derivatives (dibutyryl- and 8-bromo-cAMP) increase gap-junctional conductance within minutes when applied to voltage-clamped pairs of rat hepatocytes. (elsevierpure.com)
19862
Proceedings of the National Academy of Sciences of the United States of America , Vol. 83, No. 8, 1986, p. 2473-2477. (elsevierpure.com)
Thus, in view of the putative role of cyclic AMP as an inhibitory second messenger in these cells, PDE IV inhibitors have been shown to suppress inflammatory cell activity. (nih.gov)
Expression1
8. [Changes in gene expression profiles of hydatidiform mole and choriocarcinoma as compared with trophoblast hyperplasia]. (nih.gov)
Cells3
Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin. (nih.gov)
Treatment of fasciculata and glomerulosa cells with 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in small increases in CYP1B1 activity (1.8- and 2.5-fold, respectively), but much larger increases (5- and 6-fold, respectively) in CYP1B1 at the mRNA level 2,3,7,8-Tetrachlorodibenzo-p-dioxin had no effect in the presence of ACTH stimulation. (nih.gov)
[ 8 ] indicated that the histone deacetylase inhibitor depsipeptide enhances apoptotic killing by p53 gene transfer in anaplastic thyroid cancer cell lines (FRO and WRO cells), suggesting that this combination treatment strategy might also be useful in the treatment of undifferentiated thyroid carcinomas. (medscape.com)
Increase1
The 48-h CT treatment increased cyclic AMP accumulation 10- to 17-fold but blocked the norepinephrine (NE)-induced increase in cyclic AMP accumulation, presumably reflecting the loss of Gs alpha. (nih.gov)
Type1
Nevertheless, as the type from the attenuation provides yet to become defined, LVS continues to be unlicensed, meaning there is absolutely no certified vaccine open to drive back (8, 9). (immune-source.com)
Study1
An equilibrium study of the cooperative binding of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate to the adenosine cyclic 3',5'-monophosphate receptor protein from Escherichia coli. (nih.gov)