Scalp
Hair Follicle
Minoxidil
Dermoscopy
Hair
Mice, Inbred C3H
Autoimmune Diseases
Inosine Pranobex
Cyclobutanes
Clobetasol
Anthralin
Coal Tar
Clinical Trials, Phase I as Topic
Texas
Retrospective Studies
Contribution of interleukin 1beta and KM loci to alopecia areata. (1/140)
Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1beta single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata. (+info)Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. (2/140)
A type of hair loss closely resembling human alopecia areata has been described in C3H/HeJ mice. In order to test the assumed analogy with human alopecia areata, we investigated the efficacy of treatment with the contact allergen squaric acid dibutylester. In 12 C3H/HeJ mice with alopecia areata an allergic contact dermatitis was induced and elicited weekly on one side of the back by topical applications of squaric acid dibutylester. Overt hair regrowth was observed only on the treated side of the back in nine of 12 mice. Histopathologic examination revealed a change in the distribution of the inflammatory infiltrate from a dense perifollicular lymphocytic infiltrate around the mid and lower regions of hair follicles in untreated skin to a uniform presence in the upper dermis in treated skin. Immunohistomorphometric studies revealed that treatment with squaric acid dibutylester increased the CD4+/CD8+ ratio from approximately 1:2 in untreated alopecia areata to 1:1 in treated alopecia areata. Additional immunohistochemical investigations showed an aberrant expression of major histocompatibility complex class I, major histocompatibility complex class II and intercellular adhesion molecule 1 on keratinocytes of the mid and lower parts of hair follicles in untreated alopecia areata. In successfully treated skin ectopic major histocompatibility complex class I and II expression was clearly reduced, whereas intercellular adhesion molecule 1 expression showed only minor changes. In conclusion, alopecia areata-like hair loss in C3H/HeJ mice responded to treatment with the contact sensitizer squaric acid dibutylester analogous to human alopecia areata. Moreover, successful treatment changes the aberrant expression of major histocompatibility complex class I and II in a way similar to that observed in human alopecia areata. These observations support the concept that alopecia areata-like hair loss in C3H/HeJ mice can be utilized as an appropriate model for the study of human alopecia areata. (+info)Role of cytotoxic T cells in chronic alopecia areata. (3/140)
Cytokines play a role in alopecia areata. We used immunohistochemical and in situ hybridization studies to demonstrate the persistence of pro-inflammatory as well as apoptotic mechanisms in skin biopsies from patients with chronic alopecia areata. In situ hybridization allows the visualization of the distribution of immunocompetent cells in vivo. We studied skin biopsies from 11 untreated alopecia areata patients and two normal controls. In situ hybridization was performed on frozen sections using 35S-radio-labeled riboprobes, specific for IL-1beta, IL-2, IL-6, INFgamma, and granzyme B mRNA. Immunohistochemistry was carried out using an anti-IL-1beta monoclonal antibody, and a monoclonal antibody directed against the human Fas protein. We demonstrated the presence of cells labeled with IL-1beta, IL-6, INFgamma, and granzyme B antisense probes. Similarly, cells labeled with anti-IL-1beta were found in 10 of 11 cases. The labeled cells were located in the mononuclear peri- and intrafollicular infiltrate. Cells expressing granzyme B were found in close contact with the follicle. Fas positivity was demonstrated in four of four cases at the level of the cytoplasmic membrane of the hair follicle keratinocytes. These results, based on visualizing the labeled cells, demonstrate that pro-inflammatory cytokines are produced by the mononuclear cell infiltrate in close contact with follicles in alopecia areata. Furthermore, they demonstrate for the first time that apoptotic mechanisms involving granzyme B and Fas-Fas ligand pathways may play a major role in the persistence of chronic alopecia areata. (+info)Heavy metal poisoning in glass worker characterised by severe. (4/140)
The paper presents the clinical description of the masticatory organ and biochemical assessment of dental tissue in a patient employed in a glassworks for 20 years. During 12 years the patient has suffered baldness ("Alopecia areata") and atypical extensive and non-healing cutaneous lesions. Dental examination revealed changes typical of chronic poisoning by cadmium and bismuth compounds. (+info)Practical management of hair loss. (5/140)
OBJECTIVE: To describe an organized diagnostic approach for both nonscarring and scarring alopecias to help family physicians establish an accurate in-office diagnosis. To explain when ancillary laboratory workup is necessary to confirm the diagnosis. QUALITY OF EVIDENCE: Current diagnostic and therapeutic interventions for hair loss are based on randomized controlled studies, uncontrolled studies, and case series. MEDLINE was searched from January 1966 to December 1998 with the MeSH words alopecia, hair, and alopecia areata. Articles were selected on the basis of experimental design, with priority given to the most current large multicentre controlled studies. Overall global evidence for therapeutic intervention for hair loss is quite strong. MAIN MESSAGE: The most common forms of nonscarring alopecias are androgenic alopecia, telogen effluvium, and alopecia areata. Other disorders include trichotillomania, traction alopecia, tinea capitis, and hair shaft abnormalities. Scarring alopecia is caused by trauma, infections, discoid lupus erythematosus, or lichen planus. Key to establishing an accurate diagnosis is a detailed history, including medication use, systemic illnesses, endocrine dysfunction, hair-care practices, and family history. All hair-bearing sites should be examined. A 4-mm punch biopsy of the scalp is useful, particularly to diagnose scarring alopecias. Once a diagnosis has been established, specific therapy can be initiated. CONCLUSIONS: Diagnosis and management of hair loss is an interesting challenge for family physicians. An organized approach to recognizing characteristic differential features of hair loss disorders is key to diagnosis and management. (+info)Treatment with an anti-CD44v10-specific antibody inhibits the onset of alopecia areata in C3H/HeJ mice. (6/140)
A murine CD44v10-neutralizing antibody has been reported to impair delayed-type hypersensitivity reactions. Because alopecia areata is characterized by a delayed-type hypersensitivity-like T cell mediated immune response, we addressed the question whether an anti-CD44v10-antibody influences the onset of alopecia areata. Therefore, we used the C3H/HeJ mouse model with the induction of alopecia areata in unaffected mice by the grafting of lesional alopecia areata mouse skin. Six grafted mice were injected (intraperitoneally) with anti-CD44v10, six grafted mice with anti-CD44standard, and six with phosphate-buffered saline only. After 11 wk phosphate-buffered saline injected animals on average had developed alopecia areata on 36.8% of their body. The onset of hair loss was slightly delayed and its extent reduced to 17.2% of their body in anti-CD44standard-treated mice. By contrast, five of six anti-CD44v10-treated mice did not show any hair loss and one mouse developed alopecia areata on only 1% of the body. Immunohistochemical examination revealed a marked reduction of perifollicular CD8+ lymphocytes and, to a lesser degree, CD4+ cells as well as a decreased expression of major histocompatibility complex class I on hair follicle epithelium in anti-CD44v10-treated mice as compared with phosphate-buffered saline or anti-CD44 standard-treated mice. Our data show that anti-CD44v10 is able to inhibit the onset of alopecia areata in C3H/HeJ mice. This might be accomplished by an anti-CD44v10-triggered impairment of immune cell homing (e.g., CD8+ T cells), resulting in a decrease of their number in target tissues. (+info)Interleukin-1 receptor antagonist allele 2 and familial alopecia areata. (7/140)
Alopecia areata affects 1%-2% of the population and is hypothesized to be an autoimmune, organ specific T-cell mediated reaction directed against the human hair follicle. It is characterized by loss of hair in patches (alopecia areata) with progression in some individuals to total loss of scalp hair (alopecia totalis) or to loss of all scalp and body hair (alopecia universalis). The interleukin-1 receptor antagonist (IL-1RN) gene was found to be associated with more severe clinical outcome in several chronic inflammatory diseases, including alopecia areata. The IL-1RN*2 allele was found to be associated with alopecia areata severity in a British case-control study. In this paper, we analyzed alopecia areata probands in a family-based sample (n = 131 parent-offspring trios) to study the association between alleles of the IL-1RN and various phenotypes of alopecia areata. In considering all patients with any form of alopecia areata, no association was found with IL-1RN. IL-1RN*2 allele was not associated with alopecia totalis and alopecia universalis. A borderline association was observed between IL-1RN and patchy alopecia areata but it was not statistically significant (p =0.06). We also observed an association between IL1-RN*1 allele and patchy alopecia areata (p =0.045). (+info)Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. (8/140)
Alopecia areata is a tissue restricted autoimmune condition affecting the hair follicle, resulting in hair loss. The goal of this study was to test the hypothesis that the autoantigen of alopecia areata is melanocyte associated. Potential autoantigens were tested in the human scalp explant/Prkd(scid) CB-17 mouse transfer system. Scalp T cells from lesional (bald) alopecia areata scalp were cultured with antigen-presenting cells, and antigen, along with interleukin-2. The T cells were then injected into autologous lesional scalp grafts on SCID mice, and hair regrowth was measured. Hair follicle homogenate was used as an autoantigen control. T cells cultured with melanoma homogenate induced statistically significant reduction in hair growth (p <0.01 by ANOVA). HLA-A2-restricted melanocyte peptide epitopes were then tested with lesional scalp T cells from HLA-A2-positive alopecia areata patients. Melanocyte-peptide-activated T cells significantly reduced the number of hairs regrowing in two experiments with six patients (p <0.001 by ANOVA). Injected scalp grafts showed histologic and immunochemical changes of alopecia areata. The most consistent peptide autoantigens were the Gp100-derived G9-209 and G9-280 peptides, as well as MART-1 (27-35). Melanocyte peptide epitopes can function as autoantigens for alopecia areata. Multiple peptides were recognized, suggesting epitope spreading. (+info)Alopecia Areata is a medical condition characterized by the sudden loss of hair in round or oval patches on the scalp or other parts of the body. It is an autoimmune disorder, which means that the immune system mistakenly attacks the hair follicles, leading to hair loss. The condition can affect both adults and children, and it can cause significant emotional distress and impact a person's quality of life. In some cases, the hair may grow back on its own, while in others, treatment may be necessary to promote hair regrowth.
Alopecia is a medical term that refers to the loss of hair or baldness. It can occur in various parts of the body, but it's most commonly used to describe hair loss from the scalp. Alopecia can have several causes, including genetics, hormonal changes, medical conditions, and aging.
There are different types of alopecia, such as:
* Alopecia Areata: It is a condition that causes round patches of hair loss on the scalp or other parts of the body. The immune system attacks the hair follicles, causing the hair to fall out.
* Androgenetic Alopecia: Also known as male pattern baldness or female pattern baldness, it's a genetic condition that causes gradual hair thinning and eventual hair loss, typically following a specific pattern.
* Telogen Effluvium: It is a temporary hair loss condition caused by stress, medication, pregnancy, or other factors that can cause the hair follicles to enter a resting phase, leading to shedding and thinning of the hair.
The treatment for alopecia depends on the underlying cause. In some cases, such as with telogen effluvium, hair growth may resume without any treatment. However, other forms of alopecia may require medical intervention, including topical treatments, oral medications, or even hair transplant surgery in severe cases.
The scalp is the anatomical region located at the upper part of the human head, covering the skull except for the face and the ears. It is made up of several layers: the skin, the connective tissue, the galea aponeurotica (a strong, flat, tendinous sheet), loose areolar tissue, and the periosteum (the highly vascularized innermost layer that attaches directly to the skull bones). The scalp has a rich blood supply and is home to numerous sensory receptors, including those for touch, pain, and temperature. It also contains hair follicles, sebaceous glands, and sweat glands.
A hair follicle is a part of the human skin from which hair grows. It is a complex organ that consists of several layers, including an outer root sheath, inner root sheath, and matrix. The hair follicle is located in the dermis, the second layer of the skin, and is surrounded by sebaceous glands and erector pili muscles.
The hair growth cycle includes three phases: anagen (growth phase), catagen (transitional phase), and telogen (resting phase). During the anagen phase, cells in the matrix divide rapidly to produce new hair fibers that grow out of the follicle. The hair fiber is made up of a protein called keratin, which also makes up the outer layers of the skin and nails.
Hair follicles are important for various biological functions, including thermoregulation, sensory perception, and social communication. They also play a role in wound healing and can serve as a source of stem cells that can differentiate into other cell types.
Minoxidil is a medication that is primarily used to treat hair loss. It is a vasodilator, which means it widens blood vessels and improves blood flow. When applied to the scalp, it helps to stimulate hair growth and slows down hair loss. It is available in topical form as a solution or foam, and is usually applied once or twice a day. Minoxidil is not intended for use in children, and women who are pregnant or breastfeeding should consult with their doctor before using it.
It's important to note that minoxidil does not work for everyone, and it may take several months of regular use before any new hair growth is seen. Additionally, if the medication is discontinued, any hair gained during treatment will likely be lost over time. Common side effects of minoxidil include scalp irritation, unwanted hair growth on other parts of the body, and changes in the color or texture of existing hair. It's important to follow the instructions provided by a healthcare professional when using minoxidil.
Dermoscopy, also known as dermatoscopy or epiluminescence microscopy, is a non-invasive diagnostic technique used in dermatology to evaluate skin lesions, such as moles and pigmented skin tumors. This method involves the use of a handheld device called a dermoscope, which consists of a magnifying lens, a light source, and a transparent plate or immersion fluid that allows for better visualization of the skin's surface structures.
Dermoscopy enables dermatologists to examine the pigmented patterns, vascular structures, and other morphological features hidden beneath the skin's surface that are not visible to the naked eye. By observing these details, dermatologists can improve their ability to differentiate between benign and malignant lesions, leading to more accurate diagnoses and appropriate treatment decisions.
The primary uses of dermoscopy include:
1. Early detection and diagnosis of melanoma and other skin cancers, such as basal cell carcinoma and squamous cell carcinoma.
2. Monitoring the evolution of suspicious moles or lesions over time.
3. Assisting in the identification of various benign skin growths, like seborrheic keratoses, dermatofibromas, and nevi (moles).
4. Improving the diagnostic accuracy for infectious skin conditions, inflammatory processes, and other dermatological disorders.
Overall, dermoscopy is a valuable tool in the field of dermatology that enhances the clinician's ability to diagnose and manage various skin conditions accurately and effectively.
Medically, hair is defined as a threadlike structure that grows from the follicles found in the skin of mammals. It is primarily made up of a protein called keratin and consists of three parts: the medulla (the innermost part or core), the cortex (middle layer containing keratin filaments) and the cuticle (outer layer of overlapping scales).
Hair growth occurs in cycles, with each cycle consisting of a growth phase (anagen), a transitional phase (catagen), and a resting phase (telogen). The length of hair is determined by the duration of the anagen phase.
While hair plays a crucial role in protecting the skin from external factors like UV radiation, temperature changes, and physical damage, it also serves as an essential aspect of human aesthetics and identity.
'C3H' is the name of an inbred strain of laboratory mice that was developed at the Jackson Laboratory in Bar Harbor, Maine. The mice are characterized by their uniform genetic background and have been widely used in biomedical research for many decades.
The C3H strain is particularly notable for its susceptibility to certain types of cancer, including mammary tumors and lymphomas. It also has a high incidence of age-related macular degeneration and other eye diseases. The strain is often used in studies of immunology, genetics, and carcinogenesis.
Like all inbred strains, the C3H mice are the result of many generations of brother-sister matings, which leads to a high degree of genetic uniformity within the strain. This makes them useful for studying the effects of specific genes or environmental factors on disease susceptibility and other traits. However, it also means that they may not always be representative of the genetic diversity found in outbred populations, including humans.
Trichotillomania is defined as an irresistible urge or impulse to pull out one's hair from the scalp, eyebrows, eyelashes, or other areas of the body, resulting in noticeable hair loss. It is a mental disorder that falls under the category of obsessive-compulsive and related disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).
People with trichotillomania may experience increasing tension or anxiety before pulling their hair, and they often feel relief or pleasure after doing so. The behavior can occur during periods of stress or as a way to cope with negative emotions, but it can also happen without the individual being fully aware of it.
In addition to hair loss, trichotillomania can cause significant distress and impairment in social, occupational, or other areas of functioning. Treatment typically involves cognitive-behavioral therapy (CBT) and medication, such as selective serotonin reuptake inhibitors (SSRIs).
Autoimmune diseases are a group of disorders in which the immune system, which normally protects the body from foreign invaders like bacteria and viruses, mistakenly attacks the body's own cells and tissues. This results in inflammation and damage to various organs and tissues in the body.
In autoimmune diseases, the body produces autoantibodies that target its own proteins or cell receptors, leading to their destruction or malfunction. The exact cause of autoimmune diseases is not fully understood, but it is believed that a combination of genetic and environmental factors contribute to their development.
There are over 80 different types of autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, type 1 diabetes, Hashimoto's thyroiditis, Graves' disease, psoriasis, and inflammatory bowel disease. Symptoms can vary widely depending on the specific autoimmune disease and the organs or tissues affected. Treatment typically involves managing symptoms and suppressing the immune system to prevent further damage.
Inosine pranobex is not a medication with a widely accepted or universally recognized medical definition, as it is known by several different names and its exact mechanism of action is not completely understood. However, it is commonly referred to in medical literature as an immunomodulator, which is a substance that can modify the immune system's response to various stimuli.
Inosine pranobex is also known as Isoprinosine, and its active ingredients are inosine and p-acetamidobenzoate. It has been used off-label in some countries for the treatment of viral infections, including herpes simplex virus and influenza, although its efficacy for these indications is not well established.
Inosine pranobex is thought to work by stimulating the immune system's response to viral infections, enhancing the activity of natural killer cells and increasing the production of interferon, a protein that helps protect cells from viral infection. However, more research is needed to fully understand its mechanisms of action and potential therapeutic uses.
Cyclobutanes are a class of organic compounds that contain a four-membered carbon ring. The carbons in this ring are bonded to each other in a cyclic arrangement, forming a square-like structure. These compounds can be found naturally or synthesized in the laboratory and play important roles in various chemical reactions and biological processes.
Cyclobutanes are relatively uncommon in nature due to the strain associated with having four carbons in a small ring. This strain makes the molecules more reactive, which can lead to interesting chemical properties. For example, cyclobutanes can undergo ring-opening reactions when exposed to heat or light, leading to the formation of new chemical bonds and the release of energy.
In biology, cyclobutane rings are found in certain types of DNA damage, such as those caused by ultraviolet (UV) radiation. These damages can lead to mutations and may contribute to the development of skin cancer. However, cells have mechanisms for repairing this type of DNA damage, helping to prevent these negative outcomes.
Overall, while cyclobutanes are relatively simple molecules, they have important implications in chemistry and biology, making them a fascinating area of study.
Fluocinonide is a topical corticosteroid medication that is used to reduce inflammation and relieve itching, redness, and swelling associated with various skin conditions. It works by suppressing the immune system's response to irritation and reducing the production of inflammatory chemicals in the body. Fluocinonide is a potent steroid and is usually prescribed for short-term use only, as long-term use can lead to thinning of the skin, increased vulnerability to infection, and other side effects. It is available in various forms, including creams, ointments, and solutions, and is typically applied directly to the affected area of the skin one to three times a day.
The eyebrows are a set of hairs that grow above the eyes on the forehead. They are an important feature of human facial anatomy, and play several roles in non-verbal communication and self-expression. Eyebrows help to prevent sweat and other moisture from dripping into the eyes, and also serve as a protective barrier against dirt, dust, and other foreign particles that might otherwise irritate or damage the eyes.
In addition, eyebrows play an important role in human social interaction and communication. They can convey a range of emotions and facial expressions, such as surprise, anger, fear, happiness, and sadness. Eyebrows can also help to frame the eyes and enhance their appearance, making them an important aspect of personal grooming and beauty.
The eyebrows are made up of several components, including hair follicles, sebaceous glands, and muscles that control their movement. The hairs themselves are composed of a protein called keratin, which also makes up the hair on the head, as well as nails and skin. The color and thickness of eyebrow hair can vary widely from person to person, and may be influenced by factors such as age, genetics, and hormonal changes.
In medical terms, changes in the appearance or condition of the eyebrows can sometimes be a sign of underlying health issues. For example, thinning or loss of eyebrows can be associated with conditions such as alopecia, thyroid disorders, or nutritional deficiencies. Changes in eyebrow shape or position can also be a symptom of certain neurological conditions, such as Bell's palsy or stroke. As such, any significant changes in the appearance or condition of the eyebrows should be evaluated by a healthcare professional to rule out any underlying medical causes.
Clobetasol is a topical corticosteroid medication that is used to reduce inflammation and relieve itching, redness, and swelling associated with various skin conditions. It works by suppressing the immune system's response to reduce inflammation. Clobetasol is available in several forms, including creams, ointments, emulsions, and foams, and is usually applied to the affected area once or twice a day.
It is important to use clobetasol only as directed by a healthcare provider, as prolonged or excessive use can lead to thinning of the skin, increased susceptibility to infections, and other side effects. Additionally, it should not be used on large areas of the body or for extended periods without medical supervision.
Anthralin is a medication that is used to treat chronic plaque psoriasis. It is a synthetic form of a substance found in the bark of the araroba tree, which has been used traditionally in folk medicine to treat skin conditions. Anthralin works by slowing down the growth of skin cells, reducing inflammation, and helping to flake off scales.
Anthralin is available in various forms, including creams, ointments, and pastes, and is usually applied directly to the affected areas of the skin for a short period of time, typically ranging from 10 to 30 minutes, once or twice a day. It may take several weeks of regular use to see improvement in symptoms.
Anthralin can cause skin irritation, so it's important to follow your healthcare provider's instructions carefully when using this medication. You should also avoid applying anthralin to healthy skin and wash your hands thoroughly after each application to prevent accidentally transferring the medication to other parts of your body.
Coal tar is a thick, dark liquid that is a byproduct of coal manufacturing processes, specifically the distillation of coal at high temperatures. It is a complex mixture of hundreds of different compounds, including polycyclic aromatic hydrocarbons (PAHs), which are known to be carcinogenic.
In medical terms, coal tar has been used topically for various skin conditions such as psoriasis, eczema, and seborrheic dermatitis due to its anti-inflammatory and keratolytic properties. Coal tar can help reduce scaling, itching, and inflammation of the skin. However, its use is limited due to potential side effects such as skin irritation, increased sun sensitivity, and potential risk of cancer with long-term use. Coal tar products should be used under the guidance of a healthcare provider and according to the instructions on the label.
Phase I clinical trials are the first stage of testing a new medical treatment or intervention in human subjects. The primary goal of a Phase I trial is to evaluate the safety and tolerability of the experimental treatment, as well as to determine an appropriate dosage range. These studies typically involve a small number of healthy volunteers or patients with the condition of interest, and are designed to assess the pharmacokinetics (how the body absorbs, distributes, metabolizes, and excretes the drug) and pharmacodynamics (the biological effects of the drug on the body) of the experimental treatment. Phase I trials may also provide initial evidence of efficacy, but this is not their primary objective. Overall, the data from Phase I trials help researchers determine whether it is safe to proceed to larger-scale testing in Phase II clinical trials.
I'm not aware of any medical definition for the term "Texas." It is primarily used as the name of a state in the United States, located in the southern region. If you're referring to a specific medical term or concept that I might not be aware of, please provide more context or clarify your question.
If you meant to ask for an explanation of a medical condition named 'Texas', it is likely a typo or a misunderstanding, as there is no widely recognized medical condition associated with the name 'Texas'.
Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.
Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.
A registry in the context of medicine is a collection or database of standardized information about individuals who share a certain condition or attribute, such as a disease, treatment, exposure, or demographic group. These registries are used for various purposes, including:
* Monitoring and tracking the natural history of diseases and conditions
* Evaluating the safety and effectiveness of medical treatments and interventions
* Conducting research and generating hypotheses for further study
* Providing information to patients, clinicians, and researchers
* Informing public health policy and decision-making
Registries can be established for a wide range of purposes, including disease-specific registries (such as cancer or diabetes registries), procedure-specific registries (such as joint replacement or cardiac surgery registries), and population-based registries (such as birth defects or cancer registries). Data collected in registries may include demographic information, clinical data, laboratory results, treatment details, and outcomes.
Registries can be maintained by a variety of organizations, including hospitals, clinics, academic medical centers, professional societies, government agencies, and industry. Participation in registries is often voluntary, although some registries may require informed consent from participants. Data collected in registries are typically de-identified to protect the privacy of individuals.
Alopecia areata
Alopecia in animals
Alopecia universalis
Trichotillomania
Molly Tuttle
Rheumatoid arthritis
Hair follicle
Telogen effluvium
Squaric acid
Dibutyl squarate
Dithranol
Mark G. Lebwohl
Diphenylcyclopropenone
Relapsing polychondritis
Hypnodermatology
List of autoimmune diseases
Antonella Tosti
Alopecia totalis
Staciana Stitts
Hair loss
Janus kinase inhibitor
Gustavo Chacín
Calcipotriol
Baricitinib
Alopecia neoplastica
Renbök phenomenon
Ophiasis
Anna Kiełbasińska
Eubacterium eligens
Loose anagen syndrome
Alopecia areata - Wikipedia
Alopecia areata: MedlinePlus Genetics
Alopecia areata
Alopecia Areata: Practice Essentials, Background, Pathophysiology
JAK Inhibitors Effective for Hair Growth in Alopecia Areata
Alopecia Areata
Pfizer Begins Pivotal Study on Alopecia Areata Candidate | Nasdaq
Alopecia Areata Registry | MD Anderson Cancer Center
Most Adults With Alopecia Areata Untreated 1 Year After Dx
Alopecia Areata - Satyakaam Trigunait
![PRIME PubMed | [DNCB therapy of alopecia areata]](data:image/png;base64,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)
PRIME PubMed | [DNCB therapy of alopecia areata]
What is alopecia areata? | UCLA Health
Alopecia Areata - PAN Foundation
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity | Nature Immunology
Understanding the Profound Impact of Alopecia Areata on Patients | Article | NursingCenter
PRIME PubMed | 'Ho-ver'ing Over Alopecia Areata: Histopathological Study of 50 Cases
Lilly receives FDA approval for severe alopecia areata treatment - Inside INdiana Business
Herbal Treatment For Alopecia Areata
Development of the Alopecia Areata Patient Priority Outcomes Instrument: A Qualitative Study | Dermatology and Therapy
Slides on JAK Inhibitors for Alopecia Areata | CCO
Launceston woman shares her Alopecia Areata story | The Examiner | Launceston, TAS
drug Archives - National Alopecia Areata Foundation | NAAF
Study Archive - National Alopecia Areata Foundation | NAAF
A review of the causes of alopecia areata - keratin.com
British Library EThOS: Identification and characterisation of novel melanocyte autoantigens in alopecia areata
Raising Awareness for Alopecia Areata
Chief Family Officer: Alopecia areata
Concert Pharma (CNCE) Reports Complete Enrollment of 12mg Cohort in Phase 2a Trial of CTP-543 in Alopecia Areata
Alopecia areata - Symptoms, diagnosis and treatment | BMJ Best Practice US
National Alopecia Areata Foundation7
- The registry, sponsored by the National Alopecia Areata Foundation (NAAF), collects research samples that will help determine the genetic components of alopecia areata. (mdanderson.org)
- I am also a legislative liaison for the National Alopecia Areata Foundation, and recently completed a qualitative study about the lived experience of people with alopecia areata that revealed the extent of the trauma, loss, and physical and emotional suffering associated with the disorder. (nursingcenter.com)
- If you or someone you love has been diagnosed with alopecia in the form of alopecia areata, alopecia totalis, or alopecia universalis, please contact the National Alopecia Areata Foundation ( http://www.naaf.org ). (nursingcenter.com)
- Today marks a milestone with the first-ever FDA-approved systemic treatment for alopecia areata patients, who face significant challenges every day including limited public knowledge about the disease, a lack of treatment options and social stigma," said Nicole Friedland, president and chief executive officer of the National Alopecia Areata Foundation. (insideindianabusiness.com)
- The National Alopecia Areata Foundation is committed to delivering accurate and reliable information to everyone affected by alopecia areata, and subsequently reviews many requests for postings about participation in research studies. (naaf.org)
- RAS is an honorary member of the National Alopecia Areata Foundation (NAAF) clinical scientific advisory board. (bmj.com)
- For those of us at the National Alopecia Areata Foundation (NAAF), it was a moment - and honestly a test of our communications skills - like none before. (nationalhealthcouncil.org)
Universalis11
- In a few cases, all the hair on the scalp is lost (alopecia totalis), or all body hair is lost (alopecia universalis). (wikipedia.org)
- Uncommonly, the hair loss involves the entire scalp (in which case the condition is known as alopecia totalis) or the whole body (alopecia universalis). (medlineplus.gov)
- Patients diagnosed with either alopecia totalis or alopecia universalis were significantly less likely to receive intralesional steroids and significantly more likely to receive topical corticosteroids than those without these diagnoses (11.1% vs 44.1% and 25.4% vs 42.1, respectively). (medscape.com)
- Alopecia universalis is when hair loss also occurs on the body. (uclahealth.org)
- Current therapies are predominantly corticosteroids and immuno-modulating agents, but these are often ineffective and new targeted therapies are especially required for children, people with longterm patchy alopecia, and individuals with alopecia totalis or alopecia universalis. (bl.uk)
- There are three different kinds of hair loss: alopecia areata, alopecia totalis, and alopecia universalis. (toppik.com)
- Alopecia totalis occurs when someone loses all of his or her hair on the scalp, whereas when someone develops alopecia universalis, they lose hair on their entire body. (toppik.com)
- In other cases there can be extensive patchy hair loss and in rare cases there is total body hair loss (alopecia areata universalis), or total scalp hair loss (alopecia totalis). (bmj.com)
- This was a reaction to the frustration she experienced at how slow progress was and the apparent lack of priority given into finding effective treatment for Alopecia Totalis and Alopecia Universalis . (belgraviacentre.com)
- Its hair regrowth potential was first discovered in 2014 when the drug was administered at Yale University to a man they were treating for plaque psoriasis but who also happened to have Alopecia Universalis . (belgraviacentre.com)
- Rarely, all body hair is lost (a condition called alopecia universalis). (msdmanuals.com)
Severe10
- Note: On June 13, the U.S. Food and Drug Administration approved the drug Olumiant to treat adults with severe alopecia areata. (uclahealth.org)
- Indianapolis-based Eli Lilly and Co. (NYSE: LLY) and Incyte (Nasdaq: INCY) announced this week that the U.S. Food and Drug Administration has approved OLUMIANT as a treatment for adults with severe alopecia areata. (insideindianabusiness.com)
- The trials evaluated the efficacy and safety of OLUMIANT in 1,200 adult patients with severe alopecia areata. (insideindianabusiness.com)
- LAUSANNE , Switzerland , Nov. 21, 2023 /PRNewswire/ -- Legacy Healthcare, a clinical-stage biopharmaceutical company developing transformative medicines for the treatment of autoimmune and inflammatory diseases, continues to be featured in news outlets highlighting the company's lead drug candidate, Coacillium, for the treatment of moderate and severe alopecia areata in children and adolescents. (wwlp.com)
- Waddell says the charity's mission is to fund medical research into developing treatments for the various types of Alopecia Areata - including these more severe strains. (belgraviacentre.com)
- Last year, the U.S. Food and Drug Administration approved the use of the JAK inhibitor baricitinib to treat severe alopecia areata - but only in adults. (yale.edu)
- King noted that a young girl with severe alopecia areata recently took her own life because she was being bullied at school. (yale.edu)
- The US Food and Drug Administration (FDA) has approved Pfizer's Litfulo (ritlecitinib) for use in adolescents with severe alopecia areata, an autoimmune condition that causes hair loss. (healtheconomics.com)
- Whilst there are now options available for severe patients, there are still no approved treatments for patients with patchy disease - and yet they represent over half of the alopecia areata population and the quality-of-life impact can be devastating. (diwou.com)
- And, we'll explain the role of JAK (Janus kinase) pill medications for moderate to severe alopecia areata. (baldgirlsdolunch.org)
Patchy6
- Alopecia" is a Latin term that means baldness, and "areata" refers to the patchy nature of the hair loss that is typically seen with this condition. (medlineplus.gov)
- Patchy alopecia areata. (medscape.com)
- Alopecia areata is an autoimmune dermatologic condition that results in patchy non-scarring hair loss, usually affecting the scalp. (nasdaq.com)
- Alopecia areata is an unpredictable condition that can lead to patchy baldness or complete hair loss, says dermatologist Carolyn Goh, MD , founder of the UCLA Hair and Scalp Disorder Clinic . (uclahealth.org)
- Their aim is to develop safe and effective treatments for all forms of Alopecia Areata , the autoimmune condition which turns the body against the hair follicles, resulting in anything from patchy hair loss to total baldness from head to toe. (belgraviacentre.com)
- LONDON , Nov. 1, 2023 /PRNewswire/ - Soterios Pharma, a privately held clinical-stage pharmaceutical company, announced today that it has completed target enrolment for its Phase II trial with STS-01 for mild / moderate (patchy) alopecia areata. (diwou.com)
Cause of alopecia areata2
- A breach in this immune privilege state is considered as the cause of alopecia areata. (wikipedia.org)
- He said that genetics are the likely cause, but I got the impression that no one knows the cause of alopecia areata for sure. (chieffamilyofficer.com)
Pattern of alopecia areata2
- The inheritance pattern of alopecia areata is unclear because multiple genetic and environmental factors appear to be involved. (medlineplus.gov)
- Ophiasis pattern of alopecia areata. (medscape.com)
Adults with alopecia areata2
- Nearly three-quarters of adults with alopecia areata (AA) were not receiving treatment 1 year after diagnosis, according to a retrospective cohort study using data from more than 45,000 individuals. (medscape.com)
- Cite this: Most Adults With Alopecia Areata Untreated 1 Year After Diagnosis - Medscape - Sep 20, 2023. (medscape.com)
Public about alopecia areata1
- NAAF supports research to find a cure or acceptable treatment for alopecia areata, supports those with the disease, and educates the public about alopecia areata. (naaf.org)
Diagnose alopecia areata1
- How do dermatologists diagnose alopecia areata? (okikusuri.com)
Patients25
- Alopecia areata most often is asymptomatic, but some patients (14%) experience a burning sensation or pruritus in the affected area. (medscape.com)
- Janus kinase (JAK) inhibitors effectively stimulate hair growth, compared with placebo, for patients with alopecia areata , according to a new systematic review and meta-analysis. (medscape.com)
- The analysis encompassed seven randomized controlled trials that included 1710 patients (mean age range, 36.3 - 69.7 years) with alopecia areata. (medscape.com)
- The patients' mean baseline Severity of Alopecia Tool (SALT) scores ranged from 59.5 to 87.9. (medscape.com)
- In a recent review of the topic, Donovan emphasized that JAK inhibitors are now a first-line treatment option for patients with advanced alopecia areata. (medscape.com)
- Oral JAK inhibitors do not help all patients, and, in fact, a very large proportion of patients with advanced alopecia areata do not respond to these drugs as well as we would like," he said. (medscape.com)
- MD Anderson is leading a study to create a national registry of alopecia areata patients and their family members, to gather the necessary information for a genetic analysis. (mdanderson.org)
- Patients identified through the study will be first in line for clinical trials of any new therapies for alopecia areata. (mdanderson.org)
- MD Anderson is one of five U.S. sites registering alopecia areata patients. (mdanderson.org)
- The goal is to obtain blood samples and saliva samples from 2,500 alopecia areata patients and their families. (mdanderson.org)
- The results highlight the need to determine why so many alopecia patients with AA were no longer on treatment after 1 year, although treatment trends may change with the emergence of new therapies, such as JAK inhibitors and others, according to the authors. (medscape.com)
- Patients, family members, and loved ones of persons with alopecia areata often report emotional trauma from its impact. (nursingcenter.com)
- For example, most insurance companies do not pay for cranial prosthetics (wigs) for alopecia areata patients but will reimburse for cranial prosthetics for other disease-related hair loss such as that caused by chemotherapy. (nursingcenter.com)
- To compare the findings, in 50 patients with localized alopecia areata, 25 sectioned horizontally and 25 vertically, single section. (unboundmedicine.com)
- Although alopecia areata (AA) profoundly impacts patients' physical appearance, emotional state, and daily activities, no treatment approved for AA currently exists. (springer.com)
- Patients with alopecia areata (AA) experience profound impacts on their physical appearance, emotional state, and daily activities and face unmet treatment needs. (springer.com)
- HIV infection has been suggested as a potential trigger and there are several case reports of patients with HIV developing alopecia areata. (keratin.com)
- Further work is required to ascertain if the novel autoantibody targets are also the targets of autoreactive T lymphocytes in alopecia areata patients. (bl.uk)
- During a radio interview with Health Professional Radio Harti discusses Legacy Healthcare's positive Phase 2/3 data, filing of Coacillium for the treatment of alopecia areata, and a recent survey which found that patients would prefer prescription botanical drugs to treat their chronic diseases. (wwlp.com)
- NAAF responded to a non-stop torrent of requests from media outlets great and small both in the U.S. and abroad asking for interviews with patients, medical experts, and Foundation representatives, all wanting to know about alopecia areata and how those with the disease and their loved ones could find support and information. (nationalhealthcouncil.org)
- Joan Lunden hosted a live Facebook discussion on alopecia areata, and PBS NewsHour produced a 10-minute segment exploring the disease and how it affects patients. (nationalhealthcouncil.org)
- A medication that has been found to effectively treat the skin disease alopecia areata in adults is also successful in treating adolescent patients, according to a Yale-led clinical trial. (yale.edu)
- Because alopecia areata frequently affects children and adolescents, it is groundbreaking to advance a medicine that shows safety and effectiveness in the treatment of younger patients. (yale.edu)
- David Fleet , CEO of Soterios Pharma, said, "This represents an important milestone in the development of STS-01 as the first approved treatment for patients with mild-to-moderate alopecia areata. (diwou.com)
- Alopecia areata patients learn about skin disease treatments from their doctor, online news and education from Bald Girls Do Lunch. (baldgirlsdolunch.org)
Baldness5
- Alopecia areata, also known as spot baldness, is a condition in which hair is lost from some or all areas of the body. (wikipedia.org)
- alopecia areata is the second most common form after androgenetic alopecia (male-pattern baldness in men and female-pattern baldness in women). (medlineplus.gov)
- In others, it does not, says Dr. Goh, who has experienced baldness from alopecia areata for more than 30 years. (uclahealth.org)
- Alopecia areata is a type of hair loss that causes bald spots or complete baldness. (uclahealth.org)
- A 12-year-old girl from Indiana, Rio Allred, died by suicide last year because, according to her mother, she had been tormented and bullied at school about the baldness resulting from her alopecia areata. (nursingcenter.com)
Believed to be an autoimmune disease2
- Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles. (wikipedia.org)
- Widely believed to be an autoimmune disease, alopecia areata strikes without warning and can 'turn off' just as suddenly. (mdanderson.org)
NAAF3
- The following is a current list of clinical trials and research studies working with NAAF to recruit people with alopecia areata for particpation. (naaf.org)
- NAAF was able to work with numerous news outlets to ensure alopecia areata was featured including NPR, CNN, the Wall Street Journal, the BBC, The New York Times, The Guardian, and many local news broadcasts. (nationalhealthcouncil.org)
- Not long after the Oscar's, the first FDA- approved treatment for alopecia areata was announced - a long-fought-for goal of NAAF and our partners. (nationalhealthcouncil.org)
Affects7
- Alopecia areata most often affects the scalp and beard, but may occur on any part of the body with hair. (wikipedia.org)
- Alopecia areata affects people of all ages, although it most commonly appears in adolescence or early adulthood. (medlineplus.gov)
- Alopecia areata affects 1 in every 500 to 1,000 people in the United States. (medlineplus.gov)
- Alopecia areata affects men and women equally, and it can occur in people of any ethnic background. (medlineplus.gov)
- Although researchers have investigated the outcomes of JAK inhibitors for alopecia areata, questions remain as to whether the drugs are superior to placebo and whether the route of administration affects outcomes. (medscape.com)
- While oral JAK inhibitors are superior to topical JAK inhibitors, said Donovan, topical JAK inhibitors may have a role in the management of some aspects of alopecia areata, such as alopecia areata that affects the eyebrows and eyelashes, as well as pediatric alopecia areata. (medscape.com)
- Alopecia areata, an autoimmune disorder that causes hair loss, affects about 2% of the global population, including entertainer Jada Pinkett Smith. (uclahealth.org)
Treatment23
- Systemic corticosteroids (ie, prednisone) are not an agent of choice for alopecia areata because of the adverse effects associated with both short- and long-term treatment. (medscape.com)
- Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. (unboundmedicine.com)
- A1 - Happle,R, PY - 1979/5/15/pubmed PY - 1979/5/15/medline PY - 1979/5/15/entrez SP - 426 EP - 9 JF - Zeitschrift fur Hautkrankheiten JO - Z Hautkr VL - 54 IS - 10 N2 - Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. (unboundmedicine.com)
- Download these slides to learn about updates in the treatment landscape for alopecia areata with the recent FDA approval of JAK inhibitors and a robust development pipeline. (clinicaloptions.com)
- If you are presently under the care of a physician for alopecia areata, or other conditions, you should discuss clinical trial particpation with your doctor before altering your treatment program. (naaf.org)
- The most common treatment for alopecia areata is injections of corticosteroids into the scalp every four to six weeks. (toppik.com)
- Minoxidil treatment for alopecia areata can be taken by adults or children twice a day, and can be used on the scalp, brows, or beard. (toppik.com)
- Dr. R said that without treatment, the alopecia areata might spread. (chieffamilyofficer.com)
- Treatment of alopecia areata: An Australian expert consensus statement. (bmj.com)
- Drug Discovery & Development published the article "Legacy Healthcare aims to upend alopecia areata treatment with a botanical drug" noting that the company believes Coacillium could be a blockbuster, given its promise as a treatment for alopecia areata. (wwlp.com)
- However, this type of Alopecia Areata treatment is not available for the more extreme examples of this condition. (belgraviacentre.com)
- Indeed, clinical trials are currently going on exploring the rheumatoid arthritis drug, Xeljanz (tofacitinib), as a possible treatment for all forms of Alopecia Areata. (belgraviacentre.com)
- Other JAK inhibitors, a class of drugs originally used to treat rheumatoid arthritis and certain blood disorders, have been approved for the treatment of a host of intractable skin diseases, including alopecia areata, following more than a decade of research led by Yale dermatologist Dr. Brett King. (yale.edu)
- Concert has an extensive patent portfolio, including its lead product candidate deuruxolitinib - an oral inhibitor of Janus kinases JAK1 and JAK2 for the treatment of Alopecia Areata, an autoimmune dermatological disease - which is in late-stage development. (aap.com.au)
- There are currently limited treatment options available for Alopecia Areata. (aap.com.au)
- The acquisition of Concert adds a late-stage, potential best-in-class treatment for Alopecia Areata in deuruxolitinib," said Abhay Gandhi , CEO North America, Sun Pharma. (aap.com.au)
- Treatment for alopecia areata has come a long way in the last two decades. (baldgirlsdolunch.org)
- Interview with Kathie P. Huang, MD, author of Treatment Patterns for Alopecia Areata in the US. (ama-assn.org)
- Here's What People Are Saying About Alopecia Treatment. (okikusuri.com)
- If you have alopecia areata, your dermatologist will talk with you about how the disease is affecting your life and whether treatment is recommended. (okikusuri.com)
- What Are the Treatment Options for Alopecia Areata? (michelegreenmd.com)
- She also talks about other treatment options for Alopecia in the article, along with diet and lifestyle recommendations. (michelegreenmd.com)
- The doctor and person may choose to allow alopecia areata to resolve on its own, which sometimes happens without treatment in more mild cases. (msdmanuals.com)
Diagnosis1
- Last year at the Oscars, actress Jada Pinkett Smith, a beautiful, brave, and strong woman, sat with her family while her alopecia diagnosis was the subject of a joke by presenter Chris Rock. (nursingcenter.com)
Disease23
- In addition, alopecia areata shares genetic risk factors with other autoimmune diseases, including rheumatoid arthritis, type 1 diabetes, and celiac disease. (wikipedia.org)
- People with alopecia areata have an increased risk of developing other autoimmune disorders, including vitiligo , systemic lupus erythematosus , atopic dermatitis , allergic asthma , and autoimmune thyroid diseases (such as Hashimoto's disease and Graves' disease ). (medlineplus.gov)
- People with alopecia areata, dermatologists and other healthcare providers have been looking forward to this day when there is an FDA-approved systemic medicine for this often-devastating disease," said Dr. Brett King, associate professor of dermatology at Yale School of Medicine and lead investigator of the BRAVE-AA program. (insideindianabusiness.com)
- Alopecia areata (AA), a T-cell-mediated disease characterized by nonscarring hair loss, is one of the most common autoimmune diseases for both men and women [ 1 ]. (springer.com)
- BRAVE: Jessica Moss-Farley, 26, of Launceston was diagnosed with Alopecia Areata in November, but says she is no longer letting the disease control her life. (examiner.com.au)
- Being a rare disease, Alopecia can be very isolating. (examiner.com.au)
- Each September we recognize a very important disease known as alopecia areata. (toppik.com)
- You don't have to stop living your life because of alopecia areata , keep reading to find out what causes the disease, how to treat it, and get inspired by others who are going through a similar experience. (toppik.com)
- Alopecia areata is an autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body. (toppik.com)
- Now that you understand more about alopecia areata, the next step is identifying what can potentially cause it, and the best solutions for treating the disease. (toppik.com)
- Alopecia areata is not a strictly hereditary disease, but your risk of developing is slightly increased if you have a family member who also has the disease. (toppik.com)
- Alopecia areata is also more likely to occur in people whose family members have other autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, thyroid disease, systemic lupus erythematosus, pernicious anemia, or Addison's disease. (toppik.com)
- People who have alopecia areata are not usually at risk for developing other autoimmune diseases, but they do have a higher chance of developing thyroid disease, atopic eczema, nasal allergies, and asthma. (toppik.com)
- Alopecia areata is an autoimmune disease that targets the hair follicle. (bmj.com)
- Alopecia areata (AA) is an autoimmune disease that causes inflammation of the hair follicles resulting in nonscarring hair loss, affecting scalp and body hair. (bmj.com)
- So says Thea Chassin, founder of Bald Girls Do Lunch, a non-profit organization created for women suffering from Alopecia areata, an autoimmune skin disease which stops the normal growth of hair on the scalp, brows, lashes and body. (hairloss.com)
- We realized quickly that this was a once-in-a-lifetime opportunity to raise awareness and educate a global audience about alopecia areata, an autoimmune disease which impacts hair follicles and causes hair to fall out. (nationalhealthcouncil.org)
- Alopecia areata is an autoimmune disease characterized by sudden, often disfiguring, loss of hair. (yale.edu)
- Alopecia areata (AA) is a chronic, autoimmune disease. (karger.com)
- Alopecia Areata is an autoimmune disease in which the immune system attacks hair follicles, resulting in partial or complete loss of hair on the scalp and body. (aap.com.au)
- Dr. Christiano studies a hair loss disease called alopecia areata. (medlineplus.gov)
- Alopecia areata is a difficult disease to cope with, but there are ways for people to feel better. (medlineplus.gov)
- Alopecia Areta is a disease that causes hair loss on one or multiple body parts. (bvsalud.org)
Symptoms2
- Typical first symptoms of alopecia areata are small bald patches. (wikipedia.org)
- Following cognitive debriefing interviews, 11 items were included to form the Alopecia Areata Patient Priority Outcome (AAPPO), assessing AA-related symptoms and impacts over the past week. (springer.com)
Body's immune2
- In cases of alopecia areata, hair tends to pull out more easily along the edge of the patch where the follicles are already being attacked by the body's immune system than away from the patch where they are still healthy. (wikipedia.org)
- Many of the genes that have been associated with alopecia areata participate in the body's immune response. (medlineplus.gov)
Dermatology1
- This new work is a huge advancement for treating alopecia areata because the clinical trial involved adolescents in addition to adults," said King, an associate professor of dermatology at Yale School of Medicine and first author of the new study, which was published in The Lancet. (yale.edu)
Treatments6
- Although the safety and tolerability of JAK inhibitors were acceptable, longer randomized controlled trials are needed to further assess the effectiveness and safety of these treatments for alopecia areata," write study author Ming Liu, PhD, of McMaster University in Hamilton, Ontario, Canada, and colleagues. (medscape.com)
- There are no treatments approved by the U.S. Food and Drug Administration for alopecia. (uclahealth.org)
- By participating in a clinical trial, you play an important role in the effort to develop effective treatments for alopecia areata. (naaf.org)
- and 2) to identify and characterise novel melanocyte autoantigens using phage-display technology in order to aid a detailed understanding of the pathogenesis of alopecia areata, which is required to inform the development of new treatments. (bl.uk)
- We'll bring you the latest on the standard treatments for all types of mild alopecia areata. (baldgirlsdolunch.org)
- Other treatments for alopecia areata involve applying chemicals, such as anthralin , diphenylcyclopropenone, or squaric acid dibutylester to the scalp to induce a mild irritant reaction or mild allergic reaction, which sometimes promotes hair growth. (msdmanuals.com)
Scalp hair loss1
- All the participants, regardless of their age, had at least 50% scalp hair loss due to alopecia areata. (yale.edu)
Bald patches1
- High strength minoxidil applied topically to the signature bald patches caused by Alopecia Areata in its mild-to-moderate form has often provided promising regrowth results for Belgravia clients. (belgraviacentre.com)
Baricitinib1
- Baricitinib , one of the drugs called Janus kinase (JAK) inhibitors (which are used in treating other autoimmune and blood disorders), is useful in treating alopecia areata. (msdmanuals.com)
Ritlecitinib1
- A longer-term study of ritlecitinib to treat alopecia areata is ongoing. (yale.edu)
Congenital alopecia1
- A few cases of babies being born with congenital alopecia areata have been reported. (wikipedia.org)
Hair on the scalp1
- Alopecia totalis refers to the loss of all hair on the scalp. (uclahealth.org)
Individuals with alopecia1
- The individuals with alopecia areata are viewed as healthy except for their hair loss, but hair is an extension of the integumentary system and is essential to health, identity, and body image. (nursingcenter.com)
Systemic1
- Alopecia areata is thought to be a systemic autoimmune disorder in which the body attacks its own anagen hair follicles and suppresses or stops hair growth. (wikipedia.org)
Onset1
- Alopecia areata is when hair loss falls out in patches, and can occur in men and women of all ages, but onset often occurs in childhood. (toppik.com)
Corticosteroids1
- Alopecia areata can be treated with corticosteroids. (msdmanuals.com)
Pathogenesis1
- Endogenous retinoids metabolic defect is a key part of the pathogenesis of the alopecia areata. (wikipedia.org)
Occurs1
- Dr. R said that alopecia areata occurs when white blood cells congregate under the skin, cutting the hair off from nutrients, which results in it falling out. (chieffamilyofficer.com)
Clinical trial1
- The approval was based on Lilly's BRAVE-AA1 and BRAVE-AA2 trials, which the company says is the largest Phase 3 alopecia areata clinical trial program completed to date. (insideindianabusiness.com)
Treat alopecia1
- Topical, injection or oral steroids are often used to treat alopecia, Dr. Goh says. (uclahealth.org)
Emotional1
- Significant correlations for anxiety, depression, quality of life and illness perception levels were found, indicating relationship between alopecia areata and emotional aspects. (bvsalud.org)
Lilly1
- one author had disclosures that included receiving personal fees from Pfizer and Concert outside of the submitted study and participating in alopecia-related trials with Lilly, Concert, Aclaris, and Incyte. (medscape.com)
People11
- In most people with alopecia areata, hair falls out in small, round patches, leaving coin-sized areas of bare skin. (medlineplus.gov)
- Some of the genetic variations associated with alopecia areata have been identified in people with other autoimmune disorders, which suggests that this group of diseases may share some genetic risk factors. (medlineplus.gov)
- Similarly, people with those autoimmune disorders have an increased risk of developing alopecia areata. (medlineplus.gov)
- In many cases, it is unknown what triggers hair loss in people with alopecia areata. (medlineplus.gov)
- The purpose of the study is to create a national registry of people with alopecia areata. (mdanderson.org)
- A lopecia areata describes a form of hair loss that is unpredictable, has no cure, and may affect as many as 6.8 million people in the United States at some point in their lives. (nursingcenter.com)
- Lost in the fray was the lack of compassion routinely experienced by people living with alopecia areata. (nursingcenter.com)
- I am a nurse who has worked for decades with people who have this autoimmune disorder, and I have also watched a close family member learn to live and ultimately thrive with alopecia areata. (nursingcenter.com)
- The dismissive and mocking cruelty toward people with alopecia areata must change to active love, compassion, and support. (nursingcenter.com)
- In fact, as many as 145 million people worldwide struggle with alopecia areata, but there is hope. (toppik.com)
- Almost 300 people with alopecia have already confirmed they would be willing to donate samples, so far. (belgraviacentre.com)
Unpredictable1
- Background: Alopecia areata is an autoimmune disorder that results in unpredictable hair loss. (bl.uk)
Foundation1
- On April 29, the Australia Alopecia Areata Foundation will hold its first Tasmanian support group open day at Battery Point. (examiner.com.au)
Genetic2
- Strong evidence of genetic association with increased risk for alopecia areata was found by studying families with two or more affected members. (wikipedia.org)
- Genetic analysis of alopecia areata is only possible with a large and diverse group of participants. (mdanderson.org)
