A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species is ARTERITIS VIRUS, EQUINE.
Infections caused by viruses of the genus ARTERIVIRUS.
The type species of the genus ARTERIVIRUS and the etiologic agent of an important equine respiratory disease causing abortion, pneumonia, or other infections.
A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. Airborne transmission is common.
An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.
A family of viruses, of the order NIDOVIRALES, containing spherical virions. In contrast to CORONAVIRIDAE, no protruding spikes are obvious on the surface.
A species ARTERIVIRUS, occurring in a number of transplantable mouse tumors. Infected mice have permanently elevated serum levels of lactate dehydrogenase.
A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)
An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
Ribonucleic acid that makes up the genetic material of viruses.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The study of medicines derived from botanical sources.
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
Use of plants or herbs to treat diseases or to alleviate pain.
A genus of basiodiomycetous fungi in the family Coriolaceae. Members are known for infesting wood.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Communications networks connecting various hardware devices together within or between buildings by means of a continuous cable or voice data telephone system.

Genetic diversity of equine arteritis virus. (1/87)

Equine arteritis viruses (EAV) from Europe and America were compared by phylogenetic analysis of 43 isolates obtained over four decades. An additional 22 virus sequences were retrieved from GenBank. Fragments of the glycoprotein G(L) and the replicase genes were amplified by RT-PCR, prior to sequencing and construction of phylogenetic trees. The trees revealed many distinctive lineages, consistent with prolonged diversification within geographically separated host populations. Two large groups and five subgroups were distinguished. Group I consisted mainly of viruses from North America, whilst group II consisted mainly of European isolates. In most instances, where the geographic origin of the viruses appeared to be at variance with the phylogenetically predicted relationships, the horses from which the viruses were recovered had been transported between Europe and America or vice versa. Analysis of the replicase gene revealed similar phylogenetic relationships although not all of the groups were as clearly defined. Virus strains CH1 (Switzerland, 1964) and S1 (Sweden, 1989) represented separate 'outgroups' based on analysis of both genomic regions. The results of this study confirm the value of the G(L) gene of EAV for estimating virus genetic diversity and as a useful tool for tracing routes by which EAV is spread. In addition, computer-assisted predictions of antigenic sites on the G(L) protein revealed considerable variability among the isolates, especially with respect to regions associated with neutralization domains.  (+info)

Genetic divergence with emergence of novel phenotypic variants of equine arteritis virus during persistent infection of stallions. (2/87)

The persistently infected carrier stallion is the critical natural reservoir of equine arteritis virus (EAV), as venereal infection of mares frequently occurs after breeding to such stallions. Two Thoroughbred stallions that were infected during the 1984 outbreak of equine viral arteritis in central Kentucky subsequently became long-term EAV carriers. EAV genomes amplified from the semen of these two stallions were compared by sequence analysis of the six 3' open reading frames (ORFs 2 through 7), which encode the four known structural proteins and two uncharacterized glycoproteins. The major variants of the EAV population that sequentially arose within the reproductive tract of each carrier stallion varied by approximately 1% per year, and the heterogeneity of the viral quasispecies increased during the course of long-term persistent infection. The various ORFs of the dominant EAV variants evolved independently, and there was apparently strong selective pressure on the uncharacterized GP3 protein during persistent infection. Amino acid changes also occurred in the V1 variable region of the GL protein. This region has been previously identified as a crucial neutralization domain, and selective pressures exerted on the V1 region during persistent EAV infection led to the emergence of virus variants with distinct neutralization properties. Thus, evolution of the EAV quasispecies that occurs during persistent infection of the stallion clearly can influence viral phenotypic properties such as neutralization and perhaps virulence.  (+info)

Equine arteritis virus derived from an infectious cDNA clone is attenuated and genetically stable in infected stallions. (3/87)

Virus derived from an infectious cDNA clone of equine arteritis virus (EAV030H) was intranasally inoculated into two stallions, neither of which subsequently developed clinical manifestations of equine viral arteritis (EVA). Virus was isolated from nasal swabs and mononuclear cells collected from both stallions +info)

Genetic stability of equine arteritis virus during horizontal and vertical transmission in an outbreak of equine viral arteritis. (4/87)

An imported carrier stallion (A) from Europe was implicated in causing an extensive outbreak of equine viral arteritis (EVA) on a Warmblood breeding farm in Pennsylvania, USA. Strains of equine arteritis virus (EAV) present in the semen of two carrier stallions (A and G) on the farm were compared to those in tissues of foals born during the outbreak, as well as viruses present in the semen of two other stallions that became persistently infected carriers of EAV following infection during the outbreak. The 2822 bp segment encompassing ORFs 2-7 (nt 9807-12628; which encode the G(S), GP3, GP4, G(L), M and N proteins, respectively) was directly amplified by RT-PCR from semen samples and foal tissues. Nucleotide and phylogenetic analyses confirmed that virus present in the semen of stallion A initiated the outbreak. The genomes of viruses present in most foal tissues (10/11) and serum from an acutely infected mare collected during the outbreak were identical to that of virus present in the lung of the first foal that died of EVA. Virus in the placenta of one foal differed by one nucleotide (99.9% identity) from the predominant outbreak virus. The relative genetic stability of viruses that circulated during the outbreak contrasts markedly with the heterogeneous virus populations variously present in the semen of persistently infected stallions on the farm. These findings are consistent with the hypothesis that the carrier stallion can be a source of genetic diversity of EAV, and that outbreaks of EVA can be initiated by the horizontal aerosol transmission of specific viral variants that occur in the semen of particular carrier stallions.  (+info)

The open reading frame 3 of equine arteritis virus encodes an immunogenic glycosylated, integral membrane protein. (5/87)

Open reading frame 3 (ORF 3) of equine arteritis virus (EAV) is predicted to encode a glycosylated membrane protein (GP3) that is uncharacterized. ORF 3 of the American Type Culture Collection strain of EAV was in vitro transcribed and the encoded GP3 protein was in vitro translated with and without canine microsomal membranes. The GP3 protein was approximately 17 kDa after in vitro translation without canine microsomal membranes whereas the glycosylated form, after translation with microsomal membranes, was a diffuse band of 36-42 kDa, indicating that the GP3 protein is extensively glycosylated. Deglycosylation reduced the GP3 protein to approximately 17 kDa, the same size as that translated without microsomal membranes, indicating that the signal sequence was not cleaved. The EAV GP3 protein was membrane associated and not released as a soluble protein, in marked contrast to the ORF 3-encoded proteins of some other arteriviruses. The GP3 protein was protected from protease digestion in closed membrane vesicles, suggesting that the protein extends into the membrane vesicles and is anchored by the N-terminal signal sequence, a C-terminal hydrophobic domain, or both, but does not span the membrane three times. A GP3 protein lacking the C-terminal transmembrane domain remained membrane associated, indicating that this terminus is not a necessary membrane anchor. Sera from stallions persistently infected with EAV and horses immunized repeatedly with the modified live EAV vaccine contained antibodies specific for the GP3 protein. The data indicate that the GP3 protein is an extensively glycosylated membrane protein that is immunogenic during some EAV infections.  (+info)

Neuropathogenicity and sensitivity to antibody neutralization of lactate dehydrogenase-elevating virus are determined by polylactosaminoglycan chains on the primary envelope glycoprotein. (6/87)

Common strains of lactate dehydrogenase-elevating virus (LDV, an arterivirus), such as LDV-P and LDV-vx, are highly resistant to antibody neutralization and invariably establish a viremic, persistent, yet asymptomatic, infection in mice. Other LDV strains, LDV-C and LDV-v, have been identified that, in contrast, are highly susceptible to antibody neutralization and are incapable of a high viremic persistent infection, but at the same time have gained the ability to cause paralytic disease in immunosuppressed C58 and AKR mice. Our present results further indicate that these phenotypic differences represent linked properties that correlate with the number of N-glycosylation sites associated with the single neutralization epitope on the short ectodomain of the primary envelope glycoprotein, VP-3P. The VP-3P ectodomains of LDV-P/vx possess three N-glycosylation sites, whereas those of LDV-C/v lack the two N-terminal sites. We have now isolated four independent neutralization escape variants of neuropathogenic LDV-C and LDV-v on the basis of their ability to establish a high viremic persistent infection in mice. The VP-3P ectodomains of all four variants had specifically regained two N-glycosylation sites concomitant with decreased immunogenicity of the neutralization eptitope and decreased sensitivity to antibody neutralization as well as loss of neuropathogenicity.  (+info)

IFN-gamma-independent IgG2a production in mice infected with viruses and parasites. (7/87)

After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced against killed viruses were IgG1. This IgG1 antiviral response was suppressed when live virions were added to inactivated viral particles. These results indicate that the IgG2a preponderance is related to the infectious process itself rather than to the type of antigen involved. Since IFN-gamma is known to stimulate IgG2a production by activated B lymphocytes and to be secreted after infection, we examined the role of this cytokine in the antibody isotypic distribution caused by LDV. Most IgG2a responses were relatively unaffected in mice deficient for the IFN-gamma receptor or treated with anti-IFN-gamma antibody. A similar IFN-gamma-independent IgG2a secretion was observed after infection with the parasites Toxoplasma gondii and Trypanosoma cruzi. However, the IFN-gamma-independent IgG2a production triggered by infection still required the presence of functional T(h) lymphocytes. Therefore, signal(s) other than IFN-gamma secretion may explain the T(h)-dependent isotypic bias in antibody secretion triggered by viruses and parasites.  (+info)

Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses. (8/87)

The effects of three representative disinfectants, chlorine (sodium hypochlorite), iodine (potassium tetraglicine triiodide), and quaternary ammonium compound (didecyldimethylammonium chloride), on several exotic disease viruses were examined. The viruses used were four enveloped viruses (vesicular stomatitis virus, African swine fever virus, equine viral arteritis virus, and porcine reproductive and respiratory syndrome virus) and two non-enveloped viruses (swine vesicular disease virus (SVDV) and African horse sickness virus (AHSV)). Chlorine was effective against all viruses except SVDV at concentrations of 0.03% to 0.0075%, and a dose response was observed. Iodine was very effective against all viruses at concentrations of 0.015% to 0.0075%, but a dose response was not observed. Quaternary ammonium compound was very effective in low concentration of 0.003% against four enveloped viruses and AHSV, but it was only effective against SVDV with 0.05% NaOH. Electron microscopic observation revealed the probable mechanism of each disinfectant. Chlorine caused complete degeneration of the viral particles and also destroyed the nucleic acid of the viruses. Iodine destroyed mainly the inner components including nucleic acid of the viruses. Quaternary ammonium compound induced detachment of the envelope of the enveloped viruses and formation of micelle in non-enveloped viruses. According to these results, chlorine and iodine disinfectants were quite effective against most of the viruses used at adequately high concentration. The effective concentration of quaternary ammonium compound was the lowest among the disinfectants examined.  (+info)

Arterivirus is a type of enveloped, single-stranded, positive-sense RNA virus that belongs to the family Arteriviridae. These viruses are named after their initial discovery in arteries and have since been found to infect a wide range of mammals, including pigs, horses, cats, and primates.

Arteriviruses can cause various diseases, such as porcine reproductive and respiratory syndrome (PRRS) in pigs, equine arteritis virus (EAV) in horses, and simian hemorrhagic fever virus (SHFV) in non-human primates. In humans, Arterivirus infection is rare, but some cases of human infection with porcine reproductive and respiratory syndrome virus have been reported.

Arteriviruses are characterized by their unique viral structure, including a distinctive "coronavirus-like" appearance due to the presence of club-shaped projections on their surface called peplomers. However, they differ from coronaviruses in several ways, such as genome organization and replication strategy.

Overall, Arterivirus is an important group of viruses that can cause significant economic losses in the livestock industry and pose a potential threat to human health.

Arterivirus infections are viral diseases caused by members of the Arteriviridae family, which includes several species that can infect a variety of animals. The most well-known arterivirus is the equine arteritis virus (EAV), which causes equine arteritis in horses. Other examples include the porcine reproductive and respiratory syndrome virus (PRRSV) in pigs, and simian hemorrhagic fever virus (SHFV) in non-human primates.

Arterivirus infections typically cause respiratory or reproductive symptoms, depending on the specific virus and host species. For example, EAV can cause respiratory disease, abortion, and infertility in horses, while PRRSV primarily affects the reproductive system of pigs, causing abortions, stillbirths, and weak piglets.

Transmission of arteriviruses typically occurs through direct contact with infected animals or their bodily fluids, such as respiratory droplets or semen. Some arteriviruses can also be transmitted vertically, from mother to offspring, during pregnancy or birth.

There are currently no specific treatments for arterivirus infections, and prevention efforts focus on biosecurity measures, such as quarantine and vaccination of susceptible animals.

I'm sorry for any confusion, but there seems to be a mistake in your question. "Arteritis Virus, Equine" is not a recognized medical term or virus in humans or animals. There is a condition called "Equine Viral Arteritis (EVA)," which is a viral disease that affects horses and other equine species. However, it does not affect humans.

Equine Viral Arteritis (EVA) is caused by the Equine Arteritis Virus (EAV). This virus primarily affects the respiratory system and can cause symptoms such as fever, lethargy, loss of appetite, and a runny nose in infected horses. In some cases, it may also lead to inflammation of the lining of blood vessels (vasculitis), which can result in abortion in pregnant mares or infertility in stallions.

It's essential to maintain proper biosecurity measures when dealing with horses, especially those that have been exposed to EVA, to prevent its spread and protect the health of other equine populations.

Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) is an enveloped, positive-stranded RNA virus belonging to the Arteriviridae family. It is the causative agent of Porcine Respiratory and Reproductive Syndrome (PRRS), also known as "blue ear disease" or "porcine reproductive and respiratory syndrome."

The virus primarily affects pigs, causing a wide range of clinical signs including respiratory distress in young animals and reproductive failure in pregnant sows. The infection can lead to late-term abortions, stillbirths, premature deliveries, and weak or mummified fetuses. In growing pigs, PRRSV can cause pneumonia, which is often accompanied by secondary bacterial infections.

PRRSV has a tropism for cells of the monocyte-macrophage lineage, and it replicates within these cells, leading to the release of pro-inflammatory cytokines and the development of the clinical signs associated with the disease. The virus is highly infectious and can spread rapidly in susceptible pig populations, making it a significant concern for the swine industry worldwide.

It's important to note that PRRSV has two distinct genotypes: Type 1 (European) and Type 2 (North American). Both types have a high degree of genetic diversity, which can make controlling the virus challenging. Vaccination is available for PRRSV, but it may not provide complete protection against all strains of the virus, and it may not prevent infection or shedding. Therefore, biosecurity measures, such as strict sanitation and animal movement controls, are critical to preventing the spread of this virus in pig populations.

Nidovirales is an order of viruses that includes important pathogens such as coronaviruses and arteriviruses. These viruses are characterized by their large, complex genomes and the production of nested sets of subgenomic mRNAs during replication. They have a positive-sense, single-stranded RNA genome and are enveloped. The name "Nidovirales" is derived from the Latin word "nidus," meaning "nest," which refers to the nested set of subgenomic mRNAs produced during replication.

Coronaviruses, which include well-known human pathogens such as SARS-CoV, MERS-CoV and SARS-CoV-2 (which causes COVID-19), primarily infect the respiratory tract and can cause a range of symptoms from mild cold-like illness to severe pneumonia.

Arteriviruses, on the other hand, mainly infect animals and are associated with diseases such as porcine reproductive and respiratory syndrome (PRRS) in pigs and simian hemorrhagic fever in non-human primates.

It's important to note that Nidovirales have a high potential for cross-species transmission, which can lead to the emergence of new viruses with the ability to infect humans and cause disease.

Arteriviridae is a family of enveloped, positive-strand RNA viruses that infect a variety of animal hosts, including mammals and birds. The name "Arteriviridae" comes from the fact that some members of this family were initially identified as causes of diseases affecting arteries and the vascular system.

The genome of Arteriviridae viruses is around 12-16 kilobases in length and contains several open reading frames (ORFs) that encode various structural and non-structural proteins. The replication of these viruses occurs in the cytoplasm of infected cells, and they are known to have a complex transcription strategy involving discontinuous transcription and production of subgenomic mRNAs.

Arteriviridae includes several important veterinary pathogens, such as porcine reproductive and respiratory syndrome virus (PRRSV), equine arteritis virus (EAV), and lactate dehydrogenase-elevating virus (LDV) of mice. These viruses can cause a range of clinical symptoms in their respective hosts, including respiratory distress, reproductive failure, and immunosuppression.

Human pathogens belonging to Arteriviridae are not yet known, although some members of this family have been found to infect human cells in vitro. Further research is needed to determine the potential impact of Arteriviridae viruses on human health.

Lactate dehydrogenase-elevating virus (LDV) is an RNA virus that primarily infects mice. It is a member of the family Arteriviridae and is unique to murine species. LDV infection results in a persistent, chronic viremia without causing any overt signs of disease in the host. However, it is associated with a significant increase in serum lactate dehydrogenase (LDH) activity due to virus-induced damage to infected cells.

The virus infects various tissues and cell types, including macrophages and hepatocytes, and establishes a persistent infection by evading the host's immune response. LDV has been widely used as a model system for studying viral pathogenesis, persistence, and immunosuppression in mice.

It is important to note that Lactate dehydrogenase-elevating virus is not known to infect humans or other primates, and it is primarily studied in the context of basic research on viral infections and the immune response.

Porcine Reproductive and Respiratory Syndrome (PRRS) is a viral disease that affects pigs, causing reproductive failure in breeding herds and respiratory illness in young pigs. The disease is caused by the PRRS virus, which belongs to the family Arteriviridae.

In pregnant sows, PRRS can cause abortions, stillbirths, mummified fetuses, and weak or infertile offspring. In growing pigs, it can lead to pneumonia, reduced growth rates, and increased susceptibility to other infections. The virus is highly contagious and can spread rapidly within a herd through direct contact with infected pigs, aerosols, or contaminated fomites.

PRRS is a significant disease of global importance, causing substantial economic losses to the swine industry. Control measures include biosecurity practices, vaccination, and testing to detect and eliminate the virus from affected herds. However, there is no specific treatment for PRRS, and eradication of the virus from the pig population is unlikely due to its widespread distribution and ability to persist in infected animals and the environment.

RNA-dependent RNA polymerase, also known as RNA replicase, is an enzyme that catalyzes the production of RNA from an RNA template. It plays a crucial role in the replication of certain viruses, such as positive-strand RNA viruses and retroviruses, which use RNA as their genetic material. The enzyme uses the existing RNA strand as a template to create a new complementary RNA strand, effectively replicating the viral genome. This process is essential for the propagation of these viruses within host cells and is a target for antiviral therapies.

A viral RNA (ribonucleic acid) is the genetic material found in certain types of viruses, as opposed to viruses that contain DNA (deoxyribonucleic acid). These viruses are known as RNA viruses. The RNA can be single-stranded or double-stranded and can exist as several different forms, such as positive-sense, negative-sense, or ambisense RNA. Upon infecting a host cell, the viral RNA uses the host's cellular machinery to translate the genetic information into proteins, leading to the production of new virus particles and the continuation of the viral life cycle. Examples of human diseases caused by RNA viruses include influenza, COVID-19 (SARS-CoV-2), hepatitis C, and polio.

An open reading frame (ORF) is a continuous stretch of DNA or RNA sequence that has the potential to be translated into a protein. It begins with a start codon (usually "ATG" in DNA, which corresponds to "AUG" in RNA) and ends with a stop codon ("TAA", "TAG", or "TGA" in DNA; "UAA", "UAG", or "UGA" in RNA). The sequence between these two points is called a coding sequence (CDS), which, when transcribed into mRNA and translated into amino acids, forms a polypeptide chain.

In eukaryotic cells, ORFs can be located in either protein-coding genes or non-coding regions of the genome. In prokaryotic cells, multiple ORFs may be present on a single strand of DNA, often organized into operons that are transcribed together as a single mRNA molecule.

It's important to note that not all ORFs necessarily represent functional proteins; some may be pseudogenes or result from errors in genome annotation. Therefore, additional experimental evidence is typically required to confirm the expression and functionality of a given ORF.

Viral nonstructural proteins (NS) are viral proteins that are not part of the virion structure. They play various roles in the viral life cycle, such as replication of the viral genome, transcription, translation regulation, and modulation of the host cell environment to favor virus replication. These proteins are often produced in large quantities during infection and can manipulate or disrupt various cellular pathways to benefit the virus. They may also be involved in evasion of the host's immune response. The specific functions of viral nonstructural proteins vary depending on the type of virus.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

A viral genome is the genetic material (DNA or RNA) that is present in a virus. It contains all the genetic information that a virus needs to replicate itself and infect its host. The size and complexity of viral genomes can vary greatly, ranging from a few thousand bases to hundreds of thousands of bases. Some viruses have linear genomes, while others have circular genomes. The genome of a virus also contains the information necessary for the virus to hijack the host cell's machinery and use it to produce new copies of the virus. Understanding the genetic makeup of viruses is important for developing vaccines and antiviral treatments.

I'm sorry for any confusion, but "horses" is not a medical term. It is the common name given to the species *Equus ferus caballus*, which are large domesticated mammals used for transportation, work, and recreation. If you have any questions about horses or a related topic that you would like a medical perspective on, please let me know and I'd be happy to help!

Cricetinae is a subfamily of rodents that includes hamsters, gerbils, and relatives. These small mammals are characterized by having short limbs, compact bodies, and cheek pouches for storing food. They are native to various parts of the world, particularly in Europe, Asia, and Africa. Some species are popular pets due to their small size, easy care, and friendly nature. In a medical context, understanding the biology and behavior of Cricetinae species can be important for individuals who keep them as pets or for researchers studying their physiology.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.

Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.

It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.

Herbal medicine, also known as botanical medicine or phytomedicine, refers to the use of plants and plant extracts for therapeutic purposes. This traditional form of medicine has been practiced for thousands of years across various cultures worldwide. It involves the utilization of different parts of a plant, such as leaves, roots, seeds, flowers, and fruits, either in their whole form or as extracts, infusions, decoctions, tinctures, or essential oils.

Herbal medicines are believed to contain active compounds that can interact with the human body, influencing its physiological processes and helping to maintain or restore health. Some herbs have been found to possess pharmacological properties, making them valuable in treating various ailments, including digestive disorders, respiratory conditions, sleep disturbances, skin issues, and cardiovascular diseases.

However, it is essential to note that the regulation of herbal medicines varies significantly between countries, and their safety, efficacy, and quality may not always be guaranteed. Therefore, consulting a healthcare professional before starting any herbal medicine regimen is advisable to ensure proper usage, dosage, and potential interactions with other medications or health conditions.

Traditional Chinese Medicine (TCM) is a system of medicine that has been developed in China over thousands of years. It is based on the philosophy that the body's vital energy (Qi) circulates through a network of channels called meridians, and that disease results from an imbalance or blockage in this flow of Qi.

TCM uses a variety of treatments to restore balance and promote health, including acupuncture, herbal medicine, moxibustion (the burning of herbs near the skin), cupping, dietary therapy, and tuina (Chinese massage). The use of Chinese herbal medicines is a major component of TCM, with formulas often consisting of combinations of several different herbs tailored to the individual patient's needs.

In addition to these treatments, TCM practitioners may also use diagnostic techniques such as pulse diagnosis and tongue examination to assess a person's overall health and determine the underlying cause of their symptoms. The goal of TCM is not only to treat specific symptoms or diseases but to address the root causes of illness and promote overall wellness.

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

"Poria" is not a term commonly used in medical terminology. However, it might be a reference to "Poria cocos," a type of fungus that is sometimes used in traditional Chinese medicine. In this context, "Poria" is said to have anti-inflammatory, diuretic, and sedative properties, although its efficacy and safety are not well-studied or established by modern medical standards.

It's important to note that the use of traditional herbal remedies like "Poria cocos" can interact with other medications and have side effects, so it's crucial to consult with a healthcare provider before using them.

Medicinal plants are defined as those plants that contain naturally occurring chemical compounds which can be used for therapeutic purposes, either directly or indirectly. These plants have been used for centuries in various traditional systems of medicine, such as Ayurveda, Chinese medicine, and Native American medicine, to prevent or treat various health conditions.

Medicinal plants contain a wide variety of bioactive compounds, including alkaloids, flavonoids, tannins, terpenes, and saponins, among others. These compounds have been found to possess various pharmacological properties, such as anti-inflammatory, analgesic, antimicrobial, antioxidant, and anticancer activities.

Medicinal plants can be used in various forms, including whole plant material, extracts, essential oils, and isolated compounds. They can be administered through different routes, such as oral, topical, or respiratory, depending on the desired therapeutic effect.

It is important to note that while medicinal plants have been used safely and effectively for centuries, they should be used with caution and under the guidance of a healthcare professional. Some medicinal plants can interact with prescription medications or have adverse effects if used inappropriately.

I'm sorry for any confusion, but "Local Area Networks" (LANs) are not a medical term. They are a common term in the field of computer networking. Here is a general definition:

A Local Area Network (LAN) is a network that connects computers and other devices in a relatively small area, typically a single building or a group of buildings. Most LANs are used to share resources such as printers, games or applications. A LAN is usually owned, created, managed and supported by a single organization, such as a school, hospital, or business.

If you have any questions related to medical terminology, I would be happy to help!

Viral RNA load and histological changes in tissues following experimental infection with an arterivirus of possums (wobbly ... The task is to characterise and mitigate the effects of koi sleepy disease, a poxvirus infection of carp species which places ... The task is to characterise and mitigate the effects of koi sleepy disease, a poxvirus infection of carp species which places ... Bueno, R., Perrott, M., Dunowska, M., Brosnahan, C., & Johnston, C. (2012, May). Demonstration of OsHV-1 infection in New ...
However, arteriviruses are known to cause persistent/asymptomatic infections (e.g., equine arteritis virus, simian hemorrhagic ... Vanmechelen B, Vergote V, Laenen L, Koundouno FR, Bore JA, Wada J, et al. Expanding the arterivirus host spectrum: Oliviers ... Arterivirus molecular biology and pathogenesis. J Gen Virol. 2013;94:2141-63. DOIPubMedGoogle Scholar ... Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019 On This Page ...
"Just because we havent diagnosed a human arterivirus infection yet doesnt mean that no human has been exposed. We havent ... September 25, 2023 , Global Prevalence of Asymptomatic Norovirus Infection in Outbreaks * September 25, 2023 , Mpox Infection ... Building bridges between infection prevention/epidemiology, scientific R&D, manufacturing and regulatory/compliance. ... While such arteriviruses are already considered a critical threat to macaque monkeys, no human infections have been reported to ...
We hypothesize that a deficiency of it may be relevant to the development of a severe infection. We also hypothesize that a ... We suggest that zinc supplementation may enhance the action of antimalarials to treat this infection.Zinc is the second most ... This manuscript summarizes the main mechanisms that link it to COVID-19 infection. ... IL-6 plays an important role on lung severe injury from COVID-19 infection.• Zinc inhibits SARS-COV RNA polymerase, inhibiting ...
te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ and van Hemert MJ: Zn(2+) inhibits coronavirus and arterivirus ... and severe pneumococcal infection in mice (133) resulting in shorter survival time after infection (134). Correspondingly, ... Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J and Pyrc K: Infection with human ... In turn, coronavirus infection was shown to impair mucociliary clearance (50) predisposing the lung for further viral and ...
... arterivirus infections MeSH C02.782.600.100.700 - porcine reproductive and respiratory syndrome MeSH C02.782.600.550 - ... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ...
These findings advance LDV as a model of arterivirus infection and viral persistence while adding to a growing body of ... Arterivirus/genética , Arterivirus/crescimento & desenvolvimento , Arterivirus/metabolismo , Carpas , Linhagem Celular , ... Mitochondria were protected from Ars-induced damage by WNV infection until late times in the infection cycle. The results ... suggesting SARS-CoV-2 entry into the brain by this route after intranasal infection. Our data indicate that direct infection of ...
PCV2 infection reduced PRRSV infection and PRRSV-associated CPE in PCV2/PRRSV AMs; the reduction of PRRSV infection in AMs was ... mediated by IFN-α generated by PCV2 infection. The reduced PRRSV-associated CPE in AMs and increased pro-inflammatory cytokine ... Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Authors: ... The results suggest that swine AMs were an important reservoir of PCV2; PCV2 infection reduced PRRSV infection and PRRSV- ...
keywords = "coronavirus, arterivirus, mesonivirus, ronivirus, autophagosome, autophagic flux, infection, replication, egression ...
Velthuis, Van Den Worm, Sims, Baric, Snijder et al., Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in ... Gammoh, Rink, Zinc in Infection and Inflammation, Nutrients. Gao, Li, Jiang, Impact of statins on ALI/ARDS: A meta-analysis, ... Wan, Sun, Kan, Guan, Zhang, Effect of statin therapy on mortality from infection and sepsis: a meta-analysis of randomized and ... Li, Ching, Hipple, Lopez, Sahibzada et al., Use of intravenous vitamin C in critically ill patients with COVID-19 infection, J ...
The arterivirus lactate dehydrogenase-elevating virus (LDV) causes life-long viremia in mice. Although LDV infection generally ... N2 - The arterivirus lactate dehydrogenase-elevating virus (LDV) causes life-long viremia in mice. Although LDV infection ... AB - The arterivirus lactate dehydrogenase-elevating virus (LDV) causes life-long viremia in mice. Although LDV infection ... Although LDV infection generally does not cause disease, infected mice that are homozygous for the Fv1 n allele are prone to ...
Infection route Direct contact (droplet infection) from infected pigs; indirectly via stable dust, equipment, hands, clothes ... PRRSV is an enveloped single-stranded RNA virus of the genus Arterivirus. It is divided into the two species PRRSV 1 (formerly ... Longer-standing infections can be detected by PCR from tonsillar scrapings, as the virus can be detected in the tonsils for the ... Within hours of infection, the virus is detectable in its target cells, the alveolar macrophages. In addition to colonising ...
Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol. ( ... Ultrastructural characterization of arterivirus replication structures: reshaping the endoplasmic reticulum to accommodate ... 7) Lukacs, N. (1994) Detection of virus infection in plants and differentiation between coexisting viruses by monoclonal ... fixed at 7 hours post-infection. J2 was detected using immunogold conjugated to protein A. G: Golgi complex, M: mitochondria, N ...
Arterivirus Infections [C01.925.782.600.100] Arterivirus Infections * Coronaviridae Infections [C01.925.782.600.550] ... caused by members of the Coronaviridae family: do not confuse with CORONAVIRUS INFECTIONS caused by members of the Coronavirus ... Infections à Coronaviridae Entry term(s):. Coronaviridae Infection. Infection, Coronaviridae. Infections, Coronaviridae. ...
MERS-CoV infection did not prevent the IFN-induced nuclear translocation of phosphorylated STAT1, in contrast to infection with ... Following infection, we observed rapidly increasing viral RNA synthesis and release of high titres of infectious progeny, ... infections are commonly associated with respiratory and enteric disease in humans and animals. The 2003 outbreak of severe ... Zhong Y., Tan Y. W., Liu D. X. 2012; Recent progress in studies of arterivirus- and coronavirus-host interactions. Viruses 4: ...
Tumor Virus Infections. Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but ... A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. The European strain is called Lelystad virus. ... Burkitt LymphomaHerpesviridae InfectionsVirus DiseasesTumor Virus InfectionsOrthomyxoviridae InfectionsEpstein-Barr Virus ... InfectionsRespiratory Syncytial Virus InfectionsInfluenza, HumanHIV InfectionsDNA Virus InfectionsCell Transformation, ViralRNA ...
Novel arterivirus discovered in Amazonian rodents unveiling a potential viral spillover threat Discovery of a novel arterivirus ... Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research suggests. ...
PRRS infection is widespread in US herds so care must be taken to both confirm an active infection and to rule out other ... The PRRS virus is an enveloped RNA virus in the genus Arterivirus, classified in the virus family, Arteriviridae. There is ... Boars are known to shed PRRS virus in semen for up to 92 days post-infection and can infect dams during breeding. Infection of ... Other infections are common in pigs with PRRS. Differential diagnosis for respiratory disease includes lesions or co-infections ...
Laaksi, Vitamin D and respiratory infection in adults, Proc Nutr Soc. Lee, Hecke, Roberts, Vitamin D: A rapid review of the ... Velthuis, Van Den Worm, She, Sims, Baric et al., Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and ... Gombart, Pierre, Maggini, A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, ... Bergman, Lindh, Björkhem-Bergman, Lindh, Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of ...
Gammoh NZ, Rink L. Zinc in infection and inflammation. Nutrients. 2017;9(6):E624. doi:10.3390/nu9060624PubMedGoogle Scholar ... Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these ... Hemilä H. Vitamin C, respiratory infections and the immune system. Trends Immunol. 2003;24(11):579-580. doi:10.1016/j.it. ... Davelaar FG, Bos J. Ascorbic acid and infectious bronchitis infections in broilers. Avian Pathol. 1992;21(4):581-589. doi: ...
Effect of oral gavage treatment with ZnAL42 and other metallo-ion formulations on influenza A H5N1 and H1N1 virus infections in ... Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these ...
Infection o Coinfection: infection with HBV and HDV at the same time ▪ Greater likelihood of a more severe acute infection ... Arterivirus o No human cases SUPPLEMENTAL NOTES ARENAVIRIDAE • Old World o Lymphocytic choriomeningitis (LCM) virus o Lassa ... Neonatal infection • Vaccine is available • Serologic Markers for the Diagnosis of HBV Infection o HBsAg - hepatitis B surface ... CORONAVIRIDAE • Cause 15% of coldlike infections in adults • Higher in children o Some pediatric diarrhea o Targets the GI ...
Probiotic to cure deadly C-defile infection. Olive oil in the ear to cure a life-threatening infection.. Mullein tea to cure ... 2. Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity I n V i t r o and Zinc Ionophores Block the Replication of ... 3. Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin. ... If I do later, I have some ideas in mind which I think might work only if used soon after the infection. The experiences I ...
Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes (Lond). 2013;37(3):333-40. [PMID:22546772] ... Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these ... Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999;3(9):756-61. [PMID:10488881] ... They are also at risk for immune deficiencies and for respiratory infections.[61] However, there is mixed evidence about the ...
A) Structure of SARS-CoV-2. (B) Mechanism of SARS-CoV-2 infection.. 2. Key targets and their roles in SARS-CoV-2 infection ... Te V.A., van den Worm S.H., Sims A.C., Baric R.S., Snijder E.J., van Hemert M.J. Zn(2+) inhibits coronavirus and arterivirus ... Lin S.C., Ho C.T., Chuo W.H., Li S., Wang T.T., Lin C.C. Effective inhibition of MERS-CoV infection by resveratrol. BMC Infect ... Virus infection is initiated by the interaction between S protein and host cell surface receptors. The S protein would be ...
Tian D, Wei Z, Zevenhoven-Dobbe JC, Liu R, Tong G, Snijder EJ, Yuan S. Arterivirus minor envelope proteins are a major ... Immunomodulation and quasispecies evolution have been speculated to play a crucial role in PRRS virus infection and its chronic ... Immune selection. During an infection, predominant variants would be those that possess advantageous changes in their genome ... Heterodimerization of the two major proteins is essential for arterivirus infectivity. J Virol. 2003, 77:97-104. Snijder EJ, ...
Wong, He, Siragam, Bi, Mbikay et al., Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection, Virol. ... Velthuis, Van Den Worm, Sims, Baric, Snijder et al., Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In ... Qiu, Kroeker, He, Kozak, Audet et al., Prophylactic Efficacy of Quercetin 3-β-O -d-Glucoside against Ebola Virus Infection, ... Li, Zhu, Ji, Quanquin, Deng et al., Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated ...
About 30% of people tested after recovering from novel coronavirus infection, do not have significant antibody levels to ... Article Zn Inhibits Coronavirus and Arterivirus RNA Polymerase Activ…]. However, being a ++ ion, extracellular zinc requires ... respiratory syncytial virus infections, and pneumonia. Results of a community field trial reported herein indicated that 25(OH) ... chronic respiratory tract infections (RTIs), diabetes mellitus, and hypertension. Patients with chronic diseases have ...
With COVID-19 infections, glucose 6-phosphate dehydrogenase (G6PD) deficiency facilitates human coronavirus infection due to ... al., Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of ... But diet plays a critical role in fortifying the immune system and in helping the body fight off and overcome infections such ... In a severe COVID-19 infection, it has been shown to induce a therapeutic blockade of inflammation. NAC is a potent redox- ...
Impact of equine herpesvirus type 1 (EHV-1) infection on the migration of monocytic cells through equine nasal mucosa. Comp ... Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology. ... in charge of antigen uptake through receptor-mediated endocytosis and function in the transport from sites of infection to ...

No FAQ available that match "arterivirus infections"

No images available that match "arterivirus infections"