Bulbar Palsy, Progressive
A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)
Serotonin Syndrome
An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
Serotonin Uptake Inhibitors
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Monoamine Oxidase Inhibitors
Encyclopedias as Topic
Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Antiganglioside antibody in patients with Guillain-Barre syndrome who show bulbar palsy as an initial symptom. (1/48)
OBJECTIVES: To identify valuable antiganglioside antibodies that support the diagnosis of Guillain-Barre syndrome (GBS) and its variants in patients showing bulbar palsy as an initial symptom. METHODS: Medical records of 602 patients with GBS or its variants were reviewed. Fifteen patients had bulbar palsy as an initial symptom. Serum antibodies against GM1, GM1b, GD1a, GalNAc-GD1a, GT1a, and GQ1b were examined in 13 of them. RESULTS: Serum antiganglioside antibodies were positive in 11 (85%) patients. IgG anti-GT1a (n=8; 62%) and anti-GM1b (n=7; 54%) antibodies were often present, whereas all the patients had low or no anti-GM1 antibody activity. High anti-GD1a and anti-GQ1b IgG antibody titres were also present in some patients, but most had higher IgG antibody titres to GM1b or GT1a. All five patients with high IgG antibody titre to GM1b or GT1a only had had antecedent diarrhoea. Some patients with pharyngeal-cervical-brachial weakness (PCB) had IgG antibody to GT1a which did not cross react with GQ1b. Other patients with PCB had antibody to GT1a which cross reacted with GQ1b or antibody to GM1b, but anti-GM1b and anti-GT1a antibodies were not associated with the presence of bulbar palsy. All the patients who had no IgG antiganglioside antibodies recovered completely. CONCLUSIONS: Measurement of serum IgG anti-GT1a and anti-GM1b antibodies gives helpful support for the diagnosis of GBS and its variants when there is early involvement of the oropharyngeal function independently of other neurological findings which appear as the illness progresses. (+info)Worster-Drought syndrome, a mild tetraplegic perisylvian cerebral palsy. Review of 47 cases. (2/48)
A retrospective case-note analysis was undertaken of 47 children with a congenital upper motor neurone bulbar palsy (excluding pure speech dyspraxia) to clarify the phenotype of Worster-Drought syndrome (WDS) and to record its associated features and complications. The results revealed that the study children had significant bulbar problems (with 80% still needing a modified diet and a similar number using augmentative communication methods at last review). There were also high rates of predictable bulbar complications (86% had dribbling, 60% had glue ear, gastro-oesophageal reflux in 40%, history of poor nutrition in 40% and aspiration in 40%). Most of the children had additional complex impairments (91% had mild pyramidal tetraplegia, 81% learning difficulties, 60% congenital defects, 41% neuropsychiatric problems and 28% epilepsy). Over half of the children had significant medical problems in the first year, but mean age at diagnosis was 6 years. There were no obvious causes in pregnancy or birth. Six children had a family history of WDS and 32% (12/37) had abnormal neuroimaging including five with bilateral perisylvian polymicrogyria. In our experience, WDS is not uncommon, is relatively easily diagnosed and is crucial not to miss as the management of these children's multiple impairments is complex and requires a careful team approach. WDS falls clearly within the cerebral palsies as a syndrome that includes motor impairment arising from static damage to the brain in early life. The common presence of cognitive, behavioural and seizure impairments strongly supports the cerebral cortical (presumably perisylvian) localization. Its core elements are a suprabulbar paresis, a mild spastic tetraplegia and a significant excess of cognitive and behavioural impairments and epilepsy. The complete overlap in phenotype between WDS and the bilateral perisylvian syndrome leads us to propose that they are the same condition. WDS is startlingly absent from epidemiological studies of the cerebral palsies and rarely diagnosed, presumably because of lack of clinical awareness of the condition and lack of major gross motor impairments. (+info)Motor neuron diseases in the university hospital of Fortaleza (Northeastern Brazil): a clinico-demographic analysis of 87 cases. (3/48)
In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS. (+info)Non-invasive screening for surgical intracranial lesions. (4/48)
The value and reliability of the combined results of skull radiographs, electroencephalography, echoencephalography, isotope angiography, and brain scanning in 147 patients suspected of having an intracranial space occupying lesions are analysed. The overall accuracy of the technique was 79%. No false negatives were found. The advantages of adopting the system proposed by the authors in everyday clinical work is discussed. (+info)Rehabilitation for postpolio sequelae. (5/48)
BACKGROUND: Postpolio sequelae (PPS) are new, late manifestations that occur many years after the initial poliomyelitis infection. Recurrence of symptoms and fear of reactivation of the polio virus is particularly distressing to polio survivors. OBJECTIVE: This article outlines the diagnosis, pathophysiology, and management of PPS disabilities using a case vignette. DISCUSSION: Clinical features of PPS include fatigue, joint and muscle pain, new muscular weakness and bulbar symptoms. Diagnosis can be complicated particularly in nonparalytic cases of poliomyelitis. Disabilities in PPS may not be obvious to the observer but significantly affect the quality of life of the PPS patient. Previous rehabilitation intervention focussed on physical effort and determination to overcome disability at all costs. The treatment in PPS is now modified, and aggressive physical measures that may exacerbate muscle weakness are avoided. Most disabilities in PPS can be well managed with rehabilitation interventions that address limitations in patient activities of daily living, mobility and cardiopulmonary fitness. (+info)Subacute bulbar palsy as the initial sign of follicular thyroid cancer. (6/48)
We report a 64-year-old woman with follicular thyroid cancer found by subacute bulbar palsy. Progressive bulbar palsy (PBP) was considered the most likely diagnosis, because no abnormal finding was detected on brain CT and blood test except for the decrease of free T4. An echogram of the thyroid revealed a small nodule which was shown to be class IIb by fine needle biopsy. However, 201Tl scintillation examination showed skull base metastasis. Follicular thyroid cancer sometimes seems to manifest as a distant metastasis with no clinically evident thyroid lesion. This case suggested the importance of a detailed survey for malignancy, when subacute bulbar palsy is seen. (+info)Congenital oculo-bulbar palsy. (7/48)
A girl developed progressive weakness of bulbar and ocular muscles starting before the age of two years. Electromyography revealed a widespread subclinical myopathy. An intercostal muscle biopsy showed complex abnormalities including occasional neurofilamentous accumulations and honeycomb-like membranous material in terminal axons. Endplates were small and some secondary synaptic clefts were abnormally deep. Acetylcholine receptors extended unusually deeply into the clefts of the junctional folds. Muscle fibres showed subsarcolemmal vacuolation at some places. This form of congenital oculo-bulbar palsy does not appear to have been described previously. (+info)The Scottish Motor Neuron Disease Register: a prospective study of adult onset motor neuron disease in Scotland. Methodology, demography and clinical features of incident cases in 1989. (8/48)
The Scottish Motor Neuron Disease Register (SMNDR) is a prospective, collaborative, population based study of motor neuron disease (MND) in Scotland. The register started in January 1989 with the aim of studying the clinical and epidemiological features of MND by prospectively identifying incident patients. It is based on a system of registration by recruitment from multiple sources, followed by the collection of complete clinical data and follow up, mainly through general practitioners. In this report the register's methodology and the demography and incidence data for the first year of study are presented. One hundred and fourteen newly diagnosed patients were identified in 1989 giving a crude incidence for Scotland of 2.24/100,000/year. Standardised incidence ratios showed a non-significant trend towards lower rates in north eastern regions and island areas. (+info)Progressive Bulbar Palsy (PBP) is a form of neurodegenerative disorder, specifically a motor neuron disease, characterized by the deterioration of the bulbar muscles that control swallowing, speaking, chewing, and sometimes breathing, due to the degeneration of lower brainstem nerve cells, often progressing to significant disability and shortened lifespan.
Progressive bulbar palsy (PBP) is a form of motor neuron disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS). It is characterized by the progressive degeneration of the motor neurons in the brainstem, which control vital functions such as swallowing, speaking, chewing, and breathing.
In PBP, these symptoms gradually worsen over time, often resulting in severe disability and ultimately death due to respiratory failure. The progression of the disease can vary from person to person, but it typically advances more slowly than other forms of ALS. There is currently no cure for PBP or any other form of MND, and treatment is focused on managing symptoms and maintaining quality of life.
Serotonin Syndrome is a potentially life-threatening condition characterized by a rapid increase in serotonin levels, leading to a spectrum of symptoms ranging from mild (shivering, diarrhea) to severe (muscle rigidity, fever, seizures, irregular heartbeat), often caused by the interaction of medications or recreational drugs that increase serotonin activity.
Serotonin syndrome is a potentially life-threatening condition that arises from excessive serotonergic activity in the central nervous system (CNS) and peripheral nervous system. It is typically caused by the interaction of medications, illicit substances, or dietary supplements that increase serotonin levels or enhance serotonin receptor sensitivity.
The diagnostic criteria for serotonin syndrome include:
1. Presence of a serotonergic medication or drug known to cause the syndrome
2. Development of neuromuscular abnormalities, such as hyperreflexia, myoclonus, tremor, rigidity, or akathisia
3. Autonomic dysfunction, including diaphoresis, tachycardia, hypertension, dilated pupils, and hyperthermia
4. Mental status changes, such as agitation, confusion, hallucinations, or coma
5. Symptoms that develop rapidly, usually within hours of a change in serotonergic medication or dosage
Serotonin syndrome can range from mild to severe, with the most severe cases potentially leading to respiratory failure, rhabdomyolysis, disseminated intravascular coagulation (DIC), and death. Treatment typically involves discontinuation of the offending agent(s), supportive care, and pharmacologic interventions such as cyproheptadine or cooling measures for hyperthermia.
Methylergonovine is a synthetic ergot alkaloid used primarily for the prevention and treatment of postpartum hemorrhage due to uterine atony, exerting its effect by contracting uterine smooth muscle.
Methylergonovine is a medication that belongs to a class of drugs called ergot alkaloids. It is primarily used to prevent and treat uterine bleeding after childbirth. Medically, it is defined as a semi-synthetic ergopeptide analog with oxytocic properties, which stimulates myometrial contractions and reduces postpartum hemorrhage.
Methylergonovine works by stimulating the smooth muscle of the uterus, causing it to contract. This helps to return the uterus to its pre-pregnancy size and also helps to control bleeding after childbirth. It is important to note that methylergonovine should only be used under the supervision of a healthcare provider, as it can have serious side effects if not used properly.
Serotonin Uptake Inhibitors (SSRIs) are a class of antidepressant medications that work by blocking the reuptake of serotonin into the presynaptic neuron, thereby increasing the availability of serotonin in the synaptic cleft and enhancing its postsynaptic effect.
Serotonin uptake inhibitors (also known as Selective Serotonin Reuptake Inhibitors or SSRIs) are a class of medications primarily used to treat depression and anxiety disorders. They work by increasing the levels of serotonin, a neurotransmitter in the brain that helps regulate mood, appetite, and sleep, among other functions.
SSRIs block the reuptake of serotonin into the presynaptic neuron, allowing more serotonin to be available in the synapse (the space between two neurons) for binding to postsynaptic receptors. This results in increased serotonergic neurotransmission and improved mood regulation.
Examples of SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). These medications are generally well-tolerated, with side effects that may include nausea, headache, insomnia, sexual dysfunction, and increased anxiety or agitation. However, they can have serious interactions with other medications, so it is important to inform your healthcare provider of all medications you are taking before starting an SSRI.
Serotonin is a neurotransmitter synthesized from the essential amino acid tryptophan, primarily found in the enterochromaffin cells of the gastrointestinal tract and in serotonergic neurons of the central nervous system, where it contributes to various functions including mood regulation, appetite control, sleep, memory, and learning.
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter that is found primarily in the gastrointestinal (GI) tract, blood platelets, and the central nervous system (CNS) of humans and other animals. It is produced by the conversion of the amino acid tryptophan to 5-hydroxytryptophan (5-HTP), and then to serotonin.
In the CNS, serotonin plays a role in regulating mood, appetite, sleep, memory, learning, and behavior, among other functions. It also acts as a vasoconstrictor, helping to regulate blood flow and blood pressure. In the GI tract, it is involved in peristalsis, the contraction and relaxation of muscles that moves food through the digestive system.
Serotonin is synthesized and stored in serotonergic neurons, which are nerve cells that use serotonin as their primary neurotransmitter. These neurons are found throughout the brain and spinal cord, and they communicate with other neurons by releasing serotonin into the synapse, the small gap between two neurons.
Abnormal levels of serotonin have been linked to a variety of disorders, including depression, anxiety, schizophrenia, and migraines. Medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), are commonly used to treat these conditions.
Monoamine Oxidase Inhibitors (MAOIs) are a class of drugs that function by inhibiting the activity of monoamine oxidase enzymes, which are responsible for breaking down monoamines such as neurotransmitters, thereby leading to an increase in the levels and duration of action of these neurotransmitters in the brain.
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that work by blocking the action of monoamine oxidase, an enzyme found in the brain and other organs of the body. This enzyme is responsible for breaking down certain neurotransmitters, such as serotonin, dopamine, and norepinephrine, which are chemicals that transmit signals in the brain.
By inhibiting the action of monoamine oxidase, MAOIs increase the levels of these neurotransmitters in the brain, which can help to alleviate symptoms of depression and other mood disorders. However, MAOIs also affect other chemicals in the body, including tyramine, a substance found in some foods and beverages, as well as certain medications. As a result, MAOIs can have serious side effects and interactions with other substances, making them a less commonly prescribed class of antidepressants than other types of drugs.
MAOIs are typically used as a last resort when other treatments for depression have failed, due to their potential for dangerous interactions and side effects. They require careful monitoring and dosage adjustment by a healthcare provider, and patients must follow strict dietary restrictions while taking them.
"Encyclopedias, as a medical topic, refer to comprehensive and organized collections of information on various medical disciplines, theories, practices, diseases, treatments, and related health sciences, serving as extensive reference sources for medical professionals, students, researchers, and general public." (29 words)
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Adrenergic Uptake Inhibitors are a class of medications that block the reuptake of neurotransmitters noradrenaline and adrenaline into the presynaptic neuron, thereby increasing their availability and duration of action in the synaptic cleft, which results in increased nerve impulse transmission.
Adrenergic uptake inhibitors are a class of medications that work by blocking the reuptake of neurotransmitters, such as norepinephrine and dopamine, into the presynaptic neuron. This results in an increase in the amount of neurotransmitter available to bind to postsynaptic receptors, leading to an enhancement of adrenergic transmission.
These medications are used in the treatment of various medical conditions, including depression, attention deficit hyperactivity disorder (ADHD), and narcolepsy. Some examples of adrenergic uptake inhibitors include:
* Tricyclic antidepressants (TCAs): These medications, such as imipramine and amitriptyline, were developed in the 1950s and are used to treat depression, anxiety disorders, and chronic pain.
* Selective serotonin-norepinephrine reuptake inhibitors (SNRIs): These medications, such as venlafaxine and duloxetine, were developed in the 1990s and are used to treat depression, anxiety disorders, and chronic pain.
* Norepinephrine-dopamine reuptake inhibitors (NDRIs): These medications, such as bupropion, are used to treat depression and ADHD.
It's important to note that these medications can have side effects and should be used under the supervision of a healthcare provider.
Progressive bulbar palsy
The term infantile progressive bulbar palsy is used to describe progressive bulbar palsy in children. The ICD-11 lists ... Progressive bulbar palsy symptoms can include progressive difficulty with talking and swallowing. Patients can also exhibit ... Progressive bulbar palsy (PBP) is a medical condition. It belongs to a group of disorders known as motor neuron diseases. PBP ... The patient developed progressive bulbar palsy, became dependent on a respirator, and had two episodes of cardiac arrest. The ...
Infantile progressive bulbar palsy
... is a rare type of progressive bulbar palsy that occurs in children. The disease exists in ... Infantile progressive bulbar palsy. Piña-Garza, J. Eric (2013). Fenichel's Clinical Pediatric Neurology E-Book: A Signs and ...
Bulbar palsy
Progressive bulbar palsy Rea, Paul (2015). "5 - Hindbrain (Rhombencephalon)". Essential Clinical Anatomy of the Nervous System ... In contrast, pseudobulbar palsy is a clinical syndrome similar to bulbar palsy but in which the damage is located in upper ... "Bulbar Palsy". Palsy. Archived from the original on 2011-04-27. (All articles with dead external links, Articles with dead ... Bulbar palsy refers to a range of different signs and symptoms linked to impairment of function of the glossopharyngeal nerve ( ...
Brown-Vialetto-Van Laere syndrome
Families with multiple cases of BVVL and, more generally, multiple cases of infantile progressive bulbar palsy can show ... "Infantile progressive bulbar palsy with deafness". Brain & Development. 24 (7): 732-735. doi:10.1016/S0387-7604(02)00085-2. ... "Bulbar Palsy, Progressive, with Sensorineural Deafness" (PDF). The Catalogue for Transmission Genetics in Arabs Database, ... March 2010). "Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54". ...
Medulla oblongata
Progressive bulbar palsy (PBP) is a disease that attacks the nerves supplying the bulbar muscles. Infantile progressive bulbar ... palsy is progressive bulbar palsy in children. Both lampreys and hagfish possess a fully developed medulla oblongata. Since ... In modern clinical usage, the word bulbar (as in bulbar palsy) is retained for terms that relate to the medulla oblongata, ... The word bulbar can refer to the nerves and tracts connected to the medulla, and also by association to those muscles ...
ALS
... progressive bulbar palsy, pseudobulbar palsy, and monomelic amyotrophy (MMA). As a disease, ALS itself can be classified in a ... Isolated bulbar palsy is characterized by upper or lower motor neuron damage in the bulbar region (in the absence of limb ... and bulbar region. While PMA is associated with longer survival on average than classical ALS, it is still progressive over ... Bulbar-onset ALS begins with weakness in the muscles of speech, chewing, and swallowing and accounts for about 25% of classical ...
Deaths in December 2020
... progressive bulbar palsy. John R. Bentson, 83, American neuroradiologist, complications from COVID-19. Moshe Brawer, 101, ... Mrigendra Nath Maiti, 77, Indian politician, West Bengal MLA (since 2011). Sean Malone, 50, American progressive metal bassist ...
Polish Academy of Literature
... just as one can get accustomed to progressive bulbar palsy. But to start it afresh - that leads to trouble." Wikimedia Commons ...
Spinal and bulbar muscular atrophy
SBMA was first described in Japanese literature in 1897 by Hiroshi Kawahara in a case report detailing progressive bulbar palsy ... The disease causes progressive muscle loss with weakness, fasciculations, and cramps. Weakness of the bulbar muscles follows ... Kennedy, W. R.; Alter, M.; Sung, J. H. (1968). "Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex- ... Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive ...
Fazio-Londe disease
... are the two forms of infantile progressive bulbar palsy, a type of progressive bulbar palsy in children. FLD produces rapidly ... Fazio-Londe disease (FLD), also called progressive bulbar palsy of childhood, is a very rare inherited motor neuron disease of ... It causes progressive bulbar paralysis due to involvement of motor neurons of the cranial nerve nuclei. The most frequent ... The gene encodes the intestinal riboflavin transporter (hRFT2).[citation needed] Symptoms of Fazio-Londe include bulbar palsy, ...
AnnaCarinaPop
... a lot of attention since he had been away from the spotlight for a while after losing his voice due to Progressive bulbar palsy ...
Marc Basnight
Benjamin Brooks of Carolinas Medical Center said Basnight had progressive bulbar palsy and that, while someone could die from ...
PBP
... a stimulant Progressive bulbar palsy, a motor neuron disease Picture by picture, two TV pictures side-by-side, similar to ...
Motor neuron diseases
They include amyotrophic lateral sclerosis (ALS), progressive bulbar palsy (PBP), pseudobulbar palsy, progressive muscular ... "Progressive Muscular Atrophy - an overview , ScienceDirect Topics". sciencedirect.com. Retrieved 24 June 2022. "Motor Neuron ... Bulbar symptoms, including difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and excessive saliva production ... Motor neuron disease describes a collection of clinical disorders, characterized by progressive muscle weakness and the ...
Hypoglossal nerve
Progressive bulbar palsy, a form of motor neuron disease, is associated with combined lesions of the hypoglossal nucleus and ... Bulbar palsy Jugular foramen syndrome Dale Purves (2012). Neuroscience. Sinauer Associates. p. 726. ISBN 978-0-87893-695-3. M. ... Hui, Andrew C. F.; Tsui, Ivan W. C.; Chan, David P. N. (2009-06-01). "Hypoglossal nerve palsy". Hong Kong Medical Journal = ... Keane, James R. (1996-06-01). "Twelfth-Nerve Palsy: Analysis of 100 Cases". Archives of Neurology. 53 (6): 561-566. doi:10.1001 ...
List of MeSH codes (C10)
... bulbar palsy, progressive MeSH C10.574.562.500 - muscular atrophy, spinal MeSH C10.574.562.500.750 - spinal muscular atrophies ... bulbar palsy, progressive MeSH C10.668.460.500 - muscular atrophy, spinal MeSH C10.668.460.500.750 - spinal muscular atrophies ... chronic progressive external MeSH C10.597.622.447.690 - supranuclear palsy, progressive MeSH C10.597.622.669 - paraplegia MeSH ... chronic progressive external MeSH C10.292.562.750.500 - supranuclear palsy, progressive MeSH C10.292.562.775 - ophthalmoplegia ...
List of people with motor neuron disease
This includes amyotrophic lateral sclerosis (ALS), progressive bulbar palsy (PBP), pseudobulbar palsy, progressive muscular ...
Guillaume Duchenne de Boulogne
Progressive bulbar palsy). He was the first clinician to practise muscle biopsy, with an invention he called "l'emporte-pièce ... Duchenne muscular dystrophy Erb-Duchenne palsy Duchenne-Aran disease Essai sur la brûlure (1833) De l'Électrisation localisée ...
Palsy
Bell's palsy, partial facial paralysis Bulbar palsy, impairment of cranial nerves Cerebral palsy, a neural disorder caused by ... also known as wasting palsy Progressive supranuclear palsy, a degenerative disease Squatter's palsy, a common name for ... I. Macpherson JM, Gordon AJ Squatter's palsy British Medical Journal, 1983 Kumaki DJ. The facts of Kathmandu: squatter's palsy ... a disorder affecting the ability to move the eyes Erb's palsy, also known as brachial palsy, involving paralysis of an arm ...
Parkinson's disease
These include progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). PSP predominantly involves rigidity, early ... falls, bulbar symptoms, and vertical gaze restriction; it can be associated with frontotemporal dementia symptoms. CBS involves ... Parkinson-plus syndromes, such as progressive supranuclear palsy and multiple system atrophy, must be considered and ruled out ... progressive supranuclear palsy, and dementia with Lewy bodies. Differential diagnosis can be narrowed down with careful history ...
Pseudobulbar palsy
Motor neuron disease Tidy C (21 October 2021). Knott L (ed.). "Bulbar and Pseudobulbar Palsy. What is Bulbar Palsy?". Patient. ... PMID 7484639.] Graham KC, Spiegel DR (2008). "Pseudobulbar palsy and affect in a case of progressive multifocal ... Corticobulbar tract Bulbar palsy, a similar syndrome caused by the damage of lower motor neurons. ... artery of percheron infarct Progressive supranuclear palsy Amyotrophic lateral sclerosis Parkinson's disease and related ...
Oculopharyngodistal myopathy
... "slowly progressive ptosis and extraocular palsy, and weakness of the masseter, facial, and bulbar muscles, as well as distal ... People with this condition exhibit symptoms susch as progressive muscle weakness affecting the eyes, face, and pharynx which ... Oculopharyngodistal myopathy is a rare genetic disorder characterized by progressive muscle weakness affecting various parts of ...
Chiari malformation
Sleep apnea Sleep disorders Impaired coordination Severe cases may develop all the symptoms and signs of a bulbar palsy ... Syringomyelia is most often chronic progressive degenerative disorder characterized by a fluid-filled cyst located in the ...
Melioidosis
VII nerve palsies and bulbar palsy). Some cases presented with flaccid paralysis alone. In northern Australia, all melioidosis ... Results of a chest X-ray can range from diffuse nodular infiltrates in those with septic shock to progressive consolidation ... Clinical signs include: unilateral upper motor neuron limb weakness, cerebellar signs, and cranial nerve palsies (VI, ...
List of neurological conditions and disorders
Prion diseases Progressive hemifacial atrophy Progressive multifocal leukoencephalopathy Progressive supranuclear palsy ... syndrome Sleep apnea Sleeping sickness Slurred speech Snatiation Sotos syndrome Spasticity Spina bifida Spinal and bulbar ... see Progressive supranuclear palsy Stiff-person syndrome Stroke Sturge-Weber syndrome Stuttering Subacute sclerosing ... body disease Cytomegalovirus Infection Dandy-Walker syndrome Dawson disease De Morsier's syndrome Dejerine-Klumpke palsy ...
List of MeSH codes (C02)
... bulbar MeSH C02.182.600.700.800 - postpoliomyelitis syndrome MeSH C02.256.076.045 - adenovirus infections, human MeSH C02.256. ... bell palsy MeSH C02.256.466.175 - chickenpox MeSH C02.256.466.245 - cytomegalovirus infections MeSH C02.256.466.245.150 - ... progressive interstitial, of sheep MeSH C02.782.815.616.850 - simian acquired immunodeficiency syndrome MeSH C02.782.815.616. ... bulbar MeSH C02.782.687.359.764.650 - postpoliomyelitis syndrome MeSH C02.782.687.359.855 - swine vesicular disease MeSH ...
Neuritis
This neuropathy begins with paralysis and numbness of the soft palate and pharynx as well as bulbar weakness several days to ... It has also been associated with Bell's palsy, and vestibular neuritis. HSV-2 frequently lies within lumbosacral ganglia and is ... resulting in a progressive sensory loss associated with painful paresthesias of the upper limbs, or a mixed sensorimotor ... During acute infection, both direct peripheral nervous involvement, most commonly bilateral facial palsy, and an acute ...
Botulism
Clinicians frequently think of the symptoms of botulism in terms of a classic triad: bulbar palsy and descending paralysis, ... The muscle paralysis is progressive; it usually begins at the hindquarters and gradually moves to the front limbs, neck, and ...
List of diseases (S)
X linked Sixth nerve palsy Sjögren-Larsson syndrome Sjögren's syndrome Skandaitis Skeletal dysplasia brachydactyly Skeletal ... brachymorphia syndrome Sphingolipidosis Spielmeyer-Vogt disease Spina bifida Spina bifida hypospadias Spinal and bulbar ... lower extremity predominance 2 Spinal muscular atrophy with pontocerebellar hypoplasia Spinal muscular atrophy with progressive ... deficiency Summitt syndrome Superior mesenteric artery syndrome Super mesozoic-dysentery complex Supranuclear ocular palsy ...
Augmentative and alternative communication
Cerebral palsy is a term referring to a non-progressive developmental neuromotor disorder with an upper motor neuron lesion ... In the bulbar form, speech is affected before the limbs; here handwriting and typing on keyboard-style devices are frequently ... Depending on the location of the brain lesion, individuals with cerebral palsy can have a wide variety of gross and fine motor ... "Prevalence of Cerebral Palsy". cerebralpalsy.org. Archived from the original on 12 July 2017. Retrieved 26 April 2018. " ...
Progressive bulbar palsy - Wikipedia
The term infantile progressive bulbar palsy is used to describe progressive bulbar palsy in children. The ICD-11 lists ... Progressive bulbar palsy symptoms can include progressive difficulty with talking and swallowing. Patients can also exhibit ... Progressive bulbar palsy (PBP) is a medical condition. It belongs to a group of disorders known as motor neuron diseases. PBP ... The patient developed progressive bulbar palsy, became dependent on a respirator, and had two episodes of cardiac arrest. The ...
Pathology of Motor Neuron Disorders: Definition, Etiology, Epidemiology
... are a clinically and pathologically heterogeneous group of neurologic diseases characterized by progressive degeneration of ... Progressive bulbar palsy. The prevalence of adult-onset progressive bulbar palsy (PBP) is difficult to determine because of the ... Progressive bulbar palsy. Pathologic description of progressive bulbar palsy (PBP) is available in a few reported cases of ... Progressive bulbar palsy. PBP is a progressive degenerative disorder of the motor nuclei in the medulla (specifically involving ...
Article - Billing and Coding: Swallowing Studies for Dysphagia (A56621)
Voice and Swallowing Center | UCSF Health
FAQs | Amyotrophic Lateral Sclerosis (ALS) | CDC
Dr. Stephen Scelsa, MD, Neurology Specialist - New York, NY | Sharecare
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Dementia in Motor Neuron Disease: Overview, Etiology, Epidemiology
Progressive bulbar palsy results in dysphagia, the risk of aspiration pneumonia, and mutism ... MND signs include bulbar weakness with dysarthria and dysphagia, limb weakness, muscle wasting and fasciculations, and, of ... Progressive dementia with symptoms of executive dysfunction, personality change, and motor weakness leads to severe morbidity. ... They are more likely to have a bulbar form of MND, which may help to explain its more aggressive course. ...
walker | ALS Support Community
I was originally diagnosed with progressive bulbar palsy in January of 2018. At that time we were told that there was an ... ability bulbar bulbar onset diagnosed foot life night onset pain pbp peg progression vision vomiting walker work ... als arm breathing bulbar dad diagnosed diagnosis early eating grace lift neurologist progression swallowing symptoms test ...
Online ICD9/ICD9CM codes
ALS and MND: Symptoms, causes, treatment
Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs) - Neurologic Disorders - MSD Manual Professional...
Progressive bulbar palsy and progressive pseudobulbar palsy The bulbar muscles innervated by cranial nerves are predominantly ... Commonly, progressive bulbar palsy spreads, affecting extrabulbar segments; then it is called bulbar-variant ALS. ... In patients with progressive bulbar palsy, surgery to improve swallowing has had limited success. ... In bulbar palsies, only the cranial nerve motor nuclei in the brain stem (bulbar nuclei) are affected. Patients usually present ...
eyes | ALS Support Community
I was diagnosed with progressive Bulbar Palsy I. January 2018. Although I could no longer swallow or speak by April of 2018, a ... bipap bulbar christmas diagnosed eyegaze eyes hours muscle muscles peg swallow tobii worry ... I had lasik in 2001 but it regressed and now I wear progressive lenses again. Im hoping to get either lasik enhancement or... ... Have any of you used progressive lens glasses with a Tobii? How was your experience? Do any of you have advice? ...
Rinsho Shinkeigaku
A case of chronic progressive neuro-Behcets disease with cerebellar ataxia and bulbar palsy preceding mucocutaneo-ocular ... About 3 months after the tick bites, he developed back pain, right leg weakness, right abducens nerve palsy, and left facial ... A 58-year-old female was admitted to our hospital because of recurrent multiple cranial neuropathy (right facial palsy followed ... On admission, he presented with cerebellar ataxia and bulbar symptoms. Brain MRI showed atrophy in the cerebellum and brainstem ...
Pathology of Motor Neuron Disorders: Definition, Epidemiology, Etiology
... are a clinically and pathologically heterogeneous group of neurologic diseases characterized by progressive degeneration of ... Progressive bulbar palsy. The prevalence of adult-onset progressive bulbar palsy (PBP) is difficult to determine because of the ... Progressive bulbar palsy. Pathologic description of progressive bulbar palsy (PBP) is available in a few reported cases of ... Progressive bulbar palsy. PBP is a progressive degenerative disorder of the motor nuclei in the medulla (specifically involving ...
Jane Blaikie 2012 - TURBINE | KAPOHAU
Obituaries - Daily Bulldog - Page 680
The varied motor neuron disease phenotypes | ACNR Journal
... progressive bulbar palsy (PBP, 1-2% of MND cases), an isolated bulbar phenotype with relative preservation of spinal motor ... Bulbar-onset disease may be evident in 20-25% of patients, characterised by progressive dysarthria, dysphagia, hoarseness, ... Czaplinski A, Strobel W, Gobbi C, Steck AJ, Fuhr P, Leppert D. Respiratory failure due to bilateral diaphragm palsy as an early ... Charcot J, Joffroy A. Deux cas datrophie musculaire progressive avec lesion de la substance grise et des faisceaux antero- ...
Potential physiotherapy practice - nmmra.org
... progressive bulbar palsy affects either the upper or lower neurones in the bulbar region, resulting in dysarthria and dysphagia ... leading to bulbar palsy (Stokes, 1998). The clinical presentation acts in accordance with the affected part of the central ... There is a progressive degeneration of nerve cells in the upper and lower motor neurones, leading to muscle weakness and ... Progressive muscular atrophy is caused by degeneration of the lower motor neurones leading to muscle weakness and wasting, ...
Serotonin syndrome - Wikipedia
DeCS - Changed terms
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Specific PHGKB|Rare Diseases PHGKB|PHGKB
DeCS - Changed terms
Amyotrophic lateral sMuscular atrophyParalysisWeaknessBilateralPseudo-bulbarSyndromeSymptomsNeurologicalCerebralMusclesSpinal cordSupranuclearNervesDisorderProstate cancerDementiaGazeDisordersOnsetBrain stemDiagnosisRespiratoryImpairmentPathwayFlaccidPatientsFunctionalDiseases are characterizedSymmetrical
Amyotrophic lateral s7
- The ICD-11 lists progressive bulbar palsy as a variant of amyotrophic lateral sclerosis (ALS). (wikipedia.org)
- In 1869, Charcot studied the involvement of the corticospinal tracts and with Joffroy, who noted the loss of the bulbar motor nuclei, discovered the similarities to amyotrophic lateral sclerosis (ALS). (wikipedia.org)
- This group includes diseases such as amyotrophic lateral sclerosis, progressive bulbar palsy, primary lateral sclerosis, progressive muscular atrophy, spinal muscular atrophy, Kennedy's disease, and post-polio syndrome. (nih.gov)
- Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)
- Motor neurone disease includes a heterogeneous group of disorders with motor neurone involvement, such as amyotrophic lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, and primary lateral sclerosis. (bmj.com)
- Although tongue electromyography was normal, her corticobulbar signs were consistent with amyotrophic lateral sclerosis (ALS), a pattern that, in the absence of -functional impairment outside of speech and swallowing, is appropriately termed progressive bulbar palsy. (bmj.com)
- Aside from Amyotrophic Lateral Sclerosis (ALS), some other subtypes of MND include Progressive Muscular Atrophy (PMA), Progressive Bulbar Palsy (PBP), Primary Lateral Sclerosis (PLS), spinal muscular atrophy, post-polio syndrome, and Kennedy's disease ( 2 ). (veriheal.com)
Muscular atrophy4
- This disorder should not be confused with pseudobulbar palsy or progressive spinal muscular atrophy. (wikipedia.org)
- GBA Duchenne (1806-1875) described a case of the related progressive muscular atrophy (PMA) in 1849, but delayed publishing until 1861. (bmj.com)
- Subtypes of the disease are defined by location of damage, as in progressive bulbar palsy, or preferential involvement of upper or lower motor neuron, as in primary lateral sclerosis or spinal muscular atrophy. (nih.gov)
- Interestingly, although MND includes several other diagnoses like progressive bulbar palsy, primary lateral sclerosis, progressive muscular atrophy, and spinal muscular atrophy, some researchers believe those are also forms of ALS ( 16 ). (veriheal.com)
Paralysis7
- It is a fatal disorder and is characterized by progressive skeletal muscle weakness and wasting or atrophy (ie, amyotrophy), spasticity, and fasciculations as a result of degeneration of the UMNs and LMNs, culminating in respiratory paralysis. (medscape.com)
- Damage to these nerves causes paralysis of the muscles controlled by them, a condition called pontobulbar palsy. (medlineplus.gov)
- Riboflavin transporter deficiency is a progressive neurodegenerative disease characterized by paralysis of the cranial nerves, sensorineural deafness, and signs of damage to other nerves. (nih.gov)
- In this disorder of unknown cause, motor neurons of the brain and spinal cord degenerate, leading to muscle atrophy and progressive paralysis. (nih.gov)
- This causes progressive muscular paralysis. (mhmedical.com)
- Both the upper and lower motor neurons are affected in cases of MND, resulting in rapid loss of muscle control, involuntary muscle spasms , muscle wasting, respiratory weakness, and progressive paralysis. (veriheal.com)
- In the case of damage to the central motor neuron, pseudomembrane paralysis is diagnosed, and when the nerve's motor nucleus or the rest of it is damaged, it is called bulbar syndrome. (medicalwholesome.com)
Weakness10
- Early symptoms of ALS usually include muscle weakness or stiffness in a limb or muscles of the mouth or throat (so-called bulbar muscles). (nih.gov)
- The two patients presented demonstrate two manifestations of 5-FU neurotoxicity, namely a cerebellar syndrome in association with global motor weakness and bulbar palsy, and a bilateral third cranial (oculomotor) nerve palsy. (nih.gov)
- Charcot's major account in 1865, presented to the Société Médicale des Hôpitaux de Paris, was a woman initially diagnosed as an hysteric who had developed progressive weakness, and increased muscle tone, with contractures of all four limbs. (bmj.com)
- 16. [A 74-year-old man with urinary incontinence, right leg weakness and multiple cranial nerve palsies]. (nih.gov)
- It is characterised by progressive muscle weakness and atrophy, with fasciculations associated with hyperreflexia and spasticity. (bmj.com)
- A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. (nih.gov)
- The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. (nih.gov)
- MND is a progressive neurological disorder, resulting in weakness and wasting to muscles involved in movement, breathing, mobility, swallowing and speech. (nhdmag.co.uk)
- He came with a note from his neurologist that said he had 'progressive bulbar palsy', a variant of Lou Gehrig's disease in which the first and dominant symptoms relate to weakness of the muscles of the jaw, face, tongue, pharynx and larynx. (askmelah.com)
- About 70% of ALS patients present with progressive limb weakness, starting close to the body and then out to the extremities ( 2 ). (veriheal.com)
Bilateral2
- The key features are progressive ponto-bulbar palsy and bilateral sensorineural deafness. (nih.gov)
- A 53-year-old man suffering from squamous cell lung cancer presented with bilateral ptosis and bulbar palsy a month after initial treatment with the immune checkpoint inhibitor nivolumab. (elsevierpure.com)
Pseudo-bulbar2
- 17. [A 65-year-old man with rigid-bradykinetic parkinsonism, vertical gaze palsy, difficulty of eye-lid opening, and marked pseudo-bulbar palsy]. (nih.gov)
- Bulbar and pseudo-bulbar syndromes are two syndromes of symptoms associated with damage to the structures of the nervous system. (medicalwholesome.com)
Syndrome6
- Brown-Vialetto-van Laere syndrome an inherited syndrome of progressive bulbar palsy with any of several cranial nerve disorders. (topgrowupclinic.eu)
- 1. What is bulbar and pseudo-bulb syndrome? (medicalwholesome.com)
- 2. What is bulbar syndrome? (medicalwholesome.com)
- Bulbar palsy(Latin syndroma bulbare), also known as bulbar palsy, is a neurological disease syndrome resulting from damage to the nuclei of the cranial nerves, which are located in the medulla medulla (glossopharyngeal, vagus and sublingual nerve). (medicalwholesome.com)
- As a result, the symptom of the bulbar syndrome is slurred nasal speech. (medicalwholesome.com)
- A symptom that distinguishes it from the bulbar syndrome is no muscle atrophy . (medicalwholesome.com)
Symptoms6
- Progressive bulbar palsy symptoms can include progressive difficulty with talking and swallowing. (wikipedia.org)
- Progressive bulbar palsy: a case report diagnosed by lingual symptoms. (wikipedia.org)
- In adults, because most of the cases presenting with these pure bulbar symptoms represent so-called bulbar-onset ALS and eventually develop widespread symptoms typically seen in ALS, some authors consider this disorder to be a subset of ALS. (medscape.com)
- The average duration of life after onset of symptoms of ALS is three years, encompassing a progressive course of increasing disability. (nih.gov)
- Based on disease progression, symptoms and its severity Alzheimer's Disease can be divided into 4 stages which are progressive worsening of symptoms in same continuum. (atomictherapy.org)
- What are the bulbar symptoms? (medicalwholesome.com)
Neurological5
- Motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy motor neurons, the cells that control skeletal muscle activity such as walking, breathing, speaking, and swallowing. (nih.gov)
- Aging-related progressive neurological disorders include frontotemporal dementia, Lou Gehrig s disease, and Alzheimer s disease. (nih.gov)
- To see if the drug [11C]ER176 can show inflammation in the brain in people with certain progressive neurological disorders compared to healthy adults. (nih.gov)
- Progressive neurological deterioration over the course of 5 to 10 years is typical. (mhmedical.com)
- Motor neuron disease (MND) is an umbrella term for a relatively rare group of progressive neurological disorders affecting the brain and nerves. (veriheal.com)
Cerebral2
- Patients with cerebral palsy usually have abnormal neck or truncal tone, asymmetric posture , abnormal strength, gait and coordination. (wikidoc.org)
- Cerebral palsy involves a non-progressive motor dysfunction affecting muscle tone, posture and movement. (wikidoc.org)
Muscles4
- PBP is a disease that attacks the nerves supplying the bulbar muscles. (wikipedia.org)
- PBP is a progressive degenerative disorder of the motor nuclei in the medulla (specifically involving the glossopharyngeal, vagus, and hypoglossal nerves) that produces atrophy and fasciculations of the lingual muscles, dysarthria, and dysphagia. (medscape.com)
- Motor neurone disease (MND), is a progressive neurodegenerative disease that affects the motor neurons responsible for controlling voluntary muscles. (nhdmag.co.uk)
- Progressive Bulbar Palsy (PBP) is when MND begins in the speech and swallowing muscles. (nhdmag.co.uk)
Spinal cord1
- Spinal Muscular Atrophies (SMAs) Spinal muscular atrophies include several types of hereditary disorders characterized by skeletal muscle wasting due to progressive degeneration of anterior horn cells in the spinal cord and. (msdmanuals.com)
Supranuclear1
- progressive supranuclear p. (mhmedical.com)
Nerves1
- Palsy caused by degeneration of the nuclear cells of the lower cranial nerves. (mhmedical.com)
Disorder4
- PLS is a rare, idiopathic neurodegenerative disorder that primarily involves the UMNs, resulting in progressive spinobulbar spasticity. (medscape.com)
- ALS is a progressive fatal neuromuscular disease, the prototype and most common disorder in the class of motor neuron diseases. (nih.gov)
- Alzheimer's Disease (AD) is a chronic progressive neuro-degenerative disorder affecting cognitive functioning and reducing life expectancy. (atomictherapy.org)
- A chronic progressive neurodegenerative disorder in which features of symmetrical Parkinson disease are combined with dementia, falls, impaired gait, and vertical gaze paresis. (mhmedical.com)
Prostate cancer1
- 18. [A 55-year-old man with prostate cancer, papilledema, and multiple cranial nerve palsies]. (nih.gov)
Dementia1
- 19. [A 65-year-old man with Parkinsonism, gaze palsy, and dementia]. (nih.gov)
Gaze2
Disorders2
- HSP, also known as familial spastic paraplegias or Strumpell-Lorrain disease, comprises a clinically and genetically heterogeneous group of hereditary disorders characterized by slowly progressive spastic paraparesis. (medscape.com)
- Motor Neurone Disease (MND) is a group of related disorders characterised by progressive degeneration of upper (corticospinal) and lower (spinal and bulbar) motor neurones. (nhdmag.co.uk)
Onset3
- The prerequisites of diagnosis were progressive and asymmetric lower motor neuron dysfunction, with sensory dysfunction which usually showed in face at the onset. (nih.gov)
- I'm assuming that would be bulbar onset ALS as opposed to Progressive Bulbar Palsy. (mndassociation.org)
- If ALS is confirmed, it does sound like bulbar onset but assume nothing! (mndassociation.org)
Brain stem3
- Progressive bulbar palsy (PBP) , also known as progressive bulbar atrophy, attacks the lower motor neurons connected to the brain stem. (nih.gov)
- In bulbar palsies, only the cranial nerve motor nuclei in the brain stem (bulbar nuclei) are affected. (msdmanuals.com)
- Progressive bulbar palsy is a type of atrophy of the brain stem that affects a person's ability to swallow, speak and chew. (massachusettssocialsecuritydisabilitylawyersblog.com)
Diagnosis1
- After three years of wasted time, I was finally given a diagnosis - and no, not a diagnosis of Lyme disease, rather the opposite in fact - Progressive Bulbar Palsy a rare form of ALS. (laedwardswriter.com)
Respiratory1
- 4. [A 49-year-old man with progressive bulbar palsy and respiratory failure]. (nih.gov)
Impairment1
- The optic foramina are most commonly affected, and the majority of OPTB7 patients presents with progressive visual impairment due to optic nerve compression . (symptoma.com)
Pathway1
- Damage occurs at different heights of the bulbar-bulbar pathway: at the level of the motor cortex, inner capsule, midbrain, or pillar before synaptic switch to the inferior motor neuron. (medicalwholesome.com)
Flaccid1
- The ingestion of the green or ripe fruit of the Karwinskia humboldtiana (buckthorn), a bush known in Mexico as coyotillo or tullidora, causes a flaccid, symmetric, progressive, and ascending palsy of the lower limbs, which, in severe cases, can cause bulbar palsy and death. (unicamp.br)
Patients3
- Progressive bulbar palsy patients that have this mutation are classified with FALS patients, Familial ALS (FALS) accounts for about 5%-10% of all ALS cases and is caused by genetic factors. (wikipedia.org)
- It is not currently known if and how the decreased SOD1 activity contributes to Progressive Bulbar Palsy or FALS, and studies are being done in patients and transgenic mice to help further understand the impact of this gene on the disease. (wikipedia.org)
- Rationale: Patients remain alert and are aware that this is a progressive disease with no cure. (rnpedia.com)
Functional1
- The two relevant issues here are the percentage of functional capacity and the fact that HSP is progressive. (hspersunite.org.au)
Diseases are characterized1
- Motor neuron diseases are characterized by progressive deterioration of the nerve cells that initiate muscle movement. (merckmanuals.com)
Symmetrical1
- In 1871-2, his student Albert Gombault (1844-1904) showed symmetrical sclerosis of the lateral columns and of the bulbar pyramids. (bmj.com)