Increase in the mass of bone per unit volume.
Syndrome consisting of SYNOVITIS; ACNE CONGLOBATA; PALMOPLANTAR PUSTULOSIS; HYPEROSTOSIS; and OSTEITIS. The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome.
A disease of elderly men characterized by large osteophytes that bridge vertebrae and ossification of ligaments and tendon insertions.
Thickening of the inner table of the frontal bone, which may be associated with hypertrichosis and obesity. It most commonly affects women near menopause.
A rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.
Benign hypertrophy that projects outward from the surface of bone, often containing a cartilaginous component.
A characteristic symptom complex.
A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.
Fixation and immobility of a joint.
The study of disease in prehistoric times as revealed in bones, mummies, and archaeologic artifacts.
A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)
Inflammation of the bone.
A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)
Outgrowth of immature bony processes or bone spurs (OSTEOPHYTE) from the VERTEBRAE, reflecting the presence of degenerative disease and calcification. It commonly occurs in cervical and lumbar SPONDYLOSIS.
Air-filled spaces located within the bones around the NASAL CAVITY. They are extensions of the nasal cavity and lined by the ciliated NASAL MUCOSA. Each sinus is named for the cranial bone in which it is located, such as the ETHMOID SINUS; the FRONTAL SINUS; the MAXILLARY SINUS; and the SPHENOID SINUS.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Developmental bone diseases are a category of skeletal disorders that arise from disturbances in the normal growth and development of bones, including abnormalities in size, shape, structure, or composition, which can lead to various musculoskeletal impairments and deformities.
A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
'Spinal diseases' is a broad term referring to various medical conditions that affect the structural integrity, function, or health of the spinal column, including degenerative disorders, infections, inflammatory processes, traumatic injuries, neoplasms, and congenital abnormalities.
The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
Tumors or cancer of the PARANASAL SINUSES.
A long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.
Two extensive fibrous bands running the length of the vertebral column. The anterior longitudinal ligament (ligamentum longitudinale anterius; lacertus medius) interconnects the anterior surfaces of the vertebral bodies; the posterior longitudinal ligament (ligamentum longitudinale posterius) interconnects the posterior surfaces. The commonest clinical consideration is OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENT. (From Stedman, 25th ed)
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumors or cancer of the NOSE.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)

SAPHO syndrome of the temporomandibular joint associated with sudden deafness. (1/31)

We report a case of arthritis of the temporomandibular joint (TMJ) associated with sclerosing osteomyelitis of the mandible and temporal bone, causing deafness. The presence of a palmoplantar pustulosis established the diagnosis of SAPHO syndrome. SAPHO (an acronym referring to synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis) syndrome is defined by the association of characteristic osteoarticular and dermatologic manifestations, with diffuse sclerosing osteomyelitis of the mandible being a part of this entity. We review the literature of SAPHO syndrome with mandibular manifestations and discuss the mechanisms of inflammatory spread from the TMJ to the cochlea. To our knowledge, this is the first description of skull base involvement in a patient with SAPHO syndrome leading to sudden deafness.  (+info)

SAPHO syndrome or psoriatic arthritis? A familial case study. (2/31)

OBJECTIVE: To discuss the relationships between SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome and the group of spondylarthropathies. METHODS: Few reports of familial SAPHO have been published. We describe three children, two sisters and one brother, whose clinical and radiological presentation was in accordance with SAPHO syndrome. RESULTS: Two children developed psoriasis, and one child palmoplantar pustulosis. Both sacroiliac and sternoclavicular joints were involved in these three cases. Some features in our observations are also common to psoriatic arthritis. No association was found with HLA antigens, but a history of trauma preceding the onset of symptoms was present in all three children. CONCLUSIONS: We can consider that SAPHO is nosologically related to spondylarthropathies. Psoriatic arthritis could be the missing link between SAPHO and spondylarthropathies. It is likely that both genetic and environmental factors are involved.  (+info)

Diagnostic points and possible origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a radiographic study of 77 mandibular osteomyelitis cases. (3/31)

OBJECTIVES: To find diagnostic points and to identify the origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. METHODS: Fifty-two patients with mandibular suppurative osteomyelitis and 25 patients with mandibular osteomyelitis in SAPHO syndrome were included in the study. Radiographic patterns of the lesion, types of periosteal reaction and the presence of external bone resorption and bone enlargement were investigated in each case and compared between the two entities. RESULTS: Suppurative osteomyelitis demonstrated an osteolytic pattern and a lamellated type of periosteal reaction, whereas SAPHO syndrome revealed a mixed-pattern, solid-type periosteal reaction, external bone resorption and bone enlargement. CONCLUSIONS: Radiographic examination is suggested to be convenient and a useful diagnostic method of differentiating osteomyelitis in SAPHO syndrome from suppurative osteomyelitis. The periosteum is suspected to be the original site of osteomyelitic lesions in SAPHO syndrome.  (+info)

SAPHO syndrome treated with pamidronate: an open-label study of 10 patients. (4/31)

BACKGROUND: In recent years the SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) has been encountered more frequently. However, clinical evidence indicating superiority of a specific therapeutic modality is still absent. Pamidronate, a second-generation bisphosphonate, has a pronounced effect on bone metabolism by suppressing bone resorption. We report our clinical experience with intravenous pamidronate in SAPHO syndrome. METHODS: Between the years 1999 and 2003 we treated 10 patients with the SAPHO syndrome who did not respond to NSAIDs, oral corticosteroids, colchicine, methotrexate, sulphasalazine or infliximab. All patients were treated with 60 mg pamidronate, given intravenously within an hour. In cases of no response a subsequent dose was given within a month and if there was a partial response an additional infusion was given after 4 months. The primary endpoint was the disappearance of recurrent bouts of bone pain, osteitis or hyperostosis, or recurrent synovitis. Reduction of the frequency of attacks by 50% was regarded as a partial response. RESULTS: Seven of the patients were females and three were males. The age at diagnosis ranged from 26 to 68 yr. All patients had axial or peripheral arthritis and cutaneous involvement; three had severe acne, eight had pustulosis and two had concomitant psoriasis vulgaris. Hyperostosis of the anterior chest wall involving either sternocostal or sternoclavicular joints, as seen on technetium 99 bone scintigraphy, was detected in all patients. Complete remission was observed following therapy in six patients, three others partially responded and only one patient had no response. Two patients needed four cycles of pamidronate infusion, one patient needed three, six needed two infusions and one patient remitted following a single pamidronate infusion. In all but one patient pamidronate was effective in preventing recurrent bouts of pustulosis. CONCLUSION: Pamidronate seems to be a very effective mode of therapy for patients with the SAPHO syndrome, by promoting remission in all components of the disorder, such as bone, joint and skin involvement, and ceases the bouts that characterize this disorder.  (+info)

Pamidronate in the treatment of childhood SAPHO syndrome. (5/31)

BACKGROUND: SAPHO syndrome is increasingly recognized within the paediatric population. Conventional therapeutic approaches have often not been effective. Pamidronate is a second-generation bisphosphonate that affects bone turnover and demonstrates anti-inflammatory properties. In small case series it has given symptomatic relief to adults with this condition. OBJECTIVES: To report the clinical experience with pamidronate in childhood SAPHO syndrome. METHODS: A retrospective observational study of all children with SAPHO syndrome treated with pamidronate between 1996 and 2003 at a tertiary rheumatology centre. The standard dosing regime for pamidronate was 1 mg/kg to a maximum of 30 mg, administered daily for three consecutive days, repeated 3-monthly as required. Response to treatment was determined by clinical observation, patient subjective response and reduction in other treatments RESULTS: Seven girls were treated, with a median (range) age at diagnosis of 11 yr (9-15 yr). All patients demonstrated a beneficial clinical response, with relief of pain, increased activity and improved well-being. Subsequent courses of pamidronate were used in all patients. Other medications including corticosteroids and methotrexate could subsequently be stopped. Transient symptoms were associated with the initial course of pamidronate in some patients. No serious adverse events were reported. CONCLUSIONS: Pamidronate was associated with a marked improvement in function and well-being, and a reduction of pain and use of other medications in all patients, with no significant adverse effects. This study represents preliminary clinical data. A prospective multicentre study is necessary to assess the role and long-term safety of pamidronate in the management of childhood SAPHO syndrome  (+info)

Successful treatment of SAPHO syndrome with zoledronic acid. (6/31)

The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a chronic, relapsing, inflammatory condition with skin and osteoarticular manifestations. Its etiology remains unclear, and various treatment regimens with steroids and nonsteroidal antiinflammatory drugs frequently fail to control the disease, while exposing patients to the side effects of these drugs. Because the SAPHO syndrome manifests as a destructive inflammatory bone disease, use of bisphosphonates that possess antiosteoclastic and probably antiinflammatory properties has been suggested to be helpful. To our knowledge, this is the first reported case of successful treatment with zoledronic acid of SAPHO syndrome that was resistant to conventional treatment.  (+info)

Isolated thoracic spine lesion: is this the presentation of a SAPHO syndrome? A case report. (7/31)

A case of an isolated lesion of the thoracic spine attributed to SAPHO syndrome is presented. A 51-year-old man was referred for inflammatory pain in the thoracic spine. The general examination was normal (especially cutaneous and rheumatologic examinations). Laboratory analysis showed only a mild inflammatory reaction. Standard radiographs showed partial condensation of T8. Computed tomography showed osteolysis of the anterior corner of T8, and MRI revealed an abnormal signal of T8, with enlargement of the prevertebral soft tissue. Percutaneous and thoracoscopic biopsies showed a nonspecific inflammatory process, and cultures were sterile. Initially, several diagnoses were advanced: infectious spondylitis, malignant tumor, lymphomas, Paget disease, seronegative spondyloarthropathies and finally atypical SAPHO syndrome. Three months later, the patient experienced more pain. General examination was still normal. The radiological findings worsened, while the inflammatory blood tests were normal. A new thoracoscopic biopsy revealed a nonspecific inflammatory process. A diagnosis of SAPHO syndrome was made, despite the lack of typical lesions. Dramatically improving with anti-inflammatory therapy, the patient's condition was favorable at 3-year follow-up. This atypical presentation of an isolated lesion in the spine makes the diagnosis of a SAPHO syndrome difficult but possible. Spine surgeons must be aware of this rare entity, to avoid misdiagnosis and unnecessary repeated surgical biopsies.  (+info)

The usefulness of bone remodelling markers in predicting the efficacy of pamidronate treatment in SAPHO syndrome. (8/31)

OBJECTIVES: Pamidronate has recently been used in SAPHO syndrome due to its anti-osteoclastic effect. The aim of this study is to determine the usefulness of bone remodelling markers for determining the efficacy of pamidronate treatment. METHODS: Thirteen patients with SAPHO syndrome were treated with pamidronate. The treatment evaluation was done using a visual analogue scale (VAS) and also erythrocyte sedimentation rate, C-reactive protein, serum crosslaps (sCTX) and osteocalcin initially and after 3 months. A relevant clinical response was defined as an improvement in VAS of at least 40%. RESULTS: At 3 months, 7 of 13 patients had a good clinical response, as previously defined. Five of the seven patients maintained the good response over 6 months. Before the first perfusion 6 of the 13 patients had increased sCTX (upper 3250 pmol/l). In this small cohort we tried to analyse whether the increase in bone remodelling markers was associated with a good clinical response. In the responders group the mean levels of sCTX and osteocalcin at baseline were 6783.17 and 24.66, respectively, and in the non-responders group the levels were 2152 and 11.8, respectively. There was a significant difference in sCTX between the responders and the non-responders (P = 0.0044). CONCLUSION: Infusion of pamidronate is effective in SAPHO in some patients. Increased sCTX might be a prognostic marker for a good clinical response but results have to be confirmed in a larger cohort.  (+info)

Hyperostosis is a medical term that refers to an excessive growth or abnormal thickening of bone tissue. It can occur as a result of various conditions, such as inflammation, injury, or genetic disorders. The extra bone growth can cause pain, stiffness, and limited mobility in the affected area. In some cases, hyperostosis can also lead to deformities and other complications.

There are several types of hyperostosis, including:

1. Diffuse idiopathic skeletal hyperostosis (DISH): This is a condition that affects the spine, causing calcification and stiffening of the ligaments and bone spurs to form along the edges of the vertebrae. It is often asymptomatic but can cause pain and stiffness in some cases.
2. Flat bone hyperostosis: This type of hyperostosis affects the flat bones of the body, such as the skull, ribs, and pelvis. It can be caused by various conditions, including Paget's disease, fibrous dysplasia, and certain types of cancer.
3. Focal hyperostosis: This refers to localized areas of bone overgrowth that can occur in response to injury, infection, or inflammation. Examples include heterotopic ossification (the formation of bone in soft tissues) and Freiberg's infarction (a condition that affects the joint surface of the metatarsal bones in the foot).
4. Hyperostosis frontalis interna: This is a benign condition that causes thickening of the inner table of the frontal bone in the skull. It is more common in women and often asymptomatic but can cause headaches and other symptoms in some cases.

Treatment for hyperostosis depends on the underlying cause and severity of the condition. In some cases, no treatment may be necessary. However, if the condition causes pain or limits mobility, various treatments may be recommended, such as medication, physical therapy, or surgery.

Acquired hyperostosis syndrome is not a widely recognized medical term, and it may refer to several different conditions that involve abnormal bone growth or hardening. One possible condition that might be referred to as acquired hyperostosis syndrome is diffuse idiopathic skeletal hyperostosis (DISH).

Diffuse idiopathic skeletal hyperostosis is a non-inflammatory condition that affects the spine and other parts of the body. It is characterized by the calcification and ossification of ligaments and entheses, which are the sites where tendons or ligaments attach to bones. This process can lead to the formation of bony spurs or growths, called osteophytes, along the spine and other affected areas.

The exact cause of DISH is not known, but it is more common in older adults, males, and people with certain medical conditions such as diabetes and obesity. The symptoms of DISH can vary widely depending on the severity and location of the bone growths. Some people may experience stiffness, pain, or limited mobility in the affected areas, while others may have no symptoms at all.

It is important to note that there are many other conditions that can cause abnormal bone growth or hardening, so a proper medical evaluation is necessary to determine the underlying cause of any symptoms. If you have concerns about acquired hyperostosis syndrome or any other medical condition, you should speak with your healthcare provider for further guidance.

Diffuse Idiopathic Hyperostosis (DIH), also known as Forestier's Disease, is a non-inflammatory skeletal disorder characterized by the abnormal thickening and hardening (hyperostosis) of the bony portions of the spine and/or other parts of the skeleton. In DIH, there is an excessive formation of new bone along the edges of these bones, particularly at the sites where ligaments attach to the bones.

The term "idiopathic" indicates that the cause of this condition is currently unknown, while "diffuse" refers to its widespread involvement of multiple skeletal areas. The exact pathogenesis of DIH remains unclear; however, it has been suggested that there might be a connection with abnormal bone metabolism and/or localized inflammation.

DIH primarily affects middle-aged and older adults, with men being more commonly affected than women. Common symptoms include stiffness, pain, and limited mobility in the spine and joints. In some cases, DIH may also lead to complications such as spinal stenosis or nerve compression due to the excessive bone growth.

It is important to note that while hyperostosis can be a feature of various medical conditions, the term "Diffuse Idiopathic Skeletal Hyperostosis" specifically refers to this distinct clinical entity characterized by the widespread involvement of the skeleton and the absence of inflammation or other underlying causes.

Hyperostosis Frontalis Interna (HFI) is a medical condition characterized by an abnormal thickening or overgrowth of the inner table of the frontal bone, which is the bone that forms the forehead. This condition most commonly affects middle-aged to older women. The exact cause of HFI is not known, but it may be associated with hormonal factors, as it is more common in women who have gone through menopause.

In HFI, the overgrowth of bone can cause a raised, bumpy, or irregular appearance on the forehead, and can sometimes lead to headaches or other symptoms. However, many people with HFI do not experience any symptoms at all. The diagnosis of HFI is typically made based on imaging studies such as X-rays or CT scans, which show the characteristic thickening of the frontal bone.

While HFI is not a life-threatening condition, it can cause cosmetic concerns and may require treatment in some cases. Treatment options for HFI include medication to manage symptoms such as headaches, as well as surgical removal of the excess bone in severe cases.

Hyperostosis, sternocostoclavicular, is a medical condition characterized by the abnormal thickening and hardening of the bone tissue in the sternocostoclavicular joint and surrounding areas. The sternocostoclavicular joint is where the clavicle (collarbone) meets the sternum (breastbone) and manubrium, and costae (ribs). This condition can result in pain, stiffness, and limited range of motion in the affected area. The exact cause of hyperostosis, sternocostoclavicular, is not fully understood, but it may be associated with trauma, inflammation, or genetic factors. In some cases, this condition may be asymptomatic and only discovered during imaging studies performed for other reasons. Treatment options typically include pain management, physical therapy, and in some cases, surgery to remove the excess bone growth.

Exostoses are benign (noncancerous) bone growths that develop on the surface of a bone, usually in response to repeated stress or friction. They are often small and smooth, but can become larger and more irregular over time. In some cases, they may cause pain or discomfort, especially if they continue to grow and put pressure on nearby nerves, muscles, or other bones.

Exostoses can occur in various parts of the body, but they are most commonly found in the long bones of the arms and legs, as well as in the small bones of the feet. They may also develop in response to chronic irritation or injury, such as from jogging or playing sports that involve a lot of running or jumping.

In some cases, exostoses may be surgically removed if they cause persistent pain or other symptoms. However, in many cases, they do not require treatment and can be left alone. If you are concerned about any bone growths or other unusual symptoms, it is always best to consult with a healthcare professional for an accurate diagnosis and treatment plan.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Melorheostosis is a very rare, progressive bone disorder characterized by the thickening and hardening of the bones' outer covering (periosteum). The name "melorheostosis" means "melting bones," which describes the appearance of the long bones on X-rays. It resembles dripping candle wax flowing down the shafts of the bones.

The condition typically affects one side of the body, often involving the legs and arms, but can also affect the skull, spine, and ribs. The symptoms can vary widely, depending on the location and extent of bone involvement. They may include bone pain, deformities, limited mobility, joint stiffness, and skin changes over the affected bones.

The exact cause of melorheostosis is unknown, but it is not a hereditary condition. It is thought to be related to abnormal blood vessel formation during fetal development, leading to improper bone growth and development. There is no known cure for melorheostosis, but various treatments can help manage symptoms and improve quality of life. These may include pain management, physical therapy, surgery, and other supportive measures.

Ankylosis is a medical term that refers to the abnormal joining or fusion of bones, typically in a joint. This can occur as a result of various conditions such as injury, infection, or inflammatory diseases like rheumatoid arthritis. The fusion of bones can restrict movement and cause stiffness in the affected joint. In some cases, ankylosis can lead to deformity and disability if not treated promptly and effectively.

There are different types of ankylosis depending on the location and extent of bone fusion. For instance, when it affects the spine, it is called "ankylosing spondylitis," which is a chronic inflammatory disease that can cause stiffness and pain in the joints between the vertebrae.

Treatment for ankylosis depends on the underlying cause and severity of the condition. In some cases, physical therapy or surgery may be necessary to restore mobility and function to the affected joint.

Paleopathology is the study of ancient diseases and injuries as recorded in bones, mummies, and other archaeological remains. It is an interdisciplinary field that combines knowledge from pathology, epidemiology, anthropology, and archaeology to understand the health and disease patterns of past populations. The findings of paleopathology can provide valuable insights into the evolution of diseases, the effectiveness of ancient medical practices, and the impact of environmental and social factors on human health over time. Examples of conditions that may be studied in paleopathology include infectious diseases (such as tuberculosis or leprosy), nutritional deficiencies, trauma, cancer, and genetic disorders.

Inverted papilloma is a specific type of benign (non-cancerous) growth that occurs in the mucosal lining of the nasal cavity or paranasal sinuses. It is also known as schneiderian papilloma or cylindrical cell papilloma.

This condition is characterized by the growth of finger-like projections (papillae) that invert or grow inward into the underlying tissue, hence the name "inverted." The lesions are usually composed of an outer layer of stratified squamous epithelium and an inner core of connective tissue.

Inverted papillomas can cause symptoms such as nasal congestion, nosebleeds, sinus pressure, and difficulty breathing through the nose. In some cases, they may also lead to more serious complications, including recurrence after removal and a small risk of malignant transformation into squamous cell carcinoma.

It is important to note that while inverted papillomas are benign, they can still cause significant problems due to their location and tendency to recur. Therefore, they typically require surgical removal and close follow-up with an otolaryngologist (ear, nose, and throat specialist).

Osteitis is a medical term that refers to the inflammation of bone tissue. It can occur as a result of various conditions, such as infection (osteomyelitis), trauma, or autoimmune disorders. The symptoms of osteitis may include pain, swelling, warmth, and redness in the affected area, as well as fever and general malaise. Treatment typically involves addressing the underlying cause of the inflammation, which may involve antibiotics for infection or anti-inflammatory medications for other causes. In some cases, surgery may be necessary to remove infected or damaged bone tissue.

Congenital cortical hyperostosis is a rare, inherited bone disorder that is characterized by abnormal thickening of the outer layer of bones (cortical hyperostosis). This condition primarily affects the skull and long bones of the arms and legs. The exact cause of congenital cortical hyperostosis is not fully understood, but it is believed to be related to mutations in certain genes that regulate bone growth and development.

The symptoms of congenital cortical hyperostosis can vary widely from person to person, depending on the severity and location of the bone abnormalities. Some common features of this condition include:

* A thickened skull, which may cause a prominent forehead or a misshapen head
* Abnormally thick and dense long bones in the arms and legs, which can make them heavy and difficult to move
* Delayed growth and development
* Increased risk of fractures
* Pain and stiffness in the affected bones

Congenital cortical hyperostosis is typically diagnosed based on a combination of clinical symptoms, imaging studies (such as X-rays or CT scans), and genetic testing. There is no cure for this condition, but treatment may involve pain management, physical therapy, and surgery to correct any bone deformities. In some cases, the symptoms of congenital cortical hyperostosis may improve over time, but in others, they may persist throughout life.

Spinal osteophytosis, also known as spinal osteophyte formation or bone spurs on the spine, refers to the abnormal growth of bony projections along the vertebral column's margins. These bony outgrowths develop due to degenerative changes, inflammation, or injury in the joints between the vertebrae (facet joints) and can cause stiffness, pain, and reduced mobility. In some cases, spinal osteophytosis may lead to complications such as spinal stenosis or nerve compression.

Paranasal sinuses are air-filled cavities in the skull that surround the nasal cavity. There are four pairs of paranasal sinuses, including the maxillary, frontal, ethmoid, and sphenoid sinuses. These sinuses help to warm, humidify, and filter the air we breathe. They also contribute to our voice resonance and provide a slight cushioning effect for the skull. The openings of the paranasal sinuses lead directly into the nasal cavity, allowing mucus produced in the sinuses to drain into the nose. Infections or inflammation of the paranasal sinuses can result in conditions such as sinusitis.

The skull is the bony structure that encloses and protects the brain, the eyes, and the ears. It is composed of two main parts: the cranium, which contains the brain, and the facial bones. The cranium is made up of several fused flat bones, while the facial bones include the upper jaw (maxilla), lower jaw (mandible), cheekbones, nose bones, and eye sockets (orbits).

The skull also provides attachment points for various muscles that control chewing, moving the head, and facial expressions. Additionally, it contains openings for blood vessels, nerves, and the spinal cord to pass through. The skull's primary function is to protect the delicate and vital structures within it from injury and trauma.

The cervical vertebrae are the seven vertebrae that make up the upper part of the spine, also known as the neck region. They are labeled C1 to C7, with C1 being closest to the skull and C7 connecting to the thoracic vertebrae in the chest region. The cervical vertebrae have unique structures to allow for a wide range of motion in the neck while also protecting the spinal cord and providing attachment points for muscles and ligaments.

Developmental bone diseases are a group of medical conditions that affect the growth and development of bones. These diseases are present at birth or develop during childhood and adolescence, when bones are growing rapidly. They can result from genetic mutations, hormonal imbalances, or environmental factors such as poor nutrition.

Some examples of developmental bone diseases include:

1. Osteogenesis imperfecta (OI): Also known as brittle bone disease, OI is a genetic disorder that affects the body's production of collagen, a protein necessary for healthy bones. People with OI have fragile bones that break easily and may also experience other symptoms such as blue sclerae (whites of the eyes), hearing loss, and joint laxity.
2. Achondroplasia: This is the most common form of dwarfism, caused by a genetic mutation that affects bone growth. People with achondroplasia have short limbs and a large head relative to their body size.
3. Rickets: A condition caused by vitamin D deficiency or an inability to absorb or use vitamin D properly. This leads to weak, soft bones that can bow or bend easily, particularly in children.
4. Fibrous dysplasia: A rare bone disorder where normal bone is replaced with fibrous tissue, leading to weakened bones and deformities.
5. Scoliosis: An abnormal curvature of the spine that can develop during childhood or adolescence. While not strictly a developmental bone disease, scoliosis can be caused by various underlying conditions such as cerebral palsy, muscular dystrophy, or spina bifida.

Treatment for developmental bone diseases varies depending on the specific condition and its severity. Treatment may include medication, physical therapy, bracing, or surgery to correct deformities and improve function. Regular follow-up with a healthcare provider is essential to monitor growth, manage symptoms, and prevent complications.

A meningioma is a type of slow-growing tumor that forms on the membranes (meninges) surrounding the brain and spinal cord. It's usually benign, meaning it doesn't spread to other parts of the body, but it can still cause serious problems if it grows and presses on nearby tissues.

Meningiomas most commonly occur in adults, and are more common in women than men. They can cause various symptoms depending on their location and size, including headaches, seizures, vision or hearing problems, memory loss, and changes in personality or behavior. In some cases, they may not cause any symptoms at all and are discovered only during imaging tests for other conditions.

Treatment options for meningiomas include monitoring with regular imaging scans, surgery to remove the tumor, and radiation therapy to shrink or kill the tumor cells. The best treatment approach depends on factors such as the size and location of the tumor, the patient's age and overall health, and their personal preferences.

Spinal diseases refer to a range of medical conditions that affect the spinal column, which is made up of vertebrae (bones), intervertebral discs, facet joints, nerves, ligaments, and muscles. These diseases can cause pain, discomfort, stiffness, numbness, weakness, or even paralysis, depending on the severity and location of the condition. Here are some examples of spinal diseases:

1. Degenerative disc disease: This is a condition where the intervertebral discs lose their elasticity and height, leading to stiffness, pain, and decreased mobility.
2. Herniated disc: This occurs when the inner material of the intervertebral disc bulges or herniates out through a tear in the outer layer, causing pressure on the spinal nerves and resulting in pain, numbness, tingling, or weakness in the affected area.
3. Spinal stenosis: This is a narrowing of the spinal canal or the neural foramen (the openings where the spinal nerves exit the spinal column), which can cause pressure on the spinal cord or nerves and result in pain, numbness, tingling, or weakness.
4. Scoliosis: This is a curvature of the spine that can occur in children or adults, leading to an abnormal posture, back pain, and decreased lung function.
5. Osteoarthritis: This is a degenerative joint disease that affects the facet joints in the spine, causing pain, stiffness, and decreased mobility.
6. Ankylosing spondylitis: This is a chronic inflammatory disease that affects the spine and sacroiliac joints, leading to pain, stiffness, and fusion of the vertebrae.
7. Spinal tumors: These are abnormal growths that can occur in the spinal column, which can be benign or malignant, causing pain, neurological symptoms, or even paralysis.
8. Infections: Bacterial or viral infections can affect the spine, leading to pain, fever, and other systemic symptoms.
9. Trauma: Fractures, dislocations, or sprains of the spine can occur due to accidents, falls, or sports injuries, causing pain, neurological deficits, or even paralysis.

The fibula is a slender bone located in the lower leg of humans and other vertebrates. It runs parallel to the larger and more robust tibia, and together they are known as the bones of the leg or the anterior tibial segment. The fibula is the lateral bone in the leg, positioned on the outside of the tibia.

In humans, the fibula extends from the knee joint proximally to the ankle joint distally. Its proximal end, called the head of the fibula, articulates with the lateral condyle of the tibia and forms part of the inferior aspect of the knee joint. The narrowed portion below the head is known as the neck of the fibula.

The shaft of the fibula, also called the body of the fibula, is a long, thin structure that descends from the neck and serves primarily for muscle attachment rather than weight-bearing functions. The distal end of the fibula widens to form the lateral malleolus, which is an important bony landmark in the ankle region. The lateral malleolus articulates with the talus bone of the foot and forms part of the ankle joint.

The primary functions of the fibula include providing attachment sites for muscles that act on the lower leg, ankle, and foot, as well as contributing to the stability of the ankle joint through its articulation with the talus bone. Fractures of the fibula can occur due to various injuries, such as twisting or rotational forces applied to the ankle or direct trauma to the lateral aspect of the lower leg.

Paranasal sinus neoplasms refer to abnormal growths or tumors that develop within the paranasal sinuses, which are air-filled cavities located inside the skull near the nasal cavity. These tumors can be benign (noncancerous) or malignant (cancerous), and they can arise from various types of tissue within the sinuses, such as the lining of the sinuses (mucosa), bone, or other soft tissues.

Paranasal sinus neoplasms can cause a variety of symptoms, including nasal congestion, nosebleeds, facial pain or numbness, and visual disturbances. The diagnosis of these tumors typically involves a combination of imaging studies (such as CT or MRI scans) and biopsy to determine the type and extent of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches, depending on the specific type and stage of the neoplasm.

The sternum, also known as the breastbone, is a long, flat bone located in the central part of the chest. It serves as the attachment point for several muscles and tendons, including those involved in breathing. The sternum has three main parts: the manubrium at the top, the body in the middle, and the xiphoid process at the bottom. The upper seven pairs of ribs connect to the sternum via costal cartilages.

Longitudinal ligaments, in the context of anatomy, refer to the fibrous bands that run lengthwise along the spine. They are named as such because they extend in the same direction as the long axis of the body. The main function of these ligaments is to provide stability and limit excessive movement in the spinal column.

There are three layers of longitudinal ligaments in the spine:

1. Anterior Longitudinal Ligament (ALL): This ligament runs down the front of the vertebral bodies, attached to their anterior aspects. It helps to prevent hyperextension of the spine.
2. Posterior Longitudinal Ligament (PLL): The PLL is located on the posterior side of the vertebral bodies and extends from the axis (C2) to the sacrum. Its primary function is to limit hyperflexion of the spine.
3. Ligamentum Flavum: Although not strictly a 'longitudinal' ligament, it is often grouped with them due to its longitudinal orientation. The ligamentum flavum is a pair of elastic bands that connect adjacent laminae (posterior bony parts) of the vertebral arch in the spine. Its main function is to maintain tension and stability while allowing slight movement between the vertebrae.

These longitudinal ligaments play an essential role in maintaining spinal alignment, protecting the spinal cord, and facilitating controlled movements within the spine.

Meningeal neoplasms, also known as malignant meningitis or leptomeningeal carcinomatosis, refer to cancerous tumors that originate in the meninges, which are the membranes covering the brain and spinal cord. These tumors can arise primarily from the meningeal cells themselves, although they more commonly result from the spread (metastasis) of cancer cells from other parts of the body, such as breast, lung, or melanoma.

Meningeal neoplasms can cause a variety of symptoms, including headaches, nausea and vomiting, mental status changes, seizures, and focal neurological deficits. Diagnosis typically involves imaging studies (such as MRI) and analysis of cerebrospinal fluid obtained through a spinal tap. Treatment options may include radiation therapy, chemotherapy, or surgery, depending on the type and extent of the tumor. The prognosis for patients with meningeal neoplasms is generally poor, with a median survival time of several months to a year.

Skull base neoplasms refer to abnormal growths or tumors located in the skull base, which is the region where the skull meets the spine and where the brain connects with the blood vessels and nerves that supply the head and neck. These neoplasms can be benign (non-cancerous) or malignant (cancerous), and they can arise from various types of cells in this area, including bone, nerve, glandular, and vascular tissue.

Skull base neoplasms can cause a range of symptoms depending on their size, location, and growth rate. Some common symptoms include headaches, vision changes, hearing loss, facial numbness or weakness, difficulty swallowing, and balance problems. Treatment options for skull base neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The specific treatment plan will depend on the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history.

X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.

The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.

CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.

In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.

CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.

In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.

Nose neoplasms refer to abnormal growths or tumors in the nasal cavity or paranasal sinuses. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow-growing and do not spread to other parts of the body, while malignant neoplasms can invade surrounding tissues and have the potential to metastasize.

Nose neoplasms can cause various symptoms such as nasal congestion, nosebleeds, difficulty breathing through the nose, loss of smell, facial pain or numbness, and visual changes if they affect the eye. The diagnosis of nose neoplasms usually involves a combination of physical examination, imaging studies (such as CT or MRI scans), and biopsy to determine the type and extent of the growth. Treatment options depend on the type, size, location, and stage of the neoplasm and may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

"Bone" is the hard, dense connective tissue that makes up the skeleton of vertebrate animals. It provides support and protection for the body's internal organs, and serves as a attachment site for muscles, tendons, and ligaments. Bone is composed of cells called osteoblasts and osteoclasts, which are responsible for bone formation and resorption, respectively, and an extracellular matrix made up of collagen fibers and mineral crystals.

Bones can be classified into two main types: compact bone and spongy bone. Compact bone is dense and hard, and makes up the outer layer of all bones and the shafts of long bones. Spongy bone is less dense and contains large spaces, and makes up the ends of long bones and the interior of flat and irregular bones.

The human body has 206 bones in total. They can be further classified into five categories based on their shape: long bones, short bones, flat bones, irregular bones, and sesamoid bones.

Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is characterized by intellectual and developmental disabilities, distinctive facial features, and sometimes physical growth delays and health problems. The condition affects approximately one in every 700 babies born in the United States.

Individuals with Down syndrome have varying degrees of cognitive impairment, ranging from mild to moderate or severe. They may also have delayed development, including late walking and talking, and may require additional support and education services throughout their lives.

People with Down syndrome are at increased risk for certain health conditions, such as congenital heart defects, respiratory infections, hearing loss, vision problems, gastrointestinal issues, and thyroid disorders. However, many individuals with Down syndrome live healthy and fulfilling lives with appropriate medical care and support.

The condition is named after John Langdon Down, an English physician who first described the syndrome in 1866.

... acquired hyperostosis syndrome MeSH C05.116.099.708.857 - short rib-polydactyly syndrome MeSH C05.116.099.708.914 - ... Klippel-Feil syndrome MeSH C05.116.099.370.652 - orofaciodigital syndromes MeSH C05.116.099.370.797 - Rubinstein-Taybi syndrome ... hyperostosis frontalis interna MeSH C05.116.099.708.582 - Langer-Giedion syndrome MeSH C05.116.099.708.670 - osteochondroma ... Hajdu-Cheney syndrome MeSH C05.116.099.105 - basal-cell nevus syndrome MeSH C05.116.099.343 - dwarfism MeSH C05.116.099.343.110 ...
Rarer acquired causes include tumors (especially pancoast tumor), hyperostosis, and osteomyelitis Adson's sign and the ... Pectoralis minor syndrome May-Thurner syndrome - a similar compressive pathology involving the left common iliac vein Backpack ... Cervical rib syndrome (compression on brachial plexus and/or subclavian artery caused by bone growth). Costoclavicular syndrome ... 100 Operations for Pectoralis Minor Syndrome Alone or Accompanied by Neurogenic Thoracic Outlet Syndrome". Annals of Vascular ...
738 Other acquired deformity 738.0 Acquired deformity of nose 738.1 Other acquired deformity of head 738.2 Acquired deformity ... 710 Diffuse diseases of connective tissue 710.0 Systemic lupus erythematosus 710.2 Sjögren's syndrome 710.3 Dermatomyositis ... myelopathy 721.5 Kissing spine 721.6 Ankylosing vertebral hyperostosis 721.7 Traumatic spondylopathy 722 Intervertebral disc ... acquired) 736.89 Other acquired deformity of other parts of limb Winged scapula 736.9 Acquired deformity, limb, unspec. 737 ...
... hyperostosis, osteitis) syndrome, sarcoidosis and sciatica. It is also suspected a main bacterial source of neuroinflammation ... The antibiotic families that C. acnes are most likely to acquire resistance to are the macrolides (e.g., erythromycin and ...
Acquired generalized lipodystrophy (Lawrence syndrome, Lawrence-Seip syndrome) Adiposis dolorosa (Dercum's disease) Alpha-1 ... Rosacea conglobata Synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome (SAPHO syndrome) Steroid rosacea Tar acne ... Turner syndrome Ulnar-mammary syndrome Van Der Woude syndrome Von Hippel-Lindau syndrome Watson syndrome Werner syndrome (adult ... Freeman-Sheldon syndrome, Windmill-Vane-Hand syndrome) Wilson-Turner syndrome Wolf-Hirschhorn syndrome (4p- syndrome) X-linked ...
Acquired agranulocytosis Acquired central hypoventilation syndrome Acquired hypoprothrombinemia Acquired ichthyosis Acquired ... Ankyloglossia heterochromia clasped thumbs Ankylosing spondylarthritis Ankylosing spondylitis Ankylosing vertebral hyperostosis ... Pande syndrome Aarskog syndrome Aase-Smith syndrome Aase syndrome Abasia ABCD syndrome Abdallat-Davis-Farrage syndrome ... syndrome Akesson syndrome Aksu-Stckhausen syndrome Al Awadi Teebi Farag syndrome Al Frayh Facharzt Haque syndrome Al Gazali Al ...
... chronic spasmodic Dysplasia epiphysealis hemimelica Dysplasia Dysplastic cortical hyperostosis Dysplastic nevus syndrome ... congenital type 3 Dysexecutive syndrome Dysferlinopathy Dysfibrinogenemia, familial Dysfibrinogenemia, acquired Dysgerminoma ... syndrome Daneman-Davy-Mancer syndrome Darier's disease Davenport-Donlan syndrome DAVID syndrome Davis-Lafer syndrome De Barsy ... Salih-Patel syndrome Dinno-Shearer-Weisskopf syndrome Diomedi-Bernardi-Placidi syndrome Dionisi-Vici-Sabetta-Gambarara syndrome ...
... tethered spinal cord syndrome, and connective tissue disorders such as Ehlers-Danlos syndrome and Marfan syndrome. Chiari ... O'Shaughnessy BA, Bendok BR, Parkinson RJ, Shaibani A, Walker MT, Shakir E, Batjer HH (January 2006). "Acquired Chiari ... Congenital causes include hydrocephalus, craniosynostosis (especially of the lambdoid suture), hyperostosis (such as ... Chiari malformation or Arnold-Chiari malformation should not be confused with Budd-Chiari syndrome, a hepatic condition also ...
Cohen and Tibbles said Merrick showed the following signs of Proteus syndrome: "macrocephaly; hyperostosis of the large skull; ... there is evidence to suggest that Merrick acquired that particular costume a year later, while travelling with Sam Roper's Fair ... In fact, Proteus syndrome affects tissue other than nerves, and is a sporadic disorder rather than a genetically transmitted ... The exact cause of Merrick's deformities is unclear, but in 1986 it was conjectured that he had Proteus syndrome. In a 2003 ...
... homocitrullinuria syndrome Hyperostosid corticalis deformans juvenilis Hyperostosis cortical infantile Hyperostosis corticalis ... acquired Hypertrichosis retinopathy dysmorphism Hypertrichosis, anterior cervical Hypertrichotic osteochondrodysplasia ... Mcdonald syndrome Hunter-Jurenka-Thompson syndrome Hunter-Macpherson syndrome Hunter-Mcalpine syndrome Hunter-Mcdonald syndrome ... child Heavy metal poisoning HEC syndrome Hecht-Scott syndrome Heckenlively syndrome Heide syndrome Heliophobia HELLP syndrome ...
Towards the end of the 14th century, the abbey acquired a "giant" statue of Saint Christopher. Three wills from members of the ... The only major congenital abnormality found consisted of bony changes resulting from a possible case of Down's syndrome. ... Other diseases specific to bones and joints were osteoarthritis, diffuse idiopathic skeletal hyperostosis (DISH), and possible ... and three crania had features of hyperostosis frontalis interna, a metabolic condition affecting post-menopausal women. ...
MAT1A Hyperornithinemia-hyperammonemia-homocitrullinemia syndrome; 238970; SLC25A15 Hyperostosis, endosteal; 144750; LRP5 ... acquired; 608709; LMNB2 Lipoid adrenal hyperplasia; 201710; STAR Lipoid congenital adrenal hyperplasia; 201710; CYP11A Lipoid ... AKAP9 Long QT syndrome-3; 603830; SCN5A Long QT syndrome-4; 600919; ANK2 Long QT syndrome-7; 170390; KCNJ2 Long QT syndrome-9; ... TGFBR2 Long QT syndrome 12; 612955; SNT1 Long QT syndrome 13; 613485; KCNJ5 Long QT syndrome-1; 192500; KCNQ1 Long QT syndrome- ...
The acquired hyperostosis syndrome. Synthesis of 13 personal observations of sternocostoclavicular hyperostosis and 300 cases ... Dihlmann W (1993) Acquired hyperostosis syndrome (so-called pustular arthro-osteitis). Review of the literature including 73 ... Beretta-Piccoli BC et al (2000) Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ... Olivieri I, Padula A, Ciancio G et al (2002) Successful treatment of SAPHO syndrome with infliximab: report of two cases. Ann ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
SEROTONIN SYNDROME. SINDROME DE LA SEROTONINA. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE ...
ACQUIRED HYPEROSTOSIS SYNDROME. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. SINDROME DE LA SEROTONINA. SEROTONIN SYNDROME. SÍNDROME DA ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
SEROTONIN SYNDROME. SINDROME DE LA SEROTONINA. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
ACQUIRED HYPEROSTOSIS SYNDROME. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. SINDROME DE LA SEROTONINA. SEROTONIN SYNDROME. SÍNDROME DA ...
SEROTONIN SYNDROME. SINDROME DE LA SEROTONINA. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE ...
ACQUIRED HYPEROSTOSIS SYNDROME. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. SINDROME DE LA SEROTONINA. SEROTONIN SYNDROME. SÍNDROME DA ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
ACQUIRED HYPEROSTOSIS SYNDROME. SINDROME DE HIPEROSTOSIS ADQUIRIDO. SÍNDROME DE HIPEROSTOSE ADQUIRIDA. ACROSOME REACTION. ... HEPATOPULMONARY SYNDROME. SINDROME HEPATOPULMONAR. SÍNDROME HEPATOPULMONAR. HETERODUPLEX ANALYSIS. ANALISIS HETERODUPLEX. ...
Acquired Hyperostosis Syndrome 1 0 Anthracosis 1 0 Arthritis 1 0 Clostridium Infections 1 0 ...
keywords = "Acquired Hyperostosis Syndrome, Adult, Chromatography, High Pressure Liquid, Female, Humans, Middle Aged, Proteome ... Acquired Hyperostosis Syndrome, Adult, Chromatography, High Pressure Liquid, Female, Humans, Middle Aged, Proteome, Proteomics ... The salivary proteome profile in patients affected by SAPHO syndrome characterized by a top-down RP-HPLC-ESI-MS platform. In: ... The salivary proteome profile in patients affected by SAPHO syndrome characterized by a top-down RP-HPLC-ESI-MS platform. ...
... acquired hyperostosis syndrome MeSH C05.116.099.708.857 - short rib-polydactyly syndrome MeSH C05.116.099.708.914 - ... Klippel-Feil syndrome MeSH C05.116.099.370.652 - orofaciodigital syndromes MeSH C05.116.099.370.797 - Rubinstein-Taybi syndrome ... hyperostosis frontalis interna MeSH C05.116.099.708.582 - Langer-Giedion syndrome MeSH C05.116.099.708.670 - osteochondroma ... Hajdu-Cheney syndrome MeSH C05.116.099.105 - basal-cell nevus syndrome MeSH C05.116.099.343 - dwarfism MeSH C05.116.099.343.110 ...
Acquired Hyperostosis Syndrome [C05.116.099.708.025] * Camurati-Engelmann Syndrome [C05.116.099.708.180] ...
SAPHO Syndrome use Acquired Hyperostosis Syndrome SAPHO Syndromes use Acquired Hyperostosis Syndrome ... Saldino Noonan Syndrome use Short Rib-Polydactyly Syndrome Saldino-Noonan Syndrome use Short Rib-Polydactyly Syndrome ...
Rubinstein-Taybi Syndrome. *Silver-Russell Syndrome. *Osteochondrodysplasias. *Achondroplasia. *Acquired Hyperostosis Syndrome ... Autosomal dominant syndrome in which there is delayed closing of the CRANIAL FONTANELLES; complete or partial absence of the ...
Acquired Hyperostosis Syndrome. *Camurati-Engelmann Syndrome. *Chondrodysplasia Punctata. *Cleidocranial Dysplasia. *Ellis-Van ... A syndrome inherited as an autosomal recessive trait and incompatible with life. The main features are narrow thorax, short ... "Short Rib-Polydactyly Syndrome" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... This graph shows the total number of publications written about "Short Rib-Polydactyly Syndrome" by people in this website by ...
Acquired Hyperostosis Syndrome. *Camurati-Engelmann Syndrome. *Chondrodysplasia Punctata. *Cleidocranial Dysplasia. *Ellis-Van ...
4. Patients with SAPHO (Synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. 5. Immediate life-threatening flare of GPP ... congenital or acquired immunodeficiency (e.g. HIV), past organ or stem cell transplantation), as assessed by the investigator. ... distress syndrome, or acute renal failure. 6. Severe, progressive, or uncontrolled hepatic disease, defined as >3-fold ULN ...
Aplasia Cutis Congenita AD,AR 99.12 115 of 115 KAT6B Genitopatellar Syndrome, Ohdo Syndrome, Blepharophimosis-Intellectual ... Onset is usually during childhood or adolescence (hereditary) or during later adulthood (acquired), often in patients with a ... bone involvement was reported by Engelmann in 1929.(6-9) As the name suggests, there is progressive hyperostosis and ... Aplasia Cutis Congenita AD,AR 99.12 115 of 115 KAT6B Genitopatellar Syndrome, Ohdo Syndrome, Blepharophimosis-Intellectual ...
Fragile X syndrome Fragile X Syndrome Fragile X syndrome is a genetic abnormality on the X chromosome that leads to ... These conditions may be the result of genetic disorders or disorders the child acquired before or after birth (3 General ... cranial hyperostosis, or other conditions. ... Treatment is supportive... read more , Sotos syndrome, and ... and an overgrowth syndrome (eg, growth hormone excess Gigantism and Acromegaly Gigantism and acromegaly are syndromes of ...
Macrocephaly can be the first manifestation of various congenital and acquired neurologic conditions or may be just a familial ... Neurocutaneous disroders - Tuberous sclerosis, Sturge-weber syndrome, neurofibromatosis, Gorlin syndrome. *Autism spectrum ... Macrocephaly can be the first manifestation of various congenital and acquired neurologic conditions or may be just a familial ... Hyperostosis cranii - associated with disorders such as osteogenesis imperfecta, achondroplasia, and osteopetrosis ...
Klippel-Feil syndrome Page: Kyphosis (Pediatric) Page: Legg-Calve-Perthes syndrome Page: Leg length discrepancy (Pediatric) ... Page: Accessory navicular Page: Achondroplasia Page: Acquired flatfoot (Pediatric) Page: Adolescent bunion Page: Adolescent ... Infantile cortical hyperostosis Page: Infantile idiopathic scoliosis Page: Intramembranous bone formation Page: Juvenile ... Downs syndrome Page: Duchenne muscular dystrophy Page: Ehlers-Danlos syndrome Page: Enchondral ossification Page: Ewing ...
Polyarteritis nodosa - Churg-Strauss syndrome - Kawasaki disease - Hypersensitivity vasculitis - Goodpastures syndrome - ... acquired deformities of fingers and toes (Boutonniere deformity, Bunion, Hallux rigidus, Hallux varus, Hammer toe) - other ... Hyperostosis - Osteosclerosis. Osteomyelitis - Avascular necrosis - Pagets disease of bone - Algoneurodystrophy - Osteolysis ... Infantile cortical hyperostosis. Chondropathies. Juvenile osteochondrosis (Legg-Calvé-Perthes syndrome, Osgood-Schlatter ...
722.81 POSTLAMINECTOMY SYNDROME OF CERVICAL REGION. *722.82 POSTLAMINECTOMY SYNDROME OF THORACIC REGION ... 721.6 ANKYLOSING VERTEBRAL HYPEROSTOSIS. *721.90 SPONDYLOSIS OF UNSPECIFIED SITE WITHOUT MYELOPATHY. *721.91 SPONDYLOSIS OF ... 738.4 ACQUIRED SPONDYLOLISTHESIS. *756.11 CONGENITAL SPONDYLOLYSIS LUMBOSACRAL REGION. *756.12 SPONDYLOLISTHESIS CONGENITAL. * ...
This work aims to integrate information acquired from pre-operative brain mapping with intra-operative brain mapping and intra- ... Transcranial MR-Guided Focused Ultrasound and Hyperostosis Calvariae Diffusa: Case Report and Systematic Review of the ... direct electrical stimulation and clinical disconnection syndromes. Brain Struct Funct. 2022 Jun; 227(5):1545-1564.. View in: ... cross-validate information acquired through different techniques, and gain a better understanding of the relationship between ...
  • cranial hyperostosis, or other conditions. (msdmanuals.com)
  • There is predominance of bone symptoms, including osteosclerosis, fractures after minimal trauma (usually of the ribs and long bones), osteomyelitis (especially of the jaw) and cranial hyperostosis. (orthopedicshealth.com)
  • Beretta-Piccoli BC et al (2000) Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature. (springer.com)
  • SAPHO syndrome is a rare and often unrecognized disease with prominent inflammatory cutaneous and articular symptoms characterized by musculoskeletal manifestations (synovitis, hyperostosis, osteomyelitis) associated with dermatological conditions (severe acne and pustulosis). (unicatt.it)
  • 4. Patients with SAPHO (Synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. (who.int)
  • Overview of Lysosomal Storage Disorders Lysosomal enzymes break down macromolecules, either those from the cell itself (eg, when cellular structural components are being recycled) or those acquired outside the cell. (msdmanuals.com)
  • Capsule?CAPD: Continuous ambulatory peritoneal dialysis?Caps: Capsules?CAPS: Cryopyrin-Associated Periodic Syndromes disorders?CAPTIA Syph G: ?CAPTIA Syph M: ?CAST: Cardiac arrhythmia suppression trials?CAT: Computerized axial tomography?Cataplasm. (kuwaitpharmacy.com)
  • Amital H, Applbaum YH, Aamar S et al (2004) SAPHO syndrome treated with pamidronate: an open-label study of 10 patients. (springer.com)
  • Earwaker JW et al (2003) SAPHO: syndrome or concept? (springer.com)
  • Hayem G et al (1999) SAPHO syndrome: a long-term follow-up study of 120 cases. (springer.com)
  • The acidic soluble fraction of whole saliva from 10 adult women affected by SAPHO syndrome and from a group of 28 healthy women was analysed by RP-HPLC-ESI-MS with the aim of discovering salivary biomarkers of the disorder. (unicatt.it)
  • The high expression of this pro-inflammatory protein is probably related to the inflammatory response and to the altered neutrophil responses to functional stimuli that characterize SAPHO syndrome suggesting a possible application as a salivary biomarker. (unicatt.it)
  • 11. Increased risk of infectious complications (e.g. recent pyogenic infection, any congenital or acquired immunodeficiency (e.g. (who.int)
  • Macrocephaly can be the first manifestation of various congenital and acquired neurologic conditions or may be just a familial trait. (medscape.com)
  • It can also be a feature of various congenital syndromes and is then referred to as syndromic macrocephaly. (medscape.com)
  • Note disproportionately short stature with mesomelic shortening and deformities of forearms and legs (in mesomelic dysplasia) and short forearms with Madelung-type deformity (in Leri-Weill syndrome). (medscape.com)
  • A syndrome inherited as an autosomal recessive trait and incompatible with life. (rush.edu)
  • Life-threatening complications mainly include, but are not limited to, cardiovascular/cytokine driven shock, pulmonary distress syndrome, or acute renal failure. (who.int)
  • Short Rib-Polydactyly Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "Short Rib-Polydactyly Syndrome" by people in this website by year, and whether "Short Rib-Polydactyly Syndrome" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "Short Rib-Polydactyly Syndrome" by people in Profiles. (rush.edu)
  • Brother and sister with mesomelic dysplasia (homozygous dyschondrosteosis gene) and a woman with Leri-Weill syndrome. (medscape.com)
  • In some mutations, diabetes is accompanied by severe neurological symptoms [developmental delay, epilepsy, neonatal diabetes (DEND) syndrome]. (go.jp)
  • Auriculocondylar syndrome (ARCND), also known as 'question-mark ear syndrome' or 'dysgnathia complex,' is a craniofacial malformation syndrome characterized by highly variable mandibular anomalies, including mild to severe micrognathia, often with temporomandibular joint ankylosis, cleft palate, and a distinctive ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark. (nih.gov)
  • Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)
  • We use multiple functional brain mapping techniques (fMRI, diffusion tensor imaging, and intracranial EEG) and structural and molecular imaging techniques to better define individual functional anatomy in patients with neurosurgical diseases, cross-validate information acquired through different techniques, and gain a better understanding of the relationship between these different brain signals. (dana-farber.org)
  • They may involve only a single, specific site (eg, cleft lip, cleft palate, clubfoot) or be part of a syndrome of multiple. (msdmanuals.com)
  • This review focuses on mutations of Kir6.2, the pore-forming subunit and sulfonylurea receptor (SUR) 1, the regulatory subunit of the K ATP channel, which cause neonatal diabetes/DEND syndrome and also discusses the findings of the pathological mechanisms that are associated with neonatal diabetes, and its neurological features. (go.jp)
  • This work aims to integrate information acquired from pre-operative brain mapping with intra-operative brain mapping and intra-operative imaging to define functional brain anatomy for surgical planning. (dana-farber.org)
  • 2012). For a discussion of genetic heterogeneity of auriculocondylar syndrome, see ARCND1 (602483). (nih.gov)
  • Pathologic Study of Supernumerary Orbital Band in Type I Duane Syndrome. (ucla.edu)
  • Morpho-radiological and brain endocast analysis in the study of Hyperostosis Frontalis Interna (HFI): A combined approach. (edu.au)
  • Child with Hurler syndrome (mucopolysaccharidosis type IH). (medscape.com)
  • Child with Robinow syndrome. (medscape.com)
  • In 1962, when C. Henry Kempe and his colleagues published the provocatively entitled article, "The Battered Child Syndrome," the modern acknowledgment of child abuse began in the United States. (elinewberger.com)
  • A doctor's status can have a very useful effect in getting protective service workers and agencies, for example, to do the right thing and in acquiring such vital services as child care for a family. (elinewberger.com)
  • Freyschmidt J et al (1998) The bullhead sign: scintigraphic pattern of sternocostoclavicular hyperostosis and pustulotic arthroosteitis. (springer.com)
  • Warm?CALM: Café aulait macules?cANCA: Cytoplasmic pattern of ANCA?CAP: Community-acquired pneumonia?cap. (kuwaitpharmacy.com)
  • Synthesis of 13 personal observations of sternocostoclavicular hyperostosis and 300 cases from the literature. (springer.com)
  • Gigantism and Acromegaly Gigantism and acromegaly are syndromes of excessive secretion of growth hormone (hypersomatotropism) that are nearly always due to a pituitary adenoma. (msdmanuals.com)
  • Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). (medscape.com)
  • The primary diagnoses were rheumatoid arthritis (n = 61), ankylosing spondylitis (n = 21), psoriasis (n = 10), Crohn disease (n = 8), SAPHO (synovitis acne pustulosis hyperostosis osteitis) syndrome (n = 3), psoriatic arthritis (n = 2), and other diagnoses (n = 15). (nih.gov)
  • The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. (nih.gov)
  • bowel bypass syndrome a syndrome of dermatosis and arthritis occurring some time after jejunoileal bypass, probably caused by immune reponse to bacterial overgrowth in the bypassed bowel. (topgrowupclinic.eu)
  • acquired immune deficiency syndrome , acquired immunodeficiency syndrome an epidemic, transmissible retroviral disease caused by infection with the human immunodeficiency virus, manifested in severe cases as profound depression of cell-mediated immunity, and affecting certain recognized risk groups. (topgrowupclinic.eu)
  • Bernard-Soulier syndrome a hereditary coagulation disorder marked by mild thrombocytopenia, giant and morphologically abnormal platelets, hemorrhagic tendency, prolonged bleeding time, and purpura. (topgrowupclinic.eu)
  • Börjeson's syndrome , Börjeson-Forssman-Lehmann syndrome a hereditary syndrome, transmitted as an X-linked recessive trait, characterized by severe mental retardation, epilepsy, hypogonadism, hypometabolism, marked obesity, swelling of the subcutaneous tissues of the face, and large ears. (topgrowupclinic.eu)
  • Aarskog syndrome , Aarskog-Scott syndrome a hereditary X-linked condition characterized by ocular hypertelorism,anteverted nostrils, broad upper lip, peculiar scrotal "shawl" above the penis, and small hands. (topgrowupclinic.eu)
  • Camurati-Engelmann Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • battered-child syndrome multiple traumatic lesions of the bones and soft tissues of children, often accompanied by subdural hematomas, willfully inflicted by an adult. (topgrowupclinic.eu)
  • Beckwith-Wiedemann syndrome an inherited disorder characterized by exomphalos, macroglossia, and gigantism, often associated with visceromegaly, adrenocortical cytomegaly, and dysplasia of the renal medulla. (topgrowupclinic.eu)
  • Birt-Hogg-Dubé syndrome an inherited disorder of proliferation of ectodermal and mesodermal components of the pilar system, occurring as multiple trichodiscomas, acrochordons, and fibrofolliculomas on the head, chest, back, and upper limbs. (topgrowupclinic.eu)
  • Females: Classic Rett syndrome, a progressive neurodevelopmental disorder primarily affecting girls, is characterized by apparently normal psychomotor development during the first six to 18 months of life, followed by a short period of developmental stagnation, then rapid regression in language and motor skills, followed by long-term stability. (beds.ac.uk)
  • People who consume alcohol and smoke cigarettes (which are high calcium stealers) run a higher risk of acquiring bone diseases. (medindia.net)
  • The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome. (nih.gov)
  • Hidrotic ectodermal dysplasia 2, or Clouston syndrome (referred to as HED2 throughout this GeneReview) is characterized by a triad of major clinical features including partial-to-complete alopecia, nail dystrophy, and palmoplantar hyperkeratosis. (beds.ac.uk)
  • bradycardia-tachycardia syndrome , brady-tachy syndrome a clinical manifestation of the sick sinus syndrome characterized by alternating periods of bradycardia and tachycardia. (topgrowupclinic.eu)
  • the spectrum in males ranges from severe neonatal encephalopathy to pyramidal signs, parkinsonism, and macroorchidism (PPM-X) syndrome to severe syndromic/nonsyndromic intellectual disability. (beds.ac.uk)
  • 4 ⇓ - 6 Carpal and tarsal tunnel syndromes represent the most common features of peripheral nervous system impairment. (ajnr.org)
  • Warm?CALM: Café aulait macules?cANCA: Cytoplasmic pattern of ANCA?CAP: Community-acquired pneumonia?cap. (kuwaitpharmacy.com)
  • Tumors, either originating in the neural structures themselves or metastatic may also give rise to cauda equina syndrome due to compression of the cauda equina by tumor growth or expansion from hemorrhage. (tristateneurologicalsurgeons.com)
  • basal cell nevus syndrome an autosomal dominant syndrome characterized by the development in early life of numerous basal cell carcinomas, in association with abnormalities of the skin, bone, nervous system, eyes, and reproductive tract. (topgrowupclinic.eu)
  • Proteus syndrome - due to activating mutations in AKT1 oncogene (or occasionally PTEN mutations). (rxharun.com)
  • Gardner syndrome - is due to autosomal dominant mutations in the adenomatous polyposis coli (APC) gene. (rxharun.com)
  • Cowden syndrome - is due to mutations in PTEN and is associated with multiple lipomas, facial trichilemmomas, oral papillomas, punctate palmoplantar keratoses, and a variety of malignancies including breast adenocarcinoma, thyroid follicular carcinoma, endometrial carcinomas, and hamartomatous polyps of the gastrointestinal tract. (rxharun.com)
  • Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)
  • Direct trauma from penetrating injuries or bullet wounds may lead to cauda equina syndrome, Lumbar puncture can also cause cauda equina syndrome. (tristateneurologicalsurgeons.com)
  • blue toe syndrome skin necrosis and ischemic gangrene manifest as a blue color of the toes, resulting from arterial occlusion, usually caused by emboli, thrombi, or injury. (topgrowupclinic.eu)
  • Budd-Chiari syndrome symptomatic obstruction or occlusion of the hepatic veins, causing hepatomegaly, abdominal pain and tenderness, intractable ascites, mild jaundice, and eventually portal hypertension and liver failure. (topgrowupclinic.eu)
  • This graph shows the total number of publications written about "Camurati-Engelmann Syndrome" by people in UAMS Profiles by year, and whether "Camurati-Engelmann Syndrome" was a major or minor topic of these publications. (uams.edu)
  • Barrett's syndrome peptic ulcer of the lower esophagus, often with stricture, due to the presence of columnar-lined epithelium, which may contain functional mucous cells, parietal cells, or chief cells, in the esophagus instead of normal squamous cell epithelium. (topgrowupclinic.eu)