Cerebral Small Vessel Diseases
Leukoaraiosis
Brain Infarction
Stroke, Lacunar
Leukoencephalopathies
Dementia, Vascular
Cerebrovascular Disorders
Magnetic Resonance Imaging
Microvessels
Brain
Nerve Fibers, Myelinated
CADASIL
Venules
Stroke
Cognition Disorders
Image Processing, Computer-Assisted
Prospective Studies
Risk Factors
Netherlands
Dementia, Multi-Infarct
Cohort Studies
Cerebral Infarction
Basal Ganglia Cerebrovascular Disease
Vascular pathology in the aged human brain. (1/41)
(+info)Diffusion tensor imaging and cognition in cerebral small vessel disease: the RUN DMC study. (2/41)
(+info)Vascular inflammation in cerebral small vessel disease. (3/41)
(+info)Arterial stiffness and cognitive decline in well-functioning older adults. (4/41)
(+info)Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. (5/41)
(+info)The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? (6/41)
(+info)Frontal and temporal microbleeds are related to cognitive function: the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. (7/41)
(+info)Angiogenic T-cells and putative endothelial progenitor cells in hypertension-related cerebral small vessel disease. (8/41)
(+info)Cerebral small vessel diseases (CSVD) are a group of conditions that affect the small blood vessels in the brain. These diseases are characterized by the damage to the small arteries, arterioles, venules, and capillaries in the brain. The damage can lead to various clinical symptoms and neuroimaging findings, such as cognitive impairment, mood changes, gait disturbances, and lacunar infarcts or white matter hyperintensities on brain imaging.
CSVD is a common cause of vascular dementia and contributes to age-related cognitive decline. The exact causes of CSVD are not fully understood, but risk factors include aging, hypertension, diabetes, smoking, and genetic factors. There is currently no cure for CSVD, but managing risk factors and controlling blood pressure can help prevent further damage and reduce the risk of stroke and dementia.
Leukoaraiosis is a medical term that describes the appearance of small-vessel disease in the brain, which can be seen on imaging studies such as MRI or CT scans. It is characterized by areas of increased signal intensity or lucency in the white matter of the brain, particularly in the periventricular and deep white matter regions. These changes are thought to be due to ischemic damage from reduced blood flow in the small vessels of the brain.
Leukoaraiosis is often associated with aging and is more common in people with certain risk factors such as hypertension, diabetes, smoking, and hyperlipidemia. It has been linked to an increased risk of cognitive decline, gait disturbances, and stroke. However, the relationship between leukoaraiosis and these outcomes is complex and not fully understood.
Brain infarction, also known as cerebral infarction, is a type of stroke that occurs when blood flow to a part of the brain is blocked, often by a blood clot. This results in oxygen and nutrient deprivation to the brain tissue, causing it to become damaged or die. The effects of a brain infarction depend on the location and extent of the damage, but can include weakness, numbness, paralysis, speech difficulties, memory loss, and other neurological symptoms.
Brain infarctions are often caused by underlying medical conditions such as atherosclerosis, atrial fibrillation, or high blood pressure. Treatment typically involves addressing the underlying cause of the blockage, administering medications to dissolve clots or prevent further clotting, and providing supportive care to manage symptoms and prevent complications.
A lacunar stroke, also known as a small deep infarct or "lacune," is a type of cerebral infarction that results from the occlusion of one of the penetrating arteries that supply blood to the deep structures of the brain. These strokes are typically caused by lipohyalinosis or fibrinoid necrosis of the small vessels, and they tend to occur in people with underlying cerebral small vessel disease.
Lacunar strokes are often clinically silent, meaning that they do not cause any noticeable symptoms. However, when symptoms do occur, they may include weakness or numbness on one side of the body, difficulty speaking or understanding speech, and problems with coordination or balance. These symptoms can be similar to those caused by other types of stroke, but lacunar strokes tend to affect deeper structures of the brain and are less likely to cause severe neurological deficits.
Diagnosis of a lacunar stroke typically involves imaging studies such as MRI or CT scans, which can show areas of damage in the deep white matter of the brain. Treatment for lacunar strokes is similar to that for other types of stroke and may include medications to prevent blood clots, manage risk factors such as high blood pressure and diabetes, and improve symptoms such as weakness or difficulty walking.
Leukoencephalopathies are a group of medical conditions that primarily affect the white matter of the brain, which consists mainly of nerve fibers covered by myelin sheaths. These conditions are characterized by abnormalities in the structure and function of the white matter, leading to various neurological symptoms such as cognitive decline, motor impairment, seizures, and behavioral changes.
The term "leukoencephalopathy" is derived from two Greek words: "leukos," meaning white, and "enkephalos," meaning brain. The suffix "-pathy" refers to a disease or suffering. Therefore, leukoencephalopathies refer specifically to diseases that affect the white matter of the brain.
There are various types of leukoencephalopathies, including genetic, metabolic, infectious, toxic, and immune-mediated forms. Some examples include multiple sclerosis, adrenoleukodystrophy, Alexander disease, Canavan disease, and Marchiafava-Bignami disease. The diagnosis of leukoencephalopathies typically involves a combination of clinical evaluation, imaging studies such as MRI, and sometimes genetic or laboratory testing to identify the underlying cause. Treatment depends on the specific type and severity of the condition and may include medications, dietary modifications, physical therapy, or supportive care.
Vascular dementia is a type of dementia that is caused by damage to the blood vessels that supply blood to the brain. This damage can result from conditions such as stroke, chronic high blood pressure, diabetes, or other diseases that affect the circulatory system. The interruption in blood flow to the brain can lead to damaged or dead brain cells, which can impair cognitive function and cause symptoms similar to those seen in other types of dementia, such as Alzheimer's disease.
The symptoms of vascular dementia can vary depending on the severity and location of the damage to the blood vessels. However, common symptoms include difficulties with memory, attention, and decision-making; problems with language and speech; changes in mood or behavior; and difficulty walking or performing other physical tasks. Vascular dementia is typically a progressive condition, meaning that the symptoms tend to worsen over time.
It's important to note that vascular dementia can coexist with other types of dementia, such as Alzheimer's disease, and this is known as mixed dementia. Proper diagnosis and management of underlying medical conditions that contribute to vascular dementia can help slow down the progression of cognitive decline and improve quality of life for individuals living with this condition.
Cerebrovascular disorders are a group of medical conditions that affect the blood vessels of the brain. These disorders can be caused by narrowing, blockage, or rupture of the blood vessels, leading to decreased blood flow and oxygen supply to the brain. The most common types of cerebrovascular disorders include:
1. Stroke: A stroke occurs when a blood vessel in the brain becomes blocked or bursts, causing a lack of oxygen and nutrients to reach brain cells. This can lead to permanent damage or death of brain tissue.
2. Transient ischemic attack (TIA): Also known as a "mini-stroke," a TIA occurs when blood flow to the brain is temporarily blocked, often by a blood clot. Symptoms may last only a few minutes to a few hours and typically resolve on their own. However, a TIA is a serious warning sign that a full-blown stroke may occur in the future.
3. Aneurysm: An aneurysm is a weakened or bulging area in the wall of a blood vessel. If left untreated, an aneurysm can rupture and cause bleeding in the brain.
4. Arteriovenous malformation (AVM): An AVM is a tangled mass of abnormal blood vessels that connect arteries and veins. This can lead to bleeding in the brain or stroke.
5. Carotid stenosis: Carotid stenosis occurs when the carotid arteries, which supply blood to the brain, become narrowed or blocked due to plaque buildup. This can increase the risk of stroke.
6. Vertebrobasilar insufficiency: This condition occurs when the vertebral and basilar arteries, which supply blood to the back of the brain, become narrowed or blocked. This can lead to symptoms such as dizziness, vertigo, and difficulty swallowing.
Cerebrovascular disorders are a leading cause of disability and death worldwide. Risk factors for these conditions include age, high blood pressure, smoking, diabetes, high cholesterol, and family history. Treatment may involve medications, surgery, or lifestyle changes to reduce the risk of further complications.
Medical Definition:
Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.
Microvessels are the smallest blood vessels in the body, including capillaries, venules, and arterioles. They form a crucial part of the circulatory system, responsible for delivering oxygen and nutrients to tissues and organs while removing waste products. Capillaries, the tiniest microvessels, facilitate the exchange of substances between blood and tissue cells through their thin walls. Overall, microvessels play a vital role in maintaining proper organ function and overall health.
The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:
1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.
The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.
Myelinated nerve fibers are neuronal processes that are surrounded by a myelin sheath, a fatty insulating substance that is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. This myelin sheath helps to increase the speed of electrical impulse transmission, also known as action potentials, along the nerve fiber. The myelin sheath has gaps called nodes of Ranvier where the electrical impulses can jump from one node to the next, which also contributes to the rapid conduction of signals. Myelinated nerve fibers are typically found in the peripheral nerves and the optic nerve, but not in the central nervous system (CNS) tracts that are located within the brain and spinal cord.
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a genetic disorder that affects the small blood vessels in the brain. It is caused by mutations in the NOTCH3 gene, which leads to the progressive degeneration of these vessels.
The symptoms of CADASIL typically begin in middle age and include migraine with aura, recurrent strokes or transient ischemic attacks (TIAs), cognitive decline, and psychiatric symptoms such as depression and apathy. The condition can also cause physical disabilities such as difficulty walking and urinary incontinence.
CADASIL is an inherited disorder, meaning that it is passed down from parent to child through a mutated gene. If one parent has the disease, each child has a 50% chance of inheriting the mutated gene and developing the condition. Currently, there is no cure for CADASIL, but treatments can help manage symptoms and improve quality of life.
Venules are very small blood vessels that carry oxygen-depleted blood from capillaries to veins. They have a diameter of 8-50 micrometers and are an integral part of the microcirculation system in the body. Venules merge together to form veins, which then transport the low-oxygen blood back to the heart.
A stroke, also known as cerebrovascular accident (CVA), is a serious medical condition that occurs when the blood supply to part of the brain is interrupted or reduced, leading to deprivation of oxygen and nutrients to brain cells. This can result in the death of brain tissue and cause permanent damage or temporary impairment to cognitive functions, speech, memory, movement, and other body functions controlled by the affected area of the brain.
Strokes can be caused by either a blockage in an artery that supplies blood to the brain (ischemic stroke) or the rupture of a blood vessel in the brain (hemorrhagic stroke). A transient ischemic attack (TIA), also known as a "mini-stroke," is a temporary disruption of blood flow to the brain that lasts only a few minutes and does not cause permanent damage.
Symptoms of a stroke may include sudden weakness or numbness in the face, arm, or leg; difficulty speaking or understanding speech; vision problems; loss of balance or coordination; severe headache with no known cause; and confusion or disorientation. Immediate medical attention is crucial for stroke patients to receive appropriate treatment and prevent long-term complications.
Cognitive disorders are a category of mental health disorders that primarily affect cognitive abilities including learning, memory, perception, and problem-solving. These disorders can be caused by various factors such as brain injury, degenerative diseases, infection, substance abuse, or developmental disabilities. Examples of cognitive disorders include dementia, amnesia, delirium, and intellectual disability. It's important to note that the specific definition and diagnostic criteria for cognitive disorders may vary depending on the medical source or classification system being used.
Cerebrovascular circulation refers to the network of blood vessels that supply oxygenated blood and nutrients to the brain tissue, and remove waste products. It includes the internal carotid arteries, vertebral arteries, circle of Willis, and the intracranial arteries that branch off from them.
The internal carotid arteries and vertebral arteries merge to form the circle of Willis, a polygonal network of vessels located at the base of the brain. The anterior cerebral artery, middle cerebral artery, posterior cerebral artery, and communicating arteries are the major vessels that branch off from the circle of Willis and supply blood to different regions of the brain.
Interruptions or abnormalities in the cerebrovascular circulation can lead to various neurological conditions such as stroke, transient ischemic attack (TIA), and vascular dementia.
Computer-assisted image processing is a medical term that refers to the use of computer systems and specialized software to improve, analyze, and interpret medical images obtained through various imaging techniques such as X-ray, CT (computed tomography), MRI (magnetic resonance imaging), ultrasound, and others.
The process typically involves several steps, including image acquisition, enhancement, segmentation, restoration, and analysis. Image processing algorithms can be used to enhance the quality of medical images by adjusting contrast, brightness, and sharpness, as well as removing noise and artifacts that may interfere with accurate diagnosis. Segmentation techniques can be used to isolate specific regions or structures of interest within an image, allowing for more detailed analysis.
Computer-assisted image processing has numerous applications in medical imaging, including detection and characterization of lesions, tumors, and other abnormalities; assessment of organ function and morphology; and guidance of interventional procedures such as biopsies and surgeries. By automating and standardizing image analysis tasks, computer-assisted image processing can help to improve diagnostic accuracy, efficiency, and consistency, while reducing the potential for human error.
Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.
Medical Definition:
"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.
I'm sorry for any confusion, but "Netherlands" is not a medical term. It is a country located in Western Europe, known for its artistic heritage, elaborate canal system, and legalized marijuana and prostitution. If you have any questions about medical terms or concepts, I would be happy to help with those!
Cerebral arteries refer to the blood vessels that supply oxygenated blood to the brain. These arteries branch off from the internal carotid arteries and the vertebral arteries, which combine to form the basilar artery. The major cerebral arteries include:
1. Anterior cerebral artery (ACA): This artery supplies blood to the frontal lobes of the brain, including the motor and sensory cortices responsible for movement and sensation in the lower limbs.
2. Middle cerebral artery (MCA): The MCA is the largest of the cerebral arteries and supplies blood to the lateral surface of the brain, including the temporal, parietal, and frontal lobes. It is responsible for providing blood to areas involved in motor function, sensory perception, speech, memory, and vision.
3. Posterior cerebral artery (PCA): The PCA supplies blood to the occipital lobe, which is responsible for visual processing, as well as parts of the temporal and parietal lobes.
4. Anterior communicating artery (ACoA) and posterior communicating arteries (PComAs): These are small arteries that connect the major cerebral arteries, forming an important circulatory network called the Circle of Willis. The ACoA connects the two ACAs, while the PComAs connect the ICA with the PCA and the basilar artery.
These cerebral arteries play a crucial role in maintaining proper brain function by delivering oxygenated blood to various regions of the brain. Any damage or obstruction to these arteries can lead to serious neurological conditions, such as strokes or transient ischemic attacks (TIAs).
Multi-infarct dementia (MID) is a specific type of dementia that is caused by multiple small strokes or mini-strokes (known as transient ischemic attacks or TIAs) in the brain. Also known as vascular dementia, multi-infarct dementia results from the interruption of blood flow to parts of the brain, leading to damage and death of brain tissue.
The term 'multi-infarct' refers to multiple areas (or infarcts) of damaged or dead tissue in the brain due to the lack of oxygen and nutrients caused by these small strokes. Over time, as more areas of the brain are affected, cognitive decline becomes apparent, leading to symptoms such as memory loss, difficulty with problem-solving, disorientation, language problems, and changes in mood or behavior.
Multi-infarct dementia is typically a progressive condition, meaning that symptoms worsen over time. However, the rate of progression can vary depending on factors such as the number and severity of strokes, underlying medical conditions, and lifestyle factors. It's important to note that multi-infarct dementia can be prevented or delayed by controlling risk factors for stroke, such as high blood pressure, diabetes, smoking, and high cholesterol.
A cohort study is a type of observational study in which a group of individuals who share a common characteristic or exposure are followed up over time to determine the incidence of a specific outcome or outcomes. The cohort, or group, is defined based on the exposure status (e.g., exposed vs. unexposed) and then monitored prospectively to assess for the development of new health events or conditions.
Cohort studies can be either prospective or retrospective in design. In a prospective cohort study, participants are enrolled and followed forward in time from the beginning of the study. In contrast, in a retrospective cohort study, researchers identify a cohort that has already been assembled through medical records, insurance claims, or other sources and then look back in time to assess exposure status and health outcomes.
Cohort studies are useful for establishing causality between an exposure and an outcome because they allow researchers to observe the temporal relationship between the two. They can also provide information on the incidence of a disease or condition in different populations, which can be used to inform public health policy and interventions. However, cohort studies can be expensive and time-consuming to conduct, and they may be subject to bias if participants are not representative of the population or if there is loss to follow-up.
Cerebral infarction, also known as a "stroke" or "brain attack," is the sudden death of brain cells caused by the interruption of their blood supply. It is most commonly caused by a blockage in one of the blood vessels supplying the brain (an ischemic stroke), but can also result from a hemorrhage in or around the brain (a hemorrhagic stroke).
Ischemic strokes occur when a blood clot or other particle blocks a cerebral artery, cutting off blood flow to a part of the brain. The lack of oxygen and nutrients causes nearby brain cells to die. Hemorrhagic strokes occur when a weakened blood vessel ruptures, causing bleeding within or around the brain. This bleeding can put pressure on surrounding brain tissues, leading to cell death.
Symptoms of cerebral infarction depend on the location and extent of the affected brain tissue but may include sudden weakness or numbness in the face, arm, or leg; difficulty speaking or understanding speech; vision problems; loss of balance or coordination; and severe headache with no known cause. Immediate medical attention is crucial for proper diagnosis and treatment to minimize potential long-term damage or disability.
Basal ganglia cerebrovascular disease refers to a type of stroke or brain injury that affects the basal ganglia, which are clusters of nerve cells located deep within the brain. These structures play a crucial role in controlling movement and coordination.
Cerebrovascular disease occurs when blood flow to the brain is disrupted due to blockage or rupture of blood vessels. In the case of basal ganglia cerebrovascular disease, this disruption specifically affects the blood supply to the basal ganglia. This can result in damage to the nerve cells in this region and lead to various symptoms, depending on the severity and location of the injury.
Symptoms of basal ganglia cerebrovascular disease may include:
* Hemiplegia or weakness on one side of the body
* Rigidity or stiffness of muscles
* Tremors or involuntary movements
* Difficulty with coordination and balance
* Speech and language difficulties
* Changes in cognitive function, such as memory loss or difficulty with problem-solving
Treatment for basal ganglia cerebrovascular disease typically involves addressing the underlying cause of the disrupted blood flow, such as through medication to control blood pressure or cholesterol levels, surgery to remove blockages or repair ruptured blood vessels, or rehabilitation therapy to help manage symptoms and improve function.
Brain ischemia is the medical term used to describe a reduction or interruption of blood flow to the brain, leading to a lack of oxygen and glucose delivery to brain tissue. This can result in brain damage or death of brain cells, known as infarction. Brain ischemia can be caused by various conditions such as thrombosis (blood clot formation), embolism (obstruction of a blood vessel by a foreign material), or hypoperfusion (reduced blood flow). The severity and duration of the ischemia determine the extent of brain damage. Symptoms can range from mild, such as transient ischemic attacks (TIAs or "mini-strokes"), to severe, including paralysis, speech difficulties, loss of consciousness, and even death. Immediate medical attention is required for proper diagnosis and treatment to prevent further damage and potential long-term complications.
Familial Danish dementia
Microangiopathy
Vascular bypass
Perivascular space
Lipohyalinosis
Joanna Wardlaw
Pseudoxanthoma elasticum
Lesional demyelinations of the central nervous system
Systemic vasculitis
Blood pressure
Cerebral atherosclerosis
Microinfarct
Reversible cerebral vasoconstriction syndrome
Charles Jacques Bouchard
Helene Benveniste
Porencephaly
David Werring
Anne Joutel
Montreal Cognitive Assessment
Charles Foix
NOTCH3
Elisabeth Tournier-Lasserve
Thrombotic storm
Interventional radiology
Stroke
Susac's syndrome
Intracerebral hemorrhage
Central sulcus
Boston criteria
Leducq Foundation
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
RePub, Erasmus University Repository: Intracranial arteriosclerosis is related to cerebral small vessel disease
Cerebral small vessel disease - preparing for RCT - Helsingfors universitet
Association of Neuroimaging Markers of Cerebral Small Vessel Disease With Short-Term Outcomes in Patients With Minor...
Small Vessel Disease and Ischemic Stroke Risk During Anticoagulation for Atrial Fibrillation After Cerebral Ischemia ...
7 Tesla MRI in Cerebral Small Vessel Disease - Nuffield Department of Clinical Neurosciences
Multi-shell Diffusion MRI Models for White Matter Characterization in Cerebral Small Vessel Disease
Cerebral hemodynamics in cerebral small vessel disease - Department of Psychiatry
Cerebral Small Vessel Disease burden is increased in Systemic Lupus Erythematosus<...
Read Cerebral Small Vessel Disease 2014
Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study. - Nuffield Department of Population...
Risk for MCI Up With Progressive Cerebral Small Vessel Disease - UWINHEALTH
Association of Blood Pressure Lowering Intensity With White Matter Network Integrity in Patients With Cerebral Small Vessel...
Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936<...
ISMRM 2022) A diffusion MRI tractometry approach in cerebral small vessel disease
High serum alkaline phosphatase in relation to cerebral small vessel disease<...
Small White Matter Lesion Detection in Cerebral Small Vessel Disease - Diagnostic Image Analysis Group
Dysfunctional effort-based decision making underlies apathy in genetic cerebral small vessel disease - SCNi
Endothelium and oxidative stress: The Pandora's Box of cerebral (and non-only) small vessel disease?
Neuroimaging studies on cognitive impairment due to cerebral small vessel disease | Stroke and Vascular Neurology
Familial Danish dementia - Wikipedia
COL4A1-related brain small-vessel disease: MedlinePlus Genetics
Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study<...
Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations | Stroke...
Cerebral small vessel disease genomics and its implications across the lifespan. - Munich Cluster for Systems Neurology - LMU...
Neurologic Effects of SARS-CoV-2 Transmitted among Dogs - Volume 29, Number 11-November 2023 - Emerging Infectious Diseases...
Correlation between total homocysteine and cerebral small vessel disease: A Mendelian randomization study. | Eur J Neurol;28(6...
Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. - Oxford Cardiovascular...
Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small...
The role of the fibrinolytic system laboratory markers in the assessment of the cerebral small vessel disease severity - PDF ...
Microbleeds13
- The prevalence of incident infarcts was 6.1 percent, incident cerebral microbleeds was 5.5 percent, progression of periventricular white matter hyperintensities was 22 percent, and progression of deep white matter hyperintensities was 48 percent, considering the progression of cSVD. (uwinhealth.com)
- We used quantile regression and logistic regression to evaluate the associations of ALP with white matter hyperintensities (WMH), cerebral infarct and cerebral microbleeds. (korea.ac.kr)
- No association was found between ALP and cerebral microbleeds. (korea.ac.kr)
- Conclusion: We found that higher serum levels of ALP are independently associated with WMH and cerebral infarct, but not with cerebral microbleeds. (korea.ac.kr)
- Currently, the Standards for Reporting Vascular changes on Neuroimaging criteria is widely applied to evaluate structural features seen on MRI, including recent small subcortical infarcts, lacunes, white matter hyperintensities, enlarged perivascular spaces, microbleeds and brain atrophy. (bmj.com)
- CSVD imaging markers, including lacunes, cerebral microbleeds, white matter hyperintensity, enlarged perivascular space and brain parenchymal fraction (BPF) were also assessed. (bvsalud.org)
- 3.0 T MRI was used to assess cSVD burden by combining four MRI markers including white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), perivascular spaces (PVS), and lacunes. (qxmd.com)
- MRI scans were performed within 7 days of stroke onset, and then neuroimaging markers of SVD including WMH, lacunes, cerebral microbleeds (CMB), and perivascular spaces (PVS), SVD burden scores were assessed. (biomedcentral.com)
- Subclinical brain magnetic resonance imaging (MRI) findings of presumed vascular origin, such as white matter hyperintensities, and those that have the appearance of infarcts, microbleeds, and microinfarcts are frequently observed in Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementia (ADRD) patients, as well as seemingly healthy older adults. (nih.gov)
- Cerebral microbleeds (CMB) on MRI are frequent in healthy aging individuals but precede ischemic and hemorrhagic stroke and dementia. (lu.se)
- Cerebral microbleeds (CMBs) are frequently found in the healthy elderly. (dovepress.com)
- The prevalence of cerebral microbleeds is similar to other countries. (dovepress.com)
- Cerebral microbleeds (CMBs) are 2-10mm, rounded or circular, well-defined hypointense lesions on gradient-echo T2*-weighted images (GRE T2*WI) or susceptibility-weighted images (SWI) of magnetic resonance imaging (MRI). (dovepress.com)
CSVD12
- A possible mechanism linking intracranial arteriosclerosis to cognitive impairment and dementia involves structural brain changes including cerebral small vessel disease (CSVD). (eur.nl)
- Joan Jiménez-Balado, from the Universitat Autònoma de Barcelona in Spain, and colleagues used data from a longitudinal population-based study on hypertensive patients aged 50 to 70 years to examine how changes in cerebral small vessel disease (cSVD) lesions relate to cognitive decline. (uwinhealth.com)
- However, cerebral small vessel disease (CSVD) accounts for about 50%-70% of VCI, which represented a more homogeneous subtype of VCI. (bmj.com)
- The term cerebral small vessel disease (CSVD) encompasses all the pathological processes that affect the small vessels of the brain, including small arteries and arterioles, and capillaries and small veins. (bmj.com)
- 1 2 Arteriolosclerosis (age-related or vascular risk-factor-related small vessel diseases) is sporadic and the most prevalent form of CSVD. (bmj.com)
- 3 4 CSVD has been proved as a slowly progressing disease that destroyed frontal-subcortical networks, leading to various frontal symptoms, especially the decreased executive and memory function with relatively reserved recognition. (bmj.com)
- 6 Furthermore, small vessels cannot be visualised in vivo and the pathological evidence of CSVD is also limited. (bmj.com)
- Common cerebral small vessel disease (cSVD) abnormalities are a common neuroradiological finding, especially in the elderly. (unipi.it)
- Cerebral small vessel disease (CSVD) is a clinical imaging syndrome with diverse etiology . (bvsalud.org)
- This study is aimed at investigating the association between the twenty-four-hour ambulatory blood pressure variability monitoring (ABPM) and cerebral small vessel disease (cSVD) burden in acute ischemic stroke (AIS) patients. (qxmd.com)
- MRI was performed at 3Tesla and cardiovascular risk factors (eg, age, smoking history, and hypertension), cerebral small vessel disease (CSVD) markers (eg, white matter hyperintensities, lacunar infarction, and enlarged perivascular space) and genetic information (eg, APOE, CR1) were recorded. (dovepress.com)
- 1 As one feature of cerebral small vessel disease (CSVD), CMBs were found to have a close association with ischemic or hemorrhagic stroke, dementia, or even mortality. (dovepress.com)
Stroke17
- BACKGROUND AND PURPOSE: The causes of recurrent ischemic stroke despite anticoagulation for atrial fibrillation are uncertain but might include small vessel occlusion. (ucl.ac.uk)
- We investigated whether magnetic resonance imaging markers of cerebral small vessel disease (SVD) are associated with ischemic stroke risk during follow-up in patients anticoagulated for atrial fibrillation after recent ischemic stroke or transient ischemic attack. (ucl.ac.uk)
- 75, diabetes, stroke, vascular disease, age 65-74, female score. (ucl.ac.uk)
- This study aimed to determine the association between SLE and features on neuroimaging of cerebral small vessel disease (SVD), a risk factor for stroke. (dundee.ac.uk)
- In people with COL4A1 -related brain small-vessel disease, the vasculature in the brain weakens, which can lead to blood vessel breakage and stroke . (medlineplus.gov)
- Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited. (ox.ac.uk)
- Mendelian randomization supports the causal association of extensive small vessel disease severity with increased risk of stroke and Alzheimer's disease. (ox.ac.uk)
- Sporadic human cerebral small vessel disease (SVD) commonly causes stroke & dementia but its pathogenesis is poorly understood. (ed.ac.uk)
- Association between Twenty-Four-Hour Ambulatory Blood Pressure Variability and Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke. (qxmd.com)
- Rationale: The pathophysiology of most lacunar stroke, a form of small vessel disease (SVD), is thought to differ from large artery atherothrombo- or cardio-embolic stroke. (ed.ac.uk)
- Genetic predisposition to higher HDL-C levels was associated with lower risk of small vessel stroke [odds ratio (OR) per standard deviation = 0.85, 95% confidence interval (CI) = 0.78-0.92] and lower WMH volume (β = -0.07, 95% CI = -0.12 to -0.02), which in multivariable Mendelian randomization remained stable after adjustments for LDL-C and triglycerides. (ox.ac.uk)
- Association estimates for intracerebral haemorrhage were negatively correlated with those for small vessel stroke and WMH volume across all lipid traits and lipoprotein particle components. (ox.ac.uk)
- HDL-C raising genetic variants in the gene locus of the target of CETP inhibitors were associated with lower risk of small vessel stroke (OR: 0.82, 95% CI = 0.75-0.89) and lower WMH volume (β = -0.08, 95% CI = -0.13 to -0.02), but a higher risk of intracerebral haemorrhage (OR: 1.64, 95% CI = 1.26-2.13). (ox.ac.uk)
- Genetic predisposition to higher HDL-C, specifically to cholesterol in medium-sized high-density lipoprotein particles, is associated with both a lower risk of small vessel stroke and lower WMH volume. (ox.ac.uk)
- Despite being a relatively common disease, the precise molecular mechanisms for the onset of ischemic stroke (IS) are still incompletely understood, with both environmental and genetic factors being implicated in this disease in a complex manner. (hindawi.com)
- We conducted a retrospective review of patients diagnosed with definite supratentorial recent small subcortical infarcts according to the ASCO classification with baseline and follow-up MRI (≥90 days of stroke onset). (frontiersin.org)
- Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as well as microvascular disorders leading to damage of the small blood vessels of the kidney (nephropathy), eye (retinopathy) and peripheral nerves (neuropathy). (lu.se)
Hypertension4
- White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. (synergy-munich.de)
- Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. (nature.com)
- CBAs were rare and predominantly seen in elderly individuals, many of whom had multiple systemic and cerebrovascular comorbidities including hypertension, myocardial and cerebral infarcts, and CAA. (nature.com)
- In primary ICH, hypertension is thought to be the underlying cause in 65% of cases, followed by cerebral amyloid angiopathy (CAA). (nature.com)
Brain26
- However, it remains under-explored whether plasma Aβ levels including novel Aβ1-38 relate to vascular brain disease and cognition in a preclinical-phase of dementiaObjective:To examine the association of plasma Aβ levels (i.e. (ox.ac.uk)
- In contrast there were no significant differences in individual MRI markers including DTI histogram metrics, brain volume or white matter hyperintensities.Discussion:Brain network analysis may be a sensitive surrogate marker in trials in small vessel disease. (ox.ac.uk)
- public-odp.nihr.ac.uk/QvAJAXZfc/opendoc.htm?document=crncc_users%5Cfind%20a%20clinical%20research%20study.qvw&lang=en-US&host=QVS%40crn-prod-odp-pu&anonymous=true)Classification of Evidence:This study provides Class II evidence that intensive BP lowering in patients with small vessel disease results in improved brain network function when assessed by DTI based brain network metrics. (ox.ac.uk)
- FDD patients also have extensive brain atrophy, particularly in the cerebellum, cerebral cortex, and white matter, as well as very thin and virtually demyelinated cranial nerves. (wikipedia.org)
- Surprisingly, a detailed anti-Aβ immunohistochemical survey of various brain areas from all available FDD autopsy cases clearly identified a co-deposited with ADan primarily in vascular and perivascular amyloid lesions, although co-deposition was also found on a smaller scale in parenchymal preamyloid deposits. (wikipedia.org)
- COL4A1 -related brain small-vessel disease is part of a group of conditions called the COL4A1 -related disorders. (medlineplus.gov)
- COL4A1 -related brain small-vessel disease is characterized by weakening of the blood vessels in the brain. (medlineplus.gov)
- People with COL4A1 -related brain small vessel disease also have leukoencephalopathy, which is a change in a type of brain tissue called white matter that can be seen with magnetic resonance imaging (MRI). (medlineplus.gov)
- Some people with COL4A1 -related brain small-vessel disease have an eye abnormality called Axenfeld-Rieger anomaly. (medlineplus.gov)
- Some individuals with COL4A1 -related brain small-vessel disease do not have any signs or symptoms of the condition. (medlineplus.gov)
- COL4A1 -related brain small-vessel disease is a rare condition, although the exact prevalence is unknown. (medlineplus.gov)
- As the name suggests, mutations in the COL4A1 gene cause COL4A1 -related brain small vessel disease. (medlineplus.gov)
- The COL4A1 gene mutations that cause COL4A1 -related brain small-vessel disease result in the production of a protein that disrupts the structure of type IV collagen. (medlineplus.gov)
- We observed substantial brain pathology in SARS-CoV-2-infected dogs, particularly involving blood-brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. (cdc.gov)
- Combined evidence from summary-based Mendelian randomization studies and profiling of human loss-of-function allele carriers showed an inverse relation between TRIM47 expression in the brain and blood vessels and extensive small vessel disease severity. (ox.ac.uk)
- We observed significant enrichment of Trim47 in isolated brain vessel preparations compared to total brain fraction in mice, in line with the literature showing Trim47 enrichment in brain endothelial cells at single cell level. (ox.ac.uk)
- Functional evaluation of TRIM47 by small interfering RNAs-mediated knockdown in human brain endothelial cells showed increased endothelial permeability, an important hallmark of cerebral small vessel disease pathology. (ox.ac.uk)
- Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life. (ox.ac.uk)
- Despite the frequency of subclinical brain imaging findings of presumed vascular origin, little is known about how they relate to cerebrovascular and other brain pathologies either during life or postmortem. (nih.gov)
- More recently, GAS5 inhibition was recognized as a modern therapeutic approach for ischemic brain damage due to its capability to reduce the neuronal apoptosis, abate the size of cerebral infarction, and improve neurological deficit [ 9 , 10 ]. (hindawi.com)
- A severemalaria syndrome in which infected red blood cells obstruct blood circulation in the small blood vessels in the brain and/or release cytokines that disrupt normal brain function. (cdc.gov)
- THURSDAY, Sept. 28, 2023 (HealthDay News) -- Being exposed to more estrogen throughout life -- or a longer reproductive life span -- may be good for the brain, according to new research that found a lower risk of cerebral small vessel disease in women who had more cumulative exposure. (msdmanuals.com)
- Cerebral small vessel disease happens from damage to small blood vessels in the brain. (msdmanuals.com)
- Researchers also gave them brain scans to look for cerebral small vessel disease by estimating white matter hyperintensities, which indicate injury to the brain's white matter. (msdmanuals.com)
- The American Brain Foundation has more on cerebral small vessel disease . (msdmanuals.com)
- Cerebral edema and deposition of calcium oxalate crystals in the walls of small blood vessels in the brain contribute to this CNS toxicity (Bey et al. (cdc.gov)
Sporadic3
- We included 50 patients with sporadic and 59 patients with genetically defined SVD (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL]) with cognitive testing and standardized 3T MRI, including multi-shell diffusion imaging. (nih.gov)
- The detection of short-term disease progression was assessed by linear mixed models in 49 patients with sporadic SVD with longitudinal high-frequency imaging (in total 459 MRIs). (nih.gov)
- In a cohort of 54 patients with sporadic cerebral small vessel disease, associations between diffusion MRI measures and processing speed were investigated both at low and high b-values, revealing complementary microstructural information. (ismrm.org)
Lacunes3
- We report a genome-wide association study and a whole-exome association study on a composite extreme phenotype of cerebral small vessel disease derived from its most common MRI features: white matter hyperintensities and lacunes. (ox.ac.uk)
- Lacunes may be confused with other empty spaces, such as enlarged perivascular (Virchow-Robbins) spaces, in which the specific small-vessel pathology is occasionally absent. (medscape.com)
- Lacunes are defined as small round or oval subcortical lesions with cerebrospinal fluid (CSF) isointense cavity on MRI ( 5 - 7 ), and often regarded as the consequence of previous recent small subcortical infarcts, so-called lacunar infarcts. (frontiersin.org)
20231
- 2023 Chronic kidney disease Chronic inflammation Glomerular filtration rate Oxidative stress Gut microbiota Immune system Dialysis Physical activity. (karger.com)
Dementia8
- White matter lesions (WML) are important markers for not only the small vessel disease, but also neuro-degenerative diseases including multiple sclerosis, AlzheimerAC/a,!a,,C/s disease and vascular dementia. (diagnijmegen.nl)
- Familial Danish Dementia is an extremely rare, neurodegenerative disease characterized by progressive cataracts, loss of hearing, cerebellar ataxia, paranoid psychosis, and dementia. (wikipedia.org)
- FDD is one of the two types of hereditary, cerebral amyloid angiopathy, alongside familial British dementia. (wikipedia.org)
- Healio (2/2, Gramigna) reports, "Severe cerebral small vessel disease, a common cause of vascular dementia, may be linked to apathy, fatigue and delirium," investigators concluded in an 81-study systematic review and meta-analysis that included 21,730 participants. (fuquacenter.org)
- Preventing Cognitive Decline and Dementia from Cerebral Small Vessel Disease: The LACI-1 Trial. (ed.ac.uk)
- Dive into the research topics of 'Preventing Cognitive Decline and Dementia from Cerebral Small Vessel Disease: The LACI-1 Trial. (ed.ac.uk)
- The purpose of this Alzheimer's Disease-Related Dementia (ADRD) initiative is to promote the development and distribution of innovative technologies, methods, protocols, and biomedical materials that enhance combined human neuropathology and neuroimaging research with data aimed at understanding the underlying pathophysiology of in vivo imaging results typically associated with vascular contributions to cognitive impairment and dementia (VCID) in TBI-related dementia and other ADRD diagnoses. (nih.gov)
- Described by Joutel et al , 3 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a Mendelian form of hereditary small-vessel disease and vascular dementia. (bmj.com)
Genome-wide2
- Seventeen population-based cohorts of older persons with MRI measurements and genome-wide genotyping (n = 41 326), whole-exome sequencing (n = 15 965), or exome chip (n = 5249) data contributed 13 776 and 7079 extreme small vessel disease samples for the genome-wide association study and whole-exome association study, respectively. (ox.ac.uk)
- The genome-wide association study identified significant association of common variants in 11 loci with extreme small vessel disease, of which the chr12q24.11 locus was not previously reported to be associated with any MRI marker of cerebral small vessel disease. (ox.ac.uk)
Infarcts5
- He found that most symptomatic lacunar strokes are due to the occlusion of penetrating arteries of 200-800 μm in diameter, whereas those with smaller-diameter penetrating artery infarcts tended to be asymptomatic. (medscape.com)
- Morphological changes of recent small subcortical infarcts are not well defined. (frontiersin.org)
- More than one-third of recent small subcortical infarcts do not lead to cavity formation and 40% of infarct lesions overlap with WMHs. (frontiersin.org)
- Our data indicate the continuity between recent small subcortical infarcts and WMHs. (frontiersin.org)
- In this study, we examined the long-term evolution of recent small subcortical infarcts by using MRI and identified the incidence of cavity formation, the infarct volume and diameter reduction, and the positional relationship between infarct lesions and WMHs. (frontiersin.org)
Lesions8
- With respect to SVD we conjecture that small lesions are important, as they have been observed to grow over time and they form the majority of lesions in number. (diagnijmegen.nl)
- To study these small lesions they need to be annotated, which is a complex and time-consuming task. (diagnijmegen.nl)
- Existing (semi)automatic methods have been aimed at volumetric measurements and large lesions, and are not suitable for the detection of small lesions. (diagnijmegen.nl)
- A number of features that were found to be well identifying small lesions were calculated including multimodal intensities, tissue probabilities, several features for accurate location description, a number of second order derivative features as well as multi-scale annular filter for blobness detection. (diagnijmegen.nl)
- Only small lesions were used to learn the target concept via Adaboost using random forests as its basic classifiers. (diagnijmegen.nl)
- FDD shares similar neuropathological characteristics with Alzheimer disease, including extensive cerebrovascular amyloidosis, parenchymal amyloid and preamyloid lesions, and neurofibrillary degeneration. (wikipedia.org)
- In the past decade, white matter lesions in the sense of cerebral microangiopathy have been identified as an important factor in gait disturbance and falls. (thieme-connect.com)
- The advent of disease-modifying medications appears to have significantly altered the course of MS. The administration of disease-modifying medications in the clinically isolated syndrome has been repeatedly demonstrated to delay the progression to clinically definite MS. [ 2 , 3 ] Not only may this therapy decrease relapse rates and new MRI lesions, but it may also reduce the development of confirmed disability. (medscape.com)
Intracranial2
- Cerebral small vascular disease (SVD) is an imaging, pathological and clinical syndrome caused by intracranial small vessel disease [ 1 ]. (biomedcentral.com)
- Flow velocity and pulsatility index were measured in the middle cerebral, basilar and intracranial internal carotid arteries of a sample of 141 diabetic patients with no other risk factors, and 132 age- and sex-matched healthy controls. (who.int)
Atherosclerosis2
Amyloid4
- Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study. (ox.ac.uk)
- Cerebral amyloid angiopathy in this disorder is severe. (wikipedia.org)
- Histopathologically FDD was characterized by severe cerebral amyloid angiopathy with neurofibrillary tangle deposition in the limbic system and the neocortex. (wikipedia.org)
- Many studies suggested that deep CMBs may relate to hypertensive small vessel disease (HTN-SVD) and strictly lobar CMBs for cerebral amyloid angiopathy (CAA), 1 but the risk factors of CMBs are not entirely clear. (dovepress.com)
Markers2
Occlusion1
- In particular, the lncRNA growth arrest-specific 5 (GAS5) was found upregulated in both middle cerebral artery occlusion (MCAO) rat models as well as in vitro cell models [ 9 ]. (hindawi.com)
Infarction1
- Total homocysteine (HCY) level might increase the risk of myocardial and cerebral infarction by damaging the vascular endothelium . (bvsalud.org)
Middle cerebr1
- The deep penetrating arteries are small, nonbranching end arteries (usually smaller than 500 μm in diameter), which arise directly from much larger arteries (eg, the middle cerebral artery, anterior choroidal artery, anterior cerebral artery, posterior cerebral artery, posterior communicating artery, cerebellar arteries, basilar artery). (medscape.com)
Biomarkers1
- How should we be using biomarkers in trials of disease modification in Parkinson's disease? (medscape.com)
Cognition and behavior1
- Cerebral circulation, cognition and behavior. (helsinki.fi)
Cerebrovascular disease1
- Previous research has shown that rates of cerebrovascular disease increase after menopause, which is often attributed to the absence of hormones," said study author Kevin Whittingstall , of the University of Sherbrooke in Quebec. (msdmanuals.com)
Common cause of vascular1
- about 25% of strokes are classified as small vessel, and SVD is the most common cause of vascular cognitive impairment. (ox.ac.uk)
Mendelian1
- Correlation between total homocysteine and cerebral small vessel disease: A Mendelian randomization study. (bvsalud.org)
Burden2
- Considering the number of patients infected with SARS-CoV-2, the neurologic signs can lead to a potential wave of neurodegenerative diseases, which could pose an immense burden on society. (cdc.gov)
- WMH and SVD burden may signify a diminished capacity of cerebral tissue to withstand ischemia. (biomedcentral.com)
Alzheimer's7
- Aβ1-40 and Aβ1-42 have been linked with risk of Alzheimer's disease. (ox.ac.uk)
- Together, the results demonstrate that aberrant astrocyte signaling can impair the major functional properties of the neurovascular unit (i.e., cerebral vessel regulation and synaptic regulation) and may therefore represent a promising drug target for treating VCID and possibly Alzheimer's disease and other related dementias. (uky.edu)
- and the Sylvia Mansbach Endowment for Alzheimer's Disease Research. (uky.edu)
- Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations. (medscape.com)
- The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease. (medscape.com)
- Under the 2011 National Alzheimer's Projects Act (NAPA), the first goal of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat ADRDs by 2025. (nih.gov)
- Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer's disease origin. (bvsalud.org)
Phenotype1
- We included only the patients with the presence of a highly likely ASCO phenotype S (for small vessel disease) graded 1 or 2 ( 12 ). (frontiersin.org)
Cognitive decline1
- Investigating cortico-striatal beta oscillations in Parkinson's disease cognitive decline. (medscape.com)
Neuroimaging1
- The terminology of the standards for reporting vascular changes on neuroimaging (STRIVE) ( 7 ) was used to describe the features of small vessel disease. (frontiersin.org)
Hypertensive1
- CBAs may not be a significant cause of ICH but are a manifestation of severe cerebral small vessel disease including both hypertensive arteriopathy and CAA. (nature.com)
Microangiopathy1
- The present review throws light on clinical presentations, makes a suggestion for classification, and describes relevant diagnostic and possible therapeutic strategies for gait disturbances and falls in elderly patients with cerebral microangiopathy. (thieme-connect.com)
Severe1
- Cerebral small vessel disease (SVD) is a major health problem, with estimated 250,000 persons in Finland with severe white matter changes. (helsinki.fi)
Parkinson's8
- This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
- This paper examines a hallmark symptom of Parkinson's disease, bradykinesia, aiming to elucidate its underlying causes, and emphasizing abnormal behavioral computations mediating motor impairment. (medscape.com)
- Might dopamine release deficits prior to neurodegeneration be a pathophysiological hallmark of Parkinson's disease? (medscape.com)
- The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)
- PTPA variants and the risk for Parkinson's disease in diverse ancestry populations. (medscape.com)
- Adult-onset neuronal intranuclear inclusion disease mimicking Parkinson's disease in a Chinese patient: a case report and literature reviews. (nel.edu)
- Wang Z, Guo J, Wang M, Wang Z, Hong D, Yu X. Adult-onset neuronal intranuclear inclusion disease mimicking Parkinson's disease in a Chinese patient: a case report and literature reviews. (nel.edu)
- The benefits and mechanisms of exercise training for Parkinson's disease. (nih.gov)
Carotid3
- Autophagy-related 16-like 1gene polymorphism, risk factors for cardiovascular disease and associated carotid intima-media thickness in postmenopausal women. (cdc.gov)
- Carotid artery disease in NIDDM diabetes. (who.int)
- Because these frequency figures are largely based on findings from renal studies, they may not reflect the distribution of FMD types in carotid disease. (medscape.com)
Pathophysiology1
- Overall, our comprehensive gene-mapping study and preliminary functional evaluation suggests a putative role of TRIM47 in the pathophysiology of cerebral small vessel disease, making it an important candidate for extensive in vivo explorations and future translational work. (ox.ac.uk)
Genetic3
- Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol. (ox.ac.uk)
- Here, we explored associations of genetic determinants of blood lipid levels, lipoprotein particle components, and targets for lipid-modifying drugs with small vessel disease phenotypes. (ox.ac.uk)
- Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration. (medscape.com)
Blood7
- The total SVD score was not associated with SLE activity, cognition, disease duration, or any blood measure. (dundee.ac.uk)
- The conditions in this group have a range of signs and symptoms that involve fragile blood vessels . (medlineplus.gov)
- Similar blood vessel weakness and breakage occurs in the eyes of some affected individuals. (medlineplus.gov)
- Accumulation of granular osmiophilic material within the tunica media is pathophysiologically characteristic of CADASIL, ultimately leading to luminal stenosis in long penetrating arteries supplying subcortical white matter with consequent and expected reduction in cerebral blood flow. (bmj.com)
- Cerebral blood flow in diabetes mellitus: evi- tions , 1996, 10:228-242. (who.int)
- Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. (cdc.gov)
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. (lu.se)
Circulation2
Neurodegenerative disease1
- Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between SARS-CoV-2-associated small vessel disease and neurodegeneration. (cdc.gov)
Artery1
- Phase contrast image showing atherosclerotic plaque formation (white dense area) at the bifurcation of a cerebral artery from ApoE KO mouse. (lu.se)
Lacunar1
- Another study suggests that by using a gene expression profile, small deep infarct (SDI) differences between lacunar and nonlacunar strokes can be distinguished. (medscape.com)
Progression3
- Several metrics from DTI and DKI performed similarly in detecting disease progression. (nih.gov)
- Objective: To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period of 9 years, distinguishing progression from regression. (utwente.nl)
- Repeated studies have convincingly demonstrated that early treatment is critical in decreasing the rate of disease progression and, therefore, establishing the diagnosis in a timely fashion and initiating treatment is imperative. (medscape.com)
Patients10
- Wang C, Gao J, Li M, Qi H, Zhao T, Zhang B, Zhou C, Fang S. Association of cognitive impairment and mood disorder with event-related potential P300 in patients with cerebral small vessel diseases Neuro Endocrinol Lett. (nel.edu)
- We used the ASCO classification ( 12 ) in order to select the patients with definite recent small subcortical infarct. (frontiersin.org)
- Among these, 984 patients were clinically diagnosed with definite or possible supratentorial recent small subcortical infarct. (frontiersin.org)
- Using this approach, we identified 537 patients with definite supratentorial recent small subcortical infarct as reported previously ( 13 ). (frontiersin.org)
- This study assessed its validity in determining cerebral small vessel disease in patients with type 2 diabetes mellitus. (who.int)
- Transcranial doppler may be useful in early diagnosis of cerebral small vessel disease in patients with type 2 diabetes mellitus. (who.int)
- La vitesse d'écoulement du flux sanguin et l'index de pulsatilité ont été mesurés dans les artères carotides internes intercrâniennes, les artères basilaires et cérébrales moyennes d'un échantillon de 141 patients diabétiques sans autre facteur de risque et de 132 témoins en bonne santé appariés pour l'âge et le sexe. (who.int)
- Les patients ont été répartis en deux groupes : 73 patients souffrant d'un diabète compliqué dans le premier groupe et 68 patients atteints d'un diabète non compliqué dans le deuxième groupe. (who.int)
- On the other hand, the availability of increasingly effective treatments for MS that are associated with greater risk and the potential for their earlier administration in the course of the disease raises the risk of serious harm being done to patients who have been misdiagnosed. (medscape.com)
- Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)