Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
Alkaloids extracted from various species of Cinchona.
A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.
A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.
Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
A genus of ascomycetous fungi, family Clavicipitaceae, order Hypocreales, parasitic on various grasses (POACEAE). The sclerotia contain several toxic alkaloids. Claviceps purpurea on rye causes ergotism.
A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.
ISOQUINOLINES with a benzyl substituent.
A plant genus of the family RANUNCULACEAE. Members contain ACONITINE and other diterpenoid alkaloids.
Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.
An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The anamorphic form of the fungus EPICHLOE. Many Neotyphodium species produce ERGOT ALKALOIDS.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE and other isoquinoline ALKALOIDS.
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.
A plant genus of the family LYCOPODIACEAE. Members contain ALKALOIDS. Lycopodium oil is obtained from L. clavatum.
A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
Lysergic acid is a crystalline ergoline alkaloid found in the fungus Claviceps purpurea, which is used as a precursor in the synthesis of medically important derivatives like LSD and ergotamine, but it also has hallucinogenic properties when ingested directly.
A genus of Eurasian herbaceous plants, the poppies (family PAPAVERACEAE of the dicotyledon class Magnoliopsida), that yield OPIUM from the latex of the unripe seed pods.
The Madder plant family of the order Rubiales, subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.
A plant genus of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta.
Alkaloids obtained from various plants, especially the deadly nightshade (Atropa belladonna), variety acuminata; atropine, hyoscyamine and scopolamine are classical, specific antimuscarinic agents with many pharmacologic actions; used mainly as antispasmodics.
Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.
A plant genus of the family APOCYNACEAE. It contains ellipticine.
The poppy plant family of the order Papaverales, subclass Magnoliidae, class Magnoliopsida. These have bisexual, regular, cup-shaped flowers with one superior pistil and many stamens; 2 or 3 conspicuous, separate sepals and a number of separate petals. The fruit is a capsule. Leaves are usually deeply cut or divided into leaflets.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The outer layer of the woody parts of plants.
A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
A series of structurally-related alkaloids that contain the ergoline backbone structure.
The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.
A species of toxic plants of the Compositae. The poisonous compounds are alkaloids which cause cattle diseases, neoplasms, and liver damage and are used to produce cancers in experimental animals.
A class of organic compounds containing four or more ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
A plant genus of the family RUBIACEAE. Members contain uncarine and other cytotoxic and hypotensive oxindole alkaloids.
A plant genus of the APOCYNACEAE or dogbane family. Alkaloids from plants in this genus have been used as tranquilizers and antihypertensive agents. RESERPINE is derived from R. serpentina.
Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.
The phylum of sponges which are sessile, suspension-feeding, multicellular animals that utilize flagellated cells called choanocytes to circulate water. Most are hermaphroditic. They are probably an early evolutionary side branch that gave rise to no other group of animals. Except for about 150 freshwater species, sponges are marine animals. They are a source of ALKALOIDS; STEROLS; and other complex molecules useful in medicine and biological research.
An order of fungi in the phylum ASCOMYCOTA that includes a number of species which are parasitic on higher plants, insects, or fungi. Other species are saprotrophic.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.
A genus of ascomycetous fungi in the family Clavicipitaceae, order HYPOCREALES, which are fungal symbionts of grasses. Anamorphic forms are in the genus NEOTYPHODIUM.
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
A plant genus of the family RUBIACEAE. Members contain antimalarial (ANTIMALARIALS) and analgesic (ANALGESICS) indole alkaloids.
A beta-carboline alkaloid isolated from seeds of PEGANUM.
One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.
Compounds of four rings containing a nitrogen. They are biosynthesized from reticuline via rearrangement of scoulerine. They are similar to BENZYLISOQUINOLINES. Members include chelerythrine and sanguinarine.
A plant genus of the family FUMARIACEAE (classified by some in PAPAVERACEAE) that contains isoquinoline alkaloids.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A plant species of the family Ephedraceae, order Ephedrales, class Gnetopsida, division Gnetophyta. It is a source of EPHEDRINE and other alkaloids.
Venoms produced by frogs, toads, salamanders, etc. The venom glands are usually on the skin of the back and contain cardiotoxic glycosides, cholinolytics, and a number of other bioactive materials, many of which have been characterized. The venoms have been used as arrow poisons and include bufogenin, bufotoxin, bufagin, bufotalin, histrionicotoxins, and pumiliotoxin.
The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.
Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS.
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
Indolizines are organic compounds that consist of a condensed pyridine and pyrrole ring structure, which can be found in certain natural and synthetic substances, and have been studied for their potential biological activities.
Quinolizines are heterocyclic organic compounds containing a bicyclic structure formed by a benzene ring fused to a piperidine ring, which have been used as building blocks in the synthesis of various pharmaceuticals and bioactive molecules.
A plant species of the genus ATROPA, family SOLANACEAE that contains ATROPINE; SCOPOLAMINE; BELLADONNA ALKALOIDS and other SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for SOLANUM.
A plant genus of the family LOGANIACEAE (classified by some botanists as Strychnaceae).
A plant genus of the family RANUNCULACEAE. Members contain isoquinoline alkaloids and triterpene glycosides.
A naturally occurring opium alkaloid that is a centrally acting antitussive agent.
A plant genus of the family APOCYNACEAE. Members contain echitovenidine, echitamine, venenatine (an indole alkaloid), and anti-inflammatory triterpenoids
A plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.
A plant genus of the family LILIACEAE with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. It is the main ingredient of Boicil.
A plant genus of the family APOCYNACEAE that contains bisindole alkaloids and IBOGAINE.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.
An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.
A plant genus of the family RUTACEAE which is used in Chinese medicine (DRUGS, CHINESE HERBAL). Evodiamine and other quinazoline alkaloids (QUINAZOLINES) are obtained from the fruit of E. ruticarpa.
A class of organic compounds containing three ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic
A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.
A genus of leguminous shrubs or trees, mainly tropical, yielding useful compounds such as ALKALOIDS and PLANT LECTINS.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A plant genus of the family ZYGOPHYLLACEAE. Harmala and other ALKALOIDS, phenylpropanoids, and TRITERPENES have been found in plants of this genus.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
A plant genus of the family FABACEAE that contains crotalarin.
Phenanthridines are a class of heterocyclic aromatic organic compounds consisting of two benzene rings fused to a pyridine ring, which have been extensively studied for their biological activities, including antimalarial, antibacterial, and antitumor properties.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
A plant family of the order Linales, subclass Rosidae, class Magnoliopsida best known for the coca plant.
A plant genus of the family POACEAE. The common name of fescue is also used with some other grasses.
N-methyl-8-azabicyclo[3.2.1]octanes best known for the ones found in PLANTS.
A plant genus of the family ASCLEPIADACEAE. Members contain phenanthro-indolizidine alkaloids.
An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
A plant genus of the family LYCOPODIACEAE. Members contain huperzine, one of the CHOLINESTERASE INHIBITORS.
A plant genus of the family MENISPERMACEAE. Members contain eletefine (a stephaoxocane alkaloid) and tropoloisoquinoline and protoberberine ALKALOIDS.
Use of plants or herbs to treat diseases or to alleviate pain.
A plant genus in the family PAPAVERACEAE, order Papaverales, subclass Magnoliidae.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
A plant genus of the family FABACEAE.
A piperidine botanical insecticide.
Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. Many of them are naturally occurring alkaloids.
A mitosporic fungal genus with many reported ascomycetous teleomorphs. Cephalosporin antibiotics are derived from this genus.
Enzymes that catalyze the cleavage of a carbon-nitrogen bond by means other than hydrolysis or oxidation. Subclasses are the AMMONIA-LYASES, the AMIDINE-LYASES, the amine-lyases, and other carbon-nitrogen lyases. EC 4.3.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
A plant genus of the family LOGANIACEAE (classified by some botanists as Gelsemiaceae). The sometimes used common name of trumpet flower is also used for DATURA.
The geographic designation for states bordering on or located in the Pacific Ocean. The states so designated are Alaska, California, Hawaii, Oregon, and Washington. (U.S. Geologic Survey telephone communication)
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
The above-ground plant without the roots.
Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.
An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed)
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
A plant genus of the family LILIACEAE. Members contain radiatine, vittatine, haemanthamine, lycorenine, dihydrolycorine, lycorine, lycoricidinol and lycoricidine.
A plant genus of the family LAURACEAE. Members contain cryptofolione, caryachine, grandisin and other compounds. Some PEUMUS species have been reclassified as CRYPTOCARYA.
A plant genus of the family RANUNCULACEAE. Members contain BERBERINE.
The characteristic three-dimensional shape of a molecule.
A plant genus of the family RUBIACEAE, order Rubiales, subclass Asteridae. Cephaelis ipecacuanha is the source of IPECAC.
A plant family of the order Solanales, subclass Asteridae. Among the most important are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.
The parts of plants, including SEEDS.
A plant genus of the family FABACEAE. Members contain SWAINSONINE.
A genus of large, brightly colored SPONGES in the family Agelasidae, possessing a skeleton of spongin fibers with a core of large spicules (megascleres).
A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A plant genus of the family LILIACEAE that contains ALKALOIDS.
Common member of the Gramineae family used as cattle FODDER. It harbors several fungi and other parasites toxic to livestock and people and produces allergenic compounds, especially in its pollen. The most commonly seen varieties are L. perenne, L. multiflorum, and L. rigidum.
A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).
Phenanthrenes are aromatic hydrocarbons consisting of three benzene rings fused together in a linear arrangement, commonly found in various plants and some animals, and can act as precursors for certain steroid hormones or exhibit pharmacological activities with potential therapeutic uses.
A plant genus of the family NELUMBONACEAE. The common name of lotus is also for LOTUS and NYMPHAEA.
A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.
A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.
A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.
Cyclic hydrocarbons that contain multiple rings and share one or more atoms.
The buttercup plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
A plant species of the genus PINUS that contains isocupressic acid.
A drug that is derived from opium, which contains from 0.3-1.5% thebaine depending on its origin. It produces strychnine-like convulsions rather than narcosis. It may be habit-forming and is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). (From Merck Index, 11th ed)
Plants or plant parts which are harmful to man or other animals.
An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
A plant genus of the genus STRYCHNOS, family LOGANIACEAE that is the source of STRYCHNINE.
A subclass of iridoid compounds that include a glucoside moiety, usually found at the C-1 position.
A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.
Members of the group of vascular plants which bear flowers. They are differentiated from GYMNOSPERMS by their production of seeds within a closed chamber (OVARY, PLANT). The Angiosperms division is composed of two classes, the monocotyledons (Liliopsida) and dicotyledons (Magnoliopsida). Angiosperms represent approximately 80% of all known living plants.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
A plant genus of the family PAPAVERACEAE that contains benzo[c]phenanthridine alkaloids.
An endosymbiont that is either a bacterium or fungus living part of its life in a plant. Endophytes can benefit host plants by preventing pathogenic organisms from colonizing them.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
The third stomach of ruminants, situated on the right side of the abdomen at a higher level than the fourth stomach and between this latter and the second stomach, with both of which it communicates. From its inner surface project large numbers of leaves or folia, each of which possesses roughened surfaces. In the center of each folium is a band of muscle fibers which produces a rasping movement of the leaf when it contracts. One leaf rubs against those on either side of it, and large particles of food material are ground down between the rough surfaces, preparatory to further digestion in the succeeding parts of the alimentary canal. (Black's Veterinary Dictionary, 17th ed)
Quinolines are heterocyclic aromatic organic compounds consisting of a two-nitrogened benzene ring fused to a pyridine ring, which have been synthesized and used as building blocks for various medicinal drugs, particularly antibiotics and antimalarials.
A genus of rubiaceous South American trees that yields the toxic CINCHONA ALKALOIDS from their bark; QUININE; QUINIDINE; chinconine, cinchonidine and others are used to treat MALARIA and CARDIAC ARRHYTHMIAS.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
A plant genus of the family RUTACEAE that is the natural source of PILOCARPINE.
The study of the origin, structure, development, growth, function, genetics, and reproduction of organisms which inhabit the OCEANS AND SEAS.
A plant genus of the family SAPINDACEAE. The seed of P. cupana is the source of guarana powder which contains 4% CAFFEINE.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype. (1/3151)

Epibatidine, a neurotoxin isolated from the skin of Epipedobates tricolor, is an efficacious antinociceptive agent with a potency 200 times that of morphine. The toxicity of epibatidine, because of its nonspecificity for both peripheral and central nicotinic receptors, precludes its development as an analgesic. During the synthesis of epibatidine analogs we developed potent antinociceptive agents, typified by CMI-936 and CMI-1145, whose antinociception, unlike that of epibatidine, is mediated via muscarinic receptors. Subsequently, we used specific muscarinic toxins and antagonists to delineate the muscarinic receptor subtype involved in the antinociception evoked by these agents. Thus, the antinociception produced by CMI-936 and CMI-1145 is inhibited substantially by 1) intrathecal injection of the specific muscarinic M4 toxin, muscarinic toxin-3; 2) intrathecally administered pertussis toxin, which inhibits the G proteins coupled to M2 and M4 receptors; and 3) s.c. injection of the M2/M4 muscarinic antagonist himbacine. These results demonstrate that the antinociception elicited by these epibatidine analogs is mediated via muscarinic M4 receptors located in the spinal cord. Compounds that specifically target the M4 receptor therefore may be of substantial value as alternative analgesics to the opiates.  (+info)

Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor. (2/3151)

The mechanism by which growth factors exert an anti-apoptotic function on many cell types is not well understood. This issue is addressed in relation to epidermal growth factor (EGF) which inhibits apoptosis induced by staurosporine or wortmannin in an epithelial tumour cell line (CNE-2). The presence of EGF substantially reduced the in vitro Ac-DEVD-AMC hydrolytic activity and almost completely suppressed the intracellular cleavage of poly(ADP-ribose) polymerase in staurosporine- or wortmannin-treated cells. Staurosporine but not wortmannin caused the intracellular proteolytic processing of pro-caspase-3 and this event was transiently inhibited by EGF. Staurosporine-induced apoptosis was not inhibited by EGF in the presence of wortmannin or LY294002. Similarly, EGF failed to inhibit wortmannin-induced apoptosis in the presence of staurosporine, chelerythrine chloride or Go6850. These results suggest that phosphatidylinositol 3-kinase and protein kinase C play a role in the survival function of EGF but the reduction of cellular caspase activity cannot be satisfactorily explained by a lack of pro-caspase-3 activation.  (+info)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (3/3151)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. (4/3151)

Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and repair. In human cells treated with the topoisomerase inhibitors camptothecin or etoposide (VP-16), we find that RPA2, the middle-sized subunit of RPA, becomes rapidly phosphorylated. This response appears to be due to DNA-dependent protein kinase (DNA-PK) and to be independent of p53 or the ataxia telangiectasia mutated (ATM) protein. RPA2 phosphorylation in response to camptothecin required ongoing DNA replication. Camptothecin itself partially inhibited DNA synthesis, and this inhibition followed the same kinetics as DNA-PK activation and RPA2 phosphorylation. DNA-PK activation and RPA2 phosphorylation were prevented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentiates camptothecin cytotoxicity. The DNA-PK catalytic subunit (DNA-PKcs) was found to bind RPA which was replaced by the Ku autoantigen upon camptothecin treatment. DNA-PKcs interacted directly with RPA1 in vitro. We propose that the encounter of a replication fork with a topoisomerase-DNA cleavage complex could lead to a juxtaposition of replication fork-associated RPA and DNA double-strand end-associated DNA-PK, leading to RPA2 phosphorylation which may signal the presence of DNA damage to an S-phase checkpoint mechanism. KEYWORDS: camptothecin/DNA damage/DNA-dependent protein kinase/RPA2 phosphorylation  (+info)

Effects of prostaglandin F2 alpha on intracellular pH, intracellular calcium, cell shortening and L-type calcium currents in rat myocytes. (5/3151)

OBJECTIVE: We have studied the mechanisms underlying the positive inotropic action of prostaglandin F2 alpha (PGF2 alpha) by monitoring intracellular calcium transients, intracellular pH, L-type calcium currents and cell shortening in isolated ventricular myocytes. METHODS: Rat myocytes were loaded with fura-2AM for intracellular calcium measurements, or BCECF-AM for pH measurements. Cell shortening was recorded using an edge detection system, and L-type calcium currents measured using whole cell patch clamping. RESULTS: PGF2 alpha (3 nmol l-1-3 mumol l-1 increased single myocyte shortening and reduced resting cell length in a concentration-dependent manner. While myocyte shortening was increased by PGF2 alpha, this was not associated with any change in the amplitude of intracellular calcium transients, diastolic calcium, or L-type calcium currents. However, the same myocytes were capable of responding to catecholamines with increases in calcium transient amplitude and L-type calcium currents. PGF2 alpha (3 mumol l-1 caused a reversible rise in intracellular pH of 0.08 +/- 0.01 pH units (n = 5, p < 0.05). The Na(+)-H+ exchanger inhibitor, HOE 694 (10 mumol l-1, abolished the PGF2 alpha-induced rise in pH and the increase in cell shortening. PGF2 alpha-induced increases in cell shortening and intracellular pH were also attenuated by the protein kinase C (PKC) inhibitor, chelerythrine (2 mumol l-1. CONCLUSION: The positive inotropic action of PGF2 alpha appears to be mediated via activation of the Na(+)-H+ exchanger with the possible involvement of PKC. This suggests that PGF2 alpha-produces intracellular alkalosis, which then sensitizes cardiac myofilaments to calcium.  (+info)

Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction. (6/3151)

Previous results from our laboratory have suggested that morphine can attenuate neutrophil activation in patients with acute myocardial infarction. To elucidate if morphine preconditioning (PC) has the same effects via activation of neutrophil endopeptidase 24.11 (NEP), we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), gp100MEL14 and NEP in adult Wistar rats subjected to ten different protocols (n = 10 for each) at baseline, immediately after and 2 h after morphine PC. All groups were subjected to 30 min of occlusion and 2 h of reperfusion. Similarly, morphine-induced PC was elicited by 3-min drug infusions (100 micrograms/kg) interspersed with 5-min drug-free periods before the prolonged 30-min occlusion. Infarct size (IS), as a percentage of the area at risk (AAR), was determined by triphenyltetrazolium staining. Pretreatment with morphine increased NEP activities (9.86 +/- 1.98 vs. 5.12 +/- 1.10 nmol/mg protein in control group; p < 0.001). Naloxone (mu-opioid receptor antagonist) (4.82 +/- 1.02 nmol/mg protein) and phosphoramidon (NEP inhibitor) (4.66 +/- 1.00 nmol/mg protein) inhibited morphine-activated NEP, whereas glibenclamide (ATP-sensitive potassium channel antagonist) and chelerythrine (protein kinase C inhibitor) had no effects. The ICAM-1 and gp100MEL14 of the third sampling were lowest for those with morphine PC (280 +/- 30 ng/ml and 2.2 +/- 0.7 micrograms/ml; p < 0.001), but naloxone (372 +/- 38 ng/ml and 3.8 +/- 0.9 micrograms/ml) and phosphoramidon (382 +/- 40 ng/ml and 4.2 +/- 1.1 micrograms/ml) abolished the above phenomenon. IS/AAR were definitely lowest for those with morphine PC (24 +/- 7%; p < 0.05). Morphine preconditioning increases NEP activities to attenuate shedding of gp100MEL14 and to ICAM-1 and, thus, provides myocardial protection.  (+info)

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans. (7/3151)

The large species difference in the pharmacokinetics/pharmacodynamics of 7-hydroxystaurosporine (UCN-01) can be partially explained by the high affinity binding of UCN-01 to human alpha1-acid glycoprotein (AGP) (Fuse et al, Cancer Res., 58: 3248-3253, 1998). To confirm whether its binding to human AGP actually changes the in vivo pharmacokinetics, we have studied the alteration in its pharmacokinetics after simultaneous administration of human AGP to rats: (a) the protein binding of UCN-01 was evaluated by chasing its dissociation from proteins using dextran-coated charcoal. The UCN-01 remaining 0.1 h after adding dextran-coated charcoal to human plasma or AGP was approximately 80%, although the values for other specimens, except monkey plasma (approximately 20%), were <1%, indicating that the dissociation from human AGP was specifically slower than from other proteins; and (b) the pharmacokinetics of UCN-01 simultaneously administered with human AGP has been determined. The plasma concentrations after i.v. administration of UCN-O1 with equimolar human AGP were much higher than those after administration of UCN-01 alone. The steady-state distribution volume and the systemic clearance were reduced to about 1/100 and 1/200, respectively. Human AGP thus reduced the distribution and elimination of UCN-01 substantially. On the other hand, dog AGP, which has a low binding affinity for UCN-01, did not change the pharmacokinetics of UCN-01 so much. Furthermore, human AGP markedly reduced the hepatic extraction ratio of UCN-01 from 0.510 to 0.0326. Also, human AGP (10 microM) completely inhibited the initial uptake of UCN-01 (1 microM) into isolated rat hepatocytes, whereas the uptake of UCN-01 was unchanged in the presence of human serum albumin (10 microM). In conclusion, the high degree of binding of UCN-01 to human AGP causes a reduction in the distribution and clearance, resulting in high plasma concentrations in humans.  (+info)

Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. (8/3151)

AIM: To compare the effects of huperzine A (Hup A), tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro. METHODS: The isolated mouse phrenic nerve-hemidiaphragm preparations were used with the conventional intracellular recording technique. The miniature end-plate potentials (MEPP), the mean quantal content of end-plate potentials (EPP), and the resting membrane potentials of muscle fiber were recorded. RESULTS: Hup A, tacrine, and E2020 at the concentration of 1.0 mumol.L-1 increased the amplitude, time-to-peak, and half-decay time of MEPP in the potencies of E2020 > Hup A > tacrine. Hup A did not significantly change the frequency of MEPP, the appearance of giant MEPP or slow MEPP, the resting membrane potentials, and the mean quantal content of EPP. CONCLUSION: Hup A is a selective and potent cholinesterase inhibitor, by which activity it facilitates the cholinergic transmission at mouse neuromuscular junction, and devoid of pre- and post-synaptic actions.  (+info)

Alkaloids are a type of naturally occurring organic compounds that contain mostly basic nitrogen atoms. They are often found in plants, and are known for their complex ring structures and diverse pharmacological activities. Many alkaloids have been used in medicine for their analgesic, anti-inflammatory, and therapeutic properties. Examples of alkaloids include morphine, quinine, nicotine, and caffeine.

Ergot alkaloids are a type of chemical compound that is produced naturally by certain fungi belonging to the genus Claviceps. These alkaloids are most famously known for being produced by the ergot fungus (Claviceps purpurea), which infects cereal grains such as rye and causes a condition known as ergotism in humans and animals that consume the contaminated grain.

Ergot alkaloids have a complex chemical structure and can have various effects on the human body. They are known to act as powerful vasoconstrictors, which means that they cause blood vessels to narrow and can increase blood pressure. Some ergot alkaloids also have psychoactive effects and have been used in the past for their hallucinogenic properties.

In modern medicine, certain ergot alkaloids are used in the treatment of various conditions, including migraines and Parkinson's disease. However, these compounds can be highly toxic if not used properly, and their use must be carefully monitored to avoid serious side effects.

Indole alkaloids are a type of naturally occurring organic compound that contain an indole structural unit, which is a heterocyclic aromatic ring system consisting of a benzene ring fused to a pyrrole ring. These compounds are produced by various plants and animals as secondary metabolites, and they have diverse biological activities. Some indole alkaloids have important pharmacological properties and are used in medicine as drugs or lead compounds for drug discovery. Examples of medically relevant indole alkaloids include reserpine, which is used to treat hypertension, and vinblastine and vincristine, which are used to treat various types of cancer.

Pyrrolizidine alkaloids (PAs) are a group of naturally occurring chemical compounds found in various plants, particularly in the families Boraginaceae, Asteraceae, and Fabaceae. These compounds have a pyrrolizidine ring structure and can be toxic or carcinogenic to humans and animals. They can contaminate food and feed sources, leading to poisoning and health issues. Chronic exposure to PAs has been linked to liver damage, veno-occlusive disease, and cancer. It is important to avoid consumption of plants containing high levels of PAs and to monitor food and feed sources for PA contamination.

Vinca alkaloids are a group of naturally occurring chemicals derived from the Madagascar periwinkle plant, Catharanthus roseus. They are known for their antineoplastic (cancer-fighting) properties and are used in chemotherapy to treat various types of cancer. Some examples of vinca alkaloids include vinblastine, vincristine, and vinorelbine. These agents work by disrupting the normal function of microtubules, which are important components of the cell's structure and play a critical role in cell division. By binding to tubulin, a protein that makes up microtubules, vinca alkaloids prevent the formation of mitotic spindles, which are necessary for cell division. This leads to cell cycle arrest and apoptosis (programmed cell death) in cancer cells. However, vinca alkaloids can also affect normal cells, leading to side effects such as neurotoxicity, myelosuppression, and gastrointestinal disturbances.

Cinchona alkaloids are a group of naturally occurring chemical compounds that are found in the bark of Cinchona trees, which are native to South America. These alkaloids have been used for centuries in traditional medicine to treat various ailments, most notably malaria. The main cinchona alkaloids include quinine, quinidine, cinchonine, and cinchonidine.

Quinine is the most well-known of these alkaloids and has been used for centuries as an effective antimalarial agent. It works by interfering with the reproduction of the malaria parasite in the red blood cells. Quinine is also used to treat other medical conditions, such as leg cramps and restless legs syndrome.

Quinidine is another important cinchona alkaloid that is used primarily as an antiarrhythmic agent to treat irregular heart rhythms. It works by slowing down the electrical conduction in the heart and stabilizing its rhythm.

Cinchonine and cinchonidine have more limited medical uses, mainly as bitter-tasting ingredients in tonics and other beverages. However, they also have some medicinal properties, such as being used as antimalarial agents and antiarrhythmic drugs in some countries.

It is important to note that cinchona alkaloids can have serious side effects if not used properly, so they should only be taken under the supervision of a healthcare professional.

Berberine alkaloids are a type of natural compound found in several plants, including the Berberis species (such as barberry and tree turmeric), goldenseal, Oregon grape, and phellodendron. The most well-known and researched berberine alkaloid is berberine itself, which has a yellow color and is commonly used in traditional medicine for various purposes, such as treating diarrhea, reducing inflammation, and combating bacterial and fungal infections.

Berberine alkaloids have a complex chemical structure that includes a nitrogen atom, making them basic in nature. They are known to interact with several biological targets, including enzymes and receptors, which contributes to their diverse pharmacological activities. Some of the key mechanisms of action of berberine alkaloids include:

1. Inhibition of DNA gyrase: Berberine alkaloids can interfere with bacterial DNA replication by inhibiting the activity of DNA gyrase, an enzyme that helps to unwind and supercoil DNA during replication. This makes them effective against a wide range of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
2. Interaction with cell membranes: Berberine alkaloids can interact with the lipid bilayer of cell membranes, disrupting their integrity and increasing permeability. This can lead to the death of bacteria, fungi, and cancer cells.
3. Modulation of gene expression: Berberine has been shown to regulate the expression of various genes involved in metabolic processes, inflammation, and cell growth. For example, it can activate AMP-activated protein kinase (AMPK), a key enzyme that regulates energy metabolism, which may contribute to its potential benefits in treating diabetes, obesity, and nonalcoholic fatty liver disease.
4. Inhibition of inflammatory mediators: Berberine alkaloids can inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which are involved in the development of various inflammatory diseases.
5. Antioxidant activity: Berberine alkaloids have antioxidant properties, which can help protect cells from damage caused by reactive oxygen species (ROS). This may contribute to their potential benefits in treating neurodegenerative disorders and cancer.

In summary, berberine alkaloids exhibit a wide range of pharmacological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, and metabolic regulatory effects. These properties make them promising candidates for the development of new therapeutic agents to treat various diseases, such as infections, inflammation, diabetes, obesity, and cancer. However, further research is needed to fully understand their mechanisms of action and potential side effects before they can be safely and effectively used in clinical settings.

Amaryllidaceae alkaloids are a type of naturally occurring chemical compounds that are found in plants belonging to the Amaryllidaceae family, which includes amaryllis, snowdrop, and daffodil species. These alkaloids have diverse pharmacological activities and have been studied for their potential medicinal properties. Some well-known Amaryllidaceae alkaloids include lycorine, galanthamine, and haemantamine.

Lycorine has been shown to have antiviral, antimalarial, and anti-cancer properties. Galanthamine is a reversible acetylcholinesterase inhibitor that has been used in the treatment of Alzheimer's disease. Haemantamine has been studied for its potential as an anti-arrhythmic agent.

It is important to note that while Amaryllidaceae alkaloids have shown promise in preclinical studies, further research is needed to determine their safety and efficacy in humans before they can be approved for medical use. Additionally, some of these alkaloids can be toxic in high concentrations, so it is important to exercise caution when handling or consuming plants that contain them.

Aconitum, also known as monkshood or wolf's bane, is a genus of extremely poisonous plants belonging to the family Ranunculaceae. These plants are native to the mountainous regions of the Northern Hemisphere, especially in Asia. The name Aconitum comes from the Greek word "akonitos," which is believed to be derived from "akone," meaning "dart" or "pointed stake," referring to the shape of the plant's roots and its use as a poison on weapons.

The plants contain various alkaloids, primarily aconitine, which is responsible for their toxicity. All parts of the plant are considered poisonous, but the roots and seeds contain the highest concentration of aconitine. Ingesting or touching any part of the Aconitum plant can cause severe symptoms, including nausea, vomiting, diarrhea, heart problems, paralysis, and even death if not treated promptly.

In traditional medicine, some species of Aconitum have been used in small, controlled doses to treat various ailments, such as pain, inflammation, and heart conditions. However, due to the high risk of toxicity, these uses are generally discouraged in modern medicine, and safer alternatives are recommended.

Aporphine is a type of chemical compound called alkaloids, which are found in certain plants. Aporphines have a specific chemical structure and can have various pharmacological effects. They have been studied for their potential medicinal properties, including anti-inflammatory, antispasmodic, and antiasthmatic activities. Some aporphine alkaloids have also been found to have psychoactive effects and are used in traditional medicine in some cultures. However, more research is needed to fully understand the therapeutic potential and safety of aporphines.

'Claviceps' is a genus of filamentous fungi that are commonly known as ergots. These fungi infect the grasses and grains in the family Poaceae, which includes important crop plants such as wheat, rye, barley, and corn. The most well-known species in this genus is Claviceps purpurea, which causes a disease called ergotism in humans and animals that consume contaminated grains.

Ergotism is a serious condition that can cause a range of symptoms, including convulsions, hallucinations, gangrene, and death. The fungus produces alkaloids that can affect the nervous system and blood vessels, leading to these symptoms. Historically, ergotism was a significant public health problem in Europe, where it was known as "St. Anthony's Fire" because of the burning sensations it caused in the limbs.

Today, ergotism is rare thanks to improved grain storage and monitoring practices. However, Claviceps species continue to be important in agriculture and medicine. Some of the alkaloids produced by these fungi have been used in pharmaceuticals to treat conditions such as migraines and Parkinson's disease.

'Catharanthus' is a genus of plants in the Apocynaceae family, commonly known as the dogbane family. The most well-known species is Catharanthus roseus, also known as Madagascar periwinkle or rosy periwinkle. This plant contains alkaloids that have been used in the production of drugs for cancer treatment. Vincristine and vinblastine are two such alkaloids derived from C. roseus, which have shown significant anti-cancer properties and are used to treat various types of cancers, including leukemia and lymphoma.

It is important to note that the use of Catharanthus or its derivatives should be under medical supervision due to their potent biological activities and potential side effects.

Benzylisoquinolines are a type of naturally occurring organic compounds found in various plants. These compounds are derived from the combination of a benzyl group and an isoquinoline ring, hence the name "benzylisoquinolines." They are known to have diverse biological activities, including anti-inflammatory, antispasmodic, and antimicrobial properties. Some well-known examples of benzylisoquinoline alkaloids include papaverine, found in the opium poppy, and berberine, found in various medicinal plants such as goldenseal and barberry. These compounds have been used in traditional medicine for centuries and continue to be studied for their potential therapeutic uses.

Delphinium is a genus of perennial flowering plants in the family Ranunculaceae, also known as larkspur. It includes over 300 species that are native to the Northern Hemisphere, with the greatest diversity found in the mountainous regions of western North America and southern Europe.

Delphiniums are herbaceous plants that can grow up to several feet tall, depending on the species. They have palmately compound leaves that are divided into several lobes. The flowers are borne in dense spikes or racemes and have five distinct sepals, four of which are often brightly colored and petal-like, while the fifth is small and leaflike. The flowers also have numerous stamens and a single pistil.

Delphiniums are popular ornamental plants due to their showy flowers, which come in a variety of colors including blue, purple, pink, white, and yellow. However, some species contain toxic alkaloids that can be harmful or fatal if ingested by humans or animals. It is important to handle delphiniums with care and keep them out of reach of children and pets.

Solanaceous alkaloids are a type of natural toxin found in plants belonging to the Solanaceae family, also known as the nightshade family. These alkaloids contain nitrogen and are produced by the plant as a defense mechanism against herbivores and other threats. Some common solanaceous alkaloids include nicotine, atropine, scopolamine, and solanine.

Nicotine is found in tobacco plants (Nicotiana tabacum) and is highly addictive. Atropine and scopolamine are found in belladonna (Atropa belladonna), also known as deadly nightshade, and are used in medical settings for their anticholinergic effects, but can be toxic or even fatal if ingested in large quantities. Solanine is found in potatoes, tomatoes, and eggplants, and can cause gastrointestinal symptoms such as nausea, vomiting, and diarrhea if consumed in large amounts.

It's worth noting that the levels of solanaceous alkaloids in commonly consumed plants like potatoes and tomatoes are generally low and not considered harmful to most people. However, some individuals may be more sensitive to these compounds and may experience adverse effects even at low levels.

Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. It has a yellow color and has been used in traditional medicine for various purposes such as treating diarrhea, reducing inflammation, and fighting bacteria.

Berberine has been studied for its potential health benefits, including its ability to lower blood sugar levels, reduce cholesterol and triglycerides, and improve cardiovascular health. It is thought to work by activating AMP-activated protein kinase (AMPK), an enzyme that plays a role in regulating metabolism.

However, more research is needed to fully understand the potential benefits and risks of berberine, and it should not be used as a substitute for medical treatment. As with any supplement, it's important to talk to your doctor before taking berberine or any other herbal remedy.

A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.

"Neotyphodium" is not a medical term, but rather it is a genus of fungi that belongs to the family Clavicipitaceae. These endophytic fungi form mutualistic symbiotic relationships with various grass species, including important forage and turfgrasses. They colonize the interior of grass leaves and stems without causing apparent harm to the host plant, while receiving nutrients in return. Some Neotyphodium species produce alkaloids, which can provide the host grass with resistance to insect pests and certain diseases. However, these alkaloids may have negative effects on livestock that graze on the infected grasses, causing various toxicities or neurological disorders.

Coptis is a genus of flowering plants in the family Ranunculaceae, also known as coptis or goldthread. The name "Coptis" is derived from the Greek word "koptos," which means "cutting" or "engraved," referring to the shape of the root.

In a medical context, Coptis species, particularly Coptis chinensis and Coptis japonica, have been used in traditional Chinese medicine for centuries. The rhizomes (underground stems) of these plants contain various alkaloids, including berberine, which has been studied for its potential medicinal properties.

Berberine has been found to have antimicrobial, anti-inflammatory, and antioxidant effects, among others. It has been used in traditional medicine to treat a variety of conditions, such as gastrointestinal disorders, skin diseases, and infections. However, more research is needed to fully understand the potential benefits and risks of using Coptis or its constituents for medicinal purposes.

It's important to note that while some natural substances like berberine have shown promise in preliminary studies, they should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare provider before starting any new supplement regimen.

Rutaceae is a family of plants in the order Sapindales, also known as the rue or citrus family. It includes aromatic trees and shrubs, with around 150 genera and 2,000 species. Many members of this family are economically important, particularly those in the citrus genus (Citrus spp.), which include oranges, lemons, limes, grapefruits, and other citrus fruits. These plants contain essential oils that are used in perfumes, flavorings, and traditional medicines. Some other notable members of Rutaceae include rue (Ruta graveolens), a medicinal herb with a long history of use in traditional medicine, and Cascarilla bark (Croton eluteria), which is used to make a bitter tonic.

Plant poisoning is a form of poisoning that occurs when someone ingests, inhales, or comes into contact with any part of a plant that contains toxic substances. These toxins can cause a range of symptoms, depending on the type and amount of plant consumed or exposed to, as well as the individual's age, health status, and sensitivity to the toxin.

Symptoms of plant poisoning may include nausea, vomiting, diarrhea, abdominal pain, difficulty breathing, skin rashes, seizures, or in severe cases, even death. Some common plants that can cause poisoning include poison ivy, poison oak, foxglove, oleander, and hemlock, among many others.

If you suspect plant poisoning, it is important to seek medical attention immediately and bring a sample of the plant or information about its identity if possible. This will help healthcare providers diagnose and treat the poisoning more effectively.

Molecular structure, in the context of biochemistry and molecular biology, refers to the arrangement and organization of atoms and chemical bonds within a molecule. It describes the three-dimensional layout of the constituent elements, including their spatial relationships, bond lengths, and angles. Understanding molecular structure is crucial for elucidating the functions and reactivities of biological macromolecules such as proteins, nucleic acids, lipids, and carbohydrates. Various experimental techniques, like X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM), are employed to determine molecular structures at atomic resolution, providing valuable insights into their biological roles and potential therapeutic targets.

Ergotism is a condition that results from the consumption of ergot alkaloids, which are found in ergot fungus that infects grains such as rye. There are two types of ergotism: convulsive and gangrenous. Convulsive ergotism can cause seizures, muscle spasms, vomiting, and mental disturbances. Gangrenous ergotism, on the other hand, can lead to constriction of blood vessels, resulting in dry gangrene of the extremities, which can ultimately require amputation. Ergotism has been known since ancient times and was once a significant public health problem before modern agricultural practices were implemented.

"Lycopodium" is a term that has different meanings in various scientific and medicinal contexts. Medically, it often refers to a homeopathic remedy prepared from the spores of the plant Lycopodium clavatum, also known as club moss. This plant is a type of evergreen shrub native to Europe and some parts of North America. The spores are used in homeopathy due to their alleged healing properties, although there is limited scientific evidence supporting these claims.

It's important to note that the medical use and effectiveness of homeopathic remedies like Lycopodium are still a subject of debate within the medical community, and they should not be used as a substitute for evidence-based medical treatments unless recommended by a licensed healthcare professional.

Ergotamine is a type of ergopeptine alkaloid, derived from the ergot fungus (Claviceps purpurea) that parasitizes certain grains, particularly rye. It is a potent vasoconstrictor and has been used medically to prevent migraines and treat cluster headaches, as well as for other uses such as controlling postpartum hemorrhage and reducing symptoms of orthostatic hypotension.

Ergotamine works by binding to serotonin receptors in the brain and causing vasoconstriction of cranial blood vessels, which can help to relieve migraine headaches. However, it can also cause serious side effects such as nausea, vomiting, muscle pain, numbness or tingling in the extremities, and in rare cases, more severe reactions such as ergotism, a condition characterized by vasoconstriction of peripheral blood vessels leading to gangrene.

Ergotamine is usually taken orally, but can also be administered rectally or by inhalation. It is important to follow the dosage instructions carefully and avoid taking excessive amounts, as this can increase the risk of serious side effects. Ergotamine should not be taken during pregnancy or while breastfeeding, and it may interact with other medications, so it is important to inform your healthcare provider of all medications you are taking before starting ergotamine therapy.

Lysergic acid is not a medical term per se, but it is a key component in the chemical structure of several psychedelic drugs, including LSD (lysergic acid diethylamide). Medically, lysergic acid itself does not have any approved uses. However, I can provide you with a definition of LSD:

LSD (Lysergic Acid Diethylamide) is a potent synthetic hallucinogenic drug, derived from lysergic acid, a compound found in the ergot fungus that grows on grains. LSD is typically consumed orally, often by placing it on absorbent paper, which is then dried and cut into small squares known as "blotters."

LSD is classified as a Schedule I controlled substance in the United States and in many other countries, indicating that it has a high potential for abuse, no currently accepted medical use, and a lack of safety under medical supervision. Its effects on perception, mood, and thought are highly unpredictable and can vary greatly among users and even between experiences had by the same user.

"Papaver" is the genus name for the poppy plant family, which includes several species of plants that are known for their showy flowers and often contain medicinal alkaloids. The most well-known member of this family is probably Papaver somniferum, also known as the opium poppy. This particular species contains a number of pharmacologically active compounds, including morphine, codeine, and papaverine, which have been used in various medical contexts for their analgesic, sedative, and vasodilatory effects. However, it's worth noting that the use of Papaver somniferum and its derivatives is tightly regulated due to their potential for abuse and addiction.

Rubiaceae is not a medical term, but a taxonomic category in botany. It refers to the family of flowering plants that includes more than 13,500 species, distributed across approximately 600 genera. Some well-known members of this family include coffee (Coffea arabica), gardenias (Gardenia jasminoides), and madder (Rubia tinctorum).

In a medical context, certain plants from the Rubiaceae family have been used in traditional medicine for various purposes. For example:

* Coffee (Coffea arabica) beans are used to prepare caffeinated beverages that can help with alertness and concentration.
* Gardenia fruits and flowers have been used in traditional Chinese medicine to treat anxiety, insomnia, and inflammation.
* Madder root (Rubia tinctorum) has been used as a dye and in traditional medicine to treat skin conditions and digestive disorders.

However, it's important to note that the medicinal use of plants from this family should be based on scientific evidence and under the guidance of healthcare professionals, as some of these plants can have side effects or interact with medications.

Ephedra is a genus of plants that contain various alkaloids, including ephedrine and pseudoephedrine. These plants, also known as "joint-fir" or "Mormon tea," have been used in traditional medicine for thousands of years to treat various conditions such as asthma, nasal congestion, and hay fever.

Ephedra has been used as a stimulant to increase energy, alertness, and physical performance. However, the use of ephedra-containing supplements has been linked to serious side effects, including heart attack, stroke, and death, particularly when taken in high doses or combined with other stimulants. As a result, the sale of dietary supplements containing ephedrine alkaloids was banned in the United States in 2004.

It's important to note that while ephedra has been used in traditional medicine, its safety and effectiveness have not been thoroughly studied in clinical trials, and its use is not recommended without medical supervision.

Belladonna alkaloids are a group of toxic substances found in the deadly nightshade plant (Atropa belladonna) and other related plants such as Jimsonweed (Datura stramonium) and Daturawort (Datura metel). These alkaloids include atropine, scopolamine, and hyoscyamine. They have anticholinergic properties, which means they block the action of the neurotransmitter acetylcholine in the nervous system.

These alkaloids are used in medical treatments for conditions such as gastrointestinal disorders, Parkinson's disease, and lung conditions, but they can also have serious side effects, including dry mouth, blurred vision, rapid heartbeat, and confusion. In high doses, belladonna alkaloids can cause delirium, hallucinations, and even death. Therefore, they must be used with caution and under the close supervision of a healthcare professional.

Harmine is defined medically as an alpha-carboline derivative that is present in various plants including the seeds of Peganum harmala and the bark of Banisteriopsis caapi. It functions as an monoamine oxidase inhibitor (MAOI) and has been used in traditional medicine for its psychoactive properties. It has also been studied for potential anti-cancer, anti-inflammatory, and neuroprotective effects.

"Aspidosperma" is a genus of flowering plants in the family Apocynaceae, which are native to the Americas. These trees and shrubs are known for their milky sap and contain various alkaloids with potential medicinal properties. However, it's important to note that many of these compounds can also be toxic if not used properly. Therefore, "Aspidosperma" itself is not a medical term or treatment, but rather a botanical name for a group of plants. Any medicinal use of these plants should be done under the guidance of a qualified healthcare professional.

Papaveraceae is a family of flowering plants, also known as the poppy family. It includes annuals, biennials, and perennials with showy flowers and often milky sap. The family contains around 770 species in 42 genera, including some well-known plants such as opium poppy (Papaver somniferum), corn poppy (Papaver rhoeas), and Iceland poppy (Papaver nudicaule). The plants in this family have simple or compound leaves, and their flowers usually have four or six petals. Some members of Papaveraceae are cultivated for their ornamental value, while others produce valuable medicinal compounds such as opium alkaloids.

Stereoisomerism is a type of isomerism (structural arrangement of atoms) in which molecules have the same molecular formula and sequence of bonded atoms, but differ in the three-dimensional orientation of their atoms in space. This occurs when the molecule contains asymmetric carbon atoms or other rigid structures that prevent free rotation, leading to distinct spatial arrangements of groups of atoms around a central point. Stereoisomers can have different chemical and physical properties, such as optical activity, boiling points, and reactivities, due to differences in their shape and the way they interact with other molecules.

There are two main types of stereoisomerism: enantiomers (mirror-image isomers) and diastereomers (non-mirror-image isomers). Enantiomers are pairs of stereoisomers that are mirror images of each other, but cannot be superimposed on one another. Diastereomers, on the other hand, are non-mirror-image stereoisomers that have different physical and chemical properties.

Stereoisomerism is an important concept in chemistry and biology, as it can affect the biological activity of molecules, such as drugs and natural products. For example, some enantiomers of a drug may be active, while others are inactive or even toxic. Therefore, understanding stereoisomerism is crucial for designing and synthesizing effective and safe drugs.

I'm sorry for any confusion, but "Plant Bark" is not a term with a specific medical definition. In general, the bark refers to the outermost covering of a tree or other plant, which serves as protection and provides a barrier against external threats. It is composed of layers including the inner bark (phloem), which transports nutrients throughout the plant, and the outer bark (periderm), which is made up of dead cells that form a protective layer.

While some plants or plant parts do have medicinal properties and are used in various forms of traditional or alternative medicine, "Plant Bark" by itself does not have any specific medical connotations. If you're referring to a specific type of plant bark with potential medicinal uses, please provide more details so I can give a more accurate response.

Ephedrine is a medication that stimulates the nervous system and is used to treat low blood pressure, asthma, and nasal congestion. It works by narrowing the blood vessels and increasing heart rate, which can help to increase blood pressure and open up the airways in the lungs. Ephedrine may also be used as a bronchodilator to treat COPD (chronic obstructive pulmonary disease).

Ephedrine is available in various forms, including tablets, capsules, and solutions for injection. It is important to follow the instructions of a healthcare provider when taking ephedrine, as it can have side effects such as rapid heart rate, anxiety, headache, and dizziness. Ephedrine should not be used by people with certain medical conditions, such as heart disease, high blood pressure, or narrow-angle glaucoma, and it should not be taken during pregnancy or breastfeeding without consulting a healthcare provider.

In addition to its medical uses, ephedrine has been used as a performance-enhancing drug and is banned by many sports organizations. It can also be found in some over-the-counter cold and allergy medications, although these products are required to carry warnings about the potential for misuse and addiction.

Medicinal plants are defined as those plants that contain naturally occurring chemical compounds which can be used for therapeutic purposes, either directly or indirectly. These plants have been used for centuries in various traditional systems of medicine, such as Ayurveda, Chinese medicine, and Native American medicine, to prevent or treat various health conditions.

Medicinal plants contain a wide variety of bioactive compounds, including alkaloids, flavonoids, tannins, terpenes, and saponins, among others. These compounds have been found to possess various pharmacological properties, such as anti-inflammatory, analgesic, antimicrobial, antioxidant, and anticancer activities.

Medicinal plants can be used in various forms, including whole plant material, extracts, essential oils, and isolated compounds. They can be administered through different routes, such as oral, topical, or respiratory, depending on the desired therapeutic effect.

It is important to note that while medicinal plants have been used safely and effectively for centuries, they should be used with caution and under the guidance of a healthcare professional. Some medicinal plants can interact with prescription medications or have adverse effects if used inappropriately.

Opium is defined as the dried latex obtained from incisions made in the unripe seedpods of the opium poppy (Papaver somniferum). It contains a number of alkaloids, including morphine, codeine, and thebaine. Opium has been used for its pain-relieving, euphoric, and sedative effects since ancient times. However, its use is highly regulated due to the risk of addiction and other serious side effects.

Ergolines are a group of ergot alkaloids that have been widely used in the development of various pharmaceutical drugs. These compounds are known for their ability to bind to and stimulate specific receptors in the brain, particularly dopamine receptors. As a result, they have been explored for their potential therapeutic benefits in the treatment of various neurological and psychiatric conditions, such as Parkinson's disease, migraine, and depression.

However, ergolines can also have significant side effects, including hallucinations, nausea, and changes in blood pressure. In addition, some ergot alkaloids have been associated with a rare but serious condition called ergotism, which is characterized by symptoms such as muscle spasms, vomiting, and gangrene. Therefore, the use of ergolines must be carefully monitored and managed to ensure their safety and effectiveness.

Some specific examples of drugs that contain ergolines include:

* Dihydroergotamine (DHE): used for the treatment of migraine headaches
* Pergolide: used for the treatment of Parkinson's disease
* Cabergoline: used for the treatment of Parkinson's disease and certain types of hormonal disorders

It is important to note that while ergolines have shown promise in some therapeutic areas, they are not without their risks. As with any medication, it is essential to consult with a healthcare provider before using any drug containing ergolines to ensure that it is safe and appropriate for an individual's specific needs.

Annonaceae is a family of flowering plants, also known as custard apple family. It includes several genera and species of tropical trees and shrubs that are native to the Americas, Africa, Asia, and Australia. The plants in this family are characterized by their large, often fragrant flowers and fleshy fruits. Some of the commercially important crops in this family include cherimoya, soursop, custard apple, and pawpaw. Many species of Annonaceae have also been studied for their potential medicinal properties, including the presence of alkaloids with anticancer and anti-malarial activities.

I'm sorry for any confusion, but "Senecio" is not a medical term. It is actually the name of a genus of plants in the family Asteraceae, also known as the daisy or composite family. Some species of Senecio contain pyrrolizidine alkaloids, which can be toxic to livestock and potentially harmful to humans if ingested. However, there is no direct medical relevance of "Senecio" itself in the context of medical definitions.

Heterocyclic compounds with 4 or more rings refer to a class of organic compounds that contain at least four aromatic or non-aromatic rings in their structure, where one or more of the rings contains atoms other than carbon (heteroatoms) such as nitrogen, oxygen, sulfur, or selenium. These compounds are widely found in nature and have significant importance in medicinal chemistry due to their diverse biological activities. Many natural and synthetic drugs, pigments, vitamins, and antibiotics contain heterocyclic structures with four or more rings. The properties of these compounds depend on the size, shape, and nature of the rings, as well as the presence and position of functional groups.

"Uncaria" is a genus of woody vines in the family Rubiaceae, commonly known as "cat's claw." The term does not have a specific medical definition, but certain species of Uncaria are used in traditional medicine and have been investigated for their potential medicinal properties. For example, Uncaria tomentosa and Uncaria guianensis are used in traditional medicine for various purposes, including as an anti-inflammatory, immune system stimulant, and for treating gastrointestinal disorders. However, it is important to note that the scientific evidence supporting these uses is limited, and more research is needed before any firm conclusions can be drawn about their safety and efficacy.

"Rauwolfia" is the name of a genus of plants in the dogbane family (Apocynaceae). It includes several species that have been used in traditional medicine for various purposes. The most well-known species is probably Rauwolfia serpentina, also known as Indian snakeroot or sarpagandha.

Extracts from the roots of Rauwolfia serpentina contain a number of alkaloids with pharmacological activity, including reserpine, which has been used in modern medicine to treat high blood pressure and some psychiatric disorders. However, due to its side effects, it is not commonly used today.

It's important to note that the use of Rauwolfia and its extracts should be done under medical supervision, as they can have significant effects on various body systems, including the heart, blood pressure, and nervous system.

Veratrum alkaloids are a group of steroidal alkaloids found in plants belonging to the genus Veratrum, such as Veratrum album (white hellebore) and Veratrum viride (American false hellebore). These compounds have complex structures and can be divided into several types, including veratrine, jervine, and cevadine. They have various pharmacological effects, such as being anticholinergic, antiarrhythmic, and emetic. Veratrum alkaloids are used in traditional medicine, but they can also be highly toxic if ingested or handled improperly.

Porifera, also known as sponges, is a phylum of multicellular aquatic organisms characterized by having pores in their bodies. These pores allow water to circulate through the body, bringing in food and oxygen while expelling waste products. Sponges do not have true tissues or organs; instead, they are composed of specialized cells that perform specific functions. They are generally sessile (non-mobile) and live attached to rocks, coral reefs, or other underwater structures. Some species can be quite large, while others are microscopic in size. Sponges have a long fossil record dating back over 500 million years and play important roles in marine ecosystems as filter feeders and habitat providers for many other marine organisms.

Hypocreales is an order of fungi in the class Sordariomycetes. This group includes many species that are saprophytic (growing on dead or decaying organic matter) as well as pathogenic, causing various diseases in plants and animals. Some notable members of Hypocreales include the genera Trichoderma, Hypocrea, Nectria, and Fusarium. These fungi are characterized by their perithecial ascomata (sexual fruiting bodies) and often produce colorful, flask-shaped structures called ascostromata. Some species in this order produce toxic compounds known as mycotoxins, which can have harmful effects on humans and animals if ingested or inhaled.

Aconitine is a toxic alkaloid compound that can be found in various plants of the Aconitum genus, also known as monkshood or wolf's bane. It is a highly poisonous substance that can cause serious medical symptoms, including numbness, tingling, and paralysis of the muscles, as well as potentially life-threatening cardiac arrhythmias and seizures. Aconitine works by binding to sodium channels in nerve cells, causing them to become overactive and leading to the release of large amounts of neurotransmitters.

In medical contexts, aconitine is not used as a therapeutic agent due to its high toxicity. However, it has been studied for its potential medicinal properties, such as its analgesic and anti-inflammatory effects. Despite these potential benefits, the risks associated with using aconitine as a medicine far outweigh any possible advantages, and it is not considered a viable treatment option.

Epichloe is a genus of fungi that are commonly found as endophytes (symbiotic fungi living inside plant tissues) in grasses. These fungi can form mutualistic relationships with their host plants, providing them with resistance to various stressors such as drought, pests, and pathogens. Some Epichloe species can also produce alkaloids that are toxic to livestock, which can have both positive and negative effects on the animals that graze on the grasses.

Epichloe fungi typically infect the above-ground tissues of their host plants, such as leaves and stems, and can form visible structures called sclerotia, which are compact masses of fungal tissue that can survive in the soil for extended periods. These sclerotia can serve as a source of infection for new grass hosts, allowing the Epichloe fungi to spread throughout populations of grasses.

Overall, Epichloe fungi play important roles in the ecology and evolution of grassland ecosystems, and have potential applications in agriculture and conservation.

I'm sorry for any confusion, but "Liliaceae" is not a medical term. It is a taxonomic category in botany, specifically it is the family name for plants that include lilies, tulips, and related species. In a medical context, you might be referring to the specific plant species themselves, or possibly the allergic reactions some people can have to the pollen of these plants. If you have any more specific questions about botanical terms in a medical context, I'd be happy to try and help further.

"Mitragyna" is a genus of plants in the coffee family (Rubiaceae). The most well-known species within this genus is "Mitragyna speciosa," also known as kratom. Kratom is a tropical evergreen tree native to Southeast Asia, including countries like Thailand, Malaysia, and Indonesia.

The leaves of the kratom tree contain various alkaloids, with mitragynine being the most abundant. Mitragynine has psychoactive properties and can have stimulant-like effects at low doses and opioid-like pain-relieving effects at higher doses. Kratom is often used as a traditional medicine in Southeast Asia to manage pain, fatigue, and opioid withdrawal symptoms. However, its legal status and safety profile are controversial in many other parts of the world.

Harmane, also known as harmaline, is a naturally occurring psychoactive compound found in several plants, including the seeds of the Syrian rue (Peganum harmala) and the bark of the African pinwheel cactus (Adenium obesum). It is an alkaloid with beta-carboline structure.

In a medical context, harmaline has been studied for its potential effects on the central nervous system. It acts as a reversible monoamine oxidase inhibitor (MAOI), which means it can increase the levels of certain neurotransmitters in the brain by preventing their breakdown. This property has led to some research into its use as a treatment for depression and other neurological disorders, although it is not currently approved for medical use in this capacity due to potential side effects and toxicity concerns.

It's important to note that harmaline can have dangerous interactions with certain medications and foods, particularly those containing tyramine, which can lead to a hypertensive crisis. Therefore, its use should only be under the supervision of a qualified medical professional.

Ibogaine is a naturally occurring psychoactive alkaloid found in the root bark of the African shrub, Tabernanthe iboga. It has been used traditionally in West African spiritual practices and healing rituals for centuries. In the medical field, ibogaine has been explored as an experimental treatment for substance abuse disorders, particularly for opioid addiction, due to its ability to reduce withdrawal symptoms and cravings. However, its use is not widely accepted or approved by regulatory agencies due to safety concerns, including potential cardiac toxicity and psychological adverse effects. Therefore, it's essential to conduct thorough research and consult with medical professionals before considering ibogaine treatment.

Benzophenanthridines are a class of chemical compounds that contain a benzophenanthrene skeleton, which is a polycyclic aromatic hydrocarbon structure made up of three benzene rings fused together. Benzophenanthridine alkaloids are naturally occurring compounds found in plants and have various biological activities, including anti-inflammatory, antimicrobial, and antitumor properties. Some well-known benzophenanthridine alkaloids include sanguinarine, chelerythrine, and berberine. These compounds are known to interact with various biological targets such as enzymes, receptors, and DNA, making them of interest in pharmaceutical research and development.

Corydalis is a genus of herbaceous plants in the family Papaveraceae, also known as the poppy family. The name "Corydalis" comes from the Greek word "korydalinos," which means "crested lark," referring to the shape of the flowers. These plants are native to Asia, Europe, and North America. Some species of Corydalis contain alkaloids, which have been used in traditional medicine for their sedative, analgesic, and anti-spasmodic properties. However, it's important to note that these alkaloids can also be toxic in high doses, so these remedies should only be used under the guidance of a qualified healthcare professional.

Cyclization is a chemical process that involves forming a cyclic structure or ring-shaped molecule from a linear or open-chain compound. In the context of medicinal chemistry and drug design, cyclization reactions are often used to synthesize complex molecules, including drugs, by creating rings or fused ring systems within the molecule's structure.

Cyclization can occur through various mechanisms, such as intramolecular nucleophilic substitution, electrophilic addition, or radical reactions. The resulting cyclized compounds may exhibit different chemical and biological properties compared to their linear precursors, making them valuable targets for drug discovery and development.

In some cases, the cyclization process can lead to the formation of stereocenters within the molecule, which can impact its three-dimensional shape and how it interacts with biological targets. Therefore, controlling the stereochemistry during cyclization reactions is crucial in medicinal chemistry to optimize the desired biological activity.

Overall, cyclization plays a significant role in the design and synthesis of many pharmaceutical compounds, enabling the creation of complex structures that can interact specifically with biological targets for therapeutic purposes.

Ephedra sinica, also known as Ma Huang, is a plant that has been used in traditional Chinese medicine for thousands of years. It contains several alkaloids, including ephedrine and pseudoephedrine, which have stimulant effects on the central nervous system and cardiovascular system.

Ephedra sinica has been used to treat various medical conditions such as asthma, bronchitis, and nasal congestion. However, its use as a dietary supplement or weight loss aid has been controversial due to concerns about its safety. The U.S. Food and Drug Administration (FDA) banned the sale of dietary supplements containing ephedra in 2004 due to the risk of serious adverse effects, including heart attack, stroke, and death.

It is important to note that Ephedra sinica should only be used under the supervision of a qualified healthcare professional, as it can interact with other medications and have potentially dangerous side effects.

Amphibian venoms are toxic secretions produced by certain species of amphibians, such as frogs, toads, and salamanders. These secretions are often produced by specialized glands in the skin and can contain a variety of bioactive compounds, including alkaloids, steroids, peptides, and proteins. Some amphibian venoms can cause painful burns or irritation upon contact with the skin, while others can be deadly if ingested or introduced into the bloodstream through wounds or mucous membranes.

The study of amphibian venoms has gained increasing attention in recent years due to their potential as sources of novel bioactive compounds with therapeutic applications. For example, some peptides found in amphibian venoms have been shown to have potent analgesic, anti-inflammatory, and antimicrobial properties, making them promising candidates for the development of new drugs.

It is important to note that not all amphibians produce venom, and even those that do may use their toxic secretions primarily for defense against predators rather than for hunting prey. Additionally, while some amphibian venoms can be dangerous or even lethal to humans, most cases of envenomation occur in the context of intentional handling or accidental contact with these animals in their natural habitats.

Apocynaceae is a family of flowering plants that includes shrubs, trees, and vines. It's also known as the dogbane or milkweed family. The plants in this family have milky sap and contain toxic compounds, which can be harmful or even fatal to animals and humans if ingested. Some well-known members of Apocynaceae include the various species of milkweeds (Asclepias spp.), oleander (Nerium oleander), and periwinkle (Vinca spp.).

The family is characterized by having opposite leaves, flowers with five petals and five sepals, and a superior ovary. The fruits are usually paired follicles that contain numerous seeds with tufts of hair to aid in wind dispersal. Many species in this family have medicinal or toxic properties, and some have economic importance as ornamental plants, sources of fiber, or for their use in traditional medicine.

Indolizidines are a type of heterocyclic organic compound that contains a five-membered ring fused to a six-membered ring, with one nitrogen atom and one carbon atom common to both rings. The structure of indolizidine is similar to that of the naturally occurring alkaloids, which are found in various plants and animals and have diverse biological activities.

Indolizidines can be synthesized in the laboratory and have been studied for their potential therapeutic uses, such as anti-inflammatory, antiviral, and insecticidal properties. However, they can also have toxic effects and may interact with other drugs or chemicals in the body.

It is important to note that indolizidines are not a medical term per se, but rather a chemical classification of a specific type of organic compound.

Isoquinolines are not a medical term per se, but a chemical classification. They refer to a class of organic compounds that consist of a benzene ring fused to a piperidine ring. This structure is similar to that of quinoline, but with the nitrogen atom located at a different position in the ring.

Isoquinolines have various biological activities and can be found in some natural products, including certain alkaloids. Some isoquinoline derivatives have been developed as drugs for the treatment of various conditions, such as cardiovascular diseases, neurological disorders, and cancer. However, specific medical definitions related to isoquinolines typically refer to the use or effects of these specific drugs rather than the broader class of compounds.

Vinblastine is an alkaloid derived from the Madagascar periwinkle plant (Catharanthus roseus) and is primarily used in cancer chemotherapy. It is classified as a vinca alkaloid, along with vincristine, vinorelbine, and others.

Medically, vinblastine is an antimicrotubule agent that binds to tubulin, a protein involved in the formation of microtubules during cell division. By binding to tubulin, vinblastine prevents the assembly of microtubules, which are essential for mitosis (cell division). This leads to the inhibition of cell division and ultimately results in the death of rapidly dividing cells, such as cancer cells.

Vinblastine is used to treat various types of cancers, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, breast cancer, and others. It is often administered intravenously in a healthcare setting and may be given as part of a combination chemotherapy regimen with other anticancer drugs.

As with any medication, vinblastine can have side effects, including bone marrow suppression (leading to an increased risk of infection, anemia, and bleeding), neurotoxicity (resulting in peripheral neuropathy, constipation, and jaw pain), nausea, vomiting, hair loss, and mouth sores. Regular monitoring by a healthcare professional is necessary during vinblastine treatment to manage side effects and ensure the safe and effective use of this medication.

Diterpenes are a class of naturally occurring compounds that are composed of four isoprene units, which is a type of hydrocarbon. They are synthesized by a wide variety of plants and animals, and are found in many different types of organisms, including fungi, insects, and marine organisms.

Diterpenes have a variety of biological activities and are used in medicine for their therapeutic effects. Some diterpenes have anti-inflammatory, antimicrobial, and antiviral properties, and are used to treat a range of conditions, including respiratory infections, skin disorders, and cancer.

Diterpenes can be further classified into different subgroups based on their chemical structure and biological activity. Some examples of diterpenes include the phytocannabinoids found in cannabis plants, such as THC and CBD, and the paclitaxel, a diterpene found in the bark of the Pacific yew tree that is used to treat cancer.

It's important to note that while some diterpenes have therapeutic potential, others may be toxic or have adverse effects, so it is essential to use them under the guidance and supervision of a healthcare professional.

I'm sorry for any confusion, but "Indolizines" is not a medical term. It is a chemical term that refers to a class of heterocyclic organic compounds which contain a seven-membered ring with two nitrogen atoms and a carbon-carbon double bond. They are used in the synthesis of various pharmaceuticals and natural products, but they are not a medical condition or diagnosis.

Quinolizines are not a medical term, but a chemical classification for a group of compounds that contain a quinolizine ring in their structure. A quinolizine ring is a polycyclic aromatic hydrocarbon with eight pi electrons and consists of two benzene rings fused to a piperidine ring.

Quinolizines have been studied for their potential medicinal properties, including anti-malarial, anti-cancer, and anti-microbial activities. However, there are no currently approved drugs that contain quinolizine as the primary active ingredient. Therefore, it is not possible to provide a medical definition of 'Quinolizines.'

'Atropa belladonna' is a plant species that is commonly known as deadly nightshade. It belongs to the family Solanaceae and is native to Europe, North Africa, and Western Asia. The plant contains powerful toxic alkaloids, including atropine, scopolamine, and hyoscyamine, which can have various pharmacological effects on the human body.

Atropa belladonna has been used in medicine for its anticholinergic properties, which include blocking the action of the neurotransmitter acetylcholine in the nervous system. This effect can be useful in treating conditions such as Parkinson's disease, gastrointestinal disorders, and respiratory problems. However, due to its high toxicity, the use of Atropa belladonna and its alkaloids is closely regulated and requires medical supervision.

It is important to note that all parts of the plant, including the berries and leaves, are highly toxic and can cause serious harm or death if ingested or otherwise introduced to the body. Therefore, it is essential to exercise caution when handling this plant and to seek immediate medical attention if exposure occurs.

"Strychnos" is a genus of plants, specifically belonging to the Loganiaceae family. While not a medical term itself, certain species of Strychnos contain toxic alkaloids that have been used in medicine and are important to understand from a medical and pharmacological perspective.

The most well-known species is Strychnos nux-vomica, which produces the potent alkaloid strychnine. This alkaloid acts as a competitive antagonist at glycine receptors in the central nervous system, leading to uncontrolled muscle contractions, stiffness, and potentially life-threatening convulsions if ingested or otherwise introduced into the body.

Another important alkaloid found in some Strychnos species is brucine, which also has toxic properties, although it is less potent than strychnine. Both of these alkaloids are used in research and have been employed in the past as rodenticides, but their use in medicine is limited due to their high toxicity.

In a medical context, knowing about Strychnos plants and their toxic alkaloids is essential for understanding potential poisonings, recognizing symptoms, and providing appropriate treatment.

I'm sorry for any confusion, but "Thalictrum" is not a medical term. It is the name of a genus of flowering plants in the family Ranunculaceae, also known as meadow rue. These plants are native to temperate regions of the Northern Hemisphere and have diverse ornamental uses due to their showy flowers. If you have any questions about a medical condition or term, I'd be happy to try to help with that instead!

Noscapine is a natural alkaloid compound found in the opium poppy (Papaver somniferum) and some other plants. It has been used medically as a cough suppressant and antitussive agent, acting on the cough center in the brain to reduce the cough reflex. Noscapine is not habit-forming and does not have the same addictive properties as other opium derivatives like morphine or codeine. It also has some anti-inflammatory and mild pain-relieving effects, although it is not typically used for pain management. In addition, noscapine has been studied for its potential anticancer properties, particularly in relation to its ability to inhibit the formation of blood vessels that feed tumors (angiogenesis).

Alstonia is a genus of flowering plants in the dogwood family, Cornaceae. It includes several species of trees and shrubs that are native to tropical regions of the world, particularly Southeast Asia, Australia, and Africa. Some species of Alstonia are known for their medicinal properties and have been used in traditional medicine to treat a variety of ailments, including fever, malaria, and gastrointestinal disorders. The bark and leaves of these plants contain various alkaloids and other compounds that have been found to have pharmacological activity. However, it is important to note that the use of Alstonia species as medicine should be done under the guidance of a qualified healthcare professional, as these plants can also have toxic effects if not used properly.

"Lupinus" is not a medical term. It is the genus name for the group of plants commonly known as lupines or bluebonnets. Some people may use "lupinus" in a medical context to refer to an allergy or sensitivity to lupine beans or other parts of the lupine plant, which can cause symptoms such as rash, itching, and digestive issues. However, this is not a widely recognized medical condition and reactions to lupines are relatively rare. If you have any concerns about a potential allergy or sensitivity to lupines, it is best to consult with a healthcare professional for proper evaluation and treatment.

"Veratrum" is a genus of plants that are part of the Melanthiaceae family, also known as hellebore. These plants contain various alkaloids with pharmacological properties and have been used in traditional medicine for their therapeutic effects. However, they can also be highly toxic if not used properly.

In a medical context, "Veratrum" may refer to the medicinal preparations made from these plants, which have been used historically to treat various conditions such as hypertension, heart failure, and gastrointestinal disorders. However, due to their narrow therapeutic index and potential for serious side effects, they are not commonly used in modern medicine.

It's worth noting that the term "Veratrum" is primarily a botanical designation, and its medical use is relatively limited. If you have any specific questions about the medicinal or toxicological properties of Veratrum plants, it would be best to consult with a healthcare professional or a trained medical herbalist.

"Tabernaemontana" is a genus of evergreen trees and shrubs in the dogbane family, Apocynaceae. It includes around 100 species that are native to tropical regions of the Americas, Africa, and Asia. Some species of Tabernaemontana contain alkaloids, which have been used in traditional medicine for various purposes, such as treating pain, inflammation, and gastrointestinal disorders. However, it is important to note that these compounds can also be toxic if not used properly, so they should only be administered under the guidance of a qualified healthcare professional.

I believe there may be a slight misunderstanding in your question. "Plant leaves" are not a medical term, but rather a general biological term referring to a specific organ found in plants.

Leaves are organs that are typically flat and broad, and they are the primary site of photosynthesis in most plants. They are usually green due to the presence of chlorophyll, which is essential for capturing sunlight and converting it into chemical energy through photosynthesis.

While leaves do not have a direct medical definition, understanding their structure and function can be important in various medical fields, such as pharmacognosy (the study of medicinal plants) or environmental health. For example, certain plant leaves may contain bioactive compounds that have therapeutic potential, while others may produce allergens or toxins that can impact human health.

Poaceae is not a medical term but a taxonomic category, specifically the family name for grasses. In a broader sense, you might be asking for a medical context where knowledge of this plant family could be relevant. For instance, certain members of the Poaceae family can cause allergies or negative reactions in some people.

In a medical definition, Poaceae would be defined as:

The family of monocotyledonous plants that includes grasses, bamboo, and sedges. These plants are characterized by narrow leaves with parallel veins, jointed stems (called "nodes" and "internodes"), and flowers arranged in spikelets. Some members of this family are important food sources for humans and animals, such as rice, wheat, corn, barley, oats, and sorghum. Other members can cause negative reactions, like skin irritation or allergies, due to their silica-based defense structures called phytoliths.

Ergonovine is a medication that belongs to a class of drugs called ergot alkaloids. It is derived from the ergot fungus and is used in medical settings as a uterotonic agent, which means it causes the uterus to contract. Ergonovine is often used after childbirth to help the uterus return to its normal size and reduce bleeding.

Ergonovine works by binding to specific receptors in the smooth muscle of the uterus, causing it to contract. It has a potent effect on the uterus and can also cause vasoconstriction (narrowing of blood vessels) in other parts of the body. This is why ergonovine is sometimes used to treat severe bleeding caused by conditions such as uterine fibroids or ectopic pregnancy.

Like other ergot alkaloids, ergonovine can have serious side effects if not used carefully. It should be administered under the close supervision of a healthcare provider and should not be used in women with certain medical conditions, such as high blood pressure or heart disease. Ergonovine can also interact with other medications, so it's important to inform your healthcare provider of all medications you are taking before receiving this drug.

Evodia is a plant genus that belongs to the family Rutaceae. It is also known as Evodia rutaecarpa, and its fruit is used in traditional Chinese medicine for treating various conditions such as nausea, vomiting, abdominal pain, and diarrhea. The active constituent of Evodia is evodiamine, which has been studied for its potential medicinal properties, including anti-inflammatory, analgesic, and anti-cancer effects. However, more research is needed to confirm these effects and establish the safety and efficacy of Evodia as a medical treatment.

Heterocyclic compounds are organic molecules that contain a ring structure made up of at least one atom that is not carbon, known as a heteroatom. These heteroatoms can include nitrogen, oxygen, sulfur, or other elements. In the case of "3-ring" heterocyclic compounds, the molecule contains three interconnected ring structures, at least one of which includes a heteroatom.

Examples of 3-ring heterocyclic compounds include:

1. Triazoles: These are compounds with two nitrogen atoms and one carbon atom in each of the three rings.
2. Oxadiazoles: These are compounds that contain two nitrogen atoms and one oxygen atom in their three-ring structure.
3. Thiadiazoles: These are compounds containing two nitrogen atoms and one sulfur atom in their three-ring structure.

These 3-ring heterocyclic compounds have significant importance in medicinal chemistry, as they often exhibit unique biological activities and can serve as the basis for drug design and development.

I apologize for any confusion, but "Lauraceae" is not a medical term. It is a taxonomic category in botany, referring to the Laurel family of plants, which includes several genera and species of trees and shrubs. Some well-known members of this family include laurels, cinnamon, bay leaves, and avocados.

If you have any questions related to medical terminology or health sciences, I would be happy to help. Please provide me with the necessary details so I can offer an accurate response.

'Erythrina' is a botanical term, not a medical one. It refers to a genus of plants in the family Fabaceae, also known as the pea or legume family. These plants are commonly called coral trees due to their bright red flowers. While some parts of certain species can have medicinal uses, such as anti-inflammatory and analgesic properties, 'Erythrina' itself is not a medical term or condition.

Antineoplastic agents, phytogenic, also known as plant-derived anticancer drugs, are medications that are derived from plants and used to treat cancer. These agents have natural origins and work by interfering with the growth and multiplication of cancer cells, helping to slow or stop the spread of the disease. Some examples of antineoplastic agents, phytogenic include paclitaxel (Taxol), vincristine, vinblastine, and etoposide. These drugs are often used in combination with other treatments such as surgery, radiation therapy, and other medications to provide a comprehensive approach to cancer care.

"Peganum" is the name of a genus of plants, specifically those in the family Nitrariaceae. The most well-known species in this genus is "Peganum harmala," also known as Syrian rue or esfand. This plant has been used in traditional medicine in various cultures for its psychoactive and hallucinogenic properties, as well as for treating ailments such as rheumatism, skin conditions, and gastrointestinal disorders. However, it can also have toxic effects and should be used with caution. It's important to note that the use of Peganum in medical treatment is not widely accepted or studied in modern Western medicine.

Magnetic Resonance Spectroscopy (MRS) is a non-invasive diagnostic technique that provides information about the biochemical composition of tissues, including their metabolic state. It is often used in conjunction with Magnetic Resonance Imaging (MRI) to analyze various metabolites within body tissues, such as the brain, heart, liver, and muscles.

During MRS, a strong magnetic field, radio waves, and a computer are used to produce detailed images and data about the concentration of specific metabolites in the targeted tissue or organ. This technique can help detect abnormalities related to energy metabolism, neurotransmitter levels, pH balance, and other biochemical processes, which can be useful for diagnosing and monitoring various medical conditions, including cancer, neurological disorders, and metabolic diseases.

There are different types of MRS, such as Proton (^1^H) MRS, Phosphorus-31 (^31^P) MRS, and Carbon-13 (^13^C) MRS, each focusing on specific elements or metabolites within the body. The choice of MRS technique depends on the clinical question being addressed and the type of information needed for diagnosis or monitoring purposes.

Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.

Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.

It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.

'Crotalaria' is a genus of flowering plants in the family Fabaceae, also known as the pea or legume family. These plants are commonly known as rattleboxes due to the seeds that rattle inside their swollen, inflated pods. The plants are native to tropical and warm temperate regions around the world and contain several species that can be found in various environments such as grasslands, savannas, and disturbed areas.

While 'Crotalaria' itself is not a medical term, some species of this plant genus have been reported to contain pyrrolizidine alkaloids (PAs), which can be toxic to humans and animals if ingested. These toxins can cause liver damage and other health issues in severe cases. However, it's important to note that not all Crotalaria species produce PAs, and the toxicity levels may vary depending on the specific species and individual sensitivity.

In summary, 'Crotalaria' is a genus of flowering plants with some species containing potentially toxic pyrrolizidine alkaloids. While it is not a medical term itself, it has implications for human and animal health due to the presence of these toxins in certain species.

Phenanthridines are a class of heterocyclic aromatic organic compounds that consist of a phenanthrene core (a polycyclic aromatic hydrocarbon made up of three benzene rings) fused with a pyridine ring (a six-membered ring containing five carbon atoms and one nitrogen atom). They have the chemical formula C12H9N.

Phenanthridines are important in medicinal chemistry because some of their derivatives exhibit various biological activities, such as antitumor, antibacterial, antifungal, anti-inflammatory, and antiviral properties. Some well-known phenanthridine derivatives include the chemotherapeutic agents amsacrine and doxorubicin, which are used to treat various types of cancer.

It's worth noting that while phenanthridines have important medical applications, they can also be toxic or harmful if not handled properly. Therefore, it's essential to follow proper safety protocols when working with these compounds in a laboratory setting.

A plant root is not a medical term per se, but it is a term from botany, which is the study of plants. However, I can certainly provide a definition for you.

Plant roots are the underground organs of a plant that typically grow downward into the soil. They serve several important functions, including:

1. Anchorage: Roots help to stabilize the plant and keep it upright in the ground.
2. Absorption: Roots absorb water and nutrients from the soil, which are essential for the plant's growth and development.
3. Conduction: Roots conduct water and nutrients up to the above-ground parts of the plant, such as the stem and leaves.
4. Vegetative reproduction: Some plants can reproduce vegetatively through their roots, producing new plants from root fragments or specialized structures called rhizomes or tubers.

Roots are composed of several different tissues, including the epidermis, cortex, endodermis, and vascular tissue. The epidermis is the outermost layer of the root, which secretes a waxy substance called suberin that helps to prevent water loss. The cortex is the middle layer of the root, which contains cells that store carbohydrates and other nutrients. The endodermis is a thin layer of cells that surrounds the vascular tissue and regulates the movement of water and solutes into and out of the root. The vascular tissue consists of xylem and phloem, which transport water and nutrients throughout the plant.

Erythroxylaceae is a family of flowering plants that includes the genus Erythroxylon, which contains the coca plant (E. coca and E. novogranatense). The coca plant is native to western South America and is well-known for containing cocaine alkaloids in its leaves. Cocaine is a powerful stimulant drug that has been used for medical purposes but is also widely abused illegally.

Erythroxylaceae plants are typically small trees or shrubs found in tropical regions of the world, particularly in South America and Africa. The family includes around 200 species, most of which have simple, opposite leaves and small, greenish flowers. Some species of Erythroxylum produce edible fruits that are used locally as food sources.

It's worth noting that while the coca plant is the most famous member of this family due to its association with cocaine, the vast majority of plants in Erythroxylaceae do not contain any significant amounts of psychoactive compounds.

I apologize for any confusion, but "Festuca" is not a medical term. It is actually the genus name for a group of plants commonly known as fescue grasses. These grasses are often used in lawns, pastures, and meadows. If you have any questions about a medical term or concept, I would be happy to help if I can!

Tropane alkaloids are a class of naturally occurring compounds that contain a tropane ring in their chemical structure. This ring is composed of a seven-membered ring with two nitrogen atoms, one of which is part of a piperidine ring. Tropane alkaloids are found in various plants, particularly those in the Solanaceae family, which includes nightshade, belladonna, and datura. Some well-known tropane alkaloids include atropine, scopolamine, and cocaine. These compounds have diverse pharmacological activities, such as anticholinergic, local anesthetic, and central nervous system stimulant effects.

"Tylophora" is a genus of plants in the family Asclepiadaceae, also known as the milkweed family. There are several species within this genus, including Tylophora asthmatica and Tylophora indica, which have been used in traditional medicine to treat various conditions such as asthma, bronchitis, and skin diseases. The active compounds found in these plants include alkaloids and flavonoids, which are believed to have anti-inflammatory and other therapeutic properties. However, it is important to note that the use of Tylophora for medicinal purposes should be done under the guidance of a healthcare professional, as there may be potential risks and interactions with other medications.

Arecoline is a parasympathomimetic alkaloid that is the primary active component found in the areca nut, which is chewed for its psychoactive effects in various parts of the world. It can cause stimulation of the nervous system and has been associated with several health risks, including oral cancer and cardiovascular disease.

The medical definition of Arecoline is:

A parasympathomimetic alkaloid found in the areca nut, which is chewed for its psychoactive effects. It stimulates the nervous system and has been associated with several health risks, including oral cancer and cardiovascular disease. The chemical formula for Arecoline is C7H9NO2.

I apologize for any confusion, but "Stemonaceae" is not a medical term. It is a taxonomic category in botany, specifically a family of flowering plants that are primarily found in tropical regions of the Americas and Asia. The plants in this family are characterized by their unique flowers and often contain alkaloids, which can have various pharmacological properties.

If you have any medical concerns or questions, I would be happy to help if you could provide a more appropriate term or context.

A plant stem is not typically defined in a medical context, but rather in the field of botany. However, I can certainly provide a general biological definition for you.

In plants, stems are organs that serve primarily as support structures, holding leaves, flowers, and fruits aloft where they can receive sunlight and exchange gases. They also act as conduits, transporting water, nutrients, and sugars made during photosynthesis between the roots and shoots of a plant.

The stem is usually composed of three main tissue systems: dermal, vascular, and ground. The dermal tissue system forms the outermost layer(s) of the stem, providing protection and sometimes participating in gas exchange. The vascular tissue system contains the xylem (which transports water and nutrients upward) and phloem (which transports sugars and other organic compounds downward). The ground tissue system, located between the dermal and vascular tissues, is responsible for food storage and support.

While not a direct medical definition, understanding the structure and function of plant stems can be relevant in fields such as nutrition, agriculture, and environmental science, which have implications for human health.

Huperzia is actually not a medical term itself, but it refers to a genus of clubmosses (Huperzia serrata) that are found in Asia. This plant contains a compound called huperzine A, which has been studied for its potential cognitive-enhancing and neuroprotective effects.

Huperzine A is an acetylcholinesterase inhibitor, which means it can increase the levels of the neurotransmitter acetylcholine in the brain by blocking the enzyme that breaks it down. This has led to its investigation as a possible treatment for Alzheimer's disease and other neurological disorders characterized by cognitive decline.

While Huperzia itself is not a medical term, huperzine A has been studied in clinical trials and is available as a dietary supplement in some countries. However, it is important to note that the use of huperzine A as a treatment for any medical condition should be done under the supervision of a healthcare provider, as it can have side effects and interact with other medications.

Cissampelos is a genus of climbing shrubs and vines that belong to the family Menispermaceae. It includes several species that are native to tropical regions of the Americas, Africa, and Asia. Some of these species have been used in traditional medicine for various purposes, such as treating pain, inflammation, fever, and gastrointestinal disorders. However, it is important to note that many of these uses have not been scientifically validated, and some Cissampelos species contain toxic compounds that can cause adverse effects if used improperly. Therefore, it is recommended to consult with a healthcare professional before using any Cissampelos preparations for medicinal purposes.

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

'Chelidonium' is the medical term for a plant also known as greater celandine or tetterwort. The scientific name for this plant is *Chelidonium majus*. It is a member of the poppy family and has been used in traditional medicine for its alleged healing properties, particularly for treating skin conditions, warts, and digestive issues. However, it's essential to note that the use of Chelidonium as a medical treatment is not supported by robust scientific evidence, and it can have potentially harmful side effects if ingested or applied topically in high concentrations. Always consult with a healthcare professional before starting any new treatments or therapies.

Carbolines are a type of chemical compound that contain a carbazole or dibenzopyrrole structure. These compounds have a variety of uses, including as pharmaceuticals and dyes. Some carbolines have been studied for their potential medicinal properties, such as their ability to act as antioxidants or to inhibit the growth of certain types of cells. However, it is important to note that many carbolines are also known to be toxic and can cause harm if ingested or otherwise introduced into the body. As with any chemical compound, it is essential to use caution when handling carbolines and to follow all safety guidelines to minimize the risk of exposure.

Phenylpropanolamine is a decongestant and appetite suppressant that has been used in over-the-counter and prescription medications. It works by narrowing blood vessels in the nose, which can help to relieve nasal congestion. As an appetite suppressant, it is thought to work by affecting certain chemicals in the brain that control appetite.

However, phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke (bleeding in the brain) and other cardiovascular events, particularly in women who are otherwise healthy but have a history of high blood pressure or smoking. As a result, the U.S. Food and Drug Administration (FDA) advised manufacturers to stop selling over-the-counter products containing phenylpropanolamine in 2005.

It is important to note that this substance should only be used under the supervision of a healthcare professional, and individuals should always follow their doctor's instructions carefully when taking any medication.

"Sophora" does not have a specific medical definition, but it is a term that refers to various species of the Sophora plant genus, which belongs to the Fabaceae (legume) family. Some of these plants have been used in traditional medicine in different cultures.

For instance, Sophora flavescens (Ku Shen) has been used in Traditional Chinese Medicine for its anti-inflammatory, antiviral, and antipyretic properties. It contains several alkaloids, such as matrine and oxymatrine, which have demonstrated pharmacological activities.

Another example is Sophora japonica (Japanese pagoda tree), whose seeds, leaves, and bark have been used in traditional Chinese medicine for treating various conditions like diarrhea, insomnia, and skin diseases. Its active compounds include flavonoids, saponins, and alkaloids, which contribute to its medicinal properties.

It is essential to note that the use of Sophora species or their extracts in a medical context should be based on scientific research and under professional medical supervision due to potential side effects and interactions with other medications.

Anabasine is a type of toxic alkaloid that can be found in certain plants, including the leaves of the tobacco plant Nicotiana glauca (also known as tree tobacco). It has a similar structure to nicotine and can have similar physiological effects, such as stimulating the nervous system and increasing heart rate. However, anabasine is generally considered to be more toxic than nicotine.

Anabasine can also be produced synthetically in a laboratory. It has been used in research as a tool for studying the mechanisms of nicotinic acetylcholine receptors, which are important targets for drugs that affect the nervous system.

In terms of medical definitions, anabasine is not a term that is commonly used in clinical medicine. It is more likely to be encountered in the context of research or toxicology.

"Acridones" are a class of chemical compounds that contain a heterocyclic ring structure consisting of a benzene ring fused to a pyrimidine ring. The name "acridone" refers to the parent compound of this class, which is 9-phenylacridine or dibenzo[b,f]pyrimidine-7(8H)-one.

Acridones have been studied for their potential medicinal properties, including their antimicrobial, antiviral, and antitumor activities. However, some acridones have also been found to be toxic or carcinogenic, so their use in medical applications is limited.

In a medical context, "acridones" may refer to a specific class of drugs that are derived from the parent compound and have been investigated for their potential therapeutic uses. It is important to note that each drug or chemical compound should be evaluated on its own merits and in the context of its specific medical use, as generalizations about a entire class of compounds can be misleading.

"Acremonium" is a genus of filamentous fungi that are commonly found in soil, decaying vegetation, and water. Some species of Acremonium can cause infections in humans, particularly in individuals with weakened immune systems. These infections can affect various organs and tissues, including the skin, nails, lungs, and eyes.

The medical definition of "Acremonium" is therefore a type of fungus that can cause a variety of infectious diseases, particularly in immunocompromised individuals. It's important to note that Acremonium infections are relatively rare, but they can be serious and require prompt medical treatment.

Carbon-nitrogen (C-N) lyases are a class of enzymes that catalyze the breakdown of a carbon-nitrogen bond, releasing an ammonia molecule and leaving a double bond. These enzymes play important roles in various biological processes, such as the biosynthesis and degradation of amino acids, nucleotides, and other biomolecules.

C-N lyases are classified based on the type of bond they cleave and the cofactors or prosthetic groups they use to catalyze the reaction. Some examples of C-N lyases include:

1. Alanine racemase: This enzyme catalyzes the conversion of L-alanine to D-alanine, which is an important component of bacterial cell walls.
2. Aspartate transcarbamylase: This enzyme catalyzes the transfer of a carbamoyl group from carbamoyl phosphate to aspartate, forming N-carbamoyl aspartate and inorganic phosphate. It is an important enzyme in the biosynthesis of pyrimidines.
3. Diaminopimelate decarboxylase: This enzyme catalyzes the decarboxylation of meso-diaminopimelate to form L-lysine, which is an essential amino acid for humans.
4. Glutamate decarboxylase: This enzyme catalyzes the decarboxylation of glutamate to form γ-aminobutyric acid (GABA), a neurotransmitter in the brain.
5. Histidine decarboxylase: This enzyme catalyzes the decarboxylation of histidine to form histamine, which is involved in various physiological processes such as immune response and allergic reactions.

C-N lyases are important targets for drug development, particularly in the treatment of bacterial infections and neurological disorders.

"Spiro compounds" are not specifically classified as medical terms, but they are a concept in organic chemistry. However, I can provide a general definition:

Spiro compounds are a type of organic compound that contains two or more rings, which share a single common atom, known as the "spiro center." The name "spiro" comes from the Greek word for "spiral" or "coiled," reflecting the three-dimensional structure of these molecules.

The unique feature of spiro compounds is that they have at least one spiro atom, typically carbon, which is bonded to four other atoms, two of which belong to each ring. This arrangement creates a specific geometry where the rings are positioned at right angles to each other, giving spiro compounds distinctive structural and chemical properties.

While not directly related to medical terminology, understanding spiro compounds can be essential in medicinal chemistry and pharmaceutical research since these molecules often exhibit unique biological activities due to their intricate structures.

Gelsemium is not a medical term itself, but it refers to the plant species Gelsemium sempervirens, also known as yellow jessamine or woodbine. In medicine, particularly in homeopathy, preparations made from this plant are used and referred to as Gelsemium.

Homeopathic Gelsemium is used primarily to treat various types of neuralgia (nerve pain), headaches, and certain symptoms associated with the flu or common cold, such as weakness, dizziness, and drowsiness. It's important to note that homeopathic remedies are not supported by scientific evidence and their effectiveness is a topic of ongoing debate in the medical community. Always consult with a healthcare professional before starting any new treatment.

I'm sorry for any confusion, but there seems to be a mistake in your question. "Pacific States" is not a recognized medical term or concept. The term "Pacific" usually refers to the Pacific Ocean or regions near it, and "states" typically refers to political divisions like countries or states within a country. If you're referring to a specific medical term that includes these words, could you please provide more context or clarify your question? I'm here to help!

Drug screening assays for antitumor agents are laboratory tests used to identify and evaluate the effectiveness of potential drugs or compounds that can inhibit the growth of tumor cells or induce their death. These assays are typically performed in vitro (in a test tube or petri dish) using cell cultures of various types of cancer cells.

The assays measure different parameters such as cell viability, proliferation, apoptosis (programmed cell death), and cytotoxicity to determine the ability of the drug to kill or inhibit the growth of tumor cells. The results of these assays can help researchers identify promising antitumor agents that can be further developed for clinical use in cancer treatment.

There are different types of drug screening assays for antitumor agents, including high-throughput screening (HTS) assays, which allow for the rapid and automated testing of a large number of compounds against various cancer cell lines. Other types of assays include phenotypic screening assays, target-based screening assays, and functional screening assays, each with its own advantages and limitations.

Overall, drug screening assays for antitumor agents play a critical role in the development of new cancer therapies by providing valuable information on the activity and safety of potential drugs, helping to identify effective treatments and reduce the time and cost associated with bringing new drugs to market.

Aerial parts of plants refer to the above-ground portions of a plant, including leaves, stems, flowers, and fruits. These parts are often used in medicine, either in their entirety or as isolated extracts, to take advantage of their medicinal properties. The specific components of aerial parts that are used in medicine can vary depending on the plant species and the desired therapeutic effects. For example, the leaves of some plants may contain active compounds that have anti-inflammatory or analgesic properties, while the flowers of others may be rich in antioxidants or compounds with sedative effects. In general, aerial parts of plants are used in herbal medicine to treat a wide range of conditions, including respiratory, digestive, and nervous system disorders, as well as skin conditions and infections.

Prenylation is a post-translational modification process in which a prenyl group, such as a farnesyl or geranylgeranyl group, is added to a protein covalently. This modification typically occurs at a cysteine residue within a CAAX motif (C is cysteine, A is an aliphatic amino acid, and X is any amino acid) found at the carboxyl-terminus of the protein. Prenylation plays a crucial role in membrane association, protein-protein interactions, and intracellular trafficking of proteins, particularly those involved in signal transduction pathways.

High-performance liquid chromatography (HPLC) is a type of chromatography that separates and analyzes compounds based on their interactions with a stationary phase and a mobile phase under high pressure. The mobile phase, which can be a gas or liquid, carries the sample mixture through a column containing the stationary phase.

In HPLC, the mobile phase is a liquid, and it is pumped through the column at high pressures (up to several hundred atmospheres) to achieve faster separation times and better resolution than other types of liquid chromatography. The stationary phase can be a solid or a liquid supported on a solid, and it interacts differently with each component in the sample mixture, causing them to separate as they travel through the column.

HPLC is widely used in analytical chemistry, pharmaceuticals, biotechnology, and other fields to separate, identify, and quantify compounds present in complex mixtures. It can be used to analyze a wide range of substances, including drugs, hormones, vitamins, pigments, flavors, and pollutants. HPLC is also used in the preparation of pure samples for further study or use.

Harringtonines are a group of alkaloids isolated from the plant *Cephalotaxus harringtonia* (also known as Platycladus orientalis), which has been used in traditional Chinese medicine. These compounds have been found to exhibit antitumor and anti-leukemic activities, and they are believed to work by inhibiting the formation of microtubules, which are critical for cell division.

Specifically, harringtonines bind to tubulin, a protein that makes up microtubules, and prevent it from forming stable structures. This leads to disruption of the mitotic spindle, which is necessary for chromosome separation during cell division. As a result, cells are unable to divide properly and undergo apoptosis (programmed cell death).

Harringtonines have been studied in clinical trials as potential cancer treatments, but their use is limited due to their narrow therapeutic index and significant side effects, including neurotoxicity and myelosuppression. Further research is needed to develop more targeted and less toxic therapies based on these compounds.

Tomatine is not a medical term, but a chemical compound found in plants, specifically in the leaves and stems of green tomatoes and in higher concentrations in the roots and flowers. It is a glycoalkaloid, which is a type of toxic compound that some plants produce to deter pests.

In the context of human health, tomatine has been studied for its potential effects on the body. Some research suggests that it may have anti-cancer properties, but more studies are needed to confirm these findings and determine whether it has any therapeutic value. It's important to note that tomatine can be toxic in high concentrations, so it should not be consumed in large amounts or as a supplement without medical supervision.

Monoterpenes are a class of terpenes that consist of two isoprene units and have the molecular formula C10H16. They are major components of many essential oils found in plants, giving them their characteristic fragrances and flavors. Monoterpenes can be further classified into various subgroups based on their structural features, such as acyclic (e.g., myrcene), monocyclic (e.g., limonene), and bicyclic (e.g., pinene) compounds. In the medical field, monoterpenes have been studied for their potential therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, more research is needed to fully understand their mechanisms of action and clinical applications.

"Lycoris" is a term that pertains to a genus of herbaceous, flowering plants in the amaryllis family (Amaryllidaceae). These plants are native to eastern and southern Asia, and they are known for their attractive, funnel-shaped flowers that bloom in late summer or early fall.

However, it seems that you may be looking for a medical definition of "Lycoris." In this context, there is no widely recognized medical term called "Lycoris." It's possible that you might be referring to "lycorine," which is a toxic alkaloid found in several plants of the Amaryllidaceae family, including those of the genus Lycoris.

Lycorine has shown potential as an anticancer agent in laboratory studies, but its clinical use is not established due to its high toxicity and limited research on its safety and efficacy in humans. It's important to note that lycorine should only be used under the supervision of medical professionals for experimental or therapeutic purposes.

"Cryptocarya" is a genus of flowering plants in the family Lauraceae, which includes trees and shrubs that are native to tropical regions of the world. These plants have simple, alternate leaves and small flowers with both male and female reproductive structures. The fruits of many species are fleshy and drupel-like, containing a single seed.

The name "Cryptocarya" comes from the Greek words "kryptos," meaning hidden, and "karpos," meaning fruit, which refers to the fact that the fruits of some species are enclosed within fleshy structures or bracts.

It is important to note that "Cryptocarya" is not a medical term, but rather a taxonomic name used in botany to classify and describe a particular group of plants. While some species of Cryptocarya may have medicinal uses, the genus itself does not have a specific medical definition or application.

Hydrastis is the genus name for Hydrastis canadensis, also known as goldenseal. It is a perennial herb native to North America, and its roots and rhizomes have been used in traditional medicine for various purposes. The active compounds in goldenseal include alkaloids such as hydrastine, berberine, and canadine, which are believed to have antibacterial, anti-inflammatory, and astringent properties.

However, it is important to note that the use of Hydrastis and its preparations as a medicine should be under the guidance of a healthcare professional, as there may be potential risks and interactions with other medications. Additionally, overharvesting of goldenseal in the wild has led to concerns about its sustainability, so it is recommended to use cultivated sources instead.

Molecular conformation, also known as spatial arrangement or configuration, refers to the specific three-dimensional shape and orientation of atoms that make up a molecule. It describes the precise manner in which bonds between atoms are arranged around a molecular framework, taking into account factors such as bond lengths, bond angles, and torsional angles.

Conformational isomers, or conformers, are different spatial arrangements of the same molecule that can interconvert without breaking chemical bonds. These isomers may have varying energies, stability, and reactivity, which can significantly impact a molecule's biological activity and function. Understanding molecular conformation is crucial in fields such as drug design, where small changes in conformation can lead to substantial differences in how a drug interacts with its target.

"Cephaelis" is a genus of plants in the family Rubiaceae, which includes several species that are native to tropical regions of the Americas. One well-known species in this genus is Cephaelis ipecacuanha, also known as ipecacuanha or ipecac. The roots and rhizomes of this plant contain alkaloids such as emetine and cephaeline, which have been used historically as an expectorant and emetic to induce vomiting in cases of poisoning. However, due to potential serious side effects, the use of ipecac syrup is no longer recommended for treating poisonings or encouraging vomiting.

It's important to note that medical professionals should be consulted for advice on treating medical conditions, and self-treatment with substances like ipecac can be dangerous.

"Solanaceae" is not a medical term but a taxonomic category in biology, referring to the Nightshade family of plants. This family includes several plants that have economic and medicinal importance, as well as some that are toxic or poisonous. Some common examples of plants in this family include:

- Solanum lycopersicum (tomato)
- Solanum tuberosum (potato)
- Capsicum annuum (bell pepper and chili pepper)
- Nicotiana tabacum (tobacco)
- Atropa belladonna (deadly nightshade)
- Hyoscyamus niger (henbane)

While Solanaceae isn't a medical term itself, certain plants within this family have medical significance. For instance, some alkaloids found in these plants can be used as medications or pharmaceutical precursors, such as atropine and scopolamine from Atropa belladonna, hyoscine from Hyoscyamus niger, and capsaicin from Capsicum species. However, it's important to note that many of these plants also contain toxic compounds, so they must be handled with care and used only under professional supervision.

I'm sorry for any confusion, but "Plant Structures" is not a medical term. It is a term used in the field of botany to refer to the different parts of a plant, such as roots, stems, leaves, flowers, and fruits. Each of these structures has specific functions that contribute to the overall growth, reproduction, and survival of the plant. If you have any questions related to biology or botany, I'd be happy to try and help answer them!

Oxytropis is a genus of flowering plants in the legume family, Fabaceae. It is native to temperate regions of the Northern Hemisphere, primarily in North America and Asia. Some common names for Oxytropis include locoweeds and wild peas.

In a medical context, Oxytropis species are most well-known for containing toxic alkaloids that can cause serious poisoning in livestock, particularly cattle, sheep, and goats. The toxins, including swainsonine and other indolizidine alkaloids, can affect the nervous system and cause symptoms such as weakness, tremors, blindness, and ultimately death.

While Oxytropis poisoning is not a direct concern for human health, it is important for medical professionals to be aware of its potential impact on animal health in rural and agricultural communities.

"Agelas" is a genus of demosponges, also known as marine sponges, that belong to the family Agelasidae. These sponges are commonly found in tropical and subtropical waters around the world. They are known for their distinctive skeletal structures, which are made up of fused spicules (small, needle-like structures) that form a rigid framework. Some species of Agelas contain compounds with potential medicinal properties, such as anti-inflammatory and antiviral agents. However, there is no specific medical definition or use of the term "Agelas."

"Ipomoea" is a botanical term that refers to a genus of plants in the morning glory family, Convolvulaceae. These plants are primarily found in tropical and warm temperate regions around the world. Some species of Ipomoea have medicinal uses, but it's important to note that 'Ipomoea' itself is not a medical term or concept.

For instance, one species, Ipomoea batatas, commonly known as sweet potato, has been used in traditional medicine for various purposes, such as treating wounds and gastrointestinal disorders. However, any medicinal use would refer to the specific plant or extract, not simply the genus name 'Ipomoea'.

As always, if you're considering using any plant or herb for medicinal purposes, it's crucial to consult with a healthcare provider first to ensure safety and efficacy.

According to the United States Food and Drug Administration (FDA), biological products are "products that are made from or contain a living organism or its derivatives, such as vaccines, blood and blood components, cells, genes, tissues, and proteins." These products can be composed of sugars, proteins, nucleic acids, or complex combinations of these substances, and they can come from many sources, including humans, animals, microorganisms, or plants.

Biological products are often used to diagnose, prevent, or treat a wide range of medical conditions, and they can be administered in various ways, such as through injection, inhalation, or topical application. Because biological products are derived from living organisms, their manufacturing processes can be complex and must be tightly controlled to ensure the safety, purity, and potency of the final product.

It's important to note that biological products are not the same as drugs, which are chemically synthesized compounds. While drugs are designed to interact with specific targets in the body, such as enzymes or receptors, biological products can have more complex and varied mechanisms of action, making them potentially more difficult to characterize and regulate.

"Crinum" is a genus of perennial herbaceous plants that belong to the family Amaryllidaceae. It includes several species of flowering plants, commonly known as "crinums" or "swamp lilies." These plants are native to various regions around the world, including Africa, Asia, and the Americas. They are characterized by their large, showy flowers that come in a variety of colors such as white, pink, red, and purple.

While "crinum" is not a medical term per se, some species of this plant have been used in traditional medicine for various purposes. For example, the bulbs of Crinum latifolium are used in Indian traditional medicine to treat skin diseases, inflammation, and fever. Similarly, the roots of Crinum pedunculatum have been used by indigenous Australians to treat burns, sores, and wounds.

However, it is important to note that the use of these plants as medicinal remedies has not been extensively studied in clinical trials, and their safety and efficacy are not well-established. Therefore, they should not be used as a substitute for evidence-based medical treatments.

"Lolium" is not a term commonly used in medical definitions. It is actually the genus name for a group of plants that are more commonly known as ryegrasses. These plants belong to the family Poaceae and include several species that are widely used as pasture, hay, or lawn grasses.

While not directly related to human health, these plants can have indirect effects on health, particularly in agricultural settings. For example, certain ryegrass species can host a parasitic nematode called "Haemonchus contortus," which can infect and cause disease in livestock that graze on the grass.

However, without further context, it's challenging to provide a specific medical definition for "Lolium." If you have more information or if this term is being used in a specific medical context, please provide those details so I can give a more accurate response.

Iridoids are a type of naturally occurring compounds that are widely distributed in the plant kingdom. They are characterized by the presence of a cyclopentanoid structure fused to a monoterpene unit. Iridoids have a wide range of biological activities, including anti-inflammatory, analgesic, and antioxidant effects. Some iridoids also have potential therapeutic benefits in the treatment of various diseases, such as cancer and neurodegenerative disorders.

In a medical context, iridoids may be mentioned in relation to their presence in certain medicinal plants or herbs used in traditional medicine, or in research investigating their potential pharmacological properties. However, it is important to note that the use of iridoid-containing plants or supplements should only be done under the guidance of a qualified healthcare professional, as with any medical treatment.

Phenanthrenes are not typically defined in a medical context, but they are a class of organic compounds that have a polycyclic aromatic hydrocarbon structure consisting of three benzene rings fused together. They can be found in some natural products and have been studied for their potential pharmacological properties. Some phenanthrenes have shown anti-inflammatory, antioxidant, and cytotoxic activities, among others. However, more research is needed to fully understand their therapeutic potential and safety profile.

"Nelumbo" is the scientific genus name for the lotus flower, which includes two species: Nelumbo nucifera (also known as Sacred Lotus) and Nelumbo lutea (American Lotus). These aquatic plants are known for their large, beautiful flowers that bloom on the surface of the water. While "Nelumbo" is a term from plant taxonomy and botany, it does not have a specific medical definition as such. However, various parts of Nelumbo plants have been used in traditional medicine across different cultures for treating various health conditions. For instance, the seeds, leaves, and roots of Nelumbo nucifera are used in Traditional Chinese Medicine to treat several ailments like diarrhea, fever, and skin diseases. Nonetheless, it is essential to consult healthcare professionals before using any plant or herbal remedy for medicinal purposes.

"Fritillaria" is a genus of plants that includes around 140 species, many of which have been used in traditional medicine for various purposes. In a medical context, "Fritillaria" usually refers to the bulbs of certain Fritillaria species, such as Fritillaria cirrhosa and Fritillaria thunbergii, which are used in Traditional Chinese Medicine (TCM).

In TCM, Fritillaria bulbs are known as "Beimu" or "Chuanbei," and they have been used to treat respiratory conditions such as coughs, bronchitis, and asthma. The active components of Fritillaria include alkaloids, steroidal saponins, and polysaccharides, which are believed to have anti-inflammatory, expectorant, and antitussive effects.

However, it's important to note that the use of Fritillaria in medicine is not well-studied in Western medicine, and its effectiveness and safety are not established. Moreover, some Fritillaria species contain toxic compounds, so it's essential to consult a healthcare professional before using any Fritillaria products for medicinal purposes.

I'm sorry for any confusion, but "Murraya" is not a term commonly used in medical definitions. It is actually a genus of tropical and subtropical evergreen trees and shrubs in the family Rutaceae, also known as the rue or citrus family. The most common species is Murraya paniculata, which is often used as an ornamental plant and is commonly known as the "Orange Jessamine" or "Chinese Box."

If you have any questions about a medical condition or term, I'd be happy to try to help with that.

Menispermaceae is not a medical term, but a botanical term referring to a family of flowering plants. It includes around 70 genera and 450-550 species of woody vines, shrubs, and small trees. Some members of this family contain alkaloids and have been used in traditional medicine in various parts of the world. However, it is important to note that the use of these plants as medicine should be done under the guidance of a healthcare professional, as they can also contain toxic compounds.

Inhibitory Concentration 50 (IC50) is a measure used in pharmacology, toxicology, and virology to describe the potency of a drug or chemical compound. It refers to the concentration needed to reduce the biological or biochemical activity of a given substance by half. Specifically, it is most commonly used in reference to the inhibition of an enzyme or receptor.

In the context of infectious diseases, IC50 values are often used to compare the effectiveness of antiviral drugs against a particular virus. A lower IC50 value indicates that less of the drug is needed to achieve the desired effect, suggesting greater potency and potentially fewer side effects. Conversely, a higher IC50 value suggests that more of the drug is required to achieve the same effect, indicating lower potency.

It's important to note that IC50 values can vary depending on the specific assay or experimental conditions used, so they should be interpreted with caution and in conjunction with other measures of drug efficacy.

Biosynthetic pathways refer to the series of biochemical reactions that occur within cells and living organisms, leading to the production (synthesis) of complex molecules from simpler precursors. These pathways involve a sequence of enzyme-catalyzed reactions, where each reaction builds upon the product of the previous one, ultimately resulting in the formation of a specific biomolecule.

Examples of biosynthetic pathways include:

1. The Krebs cycle (citric acid cycle) - an essential metabolic pathway that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins.
2. Glycolysis - a process that breaks down glucose into pyruvate to generate ATP and NADH.
3. Gluconeogenesis - the synthesis of glucose from non-carbohydrate precursors such as lactate, pyruvate, glycerol, and certain amino acids.
4. Fatty acid synthesis - a process that produces fatty acids from acetyl-CoA and malonyl-CoA through a series of reduction reactions.
5. Amino acid synthesis - the production of various amino acids from simpler precursors, often involving intermediates in central metabolic pathways like the Krebs cycle or glycolysis.
6. Steroid biosynthesis - the formation of steroids from simple precursors such as cholesterol and its derivatives.
7. Terpenoid biosynthesis - the production of terpenes, terpenoids, and sterols from isoprene units (isopentenyl pyrophosphate).
8. Nucleotide synthesis - the generation of nucleotides, the building blocks of DNA and RNA, through complex biochemical pathways involving various precursors and cofactors.

Understanding biosynthetic pathways is crucial for comprehending cellular metabolism, developing drugs that target specific metabolic processes, and engineering organisms with desired traits in synthetic biology and metabolic engineering applications.

Bridged compounds are a type of organic compound where two parts of the molecule are connected by a chain of atoms, known as a bridge. This bridge can consist of one or more atoms and can be made up of carbon, oxygen, nitrogen, or other elements. The bridge can be located between two carbon atoms in a hydrocarbon, for example, creating a bridged bicyclic structure. These types of compounds are important in organic chemistry and can have unique chemical and physical properties compared to non-bridged compounds.

Ranunculaceae is a family of flowering plants, also known as the buttercup family. It includes over 2,000 species distributed across 58 genera. The plants in this family are characterized by their showy, often brightly colored flowers and typically have numerous stamens and carpels. Many members of Ranunculaceae contain toxic compounds, which can be irritants or even poisonous if ingested. Examples of plants in this family include buttercups, delphiniums, monkshood, and columbines.

Heterocyclic compounds are organic molecules that contain a ring structure made up of at least one atom that is not carbon, known as a heteroatom. These heteroatoms can include nitrogen, oxygen, sulfur, or other elements.

Bridged-ring heterocyclic compounds are a specific type of heterocyclic compound that contain two or more cyclic structures (rings) that are linked together by one or more atoms or groups of atoms, known as bridges. These bridges can be composed of carbon-carbon bonds or may include heteroatoms.

The presence of the bridged rings and heteroatoms in these compounds can significantly affect their chemical and physical properties, making them important in a variety of applications, including pharmaceuticals, agrochemicals, and materials science.

Mass spectrometry with electrospray ionization (ESI-MS) is an analytical technique used to identify and quantify chemical species in a sample based on the mass-to-charge ratio of charged particles. In ESI-MS, analytes are ionized through the use of an electrospray, where a liquid sample is introduced through a metal capillary needle at high voltage, creating an aerosol of charged droplets. As the solvent evaporates, the analyte molecules become charged and can be directed into a mass spectrometer for analysis.

ESI-MS is particularly useful for the analysis of large biomolecules such as proteins, peptides, and nucleic acids, due to its ability to gently ionize these species without fragmentation. The technique provides information about the molecular weight and charge state of the analytes, which can be used to infer their identity and structure. Additionally, ESI-MS can be interfaced with separation techniques such as liquid chromatography (LC) for further purification and characterization of complex samples.

Tetrahydroisoquinolines (TIQs) are not a medical condition, but rather a class of organic compounds that have been studied in the field of medicine and neuroscience. TIQs are naturally occurring substances found in various foods, beverages, and plants, as well as produced endogenously in the human body. They have been shown to have various pharmacological activities, including acting as weak psychoactive agents, antioxidants, and inhibitors of certain enzymes. Some TIQs have also been implicated in the pathophysiology of certain neurological disorders such as Parkinson's disease. However, more research is needed to fully understand their roles and potential therapeutic applications.

I apologize for any confusion, but "Pinus ponderosa" is not a medical term. It is the scientific name for a species of pine tree commonly known as the western yellow pine or ponderosa pine. This tree is native to North America and is one of the most widely distributed pine species in the continent.

Here's a brief overview of its botanical characteristics:

Kingdom: Plantae
Division: Pinophyta
Class: Pinopsida
Order: Pinales
Family: Pinaceae
Genus: Pinus
Species: P. ponderosa

The ponderosa pine is a large evergreen tree, reaching heights of 150-250 feet (46-76 meters) tall and trunk diameters up to 8 feet (2.4 meters). Its needle-like leaves are grouped in bundles of three, and its cones are long and slender, typically 3-6 inches (7.6-15.2 cm) in length.

If you have any questions related to medical terminology or healthcare topics, please feel free to provide them, and I'd be happy to help.

Thebaine is a naturally occurring alkaloid found in the opium poppy (Papaver somniferum) and is defined medically as follows:

A benzylisoquinoline alkaloid, Thebaine is a potent opioid agonist with complex pharmacology. It acts as an antagonist at mu and delta receptors while exhibiting agonist activity at kappa receptors. Due to its strong physiological effects and potential for abuse, thebaine has limited therapeutic use. However, it serves as a crucial intermediate in the semi-synthesis of various opioid analgesics, such as oxycodone, hydrocodone, and nalbuphine.

Please note that this definition is intended for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment.

'Toxic plants' refer to those species of plants that contain toxic substances capable of causing harmful effects or adverse health reactions in humans and animals when ingested, touched, or inhaled. These toxins can cause a range of symptoms from mild irritation to serious conditions such as organ failure, paralysis, or even death depending on the plant, the amount consumed, and the individual's sensitivity to the toxin.

Toxic plants may contain various types of toxins, including alkaloids, glycosides, proteins, resinous substances, and essential oils. Some common examples of toxic plants include poison ivy, poison oak, nightshade, hemlock, oleander, castor bean, and foxglove. It is important to note that some parts of a plant may be toxic while others are not, and the toxicity can also vary depending on the stage of growth or environmental conditions.

If you suspect exposure to a toxic plant, it is essential to seek medical attention immediately and, if possible, bring a sample of the plant for identification.

Swainsonine is not a medical condition or disease, but rather a toxin that can cause a medical condition known as "locoism" in animals. Swainsonine is produced by certain plants, including some species of the genera Swainsona and Astragalus, which are commonly known as locoweeds.

Swainsonine inhibits an enzyme called alpha-mannosidase, leading to abnormal accumulation of mannose-rich oligosaccharides in various tissues and organs. This can result in a range of clinical signs, including neurological symptoms such as tremors, ataxia (loss of coordination), and behavioral changes; gastrointestinal symptoms such as diarrhea, weight loss, and decreased appetite; and reproductive problems.

Locoism is most commonly seen in grazing animals such as cattle, sheep, and horses that consume large quantities of locoweeds over an extended period. It can be difficult to diagnose and treat, and prevention through management practices such as rotational grazing and avoiding the introduction of toxic plants into pastures is often the best approach.

Ellipticines are a class of naturally occurring alkaloids that have been isolated from various plants, including those in the family Apocynaceae. These compounds have been found to exhibit various biological activities, including anti-cancer and anti-microbial properties.

Ellipticines have a unique chemical structure, characterized by a planar, aromatic core with two side chains that contain nitrogen atoms. This structure allows ellipticines to intercalate into DNA, disrupting its normal function and leading to cell death. As a result, ellipticines have been studied as potential anti-cancer agents, particularly for the treatment of drug-resistant cancers.

In addition to their anti-cancer properties, ellipticines have also been found to exhibit antibacterial, antifungal, and antiparasitic activities. However, further research is needed to fully understand the mechanisms behind these effects and to determine the safety and efficacy of ellipticines as therapeutic agents.

A rhizome is not typically used as a medical term, but it is a term borrowed from botany that has been adopted in some areas of medicine, particularly in psychiatry and psychotherapy.

In its original botanical sense, a rhizome is a horizontal stem of a plant that grows underground, often sending out roots and shoots from its nodes. This growth pattern is contrasted with that of a root system, which grows downward, and a stem system, which grows upward.

In psychiatry and psychotherapy, the term "rhizome" has been used as a metaphor to describe a non-hierarchical and decentralized approach to understanding mental processes and subjectivity. The rhizome model emphasizes the complexity, multiplicity, and interconnectedness of these processes, and rejects simplistic or reductionist explanations that focus on a single cause or origin. Instead, it encourages a more holistic and dynamic view of mental life, one that is open to multiple perspectives and interpretations.

It's important to note that the use of the term "rhizome" in this context is metaphorical and not medical in the strict sense. It is a way of thinking about mental processes and subjectivity that has been influenced by poststructuralist and feminist theories, among others.

'Strychnos nux-vomica' is a plant species also known as the poison nut tree or strychnine tree. Its seeds, known as nux vomica, contain several alkaloids including strychnine and brucine, which have been used in medicine for their stimulant and convulsant properties. However, due to the high toxicity and narrow therapeutic index of these compounds, the use of 'Strychnos nux-vomica' in modern medicine is very limited and generally not recommended.

It's important to note that while some alkaloids found in 'Strychnos nux-vomica' have been used in homeopathy, there is a lack of scientific evidence supporting their efficacy, and they should only be used under the guidance of a qualified healthcare professional.

Iridoid glucosides are a type of plant-based compounds that are characterized by their iridoid structure, which is a cyclic organic compound containing a cyclopentane ring fused to a six-membered unsaturated carbocycle. These compounds are often found in plants as glycosides, meaning they are combined with a sugar molecule such as glucose.

Iridoid glucosides have been identified in a variety of plant families, including the Lamiaceae (mint family), Scrophulariaceae (figwort family), and Rubiaceae (coffee family). Some examples of iridoid glucosides include geniposide, which is found in the fruit of the gardenia plant, and aucubin, which is found in the leaves of the eucommia tree.

Iridoid glucosides have been studied for their potential medicinal properties, including anti-inflammatory, antioxidant, and antimicrobial effects. However, more research is needed to fully understand their mechanisms of action and potential therapeutic uses.

"Piper" is not a medical term. It is a genus of plants in the family Piperaceae, which includes black pepper and many other species. In some cases, "piper" may refer to piperazine, a class of medications used to treat various conditions such as intestinal worm infections and symptoms of mental disorders. However, it's not a commonly used medical term.

Angiosperms, also known as flowering plants, are a group of plants that produce seeds enclosed within an ovary. The term "angiosperm" comes from the Greek words "angeion," meaning "case" or "capsule," and "sperma," meaning "seed." This group includes the majority of plant species, with over 300,000 known species.

Angiosperms are characterized by their reproductive structures, which consist of flowers. The flower contains male and female reproductive organs, including stamens (which produce pollen) and carpels (which contain the ovules). After fertilization, the ovule develops into a seed, while the ovary matures into a fruit, which provides protection and nutrition for the developing embryo.

Angiosperms are further divided into two main groups: monocots and eudicots. Monocots have one cotyledon or embryonic leaf, while eudicots have two. Examples of monocots include grasses, lilies, and orchids, while examples of eudicots include roses, sunflowers, and legumes.

Angiosperms are ecologically and economically important, providing food, shelter, and other resources for many organisms, including humans. They have evolved a wide range of adaptations to different environments, from the desert to the ocean floor, making them one of the most diverse and successful groups of plants on Earth.

Indole is not strictly a medical term, but it is a chemical compound that can be found in the human body and has relevance to medical and biological research. Indoles are organic compounds that contain a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring.

In the context of medicine, indoles are particularly relevant due to their presence in certain hormones and other biologically active molecules. For example, the neurotransmitter serotonin contains an indole ring, as does the hormone melatonin. Indoles can also be found in various plant-based foods, such as cruciferous vegetables (e.g., broccoli, kale), and have been studied for their potential health benefits.

Some indoles, like indole-3-carbinol and diindolylmethane, are found in these vegetables and can have anti-cancer properties by modulating estrogen metabolism, reducing inflammation, and promoting cell death (apoptosis) in cancer cells. However, it is essential to note that further research is needed to fully understand the potential health benefits and risks associated with indoles.

'Eschscholzia' is the medical/botanical name for the genus of plants that includes California poppy (Eschscholzia californica). It is a species of poppy that is native to the United States and Mexico. The plant contains several alkaloids, including escholtzine, which has been reported to have sedative and pain-relieving properties. However, it's important to note that the use of California poppy as a medicine is not well-studied and should not be used as a substitute for professional medical advice.

Endophytes are microorganisms, typically bacteria or fungi, that live inside the tissues of plants without causing any visible disease or harm to the plant. They can be found in almost all plant species and are known to exist in a mutualistic relationship with their host plants. Endophytes can provide various benefits to the plants such as growth promotion, increased resistance to pathogens, and protection against herbivores. Some endophytic fungi also produce bioactive compounds that have potential applications in medicine, agriculture, and industry.

Monocrotaline is not a medical condition but a toxic compound that is found in certain plants, including the Crotalaria species (also known as "rattlebox" or "crowtoe"). It has been used in research to create laboratory models of pulmonary hypertension. Ingestion or inhalation of monocrotaline can lead to serious health effects, including lung damage and death.

Therefore, there is no medical definition for 'Monocrotaline' as it is not a disease or condition.

The omasum is the third compartment of the ruminant stomach, located between the rumen and the abomasum. It is also known as the manyplies because of its structure, which consists of numerous folds or leaves that are arranged in a circular pattern. The main function of the omasum is to absorb water, electrolytes, and volatile fatty acids from the digesta that passes through it, helping to concentrate the solids and prepare them for further digestion in the abomasum.

Quinolines are a class of organic compounds that consist of a bicyclic structure made up of a benzene ring fused to a piperidine ring. They have a wide range of applications, but they are perhaps best known for their use in the synthesis of various medications, including antibiotics and antimalarial drugs.

Quinolone antibiotics, such as ciprofloxacin and levofloxacin, work by inhibiting the bacterial enzymes involved in DNA replication and repair. They are commonly used to treat a variety of bacterial infections, including urinary tract infections, pneumonia, and skin infections.

Quinoline-based antimalarial drugs, such as chloroquine and hydroxychloroquine, work by inhibiting the parasite's ability to digest hemoglobin in the red blood cells. They are commonly used to prevent and treat malaria.

It is important to note that quinolines have been associated with serious side effects, including tendinitis and tendon rupture, nerve damage, and abnormal heart rhythms. As with any medication, it is important to use quinolines only under the supervision of a healthcare provider, and to follow their instructions carefully.

Cinchona is a genus of tropical Cinchona trees or shrubs, native to western South America. The bark of these plants contains a variety of alkaloids, including quinine and cinchonine, which have been used historically in the treatment of malaria and other febrile illnesses.

In medical terminology, "Cinchona" can also refer to the dried bark of these trees or shrubs, which is used to prepare various medicinal preparations. The term may also be used more broadly to describe any medication that contains alkaloids derived from Cinchona plants, including synthetic derivatives such as chloroquine and hydroxychloroquine.

It's important to note that while Cinchona bark and its derivatives have been used for centuries in traditional medicine, their use is not without risks or side effects. In particular, high doses of quinine can be toxic and may cause a range of adverse reactions, including tinnitus, hearing loss, visual disturbances, and cardiac arrhythmias. As such, the use of Cinchona-derived medications should always be supervised by a qualified healthcare professional.

Indicators and reagents are terms commonly used in the field of clinical chemistry and laboratory medicine. Here are their definitions:

1. Indicator: An indicator is a substance that changes its color or other physical properties in response to a chemical change, such as a change in pH, oxidation-reduction potential, or the presence of a particular ion or molecule. Indicators are often used in laboratory tests to monitor or signal the progress of a reaction or to indicate the end point of a titration. A familiar example is the use of phenolphthalein as a pH indicator in acid-base titrations, which turns pink in basic solutions and colorless in acidic solutions.

2. Reagent: A reagent is a substance that is added to a system (such as a sample or a reaction mixture) to bring about a chemical reaction, test for the presence or absence of a particular component, or measure the concentration of a specific analyte. Reagents are typically chemicals with well-defined and consistent properties, allowing them to be used reliably in analytical procedures. Examples of reagents include enzymes, antibodies, dyes, metal ions, and organic compounds. In laboratory settings, reagents are often prepared and standardized according to strict protocols to ensure their quality and performance in diagnostic tests and research applications.

Pilocarpus is not a medical condition or diagnosis, but rather it refers to a type of plant genus (Pilocarpus spp.) that contains several species of shrubs and small trees. The most well-known species in this genus is Pilocarpus jaborandi, which is native to South America.

Extracts from the leaves of Pilocarpus plants contain a chemical compound called pilocarpine, which has been used medically for its parasympathomimetic effects. Specifically, it can stimulate the parasympathetic nervous system, leading to increased salivation, sweating, and contraction of the smooth muscles in the eyes and gastrointestinal tract.

Pilocarpine is primarily used in medical practice to treat dry mouth (xerostomia) caused by radiation therapy or certain medications, as well as to reduce intraocular pressure in patients with glaucoma. It can be administered orally, topically (as eye drops), or sublingually (under the tongue).

Therefore, a medical definition of Pilocarpus would refer to a genus of plants that contain pilocarpine, a compound used in medical treatments for its parasympathomimetic effects.

I apologize for the confusion, but "Marine Biology" is not a medical term. Instead, it is a branch of biology that deals with the study of marine organisms, their behaviors, and their interactions with the marine environment. Marine biologists investigate various aspects of marine life, such as the ecology, physiology, and genetics of marine plants, animals, and microorganisms. They also study the impact of human activities on marine ecosystems and work towards conservation efforts to protect these environments.

"Paullinia" is a botanical name, referring to a genus of plants in the soapberry family (Sapindaceae). It includes several species that are native to the Americas, particularly in Central and South America. Some of these plants have traditional medicinal uses, and some of their chemical constituents have been studied for potential pharmacological effects. However, "Paullinia" itself is not a medical term or diagnosis.

One of the most well-known species in this genus is Paullinia cupana, commonly known as guarana. Guarana seeds contain high levels of caffeine and have been used in traditional medicine as a stimulant and to treat various conditions such as fever, headache, and gastrointestinal issues. However, it's important to note that the use of these plants as medicines may come with risks and should be done under the guidance of a healthcare professional.

Spectrophotometry, Infrared is a scientific analytical technique used to measure the absorption or transmission of infrared light by a sample. It involves the use of an infrared spectrophotometer, which directs infrared radiation through a sample and measures the intensity of the radiation that is transmitted or absorbed by the sample at different wavelengths within the infrared region of the electromagnetic spectrum.

Infrared spectroscopy can be used to identify and quantify functional groups and chemical bonds present in a sample, as well as to study the molecular structure and composition of materials. The resulting infrared spectrum provides a unique "fingerprint" of the sample, which can be compared with reference spectra to aid in identification and characterization.

Infrared spectrophotometry is widely used in various fields such as chemistry, biology, pharmaceuticals, forensics, and materials science for qualitative and quantitative analysis of samples.

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... as well as some furoquinoline alkaloids and acridine alkaloids. Strychnine and brucine, alkaloids of the nux vomica, which have ... Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine, which are important due to their therapeutic ... Quinoline alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from ... Some quinoline alkaloids show antiseptic, convulsive or antineoplastic effects. Alkaloids with a quinoline partial structure ...
The carbazole alkaloids are natural products of the indole alkaloid type, derived from carbazole. Carbazole alkaloids with ... Entry on carbazole alkaloids. In: Römpp Online. Georg Thieme Verlag, accessed May 31, 2020. Eberhard Breitmaier (1997), ... Some carbazole alkaloids, especially glybomin B, have been isolated from Glycosmis pentaphylla. Representatives include, among ... CS1 maint: multiple names: authors list, Commons category link is on Wikidata, Alkaloids). ...
... was a subsidiary of the United States pharmaceutical company Johnson & Johnson, but was formerly-as of 1980 ... The company patented a poppy variety called "Norman" which was stated, in the 1999 Tasmanian Alkaloids Poppy Grower's Bulletin ... ISBN 978-0-9820787-2-3. Tasmanian Alkaloids Website [1] v t e (CS1 errors: missing periodical, Articles with short description ... Extractas Bioscience (before called Tasmanian Alkaloids) is the largest opium poppy processing company in the Australian state ...
... are found in spotted hemlock. The mature fruits may contain up to 3.5% alkaloids. The main alkaloid is coniine ... Conium alkaloids are natural products of the piperidine alkaloid type. ... Coniine (+)-Conhydrin (+)-Pseudoconhydrin Most Conium alkaloids are liquid at room temperature. 500 mg of coniin is fatal to a ...
They also include the benzyl(tetrahydro)isoquinoline alkaloids. Benzylisoquinoline alkaloids are found in several plant ... the phthalideisoquinoline alkaloids, the morphinans, the protoberberine alkaloids, and the pavins. Among the known individual ... The benzylisoquinoline alkaloids are natural products that can be classified as isoquinoline alkaloidss and are derived from ... 8 (Benzylisoquinoline alkaloids, p. 8, at Google Books). Jennifer M. Finefield, David H. Sherman, Martin Kreitman, Robert M. ...
... show a blue-green fluorescence so that they can be detected with UV light. Some alkaloids of this group are ... Acridone alkaloids are natural products derived from acridone. Acridone alkaloids are found in bark, wood, leaves and roots of ... 101,1326, ISBN 9783540265085 "Acridone alkaloid biosynthesis". Archived from the original on 12 June 2020. Retrieved 22 April ... CS1 German-language sources (de), Alkaloids by chemical classification). ...
... are natural products of the group of alkaloids, which are chemically derived from isoquinoline. They ... isoquinoline alkaloids can have different effects. The opium alkaloids may have sedative, psychotropic or analgesic properties ... The alkaloid tubocurarin is found in the hairy cartilage tree. There the Tubocurarin is extracted from the bark and roots. ... Isoquinoline alkaloids can be further classified based on their different chemical basic structures. The most common structural ...
... are natural products from the group of alkaloids, which are chemically derived from quinazoline. Some ... About 70 alkaloids with a quinazoline structure are known, which are mostly further classified as simple quinazolinones, ... Wikimedia Commons has media related to Quinazoline alkaloids. Entry on Peganin. at: Römpp Online. Georg Thieme Verlag, ... Vasicine Evodiamine Rutaecarpine Febrifugine Quinazoline alkaloids can be found mainly in plants, such as acanthaceae (Adhatoda ...
... are a class of alkaloids, nitrogen-containing chemical compounds widely found in plants, that contain a ... the areca alkaloids in betel and ricinine in castor oil. nicotine anabasine ricinine "Pyridine Alkaloids". Cornell University, ... Alkaloids with a pyridine partial structure are usually further subdivided according to their occurrence and their biogenetic ... Media related to Pyridine alkaloids at Wikimedia Commons v t e (Articles with short description, Short description matches ...
The pyrrolidine alkaloids are natural products chemically derived from pyrrolidine. Alkaloids with partial pyrrolidine ... Wood vine tiger bell (Codonopsis clematidea) Among the most important representatives of the pyrrolidine alkaloids are hygrin ... Furthermore, ruspolinone, norruspolinone and norruspoline also belong to this alkaloid group. (+)-Hygrine (-)-Codonopsinine ... and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (−)-Codonopsinine", The Journal of Organic Chemistry, vol. 72, ...
The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. Until 1956, it was ... The taxine alkaloids are cardiotoxins with taxine B being the most active. Taxine alkaloids have no medical uses but Paclitaxel ... Graf and Boeddeker discovered that taxine was actually a complex mixture of alkaloids rather than a single alkaloid. Using ... Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated ...
... are natural products characterized by pentacyclic structure. These alkaloids are commonly found in the ... Alkaloids, Heterocyclic compounds with 5 rings, Nitrogen heterocycles, Oxygen heterocycles). ...
One is Erythrina alkaloid, the other one is HomoErythrina alkaloid. The shared feature of Erythrina alkaloids is the ... The Erythrina alkaloids have three basic categories: dienoid, alkenoid and lactonic alkaloids. Some other different types of ... The configuration of the 5-carbon is always S in all known isolated alkaloids. Some of the Erythrina alkaloids have 3-alkyloxy ... Other works had shown that the alkaloids could show antiepileptic, anticonvulsant and tranquilizing effects. Some alkaloids ...
... are natural products from various alkaloid groups whose structure can be derived from indolizidine. ... Norsecurinine Most of the Tylophora alkaloids belong to the phenanthroindolizidine alkaloid family, including tylophorine, ... Notably, this alkaloid group includes pumiliotoxins, which are the toxins of the strawberry poison-dart frog. The polyhydroxy ... Main alkaloids of this group are Ipalbin and Ipomin. Furthermore, Ipalbidine and Ipohardine occur. (+)-Ipalbidine Swainsonine- ...
Both alkaloids find use as rat poisons and as optically active bases in the enantiomer separation of racemate acids. As early ... Strychnos alkaloids are natural products primarily found in the seeds of the strychnine tree (Strychnos nux-vomica) and in the ... When this article or the scientific literature names one of these alkaloids without adding another name, it actually states: ... The primary representative of this group of alkaloids are strychnine and brucine. Other notable representatives include vomicin ...
The proaporphin alkaloids and the aporphin alkaloids share a framework isomerism. The aporphine alkaloids usually have a ... The aporphine alkaloids are of interest mainly because of their similarity to morphine. The aporphine alkaloids are most ... After the benzylisoquinoline alkaloids they are the second largest group of isoquinoline alkaloids. At least 85 aporphine ... Aporphine alkaloids are naturally occurring chemical compounds from the group of alkaloids. ...
... are categorized as natural products of the isoquinoline alkaloid type. Corydalis alkaloids are primarily ... The representatives of Corydalis alkaloids include d-tetrahydrocoptisine (also known as d- or (+)-stylopine), d-canadine, and ... 1131-1137, doi:10.1002/cber.19310640530 J. Slavík, L. Slavíková (1979), "Alkaloids from Corydalis cava (L.) SCHW. et KOERTE", ... Historically, the powdered rhizomes of Corydalis alkaloid-containing plants enjoyed popularity as a vermifuge and menstrual ...
Aconitine is the main alkaloid in aconite. Diterpene alkaloids can be divided into two groups: The diterpene alkaloids, ... Diterpene alkaloids are natural products of the terpene alkaloid type. Veatchine is found in the bark of Garrya veatchii, a ... Among the C20 alkaloids is the atisine-type (atisine, hetidine, hetisine) and the veatchine-type (Veatchin, Napellin). Atisine ... characterized by a C20 parent body, and the norditerpene alkaloids, which are based on a hexacyclic C19 parent body. ...
... are natural products found in the plant family of the dogbane family (Apocynaceae). The alkaloid ... The alkaloids voacangin and voacristin were isolated from Voacanga africana. Representatives include tabernanthine, voacangine ... "Alkaloids of the Apocynaceae", Economic Botany pages, vol. 14, pp. 37-55, doi:10.1007/BF02859365 Lexicon of Medicinal Plants ...
... are natural products that have a quinolizidine structure; this includes the lupine alkaloids. ... While the lupine alkaloids (following their name) can be found in lupines, tinctorin, for example, was isolated from the dyer's ... The only quinolizidine alkaloid used therapeutically is sparteine, which has an antiarrhythmic and labor-promoting effect. E. ... Quinolizidine alkaloids defend plants against pests and diseases and breeding to reduce QA concentrations lowers these ...
... are natural products and so-called pseudoalkaloids. Dendrobium alkaloids are found in the genus Dendrobium ... Approximately 15 alkaloids belong to this group. Notable representatives include Dendrobin, Nobilonin, and Dendroxin. (-)- ... The Third Alkaloid from Dendrobium nobile", Chemical and Pharmaceutical Bulletin, vol. 14, no. 6, pp. 672-675, doi:10.1248/cpb. ...
... are a group of piperidine alkaloids found in the areca nut, the seeds of the areca palm (Areca catechu). Areca ... The main alkaloid is arecoline, which accounts for over 50% of the total alkaloid content. Other representatives include ... A roasting of dried nuts increases the proportion of arecoline in the total alkaloid content. Arecolin is a potent ... Arecoline Arecaidine Guvacoline Guvacine The total alkaloid content of the nuts increases during ripening and decreases upon ...
In nature, imidazole alkaloids are found both as secondary plant compounds and as byproducts of histidine metabolism in marine ... Imidazole alkaloids are a group of alkaloidss whose basic structure contains the imidazole ring system. ... One well-known imidazole alkaloid is pilocarpine, which is present in the leaves of Paraguay jaborandi. For instance, from the ... A well-known imidazole alkaloid is pilocarpine. Other representatives include. cynodin, cynometrin and odilin. (+)-Pilocarpine ...
The Lycopodium alkaloids are of interest due to their biological activity and unique skeletal characteristics, however, many ... "Lycopodine and the Lycopodium Alkaloids" (PDF). Archived from the original (PDF) on 2016-03-03. Retrieved 2013-08-11. dead link ... The 10-hydroxy Lycopodium alkaloids, which include 10-hydroxylycopodine, deacetylpaniculine, and paniculine, are a series of ... Articles with short description, Short description matches Wikidata, Alkaloids). ...
... of those contain alkaloids. Therefore, in the past the term "alkaloid" was associated with plants. The alkaloids content in ... attributed to isoquinoline alkaloids. Main classes of monomeric alkaloids are listed in the table below: Most alkaloids contain ... Most alkaloids are present in the raw plants in the form of salts of organic acids. The extracted alkaloids may remain salts or ... Medical use of alkaloid-containing plants has a long history, and, thus, when the first alkaloids were isolated in the 19th ...
Tropane alkaloids are a class of bicyclic [3.2.1] alkaloids and secondary metabolites that contain a tropane ring in their ... Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloids such as cocaine and ... They are not considered to be alkaloids per definition. The biosynthesis of the tropane alkaloids have attracted intense ... Hesse M (2002). Alkaloids: Nature's Curse or Blessing?. Weinheim: Wiley-VCH. p. 304. ISBN 978-3-906390-24-6. Ryzik M (10 June ...
"About Alkaloid". www.alkaloid.com.mk. Retrieved 2017-07-05. v t e (CS1 Macedonian-language sources (mk), Articles needing ... Alkaloid AD Skopje (Macedonian: Алкалоид АД Скопје) is a pharmaceutical company in North Macedonia which for eight decades, has ... Alkaloid AD is a joint stock company that consists of two profit centers: Pharmaceuticals and Chemicals, Cosmetics and ... Alkaloid official website, in Macedonian and English "Брокерска Куќа ЕУРОХАУС ад Скопје" (in Macedonian). Retrieved 2022-09-11 ...
Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene ... Ergot alkaloids are a class of hemiterpenoid indole alkaloids related to lysergic acid, which, in turn, is formed in a ... Indole alkaloids are distinguished depending on their biosynthesis. The two types of indole alkaloids are isoprenoids and non- ... Pirroloindole alkaloids are synthesized in living organisms in a similar way. Biosynthesis of ergot alkaloids begins with the ...
The piperidine alkaloids also include the sedum alkaloids (e.g. sedamine), pelletierine, the lobelia alkaloids (e.g. lobeline ... Piperidine alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from ... the conium alkaloids (such as coniine) and the pinus alkaloids. Piperine Lobeline (S)-Coniine Sedamin Solenopsin Entry on ... Alkaloids with a piperidine building block are widespread and are usually further subdivided according to their occurrence and ...
Vinca alkaloids. Class Summary. Vinca alkaloids inhibit microtubule formation, which in turn disrupts the formation of mitotic ... Vinca alkaloid derived from the periwinkle plant. Induces arrest of cell division by inhibiting microtubule formation. ...
This test is sent to an external laboratory. The panel tests for the following: Ergocornine + Ergocorninine, Ergocristine + Ergocristinine, Ergocryptine + Ergocryptinine, Ergometrine + Ergometrinine, Ergosine + Ergosinine, Ergotamine + Ergotaminine, Total Ergot. Shipping (test code: xtrnc) and handling (test code: xhand) fees are also applicable on each submission. External test price is subject to change. ...
The alkaloids represent a very diverse group of medically significant compounds that include well-known drugs like the opiates. ... Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and ... encoded search term (Tropane Alkaloid Poisoning) and Tropane Alkaloid Poisoning What to Read Next on Medscape ... Tropane Alkaloid Poisoning Differential Diagnoses. Updated: Sep 18, 2019 * Author: Richard A Wagner, MD, PhD, FACEP, FAAEM; ...
PHENOBARBITAL WITH BELLADONNA ALKALOIDS elixir. To receive this label RSS feed. Copy the URL below and paste it into your RSS ... PHENOBARBITAL WITH BELLADONNA ALKALOIDS elixir. If this SPL contains inactivated NDCs listed by the FDA initiated compliance ... Belladonna alkaloids may produce a delay in gastric emptying (antral stasis) which would complicate the management of gastric ... Phenobarbital with Belladonna Alkaloids Elixir may produce drowsiness or blurred vision. The patient should be warned, should ...
Belladonna Alkaloid Combinations and Phenobarbital: learn about side effects, dosage, special precautions, and more on ... Take belladonna alkaloid combinations and phenobarbital exactly as directed. Do not take more or less of it or take it more ... Belladonna alkaloid combinations and phenobarbital come as a regular tablet, a slow-acting tablet, capsule, and liquid to take ... Before taking belladonna alkaloid combinations and phenobarbital,. *tell your doctor and pharmacist if you are allergic to ...
... / from Progarchives.com, the ultimate progressive rock website ... Alkaloid was formed by drummer Hannes Grossmann in 2014 after leaving Obscura. In addition to Hannes Grossmann, the lineup ... Post a review of ALKALOID The Malkuth Grimoire. You must be a forum member to post a review, please register here if you are ... ALKALOID The Malkuth Grimoire ratings only. chronological order , showing rating only * rdavis1992 (Robert Davis) ...
... phenanthridine alkaloid sanguilutine was extracted and purified from the dried roots of Sanguinaria canadensis. The interaction ... Benzo[c]phenanthridine alkaloid sanguilutine was extracted and purified from the dried roots of Sanguinaria canadensis. The ... Rybáková, S., Rájecký, M., Urbanová, J. et al. Interaction of oligonucleotides with benzo[c]phenanthridine alkaloid ... Slavik, J., Dolejs, L., Hanus, V., & Cross, A. D. (1968). Alkaloids of Papaveraceae.40. chelirubine chelilutine sanguirubine ...
... and asymmetric total syntheses of four schizozygane alkaloids, which feature a ... Asymmetric Total Syntheses of Schizozygane Alkaloids. *Wenqiang Zhou. Wenqiang Zhou. Chongqing Key Laboratory of Natural ... The concise, collective, and asymmetric total syntheses of four schizozygane alkaloids, which feature a "Pan lid"-like ... Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids. Organic Letters 2022, 24 (12) , 2409-2413. https:// ...
A short survey of the history of ergot, of the original and, for a long time, only source of ergot alkaloids, is given. Once a ... Since then, worldwide investigations on ergot alkaloids resulted in the elucidation of their structures and total syntheses and ... The isolation of pharmacologically useful alkaloids started in 1906 with the discovery of ergotoxine and its adrenolytic ... activity by Barger, Can and Dale. In 1918, Stoll isolated ergotamine, the first chemically pure ergot alkaloid, which found ...
Plants with alkaloids and other poisonous plants What are poisonous plants? A poisonous plant is a plant that, when ingested or ... Plants with alkaloids and other poisonous plants. What are poisonous plants?. A poisonous plant is a plant that, when ingested ... 1 Plants with alkaloids and other poisonous plants*1.1 What are poisonous plants? ...
Pyrrolizidine alkaloids : health and safety guide  World Health Organization; International Programme on Chemical Safety (‎ ... Pyrrolizidine alkaloids / published under the joint sponsorship of the United Nations Environment Programme, the International ... World Health Organization; International Programme on Chemical Safety; WHO Task Group on Pyrrolizidine Alkaloids (‎World Health ... Safety evaluation of certain food additives and contaminants: supplement 2: pyrrolizidine alkaloids, prepared by the eightieth ...
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... alkaloids, plants & analogs by Keeper of the Trout (full text) title page ... Alkaloid content appears to be highly variable. &. Banisteriopsis inebrians+. Reported with the additional names of batahua, ... Analysis enabled the isolation of 0.37% total alkaloid; of which the bulk was harmine with the additional presence of what was ... Some of the recognized types are vegetative forms collected from the same plants; differential occurrence of alkaloids would ...
Quaternary benzo(c)phenanthridine alkaloids, new supravital DNA probes.. Name in Czech. Kvartérní benzo(c)fenantridinové ... benzo(c)phenanthridine alkaloids, cell cycle, DNA probe, flow cytometry, fluorescence microscopy, Macarpine. ... Quaternary benzo(c)phenanthridine alkaloids, new supravital DNA probes. In Sborník XIX. Biologických dnů. Hradec králové: ... benzo(c)phenanthridine alkaloids; macarpine; DNA probe; fluorescence microscopy; flow cytometry; cell cycle. ...
Psychology definition for Belladona Alkaloids in normal everyday language, edited by psychologists, professors and leading ... Belladona Alkaloids. Belladona alkaloids are nitrogenous organic compounds present in various plants such as Atropa belladona ... These alkaloids have toxic anti-cholinergic effects on both central and peripheral nervous systems, causing hallucination, ... On the other hand, such alkaloids are also being used to treat certain medical conditions such as bradycardia (abnormally slow ...
... as the above pCms were found to be contaminated with alkaloids.. Further to cases of pCms contaminated with alkaloids reported ... powder samples for the manufacturing of pCms by Kin Lam contain strychnos alkaloids and sophora alkaloids, which should not be ... "Strychnos alkaloids, existing in Chinese herbal medicines such as Semen Strychni, may cause muscle spasm and convulsion. ... Upon testing by the Government Laboratory (GL), samples of the above batch of Shi Re Qing also contained sophora alkaloids, ...
... oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, ... A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. Amy Clewell. ,1Gábor Hirka. ,2Róbert ... W.-X. Li, Y.-F. Li, Y.-J. Zhai, W.-M. Chen, H. Kurihara, and R.-R. He, "Theacrine, a purine alkaloid obtained from Camellia ... Y.-F. Li, M. Chen, C. Wang et al., "Theacrine, a purine alkaloid derived from Camellia assamica var. kucha, ameliorates ...
Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a ... 2. Alkaloids: contains 4 novel Alkaloids: Macaina 1, 2, 3, 4. 3. Bismuth: Aids in combating bacteria that causes gastritis.. 4 ... However, the root is generally richer in Alkaloids, and sells at about twice the price of the bark. Alkaloids are not the only ... Many other plants produce Alkaloids, perhaps the best known being poppy, that produces the alkaloid opium that is the precursor ...
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink ... The vinca alkaloids are also important for being cancer fighters. There are four major vinca alkaloids in clinical use: ... Sahelian R. Alkaloid substances in plants, information on vinca, ergot and ephedra alkaloid compounds. [Cited on 2011 Jul 9]; ... Vinca alkaloids Maryam Moudi 1 , Rusea Go 2 , Christina Yong Seok Yien 1 , Mohd Nazre 3 ...
... one may appreciate the cytoprotective effects of the vinca alkaloids and the genotoxic effects of the pyrrolizidine alkaloids; ... The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom. Hotti H, Rischer H. Hotti H, et al. Molecules. 2017 ... Hussain G, Rasul A, Anwar H, Aziz N, Razzaq A, Wei W, Ali M, Li J, Li X. Role of Plant Derived Alkaloids and Their Mechanism in ... Plant alkaloids represent a diverse array of secondary plant metabolites exemplified by familiar compounds such as nicotine, ...
Dixon WE The physiological action of the alkaloids derived from Anhalonium Lewinii J Physiol 1899 25(1):69-86 ... "The physiological action of the alkaloids derived from Anhalonium Lewinii" J Physiol. 1899 Sep 05;25(1):69-86. ...
Kratom alkaloids show minimal changes during the experiment, so the research pools all the observations of a series of tests to ... This alkaloid accounts for about two-thirds of the entire alkaloid content of the leaf. In comparison, 7-hydroxy mitragynine ... Fertilization of plants affecting the Kratom Alkaloids. The two main alkaloids present in the kratom are. Namely, mitragynine ... Science studies the Effects of Nutrient Fertility on Kratom Alkaloids. Cindy BB Walters August 11, 2021 Health ...
Alkaloid content and composition vary by species and growth conditions [5-7]; total alkaloid content can vary from 0.5% to 2.3 ... Ephedrine, the most potent alkaloid, can account for up to 90% of the total alkaloid content and pseudoephedrine can account ... Efficacy of ephedra and ephedra alkaloids used to enhance athletic performance. No studies assessed the effect of dietary ... Efficacy of ephedra and ephedrine alkaloids used for weight loss. RAND identified 44 controlled trials assessing ephedra and ...
Among the different alkaloids studied, neferine and berbamine were repurposed as potential drug candidates based on their ... This study is aimed at analyzing the potential of natural alkaloids, using various computational tools, as drug candidates ... and the pharmacokinetics and toxicity properties of these alkaloids were predicted using pkCSM, SwissADME, and ProTox-II ... against SARS-CoV-2. The molecular docking analysis predicted that naturally occurring alkaloids can bind with RNA-dependent RNA ...
The galbulimima alkaloids have intriguing physiological activity, but the absolute configuration of glabulimima alkaloid 13 (3 ... In situ reduction carried the liberated ketone on to the enone, which was deprotected to give glabulimima alkaloid 13 (3). Both ... Synthesis and Absolute Stereochemical Assignment of (-)-Galbulimima Alkaloid 13. ...
The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ...
Draft public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PDF/316.9 ... Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs) including ... Draft public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs) ... Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs) - First ...
Alexine is a naturally occurring pyrrolizidine alkaloid, whose isolation was reported in 1988. Considered a sugar-mimic, owing ... Total Syntheses of (+)-Alexine and Related Alkaloids. Total Syntheses of (-)-7-epi-Alexine and (+)-Alexine Using ... With these oxazolines and oxazines, we have synthesized the polyhydroxylated alkaloids containing more than three contiguous ...
... structure determination and biological evaluation of the eudistomin alkaloids, isolated mainly from marine tunicates of the ... Synthetic Approaches to the Eudistomin Marine Alkaloids. Author(s): J. McNulty and I. W.J. Still Volume 4, Issue 2, 2000 ... Keywords: Eudistomin marine alkaloids, Marine tunicates, Eudistoma, Marine natural products, Anticancer, Antibacterial, ... Keywords: Eudistomin marine alkaloids, Marine tunicates, Eudistoma, Marine natural products, Anticancer, Antibacterial, ...
  • Do your food products, ingredients and supplements conform to regulatory limits for pyrrolizidine alkaloids? (sgs.com)
  • Pyrrolizidine alkaloids (PAs) are naturally occurring toxins that can have adverse effects on human and animals, including cancer and liver damage. (sgs.com)
  • Why choose pyrrolizidine alkaloid testing services from SGS? (sgs.com)
  • However, depending on floral composition, bee pollen can be contaminated by pyrrolizidine alkaloids (PAs), PA N-oxides (PANOs) and toxigenic fungi found in plants, which may pose a potential health risk for consumers. (nih.gov)
  • Pyrrolizidine Alkaloids in Food on the Italian Market. (bvsalud.org)
  • Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by over 6000 plant species worldwide. (bvsalud.org)
  • On 1 July 2022, the Commission Regulation (EU) 2020/2040 came into force, repealed by Commission Regulation (EU) 2023/915, setting maximum levels for the sum of pyrrolizidine alkaloids in certain food . (bvsalud.org)
  • They found that grain samples gathered from household farms contained low levels of two types of plant-based liver toxins known as pyrrolizidine alkaloids (PAs). (cdc.gov)
  • Alkaloids possess significant medicinal, pharmaceutical, and ecological importance, making them a subject of extensive research by leading companies. (selfgrowth.com)
  • In this article, we will delve into the intriguing world of alkaloids, exploring their sources, structures, and attractive medicinal value. (selfgrowth.com)
  • Although most tropane alkaloids cause an anticholinergic syndrome, a case report indicates that the tropane alkaloid-containing medicinal herb Erycibe henri Prain ("Ting Kung Teng") contains a tropane alkaloid that may cause a cholinergic syndrome, as well as kidney, liver, and erythrocyte toxicity. (medscape.com)
  • Because of the medicinal use of alkaloids, proper identification is needed for safety purposes for which, a number of identification tests are available. (novapublishers.com)
  • New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed. (fu-berlin.de)
  • Piperidine alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from piperidine. (wikipedia.org)
  • In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. (selfgrowth.com)
  • Alkaloids represent a large and diverse group of organic compounds characterized by the presence of a nitrogen-containing heterocyclic ring. (selfgrowth.com)
  • Alkaloids are a fascinating group of naturally occurring chemical compounds found in various plants, fungi, and some animals. (selfgrowth.com)
  • It currently covers 21 alkaloids, including 14 compounds that co-elute, which makes individual analytical quantification impossible under current methodologies. (sgs.com)
  • The tropane alkaloids atropine, scopolamine, and hyoscyamine are highly anticholinergic compounds found in a number of plants. (medscape.com)
  • [ 1 ] The alkaloids represent a very diverse group of medically significant compounds that include well-known drugs such as the opiates. (medscape.com)
  • Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. (shabdkosh.com)
  • Some synthetic compounds of similar structure may also be termed alkaloids. (shabdkosh.com)
  • This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. (fu-berlin.de)
  • As a result, alkaloids find applications in various industries, including medicine, agriculture, and even the synthesis of fine chemicals. (selfgrowth.com)
  • Quinine, an alkaloid found in the bark of the cinchona tree, has been traditionally used as a natural remedy for malaria by interfering with the parasite's protein synthesis. (selfgrowth.com)
  • Synthesis of pyrrole and carbazole alkaloids. (novapublishers.com)
  • H. J (ed) Alkaloid synthesis. (novapublishers.com)
  • The third chapter covers the author's total synthesis of stemoamide, a 1-azabicyclo[5.3.0]decane motif containing alkaloid. (jyu.fi)
  • The term ergot alkaloid refers to a diverse group of about forty different toxins which are formed by Claviceps spp. (thebeefsite.com)
  • This fungus produces the ergot responsible for the ergot alkaloid group of mycotoxins and parasitizes the seed heads of plants at the time of flowering. (thebeefsite.com)
  • Non-ergot alkaloid with beta-blocking properties that may be effective for migraine prophylaxis. (pharmacology2000.com)
  • If you have any of these symptoms, stop taking belladonna alkaloids and phenobarbital and call your doctor immediately. (medlineplus.gov)
  • If you become pregnant while taking belladonna alkaloids and phenobarbital, call your doctor. (medlineplus.gov)
  • you should know that belladonna alkaloids may decrease sweating and cause heatstroke. (medlineplus.gov)
  • A subgroup of the alkaloids is the alkaloid amines, which include three major pharmacologic groups: the hallucinogenic alkaloid amines, the stimulant alkaloid amines, and the tropane alkaloids (also called the belladonna alkaloids or bicyclic alkaloids). (medscape.com)
  • The introduction of this thesis contains descriptions of tropane alkaloid structure and occurrence, tobacco alkaloid structure and occurrence, pharmacology of tropane alkaloids, pharmacology of tobacco alkaloids and finally, the aims of the project. (gla.ac.uk)
  • 1975. [Pharmacology of the alkaloid nitramine. (cdc.gov)
  • Recent trends in pharmacological activity of alkaloids in animal colitis: potential use for inflammatory bowel disease. (novapublishers.com)
  • Pharmacological activity of alkaloids: a review. (novapublishers.com)
  • These pharmacological features discard direct anxiolytic or analgesic actions of gelsemine through GABARs but support a role of GABARs on the alkaloid induced toxicity. (iasp-pain.org)
  • Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. (ijpsonline.com)
  • that is necessary for the production of a novel family of tetrahydropyridine alkaloids that are structural analogs of plant alkaloids. (nih.gov)
  • Thanks to exceptional affinity of plant alkaloids to various biomolecules they can be used in analytical chemistry as a probes. (muni.cz)
  • Another warning about harmala alkaloids and other MAO inhibitors. (bvsalud.org)
  • Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and pharmacologic activity. (medscape.com)
  • Metabolites were isolated based on biological activity and were characterized using tandem mass spectrometry, multidimensional nuclear magnetic resonance, and Mosher ester analysis, leading to the discovery of a new family of bacterial tetrahydropyridine alkaloids, koreenceine A to D (metabolites 1 to 4). (nih.gov)
  • Three of these metabolites are analogs of the plant alkaloid γ-coniceine. (nih.gov)
  • This work suggests that Pseudomonas and plants convergently evolved the ability to produce similar alkaloid metabolites that can mediate interbacterial competition in the rhizosphere. (nih.gov)
  • Many cultures worldwide add plants with tropane alkaloids (particularly Datura species) to alcoholic beverages to increase intoxication. (medscape.com)
  • The cereal was found to have been contaminated with tropane alkaloids from seeds of Datura stramonium that had invaded grain fields. (medscape.com)
  • The present paper reports results of the effect of Potato virus X (PVX) on the contents of total phenols and alkaloids in leaves of Datura stramonium. (scielo.br)
  • β-Phenylethylamines and the isoquinoline alkaloids. (novapublishers.com)
  • Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. (powershow.com)
  • In 2014, the CORESTA (Cooperation Centre for Scientific Research Relative to Tobacco) Routine Analytical Chemistry Sub-Group (RAC) undertook a study to compare a new, safer method of determining total alkaloids (as nicotine) in tobacco. (seal-analytical.com)
  • In addition to the total alkaloid nicotine methods, SEAL also offers many methods for tobacco analysis including the following CRMs: No.36 - Nitrate, No.37 - Reducing Substances (total sugars), and No.38 - Reducing Carbohydrates (sugars). (seal-analytical.com)
  • The biosynthesis of tropane and tobacco alkaloids has been extensively studied since the 1950's. (gla.ac.uk)
  • A critical review of the biosynthesis of the tropane and tobacco alkaloids is presented in conjunction with a simplified description of the production and manipulation of transformed root cultures. (gla.ac.uk)
  • In addition the selectivity of the enzymes involved in tropane and tobacco alkaloid biosynthesis was studied. (gla.ac.uk)
  • Serum of cattle mixed with a pilocarpine solution shows no more alkaloids present if tested directly with an alkaloidal reagent (potassium mercuric iodide) after about one hour. (aspetjournals.org)
  • Serum of rabbit which binds more pilocarpine can not be tested directly in the same way, as the reagent splits off the bound alkaloids. (aspetjournals.org)
  • The most important representative of piperidine alkaloids is piperine, which is responsible for the pungent taste of pepper. (wikipedia.org)
  • Information on the chemical and toxicological properties of individual ergot alkaloids is too limited at the present time for their selection as individual marker toxins when it comes to monitoring the extent of contamination. (thebeefsite.com)
  • Endophytic toxins in grasses include ergot alkaloids in tall fescue and tremorgens (e.g., lolitrem B) in perennial ryegrass. (thebeefsite.com)
  • These selected substances bind ergot alkaloids in the gastrointestinal tract, reduce their bioavailability and increase their excretion as an adsorbent-toxin complex, thus helping control the negative impacts of these mycotoxins. (thebeefsite.com)
  • Further classification of skin alkaloids from neotropical poison frogs (Dendrobatidae), with a general survey of toxic/noxious substances in the Amphibia. (harvard.edu)
  • The piperidine alkaloids also include the sedum alkaloids (e.g. sedamine), pelletierine, the lobelia alkaloids (e.g. lobeline), the conium alkaloids (such as coniine) and the pinus alkaloids. (wikipedia.org)
  • Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. (medscape.com)
  • Since ancient times, people have used plants containing alkaloids as remedies in the form of teas, poultices, potions, etc. to treat some diseases or sometimes as poison and dyes. (novapublishers.com)
  • It is well known that alkaloid levels in various plants can be manipulated. (shroomery.org)
  • The word or phrase alkaloids refers to natural bases containing nitrogen found in plants. (shabdkosh.com)
  • Gelsemine, one of the most abundant alkaloids in the plants, have replicated these therapeutic and toxic actions in experimental behavioral models. (iasp-pain.org)
  • Secologanin Tryptamine Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • [ 14 ] This is considered atypical for the tropane alkaloids, which are predominantly strongly anticholinergic. (medscape.com)
  • Solanaceous alkaloids cause anticholinergic symptoms including blurred vision, dry mouth, dizziness and confusion. (gov.hk)
  • In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen or sulfur. (shabdkosh.com)
  • Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • TY - JOUR T1 - Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. (unboundmedicine.com)
  • Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). (bvsalud.org)
  • Caffeine and Sodium Benzoate Injection (caffeine alkaloid ) is used along with supportive measure to treat respiratory depression associated with over dosage with CNS depressant drugs, such as narcotics. (rxlist.com)
  • Our Caffeine and Sodium Benzoate Injection (caffeine alkaloid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Caffeine and Sodium Benzoate Injection, USP (caffeine alkaloid ) is a clear, sterile, nonpyrogenic, solution of Caffeine Alkaloid. (rxlist.com)
  • Caffeine and Sodium Benzoate Injection (caffeine alkaloid) may be administered by intramuscular or slow intravenous injection Some clinicians suggest that when used as a mild CNS stimulant to overcome fatigue, oral doses of 100 200 mg of anhydrous caffeine are required. (rxlist.com)
  • Augmentation of Caffeine Alkaloids by Exogenous Indoleamines in Coffea canephora P. Ex. (asic-cafe.org)
  • Caffeine is an alkaloid that is known to have psychoactive stimulatory effects. (cdc.gov)
  • This dissertation, "The Effects of L-tetrahydropalmatine and Rhynchophylline, Alkaloids Derived From Herbal Medicines, on Cellular and Molecular Neurotoxicity of Cocaine in PC12 Cells" by Xiao, Zhang, 弹瀜, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. (google.ru)
  • Ergot alkaloids (also named ergolines) exert toxic effects in all animal species, and the most prominent toxic signs can be attributed to the interaction of ergot alkaloids with adrenergic, serotinergic and dopaminergic receptors. (thebeefsite.com)
  • Vinca alkaloids, such as vinblastine and vincristine, have also been shown to have antifungal activity. (selfgrowth.com)
  • Additionally, alkaloids like cocaine have been used as local anesthetics for surgical procedures. (selfgrowth.com)
  • The widespread distribution of alkaloids and their wide array of structures makes their classification often difficult, hence, there are different classification methods are been reported for better understanding. (novapublishers.com)
  • Herein, this work is a comprehensive revision of the web of knowledge on the introductory sight of alkaloids, their classification, extraction techniques, identification tests and pharmaceutical applications. (novapublishers.com)
  • This reagent is used as a presumptive test for narcotic alkaloids. (oherron.com)
  • In the present study, we not only investigated the therapeutic effect of the combinational treatment of Sophora moorcroftiana alkaloids and albendazole against echinococcosis in an experimental rats model, but also explored the underlying molecular mechanism of this strategy by proteomics. (hindawi.com)
  • It turns out that these locally-available and popular vegetables are rich in natural alkaloids that support the healthy function of the brain and prevent the onset of neurodegenerative diseases. (naturalnews.com)
  • Ang mga alkaloid ay ginagawa ng isang malakaing kasamu't sarian ng mga organismo, katulad ng mga bakterya , mga halamang singaw , mga halaman , at mga hayop at kabahagi ng pangkat ng mga produktong natural (tinatawag din na mga metabolite na sekundaryo ). (wikipedia.org)
  • Modulation of GABA receptors and of GABAergic synapses by the natural alkaloid gelsemine. (iasp-pain.org)
  • In conclusion, we have demonstrated that natural products, phenantridine alkaloids, can be used as alternative probes to synthetic DNA dyes such as ethidium bromide. (muni.cz)
  • Their effect on the production of the natural occurring alkaloids was examined. (gla.ac.uk)
  • The stereochemistry of discarines C ( 1 ) and D ( 2 ) and myrianthine A ( 3 ), three cyclopeptide alkaloids isolated from Discaria febrifuga , was determined by a combination of NMR studies of 1 - 3 , enantioselective gas chromatography, and comparison of NMR data with those of synthetic tripeptides. (figshare.com)
  • Alkaloids have different and dose-dependent receptor selectivity (binding affinity). (thebeefsite.com)
  • Alkaloids have demonstrated considerable potential in combatting various fungal pathogens, providing alternative treatment options for these debilitating infections. (selfgrowth.com)
  • The Department of Health (DH) is today (August 15) investigating two cases of solanaceous alkaloid poisoning after consumption of Chinese herbs. (gov.hk)
  • Another female patient, aged 63, developed similar symptoms and signs compatible with solanaceous alkaloid poisoning on August 3, including delirium and lower limb weakness about three hours after consuming a broth prepared from Chinese herbs prescribed for dyspepsia by a CMP at the Haven of Hope - The Chinese University of Hong Kong CMCTR (Sai Kung District). (gov.hk)
  • According to the Chinese medicine literature, the concerned herbs could not account for the presence of the solanaceous alkaloids detected. (gov.hk)
  • Chinese herbal medicines containing tropane alkaloids have been used to treat asthma, chronic bronchitis, pain, and flu symptoms. (medscape.com)
  • Symptoms usually occur 30-60 minutes after ingestion and may continue for 24-48 hours because tropane alkaloids delay gastric emptying and absorption. (medscape.com)
  • These alkaloids bind to specific receptors in the central nervous system, effectively alleviating severe pain and inducing sedation. (selfgrowth.com)
  • In general, many alkaloids are pharmacologically active and possess various physiological activities in humans and animals. (novapublishers.com)
  • Alkaloids with a piperidine building block are widespread and are usually further subdivided according to their occurrence and biogenetic origin. (wikipedia.org)
  • The response of luminescence intensity to low concentrations of double stranded DNA in presence of alkaloids was found to be linear and can be potentially used for quantification of DNA by means of luminescence spectrometry. (muni.cz)
  • In modern days, the biological significance of alkaloids depends on their significant relationship with health benefits. (novapublishers.com)
  • Gas chromatography/mass spectroscopy revealed amounts of scopolamine in samples submitted to all treatments, except X-I, in which the amount of this alkaloid was low. (scielo.br)
  • In order to explore the effect and mechanism of SA treatment against echinococcosis, we established animal echinococcosis model and treated rats with albendazole alone, alkaloids alone, and combined therapy. (hindawi.com)
  • On the other hand, the presynaptic effects of the alkaloid provide an additional mechanism to explain their beneficial effects. (iasp-pain.org)
  • Oram & Williams reported CPI 19305 to show variable results with total alkaloid content both higher (under controlled conditions) and lower (in field trials) than cv. (erowid.org)
  • This graph shows the total number of publications written about "Secologanin Tryptamine Alkaloids" by people in Harvard Catalyst Profiles by year, and whether "Secologanin Tryptamine Alkaloids" was a major or minor topic of these publication. (harvard.edu)
  • This means that neither the total alkaloid content, nor a single alkaloid can be recommended as reliable indicators of the potential adverse effects to livestock associated with the ingestion of ergot contaminated feeds. (thebeefsite.com)
  • Clewell A , Hirka G, Glávits R, Palmer PA , Endres JR , Murbach TS , Marx T , Pasics Szakonyiné I. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. (aibmr.com)