A genus of the family PICORNAVIRIDAE causing encephalitis and myocarditis in rodents. ENCEPHALOMYOCARDITIS VIRUS is the type species.
Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, isolated from rodents and lagomorphs and occasionally causing febrile illness in man.
The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.
A family of small RNA viruses comprising some important pathogens of humans and animals. Transmission usually occurs mechanically. There are nine genera: APHTHOVIRUS; CARDIOVIRUS; ENTEROVIRUS; ERBOVIRUS; HEPATOVIRUS; KOBUVIRUS; PARECHOVIRUS; RHINOVIRUS; and TESCHOVIRUS.
A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.
A strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.

Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. (1/262)

Theiler's murine encephalomyelitis viruses are picornaviruses that can infect the central nervous system. The DA strain produces an acute polioencephalomyelitis followed by a chronic demyelinating disease in its natural host, the mouse. The ability of DA virus to induce a demyelinating disease renders this virus infection a model for human demyelinating diseases such as multiple sclerosis. Here we describe the generation and characterization of DA virus mutants that contain specific mutations in the viral capsid protein VP1 at sites believed to be important contact regions for the cellular receptor(s). A mutant virus with a threonine-to-aspartate (T81D) substitution in VP1 loop I adjacent to the putative virus receptor binding site exhibited a large-plaque phenotype but had a slower replication cycle in vitro. When this mutant virus was injected into susceptible mice, an altered tropism was seen during the acute stage of the disease and the chronic demyelinating disease was not produced. A virus with a threonine-to-valine substitution (T81V) did not cause any changes in the pattern or extent of disease seen in mice, whereas a virus with a tryptophan substitution at this position (T81W) produced a similar acute disease but was attenuated for the development of the chronic disease. A change in amino acids in a hydrophobic patch located in the wall of the pit, VP1 position 91, to a hydrophilic threonine (V91T) resulted in a profound attenuation of the acute and chronic disease without persistence of virus. This report illustrates the importance of the loop I of VP1 and a site in the wall of the pit in pathogenesis and that amino acid substitutions at these sites result in altered virus-host interactions.  (+info)

Differentiation of M1 myeloid precursor cells into macrophages results in binding and infection by Theiler's murine encephalomyelitis virus and apoptosis. (2/262)

Infection of susceptible mouse strains with BeAn, a less virulent strain of Theiler's murine encephalomyelitis virus (TMEV), results in immune system-mediated demyelinating lesions in the central nervous system (CNS) similar to those in multiple sclerosis. Since macrophages appear to carry the major detectable antigen burden in vivo, and purification of sufficient cell numbers from the CNS for detailed analysis is difficult, macrophage-like cell lines provide an accessible system with which to study virus-macrophage interactions. The myeloid precursor cell line M1 differentiates in response to cytokines and expresses many characteristics of tissue macrophages. Incubation of TMEV with undifferentiated M1 cells produced neither infection nor apoptosis, whereas differentiated M1 (M1-D) cells developed a restricted virus infection and changes indicative of apoptosis. Virus binding and RNA replication as well as cellular production of alpha/beta interferons increased with differentiation. Although the amount of infectious virus was highly restricted, BeAn-infected M1-D cells synthesized and appropriately processed virus capsid proteins at levels comparable to those for permissive BHK-21 cells. Analysis of Bcl-2 protein family expression in undifferentiated and differentiated cells suggests that susceptibility of M1-D cells to apoptosis may be controlled, in part, by expression of the proapoptotic alpha isoform of Bax and Bak. These data suggest that macrophage differentiation plays a role in susceptibility to TMEV infection and apoptosis.  (+info)

Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. (3/262)

OBJECTIVES: This study was designed to examine the effects of pimobendan in a murine model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide (NO) synthesis by inducible NO synthase (iNOS) in the heart. BACKGROUND: Pimobendan has been recently confirmed to improve both acute and chronic heart failure. Since the modulation of myocardial necrosis and contractile dysfunction by various proinflammatory cytokines may be partially mediated by the production of nitric oxide, the effects of pimobendan on the production ofproinflammatory cytokines and NO were investigated in an animal model of viral myocarditis involving heart failure. METHODS: DBA/2 mice were inoculated with the encephalomyocarditis virus. To observe its effect on survival up to 14 days, pimobendan (0.1 mg/kg or 1 mg/kg) or vehicles were given from the day of virus inoculation (day 0) orally once daily. The effects of pimobendan on histological changes, cytokine production, NO production and iNOS gene expression in the heart were studied in mice treated either with pimobendan, 1 mg/kg or with vehicles only, and sacrificed seven days after virus inoculation. RESULTS: The survival of mice improved in a dose-dependent fashion such that a significant difference (p < 0.02) was found between the higher-dose pimobendan group (20 of 30 [66.7%]) and the control group (11 of 30 [36.7%]). Histological scores for cellular infiltration (1.1+/-0.1 vs. 2.0+/-0.0, p < 0.001), intracardiac tumor necrosis factor (TNF)-alpha (18.2+/-1.8 vs. 35.8+/-4.2 pg/mg heart, p < 0.001) and interleukin (IL)-1beta (9.3 +/-1.2 vs. 26.6+/-7.1 pg/mg heart, p < 0.01) were significantly lower in the mice given pimobendan versus those of the control mice. Interleukin-6 levels (7.1+/-0.8 vs. 9.2+/-1.9 pg/mg heart) were also lower in the mice treated with pimobendan. Furthermore, intracardiac NO production was significantly (p < 0.001) less in the pimobendan group (0.165+/-0.004 nmol/mg heart) than in the control group (0.291+/-0.051 nmol/mg heart), and intracardiac iNOS gene expression in the mice given pimobendan was 74% lower than it was in the control animals (p < 0.01). CONCLUSIONS: These findings suggest that the beneficial effects of pimobendan in viral myocarditis are partially mediated by the inhibition of both proinflammatory cytokine production and NO synthesis by iNOS.  (+info)

Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. (4/262)

Serine elastases degrade elastin, stimulate vascular smooth muscle cell migration and proliferation, and are associated with myocardial damage. To evaluate the impact of elastase inhibition on cardiovascular development and disease, transgenic mice were created in which the mouse preproendothelin-1 promoter was used to target elafin overexpression to the cardiovascular system. To distinguish the transgene from endogenous elafin, constructs were made incorporating a FLAG sequence; the COOH-terminus FLAG-tagged elafin construct produced a stable, functionally active gene product and was used to create transgenic mice. Consistent with endothelin expression, abundant elafin mRNA was observed in transgenic F1 embryos (embryonic day 13.5) and in adult transgenic mice heart, trachea, aorta, kidney, lung, and skin, but not in liver, spleen, and intestine. Functional activity of the transgene was confirmed by heightened myocardial elastase inhibitory activity. No tissue abnormalities were detected by light microscopy or elastin content. However, injection of 10 plaque-forming units (PFU) of encephalomyocarditis virus resulted in death within 11 days in 10 out of 12 nontransgenic mice compared with one out of nine transgenic littermates. This reduced mortality was associated with better cardiac function and less myocardial inflammatory damage. Thus, elafin expression may confer a protective advantage in myocarditis and other inflammatory diseases.  (+info)

Encephalomyocarditis (EMC) virus infection in PC12 and C6 cells. (5/262)

PC12 cells derived rom rat pheochromocytoma and C6 cells derived from rat glioma were infected with 0.3 plaque forming units (PFU)/cell of the D variant of encephalomyocarditis virus (EMC-D), after pretreatment with or without nerve growth factor (NGF). The virus titres in medium and cells were investigated at 6, 12, 24, 48 and 72 h post infection (HPI), and histopathology and viral antigens in cells were examined at 24 and 48 HPI, respectively. As a result, neither viral replication nor light and electron microscopic changes were observed in PC12 cell cultures without NGF-pretreatment. On the contrary, in PC12 cell cultures with NGF-pretreatment, the virus titre prominently increased at 12 HPI, and peaked at 48 HPI. In addition, distinct histological and ultrastructural changes with viral antigens in cells were observed. C6 cells showed similar morphology and susceptibility to EMC-D-infection irrespective of NGF-pretreatment. Namely, the virus titres in C6 cell cultures increased slightly and viral antigens were found in a small number of C6 cells, but there were no evident histological and ultrastructural changes. These results suggest that PC12 cells pretreated with NGF and C6 cells are susceptible to EMC-D infection in vitro.  (+info)

Interstitial fibrin-fibronectin deposition with T cell infiltrates precedes fibrosis in murine viral myocarditis. (6/262)

This study was carried out to investigate interstitial fibrin and fibronectin deposition and subsequent myocardial connective tissue abnormalities in BALB/c-nu/+ (euthymic and normal T cell function) and BALB/c-nu/nu (athymic and T cell-deficient) mice. Both types of mice were inoculated with encephalomyocarditis virus and sacrificed periodically. Sections of the hearts were stained with haematoxylin-eosin, trichrome, lymphocyte subsets, silver impregnation, and fibrin or fibronectin. In addition, myocardial collagen concentration was measured. Interstitial fibrin and fibronectin appeared in parallel with inflammatory T lymphocytes and myocardial necrosis in the BALB/c-nu/+ mice. The changes increased until 14 days, subsequently decreasing with time. Interstitial fibrosis and abnormal reticulin fibres were absent until 7 days postinfection, and then increased with time until 60 days. In BALB/c-nu/nu mice, in contrast, although myocardial necrosis and fibrin-fibronectin deposition associated with immature T lymphocytes were evident on days 7 and 14, subsequent myocardial fibrosis and reticulin fibre abnormalities were minimal on days 30 and 60. In BALB/c-nu/+ mice, myocardial collagen concentration increased on day 30, but it did not in BALB/c-nu/nu mice. Thus, interstitial fibrin-fibronectin deposition resulting from virus-induced and T lymphocyte-mediated myocyte necrosis precedes the subsequent development of interstitial fibrosis and abnormal reticulin architectures in this model of murine myocarditis.  (+info)

Theiler's murine encephalomyelitis virus infection induces early expression of c-fos in astrocytes. (7/262)

We have determined whether Theiler's murine encephalomyelitis virus (TMEV), a picornavirus that produces demyelination in genetically susceptible strains of mice, induces c-fos in pure quiescent cultures of mouse brain astrocytes. As observed in Northern blots, the expression of this immediate early gene increases in a dose-dependent manner, with its expression peaking at a multiplicity of infection of 100. The expression of c-fos is transient, peaking after 30 min and disappearing 2 h after infection. The virus is quickly internalized at 37 degrees C upon binding to its specific receptor located at the cell surface and is actively replicated in the cytoplasm of the astrocytes, as demonstrated by FACS flow cytometry. Using the same technique, nuclear translation of c-fos mRNA is also shown. The specificity of viral induction is demonstrated by its neutralization with TMEV-specific antibodies and by the fact that only viral particles and not purified protein components VP1, VP2, and VP3 induced proto-oncogene expression. This rapid induction of c-fos in astrocytes could be the first stage in the infection of these central nervous system cell populations by TMEV. The biological relevance of these findings is assessed by the demonstration of c-fos activation after viral infection in vivo.  (+info)

Potential role of CD4+ T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination. (8/262)

Intracerebral inoculation of Theiler's murine encephalomyelitis virus (TMEV) into susceptible mouse strains results in a chronic, immune-mediated demyelinating disease similar to human multiple sclerosis. Here, we examined the role of astrocytes as an APC population in TMEV-induced demyelination and assessed the potential consequences of T cell activation following Ag presentation. IFN-gamma-pretreated astrocytes were able to process and present all the predominant T cell epitopes of TMEV to virus-specific T cell hybridomas, clones, as well as bulk T cells. Despite low levels of proliferation of T cells due to prostaglandins produced by astrocytes, such Ag presentation by activated astrocytes induced the production of IFN-gamma, a representative proinflammatory cytokine, in TMEV-specific Th cell clones derived from the CNS of virus-infected mice. Furthermore, these Th cell clones mediate lysis of the astrocytes in vitro in a Fas-dependent mechanism. TUNEL staining of CNS tissue demonstrates the presence of apoptotic GFAP+ cells in the white matter of TMEV-infected mice. These results strongly suggest that astrocytes could play an important role in the pathogenesis of TMEV-induced demyelination by activating T cells, subsequently leading to T cell-mediated apoptosis of astrocytes and thereby compromising the blood-brain barrier.  (+info)

Cardiovirus is a genus of positive-stranded RNA viruses that belong to the family Picornaviridae. These viruses are known to cause mild illnesses in humans, such as fever and respiratory symptoms, and can also cause diseases in animals, including myocarditis (inflammation of the heart muscle) and encephalitis (inflammation of the brain).

Cardioviruses are characterized by their small size, non-enveloped structure, and icosahedral symmetry. They infect host cells by binding to specific receptors on the cell surface and releasing their RNA genome into the cytoplasm. The viral RNA then uses the host cell's machinery to translate its genetic information into proteins, which are necessary for the virus to replicate and assemble new virions.

There are two main species of cardioviruses that infect humans: human cardiovirus A (HCVA) and human cardiovirus B (HCVB). HCVA is also known as Saffold virus and is typically associated with mild respiratory illness, while HCVB has been linked to cases of meningitis and encephalitis. However, more research is needed to fully understand the clinical significance of these viruses in humans.

Cardiovirus infections refer to diseases caused by viruses belonging to the Cardiovirus genus of the Picornaviridae family. These viruses are small, single-stranded, positive-sense RNA viruses that infect a wide range of hosts, including humans, animals, and birds.

In humans, the most common cardiovirus is the human enterovirus 71 (HEV71), which primarily causes hand, foot, and mouth disease (HFMD). HFMD is a mild, self-limiting illness characterized by fever, sore throat, and rash on the hands, feet, and mouth. However, in some cases, HEV71 infection can lead to severe neurological complications such as encephalitis, meningitis, and acute flaccid paralysis.

Another important cardiovirus is the Theiler's murine encephalomyelitis virus (TMEV), which primarily infects mice and causes a biphasic disease characterized by an initial phase of flaccid paralysis followed by a second phase of chronic demyelination. TMEV has been used as a model to study the mechanisms of viral-induced demyelination and has provided valuable insights into the pathogenesis of multiple sclerosis.

Cardiovirus infections are typically diagnosed through the detection of viral RNA or antigens in clinical specimens such as stool, throat swabs, or cerebrospinal fluid. Treatment is generally supportive and aimed at managing symptoms, as there are no specific antiviral therapies available for cardiovirus infections. Prevention measures include good hygiene practices, such as handwashing and avoiding close contact with infected individuals.

Mengovirus is a type of picornavirus, specifically a coxsackievirus A21, that is often used as a research reference material due to its ability to cause widespread cytopathic effects in cell cultures. It is named after the location where it was first isolated, the Mengo Hospital in Kampala, Uganda. This virus is not typically associated with human disease, but it has been used in laboratory studies of viral pathogenesis and host immune responses.

Encephalomyocarditis virus (EMCV) is a single-stranded, positive-sense RNA virus belonging to the family Picornaviridae and the genus Cardiovirus. It is a pathogen that can infect a wide range of hosts, including humans, causing encephalomyocarditis, a disease characterized by inflammation of both the brain (encephalitis) and heart (myocarditis).

EMCV infection typically occurs through the ingestion of contaminated food or water. The virus primarily targets organs with high cell turnover rates, such as the brain and heart. Infection can lead to a variety of symptoms, including fever, muscle weakness, neurological disorders, and cardiac dysfunction.

While human cases of EMCV infection are relatively rare, outbreaks have been reported in certain parts of the world, particularly in areas with poor sanitation and hygiene. In addition, EMCV has been identified as a potential bioterrorism agent due to its high virulence and ability to cause severe disease in humans.

Prevention measures include practicing good hygiene and food safety habits, such as washing hands frequently, cooking meat thoroughly, and avoiding contact with potentially contaminated water sources. There is currently no specific treatment for EMCV infection, and management typically involves supportive care to address symptoms and prevent complications.

Picornaviridae is a family of small, single-stranded RNA viruses that are non-enveloped and have an icosahedral symmetry. The name "picornavirus" is derived from "pico," meaning small, and "RNA." These viruses are responsible for a variety of human and animal diseases, including the common cold, poliomyelitis, hepatitis A, hand-foot-and-mouth disease, and myocarditis. The genome of picornaviruses is around 7.5 to 8.5 kilobases in length and encodes a single polyprotein that is processed into structural and nonstructural proteins by viral proteases. Picornaviridae includes several important genera, such as Enterovirus, Rhinovirus, Hepatovirus, Cardiovirus, Aphthovirus, and Erbovirus.

Theilovirus is not typically considered a separate virus in modern virology. Instead, it is now classified as a genotype (genotype 3) of the human parechovirus (HPeV), which belongs to the family Picornaviridae. HPeVs are small, non-enveloped, single-stranded RNA viruses that can cause various clinical manifestations, ranging from mild respiratory or gastrointestinal symptoms to severe neurological diseases in infants and young children.

Historically, Theilovirus was first identified as a separate virus in 1958 by H. Theil and K. Maassab, isolated from the feces of healthy children. It was initially classified as a member of the Enterovirus genus but was later reclassified as a distinct genus, Theilovirus, in 1999. However, subsequent genetic analysis revealed that Theilovirus is closely related to HPeVs, and it is now considered a genotype within the HPeV species.

In summary, Theilovirus is not a separate medical term or virus but rather a historical name for what is now classified as human parechovirus genotype 3 (HPeV3).

I'm sorry for the confusion, but "Maus Elberfeld virus" doesn't seem to be a recognized term in current medical or scientific literature. It is possible that there may be some mistake or misunderstanding in the spelling or the name of the virus you are looking for.

Elberfeld is a city in Germany and "Maus" means mouse in German, so it might be referring to some virus affecting mice in Elberfeld. However, I cannot find any specific information about a virus with this exact name.

If you have more context or details, I'd be happy to help you try to find the information you need!

... a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLOS Pathogens. 5 (5): e1000416. doi: ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...
"Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children". Journal of Virology. 83 (9 ... a Human Theiler's-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLOS Pathogens. 5 (5): e1000416. doi: ... Discovered in 2007, it is the first human virus in the genus Cardiovirus and may provide a link to the development of multiple ... A poly(A) is located on the 3'UTR side, and contained on the 5'UTR side are internal ribosome entry sites (IRES). Cardiovirus ...
The first infection of cardiovirus in humans was identified in 2007 in a stool sample of an infant that was experiencing fever ... Cardiovirus A Cardiovirus B Cardiovirus C Cardiovirus D Cardiovirus E Cardiovirus F Cardiovirus A is composed of only one ... Thus far, Cardiovirus C has only been observed in the brown rat. Cardioviruses are single-stranded RNA, non-enveloped viruses ... Replication of cardioviruses is dependent on a structured RNA element called the Cardiovirus cis-acting replication element ( ...
... is a member of the Picornaviridae family. Infection with the virus causes encephalomyocarditis and reproductive ... Cardioviruses, Swine diseases, All stub articles, Virus stubs, Veterinary medicine stubs). ...
3C and 3D act similarly in rhinovirus as they do in poliovirus because they are both involved in early viral infection of the ... Picornain 3C is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera of picoviruses cause a ... Coxsackievirus is shed through stool and bodily fluids and is prevalent in children but can infection occur in adults. Symptoms ... A small amount of poliovirus infections cause paralysis when the virus infects the nervous system. Poliovirus infects host ...
... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ... respiratory syncytial virus infections MeSH C02.782.580.600.680 - rubulavirus infections MeSH C02.782.580.600.680.500 - mumps ...
The whole of replication occurs within the host-cell cytoplasm and infection can even happen in cells that do not contain a ... Notable examples are genera Enterovirus (including Rhinovirus and Poliovirus), Aphthovirus, Cardiovirus, and Hepatovirus. Look ... As little as 30 minutes after initial infection, though, cell protein synthesis declines to almost zero output - essentially ... In contrast, rhinoviruses are acid-labile (inactivated or destroyed by low pH conditions), so rhinovirus infections are ...
Aditi; Shariff, M. (2019). "Nipah virus infection: A review". Epidemiology and Infection. 147: e95. doi:10.1017/ ... Several genera of picornaviruses have been found in bats, including Kobuvirus, Sapelovirus, Cardiovirus, and Senecavirus. ... In late 2012, a vaccine was released to prevent infection in horses. Vaccine uptake has been low, with an estimated 11-17% of ... Bats' immune systems may have evolved to be more tolerant of stressors such as viral infections compared to other mammals. The ...
There is no specific treatment for a Mengovirus infection; although dipyridamole has been shown to inhibit its replication. The ... belongs to the genus Cardiovirus which is a member of the Picornaviridae. Its genome is a single stranded positive-sense RNA ...
The low serum antibody response of ERBV appears to allow the continual, seasonal re-infection of horses. Horses are also known ... relationship to each other and to aphthoviruses and cardioviruses". J Gen Virol. 77 ( Pt 8) (8): 1719-30. doi:10.1099/0022-1317 ...
Cardiovirus Infections / drug therapy * Cardiovirus Infections / pathology * Cells, Cultured * Chronic Disease * Cytokines / ... We found that VCE-003 ameliorated the symptoms associated to TMEV infection, decreased microglia reactivity and modulated the ...
... a Human Theilers-Like Cardiovirus, is Ubiquitous and Causes Infection Early in Life". PLOS Pathogens. 5 (5): e1000416. doi: ... Infection initiates in astrocytes and microglia, but persists in macrophages. This strain has been used as an acceptable model ... This is the proposed course of disease in TMEV infection in mice. Many bacteria and viruses infect humans without pathology in ... The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. As SJL/J mice are ...
Infection with various picornaviruses may be asymptomatic or may cause clinical syndromes such as aseptic meningitis (the most ... Cardiovirus (type species, encephalomyocarditis virus) is a classic infection in mice, although it has been observed to cause ... Approximately 95% of infections caused by poliovirus and at least 50% of enteroviral infections that are not associated with ... Enteroviral infections occur predominantly in children. In enteroviral infections, antibody prevalence rates of a few serotypes ...
Cardioviruses infection may cause serious complications in biomedical research. To improve the efficiency of routine screening ... Infecções por Cardiovirus/complicações , Infecções por Cardiovirus/patologia , Infecções por Cardiovirus/veterinária , Morte ... Infecções por Cardiovirus/epidemiologia , Infecções por Cardiovirus/transmissão , Infecções por Cardiovirus/virologia , Modelos ... Infecções por Cardiovirus/veterinária , Cardiovirus/classificação , Fezes/virologia , Metagenômica , Ratos/virologia , Animais ...
Involvement of RNAi accessory factors in MDA5/LGP2-mediated cellular responses by Cardiovirus infection(第45回日本免疫学会) ... A possible role of TAR-RNA binding protein phosphorylation in MDA5/LGP2-mediated cellular responses by Cardiovirus infection(第 ... PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2. Biochemical ... The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Biochemical and biophysical ...
Infect, Volume 133, Issue 3, p.547-57 (2005) Keywords: Animals Animals, Domestic Animals, Wild Cardiovirus Infections Disease ... Infections Locomotion Male Population Dynamics prevalence Puumala virus reproduction Rodent Diseases Seasons sex factors Wounds ... Behavioral, physiologic, and habitat influences on the dynamics of Puumala virus infection in bank voles (Clethrionomys ... The prevalence of Chlamydia psittaci infections in Belgian commercial turkey poults7197 https://www.sciensano.be/en/biblio/ ...
Only recently, biochemical and structural studies made it possible to close the gaps in our knowledge on how cardiovirus 2A is ... which is the primary factor for virulence during infections. ... provide a detailed view into the emerging roles of cardiovirus ...
gastrointestinal tract is the primary site of infection. CNS and heart. INTERACTIONS. Cell receptors. : ECMV: Vcam1 Host-virus ... Cardiovirus (taxid:12103). Cardiovirus is a genus of ssRNA+ viruses in the Picornaviridae family that infect vertebrates. In ... gastrointestinal tract is the primary site of infection. CNS and heart. INTERACTIONS. Cell receptors. : ECMV: Vcam1 ASSOCIATED ... Modulation of apoptosis depends on the host cell-type and on the time the infection because of the presence of viral pro- and ...
CONCLUSION: Our results suggest that after TMEV infection, the SVZ may mount an attempt at neuronal repair via emigration, a ... Animals, Biomarkers, Cardiovirus Infections, Cell Lineage, Cell Movement, Cell Proliferation, Disease Models, Animal, ... Hematopoietic cell activation in the subventricular zone after Theilers virus infection. Goings GE., Greisman A., James RE., ... CONCLUSION: Our results suggest that after TMEV infection, the SVZ may mount an attempt at neuronal repair via emigration, a ...
rogrammed -1 ribosomal frameshifting (PRF) in cardioviruses is activated by the 2A protein, a multi-functional virulence factor ... Division of RNA biology of bacterial infections ([HIRI] RABI) * Publications of the group Recoding mechanisms in infections ([ ... Division of RNA biology of bacterial infections ([HIRI] RABI) *Publications of the group Recoding mechanisms in infections ([ ... Publications of the group Recoding mechanisms in infections ([HIRI]REMI). Browse by. TitleAuthorsIssue DateSubmit DateSubjects ...
Cardiovirus Infections. * Diabetes Mellitus, Type 1. * Encephalomyocarditis virus. * Gene Expression. * Glucose Tolerance Test ...
The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has ... A phenomenon in which infection by a first virus results in resistance of cells or tissues to infection by a second, unrelated ... In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T- ... One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle ...
... staph Infection and fungal Infection. Additionally It Assists In Combating Encephalomyocarditis, Cardiovirus And Semliki ... Lung Problems Or Throat infection. It Can Be Very Annoying And Hampers Our Ability To Talk And Socially Interact With People. ...
Only recently, biochemical and structural studies made it possible to close the gaps in our knowledge on how cardiovirus 2A is ... Repurposing thiram and disulfiram as antibacterial agents for multidrug-resistant Staphylococcus aureus infections ... Caliskan and Hill provide a detailed view into the emerging roles of cardiovirus 2A protein, which is the primary factor for ...
Picornaviridae Infections. *Cardiovirus Infections. *Common Cold. *Enterovirus Infections. *Foot-and-Mouth Disease ... Severe Parechovirus 3 Infections in Young Infants-Kansas and Missouri, 2014. J Pediatric Infect Dis Soc. 2018 May 15; 7(2):104- ... "Picornaviridae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Picornaviridae Infections" by people in this website by year, ...
... cardiovirus, parechovirus A, astrovirus VA4, cosavirus-F, and bufavirus-3. Our results showed 71% agreement (k = 0.445, P = ... followed by a mixed infection of human adenovirus and other viruses, which was detected in 20.9% of patients. Also, the newly ... The analysis of viral sequences verified that single infection of human adenovirus was the leading cause of gastroenteritis ... Mixed infection of adenovirus and rotavirus was the predominant (27.4%). A similar percentage of mixed infection of human ...
infection = PICORNAVIRIDAE INFECTIONS. Allowable Qualifiers:. CH chemistry. CL classification. DE drug effects. EN enzymology. ... There are nine genera: APHTHOVIRUS; CARDIOVIRUS; ENTEROVIRUS; ERBOVIRUS; HEPATOVIRUS; KOBUVIRUS; PARECHOVIRUS; RHINOVIRUS; and ... There are nine genera: APHTHOVIRUS; CARDIOVIRUS; ENTEROVIRUS; ERBOVIRUS; HEPATOVIRUS; KOBUVIRUS; PARECHOVIRUS; RHINOVIRUS; and ...
Saffold Cardioviruses in Children with Diarrhea , .... *Necrotizing Pneumonia and ST398 S. aureus , CDC EID ... Viral Hepatitis Co-infection Patterns, Spain , CDC EID. Suggested Citation for this Article. Pérez Cachafeiro S, Caro-Murillo ... we studied co-infections in HIV-seropositive adults. Active hepatitis B infection was more prevalent in persons from Africa, ... To determine if hepatitis C virus seropositivity and active hepatitis B virus infection in HIV-positive patients vary with ...
The clinical outcome of a virus infection may depend upon the conditions under which the infection is acquired: For example, ... A Theilers-like cardiovirus, called Vilyuisk human being encephalomyelitis disease (VHEV), continues to be implicated within ... However, extra-intestinal infection may appear and produce severe fatal encephalomyelitis or a chronic demyelinating ZM-447439 ... Therefore, we figured SAFV-3 is a wide-spread and real human being disease leading to infection ZM-447439 early in existence. ...
HIRI and University of Cambridge shed light onto an essential protein-assisted genetic switch in Cardioviruses / Study ... SARS-CoV-2 Infection: How the virus uses proteins of the cell. 18.01.2021 How do somatic cells and their proteins interact with ... Two new "RNA & Infection" PhD students just started 16.09.2022 Janet Schneider and Chia-Ling Chou join HIRIs graduate program ... At the interface of viral infections and RNA. 20.12.2022 Hailing from a town near Munich, Sebastian has been a PhD student at ...
... with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site ... For the infection experiments, cells were first placed in a 6-well plate (3 × 105 cells/well) for 12 h, then infected with each ... gene and a cardiovirus-derived internal ribosome entry site (IRES) controlling its expression. We recovered two reporter- ... Goertz, G.P.; Abbo, S.R.; Fros, J.J.; Pijlman, G.P. Functional RNA during Zika virus infection. Virus Res. 2018, 254, 41-53. [ ...
One of the helpful features for differentiating EDIM virus infection in neonatal mice from that of other enteric infections is ... Small, nonenveloped, RNA-containing cardiovirus, p79 * 74. Que. How are MEV clinical signs expressed? ... In MHV infection, _______________ formation is a hallmark of infection in many tissues. ... What diagnostic technique is the best method to separate PVM infection from other respiratory infections? ...
Dogs as Sentinels for Human Infection with JEV , C...  Fatal Babesiosis in Man, Finland, 2004 , CDC EID  Human Infection with ... Saffold Cardioviruses in Children, China , CDC EID...  Zoonotic Transmission of Avian Influenza Virus , C...  Influenza A ... Tracing Flu Infections in Mice  Type of Rice Linked to Diabetes Risk  Progress Toward an Artificial Liver Transplant  ... Health Care-Associated Infections: New Study Finds...  Some people do not taste salt like others  Turner Syndrome Society Of ...
ii) Cardio-viruses of rodent e.g. encephalomyocarditis virus, (iii) Rhinovirus which causes respiratory infection like common ... These viruses cause chronic/latent/recurrent infections. Epidemiology of the common herpesvirus infections puzzled clinicians ... Within 12h of infection and before start of DNA replication, there begins early protein synthesis. The synthesis of antigen (i. ... Deletions in E1 minimize the potential of these vector genomes to elicit an infection cycle in human cells. The first clinical ...
A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was ... We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to ... We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to ... A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was ...
There was a lack of information during the early phases of the pandemic concerning the effects of the infection on the host. On ... and a cardiovirus. ... some of the most common viral infections, can also cause ... There are studies which point to links between many viral infections, including measles, rubella, and CMV, and hearing loss. ...
There was a lack of information during the early phases of the pandemic concerning the effects of the infection on the host. On ... and a cardiovirus. ... some of the most common viral infections, can also cause ... There are studies which point to links between many viral infections, including measles, rubella, and CMV, and hearing loss. ...
  • Cardiovirus (type species, encephalomyocarditis virus) is a classic infection in mice, although it has been observed to cause disease in humans. (medscape.com)
  • Encephalomyocarditis virus (Picornaviridae, Cardiovirus A) is the causative agent of the homonymous disease, which may induce myocarditis, encephalitis and reproductive disorders in various mammals, especially in swine. (bvsalud.org)
  • Additionally It Assists In Combating Encephalomyocarditis, Cardiovirus And Semliki Forrest Virus. (bajrangitraderandexporter.com)
  • Picornaviridae Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Picornaviridae Infections" by people in this website by year, and whether "Picornaviridae Infections" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Picornaviridae Infections" by people in Profiles. (childrensmercy.org)
  • We found that VCE-003 ameliorated the symptoms associated to TMEV infection, decreased microglia reactivity and modulated the expression of genes involved in MS pathophysiology. (nih.gov)
  • Theiler's murine encephalomyelitis virus (TMEV) is a single-stranded RNA murine cardiovirus from the family Picornaviridae. (wikipedia.org)
  • This is the proposed course of disease in TMEV infection in mice. (wikipedia.org)
  • The majority of mouse strains are not susceptible to the pathology associated with TMEV infection. (wikipedia.org)
  • Two weeks after TMEV infection, 42% of the untreated TMEV-infected mice were affected by marked inflammation with neuronal loss, whereas 58% exhibited minor inflammation without neuronal loss. (bvsalud.org)
  • Irrespective of the presence of neuronal loss, untreated mice lacked TMEV antigen expression within the hippocampus at 14 days post-infection (dpi). (bvsalud.org)
  • Thus, tamoxifen application during a TMEV infection is associated with transiently increased neuronal loss in the hippocampus, increased reactive astrogliosis and decreased neurogenesis in the DG. (bvsalud.org)
  • CONCLUSION: Our results suggest that after TMEV infection, the SVZ may mount an attempt at neuronal repair via emigration, a process dampened by decreases in neuroblast numbers. (ox.ac.uk)
  • TMEV is an enteric pathogen that primarily causes asymptomatic infections of the alimentary tract. (bibf1120.com)
  • However, extra-intestinal infection may appear and produce severe fatal encephalomyelitis or a chronic demyelinating ZM-447439 disease relevant for multiple sclerosis, with regards to the TMEV stress involved [3]. (bibf1120.com)
  • Nevertheless, this disease, that was isolated upon multiple passages in cell and mice ethnicities, displays close romantic relationship with TMEV and TRV, raising the chance that it represents a contaminating pet cardiovirus [5]. (bibf1120.com)
  • DECIDE brings together research teams from JMU, Würzburg University Hospital, and Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, from Helmholtz Centre for Infection Research in Braunschweig, Technical University of Berlin and University of Münster. (helmholtz-hiri.de)
  • The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. (nupals.ac.jp)
  • Only recently, biochemical and structural studies made it possible to close the gaps in our knowledge on how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. (portlandpress.com)
  • Other picornaviruses, for example the cardioviruses, are believed to initiate replication at the endoplasmic reticulum and subvert PI4KIIIα to generate PI4P. (microbiologyresearch.org)
  • Saffold cardiovirus (SAFV) and characterize the pathogen, for the 5 untranslated region (UTR) ( 3 ). (cdc.gov)
  • After being cloned into the Saffold cardiovirus (SAFV) is a new piconavirus, origi- pGEM-T Easy vector (Promega, Madison, WI, USA), all nally identifi ed from fecal samples of a female infant PCR products were verifi ed by sequencing. (cdc.gov)
  • In 2007, the genomic series was reported of the cardiovirus, provisionally called Saffold disease (SAFV), amplified in cell tradition from the feces of a child showing with fever of unfamiliar source in 1981 [6]. (bibf1120.com)
  • An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. (lookformedical.com)
  • A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was therefore identified substantially expanding the genetic diversity of the RNA viral flora commonly found in children. (ox.ac.uk)
  • APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. (uci.edu)
  • Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways. (uci.edu)
  • Kilbride H, Jackson MA, Selvarangan R. Childhood Outcomes Following Parechovirus Infections in a US Young Infant Cohort. (childrensmercy.org)
  • Lymphocytic choriomeningitis virus (LCMV) carrier mice usually develop as a result of asymptomatic prenatal or neonatal infection, which induces tolerance to the virus. (freezingblue.com)
  • More frequently human infection resembles influenza or is asymptomatic. (freezingblue.com)
  • Therefore, the presence of low copy number of HBoV, detected by molecular method, may indicate prolonged viral shedding or an asymptomatic infection. (datexis.com)
  • The 5 and co-infections, we could not defi nitively say SAFV caused 3 UTR sequences were determined by using the RACE disease. (cdc.gov)
  • SAFV-3 infection occurs early in life ( 7 ), the pathogenicity tion test kit (SERODIA-MYCO II, Fujirebio, Japan). (cdc.gov)
  • Therefore, we figured SAFV-3 is a wide-spread and real human being disease leading to infection ZM-447439 early in existence. (bibf1120.com)
  • Cardiovirus is a genus of ssRNA+ viruses in the Picornaviridae family that infect vertebrates. (expasy.org)
  • The analysis of viral sequences verified that single infection of human adenovirus was the leading cause of gastroenteritis among infants and children, which was detected in 23.2% of the patients, followed by a mixed infection of human adenovirus and other viruses, which was detected in 20.9% of patients. (biomedcentral.com)
  • The clinical outcome of a virus infection may depend upon the conditions under which the infection is acquired: For example, poliomyelitis was seldom observed under conditions of poor sanitation, congenital rubella syndrome is a consequence of postponed childhood infection and some types of cancer are late events in which certain viruses play a crucial role. (bibf1120.com)
  • Among the 17 HBoV-positive patients who were also positive for infection with other viruses, 10 showed PIV infection. (datexis.com)
  • Previous studies have reported that HBoV infection was more prevalent among individuals who had other respiratory viruses [10, 22]. (datexis.com)
  • A unique feature of this approach: The CRC does not focus on a single pathogen, but combines research on several bacteria, viruses and fungi that frequently cause human infections. (helmholtz-hiri.de)
  • Our results showed that, in contrast to the enteroviruses and the cardioviruses, FMDV replication does not require PI4KIII (PI4KIIIα and PI4KIIIβ), and PI4P levels do not increase in FMDV-infected cells and PI4P is not seen at replication organelles. (microbiologyresearch.org)
  • This is, for example, the question of whether an active infection develops after contact with a pathogen or whether a localised infection turns into a systemic disease. (helmholtz-hiri.de)
  • We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to characterize multiple viral species within a previously unreported genus of the Picornaviridae family. (ox.ac.uk)
  • A Theiler's-like cardiovirus, called Vilyuisk human being encephalomyelitis disease (VHEV), continues to be implicated within an outbreak of the neurodegenerative disease among the Yakuts people in Vilyuisk, Siberia, in the 1950s. (bibf1120.com)
  • As for humans, EMCV infection seems to occur by the contact with animals and can cause febrile illnesses in some infected patients. (bvsalud.org)
  • Mice can transmit LCMV to __________, which can remain viremic and viruric for many months even if they contract infection as adults. (freezingblue.com)
  • Pick the terms that correctly complete this sentence: In adult mice with acute LCMV infection, virus multiplies in B cells/T cells and macrophages, whereas B cells/T cells are resistant. (freezingblue.com)
  • Pick the terms that correctly complete this sentence: Regarding LCMV infection in mice, internal viral epitopes induce humoral/cell-mediated responses, but surface epitopes elicit humoral/cell-mediated immunity and neutralizing antibodies. (freezingblue.com)
  • At the cellular level, what causes the lesions of LCMV infection in mice? (freezingblue.com)
  • Pick the term that correctly complete this sentence: Prenatal or neonatal LCMV infection in mice induces immunological tolerance/frank morbidity/death. (freezingblue.com)
  • What is considered a useful husbandry strategy for detecting LCMV infection in mice by seroconversion? (freezingblue.com)
  • Sendai viral replication during natural infection in mice is restricted to which system and which cell types. (freezingblue.com)
  • The interacademy conference, which features top international speakers and is organized with the support of the Alfried Krupp von Bohlen und Halbach Foundation and the Würzburg Helmholtz Institute for RNA-based Infection Research (HIRI), is scheduled to last until tomorrow, September 22. (helmholtz-hiri.de)
  • Würzburg, 25 November 2022-With the participation of the Helmholtz Institute for RNA-based Infection Research (HIRI), a new collaborative research center is being launched in Würzburg. (helmholtz-hiri.de)
  • In recent years, this profile establishment of HIRI and the Max Planck Research Groups for Systems Immunology on the Würzburg Medical Campus has further strengthened the infection research hub in Würzburg. (helmholtz-hiri.de)
  • Several studies have addressed HBV and HCV prevalence in migrants and ethnic minorities (9,10), but few studied viral hepatitis co-infections in HIV-infected persons according to the patients' geographic origins (11,12). (blogspot.com)
  • The high association of HBoV with PIV seems to be attributed to the high prevalence of PIV infection in 2006 (22.8% in May). (datexis.com)
  • Genes for tRNA recycling are upregulated in response to infections with Theiler's mouse encephalitis virus. (nupals.ac.jp)
  • Hematopoietic cell activation in the subventricular zone after Theiler's virus infection. (ox.ac.uk)
  • Within 12h of infection and before start of DNA replication, there begins early protein synthesis. (biologydiscussion.com)
  • Finally, the serosurvey proved that spread of EMCV is greater than the diffusion of fatal infections would suggest, due to subclinical circulation of EMCV. (bvsalud.org)
  • K. Shen) tients exhibited symptoms of respiratory tract infection, DOI: 10.3201/eid1607.091682 such as coughing, gasping, sneezing, or fever. (cdc.gov)
  • To investigate the epidemiological association of respiratory infection with viral load, HBoV-positive patients were categorized into low- and high-viral-load groups by using 1.0×106 copies/mL as a threshold value. (datexis.com)
  • These results suggest that single HBoV infection in the high-viral-load group may play an active role in respiratory infection. (datexis.com)
  • These findings are consistent with a Norwegian study that reported detection of HBoV alone and a high-viral-load were associated with respiratory tract infection. (datexis.com)
  • These findings also support the idea that a high-viral-load may be associated with a respiratory infection. (datexis.com)
  • Würzburg, September 21, 2023-On the occasion of the opening of the interacademy conference "MICROBIOLOGY 2023: from single cell to microbiome & host" , Jörg Hacker was welcomed as the guest of honor at the Institute for Molecular Infection Biology (IMIB) of the University of Würzburg (JMU) yesterday afternoon. (helmholtz-hiri.de)
  • Lesions of LCMV infection appear to develop from direct T cell-mediated damage to virus-infected cells and may involve humoral factors released from immune effector T cells. (freezingblue.com)
  • All principle investigators are leaders in infection biology and immunology. (helmholtz-hiri.de)
  • PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2. (nupals.ac.jp)
  • Infection initiates in astrocytes and microglia, but persists in macrophages. (wikipedia.org)
  • citation needed] One hypothesis for the initiation is that an infection stimulates the innate immune system, specifically perivascular microglia. (wikipedia.org)
  • The relevant question of whether authentic human cardioviruses exist has remained unclear for a long period. (bibf1120.com)
  • Lately, however, strong proof has been acquired for the lifestyle of human being cardioviruses. (bibf1120.com)
  • Human Brucella canis Infections Diagnosed by Blood. (blogspot.com)
  • It investigates critical decision processes that determine the outcome of human infection. (helmholtz-hiri.de)
  • Hacker, a bacteriologist, is considered a pioneer of molecular infection research and is also a co-founder of the interdisciplinary and cross-faculty Research Center for Infectious Diseases (ZINF) at JMU. (helmholtz-hiri.de)
  • To determine if hepatitis C virus seropositivity and active hepatitis B virus infection in HIV-positive patients vary with patients' geographic origins, we studied co-infections in HIV-seropositive adults. (blogspot.com)
  • Anti-Allergic, Antiviral And Antibacterial Properties-Harshingar Oil Can Be Used To Fight Bacteria Such As E.Coli, staph Infection and fungal Infection. (bajrangitraderandexporter.com)
  • Introduction Recent advancements in molecular recognition strategies (viral oligonucleotide microarrays and viral metagenomics techniques) have resulted in the identification of several new infections which are recognized not merely in symptomatic, but similarly in individuals without any clinical manifestation. (bibf1120.com)
  • So far hardly investigated on a broad scale, but of great importance here are certain key decisions that determine the clinical course of an infection. (helmholtz-hiri.de)
  • Despite the disease occurred endemically in pig farms since 1997, the recent increase of death experimented in Northern Italy prompted to furtherly investigate the evolution of the virus and the actual spread of the infection. (bvsalud.org)
  • Severe Parechovirus 3 Infections in Young Infants-Kansas and Missouri, 2014. (childrensmercy.org)
  • The question we addressed in our study was whether HCV seropositivity and active HBV infection in HIV-positive patients vary with the patients' geographic origins. (blogspot.com)
  • In this issue of Bioscience Reports (volume 42, issue 1), Caliskan and Hill provide a detailed view into the emerging roles of cardiovirus 2A protein, which is the primary factor for virulence during infections. (portlandpress.com)
  • gastrointestinal tract is the primary site of infection. (expasy.org)
  • First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
  • ThV is the only cardiovirus to produce two additional proteins from an ORF overlapping the L protein, in another frame. (expasy.org)
  • Pérez Cachafeiro S, Caro-Murillo AM, Berenguer J, Segura F, Gutiérrez F, Vidal F. Association of patients' geographic origins with viral hepatitis co-infection patterns, Spain. (blogspot.com)
  • The lower detection rate and viral load of HBoV in older patients may be attributed to immunity acquired from an infection at a younger age. (datexis.com)
  • suggested that HBoV infection might develop only once because of the subsequent development of life-long immunity conferred by neutralizing antibodies produced in response to the infection. (datexis.com)