Centella
Pentacyclic Triterpenes
Triterpenes
Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. (1/25)
Ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, were isolated from the aerial parts of Centella asiatica (L.) Urban cultivated in Sri Lanka together with madecassoside, asiaticoside, asiaticoside B, and sceffoleoside A. The chemical structures of centellasaponins B, C, and D were determined on the basis of chemical and physicochemical evidence to be madecassic acid 28-O-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside, madasiatic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyra noside, and 3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyra noside, respectively. (+info)Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. (2/25)
The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated. (+info)Hepatotoxicity associated with the ingestion of Centella asiatica. (3/25)
BACKGROUND: Hepatotoxicity due to herbal remedies is being increasingly recognized. Centella asiatica (Centella asiatica Linn Urban) is commercialized for multiple conditions. Its active principles are pentacyclic triterpenic saponosides (asiaticoside, madecassoside). CLINICAL CASE STUDIES: We present three women (61, 52 and 49 years old) who developed jaundice after taking Centella asiatica for 30, 20 and 60 days. Respective laboratory tests: ALT: 1193, 1694 and 324 U/L; ALP: 503, 472 and 484 U/L; bilirubin: 4.23, 19.89 and 3.9 mg/dl. The first patient also had ASMA 1/160 and AMA 1/320. Respective pathological diagnoses: granulomatous hepatitis with marked necrosis and apoptosis; chronic hepatitis with cirrhotic transformation and intense necroinflammatory activity, and granulomatous hepatitis. All patients improved with Centella asiatica discontinuation, and ursodeoxycholic acid 10 mg/kg/day. The first patient took Centella asiatica again, with recurrence of the damage. The second one had taken this herb a year before. CONCLUSIONS: Many plants synthesize hepatotoxic compounds. Germander, Skullcap and Glycyrrhizin contain di- or triterpenic active principles, which can produce hepatic injury by promoting apoptosis and altering cell membranes. We hypothesize that these mechanisms may have resulted in injuries associated with Centella asiatica. The presence of autoantibodies and granulomas also favors an immune-mediated mechanism. Ursodeoxycholic acid has anti-apoptotic properties, but we cannot rule out that Centella asiatica discontinuation alone may have resulted in patient improvement. (+info)Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban. (4/25)
A cDNA encoding farnesyl diphosphate synthase (FPS; EC2.5.1.1/EC2.5.1.10) was isolated from Centella asiacita (L.) Urban, using degenerate primers based on two highly conserved domains. A full-length cDNA clone was subsequently isolated by rapid amplification of cDNA ends (RACE) PCR. The sequence of the CaFPS (C. asiatica farnesyl diphosphate synthase) cDNA contains an open reading frame of 1029 nucleotides encoding 343 amino acids with a molecular mass of 39.6 kDa. The deduced CaFPS amino acid sequence exhibits 84, 79, and 72%, identity to the FPSs of Artemisia annua, Arabidopsis thaliana, and Oryza sativa, respectively. Southern blot analysis suggested that the C. asiatica genome contains only one FPS gene. An artificially expressed soluble form of the CaFPS was identified by SDS-PAGE. It had high specific activity and produced farnesyl diphosphate as the major isoprenoid. (+info)Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts. (5/25)
Centella asiatica (CA) and Rhinacanthus nasutus (RN )have been used for treatment of various illnesses, but the mechanisms of action remain largely unknown. This study focused on the influence of CA and RN extracts on cell-mediated and humoral immune responses. In human peripheral blood mononuclear cells (PBMCs), CA (water extract) and RN (water and ethanol extracts) significantly increased proliferation and the production of IL-2 and TNF-alpha. In contrast, an ethanol extract of CA inhibited human PBMC mitogenesis and the production of IL-2 and TNF-alpha. BALB/c mice treated with CA extracts (100 mg/kg bw) showed higher responses to both primary and secondary antibodies against BSA when compared with non-treated group. Only the secondary antibody response was increased in RN extract-treated mice. The present study revealed immunomodulating activity of CA and RN extracts with regard to both non-specific cellular and humoral immune responses. The data available to date suggest that they may have chemopreventive or anticancer potential. (+info)In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. (6/25)
Medicinal plants have many traditional claims including the treatment of ailments of infectious origin. In the evaluation of traditional claims, scientific research is important. The objective of the study was to determine the presence of antibacterial activity in the crude extracts of some of the commonly used medicinal plants in Malaysia, Andrographis paniculata, Vitex negundo, Morinda citrifolia, Piper sarmentosum, and Centella asiatica. In this preliminary investigation, the leaves were used and the crude extracts were subjected to screening against five strains of bacteria species, Methicillin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli, using standard protocol of Disc Diffusion Method (DDM). The antibacterial activities were assessed by the presence or absence of inhibition zones and MIC values. M. citrifolia, P. sarmentosum and C. asiatica methanol extract and A. paniculata (water extract) have potential antibacterial activities to both gram positive S. aureus and Methicillin Resistant S. aureus (MRSA). None of the five plant extracts tested showed antibacterial activities to gram negative E. coli and K. pneumoniae, except for A. paniculata and P. sarmentosum which showed activity towards P. aeruginosa. A. paniculata being the most potent at MIC of 2 g/disc. This finding forms a basis for further studies on screening of local medicinal plant extracts for antibacteria properties. (+info)The anti-thrombotic active constituents from Centella asiatica. (7/25)
The in vitro effects of a methanol extract from the aerial parts of Centella asiatica on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. 3,5-Di-O-caffeoyl quinic acid, 1,5-di-O-caffeoyl quinic acid, 3,4-di-O-caffeoyl quinic acid, 4,5-di-O-caffeoyl quinic acid, and chlorogenic acid, together with asiaticoside, kaempferol, quercetine, kaempferol-3-O-beta-D-glucoside and quercetin-3-O-beta-D-glucoside were all isolated from the methanol extract. Amongst these, only 3,5-di-O-caffeoylquinic acid showed significant inhibition of shear-induced platelet activation and dynamic coagulation. The reactive curve of the inhibitory effect on the platelet reaction and the dynamic coagulation showed a bell-shape. (+info)Dechlorophyllation by electrocoagulation. (8/25)
Electrocoagulation was used for dechlorophyllation of alcoholic extracts from five plants. The results showed that for every plant extract studied, electrocoagulation was more efficient than the classical solvent extraction method in removing plant pigments, while not affecting the important secondary metabolites in those extracts. (+info)"Centella" is the common name for a plant species known scientifically as *Centella asiatica*, also referred to as gotu kola. It is a herb that has been used in traditional medicine in various cultures, including Ayurvedic and Chinese medicine, for its potential health benefits. The active compounds in centella include saponins called asiaticoside, madecassoside, and madasiatic acid, which are believed to have anti-inflammatory, antioxidant, and wound-healing properties.
Centella has been studied for its potential effects on various conditions, such as anxiety, cognitive function, and skin health. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines. As with any supplement or medication, it's important to consult with a healthcare provider before using centella to ensure that it's appropriate for your individual health needs and to avoid potential interactions with other medications.
Pentacyclic triterpenes are a type of natural compounds that are characterized by their structure, which consists of five cyclic rings made up of 30 carbon atoms. They are formed from squalene through a series of enzymatic reactions and can be found in various plants, as well as some animals and marine organisms.
Pentacyclic triterpenes have been studied for their potential medicinal properties, including anti-inflammatory, antiviral, and antitumor activities. Some examples of pentacyclic triterpenes include oleanolic acid, ursolic acid, and betulinic acid, which are found in a variety of fruits, vegetables, and herbs.
It's worth noting that while there is a growing body of research on the potential health benefits of pentacyclic triterpenes, more studies are needed to fully understand their mechanisms of action and therapeutic potential.
Triterpenes are a type of natural compound that are composed of six isoprene units and have the molecular formula C30H48. They are synthesized through the mevalonate pathway in plants, fungi, and some insects, and can be found in a wide variety of natural sources, including fruits, vegetables, and medicinal plants.
Triterpenes have diverse structures and biological activities, including anti-inflammatory, antiviral, and cytotoxic effects. Some triterpenes are also used in traditional medicine, such as glycyrrhizin from licorice root and betulinic acid from the bark of birch trees.
Triterpenes can be further classified into various subgroups based on their carbon skeletons, including squalene, lanostane, dammarane, and ursane derivatives. Some triterpenes are also modified through various biochemical reactions to form saponins, steroids, and other compounds with important biological activities.
Batch cell culture techniques refer to a method of growing cells in which all the necessary nutrients are added to the culture medium at the beginning of the growth period. The cells are allowed to grow and multiply until they exhaust the available nutrients, after which the culture is discarded. This technique is relatively simple and inexpensive but lacks the ability to continuously produce cells over an extended period.
In batch cell culture, cells are grown in a closed system with a fixed volume of medium, and no additional nutrients or fresh medium are added during the growth phase. The cells consume the available nutrients as they grow, leading to a decrease in pH, accumulation of waste products, and depletion of essential factors required for cell growth. As a result, the cells eventually stop growing and enter a stationary phase, after which they begin to die due to lack of nutrients and buildup of toxic metabolites.
Batch cell culture techniques are commonly used in research settings where large quantities of cells are needed for experiments or analysis. However, this method is not suitable for the production of therapeutic proteins or other biologics that require continuous cell growth and protein production over an extended period. For these applications, more complex culture methods such as fed-batch or perfusion culture techniques are used.
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Centella - Wikipedia
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Extract17
- Centella Asiatica Leaf Extract is an extract of the leaves of Centella asiatica. (ewg.org)
- Whether you're looking for Centella Asiatica, Centella Asiatica Dry Extract, Gotukola (Centella Asiatica) etc, you can explore and find the best products from Tradeindia. (tradeindia.com)
- Npure Centella Asiatica Night Cream memiliki formula terbaik yang mengkombinasikan bahan aktif esensial Granactive Acne Peptide, Centella Asiatica Extract, 7 Anti-Acne Plant Extracts, dan Salicylic Acid untuk membantu mengatasi dan merawat kulit yang berjerawat. (tokopedia.com)
- Het centella extract zal de geïrriteerde huid kalmeren waardoor ook roodheden zichtbaar zullen verminderen! (boozyshop.nl)
- A study on the effect of Centella asiatica extract on learning and memory in healthy volunteer. (supaveda.com)
- Efficacy of Standardized extract of Centella asiatica (ECa 233) on cognitive function and mood in healthy elderly subjects: a randomized, double-blind, placebo-controlled study. (supaveda.com)
- It is formulated with 50.79% Centella Asiatica Leaf Water, medical grade Centella Asiatica Extract, Zinc PCA and 7% Zinc Oxide, the cream soothes troubled skin and calms redness and inflammation. (beauty-rx.in)
- Free from essential oils, it's infused with Panthenol and 10% Centella Asiatica extract to provide hydration while soothing and calming skin from external aggressors. (theskincarelibrary.com)
- Centella Unscented Toner (30 ml) with 10% Centella Asiatica extract and Sodium Hylauronate for an intense moisture supply. (niasha.ch)
- Centella Unscented Serum (15 ml) with 49% Centella Asiatica extract, Niacinamide, 4 different Peptides, Panthenol, Ceramide and many other great ingredients that work to brighten, firm and protect your skin. (niasha.ch)
- Centella Unscented Recovery Cream (12 ml) with 50% Centella Asiatica extract to reduce inflammation and irritation. (niasha.ch)
- Centella Asiatica Extract : Soothes and replenishes skin hydration level. (moonskyn.com)
- This soothing sheet mask is formulated with 95% centella asiatica extract that is effective in delivering soothing and calming effect to irritated skin. (coreelle.com)
- Centella Asiatica Extract soothes irritated skin and creates smooth, moisturized skin. (coreelle.com)
- Centella Asiatica Extract strengthens the skin's natural barrier to keep skin healthy. (coreelle.com)
- Winter skin essential which contains highly concentrated Centella asiatica extract. (themedicube.com.sg)
- The added Centella Asiatica Extract ensures that this cleansing oil has an extra moisturizing effect by stimulating the production of hyaluronic acid. (nastelle.com)
Dried Centella Asiatica1
- The raw material is dried Centella asiatica (CA) herb. (nih.gov)
COSRX Centella Blemish Cream2
- The COSRX Centella Blemish Cream is a fast-acting spot treatment cream that improves the appearance of acne and blemishes and relieves stressed skin. (beauty-rx.in)
- Make sure to moisturise your face before applying COSRX Centella Blemish Cream. (beauty-rx.in)
Gotu5
- Brahmi/gotu kola (Centella asiatica) is a vibrant green water-loving herb. (banyanbotanicals.com)
- Introducing our premium grade Gotu Kola, scientifically known as Centella Asiatica. (glenbrookfarm.com)
- Gotu Kola (Centella asiatica) is an herb traditionally used in Ayurvedic medicine for its various health benefits. (supaveda.com)
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. (supaveda.com)
- The common name Brahmi can also refer to a completely different plant gotu kola (Centella asiatica) that has similar medicinal properties to bacopa. (msdmanuals.com)
Cream3
- Tonton video ulasan Npure Centella Asiatica Night Cream, yuk! (tokopedia.com)
- De iUnik Centella Calming AC Spot Cream is een crème behandeling die de strijd tegen puistjes aangaat! (boozyshop.nl)
- Centella Unscented Recovery Cream: Take a small amount and massage onto face and neck. (niasha.ch)
PURITO2
Herb5
- Abstract: DESCRIPTION (provided by applicant): Centella asiatica (L.) Urban herb (CA), is a medhya-rasayana (nerve rejuvenating) herb from the Ayurvedic tradition, used as a memory enhancer and nerve tonic. (nih.gov)
- PUBLIC HEALTH RELEVANCE: This project will explore the mechanisms and active compounds underlying the ability of the herb, Centella asiatica, to improve cognitive function. (nih.gov)
- Results from this study will lead to the development of standardized products of Centella asiatica which can be used in clinical trials of the herb as a treatment for cognitive decline in te elderly. (nih.gov)
- Centella asiatica (CeA) is a creeping herb, growing in moist places in India and other Asian Countries. (medscape.com)
- We will be working with a single herb, Centella asiatica (CA). (nih.gov)
Toner2
- Aan te brengen na het aanbrengen van een toner en vóór een serum. (boozyshop.nl)
- Centella Unscented Toner: Disperse the product on the skin and let it absorb. (niasha.ch)
Extracts2
- Centella Asiatica extracts are widely used for their traditional herbal remedy and culinary uses and have been used in Ayurveda for a very long time. (factmr.com)
- In vitro antibacterial and cytotoxic activity of leaf extracts of Centella asiatica (L.) Urb, Warburgia salutaris (Bertol. (biomedcentral.com)
LIGHT CLEANSING OIL2
- Skin1004 presents CENTELLA LIGHT CLEANSING OIL, a lightweight, oil-based cleanser designed to gently melt away makeup, dirt, oils, and sunscreen without stinging the eyes. (dearlucy.us)
- Experience the gentle and effective cleansing power of Skin1004's CENTELLA LIGHT CLEANSING OIL, leaving your skin clean, refreshed, and free from impurities. (dearlucy.us)
Serum2
- Centella Unscented Serum: Apply 3 - 4 drops of the product and gently massage/tap it until full absorption. (niasha.ch)
- This serum formulated with Centella Asiatica has healing and rejuvenating properties. (mellowmorning.nl)
Hydrocotyle1
- Espèce hydrocotyle vulgaris aussi utilisée que le Centella asiatica. (kajuard-plantes.com)
Apiaceae2
- however, recent studies utilising molecular data place Centella within Apiaceae. (wikipedia.org)
- Centella asiatica (L.) Urban, Family Apiaceae. (nih.gov)
Skin8
- A number of companies including Himalaya, SD Biotechnologies Co., Ltd. Nutricare Co., Ltd. Pairs of Horses Biotechnology Co., Ltd. Elishacoy are some of the companies using Centella Asiatica in their skin and personal care products. (factmr.com)
- For example, In India, Centella Asiatica is known as Mandukparni, and is used in skin treatment, memory enhancement, and anxiety whereas in Southeast Asia it is used for treating a number of skin diseases, joint-related disorders, and mental-health-related disorders. (factmr.com)
- Asian Centella, an effective "all in one" treatment for cellulite, skin rejuvenation, hair loss and stretch marks. (mnvmedical.com)
- Asian Centella ampoules, improves circulation (especially in areas affected by cellulite), it strengthens the skin and stimulates connective tissue. (mnvmedical.com)
- A soothing sheet mask with Centella Asiatica that instantly calms and moisturizes irritated skin. (coreelle.com)
- On days where skin feels exceptionally dry or irritated, apply another layer of Red Centella Balm before going to bed. (themedicube.com.sg)
- A. Red Centella Balm is best moisturizer for sensitive skin. (themedicube.com.sg)
- Extracted from Centella Asiatica, which is rich in amino acids, beta carotene, fatty acids, and phytochemicals for the skin, including powerful anti-aging properties. (coscorea.com)
Urban1
- Centella asiatica (Centella asiatica Linn Urban) is commercialized for multiple conditions. (nih.gov)
India2
- Centella Asiatica product price in India ranges from 180 to 20,00,000 INR and minimum order requirements from 1 to 3,000. (tradeindia.com)
- Centella asiatica is a perennial, herbaceous creeper with kidney shaped leaves, native to India, China, and found in shady, moist ground garden corner. (health32.com)
Water1
- crumple fresh centella leaves to get centella water only, add some sugar and salt to taste, then bring to a boil for about 10 minutes. (health32.com)
Medicinal2
- C. Panathula, M. Mahadev and C. Naidu, "The Stimulatory Effects of the Antimicrobial Agents Bavistin, Cefotaxime and Kanamycin on In Vitro Plant Regeneration of Centella asiatica (L.)-An Important Antijaundice Medicinal Plant," American Journal of Plant Sciences , Vol. 5 No. 3, 2014, pp. 279-285. (scirp.org)
- In our quest to find new antimicrobial agents with potent anticancer activity, the biological potential of leaves from the three medicinal plants Centella asiatica , Warburgia salutaris and Curtisia dentata as used by Zulu traditional healers for the treatment of cancer is investigated. (biomedcentral.com)
Rats3
- Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats. (medscape.com)
- Hypocholesterolemic effect of Centella asiatica in rats fed a high-cholesterol diet. (supaveda.com)
- Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health parameters in male rats. (supaveda.com)
ECHINACEA1
- Most trials are in simulated flight conditions and have a high risk of bias, including studies looking at the effectiveness of Centella asiatica , elderberry, echinacea, pinokinase, and diets containing various levels of fiber, fluids, or macronutrients. (cdc.gov)
Wound1
- One more benefit of Centella is wound healing. (health32.com)
Product1
- Laat je e-mailadres achter en we sturen je een mailtje wanneer dit product weer op voorraad is. (boozyshop.nl)
Herbal remedies1
- For Vietnamese, Centella asiatica becomes familiar as a herbal remedies for many common ailments. (health32.com)
Selections1
- We offer a wide range of Centella Asiatica selections in various locations including Delhi, Bengaluru, Mumbai, Hyderabad, Kolkata and many more. (tradeindia.com)