Chloracne
Acne Vulgaris
Dioxins
Tetrachlorodibenzodioxin
Dermatitis, Occupational
Encyclopedias as Topic
Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor. (1/4)
(+info)Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3,3',4,4'-tetrachloroazobenzene for 2 years. (2/4)
(+info)Proceedings of the 2010 National Toxicology Program Satellite Symposium. (3/4)
(+info)Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down. (4/4)
(+info)Chloracne is a skin condition characterized by the appearance of acne-like lesions, such as blackheads, whiteheads, cysts, and pustules. It is typically found on the face and upper body, including the cheeks, forehead, and back. Chloracne is caused by exposure to certain chemicals, most notably polychlorinated biphenyls (PCBs) and dioxins, which can cause hormonal disruption and lead to abnormal growth and development of the oil glands in the skin. It is a serious condition that requires medical treatment and can indicate exposure to harmful environmental pollutants.
Acne vulgaris is a common skin condition characterized by the formation of various types of blemishes on the skin, such as blackheads, whiteheads, papules, pustules, and cysts or nodules. These lesions typically appear on areas of the body that have a high concentration of sebaceous glands, including the face, neck, chest, back, and shoulders.
Acne vulgaris occurs when hair follicles become clogged with dead skin cells and excess oil (sebum) produced by the sebaceous glands. This blockage provides an ideal environment for bacteria, particularly Propionibacterium acnes, to multiply, leading to inflammation and infection. The severity of acne vulgaris can range from mild with only a few scattered comedones (blackheads or whiteheads) to severe cystic acne, which can cause significant scarring and emotional distress.
The exact causes of acne vulgaris are not fully understood, but several factors contribute to its development, including:
1. Hormonal changes during puberty, menstruation, pregnancy, or due to conditions like polycystic ovary syndrome (PCOS)
2. Genetic predisposition
3. Use of certain medications, such as corticosteroids and lithium
4. Excessive production of sebum due to overactive sebaceous glands
5. Accumulation of dead skin cells that clog pores
6. Bacterial infection (particularly Propionibacterium acnes)
7. Inflammation caused by the body's immune response to bacterial infection and clogged pores
Treatment for acne vulgaris depends on its severity and can include over-the-counter or prescription topical treatments, oral medications, chemical peels, light therapies, or even hormonal therapies in some cases. It is essential to seek professional medical advice from a dermatologist or healthcare provider to determine the most appropriate treatment plan for individual needs.
Dioxins are a group of chemically-related compounds that are primarily formed as unintended byproducts of various industrial, commercial, and domestic processes. They include polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and certain polychlorinated biphenyls (PCBs). Dioxins are highly persistent environmental pollutants that accumulate in the food chain, particularly in animal fat. Exposure to dioxins can cause a variety of adverse health effects, including developmental and reproductive problems, immune system damage, hormonal disruption, and cancer. The most toxic form of dioxin is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Tetrachlorodibenzodioxin (TCDD) is not a common medical term, but it is known in toxicology and environmental health. TCDD is the most toxic and studied compound among a group of chemicals known as dioxins.
Medical-related definition:
Tetrachlorodibenzodioxin (TCDD) is an unintended byproduct of various industrial processes, including waste incineration, chemical manufacturing, and pulp and paper bleaching. It is a highly persistent environmental pollutant that accumulates in the food chain, primarily in animal fat. Human exposure to TCDD mainly occurs through consumption of contaminated food, such as meat, dairy products, and fish. TCDD is a potent toxicant with various health effects, including immunotoxicity, reproductive and developmental toxicity, and carcinogenicity. The severity of these effects depends on the level and duration of exposure.
Occupational dermatitis is a specific type of contact dermatitis that results from exposure to certain substances or conditions in the workplace. It can be caused by direct contact with chemicals, irritants, or allergens present in the work environment. This condition typically affects the skin on the hands and forearms but can also involve other areas of the body, depending on the nature of the exposure.
There are two main types of occupational dermatitis:
1. Irritant contact dermatitis (ICD): This type occurs when the skin comes into direct contact with an irritating substance, leading to redness, swelling, itching, and sometimes blistering. Common irritants include solvents, detergents, oils, and other industrial chemicals.
2. Allergic contact dermatitis (ACD): This type is a result of an allergic reaction to a specific substance. The immune system identifies the allergen as harmful and mounts a response, causing skin inflammation. Common allergens include latex, metals (such as nickel), and certain plants (like poison ivy).
Prevention measures for occupational dermatitis include using appropriate personal protective equipment (PPE) like gloves, masks, and aprons, as well as practicing good hygiene, such as washing hands regularly and avoiding touching the face with contaminated hands. If you suspect you have developed occupational dermatitis, consult a healthcare professional for proper diagnosis and treatment.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Defoliants are chemical agents that cause plants to shed their leaves. They are often used in agricultural practices to facilitate harvesting, prevent the spread of disease, or improve the appearance of crops. In some cases, defoliants may also be used as a military tactic to destroy enemy crops and vegetation, denying cover and sustenance to enemy forces. The most well-known example of this is Agent Orange, a herbicide used during the Vietnam War. Prolonged or excessive exposure to chemical defoliants can have harmful effects on human health, including skin irritation, damage to the respiratory system, and potential long-term consequences such as cancer and reproductive issues.
Chloracne - Wikipedia
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Chloracne - Testiwiki
Chloracne Veterans Benefits | Disabled Vets
TYPES OF CHLORACNE IN SEVESO PEOPLE AND AHR GENETIC VARIABILITY - Dioxin 20XX International Symposium
38 CFR Appendix C to Part 4 - Appendix C to Part 4-Alphabetical Index of Disabilities | Electronic Code of Federal Regulations ...
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Agent Orange and New PACT Act Benefits for Vietnam Veterans - Military Connection
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NIOSHTIC-2 Search Results - Full View
Chlorinated Dibenzo-p-dioxins (CDDs) | Public Health Statement | ATSDR
Agent Orange Effects & Symptoms
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Industrial Injuries Advisory Council reports - GOV.UK
寻常痤疮 - 参考文献 | BMJ Best Practice
Effects of air pollution on the skin: A review - Indian Journal of Dermatology, Venereology and Leprology
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Environmental Timeline | Timetoast timelines
Memorandum: Accelerated Mortality Rates of Vietnam Veterans | S. Brian Willson
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Agent Orange and Prostate CancerAcneform disease1
- Chloracne or acneform disease. (clevelandclinic.org)
Oral antibiotics or isotretinoin1
- Dermatologists sometimes treat chloracne with oral antibiotics or isotretinoin. (hillandponton.com)
Exposure14
- Chloracne is an acne-like eruption of blackheads, cysts, and pustules associated with exposure to certain halogenated aromatic compounds, such as chlorinated dioxins and dibenzofurans. (wikipedia.org)
- Chloracne is particularly linked to toxic exposure to dioxins (byproducts of many chemical processes, including the manufacture of herbicides such as Agent Orange)-so much so that it is considered a clinical sign of dioxin exposure. (wikipedia.org)
- Chloracne is an inflammatory skin disease closely associated with exposure to the Agent Orange defoliant used in Vietnam or along the DMZ in Korea in the 1960s and 70s. (hillandponton.com)
- More generally, chloracne is usually caused by exposure to halogen aromatic hydrocarbons called dioxins one of which was a chemical associated with Agent Orange. (hillandponton.com)
- A high level of exposure over a short period of time, such as that incurred by U.S. military veterans in Vietnam, is known to cause chloracne among other conditions recognized by the VA. (hillandponton.com)
- Chloracne is closely associated with exposure to the Agent Orange defoliant in the Vietnam War and along the DMZ in Korea . (hillandponton.com)
- So much so that the VA presumes any documented chloracne cases within one year of exposure are service-related. (hillandponton.com)
- Exposure to Agent Orange can cause chloracne . (disabledvets.com)
- If you believe you have chloracne or another disorder related to Agent Orange exposure, contact a veterans' disability lawyer today. (disabledvets.com)
- Sadly, chloracne and other skin conditions are far from the only medical conditions linked to Agent Orange exposure. (disabledvets.com)
- If you have chloracne or other skin disorders due to Agent Orange exposure, you deserve compensation for your injuries. (disabledvets.com)
- Nick Edwards, a clinical scientist at Guy's and St Thomas' Hospital in London, said: "Chloracne is a side effect of dioxin exposure but I have not heard of dioxins being used as a malicious chemical agent in this way. (bbc.co.uk)
- PCB exposure in the womb or during lactation is also associated with decreased IQ and impaired psychomotor development, decreased immune function, altered liver enzyme and lipid levels, and skin disease (chloracne) (ATSDR 2000b). (ewg.org)
- Exposure to high concentrations of especially toxic dioxins can cause an acne-like condition known as chloracne which mainly affects the face and upper body, which may last several years after exposure. (findmeacure.com)
Dioxins2
- He said the marks on Mr Yushchenko were chloracne, an acute form of acne which can be caused by dioxins. (bbc.co.uk)
- Dioxins have been associated with a number of adverse effects in humans, including immune and enzyme disorders and chloracne, and they are classified as possible human carcinogens. (pops.int)
Aromatic hydrocarbons2
- It was only in the mid-1950s that chloracne was associated with aromatic hydrocarbons. (wikipedia.org)
- Chloracne is a far more specific effect of certain poly-halogenated aromatic hydrocarbons, such as the chlorodibenzodioxins, on the sebaceous follicle. (hse.gov.uk)
Seveso2
- citation needed] 193 cases of chloracne occurred in Seveso, Italy, in 1976 following an industrial accident in which up to a few kilograms of TCDD were released into the atmosphere. (wikipedia.org)
- The dose range where chloracne was reported in Seveso, was 800 to 56,000 ng/kg (TCDD in fat), but some persons with levels up to 10,000 ng/kg did not have chloracne. (opasnet.org)
Herbicides1
- Veterans who were exposed to herbicides, such as Agent Orange, during military service have an increased risk of developing chloracne and other skin disorders. (disabledvets.com)
Reproductive1
- They are believed to be a cause of reproductive problems and chloracne, an outbreak similar to acne. (processingmagazine.com)
Severe1
- Several of the inmates developed severe cases of chloracne and some developed blisters that, untreated, lasted four to seven months. (wikipedia.org)
Occurs1
- A threshold level above which chloracne occurs has not been established. (opasnet.org)
Liver1
- People who have been unintentionally exposed to large amounts of these chemicals have developed a skin condition called chloracne, liver problems, and elevated blood lipids (fats). (cdc.gov)
Systemic1
- At present, evidence suggests that the external dose of a chloracnegen required to cause chloracne is significantly lower than that needed to cause systemic disorders (changes in circulating blood lipid levels, porphyria or any form of neoplasia/tumour). (hse.gov.uk)
Condition3
- Chloracne is a chronic inflammatory condition that results from this persistence, in combination with the toxin's chemical properties. (wikipedia.org)
- Chloracne is very often seen in combination with hyperhidrosis (clammy, sweaty skin) and porphyria cutanea tarda (a skin condition of increased pigmentation, hair coarsening and blistering). (wikipedia.org)
- Chloracne is a presumptive condition. (hillandponton.com)
Dose1
- The severity and onset of chloracne may follow a typical asymptotic dose-response relationship curve. (wikipedia.org)
Resistant2
- However, chloracne itself can be highly resistant to any treatment. (wikipedia.org)
- Chloracne and chloracne lesions are stubbornly resistant to treatment. (hillandponton.com)
Major1
- His valuable contributions and discoveries in major area of Chloracne. (longdom.org)
Porphyria cutan1
- Chloracne is very often seen in combination with hyperhidrosis (clammy, sweaty skin) and porphyria cutanea tarda (a skin condition of increased pigmentation, hair coarsening and blistering). (wikipedia.org)
General malaise1
- Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, paresthesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. (nih.gov)
Immune and enzyme disorders1
- Dioxins have been associated with a number of adverse effects in humans, including immune and enzyme disorders and chloracne, and they are classified as possible human carcinogens. (pops.int)
Cysts5
- Chloracne is an acne-like eruption of blackheads, cysts, and pustules associated with exposure to certain halogenated aromatic compounds, such as chlorinated dioxins and dibenzofurans. (wikipedia.org)
- Chloracne is a rare skin condition consisting of blackheads, cysts, and nodules, which has been linked directly to dioxin exposure. (cck-law.com)
- In regards to chloracne, the toxic chemicals resulting from exposure concentrate in these glands, break down slowly, and change the skin glands into cysts. (cck-law.com)
- Symptoms of chloracne include excessive oiliness of the skin and the appearance of numerous blackheads, often accompanied by fluid-filled cysts and dark body hair. (cck-law.com)
- In 1937, 21 workers at the Dow plant in Midland were treated for cysts, kidney damage and Chloracne caused by their contact with TCDD, then an unknown agent. (fifthestate.org)
MADISH2
- 9. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. (nih.gov)
- There is a paucity of literature on the clinical manifestations and pathogenesis of chloracne/MADISH. (bvsalud.org)
Cirrhosis1
- The standardized mortality ratio (SMR) for cirrhosis of the liver in the total cohort, 1.84, was significantly higher than that of the chloracne subcohort, 1.51. (cdc.gov)
Symptoms1
- Two thousand hectares of contaminated soil and 200 people with symptoms of a rare dermatological disease, chloracne. (arnika.org)
Onset1
- The severity and onset of chloracne may follow a typical asymptotic dose-response relationship curve. (wikipedia.org)
Toxic1
- Dioxins and furans are highly toxic substances that cause cancer, diabetes, and chloracne. (bworldonline.com)
PCBs1
- A large dose of PCBs causes a skin disease called chloracne. (nih.gov)
Dioxin4
- Ukrainian President Viktor Yushchenko suffered from prominent facial chloracne and was diagnosed with dioxin poisoning in late 2004. (wikipedia.org)
- 6. Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne. (nih.gov)
- 18. Toward elucidation of dioxin-mediated chloracne and Ah receptor functions. (nih.gov)
- The disfiguring skin condition chloracne is another result of dioxin, and famously afflicted Ukrainian President Victor Yushchenko after he was poisoned in 2004. (ipen.org)
Chronic2
- Chloracne is a chronic inflammatory condition that results from this persistence, in combination with the toxin's chemical properties. (wikipedia.org)
- Chloracne, prostate cancer, chronic lymphocytic leukemia. (citywatchla.com)
Disorders1
- Occurrences of mental disorders correlated with severity of chloracne, but not TCDD concentration. (bmj.com)
Severity2
- illness rates increased with severity of chloracne and higher TCDD concentration within the chloracne subgroup. (bmj.com)
- DISCUSSION--For various conditions, increased illness episodes were seen among TCDD exposed employees compared with referents and were associated with either or both chloracne severity and back calculated TCDD concentration. (bmj.com)
TCDD4
- citation needed] 193 cases of chloracne occurred in Seveso, Italy, in 1976 following an industrial accident in which up to a few kilograms of TCDD were released into the atmosphere. (wikipedia.org)
- METHODS--A retrospective cohort morbidity study of 158 men first exposed to TCDD between 17 November 1953 and 16 November 1954 subdivided by chloracne state and back calculated TCDD blood lipid concentration, and 161 referents. (bmj.com)
- these diseases were not differentially distributed by chloracne state, but were increased in the high TCDD subgroup. (bmj.com)
- Several of these increases correlated with chloracne state and infections disease episodes increased with higher TCDD concentration as well. (bmj.com)
Occupational1
- Chloracne is often seen in people who have occupational contact with chlorinated pesticides, wood preservatives, and sealants. (nih.gov)
CYP1A12
- 3. Chloracne: a case series on cutaneous expression of CYP1A1 as diagnostic biomarker. (nih.gov)
- The results suggest that CYP1A1 in human skin is a diagnostic biomarker in chloracne, and was positive for all the patients in our sample. (bvsalud.org)
Result1
- Skin contact can result in minor skin rashes or an allergic reaction resulting in "chloracne. (tfwinsurance.com)
People1
- As panic about tear gas 'toxicity' spread after a Stand News reporter was diagnosed with chloracne, we asked Dan for a technical review of the many questions people had. (osinthk.org)
Workers1
- Of the 9,028 workers studied, 460 had been diagnosed with chloracne. (cdc.gov)
Medical1
- Meanwhile, local medical groups have raised concerns of dioxins released by tear gas canisters, especially after a front-line reporter was diagnosed with chloracne, according to HKFP . (cmc.edu)
Primary1
- Once chloracne has been identified, the primary action is to remove the patient and all other individuals from the source of contamination. (wikipedia.org)
Results1
- Chloracne normally results from direct skin contact with chloracnegens, although ingestion and inhalation are also possible causative routes. (wikipedia.org)