A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
A plant genus of the family Cycadaceae, order Cycadales, class Cycadopsida, division CYCADOPHYTA of palm-like trees. It is a source of CYCASIN, the beta-D-glucoside of methylazoxymethanol.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
Diamino acids are a type of modified amino acids containing two amino groups, which can be found in various biological molecules and play important roles in various cellular processes, such as nitrogen fixation and protein synthesis.
An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (1/587)

BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection.  (+info)

Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS. (2/587)

The objective was to determine whether the use of intermediate echo times (135 ms) in proton magnetic resonance spectroscopy (1H-MRS) detects a homogenous pattern in progressive multifocal leukoencephalopathy (PML) in HIV-1 infected people, and to confirm the results of previous studies. Six patients infected with HIV-1, with PML established by biopsy, and six healthy age and sex matched volunteers were evaluated to define their spectroscopic pattern. 1H-MRS spectra performed at 1.5 T were obtained with the STEAM sequence: TE/TM/TR, 20 ms/13.7 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (STEAM-20) and with the PRESS sequence; TE/TR, 135 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (PRESS-135). A single voxel was placed on the lesions and on the parieto-occipital white matter of controls. The peaks of N-acetylaspartate (NAA), choline (Cho), myoinositol (mI), lactate, and lipids were considered, and the results were expressed using creatine as reference. Spectra of PML lesions were characterised by significantly reduced NAA, lactate presence, and by significantly increased Cho and lipids compared with control group values. These results indicate that 1H-MRS detects a homogenous pattern in PML lesions. Recent studies, together with this, suggest that 1H-MRS may help in the diagnostic approach to patients with suspected PML lesions associated with AIDS.  (+info)

Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. (3/587)

Oxidative stress is suggested to be involved in several neurodegenerative diseases. One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide. Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen intermediates and peroxynitrite was investigated in brain tissue of AIDS patients with and without AIDS dementia complex and HIV-seronegative controls. RNA expression of IL-1beta, IL-10, inducible nitric oxide synthase, and superoxide dismutase (SOD) was found to be significantly higher in demented compared with nondemented patients. Immunohistochemical analysis showed that SOD was expressed in CD68-positive microglial cells while inducible nitric oxide synthase was detected in glial fibrillary acidic protein (GFAP)-positive astrocytes and in equal amounts in microglial cells. Approximately 70% of the HIV p24-Ag-positive macrophages did express SOD, suggesting a direct HIV-induced intracellular event. HIV-1 infection of macrophages resulted in both increased superoxide anion production and elevated SOD mRNA levels, compared with uninfected macrophages. Finally, we show that nitrotyrosine, the footprint of peroxynitrite, was found more intense and frequent in brain sections of demented patients compared with nondemented patients. These results indicate that, as a result of simultaneous production of superoxide anion and nitric oxide, peroxynitrite may contribute to the neuropathogenesis of HIV-1 infection.  (+info)

Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. (4/587)

BACKGROUND: Fifteen to thirty percent of AIDS patients develop some type of neurologic disorder during the course of their illness and the vast majority of these neurologic disorders will be HIV-associated dementia (HAD). These patients can exhibit varying degrees of severity and rates of progression of HAD. Neuropathologic variables that are associated with the rate of progression of HAD are not known. MATERIALS AND METHODS: Tissue was collected at autopsy from the Johns Hopkins University HIV Neurology Program. Seventy-one AIDS patients of this prospectively characterized population were followed until death to obtain information on dementia severity and the rate of neurological progression. Immunoblot analysis of immunological nitric oxide synthase (iNOS), HAM56, gp41, p24, gp120, and beta-tubulin was performed and the levels of iNOS, HAM56, gp41, and p24 were normalized to beta-tubulin and analyzed for significance by means of the Kruskal-Wallis test for multiple groups. RESULTS: We have identified unique groups within this spectrum and designated them slow, moderate, and rapid progressors. Slow and moderate progressors' neurological progression occurs over a course of months to years, whereas the rapid progressors' disease shows rapid increases in severity over weeks to months. In the present study we demonstrate that the severity and rate of progression of HAD correlates significantly with levels of the HIV-1 coat protein, gp41, iNOS, and HAM56, a marker of microglial/macrophage activation. CONCLUSION: The severity and rate of progression of HAD correlates with indices of immune activation as well as levels of iNOS and gp41. There appears to be a threshold effect in which high levels of gp41, iNOS, and immune activation are particularly associated with severe (Memorial Sloan-Kettering score 3 to 4) and rapidly progressive HAD.  (+info)

The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases. (5/587)

The neuropathogenesis of human immunodeficiency virus (HIV)-associated dementia has remained elusive, despite identification of HIV as the causal agent. Although a number of contributing factors have been identified, the series of events that culminate in motor and cognitive impairments after HIV infection of the central nervous system (CNS) are still not known. Rhesus monkeys infected with simian immunodeficiency virus (SIV) manifest immunosuppression and CNS disease that is pathologically [L. R. Sharer et al. (1991) J. Med. Primatol. 20, 211-217] and behaviorally [E. A. Murray et al. (1992) Science 255, 1246-1249] similar to humans. The SIV model of HIV-associated dementia (HAD) is widely recognized as a highly relevant model in which to investigate neuropathogenesis. With better understanding of neuropathogenesis comes the opportunity to interrupt progression and to design better treatments for HAD. This becomes increasingly important as patients live longer yet still harbor HIV-infected cells in the CNS. The use of the SIV model has allowed the identification of neurochemical markers of neuropathogenesis important not only for HAD, but also for other inflammatory neurological diseases.  (+info)

Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex? (6/587)

Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, abused drugs play in HADC. In this review we discuss the clinical and pathological evidence that cocaine and ethanol might exacerbate the detrimental effects of HIV infection on the brain. We also review studies of cocaine and ethanol effects on various components of the immune system both in the presence and absence of retroviral infection. Data from these studies indicate that cocaine and ethanol have profound effects on the immune system that, in many respects, are enhanced by retroviral infection. We conclude that abused drugs likely affect the course of HADC but that proof awaits an examination of their interactive effects in an appropriate in vivo system of retroviral encephalitis.  (+info)

Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings. (7/587)

BACKGROUND AND PURPOSE: Progressive multifocal leukoencephalopathy (PML) is typically occult at angiography and fails to enhance on MR images. After observing angiographic abnormalities characterized by arteriovenous shunting and pathologic parenchymal blush in patients with AIDS-related PML, often in the absence of contrast enhancement on MR images, we hypothesized that there might be distinct changes in the cerebral microvasculature that account for the reduction in vascular transit time (arteriovenous shunting) in the absence of blood-brain barrier dysfunction. METHODS: The imaging studies and neuropathologic specimens of six patients with biopsy-proved PML were reviewed retrospectively. In all patients contrast-enhanced MR imaging and CT, followed by cerebral angiography, were performed before stereotactically directed biopsy. The angiograms were evaluated for the presence of vascular displacement, pathologic parenchymal blush, arteriovenous shunting, and neovascularity. The CT and MR studies were reviewed for the presence of enhancement of the PML lesions. Biopsy specimens were examined for the presence of necrosis, perivascular inflammation, and neovascularity. RESULTS: All patients had oligodendrocytic intranuclear inclusions diagnostic of PML, together with perivascular inflammation and neovascularity to a varying extent; no other neuropathologic processes were identified. Angiographic abnormalities, characterized by a pathologic parenchymal blush and arteriovenous shunting, were identified in four of the six patients. In only one of these cases, however, was abnormal enhancement identified on cross-sectional imaging studies (MR and CT), and this patient had florid perivascular inflammatory infiltrates histologically. CONCLUSION: The pathologic parenchymal blush and arteriovenous shunting seen angiographically in some patients with PML reflect small-vessel proliferation and perivascular inflammatory changes incited by the presence of the JC virus in infected oligodendrocytes.  (+info)

Bipolar disorder in old age. (8/587)

OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential.  (+info)

AIDS Dementia Complex (ADC) is a neurological disorder that occurs in people with advanced HIV infection or AIDS. It is also known as HIV-associated dementia (HAD) or HIV encephalopathy. ADC is characterized by cognitive impairment, motor dysfunction, and behavioral changes that can significantly affect the individual's daily functioning and quality of life.

The symptoms of AIDS Dementia Complex may include:
- Difficulty with concentration and memory
- Slowness in thinking, processing information, or making decisions
- Changes in mood or personality, such as depression, irritability, or apathy
- Difficulty with coordination, balance, or speech
- Progressive weakness and wasting of muscles
- Difficulty with swallowing or speaking

The exact cause of ADC is not fully understood, but it is believed to be related to the direct effects of HIV on the brain. The virus can infect and damage nerve cells, leading to inflammation and degeneration of brain tissue. Treatment for ADC typically involves antiretroviral therapy (ART) to control HIV replication, as well as medications to manage specific symptoms. In some cases, supportive care such as physical therapy or occupational therapy may also be recommended.

I'm sorry for any confusion, but "Peptide T" is not a widely recognized or established medical term. It appears that you might be referring to "T-20," which is also known as "Enfuvirtide." Enfuvirtide is a medication used in the treatment of HIV infection. It is a synthetic peptide that mimics a portion of the gp41 protein, which is a component of the viral envelope of HIV. By binding to this protein, enfuvirtide prevents the virus from infecting cells, providing an additional line of defense against the virus in combination therapy regimens.

If you meant something else by "Peptide T," please provide more context or clarify your question so I can give you a more accurate answer.

Dementia is a broad term that describes a decline in cognitive functioning, including memory, language, problem-solving, and judgment, severe enough to interfere with daily life. It is not a specific disease but rather a group of symptoms that may be caused by various underlying diseases or conditions. Alzheimer's disease is the most common cause of dementia, accounting for 60-80% of cases. Other causes include vascular dementia, Lewy body dementia, frontotemporal dementia, and Huntington's disease.

The symptoms of dementia can vary widely depending on the cause and the specific areas of the brain that are affected. However, common early signs of dementia may include:

* Memory loss that affects daily life
* Difficulty with familiar tasks
* Problems with language or communication
* Difficulty with visual and spatial abilities
* Misplacing things and unable to retrace steps
* Decreased or poor judgment
* Withdrawal from work or social activities
* Changes in mood or behavior

Dementia is a progressive condition, meaning that symptoms will gradually worsen over time. While there is currently no cure for dementia, early diagnosis and treatment can help slow the progression of the disease and improve quality of life for those affected.

Acquired Immunodeficiency Syndrome (AIDS) is a chronic, life-threatening condition caused by the Human Immunodeficiency Virus (HIV). AIDS is the most advanced stage of HIV infection, characterized by the significant weakening of the immune system, making the person more susceptible to various opportunistic infections and cancers.

The medical definition of AIDS includes specific criteria based on CD4+ T-cell count or the presence of certain opportunistic infections and diseases. According to the Centers for Disease Control and Prevention (CDC), a person with HIV is diagnosed with AIDS when:

1. The CD4+ T-cell count falls below 200 cells per cubic millimeter of blood (mm3) - a normal range is typically between 500 and 1,600 cells/mm3.
2. They develop one or more opportunistic infections or cancers that are indicative of advanced HIV disease, regardless of their CD4+ T-cell count.

Some examples of these opportunistic infections and cancers include:

* Pneumocystis pneumonia (PCP)
* Candidiasis (thrush) affecting the esophagus, trachea, or lungs
* Cryptococcal meningitis
* Toxoplasmosis of the brain
* Cytomegalovirus disease
* Kaposi's sarcoma
* Non-Hodgkin's lymphoma
* Invasive cervical cancer

It is important to note that with appropriate antiretroviral therapy (ART), people living with HIV can maintain their CD4+ T-cell counts, suppress viral replication, and prevent the progression to AIDS. Early diagnosis and consistent treatment are crucial for managing HIV and improving life expectancy and quality of life.

HIV-1 (Human Immunodeficiency Virus type 1) is a species of the retrovirus genus that causes acquired immunodeficiency syndrome (AIDS). It is primarily transmitted through sexual contact, exposure to infected blood or blood products, and from mother to child during pregnancy, childbirth, or breastfeeding. HIV-1 infects vital cells in the human immune system, such as CD4+ T cells, macrophages, and dendritic cells, leading to a decline in their numbers and weakening of the immune response over time. This results in the individual becoming susceptible to various opportunistic infections and cancers that ultimately cause death if left untreated. HIV-1 is the most prevalent form of HIV worldwide and has been identified as the causative agent of the global AIDS pandemic.

Zidovudine is defined as an antiretroviral medication used to prevent and treat HIV/AIDS. It is a reverse transcriptase inhibitor (NRTI) that works by blocking the action of the reverse transcriptase enzyme, thereby preventing the virus from replicating in human cells.

Zidovudine is often used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) to manage HIV infection and reduce the risk of transmission. It is also used to prevent mother-to-child transmission of HIV during pregnancy, labor, delivery, and breastfeeding.

The most common side effects of zidovudine include headache, nausea, vomiting, and muscle pain. Prolonged use of zidovudine can lead to serious side effects such as anemia, neutropenia, and lactic acidosis. Therefore, regular monitoring of blood counts and liver function tests is necessary during treatment with this medication.

I'm not aware of a medical definition for the term "Cycas." It is a genus name in botany, referring to a group of plants commonly known as cycads. Cycads are ancient seed plants that have been on Earth for millions of years. They are often grown as ornamental plants due to their unique appearance.

While there may not be a direct medical definition for "Cycas," it is worth noting that some parts of the cycad plant, particularly the seeds, contain toxic compounds that can cause serious health issues in both humans and animals if ingested. These toxins can affect the nervous system, liver, and kidneys, leading to symptoms such as vomiting, seizures, and even death in severe cases.

Therefore, while "Cycas" may not have a medical definition per se, it is still important to be aware of its potential health risks.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

HIV Envelope Protein gp120 is a glycoprotein that is a major component of the outer envelope of the Human Immunodeficiency Virus (HIV). It plays a crucial role in the viral infection process. The "gp" stands for glycoprotein.

The gp120 protein is responsible for binding to CD4 receptors on the surface of human immune cells, particularly T-helper cells or CD4+ cells. This binding initiates the fusion process that allows the virus to enter and infect the cell.

After attachment, a series of conformational changes occur in the gp120 and another envelope protein, gp41, leading to the formation of a bridge between the viral and cell membranes, which ultimately results in the virus entering the host cell.

The gp120 protein is also one of the primary targets for HIV vaccine design due to its critical role in the infection process and its surface location, making it accessible to the immune system. However, its high variability and ability to evade the immune response have posed significant challenges in developing an effective HIV vaccine.

Diamino acids are a type of modified amino acids that contain two amino groups (-NH2) in their side chain. In regular amino acids, the side chain is composed of a specific arrangement of carbon, hydrogen, oxygen, and sometimes sulfur atoms. However, in diamino acids, one or both of the hydrogen atoms attached to the central carbon atom (alpha carbon) are replaced by amino groups.

There are two types of diamino acids: symmetric and asymmetric. Symmetric diamino acids have identical side chains on both sides of the alpha carbon atom, while asymmetric diamino acids have different side chains on each side.

Diamino acids play a crucial role in various biological processes, such as protein synthesis, cell signaling, and neurotransmission. They can be found naturally in some proteins or can be synthesized artificially for use in research and medical applications.

It is important to note that diamino acids are not one of the twenty standard amino acids that make up proteins. Instead, they are considered non-proteinogenic amino acids, which means they are not typically encoded by DNA and are not directly involved in protein synthesis. However, some modified forms of diamino acids can be found in certain proteins as a result of post-translational modifications.

Vascular dementia is a type of dementia that is caused by damage to the blood vessels that supply blood to the brain. This damage can result from conditions such as stroke, chronic high blood pressure, diabetes, or other diseases that affect the circulatory system. The interruption in blood flow to the brain can lead to damaged or dead brain cells, which can impair cognitive function and cause symptoms similar to those seen in other types of dementia, such as Alzheimer's disease.

The symptoms of vascular dementia can vary depending on the severity and location of the damage to the blood vessels. However, common symptoms include difficulties with memory, attention, and decision-making; problems with language and speech; changes in mood or behavior; and difficulty walking or performing other physical tasks. Vascular dementia is typically a progressive condition, meaning that the symptoms tend to worsen over time.

It's important to note that vascular dementia can coexist with other types of dementia, such as Alzheimer's disease, and this is known as mixed dementia. Proper diagnosis and management of underlying medical conditions that contribute to vascular dementia can help slow down the progression of cognitive decline and improve quality of life for individuals living with this condition.

HIV Core Protein p24 is a structural protein that forms the cone-shaped core of the human immunodeficiency virus (HIV). It is one of the earliest and most abundant viral proteins produced during the replication cycle of HIV. The p24 antigen is often used as a marker for HIV infection in diagnostic tests, as its levels in the blood tend to correlate with the amount of virus present.

The core protein p24 plays a critical role in the assembly and infectivity of the virus. It helps to package the viral RNA and enzymes into the virion, and is also involved in the fusion of the viral and host cell membranes during infection. The p24 protein is produced by cleavage of a larger precursor protein called Gag, which is encoded by the HIV genome.

In addition to its role in the viral life cycle, p24 has also been the target of HIV vaccine development efforts, as antibodies against this protein can neutralize the virus and prevent infection. However, developing an effective HIV vaccine has proven to be a significant challenge due to the virus's ability to mutate and evade the immune system.

Knox was diagnosed with Aids Dementia Complex (ADC), which made it impossible for him to live at home. In addition to memory ... ACTIONAID XV International AIDS Conference held in Bangkok. An exhibition to expose the extreme stigma attached to HIV/AIDS. ... After the launch of the Positive Lives project in 1993, a HIV/AIDS photographic collaboration between the Terrence Higgins ... IFDP (International Fund for Documentary Photography) award for photographic essay Living with Aids on Thailand. Pictures of ...
... an HLA-B serotype AIDS dementia complex (ICD-10 code) Bundesstraße 22, a German road Chery B22, a 2008 Chinese Chery Automobile ...
AIDS dementia complex, vasculitis, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In every case ... It is these changes in astrogliosis which allow the process to be complex and multifaceted, involving both a gain or loss of ... Future directions for identifying novel therapeutic strategies must carefully account for the complex array of factors and ... and the balance between these is due to a complex array of factors and molecular signaling mechanisms, which affect the ...
... science Affirming the consequent Afterburn Age regression Ageing Aggression Agoraphobia Agraphia AIDS dementia complex Akinesia ... Demand characteristics Dementia Dementia praecox Denial Dental fear Dependency need Dependent personality disorder ... Studies Multi-infarct dementia Multilevel model Multilevel models Multisensory integration Multimodal therapy Multiple-complex ... Self psychology Self serving bias Selfishness Semantic dementia Semantic dyslexia Semantic memory Semantics Senile dementia ...
HIV encephalopathy-AIDS dementia complex, pneumococcal meningitis, hypoadrenal crisis, methylmalonic acidemia, propionic ... AIDS dementia and other basal ganglia disorders: brain implants, stem cell neurorestoration, growth factors, monoaminergic ... The excessive tone can also be managed with hanging doorway baby exercisers and other aids to the upright stance that do not ...
... aids-associated nephropathy MeSH C20.673.480.070 - aids dementia complex MeSH C20.673.480.080 - aids-related complex MeSH ... aids-related MeSH C20.683.515.761.480.150.570 - lymphoma, mucosa-associated lymphoid tissue MeSH C20.683.515.761.480.150.700 - ... aids arteritis, central nervous system MeSH C20.673.480.050 - ... C20.673.480.100 - aids-related opportunistic infections MeSH ...
... dementia MeSH C10.228.140.380.070 - aids dementia complex MeSH C10.228.140.380.100 - alzheimer disease MeSH C10.228.140.380.132 ... dementia, vascular MeSH C10.228.140.300.400.203 - cadasil MeSH C10.228.140.300.400.408 - dementia, multi-infarct MeSH C10.228. ... aids arteritis, central nervous system MeSH C10.114.875.350 - lupus vasculitis, central nervous system MeSH C10.114.875.700 - ... aids arteritis, central nervous system MeSH C10.228.140.300.850.250 - lupus vasculitis, central nervous system MeSH C10.228. ...
... dementia MeSH F03.087.400.050 - aids dementia complex MeSH F03.087.400.100 - alzheimer disease MeSH F03.087.400.125 - primary ... dementia, multi-infarct MeSH F03.087.400.390 - huntington disease MeSH F03.087.400.431 - Klüver-Bucy syndrome MeSH F03.087. ... progressive aphasia MeSH F03.087.400.300 - creutzfeldt-jakob syndrome MeSH F03.087.400.350 - dementia, vascular MeSH F03.087. ...
... type 1 Ahumada-Del Castillo syndrome Aicardi-Goutières syndromes Aicardi syndrome Aichmophobia AIDS AIDS dementia complex AIDS ... deficiency of Acyl-CoA oxidase deficiency Adactylia unilateral dominant ADAM complex Adams-Nance syndrome Adams-Oliver syndrome ...
AIDS dementia complex Alzheimer's disease Amyotrophic lateral sclerosis Combined systems disease (vitamin B12 deficiency) ... Antagonists for NMDA and AMPA receptors seem to have a large benefit, with more aid the sooner it is administered after onset ... NMDA receptor activation is particularly complex, as channel opening requires not only glutamate binding but also glycine or ...
... aids dementia complex MeSH C02.782.815.616.400.080 - aids-related complex MeSH C02.782.815.616.400.100 - aids-related ... aids-associated nephropathy MeSH C02.800.801.400.070 - aids dementia complex MeSH C02.800.801.400.080 - aids-related complex ... aids arteritis, central nervous system MeSH C02.782.815.616.400.050 - aids-associated nephropathy MeSH C02.782.815.616.400.070 ... aids arteritis, central nervous system MeSH C02.800.801.400.050 - ...
... applying magnetic spectroscopy techniques to understand AIDS Dementia Complex. During this period she became interested in pain ... One key finding is that pain is complex and cognitive, and, in Tracey's words, "sensitive to various mental processes such as ...
... may refer to: ADC (gene), a human gene AIDS dementia complex, neurological disorder associated with HIV and AIDS Allyl ... Aid to Dependent Children, an American government social program from 1935 to 1960 Aide-de-camp, assistant to a senior military ...
"Peptide T and glucose metabolism in AIDS dementia complex". J. Nucl. Med. 37 (7): 1177-80. PMID 8965193. Heseltine PN, Goodkin ... A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed ... Peptide T has several positive effects related to HIV disease and Neuro-AIDS. ... promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer's disease and sues the FDA over their efforts ...
... dementia, sensory neuropathy Campbell, T. B.; Smeaton, L. M.; Kumarasamy, N.; Flanigan, T.; Klingman, K. L.; Firnhaber, C.; ... Toxoplasmic encephalitis Hepatitis B and Hepatitis C Histoplasmosis Herpes virus infections Mycobacterium avium complex disease ... The AIDS Clinical Trials Group network (ACTG) is one of the largest HIV clinical trials organizations in the world, playing a ... In 1987, the AIDS Clinical Trials Group (ACTG) was established by the National Institute of Allergy and Infectious Diseases. In ...
Finger EC (April 2016). "Frontotemporal Dementias". Continuum (Review). 22 (2 Dementia): 464-89. doi:10.1212/CON. ... Tse W, Cersosimo MG, Gracies JM, Morgello S, Olanow CW, Koller W (August 2004). "Movement disorders and AIDS: a review". ... ALS complex of Guam) Multiple system atrophy (Shy-Drager syndrome) Neuroacanthocytosis Neuronal ceroid lipofuscinosis ... These are the four motor symptoms found in Parkinson's disease (PD) - after which it is named - dementia with Lewy bodies (DLB ...
... and Alzheimer's dementia. Diagnosis in the preclinical stage is complex and focuses on asymptomatic individuals; the latter two ... Reminiscence therapy (RT) involves the discussion of past experiences individually or in group, many times with the aid of ... Gomperts SN (April 2016). "Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Review). ... Dementia: assessment, management and support for people living with dementia and their carers (Report). National Institute for ...
AIDS has been linked to some mental disorders. Research shows that infections and exposure to toxins such as HIV and ... "HIV and Dementia". www.hopkinsmedicine.org. Baltimore MD: The Johns Hopkins University, The Johns Hopkins Hospital, and Johns ... It is not likely that changes in the metabolism of the biogenic amines alone will account for the complex phenomena of normal ... No specific gene results in a complex trait disorder, but specific variations of alleles result in higher risk for a trait. The ...
1999). "Familial dementia caused by polymerization of mutant neuroserpin". Nature. 401 (6751): 376-9. doi:10.1038/43894. PMID ... doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A. PMID 10992299. S2CID 23441111. Belorgey D; Crowther DC; Mahadeva ... Barker-Carlson K; Lawrence DA; Schwartz BS (2003). "Acyl-enzyme complexes between tissue-type plasminogen activator and ... Onda M; Belorgey D; Sharp LK; Lomas DA (2005). "Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy ...
This "aid to the deaf" for fishes appears in some species such as carp and herring. Human perception of audio signal time ... Hearing loss is associated with Alzheimer's disease and dementia with a greater degree of hearing loss tied to a higher risk. ... In some instances it can also lead to auditory hallucinations or more complex difficulties in perceiving sound. Hearing can be ... However, they often rely on lip-reading even when they are using hearing aids. The most quiet sounds heard by people with ...
Complex hallucinations may progress over time if the primary loss of vision is due to damage of the early cortical areas. If ... or dementia. As a result of this, it is estimated that almost 60% of CBS patients hesitate to notify their physicians. By ... may aid in an accurate diagnosis. There is no treatment of proven effectiveness for CBS. For those experiencing CBS, knowing ... Complex visual hallucinations consist of highly detailed representations of people and objects. The most common hallucination ...
Chronic pain Cluster headache Cockayne syndrome Coffin-Lowry syndrome Coma Complex post-traumatic stress disorder Complex ... neurological manifestations Akinetopsia Alcohol related brain damage Alcoholism Alcoholic dementia Alien hand syndrome Allan- ... References 22q13 deletion syndrome Abulia Achromatopsia Addiction Acquired brain injury Agraphia Agnosia Aicardi syndrome AIDS ... disease De Morsier's syndrome Dejerine-Klumpke palsy Dejerine-Sottas disease Delayed sleep phase disorder or syndrome Dementia ...
In the Yi religion Bimoism, Zhyge Alu aids the bimo priests in curing leprosy and fighting ghosts. Jiegujienuo was a ghost that ... of China has helped the revival of the Bimoist faith through the construction of large temples and ceremonial complexes. The ... caused dizziness, slowness in action, dementia and anxiety. The ghost was blamed for ailments and exorcism rituals were ...
4,816,456}. Tacrine was the first FDA approved anti-dementia drug. Today there are five FDA approved anti-dementia drugs. ... Summers shuns test, seeks to widen his own; is Memory really aided; Fee-forresearch Furor. Wall Street Journal. Tuesday August ... Complex Antioxidant Blend improves Memory in community dwelling seniors. Journal of Alzheimer's Disease. 2010, 19:429-439. ... In 1984, it was inconceivable that a dementia patient could improve on a short or long term basis. Thus, psychometric scales ...
Also, aging and dementia are less in those that engage in complex cognitive tasks. The cognitive decline of those with epilepsy ... Social interactions, exercise, and novelty all play major roles in aiding the recovery of an injured subject. This has led to ... MRI detects localized cerebral cortex expansion after people learn complex tasks such as mirror reading (in this case in the ... The more education a person has received, the less the effects of aging, dementia, white matter hyperintensities, MRI-defined ...
Crohn's disease Dehydration Dementia Depression Ebola Fatty liver disease Fever Food poisoning Gastroparesis Hepatitis HIV/AIDS ... Appetite stimulation and suppression is a complex process involving many different parts of the brain and body by the use of ...
Bourgeois, M. S. (1993). "Effects of memory aids on the dyadic conversation of individuals with dementia". Journal of Applied ... Light, J.; Drager, K. (2007). "AAC technologies for young children with complex communication needs: State of the science and ... An AAC aid is any "device, either electronic or non-electronic, that is used to transmit or receive messages"; such aids range ... "Memory aids as an augmentative and alternative communication strategy for nursing home residents with dementia". Augmentative ...
A large variety of complex, abnormal, involuntary motor behaviors have been described following callosal lesions which may or ... 2007). "Alien hand syndrome in AIDS: Neuropsychological features and physiopathological considerations based on a case report ... ". Dementia & Neuropsychologia. 1 (4): 418-421. doi:10.1590/S1980-57642008DN10400016. PMC 5619440. PMID 29213422. Giroud, M; ... Part II: Patient behavior in complex and social situations: The 'environmental dependency syndrome'". Annals of Neurology. 19 ( ...
HIV/AIDS, Cognitive disorders, Dementia). ... Thus, it is likely that a complex interaction of several ... opportunistic infections AIDS-related lymphoma or metastasis of other AIDS-related cancers direct effects of HIV in the brain ... HIV-associated dementia (HAD) is not a true opportunistic infection; it is one of the few conditions caused directly by HIV ... Children with AIDS appear to have neurological diseases as a consequence of HIV-1 infection. In HIV-1 infected newborn and ...
... which is known as the AIDS-related complex (ARC). Late, advanced/immunodeficient stage AIDS is caused by the progressive ... People with such advanced HIV infections are also at greater risk for developing neurological symptoms (for example dementia ... AIDS is defined by either a CD4 cell count of less than 200 cells per microliter (which is indicative of severe ... HIV in pregnancy is the presence of an HIV/AIDS infection in a woman while she is pregnant. There is a risk of HIV transmission ...
AIDS), 46 suffered progressive dementia that was frequently accompanied by motor and behavioral dysfunction. Impaired memory ... The AIDS dementia complex: I. Clinical features Ann Neurol. 1986 Jun;19(6):517-24. doi: 10.1002/ana.410190602. ... The high incidence and unique clinical presentation of this AIDS dementia complex is consistent with the emerging concept that ... Of 70 autopsied patients with the acquired immune deficiency syndrome (AIDS), 46 suffered progressive dementia that was ...
Investigational Drugs with Clinical Trials for: AIDS Dementia Complex. ⮩ Send this page by email. ✉ Email this page to a ... AIDS Dementia Complex. Isoquinoline. AIDS Dementia Complex. >Drugname. >Indication. Subscribe to access the full database, or ...
The term AIDS dementia complex was introduced by Navia and colleagues in 1986. ... Staging of AIDS Dementia Complex. Price and Brew in 1988 outlined a clinical staging of AIDS dementia complex (ADC), the ... Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS. 2003 ... The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986 Jun. 19(6):517-24. [QxMD MEDLINE Link]. ...
The term AIDS dementia complex was introduced by Navia and colleagues in 1986. ... HIV-1 encephalopathy and AIDS dementia complex. CT scan of the brain of a patient with AIDS dementia complex (ADC) shows ... HIV-1 encephalopathy and AIDS dementia complex. CT scan of the brain of a patient with AIDS dementia complex (ADC) shows ... encoded search term (HIV Encephalopathy and AIDS Dementia Complex) and HIV Encephalopathy and AIDS Dementia Complex What to ...
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This unusual electroclinical presentation of the AIDS dementia complex underlines the fact that this condition presents a ... Thomas P, Borg M. Reversible myoclonic encephalopathy revealing the AIDS-dementia complex. Electroencephalogr Clin Neurophysiol ... AIDS dementia. EEG abnormalities usually precede brain atrophy on computed tomography (CT) of the brain. Generalized or ... The second developed myoclonus and dementia at 4 years of age; she was not infected with HIV, but her mother had AIDS. MRI ...
Categories: AIDS Dementia Complex Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
AIDS) dementia complex g. Toxoplasmosis h. Congestive heart failure (CHF), symptomatic at rest ... Mycobacterium avium complex (MAC) bacteremia, untreated, unresponsive to treatment, or treatment refused d. Progressive ...
Cerebrospinal Fluid; Biomarkers; AIDS Dementia Complex; Neurodegenerative Diseases; Neurocognitive Disorders; Neuroimaging. ... Alzheimers & Dementia : The Journal Of The Alzheimers Association 2022, 18: 88-102. PMID: 34032364, DOI: 10.1002/alz.12369. ... Current HIV/AIDS Reports 2016, 13: 209-217. PMID: 27188299, PMCID: PMC4977199, DOI: 10.1007/s11904-016-0319-7. ... AIDS Research And Therapy 2020, 17: 1. PMID: 31907064, PMCID: PMC6945418, DOI: 10.1186/s12981-019-0257-8. ...
AIDS dementia complex (28), or alcohol dependence (29) are also accompanied by significant brain atrophy, which may confound ... Neuroimaging of the AIDS dementia complex. AIDS. 1998;12:233-244.. OpenUrlPubMed ...
32] However, PML demonstrates more rapid progression than AIDS dementia complex (ADC). Involvement of the brainstem is more ... Like other HIV/AIDS-related opportunistic tumors and infections, the incidence of PML has decreased in the HAART era. [23, 24] ... Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity?. Neurology. 2004 Dec 28. 63 (12): ... The outcome of inflammatory PML is more variable than that of PML in end-stage AIDS. [9, 10, 11, 12] ...
Knox was diagnosed with Aids Dementia Complex (ADC), which made it impossible for him to live at home. In addition to memory ... ACTIONAID XV International AIDS Conference held in Bangkok. An exhibition to expose the extreme stigma attached to HIV/AIDS. ... After the launch of the Positive Lives project in 1993, a HIV/AIDS photographic collaboration between the Terrence Higgins ... IFDP (International Fund for Documentary Photography) award for photographic essay Living with Aids on Thailand. Pictures of ...
The metabolic pathology of the AIDS dementia complex. DA Rottenberg, JR Moeller, SC Strother, JJ Sidtis, BA Navia, V Dhawan ... Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation. NAS Farb, CL Grady, S Strother, DF ...
... or AIDS/dementia complex. ... Patients with HIV/AIDS. Prognosis in patients with HIV may be ... Long-term AIDS-related PCNSL outcomes with HD-MTX and combined antiretroviral therapy. Neurology. 2017 Aug 22. 89 (8):796-804. ... Gomez-Brouchet et al studied 35 patients (17 with and 18 without AIDS) with PCNSL for the presence of HHV-8 in tumor cells. The ... Human herpesvirus 8 DNA in CNS lymphomas from patients with and without AIDS. Neurology. 1998 Feb. 50(2):335-40. [QxMD MEDLINE ...
... and AIDS dementia complex. Arch Clin Neuropsychol (2009) 24:165-78. doi:10.1093/arclin/acp010 ... 7. Hales C, Neill S, Gearing M, Cooper D, Glass J, Lah J. Late-stage CTE pathology in a retired soccer player with dementia. ... Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) ...
7-hour CE course on AIDS education and bloodborne pathogens nurses and other healthcare providers. Online certificate! ... AIDS dementia complex (ADC), also known as HIV encephalopathy or HIV-associated neurocognitive disorders (HAND), can range from ... In older children and adolescents, the presentation is like that of AIDS dementia complex (ADC). ... HIV/AIDS INFECTION AMONG CHILDREN. Signs and symptoms of HIV/AIDS among the pediatric population include:. *Unusually frequent ...
... what is the incidence of concurrent dementia (AIDS dementia complex) in such myelopathic patients and what are the MR-revealed ... The possible cause of an AIDS-associated myelopathy becomes even more complex when one recognizes the existence of another ... AIDS-Associated Myelopathy: Clinical Severity, MR Findings, and Underlying Etiologies Message Subject (Your Name) has sent you ... AIDS-Associated Myelopathy: Clinical Severity, MR Findings, and Underlying Etiologies. Robert M. Quencer ...
AIDS dementia complex, HIV dementia, HIV encephalopathy, and major neurocognitive disorder due to HIV infection. ... 8. HIV-associated dementia (HAD). HAD is an advanced neurocognitive disorder, characterized by a significant decline in ... AIDS), may be found disabled under 14.11 if his or her impairment meets the criteria in that listing or is medically equivalent ... HIV-associated dementia, immune reconstitution inflammatory syndrome (IRIS), infections (bacterial, fungal, parasitic, or viral ...
The essential features of AIDS dementia complex include, but are not limited to, disabling cognitive impairment accompanied by ... ARD may occur with other forms of dementia (mixed dementia). The diagnosis of ARD is widely recognized but rarely applied, due ... Most presentations of alcohol dementia are somewhere along the spectrum between global dementia and Korsakoffs psychosis and ... of all dementia cases are related to alcohol consumption, making it the second leading cause of dementia.[3] ...
AIDS, AIDS dementia complex, ADC, antiretroviral therapy, ART, Stroke, transient ischemic attack, hemorrhage, ... dementia with Lewy bodies; FTD, frontotemporal dementia; HAD, HIV-associated dementia; Mild TBI, mild traumatic brain injury; ... dementia, Parkinsons disease, PD, Parkinsons disease dementia, PDD, dementia with Lewy body, DLB, progressive ... patients with dementia with Lewy body (DLB) and Parkinsons disease dementia (PDD) seem to have lower CSF NfL values than ...
AIDS dementia complex, and Parkinsons disease, as well as acute insults leading to massive brain cell death as a result of ... the more complex biological systems seem to become! ...
AIDS Dementia Complex What Are Symptoms of the Primary Forms of PPA? Is There Such a Thing as "Reversible" Dementia? What Are ... Vascular Dementia Dementia With Lewy Bodies (DLB) Parkinsons-Associated Dementia Frontotemporal Dementia (FTD) Huntingtons ... Dementia?. How Is Working With People Who Have PPA and Dementia Recognized as a Component of the SLPs Scope of Practice?. What ... With MCI and Dementia?. What Communication Challenges Are Typically Associated With MCI and Dementia? What Symptoms Are ...
AIDS Dementia Complex From NCATS Genetic and Rare Diseases Information Center File Formats Help:. How do I view different file ...
Growing cases of Alzheimers disease, stroke, Parkinsons disease, Huntingtons disease, AIDS, dementia complex, amyotrophic ... Aided by the growing R&D activities in the biopharmaceutical industry, the market is expected to witness a further growth in ... Global Cell Expansion Market to Grow at a CAGR of 15.0% During 2022-2027, Aided by the Rising Cases of Chronic Diseases ... The rising cases of cancer and the increased healthcare expenditure in the United States have been aiding the regional market ...
aids dementia complex - epidemiology - physiopathology - virology. 1. amylases - metabolism - secretion. 1. anti-hiv agents - ...
Acquired-Immune Deficiency Syndrome Dementia Complex -- See AIDS Dementia Complex A neurologic condition associated with the ... Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by ... Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by ... Acquired Immunodeficience Syndrome -- prevention & control : AIDS education and prevention (Online) 1 Acquired Immunodeficiency ...
Heres everything you need to know about dementia, its signs, symptoms, types and treatment options. ... AIDS Dementia Complex (ADC). The signs and symptoms of dementia. 10 common symptoms of dementia. There are many symptoms of ... What is early onset dementia?. Early onset dementia (also called younger onset dementia), is dementia that has been diagnosed ... What is Lewy body dementia?. Dementia with Lewy bodies (or Lewy body disease) is a form of dementia in which a build-up of ...
AIDS Dementia Complex 100% * Gray Matter 70% * HIV 47% * Magnetic Resonance Imaging 45% ... Dive into the research topics of Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. ... Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. ...
Dementia. *AIDS dementia complex. *Alzheimers disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntingtons ... dementia hebephrenica, dementia paranoides, dementia catatonica). The simplex type was added by Eugen Bleuler to the earlier ... Early observations that concur with symptoms of the dementia praecox of the form classified later as simplex began in 1838 with ... The description of simple schizophrenia is inter-changeable with describing symptoms as a form of dementia praecox known as ...
Keywords: HIV, acquired immune deficiency syndrome, AIDS dementia complex, encephalitis Click here to read the rest of this ... AIDS treatment linked to severe brain damage Bill Weintraub Bill Weintraub AIDS treatment linked to severe brain damage 4-15- ... AIDS/ANAL Inc. = millions PREVENTION/FROT = ? Best to you my warrior brothers Oscar Moreno-Vallejo Bill Weintraub Re: AIDS ... In the early days, long before antiretrovirals, there were those who accused POZ of glamorizing AIDS. But Brett, who had AIDS, ...

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