Protective activity of the stem bark aqueous extract of Musanga cecropioides in carbon tetrachloride- and acetaminophen-induced acute hepatotoxicity in rats. (1/1)
The hepatoprotective activities and the mechanisms of actions of Musanga cecropioides stem bark aqueous extract (MCW) were investigated on acute hepatocellular injuries induced by intraperitoneal (IP) carbon tetrachloride (CCl(4)) (20% CCl(4)/olive oil, 1.5 mL/kg) and 800 mg/kg/IP of acetaminophen (APAP) in normal saline, in male Wistar rats. Among the Yorubas (South-West Nigeria), cold decoction of MCW is used as a natural antidote for oral gastric poisonings, infective hepatitis and other liver diseases. Its hepatoprotective activities were monitored by assaying for the serum aminotransferases, ornithine carbamoyl transferase and the toxicant-induced histopathological lesions in rat livers 24 hours post-induction. These enzymes are markers of acute hepatic injuries and their elevations are indications of acute liver injuries. Pretreatment of rats with graded doses (125 - 500 mg/kg) of MCW significantly attenuated the acute elevation of the liver enzymes and the hepatotoxin-induced histopathological lesions in the rat livers. The presence of two active natural antioxidants (flavonoids and alkaloids) in high concentrations in MCW may account for the hepatoprotective activities observed in this study. These results, thus, support the folkloric use of MCW for treatment of hepatic injuries resulting from acute gastric poisonings, infective hepatitis or other liver diseases. (+info)Cecropiaceae is a family of flowering plants that includes trees and shrubs found primarily in the tropical regions of the Americas. It was previously classified as a separate family, but recent phylogenetic studies have placed it within the larger family Urticaceae (the nettle family).
The Cecropia genus is the most well-known and largest genus within this group, with over 60 species of trees that can grow up to 40 meters tall. These trees are characterized by their lightweight wood, large leaves, and hollow stems that often contain colonies of ants. The ants provide protection for the tree from herbivores, while the tree provides shelter and food for the ants in return.
Cecropiaceae plants have simple, alternate leaves with stipules at the base of the petiole. They produce small flowers that are arranged in clusters or spikes, and their fruits are typically small and dry. Some species of Cecropia are used in traditional medicine for various purposes, such as treating skin conditions, diarrhea, and fever. However, more research is needed to confirm the safety and efficacy of these uses.
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Cecropia2
- Cecropia obtusa Trécul (Cecropiaceae), a pioneer species associated with the initial phases of vegetation sequences of tropical South American forests. (botany.org)
- It nests in a number of plants, including a 1-meter tall Cordia nodosa [Boraginaceae], in C. hispidissima (Wheeler and Bequaert, 1929), in Cecropia membranacea [Cecropiaceae], and C. polystachya . (antwiki.org)
Urticaceae1
- Classification systems developed prior to the 1990s, such as those of Cronquist (1981) and Dahlgren (1989), typically recognized the order Urticales , which included the families Cannabaceae, Cecropiaceae, Celtidaceae, Moraceae, Ulmaceae and Urticaceae, as then circumscribed. (cannaqa.wiki)
Coussapoa1
- 1990. Cecropiaceae: Coussapoa and Pourouma, with an introduction to the family. (arvoresdobiomacerrado.com.br)