AnatomiaOrganismiMalattieSostanze chimiche e FarmaciTecniche ed apparecchiature analitiche, diagnostiche e terapeutichePsichiatria e PsicologiaScienze biologicheScienze naturaliAssistenza sanitaria
AdenosinaRecettore Dell' Adenosina A2ARecettore Dell' Adenosina A1Adenosine A2 Receptor AntagonistsPurinergic P1 Receptor AntagonistsAdenosina DeaminasiAdenosine A1 Receptor AntagonistsInterleukin 1 Receptor Antagonist ProteinRecettore Dell' Adenosina A3Recettore Dell' Adenosina A2BNeurokinin-1 Receptor AntagonistsRecettori Dell'Adenosina A2Adenosina ChinasiRecettori Purinergici P1Adenosine A2 Receptor AgonistsXantineAdenosine A1 Receptor AgonistsRelazione Farmacologica Dose-RispostaRats, Sprague-DawleyPurinergic P1 Receptor AgonistsAntagonisti Dell'Istamina H2PiperidineSerotonin 5-HT3 Receptor AntagonistsAntagonisti Degli Aminoacidi CatalizzatoriAdenosine A3 Receptor AntagonistsAntagonisti Della DopaminaAngiotensin Receptor AntagonistsSerotonin 5-HT2 Receptor AntagonistsAntagonisti Degli OrmoniPurinergic P2 Receptor AntagonistsAdenosina MonofosfatoRats, WistarAdenosina-5'-(N-Etilcarbossamide)TeofillinaAntagonisti NarcoticiAntagonisti Dell'Istamina H1Recettori Delle EndotelineRecettori PurinergiciAntagonisti MuscariniciGABA-A Receptor AntagonistsFenetilamineAntagonisti Dell'IstaminaAntagonisti Dell'Acido Gamma Amino ButirricoAntagonisti Della SerotoninaAntagonisti Dei LeucotrieniSialoglicoproteineRecettore Dell' Endotelina ARecettori Della SerotoninaRecettori Del N-Metil-D-AspartatoAmp CiclicoCavieDizocilpina MaleatoSerotonin 5-HT1 Receptor Antagonists2-CloroadenosinaComposti Di BifenileDosaggio Di RadioligandiAdenosine A3 Receptor AgonistsRecettori Per L'Interleuchina-1TetrazoliAdrenergic alpha-1 Receptor AntagonistsBenzoazepineFenilisopropiladenosinaCellule ColtivateAntagonisti NicotiniciPurinergic AntagonistsPirazoliPiridineAdrenergic alpha-2 Receptor AntagonistsSerotonin Receptor AgonistsHistamine H3 AntagonistsSulfonamidi5'-NucleotidasiInosinaPeptidi CicliciIndoliSerotoninaLegame CompetitivoFattori TemporaliPurinergic P2X Receptor AntagonistsAzepineLosartanSostanza PGABA-B Receptor AntagonistsTeobrominaInterazioni FarmacologicheRecettori Delle BradichinineEndothelin-1Calcio (Chim)TriazineCimetidinaRecettori Della Neurochinina-1Recettore Dell' Endotelina BTriazoliNeuroniComportamento AnimaleRecettori Della Dopamine D2PiperazineDevazepideRecettori Delle ColecistochininePirrolidine
ReceptorsClass
Receptors4
  • Depending on substitutions on some key positions of their scaffold they show selectivity towards A1, A2A or A3 receptors, which results in a variety of therapeutic potentialities of these ligands. (unige.it)
  • In this work, we present a QSAR study on these analogues as antagonists for adenosine A1 receptors. (unige.it)
  • Using the MOE software we identified a pool of descriptors that numerically describes the ligand features impacting the affinity at adenosine A1 receptors. (unige.it)
  • 4-6), containing aralkyl chains on N7 and N8 positions, were synthesized and tested as antagonists in receptor binding and in vitro functional assays to evaluate their potency for A(2A) compared with A1 adenosine receptors. (unife.it)
Class2
  • Pyrazolo[3,4-b]pyridines have been recently presented as a novel class of adenosine A1 receptor antagonists. (unige.it)
  • The obtained information is useful to understand the main structural features that strongly correlate with the A1 antagonism in this class of compounds and will be used for the rational design of more potent and selective pyrazolo[3,4-b]pyridine derivatives. (unige.it)