Pain in the joint.
Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.
A species of ALPHAVIRUS causing an acute dengue-like fever.
One of the Indian Ocean Islands, east of Madagascar. Its capital is Saint-Denis. It was discovered in 1507 by the Portuguese and claimed by France in 1638. It was first colonized in 1662 as Isle de Bourbon but renamed Reunion in 1793. In 1946 it was made an overseas department of France. The name commemorates the reunion of the revolutionaries from Marseilles with the National Guard in Paris in 1792. (From Webster's New Geographical Dictionary, 1988, p1011; Room, Brewer's Dictionary of Names, 1992, p454; French Embassy)
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.
A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, VIRGINIAMYCIN FACTOR M1 and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
Arthritis is a general term used to describe inflammation in the joints, often resulting in pain, stiffness, and reduced mobility, which can be caused by various conditions such as osteoarthritis, rheumatoid arthritis, gout, or lupus.
Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.
Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.
'Joint diseases' is a broad term that refers to medical conditions causing inflammation, degeneration, or functional impairment in any part of a joint, including the cartilage, bone, ligament, tendon, or bursa, thereby affecting movement and potentially causing pain, stiffness, deformity, or reduced range of motion.
Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
A broad category of sleep disorders characterized by either hypersomnolence or insomnia. The three major subcategories include intrinsic (i.e., arising from within the body) (SLEEP DISORDERS, INTRINSIC), extrinsic (secondary to environmental conditions or various pathologic conditions), and disturbances of circadian rhythm. (From Thorpy, Sleep Disorders Medicine, 1994, p187)
A genus of TOGAVIRIDAE, also known as Group A arboviruses, serologically related to each other but not to other Togaviridae. The viruses are transmitted by mosquitoes. The type species is the SINDBIS VIRUS.
Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Clinical or physiological indicators that precede the onset of disease.
Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
A genus of gram-positive bacteria in the family Cellulomonadaceae.
A symptom complex consisting of pain, muscle tenderness, clicking in the joint, and limitation or alteration of mandibular movement. The symptoms are subjective and manifested primarily in the masticatory muscles rather than the temporomandibular joint itself. Etiologic factors are uncertain but include occlusal dysharmony and psychophysiologic factors.
A group of rare autosomal dominant diseases, commonly characterized by atypical URTICARIA (hives) with systemic symptoms that develop into end-organ damage. The atypical hives do not involve T-cell or autoantibody. Cryopyrin-associated periodic syndrome includes three previously distinct disorders: Familial cold autoinflammatory syndrome; Muckle-Wells Syndrome; and CINCA Syndrome, that are now considered to represent a disease continuum, all caused by NLRP3 protein mutations.
Contagious infection with human B19 Parvovirus most commonly seen in school age children and characterized by fever, headache, and rashes of the face, trunk, and extremities. It is often confused with rubella.
Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.
Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.
A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease.
An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.
The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)
Inflammation of a muscle or muscle tissue.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Aspects of health and disease related to travel.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
A characteristic symptom complex.
Tumors or cancer of the human BREAST.
Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.
The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Therapy with two or more separate preparations given for a combined effect.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Adrenal cortex hormones are steroid hormones produced by the outer portion of the adrenal gland, consisting of glucocorticoids, mineralocorticoids, and androgens, which play crucial roles in various physiological processes such as metabolism regulation, stress response, electrolyte balance, and sexual development and function.
Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
An organoplatinum compound that possesses antineoplastic activity.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Disease having a short and relatively severe course.
Substances that reduce or suppress INFLAMMATION.
Substances that reduce the growth or reproduction of BACTERIA.

Filtration leukocytapheresis therapy in rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. (1/722)

OBJECTIVE: To determine the efficacy and safety of filtration leukocytapheresis (LCP) for the treatment of rheumatoid arthritis (RA). METHODS: Twenty-five patients with drug-resistant RA were randomly assigned to undergo filtration LCP and 7 to undergo sham apheresis (control group) in a randomized, double-blind, placebo-controlled study. Three apheresis procedures were performed, with 1-week intervals between procedures. The efficacy of filtration LCP was evaluated according to the American College of Rheumatology definition of improvement in RA. Medications for each patient were unchanged for at least 6 months prior to enrollment and throughout the study. RESULTS: Tender joint counts, swollen joint counts, patient assessment of pain and global severity, physician assessment of global severity, and Health Assessment Questionnaire Disability Index were significantly improved in the LCP group compared with the control group (P < 0.05 for patient assessment of pain; P < 0.01 for all others). Seventy-nine percent of the patients in the LCP group exhibited significant overall improvement, while none of the patients in the control group were improved (P < 0.001). CONCLUSION: The results indicate that filtration LCP is an effective and well-tolerated treatment for patients with drug-resistant RA.  (+info)

An acutely painful elbow as a first presentation of von Willebrand's disease. (2/722)

A 26 year old woman presented to the accident and emergency department with a painful right elbow. There had been no history of trauma. Clinical examination suggested an effusion, which was confirmed on radiological examination. Her elbow was aspirated and revealed a haemarthrosis. Subsequent investigations revealed a diagnosis of von Willebrand's disease (vWD). A spontaneously occurring effusion of the elbow may be due to a haemarthrosis. Aspiration of blood in the absence of trauma may lead to a diagnosis of an occult coagulopathy in addition to relieving pain. The diagnosis and treatment of vWD is discussed.  (+info)

Prevalence of joint pain is higher among women in rural Japan than urban Japanese-American women in Hawaii. (3/722)

OBJECTIVE: Environmental factors such as farming contribute to the frequency of joint symptoms. The purpose of this study is to explore the possible role of environment (lifestyle), by comparing the prevalence of joint pain between Japanese in a rural farming district in Japan and in urban Hawaii. SUBJECTS AND METHODS: Current or previous pain at specific joints was surveyed among 222 women in rural Japan and 638 Japanese women in urban Hawaii aged 60-79. The age adjusted prevalence was compared using logistic regression. RESULTS: The prevalence of pain at one or more joints was approximately 70% in Japan and 50% in Hawaii. The prevalence of knee pain in Japan ranged from 36% at ages 60-69 years to 53% at 70-79 years (mean 41%), whereas knee pain affected only 20% of women in Hawaii in both age groups. The odds ratio (and 95% CI) was 3.2 (2.1, 4.8) for knee pain, and 4.0 (2.2, 7.4) for mid-back pain in Japan, compared with Hawaii. Pain was also significantly more common in Japan at the shoulder, elbow, and ankle, but not at other joints. Women in Japan were shorter and weighed less than in Hawaii. Adjustment for body mass index increased the odds ratios to 4.4 (2.9, 6.8) for knee, and 4.5 (2.4, 8.5) for mid-back pain. CONCLUSION: Although the potential influence of cultural factors or other sources of bias cannot be ruled out, the large differences in the prevalence of pain at specific joints suggest that environmental factors are probably responsible, because both populations are of similar genetic stock.  (+info)

Health benefits of joint replacement surgery for patients with osteoarthritis: prospective evaluation using independent assessments in Scotland. (4/722)

STUDY OBJECTIVES: To determine extent of change in psychological, functional, and social health after knee and hip joint replacement surgery using independent assessments. DESIGN: Patients were recruited before surgery and interviewed preoperatively, three months after surgery, and nine months after surgery. Interviews were conducted in the patients' own homes. SETTING: Two orthopaedic surgery units in Scotland. PARTICIPANTS: A consecutive sample of 107 patients with osteoarthritis having primary replacement of the knee or hip. MAIN OUTCOME MEASURES: Assessments of depression, anxiety, pain, functional activity, informal care, and formal service utilisation were made at three time points. MAIN RESULTS: Anxiety and pain were significantly reduced and functional activity levels significantly increased after surgery. While gains in anxiety and pain reduction occurred between the preoperative and three month assessments, gains in activity were made between the three month and nine month assessments. Although pain was reduced and activity increased, levels of depression were unchanged after surgery. Patients reported need for assistance with fewer activities after surgery, but increases in the use of formal services and increases in the number of hours per week of informal support received were observed at both three month and nine month follow up. CONCLUSIONS: The main benefit of joint replacement surgery is pain relief. Gains in functional activity, particularly mobility and leisure activities are made by many patients. Paradoxically, surgery for osteoarthritis seems to act as a "gateway" to increases in formal and informal community support, which are maintained into the longer term.  (+info)

Knee pain and the infrapatellar branch of the saphenous nerve. (5/722)

Pain over the front of the knee is common after surgery or trauma but often a definite diagnosis is difficult to make. Over the past year we have seen five cases in which the pain could be ascribed to damage to a branch of the infrapatellar branch of the saphenous nerve. Two were subsequent to trauma and three to surgical procedures. In all five cases surgical exploration gave symptomatic relief. Eight cadaveric knees were prosected to explore further the anatomy of this nerve in relation to the injuries. Injury to one of these branches should be considered in cases of persistent anterior, anteromedial or anterolateral knee pain or neurological symptoms following surgery or trauma.  (+info)

The wrist of the formula 1 driver. (6/722)

OBJECTIVES: During formula 1 driving, repetitive cumulative trauma may provoke nerve disorders such as nerve compression syndrome as well as osteoligament injuries. A study based on interrogatory and clinical examination of 22 drivers was carried out during the 1998 formula 1 World Championship in order to better define the type and frequency of these lesions. METHODS: The questions investigated nervous symptoms, such as paraesthesia and diminishment of sensitivity, and osteoligamentous symptoms, such as pain, specifying the localisation (ulnar side, dorsal aspect of the wrist, snuff box) and the effect of the wrist position on the intensity of the pain. Clinical examination was carried out bilaterally and symmetrically. RESULTS: Fourteen of the 22 drivers reported symptoms. One suffered cramp in his hands at the end of each race and one described a typical forearm effort compartment syndrome. Six drivers had effort "osteoligamentous" symptoms: three scapholunate pain; one medial hypercompression of the wrist; two sequellae of a distal radius fracture. Seven reported nerve disorders: two effort carpal tunnel syndromes; one typical carpal tunnel syndrome; one effort cubital tunnel syndrome; three paraesthesia in all fingers at the end of a race, without any objective signs. CONCLUSIONS: This appears to be the first report of upper extremity disorders in competition drivers. The use of a wrist pad to reduce the effects of vibration may help to prevent trauma to the wrist in formula 1 drivers.  (+info)

Is diagnostic arthroscopy of the hip worthwhile? A prospective review of 328 adults investigated for hip pain. (7/722)

We describe a prospective study of 328 patients undergoing arthroscopy of the hip. Arthrography, CT or MRI was performed when clinically indicated. A preoperative diagnosis was reached in 174 patients (53%), while the remaining 154 were diagnosed as having 'idiopathic hip pain'. In seven patients, access to the hip was inadequate. Arthroscopy altered the diagnosis in 176 hips (53%). The new primary diagnoses were osteoarthritis (75 patients), osteochondral defects (34), torn labra (23), synovitis (11) and loose bodies (9). In 172 hips (52%) an operative procedure was undertaken. In the remaining 84 patients (26%), arthroscopy neither changed the diagnosis nor provided surgical treatment. Arthroscopy of the hip is considered to be of value in assessing and treating the adult patient with pain in the hip of uncertain cause.  (+info)

O'nyong-nyong fever in south-central Uganda, 1996-1997: clinical features and validation of a clinical case definition for surveillance purposes. (8/722)

O'nyong-nyong (ONN) fever, caused by infection with a mosquito-borne central African alphavirus, is an acute, nonfatal illness characterized by polyarthralgia. During 1996-1997, south-central Uganda experienced the second ONN fever epidemic ever recognized. Among 391 persons interviewed and sampled, 40 cases of confirmed and 21 of presumptive, well-characterized acute, recent, or previous ONN fever were identified through active case-finding efforts or during a household serosurvey and by the application of clinical and laboratory criteria. Among confirmed cases, the knees and ankles were the joints most commonly affected. The median duration of arthralgia was 6 days (range, 2-21 days) and of immobilization was 4 days (range, 1-14 days). In the majority, generalized skin rash was reported, and nearly half had lymphadenopathy, mainly of the cervical region. Viremia was documented in 16 cases, primarily during the first 3 days of illness, and in some of these, body temperature was normal. During this epidemic, the combination of fever, arthralgia, and lymphadenopathy had a specificity of 83% and a sensitivity of 61% in the identification of cases of ONN fever and thus could be useful for surveillance purposes.  (+info)

Arthralgia is a medical term that refers to pain in the joints. It does not involve inflammation, which would be referred to as arthritis. The pain can range from mild to severe and may occur in one or multiple joints. Arthralgia can have various causes, including injuries, infections, degenerative conditions, or systemic diseases. In some cases, the underlying cause of arthralgia remains unknown. Treatment typically focuses on managing the pain and addressing the underlying condition if it can be identified.

Alphavirus infections refer to a group of diseases caused by viruses belonging to the Alphavirus genus of the Togaviridae family. These viruses are transmitted to humans through the bite of infected mosquitoes, and can cause a range of symptoms depending on the specific virus and the individual's immune response.

Some of the more common alphaviruses that cause human disease include:

* Chikungunya virus (CHIKV): This virus is transmitted by Aedes mosquitoes and can cause a fever, rash, and severe joint pain. While most people recover from CHIKV infection within a few weeks, some may experience long-term joint pain and inflammation.
* Eastern equine encephalitis virus (EEEV): This virus is transmitted by mosquitoes that feed on both birds and mammals, including humans. EEEV can cause severe neurological symptoms such as fever, headache, seizures, and coma. It has a high mortality rate of up to 30-50% in infected individuals.
* Western equine encephalitis virus (WEEV): This virus is also transmitted by mosquitoes that feed on both birds and mammals. WEEV can cause mild flu-like symptoms or more severe neurological symptoms such as fever, headache, and seizures. It has a lower mortality rate than EEEV but can still cause significant illness.
* Venezuelan equine encephalitis virus (VEEV): This virus is transmitted by mosquitoes that feed on horses and other mammals, including humans. VEEV can cause mild flu-like symptoms or more severe neurological symptoms such as fever, headache, and seizures. It is considered a potential bioterrorism agent due to its ability to cause severe illness and death in large populations.

There are no specific treatments for alphavirus infections other than supportive care to manage symptoms. Prevention measures include avoiding mosquito bites through the use of insect repellent, wearing long sleeves and pants, and staying indoors during peak mosquito hours. Public health efforts also focus on reducing mosquito populations through environmental controls such as eliminating standing water and using insecticides.

Chikungunya virus (CHIKV) is an alphavirus from the Togaviridae family that is transmitted to humans through the bite of infected mosquitoes, primarily Aedes aegypti and Aedes albopictus. The name "Chikungunya" is derived from a Makonde word meaning "to become contorted," which describes the stooped posture developed as a result of severe arthralgia (joint pain) that is a primary symptom of infection with this virus.

CHIKV infection typically causes a febrile illness, characterized by an abrupt onset of high fever, severe joint pain, muscle pain, headache, nausea, fatigue, and rash. While the symptoms are usually self-limiting and resolve within 10 days, some individuals may experience persistent or recurring joint pain for several months or even years after the initial infection.

There is no specific antiviral treatment available for Chikungunya virus infection, and management primarily focuses on relieving symptoms with rest, fluids, and over-the-counter pain relievers such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs). Prevention measures include avoiding mosquito bites through the use of insect repellent, wearing long sleeves and pants, staying in air-conditioned or screened rooms, and eliminating standing water where mosquitoes breed.

Chikungunya virus is found primarily in Africa, Asia, and the Indian subcontinent, but it has also caused outbreaks in Europe and the Americas due to the spread of its vectors, Aedes aegypti and Aedes albopictus. The virus can cause large-scale epidemics, with millions of cases reported during outbreaks. There is currently no approved vaccine for Chikungunya virus infection.

In the context of medicine, particularly in relation to surgery, "reunion" refers to the process or state of separate parts coming back together or healing into a solid mass. This term is often used in the context of wound healing, where it describes the closure and joining of the edges of a wound. It can also be used in orthopedic surgery to describe the reattachment or fusion of broken bones after a fracture. However, it's not a common medical term and might not be found in general medical dictionaries or resources.

Tenosynovitis is a medical condition characterized by inflammation of the lining (synovium) surrounding a tendon, which is a cord-like structure that attaches muscle to bone. This inflammation can cause pain, swelling, and difficulty moving the affected joint. Tenosynovitis often affects the hands, wrists, feet, and ankles, and it can result from various causes, including infection, injury, overuse, or autoimmune disorders like rheumatoid arthritis. Prompt diagnosis and treatment of tenosynovitis are essential to prevent complications such as tendon rupture or chronic pain.

Aromatase inhibitors (AIs) are a class of drugs that are primarily used in the treatment of hormone-sensitive breast cancer in postmenopausal women. They work by inhibiting the enzyme aromatase, which is responsible for converting androgens into estrogens. By blocking this conversion, AIs decrease the amount of estrogen in the body, thereby depriving hormone-sensitive breast cancer cells of the estrogen they need to grow and multiply.

There are three main types of aromatase inhibitors:

1. Letrozole (Femara) - a non-steroidal AI that is taken orally once a day.
2. Anastrozole (Arimidex) - another non-steroidal AI that is also taken orally once a day.
3. Exemestane (Aromasin) - a steroidal AI that is taken orally once a day.

In addition to their use in breast cancer treatment, AIs are also sometimes used off-label for the treatment of estrogen-dependent conditions such as endometriosis and uterine fibroids. However, it's important to note that the use of aromatase inhibitors can have significant side effects, including hot flashes, joint pain, and bone loss, so they should only be used under the close supervision of a healthcare provider.

Cryoglobulinemia is a medical condition characterized by the presence of abnormal proteins called cryoglobulins in the blood. These proteins become insoluble at lower temperatures and can form immune complexes that can cause inflammation and damage to small blood vessels when they precipitate in cooler parts of the body.

Cryoglobulinemia is often associated with underlying conditions such as autoimmune diseases (such as rheumatoid arthritis or lupus), chronic infections (such as hepatitis C), and certain types of cancer (such as lymphoma). Symptoms can vary widely, but may include purpura (purple spots on the skin), joint pain, peripheral neuropathy (nerve damage causing numbness or weakness), fatigue, and kidney problems.

The diagnosis of cryoglobulinemia is typically made by detecting cryoglobulins in the blood through a special test that requires the blood sample to be kept at cold temperatures. Treatment for cryoglobulinemia depends on the underlying cause, but may include medications such as corticosteroids, immunosuppressants, or chemotherapy drugs.

Virginiamycin is not a medical condition or disease, but rather an antibiotic used in veterinary medicine to promote growth and prevent or treat certain bacterial infections in animals, particularly in livestock such as cattle, swine, and poultry. It is a mixture of two components, virginiamycin M1 and virginiamycin S1, which have antibacterial properties against gram-positive bacteria.

Virginiamycin belongs to the streptogramin class of antibiotics and works by binding to the bacterial ribosome, inhibiting protein synthesis and ultimately killing the bacteria. It is not approved for use in humans, except under certain circumstances as part of an investigational new drug (IND) protocol or in specific medical devices.

It's important to note that the use of antibiotics in livestock can contribute to the development of antibiotic-resistant bacteria, which can have negative impacts on human health. Therefore, responsible and judicious use of antibiotics is essential to minimize this risk.

Whipple disease is a rare, systemic disorder caused by the bacterium Tropheryma whipplei. The condition primarily affects the gastrointestinal (GI) tract, leading to malabsorption and various digestive symptoms. The bacteria are ingested and then invade the small intestine's lining, where they disrupt nutrient absorption and cause widespread inflammation.

The classic symptoms of Whipple disease include diarrhea, weight loss, abdominal pain, and arthralgia or joint pain. Other possible manifestations may involve the cardiovascular system, central nervous system (CNS), lungs, kidneys, eyes, skin, and endocrine system.

The diagnosis of Whipple disease typically involves a combination of clinical symptoms, radiologic findings, and laboratory tests. The gold standard for diagnosing Whipple disease is the detection of Tropheryma whipplei in biopsy samples taken from the small intestine. This can be done through various methods such as polymerase chain reaction (PCR), immunohistochemistry, or electron microscopy.

Untreated Whipple disease can lead to severe complications and even be fatal. However, with appropriate antibiotic therapy, the prognosis is generally good. Long-term antibiotic treatment is typically required to ensure complete eradication of the bacteria and prevent relapses.

Arthritis is a medical condition characterized by inflammation in one or more joints, leading to symptoms such as pain, stiffness, swelling, and reduced range of motion. There are many different types of arthritis, including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, and lupus, among others.

Osteoarthritis is the most common form of arthritis and is caused by wear and tear on the joints over time. Rheumatoid arthritis, on the other hand, is an autoimmune disorder in which the body's immune system mistakenly attacks the joint lining, causing inflammation and damage.

Arthritis can affect people of all ages, including children, although it is more common in older adults. Treatment for arthritis may include medications to manage pain and reduce inflammation, physical therapy, exercise, and in some cases, surgery.

Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the triad of fever, evanescent rash, and arthralgia or arthritis. It is a type of Still's disease that occurs in adults, typically between the ages of 16 and 35, but it can occur at any age.

The exact cause of AOSD is not known, but it is thought to be an autoimmune disorder, in which the body's immune system mistakenly attacks healthy tissue. The symptoms of AOSD can vary from person to person, but they often include:

* High spiking fever (often 102°F or higher) that may come and go for several weeks or months
* Salmon-pink, non-itchy rash that typically appears on the trunk and extremities and fades after a day or two
* Joint pain and swelling that can affect any joint, but is often worse in the morning and improves with activity
* Sore throat and other respiratory symptoms
* Fatigue and muscle weakness
* Swollen lymph nodes
* Liver enlargement and abnormal liver function tests
* Abnormal white blood cell count

The diagnosis of AOSD is based on a combination of clinical, laboratory and imaging findings. There are no specific diagnostic tests for AOSD, so the diagnosis is often one of exclusion, meaning that other possible causes of the symptoms must be ruled out before a diagnosis of AOSD can be made.

Treatment of AOSD typically involves the use of medications to reduce inflammation and suppress the immune system. These may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying antirheumatic drugs (DMARDs) such as methotrexate or biologics like TNF inhibitors.

It is important to note that AOSD is a rare condition and its symptoms can vary from person to person, so it's essential to consult with a healthcare professional for an accurate diagnosis and treatment plan.

Vascular skin diseases are a group of medical conditions that affect the blood vessels in the skin. These disorders can be caused by problems with the structure or function of the blood vessels, which can lead to various symptoms such as redness, discoloration, pain, itching, and ulcerations. Some examples of vascular skin diseases include:

1. Rosacea: a chronic skin condition that causes redness, flushing, and visible blood vessels in the face.
2. Eczema: a group of inflammatory skin conditions that can cause redness, itching, and dryness. Some types of eczema, such as varicose eczema, are associated with problems with the veins.
3. Psoriasis: an autoimmune condition that causes red, scaly patches on the skin. Some people with psoriasis may also develop psoriatic arthritis, which can affect the blood vessels in the skin and joints.
4. Vasculitis: a group of conditions that cause inflammation of the blood vessels. This can lead to symptoms such as redness, pain, and ulcerations.
5. Livedo reticularis: a condition that causes a net-like pattern of discoloration on the skin, usually on the legs. It is caused by abnormalities in the small blood vessels.
6. Henoch-Schönlein purpura: a rare condition that causes inflammation of the small blood vessels, leading to purple spots on the skin and joint pain.
7. Raynaud's phenomenon: a condition that affects the blood vessels in the fingers and toes, causing them to become narrow and restrict blood flow in response to cold temperatures or stress.

Treatment for vascular skin diseases depends on the specific condition and its severity. It may include medications, lifestyle changes, and in some cases, surgery.

Joint diseases is a broad term that refers to various conditions affecting the joints, including but not limited to:

1. Osteoarthritis (OA): A degenerative joint disease characterized by the breakdown of cartilage and underlying bone, leading to pain, stiffness, and potential loss of function.
2. Rheumatoid Arthritis (RA): An autoimmune disorder causing inflammation in the synovial membrane lining the joints, resulting in swelling, pain, and joint damage if left untreated.
3. Infectious Arthritis: Joint inflammation caused by bacterial, viral, or fungal infections that spread through the bloodstream or directly enter the joint space.
4. Gout: A type of arthritis resulting from the buildup of uric acid crystals in the joints, typically affecting the big toe and characterized by sudden attacks of severe pain, redness, and swelling.
5. Psoriatic Arthritis (PsA): An inflammatory joint disease associated with psoriasis, causing symptoms such as pain, stiffness, and swelling in the joints and surrounding tissues.
6. Juvenile Idiopathic Arthritis (JIA): A group of chronic arthritis conditions affecting children, characterized by joint inflammation, pain, and stiffness.
7. Ankylosing Spondylitis: A form of arthritis primarily affecting the spine, causing inflammation, pain, and potential fusion of spinal vertebrae.
8. Bursitis: Inflammation of the fluid-filled sacs (bursae) that cushion joints, leading to pain and swelling.
9. Tendinitis: Inflammation or degeneration of tendons, which connect muscles to bones, often resulting in pain and stiffness near joints.

These conditions can impact the function and mobility of affected joints, causing discomfort and limiting daily activities. Proper diagnosis and treatment are essential for managing joint diseases and preserving joint health.

Muscular diseases, also known as myopathies, refer to a group of conditions that affect the functionality and health of muscle tissue. These diseases can be inherited or acquired and may result from inflammation, infection, injury, or degenerative processes. They can cause symptoms such as weakness, stiffness, cramping, spasms, wasting, and loss of muscle function.

Examples of muscular diseases include:

1. Duchenne Muscular Dystrophy (DMD): A genetic disorder that results in progressive muscle weakness and degeneration due to a lack of dystrophin protein.
2. Myasthenia Gravis: An autoimmune disease that causes muscle weakness and fatigue, typically affecting the eyes and face, throat, and limbs.
3. Inclusion Body Myositis (IBM): A progressive muscle disorder characterized by muscle inflammation and wasting, typically affecting older adults.
4. Polymyositis: An inflammatory myopathy that causes muscle weakness and inflammation throughout the body.
5. Metabolic Myopathies: A group of inherited disorders that affect muscle metabolism, leading to exercise intolerance, muscle weakness, and other symptoms.
6. Muscular Dystonias: Involuntary muscle contractions and spasms that can cause abnormal postures or movements.

It is important to note that muscular diseases can have a significant impact on an individual's quality of life, mobility, and overall health. Proper diagnosis and treatment are crucial for managing symptoms and improving outcomes.

Dyssomnias are a category of sleep disorders that involve problems with the amount, quality, or timing of sleep. They can be broken down into several subcategories, including:

1. Insomnia: This is characterized by difficulty falling asleep or staying asleep, despite adequate opportunity and circumstances to do so. It can result in distress, impairment in social, occupational, or other areas of functioning, and/or feelings of dissatisfaction with sleep.
2. Hypersomnias: These are disorders that involve excessive sleepiness during the day, even after having adequate opportunity for sleep. Narcolepsy is an example of a hypersomnia.
3. Sleep-related breathing disorders: These include conditions such as obstructive sleep apnea, in which breathing is repeatedly interrupted during sleep, leading to poor sleep quality and excessive daytime sleepiness.
4. Circadian rhythm sleep-wake disorders: These involve disruptions to the body's internal clock, which can result in difficulty falling asleep or staying asleep at desired times. Jet lag and shift work disorder are examples of circadian rhythm sleep-wake disorders.
5. Parasomnias: These are disruptive sleep-related events that occur during various stages of sleep, such as sleepwalking, night terrors, and REM sleep behavior disorder.

Dyssomnias can have significant impacts on a person's quality of life, and it is important to seek medical evaluation if you are experiencing symptoms. Treatment may involve lifestyle changes, medication, or other interventions depending on the specific type of dyssomnia.

Alphaviruses are a genus of single-stranded, positive-sense RNA viruses that belong to the family Togaviridae. They are enveloped viruses and have a icosahedral symmetry with a diameter of approximately 70 nanometers. Alphaviruses are transmitted to vertebrates by mosquitoes and other arthropods, and can cause a range of diseases in humans and animals, including arthritis, encephalitis, and rash.

Some examples of alphaviruses that can infect humans include Chikungunya virus, Eastern equine encephalitis virus, Western equine encephalitis virus, Sindbis virus, and Venezuelan equine encephalitis virus. These viruses are usually found in tropical and subtropical regions around the world, and can cause outbreaks of disease in humans and animals.

Alphaviruses have a wide host range, including mammals, birds, reptiles, and insects. They replicate in the cytoplasm of infected cells and have a genome that encodes four non-structural proteins (nsP1 to nsP4) involved in viral replication, and five structural proteins (C, E3, E2, 6K, and E1) that form the virion.

Prevention and control of alphavirus infections rely on avoiding mosquito bites, using insect repellents, wearing protective clothing, and reducing mosquito breeding sites. There are no specific antiviral treatments available for alphavirus infections, but supportive care can help manage symptoms. Vaccines are available for some alphaviruses, such as Eastern equine encephalitis virus and Western equine encephalitis virus, but not for others, such as Chikungunya virus.

Leukocytoclastic vasculitis, cutaneous is a type of vasculitis that is limited to the skin. Vasculitis refers to inflammation of the blood vessels, which can cause damage to the vessel walls and impair blood flow to various tissues in the body. In leukocytoclastic vasculitis, the small blood vessels (capillaries and venules) in the skin become inflamed, leading to damage and destruction of the vessel walls.

The term "leukocytoclastic" refers to the presence of nuclear debris from white blood cells (leukocytes) that have been destroyed within the affected blood vessels. This type of vasculitis is often associated with the deposition of immune complexes (formed by the interaction between antibodies and antigens) in the walls of the blood vessels, which triggers an inflammatory response.

Cutaneous leukocytoclastic vasculitis typically presents as palpable purpura (small to large, raised, purple or red spots on the skin), usually located on the lower extremities, but can also affect other areas of the body. Other symptoms may include burning or itching sensations in the affected area, and in some cases, ulcers or necrosis (tissue death) may occur.

The diagnosis of cutaneous leukocytoclastic vasculitis is typically made based on clinical presentation, laboratory tests, and histopathological examination of a skin biopsy specimen. Treatment usually involves addressing any underlying causes or triggers, as well as managing symptoms with medications such as corticosteroids or immunosuppressive agents.

Prodromal symptoms refer to the early, often nonspecific signs or symptoms that appear before the onset of a particular disease or condition. These symptoms can vary widely depending on the specific illness, and they may include things like fatigue, headache, muscle aches, or changes in appetite or sleep patterns.

In some cases, prodromal symptoms may be mild and easily dismissed as simply feeling "under the weather." However, they can also serve as important warning signs that a more serious condition is on the horizon. For example, prodromal symptoms of a migraine headache might include mood changes, food cravings, or neck stiffness in the days leading up to the actual headache.

It's worth noting that not everyone who experiences prodromal symptoms will go on to develop the full-blown illness. However, if you notice any unusual or persistent symptoms that concern you, it's always a good idea to speak with your healthcare provider for further evaluation and guidance.

Infectious arthritis, also known as septic arthritis, is a type of joint inflammation that is caused by a bacterial or fungal infection. The infection can enter the joint through the bloodstream or directly into the synovial fluid of the joint, often as a result of a traumatic injury, surgery, or an underlying condition such as diabetes or a weakened immune system.

The most common symptoms of infectious arthritis include sudden onset of severe pain and swelling in the affected joint, fever, chills, and difficulty moving the joint. If left untreated, infectious arthritis can lead to serious complications such as joint damage or destruction, sepsis, and even death. Treatment typically involves antibiotics or antifungal medications to eliminate the infection, along with rest, immobilization, and sometimes surgery to drain the infected synovial fluid.

It is important to seek medical attention promptly if you experience symptoms of infectious arthritis, as early diagnosis and treatment can help prevent long-term complications and improve outcomes.

Henoch-Schönlein purpura (HSP) is a type of small vessel vasculitis, which is a condition characterized by inflammation of the blood vessels. HSP primarily affects children, but it can occur in adults as well. It is named after two German physicians, Eduard Heinrich Henoch and Johann Schönlein, who first described the condition in the mid-19th century.

The main feature of HSP is a purpuric rash, which is a type of rash that appears as small, red or purple spots on the skin. The rash is caused by leakage of blood from the small blood vessels (capillaries) beneath the skin. In HSP, this rash typically occurs on the legs and buttocks, but it can also affect other parts of the body, such as the arms, face, and trunk.

In addition to the purpuric rash, HSP is often accompanied by other symptoms, such as joint pain and swelling, abdominal pain, nausea, vomiting, and diarrhea. In severe cases, it can also affect the kidneys, leading to hematuria (blood in the urine) and proteinuria (protein in the urine).

The exact cause of HSP is not known, but it is thought to be related to an abnormal immune response to certain triggers, such as infections or medications. Treatment typically involves supportive care, such as pain relief and fluid replacement, as well as medications to reduce inflammation and suppress the immune system. In most cases, HSP resolves on its own within a few weeks or months, but it can lead to serious complications in some individuals.

"Tropheryma" is a genus of bacteria that includes the species "Tropheryma whipplei," which is the causative agent of Whipple's disease, a rare systemic infection that primarily affects the small intestine. The bacteria are gram-positive, rod-shaped, and have a unique ability to survive and replicate within human host cells, contributing to their pathogenicity. Infection typically occurs through the ingestion of contaminated food or water, and symptoms can include diarrhea, abdominal pain, weight loss, and various other systemic manifestations.

Temporomandibular Joint Dysfunction Syndrome, often abbreviated as TMJD or TMD, is a group of conditions that cause pain and dysfunction in the temporomandibular joint (TMJ) - the joint that connects the jawbone to the skull. Here's a more detailed medical definition:

Temporomandibular Joint Dysfunction Syndrome is a complex disorder characterized by pain, clicking, popping, or grating sounds in the TMJ; limited movement or locking of the jaw; and/or painful chewing movements. The condition may be caused by a variety of factors, including muscle tension, joint inflammation, structural problems with the joint itself, or injury to the head, neck, or jaw.

Symptoms of TMJD can include:
- Pain or tenderness in the face, jaw joint area, neck, and/or shoulders
- Limited ability to open the mouth wide
- Jaw locking, making it difficult to close or open the mouth
- Clicking, popping, or grating sounds in the TMJ when opening or closing the mouth
- A significant change in the way the upper and lower teeth fit together
- Headaches, earaches, dizziness, and hearing problems

Treatment for TMJD can vary depending on the severity of the condition and its underlying cause. It may include self-care practices such as eating soft foods, avoiding extreme jaw movements, and practicing relaxation techniques; physical therapy; medication to reduce pain and inflammation; dental treatments such as mouthguards or bite adjustments; and, in rare cases, surgery.

Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare, hereditary autoinflammatory disorders caused by mutations in the NLRP3 gene, which encodes the cryopyrin protein. The mutation leads to overactivation of the inflammasome, an intracellular complex that regulates the activation of inflammatory cytokines, resulting in uncontrolled inflammation.

CAPS include three clinical subtypes:

1. Familial Cold Autoinflammatory Syndrome (FCAS): This is the mildest form of CAPS and typically presents in infancy or early childhood with recurrent episodes of fever, urticaria-like rash, and joint pain triggered by cold exposure.
2. Muckle-Wells Syndrome (MWS): This subtype is characterized by more severe symptoms than FCAS, including recurrent fever, urticaria-like rash, joint pain, and progressive hearing loss. Patients with MWS are also at risk for developing amyloidosis, a serious complication that can lead to kidney failure.
3. Neonatal-Onset Multisystem Inflammatory Disease (NOMID): Also known as chronic infantile neurological cutaneous and articular syndrome (CINCA), this is the most severe form of CAPS. It presents at birth or in early infancy with fever, urticaria-like rash, joint inflammation, and central nervous system involvement, including chronic meningitis, developmental delay, and hearing loss.

Treatment for CAPS typically involves targeted therapies that block the overactive inflammasome, such as IL-1 inhibitors. Early diagnosis and treatment can help prevent long-term complications and improve quality of life for patients with these disorders.

Erythema infectiosum is a viral infection commonly known as "fifth disease." It is caused by the human parvovirus B19 and primarily affects children. The characteristic symptom of erythema infectiosum is a distinctive red rash on the cheeks, which gives the appearance of having been slapped, hence one of its other names, "slapped cheek syndrome." After a few days, the rash may spread to the arms, legs, and trunk, often in a lacy or net-like pattern. The rash is usually not itchy or painful.

In addition to the rash, people with erythema infectiosum may experience mild flu-like symptoms such as fever, headache, and fatigue. Some individuals may also develop joint pain and swelling, particularly adolescents and adults. In most cases, erythema infectiosum is a self-limiting illness that resolves within one to three weeks without specific treatment. However, the rash may come and go for several weeks, especially when exposed to sunlight, heat, or emotional stress.

Erythema infectiosum is usually spread through respiratory droplets when an infected person coughs or sneezes. It can also be transmitted through blood transfusions and from mother to fetus during pregnancy. While most cases of erythema infectiosum are mild, the infection can cause more severe complications in people with weakened immune systems, sickle cell disease, or chronic hemolytic anemia. Pregnant women who contract erythema infectiosum may have a higher risk of miscarriage, stillbirth, or premature delivery, especially during the first half of pregnancy.

Brucellosis is a bacterial infection caused by the Brucella species, which are gram-negative coccobacilli. It is a zoonotic disease, meaning it can be transmitted from animals to humans. The most common way for humans to contract brucellosis is through consumption of contaminated animal products, such as unpasteurized milk or undercooked meat, from infected animals like goats, sheep, and cattle.

Humans can also acquire the infection through direct contact with infected animals, their tissues, or bodily fluids, especially in occupational settings like farming, veterinary medicine, or slaughterhouses. In rare cases, inhalation of contaminated aerosols or laboratory exposure can lead to brucellosis.

The onset of symptoms is usually insidious and may include fever, chills, night sweats, headache, muscle and joint pain, fatigue, and loss of appetite. The infection can disseminate to various organs, causing complications such as endocarditis, hepatomegaly, splenomegaly, orchitis, and epididymoorchitis.

Diagnosis is confirmed through blood cultures, serological tests, or molecular methods like PCR. Treatment typically involves a long course of antibiotics, such as doxycycline combined with rifampin or streptomycin. Prevention measures include pasteurization of dairy products and cooking meat thoroughly before consumption. Vaccination is available for high-risk populations but not for general use due to the risk of adverse reactions and potential interference with serodiagnosis.

Fever, also known as pyrexia or febrile response, is a common medical sign characterized by an elevation in core body temperature above the normal range of 36.5-37.5°C (97.7-99.5°F) due to a dysregulation of the body's thermoregulatory system. It is often a response to an infection, inflammation, or other underlying medical conditions, and it serves as a part of the immune system's effort to combat the invading pathogens or to repair damaged tissues.

Fevers can be classified based on their magnitude:

* Low-grade fever: 37.5-38°C (99.5-100.4°F)
* Moderate fever: 38-39°C (100.4-102.2°F)
* High-grade or severe fever: above 39°C (102.2°F)

It is important to note that a single elevated temperature reading does not necessarily indicate the presence of a fever, as body temperature can fluctuate throughout the day and can be influenced by various factors such as physical activity, environmental conditions, and the menstrual cycle in females. The diagnosis of fever typically requires the confirmation of an elevated core body temperature on at least two occasions or a consistently high temperature over a period of time.

While fevers are generally considered beneficial in fighting off infections and promoting recovery, extremely high temperatures or prolonged febrile states may necessitate medical intervention to prevent potential complications such as dehydration, seizures, or damage to vital organs.

Rheumatoid factor (RF) is an autoantibody, specifically an immunoglobulin M (IgM) antibody, that can be detected in the blood serum of some people with rheumatoid arthritis (RA), other inflammatory conditions, and infectious diseases. RF targets the Fc portion of IgG, leading to immune complex formation and subsequent inflammation, which contributes to the pathogenesis of RA. However, not all patients with RA test positive for RF, and its presence does not necessarily confirm a diagnosis of RA. Other conditions can also lead to elevated RF levels, such as infections, liver diseases, and certain malignancies. Therefore, the interpretation of RF results should be considered alongside other clinical, laboratory, and imaging findings for an accurate diagnosis and appropriate management.

Facial pain is a condition characterized by discomfort or pain felt in any part of the face. It can result from various causes, including nerve damage or irritation, injuries, infections, dental problems, migraines, or sinus congestion. The pain can range from mild to severe and may be sharp, dull, constant, or intermittent. In some cases, facial pain can also be associated with other symptoms such as headaches, redness, swelling, or changes in sensation. Accurate diagnosis and treatment of the underlying cause are essential for effective management of facial pain.

An exanthem is a skin eruption or rash that often occurs as a symptom of various diseases, such as infectious illnesses. It can appear in different forms, including maculopapular (consisting of both macules and papules), vesicular (small fluid-filled blisters), petechial (small purple or red spots caused by bleeding under the skin), or erythematous (reddened). The rash can be localized to certain areas of the body or generalized, covering large parts or the entire body. Exanthems are usually accompanied by other symptoms related to the underlying disease, such as fever, cough, or muscle aches.

Familial Mediterranean Fever (FMF) is a hereditary inflammatory disorder that primarily affects people of Mediterranean ancestry, including populations from Turkey, Armenia, Arab countries, and Jewish communities from the Middle East. It is caused by mutations in the MEFV gene, which provides instructions for making a protein called pyrin or marenostrin.

The main features of FMF include recurrent episodes of fever, serositis (inflammation of the membranes lining the abdominal cavity, chest cavity, or heart), and polyserositis (inflammation affecting multiple serous membranes simultaneously). The attacks usually last between 12 and 72 hours and can be associated with severe abdominal pain, joint pain, and skin rashes.

The diagnosis of FMF is based on clinical criteria, family history, and genetic testing. Treatment typically involves the use of colchicine, an anti-inflammatory medication that helps prevent attacks and reduces the risk of long-term complications such as amyloidosis, a condition characterized by the buildup of abnormal protein deposits in various organs.

Early diagnosis and treatment of FMF are essential to prevent complications and improve quality of life for affected individuals.

Reactive arthritis is a form of inflammatory arthritis that occurs in response to an infection in another part of the body, such as the genitals, urinary tract, or gastrointestinal tract. It is also known as Reiter's syndrome. The symptoms of reactive arthritis include joint pain and swelling, typically affecting the knees, ankles, and feet; inflammation of the eyes, skin, and mucous membranes; and urethritis or cervicitis. It is more common in men than women and usually develops within 1-4 weeks after a bacterial infection. The diagnosis is made based on the symptoms, medical history, physical examination, and laboratory tests. Treatment typically includes antibiotics to eliminate the underlying infection and medications to manage the symptoms of arthritis.

Parvovirus B19, Human is a single-stranded DNA virus that primarily infects humans. It belongs to the Parvoviridae family and Erbovirus genus. This virus is the causative agent of erythema infectiosum, also known as fifth disease, a mild, self-limiting illness characterized by a facial rash and occasionally joint pain or inflammation.

Parvovirus B19 has a strong tropism for erythroid progenitor cells in the bone marrow, where it replicates and causes temporary suppression of red blood cell production (aplastic crisis) in individuals with underlying hemolytic disorders such as sickle cell disease or spherocytosis.

Additionally, Parvovirus B19 can cause more severe complications in immunocompromised individuals, pregnant women, and fetuses. Infection during pregnancy may lead to hydrops fetalis, anemia, or even fetal death, particularly in the first and second trimesters. Transmission of the virus occurs primarily through respiratory droplets and occasionally via blood transfusions or vertical transmission from mother to fetus.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Paclitaxel is a chemotherapeutic agent derived from the bark of the Pacific yew tree (Taxus brevifolia). It is an antimicrotubule agent that promotes the assembly and stabilization of microtubules, thereby interfering with the normal dynamic reorganization of the microtubule network that is essential for cell division.

Paclitaxel is used in the treatment of various types of cancer including ovarian, breast, lung, and pancreatic cancers. It works by inhibiting the disassembly of microtubules, which prevents the separation of chromosomes during mitosis, leading to cell cycle arrest and apoptosis (programmed cell death).

Common side effects of paclitaxel include neutropenia (low white blood cell count), anemia (low red blood cell count), alopecia (hair loss), peripheral neuropathy (nerve damage causing numbness or tingling in the hands and feet), myalgias (muscle pain), arthralgias (joint pain), and hypersensitivity reactions.

Temporomandibular Joint Disorders (TMD) refer to a group of conditions that cause pain and dysfunction in the temporomandibular joint (TMJ) and the muscles that control jaw movement. The TMJ is the hinge joint that connects the lower jaw (mandible) to the skull (temporal bone) in front of the ear. It allows for movements required for activities such as eating, speaking, and yawning.

TMD can result from various causes, including:

1. Muscle tension or spasm due to clenching or grinding teeth (bruxism), stress, or jaw misalignment
2. Dislocation or injury of the TMJ disc, which is a small piece of cartilage that acts as a cushion between the bones in the joint
3. Arthritis or other degenerative conditions affecting the TMJ
4. Bite problems (malocclusion) leading to abnormal stress on the TMJ and its surrounding muscles
5. Stress, which can exacerbate existing TMD symptoms by causing muscle tension

Symptoms of Temporomandibular Joint Disorders may include:
- Pain or tenderness in the jaw, face, neck, or shoulders
- Limited jaw movement or locking of the jaw
- Clicking, popping, or grating sounds when moving the jaw
- Headaches, earaches, or dizziness
- Difficulty chewing or biting
- Swelling on the side of the face

Treatment for TMD varies depending on the severity and cause of the condition. It may include self-care measures (like eating soft foods, avoiding extreme jaw movements, and applying heat or cold packs), physical therapy, medications (such as muscle relaxants, pain relievers, or anti-inflammatory drugs), dental work (including bite adjustments or orthodontic treatment), or even surgery in severe cases.

Myositis is a medical term that refers to inflammation of the muscle tissue. This condition can cause various symptoms, including muscle weakness, pain, swelling, and stiffness. There are several types of myositis, such as polymyositis, dermatomyositis, and inclusion body myositis, which have different causes and characteristics.

Polymyositis is a type of myositis that affects multiple muscle groups, particularly those close to the trunk of the body. Dermatomyositis is characterized by muscle inflammation as well as a skin rash. Inclusion body myositis is a less common form of myositis that typically affects older adults and can cause both muscle weakness and wasting.

The causes of myositis vary depending on the type, but they can include autoimmune disorders, infections, medications, and other medical conditions. Treatment for myositis may involve medication to reduce inflammation, physical therapy to maintain muscle strength and flexibility, and lifestyle changes to manage symptoms and prevent complications.

Immunoglobulin M (IgM) is a type of antibody that is primarily found in the blood and lymph fluid. It is the first antibody to be produced in response to an initial exposure to an antigen, making it an important part of the body's primary immune response. IgM antibodies are large molecules that are composed of five basic units, giving them a pentameric structure. They are primarily found on the surface of B cells as membrane-bound immunoglobulins (mlgM), where they function as receptors for antigens. Once an mlgM receptor binds to an antigen, it triggers the activation and differentiation of the B cell into a plasma cell that produces and secretes large amounts of soluble IgM antibodies.

IgM antibodies are particularly effective at agglutination (clumping) and complement activation, which makes them important in the early stages of an immune response to help clear pathogens from the bloodstream. However, they are not as stable or long-lived as other types of antibodies, such as IgG, and their levels tend to decline after the initial immune response has occurred.

In summary, Immunoglobulin M (IgM) is a type of antibody that plays a crucial role in the primary immune response to antigens by agglutination and complement activation. It is primarily found in the blood and lymph fluid, and it is produced by B cells after they are activated by an antigen.

I'm sorry for any confusion, but "travel" is not a term that has a specific medical definition. In general, travel refers to the act of moving or journeying from one place to another, often over long distances. However, in a medical context, it might refer to the recommendation that individuals with certain medical conditions or those who are immunocompromised avoid traveling to areas where they may be at increased risk of exposure to infectious diseases. It's always best to check with a healthcare professional for advice related to specific medical situations and travel.

A disease outbreak is defined as the occurrence of cases of a disease in excess of what would normally be expected in a given time and place. It may affect a small and localized group or a large number of people spread over a wide area, even internationally. An outbreak may be caused by a new agent, a change in the agent's virulence or host susceptibility, or an increase in the size or density of the host population.

Outbreaks can have significant public health and economic impacts, and require prompt investigation and control measures to prevent further spread of the disease. The investigation typically involves identifying the source of the outbreak, determining the mode of transmission, and implementing measures to interrupt the chain of infection. This may include vaccination, isolation or quarantine, and education of the public about the risks and prevention strategies.

Examples of disease outbreaks include foodborne illnesses linked to contaminated food or water, respiratory infections spread through coughing and sneezing, and mosquito-borne diseases such as Zika virus and West Nile virus. Outbreaks can also occur in healthcare settings, such as hospitals and nursing homes, where vulnerable populations may be at increased risk of infection.

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.

Chondrocalcinosis is a medical condition characterized by the deposition of calcium pyrophosphate dihydrate crystals in the fibrous cartilage (also known as chondral or articular cartilage) and/or the joint cavity (synovial fluid). This cartilage is present in various parts of the body, including the ears, nose, respiratory tract, and connective tissues such as those found in joints.

Calcium pyrophosphate dihydrate crystals are normally present in small amounts within the body; however, an overabundance of these crystals can lead to chondrocalcinosis. The condition is often associated with osteoarthritis and can affect people of all ages but is more common in older adults.

Chondrocalcinosis may not always cause symptoms, but when it does, they can include joint pain, stiffness, swelling, and warmth. These symptoms are similar to those seen in other forms of arthritis, making chondrocalcinosis difficult to diagnose based on symptoms alone. Diagnosis typically involves imaging techniques such as X-rays or ultrasounds, as well as joint fluid analysis to identify the presence of calcium pyrophosphate dihydrate crystals.

Treatment for chondrocalcinosis is generally focused on managing symptoms and addressing any underlying conditions that may contribute to the development or progression of the disease. This can include medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation, joint aspiration to remove excess fluid and crystals from the affected area, and physical therapy to maintain joint mobility and strength. In some cases, surgery may be necessary to repair or replace damaged joints.

Urticaria, also known as hives, is an allergic reaction that appears on the skin. It is characterized by the rapid appearance of swollen, pale red bumps or plaques (wheals) on the skin, which are often accompanied by itching, stinging, or burning sensations. These wheals can vary in size and shape, and they may change location and appear in different places over a period of hours or days. Urticaria is usually caused by an allergic reaction to food, medication, or other substances, but it can also be triggered by physical factors such as heat, cold, pressure, or exercise. The condition is generally harmless, but severe cases of urticaria may indicate a more serious underlying medical issue and should be evaluated by a healthcare professional.

Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.

Synovitis is a medical condition characterized by inflammation of the synovial membrane, which is the soft tissue that lines the inner surface of joint capsules and tendon sheaths. The synovial membrane produces synovial fluid, which lubricates the joint and allows for smooth movement.

Inflammation of the synovial membrane can cause it to thicken, redden, and become painful and swollen. This can lead to stiffness, limited mobility, and discomfort in the affected joint or tendon sheath. Synovitis may occur as a result of injury, overuse, infection, or autoimmune diseases such as rheumatoid arthritis.

If left untreated, synovitis can cause irreversible damage to the joint and surrounding tissues, including cartilage loss and bone erosion. Treatment typically involves a combination of medications, physical therapy, and lifestyle modifications to reduce inflammation and manage pain.

Musculoskeletal diseases are a group of medical conditions that affect the bones, joints, muscles, tendons, ligaments, and nerves. These diseases can cause pain, stiffness, limited mobility, and decreased function in the affected areas of the body. They include a wide range of conditions such as:

1. Osteoarthritis: A degenerative joint disease characterized by the breakdown of cartilage in joints, leading to pain, stiffness, and loss of mobility.
2. Rheumatoid arthritis: An autoimmune disorder that causes inflammation in the lining of the joints, resulting in swelling, pain, and bone erosion.
3. Gout: A form of arthritis caused by the buildup of uric acid crystals in the joints, leading to severe pain, redness, and swelling.
4. Osteoporosis: A condition characterized by weakened bones that are more susceptible to fractures due to decreased bone density.
5. Fibromyalgia: A disorder that causes widespread muscle pain, fatigue, and tenderness in specific areas of the body.
6. Spinal disorders: Conditions affecting the spine, such as herniated discs, spinal stenosis, or degenerative disc disease, which can cause back pain, numbness, tingling, or weakness.
7. Soft tissue injuries: Damage to muscles, tendons, and ligaments, often caused by overuse, strain, or trauma.
8. Infections: Bone and joint infections (septic arthritis or osteomyelitis) can cause pain, swelling, and fever.
9. Tumors: Benign or malignant growths in bones, muscles, or soft tissues can lead to pain, swelling, and limited mobility.
10. Genetic disorders: Certain genetic conditions, such as Marfan syndrome or Ehlers-Danlos syndrome, can affect the musculoskeletal system and cause various symptoms.

Treatment for musculoskeletal diseases varies depending on the specific condition but may include medications, physical therapy, exercise, surgery, or a combination of these approaches.

Rheumatic diseases are a group of disorders that cause pain, stiffness, and swelling in the joints, muscles, tendons, ligaments, or bones. They include conditions such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus (SLE), gout, ankylosing spondylitis, psoriatic arthritis, and many others. These diseases can also affect other body systems including the skin, eyes, lungs, heart, kidneys, and nervous system. Rheumatic diseases are often chronic and may be progressive, meaning they can worsen over time. They can cause significant pain, disability, and reduced quality of life if not properly diagnosed and managed. The exact causes of rheumatic diseases are not fully understood, but genetics, environmental factors, and immune system dysfunction are believed to play a role in their development.

Cyclic peptides are a type of peptides in which the N-terminus and C-terminus of the peptide chain are linked to form a circular structure. This is in contrast to linear peptides, which have a straight peptide backbone with a free N-terminus and C-terminus. The cyclization of peptides can occur through various mechanisms, including the formation of an amide bond between the N-terminal amino group and the C-terminal carboxylic acid group (head-to-tail cyclization), or through the formation of a bond between side chain functional groups.

Cyclic peptides have unique structural and chemical properties that make them valuable in medical and therapeutic applications. For example, they are more resistant to degradation by enzymes compared to linear peptides, which can increase their stability and half-life in the body. Additionally, the cyclic structure allows for greater conformational rigidity, which can enhance their binding affinity and specificity to target molecules.

Cyclic peptides have been explored as potential therapeutics for a variety of diseases, including cancer, infectious diseases, and neurological disorders. They have also been used as tools in basic research to study protein-protein interactions and cell signaling pathways.

Vasculitis is a group of disorders characterized by inflammation of the blood vessels, which can cause changes in the vessel walls including thickening, narrowing, or weakening. These changes can restrict blood flow, leading to organ and tissue damage. The specific symptoms and severity of vasculitis depend on the size and location of the affected blood vessels and the extent of inflammation. Vasculitis can affect any organ system in the body, and its causes can vary, including infections, autoimmune disorders, or exposure to certain medications or chemicals.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Breast neoplasms refer to abnormal growths in the breast tissue that can be benign or malignant. Benign breast neoplasms are non-cancerous tumors or growths, while malignant breast neoplasms are cancerous tumors that can invade surrounding tissues and spread to other parts of the body.

Breast neoplasms can arise from different types of cells in the breast, including milk ducts, milk sacs (lobules), or connective tissue. The most common type of breast cancer is ductal carcinoma, which starts in the milk ducts and can spread to other parts of the breast and nearby structures.

Breast neoplasms are usually detected through screening methods such as mammography, ultrasound, or MRI, or through self-examination or clinical examination. Treatment options for breast neoplasms depend on several factors, including the type and stage of the tumor, the patient's age and overall health, and personal preferences. Treatment may include surgery, radiation therapy, chemotherapy, hormone therapy, or targeted therapy.

Gram-positive bacterial infections refer to illnesses or diseases caused by Gram-positive bacteria, which are a group of bacteria that turn purple when stained using the Gram stain method. This staining technique is used in microbiology to differentiate between two main types of bacteria based on their cell wall composition.

Gram-positive bacteria have a thick layer of peptidoglycan in their cell walls, which retains the crystal violet stain used in the Gram staining process. Some common examples of Gram-positive bacteria include Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis.

Gram-positive bacterial infections can range from mild skin infections to severe and life-threatening conditions such as pneumonia, meningitis, and sepsis. The symptoms of these infections depend on the type of bacteria involved and the location of the infection in the body. Treatment typically involves the use of antibiotics that are effective against Gram-positive bacteria, such as penicillin, vancomycin, or clindamycin. However, the emergence of antibiotic resistance among Gram-positive bacteria is a growing concern and can complicate treatment in some cases.

Antineoplastic agents, hormonal, are a class of drugs used to treat cancers that are sensitive to hormones. These agents work by interfering with the production or action of hormones in the body. They can be used to slow down or stop the growth of cancer cells and may also help to relieve symptoms caused by the spread of cancer.

Hormonal therapies can work in one of two ways: they can either block the production of hormones or prevent their action on cancer cells. For example, some hormonal therapies work by blocking the action of estrogen or testosterone, which are hormones that can stimulate the growth of certain types of cancer cells.

Examples of hormonal agents used to treat cancer include:

* Aromatase inhibitors (such as letrozole, anastrozole, and exemestane), which block the production of estrogen in postmenopausal women
* Selective estrogen receptor modulators (such as tamoxifen and raloxifene), which block the action of estrogen on cancer cells
* Luteinizing hormone-releasing hormone agonists (such as leuprolide, goserelin, and triptorelin), which block the production of testosterone in men
* Antiandrogens (such as bicalutamide, flutamide, and enzalutamide), which block the action of testosterone on cancer cells

Hormonal therapies are often used in combination with other treatments, such as surgery or radiation therapy. They may be used to shrink tumors before surgery, to kill any remaining cancer cells after surgery, or to help control the spread of cancer that cannot be removed by surgery. Hormonal therapies can also be used to relieve symptoms and improve quality of life in people with advanced cancer.

It's important to note that hormonal therapies are not effective for all types of cancer. They are most commonly used to treat breast, prostate, and endometrial cancers, which are known to be sensitive to hormones. Hormonal therapies may also be used to treat other types of cancer in certain situations.

Like all medications, hormonal therapies can have side effects. These can vary depending on the specific drug and the individual person. Common side effects of hormonal therapies include hot flashes, fatigue, mood changes, and sexual dysfunction. Some hormonal therapies can also cause more serious side effects, such as an increased risk of osteoporosis or blood clots. It's important to discuss the potential risks and benefits of hormonal therapy with a healthcare provider before starting treatment.

Retrospective studies, also known as retrospective research or looking back studies, are a type of observational study that examines data from the past to draw conclusions about possible causal relationships between risk factors and outcomes. In these studies, researchers analyze existing records, medical charts, or previously collected data to test a hypothesis or answer a specific research question.

Retrospective studies can be useful for generating hypotheses and identifying trends, but they have limitations compared to prospective studies, which follow participants forward in time from exposure to outcome. Retrospective studies are subject to biases such as recall bias, selection bias, and information bias, which can affect the validity of the results. Therefore, retrospective studies should be interpreted with caution and used primarily to generate hypotheses for further testing in prospective studies.

Prednisolone is a synthetic glucocorticoid drug, which is a class of steroid hormones. It is commonly used in the treatment of various inflammatory and autoimmune conditions due to its potent anti-inflammatory and immunosuppressive effects. Prednisolone works by binding to specific receptors in cells, leading to changes in gene expression that reduce the production of substances involved in inflammation, such as cytokines and prostaglandins.

Prednisolone is available in various forms, including tablets, syrups, and injectable solutions. It can be used to treat a wide range of medical conditions, including asthma, rheumatoid arthritis, inflammatory bowel disease, allergies, skin conditions, and certain types of cancer.

Like other steroid medications, prednisolone can have significant side effects if used in high doses or for long periods of time. These may include weight gain, mood changes, increased risk of infections, osteoporosis, diabetes, and adrenal suppression. As a result, the use of prednisolone should be closely monitored by a healthcare professional to ensure that its benefits outweigh its risks.

A "Drug Administration Schedule" refers to the plan for when and how a medication should be given to a patient. It includes details such as the dose, frequency (how often it should be taken), route (how it should be administered, such as orally, intravenously, etc.), and duration (how long it should be taken) of the medication. This schedule is often created and prescribed by healthcare professionals, such as doctors or pharmacists, to ensure that the medication is taken safely and effectively. It may also include instructions for missed doses or changes in the dosage.

Osteoarthritis (OA) is a type of joint disease that is characterized by the breakdown and eventual loss of cartilage - the tissue that cushions the ends of bones where they meet in the joints. This breakdown can cause the bones to rub against each other, causing pain, stiffness, and loss of mobility. OA can occur in any joint, but it most commonly affects the hands, knees, hips, and spine. It is often associated with aging and can be caused or worsened by obesity, injury, or overuse.

The medical definition of osteoarthritis is: "a degenerative, non-inflammatory joint disease characterized by the loss of articular cartilage, bone remodeling, and the formation of osteophytes (bone spurs). It is often associated with pain, stiffness, and decreased range of motion in the affected joint."

Biliary tract diseases refer to a group of medical conditions that affect the biliary system, which includes the gallbladder, bile ducts, and liver. Bile is a digestive juice produced by the liver, stored in the gallbladder, and released into the small intestine through the bile ducts to help digest fats.

Biliary tract diseases can cause various symptoms such as abdominal pain, jaundice, fever, nausea, vomiting, and changes in stool color. Some of the common biliary tract diseases include:

1. Gallstones: Small, hard deposits that form in the gallbladder or bile ducts made up of cholesterol or bilirubin.
2. Cholecystitis: Inflammation of the gallbladder, often caused by gallstones.
3. Cholangitis: Infection or inflammation of the bile ducts.
4. Biliary dyskinesia: A motility disorder that affects the contraction and relaxation of the muscles in the biliary system.
5. Primary sclerosing cholangitis: A chronic autoimmune disease that causes scarring and narrowing of the bile ducts.
6. Biliary tract cancer: Rare cancers that affect the gallbladder, bile ducts, or liver.

Treatment for biliary tract diseases varies depending on the specific condition and severity but may include medications, surgery, or a combination of both.

Dengue is a mosquito-borne viral infection that is primarily transmitted by the Aedes aegypti and Aedes albopictus species of mosquitoes. It is caused by one of four closely related dengue viruses (DENV 1, DENV 2, DENV 3, or DENV 4). The infection can cause a wide range of symptoms, ranging from mild fever and headache to severe flu-like illness, which is often characterized by the sudden onset of high fever, severe headache, muscle and joint pain, nausea, vomiting, and skin rash. In some cases, dengue can progress to more severe forms, such as dengue hemorrhagic fever or dengue shock syndrome, which can be life-threatening if not treated promptly and appropriately.

Dengue is prevalent in many tropical and subtropical regions around the world, particularly in urban and semi-urban areas with poor sanitation and inadequate mosquito control. There is no specific treatment for dengue, and prevention efforts focus on reducing mosquito populations and avoiding mosquito bites. Vaccines are available in some countries to prevent dengue infection, but they are not widely used due to limitations in their effectiveness and safety.

Postmenopause is a stage in a woman's life that follows 12 months after her last menstrual period (menopause) has occurred. During this stage, the ovaries no longer release eggs and produce lower levels of estrogen and progesterone hormones. The reduced levels of these hormones can lead to various physical changes and symptoms, such as hot flashes, vaginal dryness, and mood changes. Postmenopause is also associated with an increased risk of certain health conditions, including osteoporosis and heart disease. It's important for women in postmenopause to maintain a healthy lifestyle, including regular exercise, a balanced diet, and routine medical check-ups to monitor their overall health and manage any potential risks.

Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. It is characterized by persistent inflammation, synovial hyperplasia, and subsequent damage to the articular cartilage and bone. The immune system mistakenly attacks the body's own tissues, specifically targeting the synovial membrane lining the joint capsule. This results in swelling, pain, warmth, and stiffness in affected joints, often most severely in the hands and feet.

RA can also have extra-articular manifestations, affecting other organs such as the lungs, heart, skin, eyes, and blood vessels. The exact cause of RA remains unknown, but it is believed to involve a complex interplay between genetic susceptibility and environmental triggers. Early diagnosis and treatment are crucial in managing rheumatoid arthritis to prevent joint damage, disability, and systemic complications.

Autoantibodies are defined as antibodies that are produced by the immune system and target the body's own cells, tissues, or organs. These antibodies mistakenly identify certain proteins or molecules in the body as foreign invaders and attack them, leading to an autoimmune response. Autoantibodies can be found in various autoimmune diseases such as rheumatoid arthritis, lupus, and thyroiditis. The presence of autoantibodies can also be used as a diagnostic marker for certain conditions.

Immunosuppressive agents are medications that decrease the activity of the immune system. They are often used to prevent the rejection of transplanted organs and to treat autoimmune diseases, where the immune system mistakenly attacks the body's own tissues. These drugs work by interfering with the immune system's normal responses, which helps to reduce inflammation and damage to tissues. However, because they suppress the immune system, people who take immunosuppressive agents are at increased risk for infections and other complications. Examples of immunosuppressive agents include corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, tacrolimus, and sirolimus.

Combination drug therapy is a treatment approach that involves the use of multiple medications with different mechanisms of action to achieve better therapeutic outcomes. This approach is often used in the management of complex medical conditions such as cancer, HIV/AIDS, and cardiovascular diseases. The goal of combination drug therapy is to improve efficacy, reduce the risk of drug resistance, decrease the likelihood of adverse effects, and enhance the overall quality of life for patients.

In combining drugs, healthcare providers aim to target various pathways involved in the disease process, which may help to:

1. Increase the effectiveness of treatment by attacking the disease from multiple angles.
2. Decrease the dosage of individual medications, reducing the risk and severity of side effects.
3. Slow down or prevent the development of drug resistance, a common problem in chronic diseases like HIV/AIDS and cancer.
4. Improve patient compliance by simplifying dosing schedules and reducing pill burden.

Examples of combination drug therapy include:

1. Antiretroviral therapy (ART) for HIV treatment, which typically involves three or more drugs from different classes to suppress viral replication and prevent the development of drug resistance.
2. Chemotherapy regimens for cancer treatment, where multiple cytotoxic agents are used to target various stages of the cell cycle and reduce the likelihood of tumor cells developing resistance.
3. Cardiovascular disease management, which may involve combining medications such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, and statins to control blood pressure, heart rate, fluid balance, and cholesterol levels.
4. Treatment of tuberculosis, which often involves a combination of several antibiotics to target different aspects of the bacterial life cycle and prevent the development of drug-resistant strains.

When prescribing combination drug therapy, healthcare providers must carefully consider factors such as potential drug interactions, dosing schedules, adverse effects, and contraindications to ensure safe and effective treatment. Regular monitoring of patients is essential to assess treatment response, manage side effects, and adjust the treatment plan as needed.

Systemic Scleroderma, also known as Systemic Sclerosis (SSc), is a rare, chronic autoimmune disease that involves the abnormal growth and accumulation of collagen in various connective tissues, blood vessels, and organs throughout the body. This excessive collagen production leads to fibrosis or scarring, which can cause thickening, hardening, and tightening of the skin and damage to internal organs such as the heart, lungs, kidneys, and gastrointestinal tract.

Systemic Scleroderma is characterized by two main features: small blood vessel abnormalities (Raynaud's phenomenon) and fibrosis. The disease can be further classified into two subsets based on the extent of skin involvement: limited cutaneous systemic sclerosis (lcSSc) and diffuse cutaneous systemic sclerosis (dcSSc).

Limited cutaneous systemic sclerosis affects the skin distally, typically involving fingers, hands, forearms, feet, lower legs, and face. It is often associated with Raynaud's phenomenon, calcinosis, telangiectasias, and pulmonary arterial hypertension.

Diffuse cutaneous systemic sclerosis involves more extensive skin thickening and fibrosis that spreads proximally to affect the trunk, upper arms, thighs, and face. It is commonly associated with internal organ involvement, such as interstitial lung disease, heart disease, and kidney problems.

The exact cause of Systemic Scleroderma remains unknown; however, it is believed that genetic, environmental, and immunological factors contribute to its development. There is currently no cure for Systemic Scleroderma, but various treatments can help manage symptoms, slow disease progression, and improve quality of life.

Follow-up studies are a type of longitudinal research that involve repeated observations or measurements of the same variables over a period of time, in order to understand their long-term effects or outcomes. In medical context, follow-up studies are often used to evaluate the safety and efficacy of medical treatments, interventions, or procedures.

In a typical follow-up study, a group of individuals (called a cohort) who have received a particular treatment or intervention are identified and then followed over time through periodic assessments or data collection. The data collected may include information on clinical outcomes, adverse events, changes in symptoms or functional status, and other relevant measures.

The results of follow-up studies can provide important insights into the long-term benefits and risks of medical interventions, as well as help to identify factors that may influence treatment effectiveness or patient outcomes. However, it is important to note that follow-up studies can be subject to various biases and limitations, such as loss to follow-up, recall bias, and changes in clinical practice over time, which must be carefully considered when interpreting the results.

The adrenal cortex hormones are a group of steroid hormones produced and released by the outer portion (cortex) of the adrenal glands, which are located on top of each kidney. These hormones play crucial roles in regulating various physiological processes, including:

1. Glucose metabolism: Cortisol helps control blood sugar levels by increasing glucose production in the liver and reducing its uptake in peripheral tissues.
2. Protein and fat metabolism: Cortisol promotes protein breakdown and fatty acid mobilization, providing essential building blocks for energy production during stressful situations.
3. Immune response regulation: Cortisol suppresses immune function to prevent overactivation and potential damage to the body during stress.
4. Cardiovascular function: Aldosterone regulates electrolyte balance and blood pressure by promoting sodium reabsorption and potassium excretion in the kidneys.
5. Sex hormone production: The adrenal cortex produces small amounts of sex hormones, such as androgens and estrogens, which contribute to sexual development and function.
6. Growth and development: Cortisol plays a role in normal growth and development by influencing the activity of growth-promoting hormones like insulin-like growth factor 1 (IGF-1).

The main adrenal cortex hormones include:

1. Glucocorticoids: Cortisol is the primary glucocorticoid, responsible for regulating metabolism and stress response.
2. Mineralocorticoids: Aldosterone is the primary mineralocorticoid, involved in electrolyte balance and blood pressure regulation.
3. Androgens: Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant adrenal androgens, contributing to sexual development and function.
4. Estrogens: Small amounts of estrogens are produced by the adrenal cortex, mainly in women.

Disorders related to impaired adrenal cortex hormone production or regulation can lead to various clinical manifestations, such as Addison's disease (adrenal insufficiency), Cushing's syndrome (hypercortisolism), and congenital adrenal hyperplasia (CAH).

Peripheral Nervous System (PNS) diseases, also known as Peripheral Neuropathies, refer to conditions that affect the functioning of the peripheral nervous system, which includes all the nerves outside the brain and spinal cord. These nerves transmit signals between the central nervous system (CNS) and the rest of the body, controlling sensations, movements, and automatic functions such as heart rate and digestion.

PNS diseases can be caused by various factors, including genetics, infections, toxins, metabolic disorders, trauma, or autoimmune conditions. The symptoms of PNS diseases depend on the type and extent of nerve damage but often include:

1. Numbness, tingling, or pain in the hands and feet
2. Muscle weakness or cramps
3. Loss of reflexes
4. Decreased sensation to touch, temperature, or vibration
5. Coordination problems and difficulty with balance
6. Sexual dysfunction
7. Digestive issues, such as constipation or diarrhea
8. Dizziness or fainting due to changes in blood pressure

Examples of PNS diseases include Guillain-Barre syndrome, Charcot-Marie-Tooth disease, diabetic neuropathy, and peripheral nerve injuries. Treatment for these conditions varies depending on the underlying cause but may involve medications, physical therapy, lifestyle changes, or surgery.

Carboplatin is a chemotherapeutic agent used to treat various types of cancers, including ovarian, lung, and head and neck cancer. It is a platinum-containing compound that works by forming crosslinks in DNA, which leads to the death of rapidly dividing cells, such as cancer cells. Carboplatin is often used in combination with other chemotherapy drugs and is administered intravenously.

The medical definition of Carboplatin is:

"A platinum-containing antineoplastic agent that forms crosslinks with DNA, inducing cell cycle arrest and apoptosis. It is used to treat a variety of cancers, including ovarian, lung, and head and neck cancer."

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that can affect almost any organ or system in the body. In SLE, the immune system produces an exaggerated response, leading to the production of autoantibodies that attack the body's own cells and tissues, causing inflammation and damage. The symptoms and severity of SLE can vary widely from person to person, but common features include fatigue, joint pain, skin rashes (particularly a "butterfly" rash across the nose and cheeks), fever, hair loss, and sensitivity to sunlight.

Systemic lupus erythematosus can also affect the kidneys, heart, lungs, brain, blood vessels, and other organs, leading to a wide range of symptoms such as kidney dysfunction, chest pain, shortness of breath, seizures, and anemia. The exact cause of SLE is not fully understood, but it is believed to involve a combination of genetic, environmental, and hormonal factors. Treatment typically involves medications to suppress the immune system and manage symptoms, and may require long-term management by a team of healthcare professionals.

Antineoplastic agents are a class of drugs used to treat malignant neoplasms or cancer. These agents work by inhibiting the growth and proliferation of cancer cells, either by killing them or preventing their division and replication. Antineoplastic agents can be classified based on their mechanism of action, such as alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic inhibitors, and targeted therapy agents.

Alkylating agents work by adding alkyl groups to DNA, which can cause cross-linking of DNA strands and ultimately lead to cell death. Antimetabolites interfere with the metabolic processes necessary for DNA synthesis and replication, while topoisomerase inhibitors prevent the relaxation of supercoiled DNA during replication. Mitotic inhibitors disrupt the normal functioning of the mitotic spindle, which is essential for cell division. Targeted therapy agents are designed to target specific molecular abnormalities in cancer cells, such as mutated oncogenes or dysregulated signaling pathways.

It's important to note that antineoplastic agents can also affect normal cells and tissues, leading to various side effects such as nausea, vomiting, hair loss, and myelosuppression (suppression of bone marrow function). Therefore, the use of these drugs requires careful monitoring and management of their potential adverse effects.

Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.

IgG has several important functions:

1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.

IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

A cohort study is a type of observational study in which a group of individuals who share a common characteristic or exposure are followed up over time to determine the incidence of a specific outcome or outcomes. The cohort, or group, is defined based on the exposure status (e.g., exposed vs. unexposed) and then monitored prospectively to assess for the development of new health events or conditions.

Cohort studies can be either prospective or retrospective in design. In a prospective cohort study, participants are enrolled and followed forward in time from the beginning of the study. In contrast, in a retrospective cohort study, researchers identify a cohort that has already been assembled through medical records, insurance claims, or other sources and then look back in time to assess exposure status and health outcomes.

Cohort studies are useful for establishing causality between an exposure and an outcome because they allow researchers to observe the temporal relationship between the two. They can also provide information on the incidence of a disease or condition in different populations, which can be used to inform public health policy and interventions. However, cohort studies can be expensive and time-consuming to conduct, and they may be subject to bias if participants are not representative of the population or if there is loss to follow-up.

An acute disease is a medical condition that has a rapid onset, develops quickly, and tends to be short in duration. Acute diseases can range from minor illnesses such as a common cold or flu, to more severe conditions such as pneumonia, meningitis, or a heart attack. These types of diseases often have clear symptoms that are easy to identify, and they may require immediate medical attention or treatment.

Acute diseases are typically caused by an external agent or factor, such as a bacterial or viral infection, a toxin, or an injury. They can also be the result of a sudden worsening of an existing chronic condition. In general, acute diseases are distinct from chronic diseases, which are long-term medical conditions that develop slowly over time and may require ongoing management and treatment.

Examples of acute diseases include:

* Acute bronchitis: a sudden inflammation of the airways in the lungs, often caused by a viral infection.
* Appendicitis: an inflammation of the appendix that can cause severe pain and requires surgical removal.
* Gastroenteritis: an inflammation of the stomach and intestines, often caused by a viral or bacterial infection.
* Migraine headaches: intense headaches that can last for hours or days, and are often accompanied by nausea, vomiting, and sensitivity to light and sound.
* Myocardial infarction (heart attack): a sudden blockage of blood flow to the heart muscle, often caused by a buildup of plaque in the coronary arteries.
* Pneumonia: an infection of the lungs that can cause coughing, chest pain, and difficulty breathing.
* Sinusitis: an inflammation of the sinuses, often caused by a viral or bacterial infection.

It's important to note that while some acute diseases may resolve on their own with rest and supportive care, others may require medical intervention or treatment to prevent complications and promote recovery. If you are experiencing symptoms of an acute disease, it is always best to seek medical attention to ensure proper diagnosis and treatment.

Anti-inflammatory agents are a class of drugs or substances that reduce inflammation in the body. They work by inhibiting the production of inflammatory mediators, such as prostaglandins and leukotrienes, which are released during an immune response and contribute to symptoms like pain, swelling, redness, and warmth.

There are two main types of anti-inflammatory agents: steroidal and nonsteroidal. Steroidal anti-inflammatory drugs (SAIDs) include corticosteroids, which mimic the effects of hormones produced by the adrenal gland. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a larger group that includes both prescription and over-the-counter medications, such as aspirin, ibuprofen, naproxen, and celecoxib.

While both types of anti-inflammatory agents can be effective in reducing inflammation and relieving symptoms, they differ in their mechanisms of action, side effects, and potential risks. Long-term use of NSAIDs, for example, can increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. Corticosteroids can have significant side effects as well, particularly with long-term use, including weight gain, mood changes, and increased susceptibility to infections.

It's important to use anti-inflammatory agents only as directed by a healthcare provider, and to be aware of potential risks and interactions with other medications or health conditions.

Anti-bacterial agents, also known as antibiotics, are a type of medication used to treat infections caused by bacteria. These agents work by either killing the bacteria or inhibiting their growth and reproduction. There are several different classes of anti-bacterial agents, including penicillins, cephalosporins, fluoroquinolones, macrolides, and tetracyclines, among others. Each class of antibiotic has a specific mechanism of action and is used to treat certain types of bacterial infections. It's important to note that anti-bacterial agents are not effective against viral infections, such as the common cold or flu. Misuse and overuse of antibiotics can lead to antibiotic resistance, which is a significant global health concern.

... (from Greek arthro-, joint + -algos, pain) literally means joint pain. Specifically, arthralgia is a symptom of ... The causes of arthralgia are varied and range, from a joints perspective, from degenerative and destructive processes such as ... According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" ... When attempting to establish the cause of the arthralgia, the emphasis is on the interview. The patient is asked questions ...
section 3-11.2 Compression Arthralgia. Campbell, Ernest (10 June 2010). "Compression arthralgia". Scubadoc's Diving Medicine ... Compression arthralgia is pain in the joints caused by exposure to high ambient pressure at a relatively high rate of ... Compression arthralgia has been recorded as deep aching pain in the knees, shoulders, fingers, back, hips, neck and ribs. Pain ... Compression arthralgia is generally a problem of deep diving, particularly deep saturation diving, where at sufficient depth ...
"Arthralgia Definition". MedicineNet.com. Archived from the original on 11 October 2007. Retrieved 2007-09-20. Joe G. Hardin. " ... "Arthralgia". Clinical Methods - The History, Physical, and Laboratory Examinations. Retrieved 2007-09-20. "Overview of Bone ...
... arthralgia; and zinc deficiency, with the latter being a problem especially for individuals with diabetes. Deferasirox is an N- ...
Compression arthralgia is a deep aching pain in the joints caused by exposure to high ambient pressure at a relatively high ... Compression arthralgia is generally a problem of deep diving, particularly deep saturation diving, where at sufficient depth ... Compression arthralgia may be easily distinguished from decompression sickness as it starts during descent, is present before ... Compression or blowdown to storage depth is generally at a limited rate to minimize the risk of HPNS and compression arthralgia ...
Compression arthralgia is pain in the joints caused by exposure to high ambient pressure at a relatively high rate of ... Compression arthralgia is generally a problem of deep diving, particularly deep saturation diving, where at sufficient depth ... Campbell, Ernest (10 June 2010). "Compression arthralgia". Scubadoc's Diving Medicine Online. Retrieved 29 November 2013. ...
ISBN 978-0-7020-2571-6. Campbell, Ernest (10 June 2010). "Compression arthralgia". Scubadoc's Diving Medicine Online. Retrieved ... Compression arthralgia is pain in the joints caused by exposure to high ambient pressure at a relatively high rate of ...
Role in memory and learning Role in arthralgia. Role in Alzheimer's disease. Smooth muscle contraction in the gut. Probable ... Passier A, van Puijenbroek E (November 2005). "Mirtazapine-induced arthralgia". British Journal of Clinical Pharmacology. 60 (5 ...
Fever (50%); arthralgia or arthritis (62%); eye involvement, most frequently conjunctivitis or iridocyclitis (38%); and oral ... Seventeen of 18 patients had a good initial response; fever and arthralgias were markedly attenuated within 48 hours, and ...
True serum sickness, a type III hypersensitivity reaction, results in fever, lymphadenopathy, arthralgias, cutaneous eruptions ... arthralgias; myalgias; and mild proteinuria. Case reports have noted the absence of fever in serum sickness-like reactions to ... and high doses of H1 and H2 antihistamines help resolve the arthralgias and myalgias within 24 hours and the remaining symptoms ...
Arthralgias and myalgias; Tests used to diagnose Sjögren syndrome include: tear break-up time and Schirmer's tests a minor ...
Arthralgia Myopathy Myositis "Dolores musculares: MedlinePlus enciclopedia médica". medlineplus.gov (in Spanish). Retrieved ...
Ariaans, Maud (February 2017). "Fever and arthralgia after 'volcano boarding' in Nicaragua". Travel Medicine and Infectious ...
joint pain (arthralgia), especially in finger and toe joints. fever, usually appears before rash. This may be as high as 40 °C ...
2007). "Two cases with pachydermoperiostosis and discussion of tamoxifen citrate treatment for arthralgia". Rheumatol Clin. 26 ... arthralgia and gastrointestinal abnormalities. An overview of all symptoms is provided in table 2. Table 2. Overview of signs ...
It is characterized by fever, myalgia, headache, and arthralgia. Sometimes it develops in a life-threatening reaction of the ...
Symptoms include fever, malaise, rash, arthralgia, and muscle tenderness. Fever and malaise generally disappear within a few ...
"Chronic fatigue syndrome and arthralgia following parvovirus B19 infection". The Journal of Rheumatology. 29 (3): 595-602. PMID ...
This includes relieving arthralgia, swollen knees, and foot pain. Treatment of these conditions can involve combinations such ...
... the symptoms include arthralgia, rash and malaise. Sindbis virus is widely and continuously found in insects and vertebrates in ...
From the side of the musculoskeletal system: arthralgia, myalgia. Allergic reactions: pruritus, urticaria, angioedema, ...
Inbred mice infected with RRV develop hind-limb arthritis/arthralgia. The disease in mice, similar to humans, is characterised ... In 1943, several outbreaks of arthralgia and arthritis were described in the Northern Territory, Queensland and the Schouten ...
The triad consists of: palpable purpura arthralgia (joint pain) weakness. "Cryoglobulinaemia. Free medical information. Patient ...
Other minor Jones Criteria are fever, elevated ESR and arthralgia. One of the most serious complications is pancarditis, or ...
Symptoms include fever, myalgias, arthralgias and headache. Miscarriage, stillbirth and preterm labor are complications of this ...
In addition to all of the above, primidone can cause arthralgia. Granulocytopenia, agranulocytosis, red-cell hypoplasia and ...
Myalgia (muscular pain) and arthralgia (joint pain) are rare side effects. Retinoids, such as high dose etretinate, are well ...
... vertigo or arthralgia. Occasionally the patient may present with a feeling of protrusion of one or both eyeballs (exophthalmos ...
2006). "Arthralgia of the temporomandibular joint and low-level laser therapy". Photomedicine and Laser Surgery. 24 (4): 522- ...
There are often associated systemic symptoms of fever, malaise, and arthralgia. The thyrotoxic phase can last for 3-6 weeks ...
Arthralgia (from Greek arthro-, joint + -algos, pain) literally means joint pain. Specifically, arthralgia is a symptom of ... The causes of arthralgia are varied and range, from a joints perspective, from degenerative and destructive processes such as ... According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" ... When attempting to establish the cause of the arthralgia, the emphasis is on the interview. The patient is asked questions ...
Considering taking a vitamin or supplement to treat Paclitaxel-Induced+Myalgia And Arthralgia? Below is a list of common ... natural remedies used to treat or reduce the symptoms of Paclitaxel-Induced+Myalgia And Arthralgia. Follow the links to read ...
... Ned Tijdschr Geneeskd. 1995 Apr ... Objective: To determine the characteristics and the course of chronic arthralgia (CA) and the differences from newly diagnosed ...
In these cases, presentation with arthralgia in young adulthood, low hepcidin/ferritin ratio and/or liver iron content , 100 ... TFR2-related haemochromatosis in the Netherlands: a cause of arthralgia in young adulthood Neth J Med. 2017 Mar;75(2):56-64. ... Results: Three women and one man diagnosed with HH type 3 presented with arthralgia and elevated ferritin levels and ... In these cases, presentation with arthralgia in young adulthood, low hepcidin/ferritin ratio and/or liver iron content , 100 ...
A news site about health science, human physiology, and nutrition, with a focus on alternative medicine and life extension ...
A prediction rule for the development of arthritis in seropositive arthralgia patients ... A prediction rule for the development of arthritis in seropositive arthralgia patients ... A prediction rule for the development of arthritis in seropositive arthralgia patients ...
Learn more about Arthralgia causes, sign and symptoms, treatment and diagnosis at FindaTopdoc. Read more information on ... 1 What is arthralgia?. In the most literal sense, arthralgia refers to any sort of joint pain. The word "arthralgia" came into ... 2 Symptoms of arthralgia. Arthralgia causes non-inflammatory joint pain. A person can experience this pain in just one area or ... 8 Risks and complications associated with arthralgia. Arthralgia is a serious issue; if left untreated, it could turn an ...
Lindsey, Nicole "Chronic arthralgia after chikungunya" 20230108 (2022). Lindsey, Nicole "Chronic arthralgia after chikungunya" ... Title : Chronic arthralgia after chikungunya Personal Author(s) : Lindsey, Nicole Corporate Authors(s) : United States. ...
... ... Chikungunya Fever; Cohort Studies; Risk Groups; Arthralgia; Chronic Pain; Mexico; Fiebre Chikungunya; Estudios de Cohortes; ... Our findings may be useful in health care settings to stratify the risk of chronic arthralgia secondary to CHIKV infection and ... Participants were interviewed at 6 months from the onset of symptoms, and self-reported persistent arthralgia (PA) was the main ...
The troublesome side-effect of arthralgia remains a distinct clinical problem, with limited data on its aetiology and ... management and the need for guidelines for aromatase inhibitor-induced arthralgia (AIA). RESULTS: Four hundred and sixteen (54 ... Current opinion of aromatase inhibitor-induced arthralgia in breast cancer in the UK. ... The troublesome side-effect of arthralgia remains a distinct clinical problem, with limited data on its aetiology and ...
Arthralgia Symptom Checker: Possible causes include Post-COVID-19. Check the full list of possible causes and conditions now! ... Arthralgia and myalgia are the common manifestations in type II and III syndrome. Arthralgia often affect joints of hands, ... Syphilis arthralgia (arthralgia syphilitica). Can meet soon after syphilis infection in the second and third period. [ ... High ASO titers, arthralgia, and combination of high ASO titers with arthralgia are the main presenting symptoms in the group ...
Arthralgia. Though rare, severe and disabling joint pain (arthralgia) can occur days to years after starting Onglyza. ...
14-3-3η was detectable prior to the onset of arthritis and was associated with arthritis development in arthralgia subjects pre ... the association of 14-3-3η with the development of clinically apparent arthritis in a cohort of subjects with arthralgia and ... A prospective cohort study of 14-3-3η in ACPA and/or RF-positive patients with arthralgia. *Marian H. van Beers-Tas. 1, ... Distribution of positivity for ACPA, RF and 14-3-3η in a cohort of arthralgia patients. Top panel: different combinations of ...
Arthralgia and arthritis are very similar but not quite the same. Lets look at the differences between these two causes of ... What Causes Arthralgia?. Because arthralgia just means "joint pain," its a much more general term than arthritis. Arthralgia ... What Can Help Arthralgia and Arthritis?. You can use many medical interventions to address arthralgia and arthritis, and some ... How Is Arthralgia Different From Arthritis?. Oftentimes, people use arthritis and arthralgia interchangeably, but they are not ...
Arthralgia / Joint pain Pain that comes along with Arthralgia has a wide range from light till very intense and can... ... Arthralgia/Joint Pain. Arthralgia is a moderate till serious pain in one or multiple joints. The pain can be described as sharp ... Arthralgia is a moderate till serious pain in one or multiple joints. Interventional pain management treatments may help to ...
TITLE Neuromodulation Treats Chikungunya Arthralgia SOURCE Scientific Reports. 8(1):16010, 2018 10 30. AUTHORS Silva-Filho E; ... More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. There are no ... including diffuse neuromuscular pain and arthralgia. Here, we demonstrate that the tDCS across the primary motor cortex ...
Dorzolamide hydrochloride-timolol maleate Related Arthralgia seen in social media and in the FDA adverse event database. ...
The phenotype of acid sphingomyelinase deficiency (ASMD) occurs along a continuum. Individuals with the severe early-onset form, infantile neurovisceral ASMD, were historically diagnosed with Niemann-Pick disease type A (NPD-A). The later-onset, chronic visceral form of ASMD is also referred to as Niemann-Pick disease type B (NPD-B). A phenotype with intermediate severity is also known as chronic neurovisceral ASMD (NPD-A/B). The most common presenting symptom in NPD-A is hepatosplenomegaly, usually detectable by age three months; over time the liver and spleen become massive in size. Psychomotor development progresses no further than the 12-month level, after which neurologic deterioration is relentless. Failure to thrive typically becomes evident by the second year of life. A classic cherry-red spot of the macula of the retina, which may not be present in the first few months, is eventually present in all affected children. Interstitial lung disease caused by storage of sphingomyelin in ...
... body ache/arthralgia, headache etc. Composition: Each 1ml. Contains Cinchona Officinalis 10X 0.02% v/v, Aconitum Napellus 8X ...
Rheumatoid arthritis prevention in arthralgia: fantasy or reality? *Hanna W. van Steenbergen ... Rheumatoid arthritis prevention in arthralgia: fantasy or reality? *Hanna W. van Steenbergen ...
Arthralgias/arthropathies. These occur in up to 10% of pediatric patients and up to 50% of adult patients. Arthropathy usually ... and arthralgia, along with topical antipruritics and antihistamines (which also relieve pruritus). Treatment also includes ...
Calcaneal Cuboid Joint Arthralgia is characterized by pain in the calcaneal cuboid joint and is normally treated with a ... Unlike arthritis, in arthralgia x-rays do not reveal show visible signs of joint space narrowing, cyst formation within the ... During normal walking there are very high compressive and tension loads in this region of the foot which can lead to arthralgia ... The pain associated with Calcaneal Cuboid Joint Arthralgia is generally experienced with initial weight bearing after prolonged ...
Cardiovascular symptoms Chest pains Cough Diarrhoea Fever Headaches Joint pain (arthralgia) Loss of smell or taste Muscle aches ... Cardiovascular symptoms Chest pains Cough Fever Joint pain (arthralgia) Loss of smell or taste Muscle aches (myalgia) ... Chest pains Joint pain (arthralgia) Loss of smell or taste Muscle aches (myalgia) Neurological symptoms Respiratory symptoms ... Cough Fever Headaches Joint pain (arthralgia) Muscle aches (myalgia) Neurological symptoms Respiratory symptoms Severe fatigue ...
Arthralgias and arthritis. Acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) can be taken for arthralgias. ... 89] Several smaller studies of rituximab revealed improvement of arthralgias, regression of parotid gland swelling, [90] and ...
Arthralgia: Severe and disabling arthralgia has been reported in patients taking TRADJENTA. Consider as a possible cause for ... 5.4 Severe and Disabling Arthralgia. There have been postmarketing reports of severe and disabling arthralgia in patients ... 5.4 Severe and Disabling Arthralgia 5.5 Bullous Pemphigoid 5.6 Heart Failure 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience ... Severe and Disabling Arthralgia Inform patients that severe and disabling joint pain may occur with this class of drugs. The ...
5.6 Severe and Disabling Arthralgia. There have been postmarketing reports of severe and disabling arthralgia in patients ... Severe and Disabling Arthralgia [see Warnings and Precautions (5.6)] •. Bullous Pemphigoid [see Warnings and Precautions (5.7)] ... 5.6 Severe and Disabling Arthralgia 5.7 Bullous Pemphigoid 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 Postmarketing ... Severe and Disabling Arthralgia Inform patients that severe and disabling joint pain may occur with this class of drugs. The ...
These data highlight the need for ruling out Whipples disease in patients with a history of arthralgia prior to initiation of ... A history of rheumatic arthritis or even a transient arthralgia should put Tropheryma whipplei on the top of differentials in ... His past medical history revealed episodes of transient arthralgia, which he was not treated for however, due to the self- ... Both men reported negative history of arthralgia during the one year period post surgery. Tropheryma whipplei culture negative- ...
  • Specifically, arthralgia is a symptom of injury, infection, illness (in particular arthritis), or an allergic reaction to medication. (wikipedia.org)
  • According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. (wikipedia.org)
  • To determine the characteristics and the course of chronic arthralgia (CA) and the differences from newly diagnosed rheumatoid arthritis (RA). (nih.gov)
  • More often than not, arthralgia is a symptom of an infection, injury, or illness such as arthritis , or any consequent allergic reaction to a specific medication. (findatopdoc.com)
  • We analysed the association of 14-3-3η with the development of clinically apparent arthritis in a cohort of subjects with arthralgia and positivity for at least one serologic marker: rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA). (biomedcentral.com)
  • 14-3-3η was detectable prior to the onset of arthritis and was associated with arthritis development in arthralgia subjects pre-selected for positivity of RF or ACPA. (biomedcentral.com)
  • Recently, we published a prediction rule for the development of arthritis in rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) positive (seropositive) arthralgia patients [ 1 ]. (biomedcentral.com)
  • From the Reade seropositive arthralgia cohort, the first 144 participants (with ≥30 months of follow-up or development of arthritis, included between 2004 and 2008) were used. (biomedcentral.com)
  • Let's learn about the different types of joint pain and what separates arthralgia from arthritis. (musclemx.com)
  • How Is Arthralgia Different From Arthritis? (musclemx.com)
  • Oftentimes, people use arthritis and arthralgia interchangeably, but they are not quite the same thing. (musclemx.com)
  • With this in mind, arthritis indicates inflammation in the joints, while arthralgia indicates pain or aching in the joints. (musclemx.com)
  • Often these two terms are used interchangeably, but arthritis refers specifically to joint inflammation, while arthralgia refers to joint pain in general or joint pain that is not a result of inflammation. (musclemx.com)
  • While gout is a type of arthritis, it can cause pain that isn't directly due to inflammation, so it can also cause arthralgia. (musclemx.com)
  • Because arthralgia just means "joint pain," it's a much more general term than arthritis. (musclemx.com)
  • While many of these could be caused by an early onset of arthritis, arthralgia is generally recognized as a symptom, not a condition, so there's no test to determine if you have it - you either feel pain in your joints or you don't. (musclemx.com)
  • What Can Help Arthralgia and Arthritis? (musclemx.com)
  • You can use many medical interventions to address arthralgia and arthritis, and some home remedies can ease discomfort for both. (musclemx.com)
  • The type of intervention that your healthcare provider will recommend will depend on what kind of arthritis or arthralgia you're experiencing and what the root cause is. (musclemx.com)
  • Rheumatoid arthritis prevention in arthralgia: fantasy or reality? (nature.com)
  • Unlike arthritis, in arthralgia x-rays do not reveal show visible signs of joint space narrowing, cyst formation within the bone as well as bone spurring. (slomotionshoes.com)
  • A history of rheumatic arthritis or even a transient arthralgia should put Tropheryma whipplei on the top of differentials in patients of this age group presenting with culture-negative infective endocarditis, especially in cases of therapy resistance to antirheumatic agents. (biomedcentral.com)
  • These data highlight the need for ruling out Whipple's disease in patients with a history of arthralgia prior to initiation of biological agents in treatment of rheumatoid arthritis. (biomedcentral.com)
  • supplement to your biologics license application (BLA) for Human Papillomavirus Quadrivalent (Types 6, 11, 16 and 18) Vaccine, Recombinant (GARDASIL), to include arthralgia, myalgia, asthenia, fatigue, and malaise in the Adverse Reactions section of the package insert. (wikipedia.org)
  • Considering taking a vitamin or supplement to treat Paclitaxel-Induced+Myalgia And Arthralgia? (webmd.com)
  • Below is a list of common natural remedies used to treat or reduce the symptoms of Paclitaxel-Induced+Myalgia And Arthralgia. (webmd.com)
  • Other: Arthralgia, Myalgia. (cdc.gov)
  • Epidemic polyarthritis is seen for IL-1RA, IL-2, IL-5, IL-10, IL-12p70, IL-17, gran- a self-limiting febrile arthralgia syndrome that closely re- ulocyte colony-stimulating factor, monocyte chemotactic sembles chikungunya and Mayaro fever. (cdc.gov)
  • Information about Dr. Johns J-19 Malaria Drop Indications: Useful for the malaria symptoms cyclic occurrence of chills (shivering) & fever, sweating, nausea, body ache/arthralgia, headache etc. (kayawell.com)
  • [ 8 ] Symptomatic relief of erythema infectiosum may be provided using nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve fever, malaise, headache, and arthralgia, along with topical antipruritics and antihistamines (which also relieve pruritus). (medscape.com)
  • Its mild Dengue-like symptoms include fever, rash, headaches and Arthralgia. (bvsalud.org)
  • Characteristic clinical symptoms include acute fever with initial maculopapular rash, arthralgia and conjunctivitis. (bvsalud.org)
  • Title : Chronic arthralgia after chikungunya Personal Author(s) : Lindsey, Nicole Corporate Authors(s) : United States. (cdc.gov)
  • Our findings may be useful in health care settings to stratify the risk of chronic arthralgia secondary to CHIKV infection and to identify patients who would benefit clinically from early medical intervention. (paho.org)
  • More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. (tmssolutions.com)
  • Clinical trials indicate transcranial direct current stimulation (tDCS) can treat a broad range of chronic pain disorders, including diffuse neuromuscular pain and arthralgia. (tmssolutions.com)
  • Severe and disabling arthralgia has been reported in patients taking TRADJENTA. (nih.gov)
  • We present two unusual cases of culture-negative infective endocarditis encountered in two different patients with prior history of arthralgia. (biomedcentral.com)
  • Objective: To evaluate through a preliminary study the effectiveness of unsaponifiable soy and avocado (ASU) in patients with arthralgia and osteoarthritis (OA) of the TMJ Patients and Methods: This was a randomized, double-blind, placebo-controlled trial. (bvsalud.org)
  • Conclusions: Even in the case of a preliminary study, this research provides strong evidence of the effectiveness of the ISA in patients with degenerative diseases and TMJ arthralgia, so further research with larger samples should be performed. (bvsalud.org)
  • Joint effusions are common, and arthralgia can be prominent clinical symptom of RRV infection is long-lasting long-lasting (months to years), and recurring. (cdc.gov)
  • To estimate the cumulative incidence of persistent arthralgia at 6 months from acute Chikungunya virus (CHIKV) infection and to evaluate the association of clinical markers with the risk of long-term arthralgia. (paho.org)
  • The troublesome side-effect of arthralgia remains a distinct clinical problem, with limited data on its aetiology and management. (ox.ac.uk)
  • Tropheryma whipplei culture negative-infective endocarditis is an emerging clinical entity, predominantly found in middle-aged and older men with a history of arthralgia. (biomedcentral.com)
  • Arthralgia (from Greek arthro-, joint + -algos, pain) literally means joint pain. (wikipedia.org)
  • The causes of arthralgia are varied and range, from a joints perspective, from degenerative and destructive processes such as osteoarthritis and sports injuries to inflammation of tissues surrounding the joints, such as bursitis. (wikipedia.org)
  • However, the causes of arthralgia are more varied and can be triggered by several things such as vaccinations or by destructive and degenerative processes such as osteoarthritis , sport injuries, or inflammation of the tissues surrounding the joints experiencing pain, as occurs with bursitis . (findatopdoc.com)
  • Arthralgia is a moderate till serious pain in one or multiple joints. (ocp.ae)
  • Acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) can be taken for arthralgias. (medscape.com)
  • Participants were interviewed at 6 months from the onset of symptoms, and self-reported persistent arthralgia (PA) was the main binary outcome. (paho.org)
  • Current opinion of aromatase inhibitor-induced arthralgia in breast cancer in the UK. (ox.ac.uk)
  • In the most literal sense, arthralgia refers to any sort of joint pain . (findatopdoc.com)
  • Phlebotomy decreased the serum iron parameters but did not relieve the arthralgia. (nih.gov)
  • Despite this universal convention, many times inflammatory joint pains are still referred to as arthralgia. (findatopdoc.com)
  • Treatment for arthralgia could possibly worsen the existing joint pain or even cause new pains in other areas. (findatopdoc.com)
  • Arthralgia can feel like generalized pain, aching, or a stiff feeling. (musclemx.com)
  • The pain associated with Calcaneal Cuboid Joint Arthralgia is generally experienced with initial weight bearing after prolonged non weight bearing periods. (slomotionshoes.com)
  • Cooper rheumatologists treat the full spectrum of joint pain (arthralgia) to get you back to living your life. (cooperhealth.org)
  • Three women and one man diagnosed with HH type 3 presented with arthralgia and elevated ferritin levels and transferrin saturation (TSAT) at ages 25-41 years. (nih.gov)
  • The physiology of arthralgia is unclear and thus may include numerous mechanisms depending on the individual and the drug intake. (findatopdoc.com)
  • His past medical history revealed episodes of transient arthralgia, which he was not treated for however, due to the self-limiting nature of the symptoms. (biomedcentral.com)
  • Myalgias and arthralgias associated with paclitaxel. (nih.gov)
  • Other frequent manifestations include severe arthralgias, myalgias, and rash. (medscape.com)
  • These connective tissue effects also produce arthralgias and myalgias, which are some of the most bothersome side effects that patients report. (managinglymphoma.com)
  • 6 Clinical trials of ibrutinib have reported arthralgias and myalgias in 11%-36% of patients. (managinglymphoma.com)
  • 5 While the majority of these arthralgias/myalgias are considered mild or moderate (grade 1-2), these AEs are among the top reasons for discontinuation of ibrutinib. (managinglymphoma.com)
  • 11,12 These advantages extend to arthralgias and myalgias. (managinglymphoma.com)
  • During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. (nih.gov)
  • After the 2014-2015 outbreak of chikungunya virus in the US Virgin Islands, we compared the prevalence of persistent arthralgia among case-patients and controls. (cdc.gov)
  • However, 7%-79% of case-patients from previous outbreaks have reported persistent arthralgia for months after infection ( 4 - 8 ). (cdc.gov)
  • Persistent arthralgia associated with CHIKV illness has been assessed in persons in Southeast Asia, South America, and Europe but not in the Caribbean ( 4 , 9 ). (cdc.gov)
  • To determine the prevalence of CHIKV-associated persistent arthralgia in USVI, we compared the prevalence of persistent arthralgia among CHIKV case-patients and nonsymptomatic controls during December 2014-February 2016. (cdc.gov)
  • We defined persistent arthralgia as joint pain occurring at least once per week within 1 month before the interview. (cdc.gov)
  • In milder cases, Teyder recommends the use of a hand brace as the orthosis of Prot Point Elastic and, for severe arthralgia is necessary to use other hand orthosis adapted to your needs. (teyder.com)
  • The causes of arthralgia are varied and range, from a joints perspective, from degenerative and destructive processes such as osteoarthritis and sports injuries to inflammation of tissues surrounding the joints, such as bursitis. (wikipedia.org)
  • We say, "Go see the rheumatologist," but I'm hoping you could probably elucidate better: how do we pick up if a patient has fibromyalgia or osteoarthritis, these noninflammatory arthralgias, and what can we do about it for the patient? (crohnscolitisprofessional.org)
  • Objective: To evaluate through a preliminary study the effectiveness of unsaponifiable soy and avocado (ASU) in patients with arthralgia and osteoarthritis (OA) of the TMJ Patients and Methods: This was a randomized, double-blind, placebo-controlled trial. (bvsalud.org)
  • Patients often describe arthralgias that are migratory in nature and can sometimes be debilitating. (managinglymphoma.com)
  • Arthralgia is an acute joint pain that may occur suddenly or may be aggravated with the passage of time. (teyder.com)
  • At 6 and 12 months, we interviewed case-patients about presence, frequency, and anatomic location of arthralgia after acute CHIKV infection. (cdc.gov)
  • Arthralgia (from Greek arthro-, joint + -algos, pain) literally means joint pain. (wikipedia.org)
  • Arthralgia treatment depends on the cause of joint pain, so that even though a personalized diagnosis is needed, it is important to relieve joint pain with painkillers or anti-inflammatories other than narcotics, in addition to using appropriate orthosis to avoid aggravating the injury and include therapeutic massages in the treatment of arthralgia. (teyder.com)
  • Seropositive arthralgia is defined as joint pain in patients positive for rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPA). (acrabstracts.org)
  • Conclusions: Even in the case of a preliminary study, this research provides strong evidence of the effectiveness of the ISA in patients with degenerative diseases and TMJ arthralgia, so further research with larger samples should be performed. (bvsalud.org)
  • 6 In this study, the median time to ibrutinib discontinuation for arthralgia was 5 months. (managinglymphoma.com)
  • Baseline macroscopic synovitis and vascularity at arthroscopy were both significantly higher in those who developed RA than in those who remained as seropositive arthralgia, median (IQR) 60 (30, 80) vs 40 (20, 40) mm (p=0.021), and median (IQR) 50 (30, 73) vs 40 (20, 40) mm (p=0.021), Figure 1. (acrabstracts.org)
  • Chikungunya trojan (CHIKV) is a mosquito-borne arthralgia arbovirus that's reemergent in sub-Saharan Africa and Southeast Asia. (cancerrealitycheck.com)
  • Therefore, orthosis are recommended both for prevention as for protection of arthralgia. (teyder.com)
  • Evidence Central , evidence.unboundmedicine.com/evidence/view/infoPOEMs/1314594/all/Acupuncture_may_reduce_aromatase_inhibitor_related_arthralgia_in_women_with_breast_cancer. (unboundmedicine.com)
  • Roughly 40 to 50 percent of people with IBD have arthralgia at some point in their lives. (healthline.com)
  • We're here to help you understand how TMJ arthralgia affects your life and the treatment options at your disposal. (colgate.com)
  • Pretty much every other clinic patient that I see has at some point had some form of arthralgia, and it's i almost eye-opening for them to learn that it could be at all mediated by the gut. (crohnscolitisprofessional.org)