Ardisia
Ardisiphenols and other antioxidant principles from the fruits of Ardisia colorata. (1/9)
Novel alkylphenols, ardisiphenols A-C (1-3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4-6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13), quercetin-3-O-beta-D-glucopyranoside (14) and gallic acid (15). Their structures were determined by NMR, MS(/MS) analyses and other spectroscopic methods. Ardisiphenols showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and showed cytotoxicity against the murine breast cancer cell line, FM3A. (+info)Ardisimamillosides G and H, two new triterpenoid saponins from Ardisia mamillata. (2/9)
Two new triterpenoid saponins, ardisimamilloside G (1), 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucop yranosyl-(1-->2)]-alpha-L-arabinopyranosyl]-13beta,28-epoxy-16-oxo-oleanan-3beta, 30-diol and ardisimamilloside H (2), 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->4)-alpha-L-arabin opyranosyl]-3beta-hydroxy-13beta,28-epoxy-16-oxo-oleanan-30-al, were isolated from the roots of Ardisia mamillata HANCE. Structure assignments were established on the basis of spectral data and chemical evidence. (+info)Triterpenoid saponins from Ardisia gigantifolia. (3/9)
Four new triterpenoid saponins (1-4) were isolated from the rhizome of Ardisia gigantifolia STAPF. The structures of new saponins were established as 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glu copyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16al pha-hydroxy-13,28-epoxy-oleanane (1), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glu copyranosyl-(1-->4)-[beta-D-glucopyrano-syl-(1-->2)]-alpha-L-arabinopyranosyl-16a lpha-hydroxy-13,28-epoxy-30-acetoxy-oleanane (2), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->4)-beta-D-xyl opyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)] -alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (3) and 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glu copyranosyl-(1-->4)-[beta-D-6-O-acetylglucopranosyl-(1-->2)]-alpha-L-arabinopyran osyl-16alpha-hydroxy-13,28-epoxy-oleanane (4) were isolated from Ardisia gigantifolia STAPF. Their structures were elucidated by means of (1)H- and (13)C-NMR spectroscopic studies, including 2D-NMR technique. The cytotoxic activities of saponins 1-4 are reported against three human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, and BCG-823 human gastric carcinoma cells. (+info)Suppression of DMBA/croton oil-induced mouse skin tumor promotion by Ardisia Crispa root hexane extract. (4/9)
Ardisia crispa (Family: Myrsinaceae) has been used as a traditional medicine for various ailments. Previous studies showed that Ardisia crispa possesses antimetastatic and anti-inflammatory properties. Nevertheless, research done on the plant is still limited. Therefore, the present study was designed to evaluate the suppression effect of Ardisia crispa root hexane (ACRH) extract on 7, 12-dimethylbenz (alpha) anthracene (DMBA)-induced mice skin tumor promotion in ICR mice with topical application twice weekly for 10 weeks. Results showed significant difference between treatment groups (mice treated with 30 mg/kg, 100 mg/kg and 300 mg/kg of ACRH extract; denoted as group I, II and III respectively) for tumor incidence and tumor burden (P<0.05). Significant reduction in tumor incidence (20%), tumor burden (1.5 +/- 0.50), tumor volume (2.49 +/- 1.70) and delayed latency period of tumor formation was observed in group I (30 mg/kg) in comparison to carcinogen control. This study indicates that ACRH extract could be a promising skin tumor promotion suppressing agent at a lower dosage (30 mg/kg). Further studies are required to elucidate the underlying mechanism(s) leading to this effect. (+info)Alkylphenols from the roots of Ardisia brevicaulis induce G1 arrest and apoptosis through endoplasmic reticulum stress pathway in human non-small-cell lung cancer cells. (5/9)
From the roots of Ardisia brevicaulis DIELS, two new alkylphenol derivatives, named ardisiphenol E (2) and F (3), have been isolated together with a known alkylphenol, ardisiphenol D (1). The structures of 1-3 were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 exhibited strong cytotoxicities on two human non-small-cell lung cancer cell lines (H1299 and A549). We found that compounds 1 and 2 upregulated mRNA and protein expressions of endoplasmic reticulum (ER) stress markers including C/EBP homologous protein (CHOP), binding immunoglobulin protein (Bip) and inositol-requiring enzyme 1 (IRE1) indicating 1 and 2 are novel natural ER stress inducers. Treatments with 1 and 5 microM of 1 or 2 triggered G1 arrest in H1299 and A549 cells with concomitant downregulation of ubiquitin fusion degradation protein 1 (Ufd1) and S-phase kinase-associated protein 2 (Skp2) proteins and the accumulation of p27, the key axes of ER stress-mediated G1 arrest. Compounds 1 and 2 also induced apoptosis at high concentrations (10, 20 microM) which was shown to be coupled with the upregulation of CHOP and Bim, the activation of caspase-9, caspase-3 and poly(ADP-ribose) polymerase (PARP) cleavage. These results indicate that compounds 1 and 2 induce ER stress that subsequently causes G1 arrest and apoptosis in human non-small-cell lung cancer cells and they may have potential anticancer effects. (+info)Anti-tumor effect of Ardisia crispa hexane fraction on 7, 12-dimethylbenz[alpha]anthracene-induced mouse skin papillomagenesis. (6/9)
(+info)The hexane fraction of Ardisia crispa Thunb. A. DC. roots inhibits inflammation-induced angiogenesis. (7/9)
(+info)Complete plastid genome sequence of the basal asterid Ardisia polysticta Miq. and comparative analyses of asterid plastid genomes. (8/9)
(+info)Ardisia is a genus of evergreen trees and shrubs in the primrose family (Primulaceae) that are native to tropical and subtropical regions around the world. Some species of Ardisia have medicinal uses, but there is no single medical definition for 'Ardisia' as it is not a term used to describe a specific medical condition or treatment.
In traditional medicine, some Ardisia species have been used to treat various health issues such as digestive disorders, skin conditions, and respiratory infections. However, it is important to note that the use of Ardisia for medicinal purposes has not been extensively studied in clinical trials, and its safety and efficacy are not well-established. Therefore, it is recommended to consult with a healthcare provider before using any Ardisia species or products derived from them for medicinal purposes.
I apologize for any confusion, but "Myrsinaceae" is not a medical term. It is a taxonomic category in botany, specifically a family of flowering plants that includes shrubs and small trees. The plants in this family are primarily found in tropical and subtropical regions around the world.
If you have any questions related to medical terminology or health science, I would be happy to help.
Croton oil is a highly toxic, irritant, and vesicant liquid that is derived from the seeds of the croton tiglium plant. It is a type of unsaturated fatty acid known as an octadecatrienoic acid, and it contains a mixture of various chemical compounds including crotonic acid, diglycerides, and phorbol esters.
Croton oil is commonly used in laboratory research as a pharmacological tool to study the mechanisms of inflammation, pain, and skin irritation. It can also be used as a veterinary medicine to treat certain types of intestinal parasites in animals. However, due to its high toxicity and potential for causing severe burns and blisters on the skin, it is not used in human medicine.
It's important to note that croton oil should only be handled by trained professionals in a controlled laboratory setting, as improper use or exposure can result in serious injury or death.