Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Receptors, Amino Acid
Encephalitis
Dyskinesias
Teratoma
Receptors, N-Methyl-D-Aspartate
Aspartic Acid
Autoantibodies
Immunoglobulins, Intravenous
Encephalitis, Viral
Encephalitis, Japanese
Encephalitis Virus, Japanese
Chemotaxis
Aspartate Aminotransferases
Salmonella typhimurium
Chemoreceptor Cells
Limbic Encephalitis
Encephalitis, Arbovirus
Encephalitis Virus, Venezuelan Equine
Encephalitis, Herpes Simplex
Encephalitis, St. Louis
Encephalitis Viruses
Escherichia coli
Disulfides
Methylation
Encephalitis Virus, St. Louis
Aspartate Carbamoyltransferase
Japanese Encephalitis Vaccines
Encephalitis Virus, Eastern Equine
Encephalitis Virus, Western Equine
Models, Molecular
Cognitive deficits following anti-NMDA receptor encephalitis. (1/20)
(+info)Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis. (2/20)
(+info)Anti-NMDA receptor encephalitis presenting with focal non-convulsive status epilepticus in a child. (3/20)
(+info)Anti-N-methyl-D-aspartate receptor encephalitis: an emerging cause of centrally mediated sinus node dysfunction. (4/20)
(+info)Anti-N-methyl D-aspartate receptor encephalitis in childhood. (5/20)
(+info)Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease. (6/20)
(+info)Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features. (7/20)
(+info)Appearance of anti-NMDAR antibodies after plasma exchange and total removal of malignant ovarian teratoma in a patient with paraneoplastic limbic encephalopathy. (8/20)
(+info)Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a type of autoimmune encephalitis, which is a inflammation of the brain. It occurs when the body's immune system produces antibodies against NMDA receptors, which are proteins found on the surface of certain brain cells (neurons). These antibodies can bind to and disrupt the function of the NMDA receptors, leading to a range of neurological symptoms.
The symptoms of anti-NMDA receptor encephalitis typically develop over several weeks or months and can include:
* Behavioral changes, such as anxiety, agitation, or paranoia
* Memory loss
* Seizures
* Movement disorders, such as involuntary jerking or twitching of muscles
* Speech difficulties
* Loss of consciousness
* Autonomic instability (problems regulating heart rate, blood pressure, breathing and temperature)
The diagnosis is confirmed by detecting the anti-NMDA receptor antibodies in the cerebrospinal fluid (CSF) or serum. Treatment typically involves a combination of immunotherapy (such as corticosteroids, intravenous immunoglobulin, and plasma exchange) and tumor removal if a tumor is present.
It's important to note that this disorder can affect both children and adults, and it can be associated with ovarian teratoma in women of childbearing age.
Amino acid receptors are a type of cell surface receptor that bind to specific amino acids or peptides and trigger intracellular signaling pathways. These receptors play important roles in various physiological processes, including neurotransmission, hormone signaling, and regulation of metabolism.
There are several types of amino acid receptors, including:
1. G protein-coupled receptors (GPCRs): These receptors are activated by amino acids such as γ-aminobutyric acid (GABA), glycine, and glutamate, and play important roles in neurotransmission and neuromodulation.
2. Ionotropic receptors: These receptors are ligand-gated ion channels that are activated by amino acids such as glutamate and glycine. They play critical roles in synaptic transmission and neural excitability.
3. Enzyme-linked receptors: These receptors activate intracellular signaling pathways through the activation of enzymes, such as receptor tyrosine kinases (RTKs). Some amino acid receptors, such as the insulin-like growth factor 1 receptor (IGF-1R), are RTKs that play important roles in cell growth, differentiation, and metabolism.
4. Intracellular receptors: These receptors are located within the cell and bind to amino acids or peptides that have been transported into the cell. For example, the peroxisome proliferator-activated receptors (PPARs) are intracellular receptors that bind to fatty acids and play important roles in lipid metabolism and inflammation.
Overall, amino acid receptors are critical components of cell signaling pathways and play important roles in various physiological processes. Dysregulation of these receptors has been implicated in a variety of diseases, including neurological disorders, cancer, and metabolic disorders.
Encephalitis is defined as inflammation of the brain parenchyma, which is often caused by viral infections but can also be due to bacterial, fungal, or parasitic infections, autoimmune disorders, or exposure to toxins. The infection or inflammation can cause various symptoms such as headache, fever, confusion, seizures, and altered consciousness, ranging from mild symptoms to severe cases that can lead to brain damage, long-term disabilities, or even death.
The diagnosis of encephalitis typically involves a combination of clinical evaluation, imaging studies (such as MRI or CT scans), and laboratory tests (such as cerebrospinal fluid analysis). Treatment may include antiviral medications, corticosteroids, immunoglobulins, and supportive care to manage symptoms and prevent complications.
Dyskinesias are a type of movement disorder characterized by involuntary, erratic, and often repetitive muscle movements. These movements can affect any part of the body and can include twisting, writhing, or jerking motions, as well as slow, writhing contortions. Dyskinesias can be caused by a variety of factors, including certain medications (such as those used to treat Parkinson's disease), brain injury, stroke, infection, or exposure to toxins. They can also be a side effect of some medical treatments, such as radiation therapy or chemotherapy.
Dyskinesias can have a significant impact on a person's daily life, making it difficult for them to perform routine tasks and affecting their overall quality of life. Treatment for dyskinesias depends on the underlying cause and may include medication adjustments, surgery, or physical therapy. In some cases, dyskinesias may be managed with the use of assistive devices or by modifying the person's environment to make it easier for them to move around.
A teratoma is a type of germ cell tumor, which is a broad category of tumors that originate from the reproductive cells. A teratoma contains developed tissues from all three embryonic germ layers: ectoderm, mesoderm, and endoderm. This means that a teratoma can contain various types of tissue such as hair, teeth, bone, and even more complex organs like eyes, thyroid, or neural tissue.
Teratomas are usually benign (non-cancerous), but they can sometimes be malignant (cancerous) and can spread to other parts of the body. They can occur anywhere in the body, but they're most commonly found in the ovaries and testicles. When found in these areas, they are typically removed surgically.
Teratomas can also occur in other locations such as the sacrum, coccyx (tailbone), mediastinum (the area between the lungs), and pineal gland (a small gland in the brain). These types of teratomas can be more complex to treat due to their location and potential to cause damage to nearby structures.
N-Methyl-D-Aspartate (NMDA) receptors are a type of ionotropic glutamate receptor, which are found in the membranes of excitatory neurons in the central nervous system. They play a crucial role in synaptic plasticity, learning, and memory processes. NMDA receptors are ligand-gated channels that are permeable to calcium ions (Ca2+) and other cations.
NMDA receptors are composed of four subunits, which can be a combination of NR1, NR2A-D, and NR3A-B subunits. The binding of the neurotransmitter glutamate to the NR2 subunit and glycine to the NR1 subunit leads to the opening of the ion channel and the influx of Ca2+ ions.
NMDA receptors have a unique property in that they require both agonist binding and membrane depolarization for full activation, making them sensitive to changes in the electrical activity of the neuron. This property allows NMDA receptors to act as coincidence detectors, playing a critical role in synaptic plasticity and learning.
Abnormal functioning of NMDA receptors has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and chronic pain. Therefore, NMDA receptors are a common target for drug development in the treatment of these conditions.
Aspartic acid is an α-amino acid with the chemical formula HO2CCH(NH2)CO2H. It is one of the twenty standard amino acids, and it is a polar, negatively charged, and hydrophilic amino acid. In proteins, aspartic acid usually occurs in its ionized form, aspartate, which has a single negative charge.
Aspartic acid plays important roles in various biological processes, including metabolism, neurotransmitter synthesis, and energy production. It is also a key component of many enzymes and proteins, where it often contributes to the formation of ionic bonds and helps stabilize protein structure.
In addition to its role as a building block of proteins, aspartic acid is also used in the synthesis of other important biological molecules, such as nucleotides, which are the building blocks of DNA and RNA. It is also a component of the dipeptide aspartame, an artificial sweetener that is widely used in food and beverages.
Like other amino acids, aspartic acid is essential for human health, but it cannot be synthesized by the body and must be obtained through the diet. Foods that are rich in aspartic acid include meat, poultry, fish, dairy products, eggs, legumes, and some fruits and vegetables.
Autoantibodies are defined as antibodies that are produced by the immune system and target the body's own cells, tissues, or organs. These antibodies mistakenly identify certain proteins or molecules in the body as foreign invaders and attack them, leading to an autoimmune response. Autoantibodies can be found in various autoimmune diseases such as rheumatoid arthritis, lupus, and thyroiditis. The presence of autoantibodies can also be used as a diagnostic marker for certain conditions.
Intravenous Immunoglobulins (IVIG) are a preparation of antibodies, specifically immunoglobulins, that are derived from the plasma of healthy donors. They are administered intravenously to provide passive immunity and help boost the immune system's response in individuals with weakened or compromised immune systems. IVIG can be used for various medical conditions such as primary immunodeficiency disorders, secondary immunodeficiencies, autoimmune diseases, and some infectious diseases. The administration of IVIG can help prevent infections, reduce the severity and frequency of infections, and manage the symptoms of certain autoimmune disorders. It is important to note that while IVIG provides temporary immunity, it does not replace a person's own immune system.
Viral encephalitis is a medical condition characterized by inflammation of the brain caused by a viral infection. The infection can be caused by various types of viruses, such as herpes simplex virus, enteroviruses, arboviruses (transmitted through insect bites), or HIV.
The symptoms of viral encephalitis may include fever, headache, stiff neck, confusion, seizures, and altered level of consciousness. In severe cases, it can lead to brain damage, coma, or even death. The diagnosis is usually made based on clinical presentation, laboratory tests, and imaging studies such as MRI or CT scan. Treatment typically involves antiviral medications, supportive care, and management of complications.
Japanese encephalitis is a viral inflammation of the brain (encephalitis) caused by the Japanese encephalitis virus (JEV). It is transmitted to humans through the bite of infected Culex mosquitoes, particularly in rural and agricultural areas. The majority of JE cases occur in children under the age of 15. Most people infected with JEV do not develop symptoms, but some may experience mild symptoms such as fever, headache, and vomiting. In severe cases, JEV can cause high fever, neck stiffness, seizures, confusion, and coma. There is no specific treatment for Japanese encephalitis, and care is focused on managing symptoms and supporting the patient's overall health. Prevention measures include vaccination and avoiding mosquito bites in endemic areas.
Japanese Encephalitis Virus (JEV) is a type of flavivirus that is the causative agent of Japanese encephalitis, a mosquito-borne viral infection of the brain. The virus is primarily transmitted to humans through the bite of infected Culex species mosquitoes, particularly Culex tritaeniorhynchus and Culex gelidus.
JEV is endemic in many parts of Asia, including China, Japan, Korea, India, Nepal, Thailand, and Vietnam. It is estimated to cause around 68,000 clinical cases and 13,000-20,000 deaths each year. The virus is maintained in a transmission cycle between mosquitoes and vertebrate hosts, primarily pigs and wading birds.
Most JEV infections are asymptomatic or result in mild symptoms such as fever, headache, and muscle aches. However, in some cases, the infection can progress to severe encephalitis, which is characterized by inflammation of the brain, leading to neurological symptoms such as seizures, tremors, paralysis, and coma. The case fatality rate for Japanese encephalitis is estimated to be 20-30%, and around half of those who survive have significant long-term neurological sequelae.
Prevention of JEV infection includes the use of insect repellent, wearing protective clothing, and avoiding outdoor activities during peak mosquito feeding times. Vaccination is also an effective means of preventing Japanese encephalitis, and vaccines are available for travelers to endemic areas as well as for residents of those areas.
Chemotaxis is a term used in biology and medicine to describe the movement of an organism or cell towards or away from a chemical stimulus. This process plays a crucial role in various biological phenomena, including immune responses, wound healing, and the development and progression of diseases such as cancer.
In chemotaxis, cells can detect and respond to changes in the concentration of specific chemicals, known as chemoattractants or chemorepellents, in their environment. These chemicals bind to receptors on the cell surface, triggering a series of intracellular signaling events that ultimately lead to changes in the cytoskeleton and directed movement of the cell towards or away from the chemical gradient.
For example, during an immune response, white blood cells called neutrophils use chemotaxis to migrate towards sites of infection or inflammation, where they can attack and destroy invading pathogens. Similarly, cancer cells can use chemotaxis to migrate towards blood vessels and metastasize to other parts of the body.
Understanding chemotaxis is important for developing new therapies and treatments for a variety of diseases, including cancer, infectious diseases, and inflammatory disorders.
Aspartate aminotransferases (ASTs) are a group of enzymes found in various tissues throughout the body, including the heart, liver, and muscles. They play a crucial role in the metabolic process of transferring amino groups between different molecules.
In medical terms, AST is often used as a blood test to measure the level of this enzyme in the serum. Elevated levels of AST can indicate damage or injury to tissues that contain this enzyme, such as the liver or heart. For example, liver disease, including hepatitis and cirrhosis, can cause elevated AST levels due to damage to liver cells. Similarly, heart attacks can also result in increased AST levels due to damage to heart muscle tissue.
It is important to note that an AST test alone cannot diagnose a specific medical condition, but it can provide valuable information when used in conjunction with other diagnostic tests and clinical evaluation.
P-Fluorophenylalanine (p-FPA) is not a medical term, but a chemical compound used in research and medical fields. It's a type of amino acid that is used as a building block for proteins, similar to the naturally occurring amino acid phenylalanine. However, p-FPA has a fluorine atom attached to its para position (one of the possible positions on the phenyl ring).
This compound can be used in various research applications, including the study of protein synthesis and enzyme function. It's also been explored as a potential therapeutic agent for certain medical conditions, such as cancer and neurological disorders. However, more research is needed to establish its safety and efficacy for these uses.
"Salmonella enterica" serovar "Typhimurium" is a subspecies of the bacterial species Salmonella enterica, which is a gram-negative, facultatively anaerobic, rod-shaped bacterium. It is a common cause of foodborne illness in humans and animals worldwide. The bacteria can be found in a variety of sources, including contaminated food and water, raw meat, poultry, eggs, and dairy products.
The infection caused by Salmonella Typhimurium is typically self-limiting and results in gastroenteritis, which is characterized by symptoms such as diarrhea, abdominal cramps, fever, and vomiting. However, in some cases, the infection can spread to other parts of the body and cause more severe illness, particularly in young children, older adults, and people with weakened immune systems.
Salmonella Typhimurium is a major public health concern due to its ability to cause outbreaks of foodborne illness, as well as its potential to develop antibiotic resistance. Proper food handling, preparation, and storage practices can help prevent the spread of Salmonella Typhimurium and other foodborne pathogens.
Chemoreceptor cells are specialized sensory neurons that detect and respond to chemical changes in the internal or external environment. They play a crucial role in maintaining homeostasis within the body by converting chemical signals into electrical impulses, which are then transmitted to the central nervous system for further processing and response.
There are two main types of chemoreceptor cells:
1. Oxygen Chemoreceptors: These cells are located in the carotid bodies near the bifurcation of the common carotid artery and in the aortic bodies close to the aortic arch. They monitor the levels of oxygen, carbon dioxide, and pH in the blood and respond to decreases in oxygen concentration or increases in carbon dioxide and hydrogen ions (indicating acidity) by increasing their firing rate. This signals the brain to increase respiratory rate and depth, thereby restoring normal oxygen levels.
2. Taste Cells: These chemoreceptor cells are found within the taste buds of the tongue and other areas of the oral cavity. They detect specific tastes (salty, sour, sweet, bitter, and umami) by interacting with molecules from food. When a tastant binds to receptors on the surface of a taste cell, it triggers a series of intracellular signaling events that ultimately lead to the generation of an action potential. This information is then relayed to the brain, where it is interpreted as taste sensation.
In summary, chemoreceptor cells are essential for maintaining physiological balance by detecting and responding to chemical stimuli in the body. They play a critical role in regulating vital functions such as respiration and digestion.
Limbic encephalitis is a rare type of inflammatory autoimmune disorder that affects the limbic system, which is a part of the brain involved in emotions, behavior, memory, and sense of smell. It is characterized by inflammation of the limbic system, leading to symptoms such as memory loss, confusion, seizures, changes in behavior and mood, and problems with autonomic functions.
Limbic encephalitis can be caused by a variety of factors, including viral infections, cancer, or autoimmune disorders. In some cases, the cause may remain unknown. Diagnosis typically involves a combination of clinical evaluation, imaging studies (such as MRI), and analysis of cerebrospinal fluid. Treatment usually involves immunosuppressive therapy to reduce inflammation, as well as addressing any underlying causes if they can be identified.
It is important to note that limbic encephalitis is a serious condition that requires prompt medical attention and treatment. If you or someone else experiences symptoms such as sudden confusion, memory loss, or seizures, it is essential to seek medical care immediately.
Arbovirus encephalitis is a type of encephalitis (inflammation of the brain) caused by a group of viruses that are transmitted through the bite of infected arthropods, such as mosquitoes or ticks. The term "arbovirus" stands for "arthropod-borne virus."
There are many different types of arboviruses that can cause encephalitis, including:
* La Crosse virus
* St. Louis encephalitis virus
* West Nile virus
* Eastern equine encephalitis virus
* Western equine encephalitis virus
* Venezuelan equine encephalitis virus
The symptoms of arbovirus encephalitis can vary, but may include fever, headache, stiff neck, seizures, confusion, and weakness. In severe cases, it can lead to coma or death. Treatment typically involves supportive care to manage symptoms, as there is no specific antiviral treatment for most types of arbovirus encephalitis. Prevention measures include avoiding mosquito and tick bites, using insect repellent, and eliminating standing water where mosquitoes breed.
Venezuelan Equine Encephalitis Virus (VEEV) is a type of alphavirus that can cause encephalitis (inflammation of the brain) in horses and humans. It is primarily transmitted through the bite of infected mosquitoes, although it can also be spread through contact with contaminated food or water, or by aerosolization during laboratory work or in bioterrorism attacks.
VEEV infection can cause a range of symptoms in humans, from mild flu-like illness to severe encephalitis, which may result in permanent neurological damage or death. There are several subtypes of VEEV, some of which are more virulent than others. The virus is endemic in parts of Central and South America, but outbreaks can also occur in other regions, including the United States.
VEEV is considered a potential bioterrorism agent due to its ease of transmission through aerosolization and its high virulence. There are no specific treatments for VEEV infection, although supportive care can help manage symptoms. Prevention measures include avoiding mosquito bites in endemic areas, using personal protective equipment during laboratory work with the virus, and implementing strict biocontainment procedures in research settings.
Herpes simplex encephalitis (HSE) is a severe and potentially life-thingening inflammation of the brain caused by the herpes simplex virus (HSV), most commonly HSV-1. It is a rare but serious condition that can cause significant neurological damage if left untreated.
The infection typically begins in the temporal or frontal lobes of the brain and can spread to other areas, causing symptoms such as headache, fever, seizures, confusion, memory loss, and personality changes. In severe cases, it can lead to coma or death.
Diagnosis of HSE is often made through a combination of clinical presentation, imaging studies (such as MRI), and laboratory tests, including polymerase chain reaction (PCR) analysis of cerebrospinal fluid (CSF) to detect the presence of the virus.
Treatment typically involves antiviral medications, such as acyclovir, which can help reduce the severity of the infection and prevent further neurological damage. In some cases, corticosteroids may also be used to reduce inflammation in the brain. Prompt treatment is critical for improving outcomes and reducing the risk of long-term neurological complications.
St. Louis Encephalitis (SLE) is a type of viral brain inflammation caused by the St. Louis Encephalitis virus. It is transmitted to humans through the bite of infected mosquitoes, primarily Culex species. The virus breeds in warm, stagnant water and is more prevalent in rural and suburban areas.
Most people infected with SLE virus do not develop symptoms or only experience mild flu-like illness. However, some individuals, particularly the elderly, can develop severe illness characterized by sudden onset of fever, headache, neck stiffness, disorientation, coma, seizures, and spastic paralysis. There is no specific treatment for SLE, and management is focused on supportive care, including hydration, respiratory support, and prevention of secondary infections. Vaccination against SLE is not available, and prevention measures include using insect repellent, wearing protective clothing, and eliminating standing water around homes to reduce mosquito breeding sites.
Encephalitis viruses are a group of viruses that can cause encephalitis, which is an inflammation of the brain. Some of the most common encephalitis viruses include:
1. Herpes simplex virus (HSV) type 1 and 2: These viruses are best known for causing cold sores and genital herpes, but they can also cause encephalitis, particularly in newborns and individuals with weakened immune systems.
2. Varicella-zoster virus (VZV): This virus causes chickenpox and shingles, and it can also lead to encephalitis, especially in people who have had chickenpox.
3. Enteroviruses: These viruses are often responsible for summertime meningitis outbreaks and can occasionally cause encephalitis.
4. Arboviruses: These viruses are transmitted through the bites of infected mosquitoes, ticks, or other insects. Examples include West Nile virus, St. Louis encephalitis virus, Eastern equine encephalitis virus, and Western equine encephalitis virus.
5. Rabies virus: This virus is transmitted through the bite of an infected animal and can cause encephalitis in its later stages.
6. Measles virus: Although rare in developed countries due to vaccination, measles can still cause encephalitis as a complication of the infection.
7. Mumps virus: Like measles, mumps is preventable through vaccination, but it can also lead to encephalitis as a rare complication.
8. Cytomegalovirus (CMV): This virus is a member of the herpesvirus family and can cause encephalitis in people with weakened immune systems, such as those with HIV/AIDS or organ transplant recipients.
9. La Crosse virus: This arbovirus is primarily transmitted through the bites of infected eastern treehole mosquitoes and mainly affects children.
10. Powassan virus: Another arbovirus, Powassan virus is transmitted through the bites of infected black-legged ticks (also known as deer ticks) and can cause severe encephalitis.
It's important to note that many of these viruses are preventable through vaccination or by avoiding exposure to infected animals or mosquitoes. If you suspect you may have been exposed to one of these viruses, consult a healthcare professional for proper diagnosis and treatment.
'Escherichia coli' (E. coli) is a type of gram-negative, facultatively anaerobic, rod-shaped bacterium that commonly inhabits the intestinal tract of humans and warm-blooded animals. It is a member of the family Enterobacteriaceae and one of the most well-studied prokaryotic model organisms in molecular biology.
While most E. coli strains are harmless and even beneficial to their hosts, some serotypes can cause various forms of gastrointestinal and extraintestinal illnesses in humans and animals. These pathogenic strains possess virulence factors that enable them to colonize and damage host tissues, leading to diseases such as diarrhea, urinary tract infections, pneumonia, and sepsis.
E. coli is a versatile organism with remarkable genetic diversity, which allows it to adapt to various environmental niches. It can be found in water, soil, food, and various man-made environments, making it an essential indicator of fecal contamination and a common cause of foodborne illnesses. The study of E. coli has contributed significantly to our understanding of fundamental biological processes, including DNA replication, gene regulation, and protein synthesis.
Disulfides are a type of organic compound that contains a sulfur-sulfur bond. In the context of biochemistry and medicine, disulfide bonds are often found in proteins, where they play a crucial role in maintaining their three-dimensional structure and function. These bonds form when two sulfhydryl groups (-SH) on cysteine residues within a protein molecule react with each other, releasing a molecule of water and creating a disulfide bond (-S-S-) between the two cysteines. Disulfide bonds can be reduced back to sulfhydryl groups by various reducing agents, which is an important process in many biological reactions. The formation and reduction of disulfide bonds are critical for the proper folding, stability, and activity of many proteins, including those involved in various physiological processes and diseases.
Methylation, in the context of genetics and epigenetics, refers to the addition of a methyl group (CH3) to a molecule, usually to the nitrogenous base of DNA or to the side chain of amino acids in proteins. In DNA methylation, this process typically occurs at the 5-carbon position of cytosine residues that precede guanine residues (CpG sites) and is catalyzed by enzymes called DNA methyltransferases (DNMTs).
DNA methylation plays a crucial role in regulating gene expression, genomic imprinting, X-chromosome inactivation, and suppression of repetitive elements. Hypermethylation or hypomethylation of specific genes can lead to altered gene expression patterns, which have been associated with various human diseases, including cancer.
In summary, methylation is a fundamental epigenetic modification that influences genomic stability, gene regulation, and cellular function by introducing methyl groups to DNA or proteins.
St. Louis Encephalitis Virus (SLEV) is a type of arbovirus (arthropod-borne virus) from the family Flaviviridae and genus Flavivirus. It is the causative agent of St. Louis encephalitis (SLE), a viral disease characterized by inflammation of the brain (encephalitis). The virus is primarily transmitted to humans through the bite of infected mosquitoes, particularly Culex spp.
The SLEV infection in humans is often asymptomatic or may cause mild flu-like symptoms such as fever, headache, nausea, and vomiting. However, in some cases, the virus can invade the central nervous system, leading to severe neurological manifestations like meningitis, encephalitis, seizures, and even coma or death. The risk of severe disease increases in older adults and people with weakened immune systems.
There is no specific antiviral treatment for SLE; management typically focuses on supportive care to alleviate symptoms and address complications. Prevention measures include avoiding mosquito bites, using insect repellents, and eliminating breeding sites for mosquitoes. Vaccines are not available for SLEV, but they have been developed and tested in the past, with potential for future use in high-risk populations during outbreaks.
Aspartate carbamoyltransferase (ACT) is a crucial enzyme in the urea cycle, which is the biochemical pathway responsible for the elimination of excess nitrogen waste from the body. This enzyme catalyzes the second step of the urea cycle, where it facilitates the transfer of a carbamoyl group from carbamoyl phosphate to aspartic acid, forming N-acetylglutamic semialdehyde and releasing phosphate in the process.
The reaction catalyzed by aspartate carbamoyltransferase is as follows:
Carbamoyl phosphate + L-aspartate → N-acetylglutamic semialdehyde + P\_i + CO\_2
This enzyme plays a critical role in maintaining nitrogen balance and preventing the accumulation of toxic levels of ammonia in the body. Deficiencies or mutations in aspartate carbamoyltransferase can lead to serious metabolic disorders, such as citrullinemia and hyperammonemia, which can have severe neurological consequences if left untreated.
Japanese Encephalitis (JE) vaccines are immunobiological preparations used for active immunization against Japanese Encephalitis, a viral infection transmitted through the bite of infected mosquitoes. The vaccines contain inactivated or live attenuated strains of the JE virus. They work by stimulating the immune system to produce antibodies and T-cells that provide protection against the virus. There are several types of JE vaccines available, including inactivated Vero cell-derived vaccine, live attenuated SA14-14-2 vaccine, and inactivated mouse brain-derived vaccine. These vaccines have been shown to be effective in preventing JE and are recommended for use in individuals traveling to or living in areas where the disease is endemic.
Eastern equine encephalitis virus (EEEV) is a single-stranded RNA virus that belongs to the family Togaviridae and the genus Alphavirus. It is the causative agent of Eastern equine encephalitis (EEE), a rare but serious viral disease that can affect humans, horses, and some bird species.
EEEV is primarily transmitted through the bite of infected mosquitoes, particularly those belonging to the Culiseta and Coquillettidia genera. The virus is maintained in a transmission cycle between mosquitoes and wild birds, primarily passerine birds. Horses and humans are considered dead-end hosts, meaning they do not develop high enough levels of viremia to infect feeding mosquitoes and perpetuate the transmission cycle.
EEE is most commonly found in the eastern and Gulf Coast states of the United States, as well as in parts of Canada, Central and South America, and the Caribbean. The disease can cause severe neurological symptoms, including inflammation of the brain (encephalitis), meningitis, and neuritis. In severe cases, EEE can lead to seizures, coma, and death. There is no specific treatment for EEE, and prevention efforts focus on reducing mosquito populations and avoiding mosquito bites.
Cysteine is a semi-essential amino acid, which means that it can be produced by the human body under normal circumstances, but may need to be obtained from external sources in certain conditions such as illness or stress. Its chemical formula is HO2CCH(NH2)CH2SH, and it contains a sulfhydryl group (-SH), which allows it to act as a powerful antioxidant and participate in various cellular processes.
Cysteine plays important roles in protein structure and function, detoxification, and the synthesis of other molecules such as glutathione, taurine, and coenzyme A. It is also involved in wound healing, immune response, and the maintenance of healthy skin, hair, and nails.
Cysteine can be found in a variety of foods, including meat, poultry, fish, dairy products, eggs, legumes, nuts, seeds, and some grains. It is also available as a dietary supplement and can be used in the treatment of various medical conditions such as liver disease, bronchitis, and heavy metal toxicity. However, excessive intake of cysteine may have adverse effects on health, including gastrointestinal disturbances, nausea, vomiting, and headaches.
Western equine encephalitis virus (WEEV) is a type of viral encephalitis that is primarily transmitted by mosquitoes. It is caused by the western equine encephalitis virus, which belongs to the family Togaviridae and the genus Alphavirus.
WEEV is most commonly found in North America, particularly in the western and central regions of the United States and Canada. The virus is maintained in a natural cycle between mosquitoes and birds, but it can also infect horses and humans.
In humans, WEEV infection can cause mild flu-like symptoms or more severe neurological manifestations such as encephalitis, meningitis, and seizures. The virus is transmitted to humans through the bite of infected mosquitoes, particularly Culex tarsalis.
The incubation period for WEEV is typically 4-10 days, after which symptoms may appear suddenly or gradually. Mild cases of WEEV may be asymptomatic or may cause fever, headache, muscle aches, and fatigue. Severe cases may involve neck stiffness, disorientation, seizures, coma, and permanent neurological damage.
There is no specific treatment for WEEV, and management is primarily supportive. Prevention measures include the use of insect repellent, wearing long sleeves and pants, and avoiding outdoor activities during peak mosquito hours. Public health authorities may also implement mosquito control measures to reduce the risk of transmission.
Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.
Bacterial proteins can be classified into different categories based on their function, such as:
1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.
Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.
Molecular models are three-dimensional representations of molecular structures that are used in the field of molecular biology and chemistry to visualize and understand the spatial arrangement of atoms and bonds within a molecule. These models can be physical or computer-generated and allow researchers to study the shape, size, and behavior of molecules, which is crucial for understanding their function and interactions with other molecules.
Physical molecular models are often made up of balls (representing atoms) connected by rods or sticks (representing bonds). These models can be constructed manually using materials such as plastic or wooden balls and rods, or they can be created using 3D printing technology.
Computer-generated molecular models, on the other hand, are created using specialized software that allows researchers to visualize and manipulate molecular structures in three dimensions. These models can be used to simulate molecular interactions, predict molecular behavior, and design new drugs or chemicals with specific properties. Overall, molecular models play a critical role in advancing our understanding of molecular structures and their functions.
Membrane proteins are a type of protein that are embedded in the lipid bilayer of biological membranes, such as the plasma membrane of cells or the inner membrane of mitochondria. These proteins play crucial roles in various cellular processes, including:
1. Cell-cell recognition and signaling
2. Transport of molecules across the membrane (selective permeability)
3. Enzymatic reactions at the membrane surface
4. Energy transduction and conversion
5. Mechanosensation and signal transduction
Membrane proteins can be classified into two main categories: integral membrane proteins, which are permanently associated with the lipid bilayer, and peripheral membrane proteins, which are temporarily or loosely attached to the membrane surface. Integral membrane proteins can further be divided into three subcategories based on their topology:
1. Transmembrane proteins, which span the entire width of the lipid bilayer with one or more alpha-helices or beta-barrels.
2. Lipid-anchored proteins, which are covalently attached to lipids in the membrane via a glycosylphosphatidylinositol (GPI) anchor or other lipid modifications.
3. Monotopic proteins, which are partially embedded in the membrane and have one or more domains exposed to either side of the bilayer.
Membrane proteins are essential for maintaining cellular homeostasis and are targets for various therapeutic interventions, including drug development and gene therapy. However, their structural complexity and hydrophobicity make them challenging to study using traditional biochemical methods, requiring specialized techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and single-particle cryo-electron microscopy (cryo-EM).
Anti-NMDA receptor encephalitis
Paraneoplastic syndrome
Autoimmune encephalitis
Encephalitis
N-Methyl-D-aspartic acid
Inflammatory demyelinating diseases of the central nervous system
Limbic encephalitis
Multiple sclerosis research
Meningoencephalitis
Anti-glutamate receptor antibodies
Postpartum psychosis
Teratoma
Herpes simplex encephalitis
Risk factors of schizophrenia
Astrocyte
Quinolinic acid
NMDA receptor
Hippocampus
Schizophrenia
Frontiers | Anti-N-methyl-D-Aspartate Receptor Encephalitis Mimicking Sporadic Creutzfeldt-Jakob Disease
Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia: A case report
Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease...
N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica
Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations. A Report of...
Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent...
Anti-N-methyl-D-aspartate-receptor encephalitis: cognitive profile in two children. - Immunology
Forty-five years of split-brain research and still going strong | Nature Reviews Neuroscience
Anti-N-methyl-D-aspartate receptor encephalitis: a newly recognized inflammatory brain disease in children | Pediatric...
Solitary juxtacortical lesion associated with anti-N-methyl-D-aspartate receptor encephalitis: a case report | BMC Neurology |...
Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations: A Report of...
Anti-NMDA receptor encephalitis - Wikipedia
Acute Disseminated Encephalomyelitis Differential Diagnoses
Acute Disseminated Encephalomyelitis: Background, Pathophysiology, Epidemiology
"Front Hum Neurosci"[journal] - PMC -...
Franciotta D[au] - Search Results - PubMed
Medical Science Monitor | Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and...
Acute Disseminated Encephalomyelitis: Background, Pathophysiology, Epidemiology
UKE - Physician - Jessika Johannsen
EEG in Dementia and Encephalopathy: Overview, Dementia, Vascular Dementia
Encephalitis - Neurologic Disorders - Merck Manuals Professional Edition
EB Medicine - Browse Topics by CME Category or Product
Encephalitis - Encephalitis, Rasmussen Summary Report | CureHunter
The Challenge of Diagnosing Encephalitis | myADLM.org
Paraneoplastic Autonomic Neuropathy: Background, Pathophysiology, Epidemiology
Seizure Disorders - Neurologic Disorders - MSD Manual Professional Edition
School of Psychology - Research Outputs - Aston Research Explorer
Publikationen
Publications
Antibodies15
- Recent studies reported that some patients confirmed to have sCJD had low levels of serum antibodies to NMDAR, glycine receptor, and voltage-gated potassium channel (VGKC) complex ( 2 - 4 ). (frontiersin.org)
- Background Patients with encephalitis associated with antibodies against N-methyl-D-aspartate-receptor antibody (NMDAR-ab) encephalitis frequently show psychotic symptoms, amnesia, seizures and movement disorders. (bmj.com)
- BACKGROUND: Anti-N-Methyl D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder associated with antibodies against NMDAR resulting in a characteristic neuropsychiatric syndrome characterized by seizures, dyskinesias, and cognitive impairment. (ox.ac.uk)
- Four children (22%) had positive anti-NMDAR antibodies and were diagnosed with anti-NMDAR encephalitis. (biomedcentral.com)
- Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a severe autoimmune encephalitis mediated by anti-NMDA receptor antibodies. (biomedcentral.com)
- A full panel of antibodies for autoimmune encephalitis is the key leading to the diagnosis. (biomedcentral.com)
- Anti-NMDA receptor encephalitis is a type of brain inflammation caused by antibodies. (wikipedia.org)
- Whilst the exact pathophysiology of the disease is still debated, empirical evaluation of the origin of anti-NMDA receptor antibodies in serum and cerebrospinal fluid leads to the consideration of two possible mechanisms. (wikipedia.org)
- Serum NMDA receptor antibodies are consistently found at higher concentrations than cerebrospinal fluid antibodies, on average ten times higher. (wikipedia.org)
- This implies that there are more NMDA receptor antibodies in the cerebrospinal fluid than would be predicted given the expected quantities of total IgG. (wikipedia.org)
- Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. (ocu-radiology.jp)
- Believed to treat conditions associated with inflammation and immune dysregulation by neutralizing circulating myelin antibodies through anti-idiotypic antibodies. (medscape.com)
- 7 Twenty-three patients were enrolled, including cases with anti-Mi2 autoantibodies and excluding those with antisynthetase antibodies or necrotizing myopathy and signal recognition particle antibodies. (neurology.org)
- Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness. (upf.edu)
- A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). (upf.edu)
NMDA18
- In very rare instances, anti-NMDA receptor encephalitis can present with a solitary brain lesion. (biomedcentral.com)
- Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was first described by Dalmau, et al. (biomedcentral.com)
- We herein report a case of anti-NMDA receptor encephalitis initially presenting with focal seizures and. (biomedcentral.com)
- Prior to the development of a symptom complex that is specific to anti-NMDA receptor encephalitis, people may experience prodromal symptoms, including headaches, flu-like illness, or symptoms similar to an upper respiratory infection. (wikipedia.org)
- citation needed] One distinguishing characteristic of anti-NMDA receptor encephalitis is the concurrent presence of many of the above listed symptoms. (wikipedia.org)
- The condition is mediated by autoantibodies that target NMDA receptors in the brain. (wikipedia.org)
- These can be produced by cross reactivity with NMDA receptors in teratomas, which contain many cell types, including brain cells, and thus present a window in which a breakdown in immunological tolerance can occur. (wikipedia.org)
- N-Methyl-D-Aspartate(NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis. (bvsalud.org)
- Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have anti- N-methyl-D-aspartate ( NMDA ) receptor or anti- voltage-gated potassium channel (VGKC) encephalitis . (bvsalud.org)
- Four (26.7%) patients were diagnosed with anti-NMDA receptor encephalitis and 1 (6.7%) with anti-VGKC encephalitis . (bvsalud.org)
- Advances in defining clinical criteria and immunologic biomarkers of autoimmune diseases such as MS or autoimmune encephalitides coupled with conventional MRI studies and diffusion tensor imaging (DTI) have revealed overlapping diseases characterized by autoantibodies against neuronal or glial surface proteins (NMDA receptor, aquaporin 4, or myelin oligodendrocyte glycoprotein) 1 , 2 and may disclose in the future unclassified autoimmune disorders with yet unknown mechanisms. (neurology.org)
- An example is anti-NMDA receptor encephalitis, where patients with severe symptoms often have normal conventional MRI studies, but DTI reveals extensive white matter abnormalities with decreased fractional anisotropy. (neurology.org)
- Since its first description in 2007, anti N-methyl Daspartate (NMDA) receptor encephalitis is an increasingly identified cause for autoimmune/paraneoplastic encephalitis [ 2 ]. (imedpub.com)
- NMDA receptor encephalitis is responsive to immunotherapy (IVIG, Steroids, Plasma exchange and anti-CD20 antibody, Rituximab), if initiated early in its clinical course, and surgery as indicated for teratomas. (imedpub.com)
- We had previously reported a patient in minimally conscious state secondary to NMDA receptor, who after immunotherapy and tumor removal, had responded temporally to Zolpidem and would act appropriately as long as the medication lasts [ 3 ]. (imedpub.com)
- Based on the clinical experience, we had suggested use of Zolpidem as an adjunct to immunotherapy in patients with anti NMDA receptor encephalitis. (imedpub.com)
- In patients with NMDA encephalitis, Zolpidem may be a reasonable adjunct therapy after initial immunotherapy. (imedpub.com)
- 2012) Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. (imedpub.com)
NMDAR26
- Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt-Jakob disease (sCJD) share similar clinical features. (frontiersin.org)
- Here, we present two unusual cases of anti-NMDAR encephalitis who were misdiagnosed as sCJD at first. (frontiersin.org)
- Anti-NMDAR encephalitis can present with rapidly progressive cognitive decline, and sometimes laboratory investigations can be misleading. (frontiersin.org)
- Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and sporadic Creutzfeldt-Jakob disease (sCJD) share a lot of similar clinical features, such as prominent cognitive decline, memory problems, psychiatric symptoms, and movement disorders ( 1 ). (frontiersin.org)
- Furthermore, the follow-up findings confirmed the diagnosis of anti-NMDAR encephalitis. (frontiersin.org)
- While brain MRI in NMDAR-ab encephalitis is often normal, abnormalities of cerebral glucose metabolism have been demonstrated by positron emission tomography (PET) with 18F-fluorodeoxyglucose(FDG) in a few usually isolated case reports. (bmj.com)
- Methods The authors retrospectively identified six patients with NMDAR-ab encephalitis in two large German centres who underwent at least one whole-body FDG-PET for tumour screening between January 2007 and July 2010. (bmj.com)
- Results Groupwise analysis revealed that patients with NMDAR-ab encephalitis showed relative frontal and temporal glucose hypermetabolism associated with occipital hypometabolism. (bmj.com)
- Conclusions A characteristic change in cerebral glucose metabolism during NMDAR-ab encephalitis is an increased frontotemporal-to-occipital gradient. (bmj.com)
- EL shares clinical features with the anti-N-methyl-D-aspartate receptor (NMDAR-Ab) encephalitis. (nih.gov)
- The dyskinetic form of EL is an NMDAR-Ab encephalitis and can affect very young children. (nih.gov)
- The extent and specific tasks associated with cognitive dysfunction in anti-NMDAR encephalitis have not been fully investigated. (ox.ac.uk)
- AIMS: To describe cognitive and neuropsychological profile in two children with anti-NMDAR encephalitis. (ox.ac.uk)
- CONCLUSIONS: Executive dysfunction seems to be the "core" of the neuropsychological profile of children with anti-NMDAR encephalitis. (ox.ac.uk)
- The aim of this study was to report characteristic clinical features and outcomes of children diagnosed with Anti- N -methyl-D-aspartate receptor (NMDAR) encephalitis, a newly recognized anti-neuronal antibody-mediated inflammatory brain disease, seen by the Rheumatology service over an 18 month period. (biomedcentral.com)
- Over an 18-month period (July 2009-Dec 2010), consecutive children presenting with newly acquired psychiatric and/or neurologic deficits consistent with anti-NMDAR encephalitis and evidence of central nervous system (CNS) inflammation were screened. (biomedcentral.com)
- Serum and cerebrospinal fluid (CSF) samples were obtained and sent for anti-NMDAR antibody testing. (biomedcentral.com)
- Over the study period a total of 18 children presented with clinical features compatible with anti-NMDAR encephalitis including psychiatric manifestations, seizures and/or movement disorders. (biomedcentral.com)
- All children with anti-NMDAR encephalitis presented with neuropsychiatric deficits including, seizures, speech disorder, sleep disturbance, and fluctuating level of consciousness. (biomedcentral.com)
- Anti-NMDAR encephalitis is an important, reversible cause of neuropsychiatric deficits in children that must be included in the differential diagnosis of CNS vasculitis and other inflammatory brain diseases. (biomedcentral.com)
- NMDAR) encephalitis was diagnosed by on-cell Western ncephalitis is a serious infection causing high rates analysis ( 6 ). (cdc.gov)
- The underlying mechanism is autoimmune, with the primary target being the GluN1 subunit of the N-methyl D-aspartate receptors (NMDAR) in the brain. (wikipedia.org)
- Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. (upf.edu)
- The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. (upf.edu)
- An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. (upf.edu)
- Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD. (upf.edu)
California Encephalitis Project2
- Glaser is chief of the Encephalitis and Special Investigations Section of the California Department of Public Health (CDPH) and former principal investigator of the California Encephalitis Project, a partnership between CDPH and the U.S. Centers for Disease Control and Prevention (CDC). (aacc.org)
- Gable MS, Sheriff H, Dalmau J, Tilley DH, Glaser CA (2012) The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. (imedpub.com)
Neurologic1
- Anti-IgLON5 IgG-associated neurologic disorder. (ocu-radiology.jp)
Paraneoplastic1
- 2007) Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. (imedpub.com)
Clin Infect Dis1
- In response, the International Encephalitis Consortium (IEC), a multidisciplinary committee begun in 2010, recently issued a comprehensive guideline, which proposes standard definitions and a diagnostic algorithm for evaluating both children and adults with suspected encephalitis worldwide (Clin Infect Dis 2013;57:1114-28). (aacc.org)
Limbic encephalitis1
- also reported that some patients with a diagnosis of immunotherapy-responsive limbic encephalitis had their treatment delayed because of a suspected diagnosis of sCJD ( 7 ). (frontiersin.org)
Neurology2
- We anticipate that this algorithm can lead to rational, as opposed to shotgun, testing in cases of suspected encephalitis," said the guideline's first author, Arun Venkatesan, MD, PhD, assistant professor of neurology and director of the Encephalitis Center at Johns Hopkins University in Baltimore. (aacc.org)
- Autoimmune encephalitis is an increasingly identified area for practitioners in Neurology , Child Neurology and Psychiatry . (imedpub.com)
Hashimoto's1
- Conversely, some researchers have found that some forms of autoimmune encephalitis could be misdiagnosed as CJD, including Hashimoto's and VGKC complex antibody-associated encephalopathies ( 5 , 6 ). (frontiersin.org)
Viral5
- Encephalitis is inflammation of the parenchyma of the brain, resulting from direct viral invasion or occurring as a postinfectious immunologic complication caused by a hypersensitivity reaction to a virus or another foreign protein. (merckmanuals.com)
- Encephalitis can also occur as a late reactivation of latent or subclinical viral infection. (merckmanuals.com)
- Encephalitis can occur as a secondary immunologic complication of certain viral infections or vaccinations. (merckmanuals.com)
- Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition. (curehunter.com)
- Though encephalitis still is rare, its incidence both in the United States and internationally is increasing along with a rise in viral diseases like herpes, West Nile disease, Japanese encephalitis virus, and tick-borne encephalitis virus, among other causes. (aacc.org)
Severe1
- Common severe infections include encephalitis. (merckmanuals.com)
Inflammation2
- The prominence of perivenular round cell inflammation in either illness is a feature that is shared with many forms of encephalitis, but patchy demyelination with preservation of axon cylinders and the prominence of microglial cells in the inflammatory exudate are not. (medscape.com)
- Chronic environmental stress is known to induce inflammation in the brain, which is closely related to psychiatric or psychosocial behaviors shown in brain disorders such as schizophrenia, dementia, encephalitis, autism, and psychopathy [ 1 - 27 ]. (encephalitisjournal.org)
Symptoms1
- The algorithm in question lists routine studies and tests that should be performed on all suspected encephalitis patients, as well as conditional studies based on host and geographic factors, season and exposure, specific signs and symptoms, and both laboratory and neuroimaging features (See chart, p. 4). (aacc.org)
Infectious3
- Glaser, who worked on previous encephalitis guidelines issued by the Infectious Diseases Society of America, noted that they were also quite comprehensive, but "were too unwieldy to use at the bedside. (aacc.org)
- This stratified approach of performing a clutch of routine tests plus conditional studies-based on patient-specific circumstances-is a pragmatic approach to the diagnostic work-up of encephalitis, given that many of the recommended tests use precious cerebral spinal fluid (CSF), said James Sejvar, MD, a neuroepidemiologist in the Division of High Consequence Pathogens and Pathology at CDC's National Center for Emerging and Zoonotic Infectious Diseases in Atlanta. (aacc.org)
- the first and second are infectious encephalitis and acute disseminated encephalomyelitis. (researchsquare.com)
Brain3
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection. (ox.ac.uk)
- We report a 3-year-old boy with anti-N-methyl-D-aspartate receptor encephalitis with a typical syndrome of movement disorder and encephalopathy and evidence of herpes simplex virus (HSV) type 1 infection on brain biopsy. (ox.ac.uk)
- Viruses causing primary encephalitis directly invade the brain. (merckmanuals.com)
Herpes2
- Treatment involves antiviral drugs when indicated (eg, in herpes simplex virus encephalitis) and is otherwise supportive. (merckmanuals.com)
- Encephalitis is most commonly due to viruses, such as herpes simplex, herpes zoster, cytomegalovirus. (merckmanuals.com)
Psychiatric3
- Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. (nih.gov)
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations. (ox.ac.uk)
- Patients with autoimmune encephalitis also tended to be more unwell, with the majority requiring intensive care , had lower global assessment of functioning scores (30 ± 10 vs. 53.7 ± 21.2, p = 0.09), and were not well enough to complete standard psychiatric and cognitive assessments at presentation. (bvsalud.org)
Cognitive1
- Anti-N-methyl-D-aspartate-receptor encephalitis: cognitive profile in two children. (ox.ac.uk)
Subunit1
- Zolpidem is an non benzodiazepine imidazopyridine compound that selectively binds to alpha-1 subunit of GABA- A receptor resulting in release of inhibitory neurotransmitter gamma amino butyric acid (GABA). (imedpub.com)
Disorders1
- Appu M, Noetzel M (2014) Clinically significant response to zolpidem in disorders of consciousness secondary to anti-N-methyl-D-aspartate receptor encephalitis in a teenager: a case report. (imedpub.com)
Prodromal1
- HSV type 1 infection and anti-N-methyl-D-aspartate receptor encephalitis are temporally linked in some cases: this case suggests that prodromal HSV type-1 infection may be clinically subtle and easily missed. (ox.ac.uk)
Adults1
- The phylogenetic analysis was done with a neighbor- possible pathogens in children and adults with encephalitis joining tree by using MEGA5 (www.megasoftware.net). (cdc.gov)
Diagnosis1
- Mitra AD, Afify A. Ovarian teratoma associated Anti-N-methyl-D-aspartate receptor encephalitis: a difficult diagnosis with a favorable prognosis. (ucdavis.edu)
Needed to characterize1
- 5 Further studies are needed to characterize this category of MRI-negative autoimmune encephalitis, which perhaps in the future may be defined by yet unknown immunologic biomarkers. (neurology.org)
Acute2
- Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. (bvsalud.org)
- Autoimmune encephalitis is not uncommon in patients with acute psychosis . (bvsalud.org)
Consequence1
- As a consequence, the process of diagnosing encephalitis is highly variable among clinicians and institutions, and fraught with inappropriate testing. (aacc.org)
Cases3
- Globally, the Nucleotide sequences of all amplicons were deter- causes remain unrecognized in 60%-85% of encephalitis mined to confirm the PCR products, to distinguish geno- cases ( 1 , 2 ). (cdc.gov)
- Another established trigger is herpesviral encephalitis, while the cause in others cases is unclear. (wikipedia.org)
- remains a significant cause of encephalitis in developing countries and still causes a few cases of encephalitis in the US. (merckmanuals.com)
Children2
- BLAST implicated in causing life-threatening encephalitis in Ban- analysis (www.ncbi.nlm.nih.gov/blast) was used to identi- gladeshi children ( 3 ). (cdc.gov)
- To explore the immune characteristics and short-term prognosis of children with autoimmune encephalitis (AE), then to analyse the relationship between them. (researchsquare.com)
Equivalent1
- The usual approach is administration of methylprednisolone for 3-5 d IV (or the equivalent dose of some other anti-inflammatory corticosteroid). (medscape.com)
Case report1
- Wang CC, Li DJ, Xia YQ, Liu K. Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia: A case report. (wjgnet.com)
Therapy4
- HHV-6 encephalitis associated with CD19-directed CAR-T therapy. (ocu-radiology.jp)
- Chimeric antigen receptor (CAR) T-cell therapy is effective in relapsed/refractory large B-cell lymphoma and results in a unique toxicity profile, namely cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome. (chemnews-japan.com)
- Tanguturi YC, Cundiff AW, Fuchs C. Anti-N-Methyl d-Aspartate Receptor Encephalitis and Electroconvulsive Therapy: Literature Review and Future Directions. (ucdenver.edu)
- Use of dexmedetomidine as adjunctive therapy for anti-N-methyl-D-aspartate receptor encephalitis. (uci.edu)