Blastomycosis
Blastomyces
Lung Diseases, Fungal
Central Nervous System Fungal Infections
Histoplasmosis
Wisconsin
Itraconazole
Coccidioidomycosis
Antifungal Agents
Paracoccidioidomycosis
Blastomycosis acquired occupationally during prairie dog relocation--Colorado, 1998. (1/191)
On August 31, 1998, two suspected cases of fungal pneumonia were reported to the Boulder County (Colorado) Health Department (BCHD). Both patients were immunocompetent, otherwise healthy adults working for the City of Boulder Open Space (CBOS) program on a prairie dog relocation project. This report summarizes the epidemiologic investigation by BCHD, the Colorado Department of Public Health and Environment, and CDC; the findings indicate that these two persons acquired blastomycosis in Colorado, which is outside the area where the disease is endemic. (+info)Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis. (2/191)
Systemic fungal infections are becoming more common and difficult to treat, yet the pathogenesis of these infectious diseases remains poorly understood. In many cases, pathogenicity can be attributed to the ability of the fungi to adhere to target tissues, but the lack of tractable genetic systems has limited progress in understanding and interfering with the offending fungal products. In Blastomyces dermatitidis, the agent of blastomycosis, a respiratory and disseminated mycosis of people and animals worldwide, expression of the putative adhesin encoded by the WI-1 gene was investigated as a possible virulence factor. DNA-mediated gene transfer was used to disrupt the WI-1 locus by allelic replacement, resulting in impaired binding and entry of yeasts into macrophages, loss of adherence to lung tissue, and abolishment of virulence in mice; each of these properties was fully restored after reconstitution of WI-1 by means of gene transfer. These findings establish the pivotal role of WI-1 in adherence and virulence of B. dermatitidis yeasts. To our knowledge, they offer the first example of a genetically proven virulence determinant among systemic dimorphic fungi, and underscore the value of reverse genetics for studies of pathogenesis in these organisms. (+info)Endemic mycoses: a treatment update. (3/191)
Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ketoconazole is effective in non-AIDS patients with non-life-threatening histoplasmosis, blastomycosis, or paracoccidioidomycosis. Itraconazole is the treatment of choice for non-life-threatening Histoplasma capsulatum or Blastomyces dermatitidis infections occurring in immunocompetent individuals and is the most efficient secondary prophylaxis of histoplasmosis in AIDS patients. Itraconazole is also effective in lymphocutaneous and visceral sporotrichosis, in paracoccidioidomycosis, for Penicillum marneffei infection, and is an alternative to amphotericin B for Histoplasma duboisii infection. Coccidioidomycosis may be effectively treated with prolonged and sometimes life-long itraconazole or fluconazole therapy. Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials. (+info)Thoracic blastomycosis and empyema. (4/191)
Blastomycosis is endemic in river valley areas of the southeastern and Midwestern United States. Pulmonary manifestations include chronic cough and pleuritic pain. Radiographic appearance of the infection can mimic bronchogenic lung carcinoma. Pleural effusion is rarely associated with this pulmonary infection, and empyema has not been previously reported. We report a case of pulmonary and pleural Blastomyces dermatitidis infection presenting as empyema thoracis. Diagnosis and treatment were attained with video-assisted thoracoscopic (VATS) pleural and lung biopsy and debridement. (+info)Disseminated blastomycosis in a rhesus monkey (Macaca mulatta). (5/191)
An 8-year-old male rhesus monkey (Macaca mulatta) died following a 6-day illness consisting of progressive depression, anorexia, labored abdominal breathing, coughing, and tachypnea. Gross necropsy findings included severe multifocal (miliary) granulomatous pneumonia, granulomatous splenitis, and multifocal cerebral abscesses. Histologic examination revealed 10-15-microm broad-based budding organisms within pyogranulomatous inflammatory lesions in the lung, tracheobronchial lymph node, brain, spleen, and liver. The distribution of extrapulmonary lesions was intermediate between that described for dogs and that described for humans. These findings were consistent with blastomycosis, which is previously unreported in nonhuman primates. (+info)T-Cell epitopes and human leukocyte antigen restriction elements of an immunodominant antigen of Blastomyces dermatitidis. (6/191)
Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display them were investigated. Peripheral blood mononuclear cells (PBMC) from 37 patients with a confirmed history of blastomycosis were tested for a response to WI-1 in primary proliferation assays; PBMC from 35 (95%) responded. Six patients whose PBMC proliferated strongly in response to WI-1 (defined as a stimulation index greater than 50) were tested further for responses to subcloned, recombinant fragments of the antigen. These patients responded chiefly to sequences within the N terminus and the 25-amino-acid tandem repeat. Cloned CD4(+) T cells from an infected individual were used to delineate more precisely the peptide epitopes in the fragments and HLA restricting elements that present them. A majority of the T-cell clones recognized an epitope spanning amino acids 149 to 172 within the N terminus, displayed by HLA-DR 15. A minority of the clones, which have been shown to perform a cytolytic function in vitro, recognized an epitope in the tandem repeat displayed by HLA-DPw4, an uncommon restricting element. Tandem repeat epitopes required display by the beta chain of DPw4 heterodimers. Thus, human T cells with different functions in vitro also recognize distinct regions of WI-1, raising the possibility that HLA restricting elements that present them could modulate immunity during blastomycosis by selection and display of WI-1 peptides. (+info)Jorge Lobo's disease: experimental inoculation in Swiss mice. (7/191)
Sixty-four isogenic Swiss mice were intradermically inoculated in both hind foot pads. The inocula, consisting of fungal suspensions from biopsies obtained from Jorge Lobo's Disease patients, had the total number of fungi and the viability index determined using a Neubauer chamber and the fluorescein diacetate-ethidium bromide technique (FD-EB), respectively. The animals were sacrificed at times ranging from ten days to eighteen months after inoculation. The cellular infiltrate, mainly consisting of macrophages containing fungi, increased progressively up to end of the study; however, no macroscopic alterations were observed in the inoculated feet. After nine months, small numbers of Langhans' giant cells started to appear in the infiltrate. A considerable number of fungi was observed at the end of the experimental period, but only a few were viable when stained by the FD-EB technique. This fact suggests that there is a multiplication of fungal cells, which are destroyed by the macrophages but remain in the tissue for a long time due perhaps to the difficulties in their elimination. These findings led us to conclude that in spite of the maintenance of the infection in these animals, Swiss mice cannot be considered an ideal model to study Jorge Lobo's Disease. However, the authors call attention to the possibility of other mouse strains being more susceptible to Paracoccidioides loboi. (+info)Molecular epidemiology of Blastomyces dermatitidis. (8/191)
The inhalation of conidia of Blastomyces dermatitidis, a fungus found in soil, causes disease in humans and animals. We studied the genetic diversity of this pathogen by extracting DNA yeasts and analyzing them with a polymerase chain reaction (PCR)-based typing system we developed, which used restriction fragment analysis of amplicons from the regions between the rDNA repeats and allowed us to class isolates into 3 major groups. Strains were further differentiated by use of PCR fingerprinting with 3 different primers. Fifty-nine isolates collected over 35 years from 15 regions (United States, India, Africa, Canada) were analyzed. Genotypic groups A, B, and C contained 17, 23, and 19 isolates, which were divided into 5, 15, and 12 types, respectively. All 16 isolates from North America in group A were from the upper midwestern United States or Canada, whereas 0 of 20 isolates from the southeastern United States were in group A. Studies of the largest collection from 1 locale (Eagle River, WI), revealed that the soil isolates studied were not responsible for the majority of cases in this outbreak, as previously proposed, and that >1 strain was present in the environment and in patients. Overall, these results provide a tool for the epidemiological study of blastomycosis and illuminate the genetic and geographic diversity of this important pathogen. (+info)Blastomycosis is a fungal infection caused by the inhalation of spores of the fungus Blastomyces dermatitidis. It primarily affects the lungs but can also spread to other parts of the body, such as the skin, bones, and central nervous system. The initial symptoms of blastomycosis may include cough, fever, chest pain, and difficulty breathing. If left untreated, the infection can become severe and potentially life-threatening. Treatment typically involves antifungal medications, such as itraconazole or amphotericin B.
"Blastomyces" is a genus of fungi that can cause a pulmonary or systemic infection known as blastomycosis in humans and animals. The fungus exists in the environment, particularly in damp soil and decomposing organic matter, and is typically found in certain regions of North America. Infection occurs when a person inhales spores of the fungus, which can lead to respiratory symptoms such as cough, fever, and chest pain. The infection can also disseminate to other parts of the body, causing various symptoms depending on the organs involved.
Fungal lung diseases, also known as fungal pneumonia or mycoses, refer to a group of respiratory disorders caused by the infection of fungi in the lungs. These fungi are commonly found in the environment, such as soil, decaying organic matter, and contaminated materials. People can develop lung diseases from fungi after inhaling spores or particles that contain fungi.
There are several types of fungal lung diseases, including:
1. Aspergillosis: This is caused by the Aspergillus fungus and can affect people with weakened immune systems. It can cause allergic reactions, lung infections, or invasive aspergillosis, which can spread to other organs.
2. Cryptococcosis: This is caused by the Cryptococcus fungus and is usually found in soil contaminated with bird droppings. It can cause pneumonia, meningitis, or skin lesions.
3. Histoplasmosis: This is caused by the Histoplasma capsulatum fungus and is commonly found in the Ohio and Mississippi River valleys. It can cause flu-like symptoms, lung infections, or disseminated histoplasmosis, which can spread to other organs.
4. Blastomycosis: This is caused by the Blastomyces dermatitidis fungus and is commonly found in the southeastern and south-central United States. It can cause pneumonia, skin lesions, or disseminated blastomycosis, which can spread to other organs.
5. Coccidioidomycosis: This is caused by the Coccidioides immitis fungus and is commonly found in the southwestern United States. It can cause flu-like symptoms, lung infections, or disseminated coccidioidomycosis, which can spread to other organs.
Fungal lung diseases can range from mild to severe, depending on the type of fungus and the person's immune system. Treatment may include antifungal medications, surgery, or supportive care. Prevention measures include avoiding exposure to contaminated soil or dust, wearing protective masks in high-risk areas, and promptly seeking medical attention if symptoms develop.
Central nervous system (CNS) fungal infections refer to invasive fungal diseases that affect the brain and/or spinal cord. These types of infections are relatively uncommon but can be serious and potentially life-threatening, especially in individuals with weakened immune systems due to conditions such as HIV/AIDS, cancer, or organ transplantation.
There are several types of fungi that can cause CNS infections, including:
1. Candida species: These are yeast-like fungi that can cause a range of infections, from superficial to systemic. When they invade the CNS, they can cause meningitis or brain abscesses.
2. Aspergillus species: These are mold-like fungi that can cause invasive aspergillosis, which can affect various organs, including the brain.
3. Cryptococcus neoformans: This is a yeast-like fungus that primarily affects people with weakened immune systems. It can cause meningitis or brain abscesses.
4. Coccidioides species: These are mold-like fungi that can cause coccidioidomycosis, also known as Valley Fever. While most infections are limited to the lungs, some people may develop disseminated disease, which can affect the CNS.
5. Histoplasma capsulatum: This is a mold-like fungus that causes histoplasmosis, which primarily affects the lungs but can disseminate and involve the CNS.
Symptoms of CNS fungal infections may include headache, fever, altered mental status, seizures, stiff neck, and focal neurologic deficits. Diagnosis typically involves a combination of clinical evaluation, imaging studies (such as MRI or CT), and laboratory tests (such as cerebrospinal fluid analysis or fungal cultures). Treatment usually involves long-term antifungal therapy, often with a combination of drugs, and may also include surgical intervention in some cases.
Histoplasmosis is a pulmonary and systemic disease caused by the dimorphic fungus Histoplasma capsulatum. It is typically acquired through the inhalation of microconidia from contaminated soil, particularly in areas associated with bird or bat droppings. The infection can range from asymptomatic to severe, depending on factors like the individual's immune status and the quantity of inhaled spores.
In acute histoplasmosis, symptoms may include fever, cough, fatigue, chest pain, and headache. Chronic or disseminated forms of the disease can affect various organs, such as the liver, spleen, adrenal glands, and central nervous system, leading to more severe complications. Diagnosis often involves serological tests, cultures, or histopathological examination of tissue samples. Treatment depends on the severity and dissemination of the disease, with antifungal medications like itraconazole or amphotericin B being commonly used for moderate to severe cases.
I'm sorry for any confusion, but "Wisconsin" is a U.S. state located in the Midwest and is not a medical term or condition. If you have any medical questions or terms you would like defined, I'd be happy to help with those!
Fungal antigens are substances found on or produced by fungi that can stimulate an immune response in a host organism. They can be proteins, polysaccharides, or other molecules that are recognized as foreign by the host's immune system. Fungal antigens can be used in diagnostic tests to identify fungal infections, and they can also be targets of immune responses during fungal infections. In some cases, fungal antigens may contribute to the pathogenesis of fungal diseases by inducing inflammatory or allergic reactions. Examples of fungal antigens include the cell wall components of Candida albicans and the extracellular polysaccharide galactomannan produced by Aspergillus fumigatus.
Itraconazole is an antifungal medication used to treat various fungal infections, including blastomycosis, histoplasmosis, aspergillosis, and candidiasis. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting the integrity and function of these membranes. Itraconazole is available in oral and intravenous forms for systemic use and as a topical solution or cream for localized fungal infections.
Medical Definition:
Itraconazole (i-tra-KON-a-zole): A synthetic triazole antifungal agent used to treat various fungal infections, such as blastomycosis, histoplasmosis, aspergillosis, and candidiasis. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes, leading to disruption of their integrity and function. Itraconazole is available in oral (capsule and solution) and intravenous forms for systemic use and as a topical solution or cream for localized fungal infections.
Coccidioidomycosis is a fungal infection caused by the inhalation of spores of the Coccidioides species, mainly C. immitis and C. posadasii. These fungi are commonly found in the soil of dry regions such as the southwestern United States, Mexico, and Central and South America.
The infection often begins when a person inhales the microscopic spores, which can lead to respiratory symptoms resembling a common cold or pneumonia. Some people may develop more severe symptoms, especially those with weakened immune systems. The infection can disseminate to other parts of the body, causing skin lesions, bone and joint inflammation, meningitis, or other complications in rare cases.
Diagnosis typically involves a combination of clinical evaluation, imaging studies, and laboratory tests such as fungal cultures, histopathological examination, or serological tests to detect antibodies against Coccidioides antigens. Treatment depends on the severity of the infection and the patient's immune status. Antifungal medications like fluconazole, itraconazole, or amphotericin B are commonly used for treating coccidioidomycosis. Preventive measures include avoiding inhaling dust in endemic areas, especially during excavation or construction activities.
Antifungal agents are a type of medication used to treat and prevent fungal infections. These agents work by targeting and disrupting the growth of fungi, which include yeasts, molds, and other types of fungi that can cause illness in humans.
There are several different classes of antifungal agents, including:
1. Azoles: These agents work by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Examples of azole antifungals include fluconazole, itraconazole, and voriconazole.
2. Echinocandins: These agents target the fungal cell wall, disrupting its synthesis and leading to fungal cell death. Examples of echinocandins include caspofungin, micafungin, and anidulafungin.
3. Polyenes: These agents bind to ergosterol in the fungal cell membrane, creating pores that lead to fungal cell death. Examples of polyene antifungals include amphotericin B and nystatin.
4. Allylamines: These agents inhibit squalene epoxidase, a key enzyme in ergosterol synthesis. Examples of allylamine antifungals include terbinafine and naftifine.
5. Griseofulvin: This agent disrupts fungal cell division by binding to tubulin, a protein involved in fungal cell mitosis.
Antifungal agents can be administered topically, orally, or intravenously, depending on the severity and location of the infection. It is important to use antifungal agents only as directed by a healthcare professional, as misuse or overuse can lead to resistance and make treatment more difficult.
Dermatomycoses are a group of fungal infections that affect the skin, hair, and nails. These infections are caused by various types of fungi, including dermatophytes, yeasts, and molds. Dermatophyte infections, also known as tinea, are the most common type of dermatomycoses and can affect different areas of the body, such as the scalp (tinea capitis), beard (tinea barbae), body (tinea corporis), feet (tinea pedis or athlete's foot), hands (tinea manuum), and nails (tinea unguium or onychomycosis). Yeast infections, such as those caused by Candida albicans, can lead to conditions like candidal intertrigo, vulvovaginitis, and balanitis. Mold infections are less common but can cause skin disorders like scalded skin syndrome and phaeohyphomycosis. Dermatomycoses are typically treated with topical or oral antifungal medications.
Paracoccidioidomycosis is a deep fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis, which is endemic in certain regions of Central and South America. The infection primarily affects the lungs but can disseminate to other organs such as the lymph nodes, mucous membranes, skin, and central nervous system.
The disease typically manifests in two clinical forms: acute/subacute (also known as juvenile) and chronic. The acute form tends to occur in younger individuals and is characterized by widespread dissemination of the fungus throughout the body, often leading to severe symptoms and a higher mortality rate. The chronic form, on the other hand, typically affects adult males and presents with pulmonary lesions and slow-growing granulomatous skin or mucosal ulcers.
Diagnosis of paracoccidioidomycosis is usually made by identifying the characteristic "pilot's wheel" or "Mickey Mouse ear" shaped yeast cells in tissue samples, sputum, or other bodily fluids using direct examination, culture, or histopathological methods. Treatment typically involves antifungal therapy with medications such as trimethoprim-sulfamethoxazole, itraconazole, or amphotericin B, depending on the severity and extent of infection.
Amphotericin B is an antifungal medication used to treat serious and often life-threatening fungal infections. It works by binding to the ergosterol in the fungal cell membrane, creating pores that lead to the loss of essential cell components and ultimately cell death.
The medical definition of Amphotericin B is:
A polyene antifungal agent derived from Streptomyces nodosus, with a broad spectrum of activity against various fungi, including Candida, Aspergillus, Cryptococcus, and Histoplasma capsulatum. Amphotericin B is used to treat systemic fungal infections, such as histoplasmosis, cryptococcosis, candidiasis, and aspergillosis, among others. It may be administered intravenously or topically, depending on the formulation and the site of infection.
Adverse effects associated with Amphotericin B include infusion-related reactions (such as fever, chills, and hypotension), nephrotoxicity, electrolyte imbalances, and anemia. These side effects are often dose-dependent and may be managed through careful monitoring and adjustment of the dosing regimen.
Blastomycosis
Blastomycosis-like pyoderma
Cold abscess
Rhoda Williams Benham
Blastomyces dermatitidis
Richard Summerbell
Periodontal disease
Paracoccidioidomycosis
Albert Balows
Dog health
Blastomyces
Acid-fastness
Itraconazole
Pseudomonal pyoderma
Emergency management
Fluconazole
Lorraine Friedman
Paracoccidioides brasiliensis
Histoplasma capsulatum
Rickettsia
Fever of unknown origin
Fungal meningitis
Fungal infection
Howard Taylor Ricketts
List of dog diseases
Granuloma
Tuberculosis verrucosa cutis
Emmonsiosis
Mouth ulcer
Amphotericin B
Blastomycosis - Wikipedia
Blastomycosis: MedlinePlus Medical Encyclopedia
More Resources | Blastomycosis | Fungal Disease | CDC
Blastomycosis: Practice Essentials, Background, Pathophysiology
BLASTOMYCOSIS: AS SERIOUS AS CANCER - mushing
Etymologia: Blastomycosis - Volume 20, Number 11-November 2014 - Emerging Infectious Diseases journal - CDC
Webinar Thursday, September 21, 2023 - Algorithms for Diagnosing the Endemic Mycoses Blastomycosis, Coccidioidomycosis, and...
Blastomycosis, 2015 - MN Dept. of Health
Blastomycosis in Africa: a new case from Tunisia | European Respiratory Society
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Medical Management of Blastomycosis in a Wild-Born Young Polar Bear (Ursus maritimus) - AAZV 2014 - VIN
Erratum: Blastomycosis-like pyoderma: Novel use of potassium iodide - Indian Journal of Dermatology, Venereology and Leprology
Blastomycosis - Infectious Diseases - MSD Manual Professional Edition
CT findings of intracranial blastomycosis in a dog | Advanced Veterinary Medical Imaging
Blastomycosis| CDC
Blastomycosis Differential Diagnoses
Blastomycosis Spreads - Fungus Therapy - fungustherapy.com
Blastomycosis medication » Which medications for blastomycosis?
Section 19, Chapter 1: Infections of the Spine : Wheeless' Textbook of Orthopaedics
I-Blastomycosis Ezinjeni: Konke Odinga Ukukwazi | 2023
IDEXX case study: Blastomycosis in A Dog - IDEXX Canada
BLASTOMYCOSIS | Harrison's Infectious Diseases, 3e | AccessBiomedical Science | McGraw Hill Medical
38 CFR Appendix C to Part 4 - Appendix C to Part 4-Alphabetical Index of Disabilities | Electronic Code of Federal Regulations ...
Mycology Update 2017 | PPT
Canine Ringworm - A Fungal Infection in dogs
Search WARF - WARF
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USMLE | Multisystem Processes & Disorders
Histoplasmosis10
- The endemic mycoses blastomycosis, coccidioidomycosis (Valley fever), and histoplasmosis are environmental fungal diseases that are frequently misdiagnosed. (cdc.gov)
- Participants will also be introduced to new clinical diagnostic algorithms to address these challenges and improve the timely diagnosis of blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe the epidemiology of blastomycosis, coccidioidomycosis, and histoplasmosis in the United States and the impact of delayed and underdiagnosed cases. (cdc.gov)
- Discuss diagnostic challenges associated with blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Identify populations clinicians should consider testing for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Describe diagnostic tests clinicians should consider initially and after a negative test for blastomycosis, coccidioidomycosis, and histoplasmosis. (cdc.gov)
- Coccidioidomycosis, histoplasmosis, and blastomycosis are underdiagnosed fungal diseases that often mimic bacterial or viral pneumonia and can cause disseminated disease and death. (cdc.gov)
- The national incidence of coccidioidomycosis, histoplasmosis, and blastomycosis is poorly characterized. (cdc.gov)
- however, histoplasmosis is voluntarily reported in 13 states and blastomycosis in five states. (cdc.gov)
- In 2019, a total of 20,061 confirmed coccidioidomycosis, 1,124 confirmed and probable histoplasmosis, and 240 confirmed and probable blastomycosis cases were reported to CDC. (cdc.gov)
Blastomyces14
- In disseminated blastomycosis, the large Blastomyces yeast cells translocate from the lungs and are trapped in capillary beds elsewhere in the body, where they cause lesions. (wikipedia.org)
- Blastomycosis is an infection caused by breathing in the Blastomyces dermatitidis fungus. (medlineplus.gov)
- Blastomycosis is a systemic pyogranulomatous infection usually caused by the inhalation of (spores) conidia of Blastomyces dermatitidis . (medscape.com)
- Blastomycosis, hereafter called blasto, is an infection caused by the fungus Blastomyces dermatitidis (B. dermatitidis). (mushing.com)
- Blastomycosis is caused by the dimorphic fungus Blastomyces dermatitidis , which exists as a mold in the environment and as a pathogenic yeast form in the body. (mn.us)
- Blastomycosis is a pulmonary disease caused by inhaling spores of the dimorphic fungus Blastomyces dermatitidis . (msdmanuals.com)
- Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin. (medscape.com)
- I-Blastomycosis i-systemic fungal infection ebangelwa umzimba I-Blastomyces dermatitidis . (dogsvets.com)
- Nakuba ingekho indlela eqinisekisiwe yokuvimbela i-Blastomycosis, ukunciphisa ukuchayeka kwenja yakho ezindaweni lapho ukhunta lwe-Blastomyces luchuma khona, njengezindawo ezinomhlabathi omanzi nezinto eziphilayo ezibolayo, kungasiza ekunciphiseni ubungozi. (dogsvets.com)
- Interpretation: Pyogranulomatous inflammation with Blastomyces dermatitidis yeast (Blastomycosis). (idexx.com)
- Blastomycosis (Blastomyces dermatitidis) is a systemic fungal infection acquired from soil, most notably in river valleys of the Eastern United States and parts of Canada. (idexx.com)
- Blastomycosis is a systemic pyogranulomatous infection, involving primarily the lungs, that follows inhalation of the conidia of Blastomyces dermatitidis . (mhmedical.com)
- Diana Khuu] Blastomycosis is a fungal disease caused by blastomyces dermatitidis. (cdc.gov)
- Diana Khuu] We decided to do this study because, even though we know quite a bit about the biology and risk factors of infection by Blastomyces dermatitidis , the public health burden of blastomycosis deaths in the United States was unknown. (cdc.gov)
Coccidioidomycosis1
- Arizona and California reported 97% of coccidioidomycosis cases, and Minnesota and Wisconsin reported 75% of blastomycosis cases. (cdc.gov)
North America2
- Most cases of blastomycosis have been reported in North America. (mhmedical.com)
- Acute blastomycosis is typically found only in North America, and the clinical presentation of blastomycosis in nonendemic areas is as a chronic disease. (mhmedical.com)
Management of Blastomycosis1
- Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. (medscape.com)
Diagnosis8
- Because the symptoms are variable and nonspecific, blastomycosis is often not even considered in differential diagnosis until antibacterial treatment has failed, unless there are known risk factors or skin lesions. (wikipedia.org)
- Culture and cytopathology are the gold standard for the diagnosis of blastomycosis. (medscape.com)
- The diagnosis of pulmonary blastomycosis was made at thoracotomy. (ersjournals.com)
- Diagnosis and treatment of systemic blastomycosis in a polar bear ( Ursus maritimus ). (vin.com)
- Blastomycosis should be considered in the differential diagnosis of an atypical pulmonary infection in regions where it is endemic, even in urban areas. (medscape.com)
- Blastomycosis in Africa: clinical features, diagnosis, and treatment. (medscape.com)
- Antigen and antibody testing for the diagnosis of blastomycosis in dogs. (idexx.com)
- In regions where blastomycosis is endemic, the diagnosis should be considered in patients with pulmonary disease. (cdc.gov)
Pulmonary blastomycosis4
- Pulmonary blastomycosis may be asymptomatic or cause an acute, self-limited disease that often goes unrecognized. (msdmanuals.com)
- Pulmonary blastomycosis may resemble lung cancer, and blastomycosis osteomyelitis may resemble bony metastasis. (medscape.com)
- Pulmonary blastomycosis: an appraisal of diagnostic techniques. (medscape.com)
- Pulmonary blastomycosis varies from an asymptomatic infection to acute or chronic pneumonia. (mhmedical.com)
Africa2
- Although blastomycosis is prevalent in the North American continent, it occurs only sporadically in Africa. (ersjournals.com)
- Jerray M, Hayouni A, Benzarti M, Klabi N, Garrouche A. Blastomycosis in Africa: a new case from Tunisia. (medscape.com)
Acute respirat2
- In humans, acute respiratory distress syndrome (ARDS) can be a complication during treatment of blastomycosis, especially in immunocompromised patients. (vin.com)
- Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patient. (vin.com)
Symptoms6
- Lung symptoms are common, because the lungs are infected in 79% of blastomycosis cases. (wikipedia.org)
- less than 50% of healthy people with blastomycosis have symptoms, while immunocompromised patients are especially likely to have the disease spread beyond the lungs to other organs like the skin and bones. (wikipedia.org)
- Blastomycosis in the lungs may present a variety of symptoms, or no symptoms at all. (wikipedia.org)
- Contact your provider if you have symptoms of blastomycosis. (medlineplus.gov)
- In extrapulmonary disseminated blastomycosis, symptoms depend on the organ involved. (msdmanuals.com)
- You should be aware of the symptoms of Blastomycosis. (fungustherapy.com)
Clinical3
- Oral azoles, usually itraconazole or amphotericin B, are first-line treatment for blastomycosis depending on the severity of the disease, its clinical form, and the host's immune status. (medscape.com)
- Clinical and laboratory update on blastomycosis. (cdc.gov)
- Endemic blastomycosis in Mississippi: epidemiological and clinical studies. (medscape.com)
20201
- Available at https://www.who.int/neglected_diseases/events/twelfth_stag/en/ (accessed 7 April 2020). (who.int)
Cutaneous2
- The typical verrucous or ulcerative cutaneous lesions of blastomycosis may mimic skin cancers, such as basal cell carcinoma and squamous cell carcinoma. (medscape.com)
- Primary Cutaneous Blastomycosis. (bvsalud.org)
Nonendemic1
- New York reporting cases of blastomycosis previously thought to be nonendemic. (cdc.gov)
Yeast1
- The fastest way to diagnose blastomycosis is direct identification of the broad based budding yeast forms under microscopy. (medscape.com)
Lungs2
- Blastomycosis, also known as Gilchrist's disease, is a fungal infection, typically of the lungs, which can spread to brain, stomach, intestine and skin, where it appears as crusting purplish warty plaques with a roundish bumpy edge and central depression. (wikipedia.org)
- You may not need to take medicine for a mild blastomycosis infection that stays in the lungs. (medlineplus.gov)
Epidemiology1
- Baumgardner DJ, Buggy BP, Mattson BJ, Burdick JS, Ludwig D. Epidemiology of blastomycosis in a region of high endemicity in north central Wisconsin. (medscape.com)
Mortality5
- Corticosteroids have been shown to reduce mortality in human blastomycosis patients suffering from ARDS. (vin.com)
- Diana Khuu is an author on the article, "Blastomycosis Mortality Rates, United States, 1990 to 2010. (cdc.gov)
- Diana, what is important for people to know about blastomycosis mortality rates and blastomycosis in particular? (cdc.gov)
- The blastomycosis mortality rates were highest in the Midwestern and Southern regions, and we saw that the mortality rate in the Midwestern region has been increasing over the last two decades. (cdc.gov)
- We wanted to look at these risk factors among blastomycosis deaths and see if the risk factors extended to mortality rates. (cdc.gov)
Disease5
- Blastomycosis also affects a broad range of non-human mammals, and dogs in particular are an order of magnitude more likely to contract the disease than humans. (wikipedia.org)
- The signature image of blastomycosis in textbooks is the indolent, verrucous or ulcerated dermal lesion seen in disseminated disease. (wikipedia.org)
- Results of this case report show the importance of considering blastomycosis as a possible etiology in musculoskeletal disease in polar bears, the benefits of anti-inflammatory doses of corticosteroids as an adjunct to treatment, and the application of antigen detection testing to monitor disease status and assist with determining treatment length. (vin.com)
- Canine blastomycosis as a harbinger of human disease. (medscape.com)
- The clearer resulting identification of risk factors from national data may raise provider and community awareness of blastomycosis to make blastomycosis a diagnostic consideration in patients with lung disease. (cdc.gov)
Mimic1
- Blastomycosis has a propensity to mimic carcinoma. (medscape.com)
Dogs2
- CT is therefore recommended as a screening test for intracranial blastomycosis in dogs and also as an imaging modality for follow-up evaluation after treatment. (avmi.net)
- This is particularly true in dogs with systemic or ocular blastomycosis, which appear to be at higher risk of developing CNS involvement. (avmi.net)
ARDS1
- ARDS is an uncommon but dangerous manifestation of blastomycosis. (wikipedia.org)
Azole1
- Treatment of Blastomycosis predominantly relies on azole medications and is often prolonged, lasting months. (idexx.com)
Patients2
- Patients with mild to moderate disseminated blastomycosis without central nervous system involvement should be treated for 6 months. (medscape.com)
- Blastomycosis in patients with the acquired immunodeficiency syndrome. (medscape.com)
California1
- Disseminated blastomycosis in two California sea Lions. (vin.com)
Fatal3
Soil1
- You can get blastomycosis by contact with moist soil, most commonly where there is rotting wood and leaves. (medlineplus.gov)
Nigeria1
- A case of blastomycosis from Zaria, Nigeria. (medscape.com)
Medications1
- Blastomycosis medication » Which medications for blastomycosis? (compharms.com)
Fungus1
- exposed to areas where the fungus could be found, it might be important to ask your doctor to test for blastomycosis. (cdc.gov)
Large2
- Composite photomicrograph of a tissue specimen from a patient with blastomycosis infection shows an abundance of large budding cells that had been configured in chains. (medscape.com)
- A review of blastomycosis in large zoo carnivores. (vin.com)
Case2
Treatment1
- Blastomycosis requires prolonged treatment. (medscape.com)
Found1
- After looking at blastomycosis deaths from 1990 to 2010 death certificate data, we found that blastomycosis deaths were more likely in older people, men, and Native Americans, or blacks. (cdc.gov)
Areas1
- Outdoor activities like hunting or camping in wooded areas increase the risk of developing blastomycosis. (wikipedia.org)
Central1
- Central nervous system blastomycosis may resemble brain neoplasm. (medscape.com)
Death1
- So blastomycosis continues to be a noteworthy cause of preventable death in the United States. (cdc.gov)