Acute Radiation Syndrome

Radioactive Hazard Release

Radiation Injuries, Experimental

Radiation Injuries

Whole-Body Irradiation

Radiation-Protective Agents

Radiation Dosage

Lethal Dose 50

Dose-Response Relationship, Radiation

Radiodermatitis

Syndrome

Radiation Pneumonitis

Acute radiation syndrome

Treatment of infections after exposure to ionizing radiation

Sargramostim

Rongelap Atoll

List of civilian radiation accidents

Chronic radiation syndrome

Background radiation

Louis Slotin

Sunburn

Radiation-induced lung injury

Fukushima Daiichi nuclear disaster casualties

Romiplostim

Nuclear testing at Bikini Atoll

Dose fractionation

List of orphan source incidents

Volodymyr Pravyk

Chernobyl disaster

Maria Orbeli

Louis Hempelmann

Effective dose (radiation)

Radiation-induced cancer

Radiobiology

Nuclear warfare

May 1953

Aleksandr Akimov

Committed dose

Oishi Matashichi

Daigo Fukuryū Maru

Capture of Chernobyl

Poisoning of Alexander Litvinenko

Sickness24

• Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
• Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation in a short period of time. (wikipedia.org)
• These symptoms are common to many illnesses, and may not, by themselves, indicate acute radiation sickness. (wikipedia.org)
• Depending on the dose of radiation received, individuals develop acute radiation syndrome (ARS, also known as radiation sickness). (therasourceinc.com)
• A targeted look at the effects of radiation sickness and what measures to take for decontamination and initial treatment. (emra.org)
• Radiation sickness is damage to your body caused by a large dose of radiation often received over a short period of time (acute). (sparrow.org)
• Radiation sickness is also called acute radiation syndrome or radiation poisoning. (sparrow.org)
• Radiation sickness is not caused by common imaging tests that use low-dose radiation, such as X-rays or CT scans. (sparrow.org)
• Although radiation sickness is serious and often fatal, it's rare. (sparrow.org)
• Since the atomic bombings of Hiroshima and Nagasaki, Japan, during World War II, most cases of radiation sickness have occurred after nuclear industrial accidents, such as the 1986 explosion and fire that damaged the nuclear power plant at Chernobyl, Ukraine. (sparrow.org)
• The severity of signs and symptoms of radiation sickness depends on how much radiation you've absorbed. (sparrow.org)
• The severity of radiation sickness also depends on how sensitive the affected tissue is. (sparrow.org)
• The initial signs and symptoms of treatable radiation sickness are usually nausea and vomiting. (sparrow.org)
• After the first round of signs and symptoms, a person with radiation sickness may have a brief period with no apparent illness, followed by the onset of new, more-serious symptoms. (sparrow.org)
• An accident or attack that causes radiation sickness would no doubt cause a lot of attention and public concern. (sparrow.org)
• Radiation sickness is caused by exposure to a high dose of radiation, such as a high dose of radiation received during an industrial accident. (sparrow.org)
• Radiation sickness occurs when high-energy radiation damages or destroys certain cells in your body. (sparrow.org)
• The company said it is helping to ramp up supply in Europe of Leukine, a drug to treat acute radiation syndrome (ARS), or radiation sickness from exposure to high dose radiation during a nuclear emergency. (localnews8.com)
• Symptoms may be local (eg, burns) or systemic (eg, acute radiation sickness). (msdmanuals.com)
• Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (msdmanuals.com)
• A short-term dose of 1000 mSv (1 Sv) is about the threshold of acute radiation syndrome (sickness). (world-nuclear.org)
• High levels of exposure can cause acute radiation sickness, a syndrome first recognized by the medical profession after Hiroshima and Nagasaki. (helencaldicott.com)
• About $56.3 million will go toward five contracts for a variety of drug companies and scientists working on countermeasures for acute radiation syndrome, or radiation sickness. (dotmed.com)
• In 2020, Jacob and colleagues published data demonstrating the effectiveness of a novel miRNA-based biodosimetry test devised to quickly diagnose radiation sickness based on biomarkers measured through a single drop of blood. (eurekalert.org)

Doses25

• o Fractionated doses are often used in radiation therapy. (cdc.gov)
• It is generally divided into three types: bone marrow, gastrointestinal, and neurovascular syndrome, with bone marrow syndrome occurring at 0.7 to 10 Gy, and neurovascular syndrome occurring at doses that exceed 50 Gy. (wikipedia.org)
• ARS differs from chronic radiation syndrome, which occurs following prolonged exposures to relatively low doses of radiation. (wikipedia.org)
• The speed of symptom onset is related to radiation exposure, with greater doses resulting in a shorter delay in symptom onset. (wikipedia.org)
• This syndrome often follows absorbed doses of 6-30 grays (600-3,000 rad). (wikipedia.org)
• This syndrome typically occurs at absorbed doses greater than 30 grays (3,000 rad), though it may occur at doses as low as 10 grays (1,000 rad). (wikipedia.org)
• These symptoms may occur at radiation doses as low as 0.35 grays (35 rad). (wikipedia.org)
• Exposure to high doses of ionizing radiation can cause lethal injury to normal tissue, thus inducing acute radiation syndrome. (bioone.org)
• Absorbed and equivalent radiation doses can not be directly converted as the conversion depends on the type of radiation. (convert-me.com)
• Exposure to high doses of radiation can occur after accidental exposure to radioactive materials, a natural disaster or technical accident at a nuclear facility, or the detonation of a radioactive device or nuclear bomb. (therasourceinc.com)
• Patients with Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS): Nplate is indicated to increase survival in adults and pediatric patients (including term neonates) acutely exposed to myelosuppressive doses of radiation. (orau.gov)
• Increase survival in patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Subsyndrome of Acute Radiation Syndrome). (drugs.com)
• Administer the first dose as soon as possible after suspected or confirmed exposure to myelosuppressive doses of radiation, and a second dose one week after. (drugs.com)
• Pegfilgrastim is used to reduce the risk of infection in some cancer patients and to increase your chances of surviving after exposure to high doses of radiation that affect your ability to make blood cells. (drugs.com)
• They are not approved for use in people acutely exposed to myelosuppressive doses of radiation. (drugs.com)
• Patients receiving high doses of radiation can't produce enough new white blood cells, red blood cells, and platelets, which is called myelosuppression. (pharmalive.com)
• For example, many workers have been harmed as a result of long-term exposure to small doses of radiation on the job while others have suffered radiation poisoning from being exposed to a radiation source after one time. (injurylawservice.com)
• In 1999 three workers received high doses of radiation in a small Japanese plant preparing fuel for an experimental reactor. (world-nuclear.org)
• A total of 119 people received a radiation dose over 1 mSv from the accident, but only the three operators' doses were above permissible limits. (world-nuclear.org)
• If a meltdown occurred at the plant, a large number of people could be exposed to high doses of radiation in this region, one of the most heavily populated in Japan. (helencaldicott.com)
• When exposed to high doses of ionizing radiation -- such as from a nuclear bomb blast -- fast-reproducing cells in the gut, bone marrow, and lungs can be destroyed, which can in turn lead to internal bleeding, a depressed immune system and death over the following days or even weeks. (dotmed.com)
• In tests on animals, the substance, which mimics a hormone found in the body and prevents cell death and inflammation, was found to protect against lethal doses of radiation, as well as to speed up wound healing, reduce brain, kidney and heart injuries from trauma or disease, and even improve learning. (dotmed.com)
• The study aimed to estimate threshold doses and their uncertainties for some human health effects after short-term high dose-rate radiation exposure by quantile technique and the effective dose threshold technique based on distribution functions. (bvsalud.org)
• The quantile technique provided statistically significant estimates of threshold doses for acute radiation syndrome onset (0.44 ± 0.12 Gy, U = 143%) and lethality (1.84 ± 0.44 Gy, U = 117%) but relative uncertainties were high. (bvsalud.org)
• Threshold doses estimated for the change in the peripheral blood neutrophil and leukocyte counts during the first days after short-term high dose-rate radiation exposure were not statistically significant. (bvsalud.org)

Treat acute radiatio3

• The purpose of this draft guidance is to provide information and recommendations to assist sponsors and other interested parties in the development of drugs to prevent or treat acute radiation syndrome ( ARS ) caused by exposure to ionizing radiation from accidental or deliberate events. (govdelivery.com)
• But Leukine (whose generic name is sargramostim) is not currently approved for use in Europe to treat acute radiation syndrome. (localnews8.com)
• A $290 million procurement of the drug Nplate, to treat acute radiation syndrome (ARS), was announced by the US Health and Human Services (HSS). (onecitizenspeaking.com)

Myeloid Leukemia1

• Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Monitor patients with breast and lung cancer using UDENYCA in conjunction with chemotherapy and/or radiotherapy for signs and symptoms of MDS/AML. (drugs.com)

Injuries9

• The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)
• Our novel approach of DRCC transplantation may act as a bridging therapy supporting hematopoietic recovery and ameliorating injuries in patients exposed to the harmful effects of radiation. (aaps1921.org)
• This consensus document was developed by the Strategic National Stockpile Radiation Working Group to provide a framework for physicians in internal medicine and the medical subspecialties to evaluate and manage large-scale radiation injuries. (nebraska.edu)
• In the case of a radiological or nuclear public health emergency, many thousands of people could experience severe injuries from radiation exposure, resulting in immunosuppression and infection, hemorrhage, major morbidities, and even death. (orau.gov)
• Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (iu.edu)
• The IAEA in a 2020 publication titled " Medical Management of Radiation Injuries ," referenced sargramostim as a treatment for radiation emergencies in adults. (localnews8.com)
• Employees suffer injuries on the job that can occur from a number of job-related dangers, such as radiation exposure. (injurylawservice.com)
• Unfortunately, as the use of radiation products and equipment increases, so does the number of work-related radiation injuries and illnesses. (injurylawservice.com)
• Although definitive treatment of radiation injuries should involve consultation with specialists, nonspecialists should learn to recognize the distinctive signs of radiation injury and make an initial assessment of severity of exposure. (bvsalud.org)

Diagnosis7

• The DelveInsight's Acute Radiation Syndrome market report gives a thorough understanding of the Acute Radiation Syndrome by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis, and Acute Radiation Syndrome treatment. (delveinsight.com)
• Diagnosis and Treatment Interstitial Cystitis/Bladder Pain Syndrome (2022). (medlineplus.gov)
• Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment. (medlineplus.gov)
• The DelveInsight Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) market report gives a thorough understanding of the Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis and treatment. (marketresearch.com)
• Diagnosis is by history of exposure, symptoms and signs, and sometimes use of radiation detection equipment to localize and identify radionuclide contamination. (msdmanuals.com)
• Burning mouth syndrome (BMS) is a clinical diagnosis made via the exclusion of all other causes. (medscape.com)
• This article reviews the diagnosis and treatment of acute radiation syndrome. (bvsalud.org)

Bone9

• Acute radiation syndrome is caused by depletion of bone marrow cells (hematopoietic syndrome) and irreparable damage to the epithelial cells in the gastrointestinal tract (gastrointestinal syndrome). (bioone.org)
• ARS is an illness that occurs following a high dose of radiation exposure, leading to severe damage to the bone marrow and the immune system. (nwahomepage.com)
• For instance, the gastrointestinal system and bone marrow are highly sensitive to radiation. (sparrow.org)
• Regions of the body most vulnerable to high-energy radiation are cells in the lining of your intestinal tract, including your stomach, and the blood cell-producing cells of bone marrow. (sparrow.org)
• Myelosuppression happens when radiation damages internal organs, including bone marrow. (pharmalive.com)
• PLX-RAD will be used for treatment of bone marrow deficiency, genetic diseases, and treatment of acute radiation syndrome. (israel21c.org)
• Most hospitals in the US maintain some supply of radiation exposure treatment drugs like Leukine, which is a prescription medication and is given by medical professionals to patients, said Dr. Nelson Chao, professor of medicine and immunology and chief of the division of cellular therapy and bone marrow transplant at Duke University. (localnews8.com)
• Many types of cancer can occur as a result of radiation on the job, such as bone cancer, lung cancer and skin cancer. (injurylawservice.com)
• Also called HemaMax, a 2008 BARDA-funded study showed it might be able to protect bone marrow from radiation. (dotmed.com)

Radioactive8

• If the substance is radioactive, you may also be exposed to radiation if you are near it. (cdc.gov)
• Naturally occurring sources of radiation are cosmic radiation from space or radioactive materials in soil or building materials. (cdc.gov)
• Radioactive fallout poses the greatest threat to people during the first two weeks, by which time it has declined to about 1 percent of its initial radiation level. (lifehacker.com)
• Radioactive materials are used in the industrial sector, and radiation producing equipment is increasingly used in a number of different industries. (injurylawservice.com)
• Ionizing radiation is emitted by radioactive elements and by equipment such as x-ray and radiation therapy machines. (msdmanuals.com)
• Scientists note that exposure to radiation through unintentional contact with radioactive material (e.g., natural environmental or occupational settings) or through intentional release of a radioactive material (e.g., terrorist attack) could lead to serious health problems. (eurekalert.org)
• medical equipment and consumer products, radiation therapy ` The general population is rarely exposed to radioactive for treating cancer patients, manufacturing plastics, and cobalt unless a person is undergoing radiation therapy. (cdc.gov)
• Cancer has been shown, however, in animals that breathed is to see if you have been exposed to a large dose of cobalt or when cobalt was placed directly into the muscle or radiation, and the other is to see if radioactive cobalt is in under the skin. (cdc.gov)

Patients7

• 4 o The survival rate of patients with this syndrome decreases with increasing dose. (cdc.gov)
• Acute Radiation Syndrome in an Irradiated Minipig Model for Patients with Radiation Exposure. (capsulehealth.one)
• Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever, lung infiltrates, or respiratory distress. (drugs.com)
• But the injectable medication can also be administered as a life-saving measure for patients exposed to dangerous levels of radiation outside of medical treatment: The drug can increase the chances of survivability if given in the critical 48 to 96 hours after initial exposure to a high dose of radiation from a nuclear blast or nuclear fallout. (localnews8.com)
• Type 1 burning mouth syndrome (BMS): Patients have no symptoms upon waking, with progression throughout the day. (medscape.com)
• Type 2 burning mouth syndrome (BMS): Patients have continuous symptoms throughout the day and are frequently asymptomatic at night. (medscape.com)
• Type 3 burning mouth syndrome (BMS): Patients have intermittent symptoms throughout the day and symptom-free days. (medscape.com)

Countermeasures1

• While effective medical countermeasures (MCM) for the hematopoietic-acute radiation syndrome (H-ARS) have been identified and approved by the FDA, development of MCM for DEARE has not yet been successful. (bvsalud.org)

20231

• ROCKVILLE, Md , Nov. 20, 2023 /PRNewswire/ -- NeoImmuneTech, Inc. (NIT or "NeoImmuneTech"), a clinical-stage T cell-focused biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for their investigational drug NT-I7 (efineptakin alfa) (rhIL-7-hyFc) for the treatment of Acute Radiation Syndrome (ARS). (nwahomepage.com)

Nuclear6

• Victims of nuclear disasters present with acute radiation syndrome as a result of exposure to ionizing radiation. (aaps1921.org)
• In an emergency situation, such as a nuclear attack, he said first responders would quickly administer the drug to as many people as possible who've encountered extreme radiation exposure. (localnews8.com)
• Hopefully that would be within 24 hours," said Chao who is also a member of the Radiation Injury Treatment Network, a national network of medical centers with expertise managing acute radiation syndrome following a mass casualty disaster involving radiological, nuclear, or chemical agents. (localnews8.com)
• At the point of criticality, the nuclear fission chain reaction became self-sustaining and began to emit intense gamma and neutron radiation, triggering alarms. (world-nuclear.org)
• The US government has purchased a significant supply of radiation-injury drugs as the Russian president threatened the use of nuclear weapons. (onecitizenspeaking.com)
• One Medical Hazards Manage- ated with acute chemical or radio-nuclear thyroid cancer mortality of an additional ment Team (HazMaT) has been estab- events. (who.int)

Severe acute re2

• The outbreak of severe acute respiratory syndrome in 2002-2003 exacted considerable human and economic costs from countries involved. (cdc.gov)
• The causal agent of this disease was found to be a coronavirus, and the disease was named severe acute respiratory syndrome (SARS) ( 1 ). (cdc.gov)

Irradiation2

• Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to <10 Gy Total Body Irradiation. (iu.edu)
• Various radiation exposure scenarios (i.e. total body irradiation, total abdominal irradiation, etc.) have been used to investigate ionizing radiation-induced gastrointestinal injury. (bvsalud.org)

Hiroshima and Naga2

• Effect on intelligence test score of prenatal exposure to ionizing radiation in Hiroshima and Nagasaki: A comparison of the T65DR and DS86 dosimetry systems. (cdc.gov)
• The aftermaths of Hiroshima and Nagasaki offered a glimpse of the hazards, and a Nobel Prize-winning 1946 study connected x-ray radiation to human mutations. (theverge.com)

Hematopoietic system1

• Transplantation of DRCC after ionizing radiation exposure proved to be the most effective rescue therapy against acute radiation syndrome, as confirmed by 100% of recipients' survival and expedited recovery of the hematopoietic system without developing GVHD. (aaps1921.org)

Department of Radiation Oncology1

• This work is particularly important because of the possible major health consequences of radiation exposure, including cancer and other illnesses," said Jacob, an associate professor in the Department of Radiation Oncology at The Ohio State University College of Medicine and a member of the OSUCCC - James Translational Therapeutics Research Program. (eurekalert.org)

Onset1

• Individual radiation dose is assessed by determining the time to onset and severity of nausea and vomiting, decline in absolute lymphocyte count over several hours or days after exposure, and appearance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocytes. (nebraska.edu)

Biomarkers5

• Prognostic biomarkers for acute graft-versus-host disease risk after cyclophosphamide-fludarabine nonmyeloablative allotransplantation. (iu.edu)
• COLUMBUS, Ohio - Researchers with The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) have entered a federal cooperative agreement, valued up to $9.42 million, that will help them further develop Ohio State's biodosimetry technology to discover noninvasive biomarkers for radiation exposure - work that will have national security applications. (eurekalert.org)
• Under Jacob's leadership, the OSUCCC - James team will work to develop rapid and accurate radiation biodosimetry solutions to human radiation exposure based on biomarkers that are detectable in skin and hair and that can be collected non-invasively. (eurekalert.org)
• This new collaborative research effort is aimed at developing a non-invasive method to measure radiation exposure levels rapidly and accurately through biomarkers detectable in skin and hair, which could be especially useful and impactful in military settings. (eurekalert.org)
• These radiation-induced gastrointestinal severity scoring systems are based on clinical signs and symptoms and gastrointestinal-specific biomarkers (i.e. citrulline, etc. (bvsalud.org)

Exposures2

• How much you absorb depends on the strength of the radiated energy, the time of your exposures, and the distance between you and the source of radiation. (sparrow.org)
• Sadly, workplace exposures to ionizing radiation has resulted in leukemia and death. (injurylawservice.com)

Symptoms4

• the full syndrome will usually occur with a dose greater than approximately 0.7 Gy (70 rads) although mild symptoms may occur as low as 0.3 Gy or 30 rads. (cdc.gov)
• The signs and symptoms of this form of radiation injury include nausea, vomiting, loss of appetite, and abdominal pain. (wikipedia.org)
• The amount of time between exposure and when these symptoms develop is a clue to how much radiation a person has absorbed. (sparrow.org)
• Various attempts to classify burning mouth syndrome (BMS) based on etiology and symptoms have been made. (medscape.com)

Lethal2

• NIAID -sponsored studies demonstrated that administration of Nplate®, originally licensed in 2008 for treatment of immune thrombocytopenia, increased platelet counts and improved survival in preclinical models of lethal radiation exposure. (orau.gov)
• The cause of death was acute radiation syndrome (ARS) resulting from a lethal polonium-210 poison attack. (nationofchange.org)

20192

• The Acute Radiation Syndrome market report provides current treatment practices, emerging drugs, Acute Radiation Syndrome market share of the individual therapies, current and forecasted Acute Radiation Syndrome market Size from 2019 to 2032 segmented by seven major markets. (delveinsight.com)
• The disease epidemiology covered in the report provides historical as well as forecasted Acute Radiation Syndrome epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032. (delveinsight.com)

Severity3

• Depending on the radiation levels will determine the severity of damage. (injurylawservice.com)
• PURPOSE: Severity scoring systems for ionizing radiation-induced gastrointestinal injury have been used in animal radiation models, human studies involving the use of radiation therapy, and human radiation accidents. (bvsalud.org)
• This tool provides a triage diagnostic approach to assist first responders to assess individuals suspected of showing gastrointestinal acute radiation syndrome severity to guide medical management, hence enhancing medical readiness for managing radiological casualties. (bvsalud.org)

Treatment17

• The Biomedical Advanced Research and Development Authority (BARDA) exercised $6 million in additional contract options under its advanced research and development contract with Aeolus Pharmaceuticals for AEOL-10150, a broad-spectrum catalytic antioxidant specifically designed to neutralize reactive oxygen and nitrogen species, as a treatment for the pulmonary syndrome of acute radiation syndrome (Lung-ARS) and delayed effects of acute radiation exposure (DEARE). (genengnews.com)
• The FDA's Orphan Drug Designation is aimed at advancing treatments for rare diseases, including Acute Radiation Syndrome (ARS), which currently has limited treatment options. (nwahomepage.com)
• The Report also covers current Acute Radiation Syndrome treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Acute Radiation Syndrome market. (delveinsight.com)
• It covers the details of conventional and current medical therapies available in the Acute Radiation Syndrome market for the treatment of the condition. (delveinsight.com)
• It also provides Acute Radiation Syndrome treatment algorithms and guidelines in the United States, Europe, and Japan. (delveinsight.com)
• Recommendations based on radiation dose and physiologic response are made for treatment of the hematopoietic syndrome. (nebraska.edu)
• FDA announced availability of a draft guidance for industry, Acute Radiation Syndrome: Developing Drugs for Prevention and Treatment . (govdelivery.com)
• The Report also covers current Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market. (marketresearch.com)
• It covers the details of conventional and current medical therapies available in the Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) market for the treatment of the condition. (marketresearch.com)
• It also provides Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) treatment algorithms and guidelines in the United States, Europe, and Japan. (marketresearch.com)
• The report provides the details of the marketed product available for Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) treatment. (marketresearch.com)
• The report provides the details of the emerging therapies under the late and mid-stage of development for Non-ST Segment Elevation Acute Coronary Syndromes (NSTE ACSs) treatment. (marketresearch.com)
• and treatment of acute radiation syndrome (ARS) in conjunction with the US National Institutes of Health's National Institute of Allergy and Infectious Diseases. (israel21c.org)
• Amgen did not respond to requests for comment about whether the company is increasing supplies of its acute radiation exposure treatment drugs. (localnews8.com)
• In addition to the COPD trail, Osiris is also conducting Phase II Prochymal trials for the treatment of acute myocardial infarction and type 1 diabetes. (wtnnews.com)
• The therapy also is being developed as a potential treatment for acute radiation syndrome. (wtnnews.com)
• The ambiguous definition of burning mouth syndrome (BMS) makes evaluation of prognosis and treatment difficult. (medscape.com)

Occur2

• Sources of such radiation can occur accidentally or intentionally. (wikipedia.org)
• External exposure to radiation may occur from natural or man-made sources. (cdc.gov)

Amount of radiation2

• The amount of radiation absorbed by the body - the absorbed dose - determines how sick you'll be. (sparrow.org)
• Won't a tiny amount of radiation kill you? (greanvillepost.com)

Therapies1

• Therefore there is an urgent need to develop new effective therapies of acute radiation syndrome. (aaps1921.org)

Gastrointestinal syndrome1

• Each syndrome requires that the tissue showing the syndrome itself be exposed (e.g., gastrointestinal syndrome is not seen if the stomach and intestines are not exposed to radiation). (wikipedia.org)

Rescue1

• CONCLUSIONS: A worksheet tool was developed to prioritize individuals with severe life-threatening gastrointestinal acute radiation syndrome, based on the design of the Exposure and Symptom Tool addressing hematopoietic acute radiation syndrome, to rescue individuals from potential gastrointestinal acute radiation syndrome injury. (bvsalud.org)

Detection2

• Crystalline cesium iodide and cesium fluoride are used in scintillation counters, which convert energy from ionizing radiation into pulses of visible light for radiation detection and spectroscopy. (cdc.gov)
• The project expands upon ongoing efforts by OSUCCC - James scientists to develop blood biomarker-based mechanisms for early detection of acute radiation syndromes and delayed effects. (eurekalert.org)

Chronic radiation syndrome2

• Chronic radiation syndrome. (injurylawservice.com)
• With chronic radiation syndrome, workers are exposed to ionizing radiation for months or years. (injurylawservice.com)

Suffer3

• When workers are exposed to high amounts of ionizing radiation, they can suffer gastrointestinal problems, destruction of cells, tissue damage, neurological problems, and even death, usually within 24 hours of exposure. (injurylawservice.com)
• When people are exposed to both microwave and ionizing radiation, they can suffer cataracts, which is when the lens of the eye starts becoming opaque and results in blurred vision. (injurylawservice.com)
• Survivors of acute radiation exposure suffer from the delayed effects of acute radiation exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney, heart, gastrointestinal tract, eyes, and brain, and often causing cancer. (bvsalud.org)

Effects3

• Neutron or proton radiation produces many of the health effects described herein at lower absorbed dose levels. (cdc.gov)
• Being able to determine the amount and range of exposure would help clinicians more quickly and accurately mitigate the short- and long-term effects of cumulative radiation exposure," said Jacob. (eurekalert.org)
• Children are more susceptible than adults to immediate and delayed radiation health effects. (bvsalud.org)

Typically2

• Whether this is in the air or settled on the ground, it may expose people to ionizing radiation, and the effect of this is measured in Sieverts, or more typically milliSieverts (mSv). (world-nuclear.org)
• Burning mouth syndrome (BMS) is an idiopathic condition characterized by a continuous burning sensation of the mucosa of the mouth, typically involving the tongue, with or without extension to the lips and oral mucosa. (medscape.com)

Chemical1

• On March 24, one of Partner Therapeutics international distributors -Tanner Pharma Group - said in a press release that it has partnered with the drugmaker to significantly increase the drug's inventory in Europe in response to the war in Ukraine and the "escalating potential for incidents that could require rapid deployment of medical interventions to treat radiation or chemical exposure. (localnews8.com)

Ionizing Radiation6

• Ionizing radiation can also be in the form of particulate radiation, which includes subatomic l charged or neutral particles traveling near the speed of light and therefore with high very high kinetic energy. (medscape.com)
• When workers are exposed to ionizing radiation, it is possible they can develop leukemia, which is when the body produces abnormal blood cells. (injurylawservice.com)
• This type of injury is a skin disease that occurs from exposure to ionizing radiation over a prolonged period of time. (injurylawservice.com)
• Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)
• Exposure to ionizing radiation can also be by direct radiation from the plants and fuels themselves, though not released to the environment. (world-nuclear.org)
• This new research cooperative agreement is organized through the IARPA's Targeted Evaluation of Ionizing Radiation Exposure ( IARPA - TEI-REX ) program and includes four prime awardees, with Jacob serving as principal investigator of the OSU led program, where Battelle Memorial Institute is a sub-awardee. (eurekalert.org)

Electromagnetic radiation3

• Energy can travel through space in the form of electromagnetic radiation. (medscape.com)
• Electromagnetic radiation is composed of massless waves of oscillating electric and magnetic fields. (medscape.com)
• Gamma radiation and x-rays are electromagnetic radiation (ie, photons) of very short wavelength that can penetrate deeply into tissue (many centimeters). (msdmanuals.com)

Lung2

• Katherine D. Castle , Andrea R. Daniel , Everett J. Moding , Lixia Luo , Chang-Lung Lee , and David G. Kirsch "Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome," Radiation Research 189(6), 627-633, (10 April 2018). (bioone.org)
• Many people would develop acute shortness of breath from lung damage. (helencaldicott.com)

Depletion1

• The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (cdc.gov)

Classically1

• Classically, burning mouth syndrome (BMS) is accompanied by gustatory disturbances (dysgeusia, parageusia) and subjective xerostomia. (medscape.com)

20211

• With the January 28, 2021 approval of Nplate® for hematopoietic acute radiation syndrome (H-ARS), the FDA has now granted approvals for four products to treat H-ARS, three of which relied on NIAID-supported preclinical data. (orau.gov)

Neutron2

• Neutron radiation had ceased. (world-nuclear.org)
• The radiation (neutron and gamma) emanated almost entirely from the tank, not from any dispersed materials. (world-nuclear.org)

Lethality2

• Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding. (iu.edu)
• Subcutaneous wounding postirradiation reduces radiation lethality in mice. (iu.edu)

Burns4

• Conventional trauma and burns resulting from a bomb blast are complicated by the poor wound healing caused by hematopoietic syndrome, increasing mortality. (wikipedia.org)
• Gamma burns from highly penetrating gamma radiation. (capsulehealth.one)
• Beta burns would be likely all over the body caused by contact with fallout, but thermal burns are often on one side of the body as heat radiation does not penetrate the human body. (capsulehealth.one)
• Glass will shatter, possibly injuring people, paint will peel, and thermal radiation traveling the speed of light will give exposed skin third-degree burns. (lifehacker.com)

Gamma rays1

• o High energy X-rays, gamma rays, and neutrons are penetrating radiations. (cdc.gov)

High3

• People exposed to radiation may be divided into "low-risk" and "high-risk" susceptibility groups, based on degree of neutropenia and the presence of comorbidities. (msdmanuals.com)
• Acute radiation syndromes can be caused by a sufficient dose of some internally deposited radionuclides that are widely distributed in tissues and organs and have a high specific activity. (msdmanuals.com)
• N-16 has a half-life of only 7 seconds but produces high-energy gamma radiation during decay. (world-nuclear.org)