Collagen Diseases
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
Caplan Syndrome
Retropharyngeal Abscess
Lung Diseases, Interstitial
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders. (1/154)
BACKGROUND: It has been suggested that the humoral immune system plays a role in the pathogenesis of cryptogenic fibrosing alveolitis (CFA). Although circulating autoantibodies to lung protein(s) have been suggested, none of the lung proteins have been characterised. The purpose of this study was to determine the antigen to which the serum from patients with pulmonary fibrosis reacted. METHODS: The anti-A549 cell antibody was characterised in a patient with CFA using Western immunoblotting and immunohistochemical staining of A549 cells. As we identified that one of the antibodies against A549 cells was anti-cytokeratin 8, the expression of mRNA of cytokeratin 8 in A549 cells was evaluated. In addition, we attempted to establish an enzyme linked immunosorbent assay to measure the levels of anti-cytokeratin 8 antibody in the serum of patients with CFA and pulmonary fibrosis associated with collagen vascular disorders (PF-CVD). RESULTS: Initially two anti-A549 cell antibodies were detected in the serum of patients with pulmonary fibrosis, one of which was characterised as anticytokeratin 8 antibody by Western immunoblotting. We were able to establish an ELISA to measure anti-cytokeratin 8 antibody and found significantly higher levels in patients with CFA and PF-CVD than in normal volunteers, patients with sarcoidosis, pneumonia, and pulmonary emphysema. CONCLUSIONS: One of the anti-A549 cell antibodies in the serum of patients with CFA was against cytokeratin 8. The serum levels of anti-cytokeratin 8 antibody were increased in patients with CFA and PF-CVD. These results suggest that anticytokeratin 8 antibody may be involved in the process of lung injury in pulmonary fibrosis. (+info)Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings. (2/154)
The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts. (+info)Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia. (3/154)
Cytokeratin 19 fragment (CK19) levels in serum have already been documented as a useful tumour marker for lung cancer. In the present study, it was hypothesized that CK19 may be increased in the serum and epithelial lining fluid of the respiratory tract from patients with pulmonary fibrosis. CK19 was measured in the serum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis and the correlation between CK19 levels and clinical parameters evaluated. Nineteen patients diagnosed with idiopathic pulmonary fibrosis (IPF), eight with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), seven patients with acute interstitial pneumonia (AIP), and 10 normal smokers as a control group were studied. CK19 levels in sera of patients with IPF and patients with PF-CVD were significantly increased compared to those of normal smokers. CK19 levels in sera of patients with AIP were significantly increased compared to those of other groups. CK19 values in the BALF of patients with pulmonary fibrosis were significantly elevated compared to those of normal smokers. CK19 values in sera charged according to the progression or improvement of the acute lung injury. Immunohistochemical study using pulmonary tissues obtained from patients with AIP demonstrated that the hyaline membrane and proliferating type II pneumocytes were stained by anti-human cytokeratin 19 antibody. These data demonstrated that the measurement of cytokeratin 19 fragment is a useful parameter to evaluate the activity of lung epithelial cell damage and repair. (+info)Collagen dysplasia (cutaneous asthenia) in a cat. (4/154)
Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen. (+info)Report of five novel and one recurrent COL2A1 mutations with analysis of genotype-phenotype correlation in patients with a lethal type II collagen disorder. (5/154)
Achondrogenesis II-hypochondrogenesis and severe spondyloepiphyseal dysplasia congenita (SEDC) are lethal forms of dwarfism caused by dominant mutations in the type II collagen gene (COL2A1). To identify the underlying defect in seven cases with this group of conditions, we used the combined strategy of cartilage protein analysis and COL2A1 mutation analysis. Overmodified type II collagen and the presence of type I collagen was found in the cartilage matrix of all seven cases. Five patients were heterozygous for a nucleotide change that predicted a glycine substitution in the triple helical domain (G313S, G517V, G571A, G910C, G943S). In all five cases, analysis of cartilage type II collagen suggested incorporation of the abnormal alpha1(II) chain in the extracellular collagen trimers. The G943S mutation has been reported previously in another unrelated patient with a strikingly similar phenotype, illustrating the possible specific effect of the mutation. The radiographically less severely affected patient was heterozygous for a 4 bp deletion in the splice donor site of intron 35, likely to result in aberrant splicing. One case was shown to be heterozygous for a single nucleotide change predicted to result in a T1191N substitution in the carboxy-propeptide of the proalpha1(II) collagen chain. Study of the clinical, radiographic, and morphological features of the seven cases supports evidence for a phenotypic continuum between achondrogenesis II-hypochondrogenesis and lethal SEDC and suggests a relationship between the amount of type I collagen in the cartilage and the severity of the phenotype. (+info)Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (6/154)
OBJECTIVE: To clarify the differences in the clinical features between idiopathic interstitial pneumonia (IIP) and interstitial pneumonia associated with collagen vascular diseases (CVD-IP). METHODS: Symptoms, radiographic findings, pulmonary function, blood chemistry data including autoantibody, and bronchoalveolar lavage fluid (BALF) findings were compared using multiple logistic regression analysis. PATIENTS: The subjects were 44 patients clinically diagnosed with IIP and 33 patients with CVD-IP. RESULTS: The clinical features related to IIP were as follows: male sex, advanced age, past history of hypertension, presence of cough, exertional dyspnea, digital clubbing, an increased level of gamma-globulin, decreased lung volume on chest X-ray, and typical type according to the criteria for IIP on chest X-ray. Increased levels of rheumatoid factor and total cell number in BALF were related to CVD-IP. CONCLUSION: These findings are considered to be useful to differentiate IIP and CVD-IP. (+info)Role of carbohydrate antigens sialyl Lewis (a) (CA19-9) in bronchoalveolar lavage in patients with pulmonary fibrosis. (7/154)
BACKGROUND: It has been reported that carbohydrate antigen sialyl Lewis (a) (CA19-9) levels are elevated in serum as well as in bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis. However, the biological significance of CA19-9 is unclear. OBJECTIVE: The purpose of the present study was to evaluate correlations between CA19-9 levels in BALF and several biochemical as well as clinical parameters in patients with pulmonary fibrosis. In addition, biological functions of CA19-9 were also examined. METHODS: We studied 24 patients with a diagnosis of pulmonary fibrosis: 16 with idiopathic pulmonary fibrosis (IPF) and 8 with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD). In BALF, carbohydrate antigens sialyl Lewis (a) (CA19-9), elastase: alpha(1)-proteinase inhibitor complex (E-PI), hepatocyte growth factor (HGF), LDH, IgG, IgA, albumin, and cell differentiation were measured. We also evaluated the effects of CA19-9 on neutrophil functions. RESULTS: CA19-9/albumin levels in BALF significantly correlated with HGF/albumin, elastase/albumin, LDH/albumin, total number of alveolar macrophages, and total number of neutrophils. Purified CA19-9 had a chemotactic activity for neutrophils. In addition, neutrophil chemotactic activity to C5a, fMLP, and interleukin 8 was significantly stimulated after incubation with purified CA19-9. Furthermore, CA19-9 increased the expression of CD15s on neutrophils. CONCLUSIONS: Our data demonstrated (i) CA19-9 in BALF correlated with other markers of inflammation in pulmonary fibrosis, and (ii) CA19-9 can modify neutrophil functions. These results suggest that CA19-9 may play a role in the process of lung injury in patients with pulmonary fibrosis. (+info)Alternate-day prednisone therapy and human lymphocyte subpopulations. (8/154)
The mechanisms and kinetics of the immunosuppressive effects of alternate-day prednisone were investigated in a group of patients with a variety of inflammatory diseases receiving a range of alternate-day prednisone doses from 5 to 120 mg. Total circulating lymphocyte and monocyte counts, as well as proportions of lymphocyte subpopulations defined both by surface markers and by in vitro functional capacities, were studied. At 8 a. m. of the day on prednisone, just before drug administration, lymphocyte and monocyte counts, proportions of lymphocyte subpopulations, as well as in vitro lymphocyte blastogenic responses to various mitogenic and antigenic stimuli were normal. 4 h after the administration of prednisone, there was a profound lymphocytopenia and monocytopenia, with a differential depletion of thymus-derived lymphocytes as well as various functionally defined lymphocyte subpopulations. Lymphocyte kinetic studies using a radioactive chromium-labeled autologous lymphocytes showed that the lymphocytopenia was due predominantly to a transient depletion of the recirculating portion of the intravascular lymphocytepool. All these parameters returned to normal by 8 a.m. of the following day (off prednisone) and remained normal throughout the day. This very transient lymphocytopenia and monocytopenia after prednisone, with normal cell numbers, proportions, and functions throughout the remainder of the 2-day cycle, was associated with suppression of disease activity, yet did not affect cutaneous delayed hypersensitivity in these patients nor increase the likelihood of infectious complications. This drug-associated cyclic and transient monocytopenia and selective lymphocytopenia is best explained by a redistribution of recirculating lymphocytes to other body compartments, particularly the bone marrow. (+info)Collagen diseases, also known as collagen vascular diseases or connective tissue disorders, refer to a group of medical conditions characterized by abnormalities in the structure and function of collagen, a crucial protein that provides strength and integrity to various tissues such as skin, tendons, ligaments, blood vessels, and organs, leading to inflammation, impaired function, and sometimes severe complications.
Collagen diseases, also known as collagen disorders or connective tissue diseases, refer to a group of medical conditions that affect the body's connective tissues. These tissues provide support and structure for various organs and systems in the body, including the skin, joints, muscles, and blood vessels.
Collagen is a major component of connective tissues, and it plays a crucial role in maintaining their strength and elasticity. In collagen diseases, the body's immune system mistakenly attacks healthy collagen, leading to inflammation, pain, and damage to the affected tissues.
There are several types of collagen diseases, including:
1. Systemic Lupus Erythematosus (SLE): This is a chronic autoimmune disease that can affect various organs and systems in the body, including the skin, joints, kidneys, heart, and lungs.
2. Rheumatoid Arthritis (RA): This is a chronic inflammatory disease that primarily affects the joints, causing pain, swelling, and stiffness.
3. Scleroderma: This is a rare autoimmune disorder that causes thickening and hardening of the skin and connective tissues, leading to restricted movement and organ damage.
4. Dermatomyositis: This is an inflammatory muscle disease that can also affect the skin, causing rashes and weakness.
5. Mixed Connective Tissue Disease (MCTD): This is a rare autoimmune disorder that combines symptoms of several collagen diseases, including SLE, RA, scleroderma, and dermatomyositis.
The exact cause of collagen diseases is not fully understood, but they are believed to be related to genetic, environmental, and hormonal factors. Treatment typically involves a combination of medications, lifestyle changes, and physical therapy to manage symptoms and prevent complications.
Caplan syndrome is a rare condition characterized by the coexistence of coal workers' pneumoconiosis, or black lung disease, and rheumatoid nodules in the lungs, which can lead to pulmonary symptoms such as cough and shortness of breath.
Caplan syndrome, also known as Caplan's syndrome or pneumoconiosis with rheumatoid nodules, is a rare condition characterized by the presence of multiple round, well-circumscribed nodules in the lungs. These nodules are similar to those seen in rheumatoid arthritis and are typically found in individuals who have been exposed to coal dust or other types of mineral dust.
The syndrome was first described in 1953 by Dr. Anthony Caplan, a Welsh physician who observed the association between pneumoconiosis (a lung disease caused by inhaling mineral dust) and rheumatoid nodules in coal miners. The condition is most commonly seen in coal miners, but it has also been reported in other occupations with exposure to mineral dust, such as stone cutters and sandblasters.
Caplan syndrome is thought to occur when the immune system's response to mineral dust exposure triggers an inflammatory reaction that leads to the formation of rheumatoid nodules in the lungs. The presence of these nodules can cause symptoms such as cough, shortness of breath, and chest pain. In severe cases, Caplan syndrome can lead to lung scarring and decreased lung function.
Diagnosis of Caplan syndrome typically involves a combination of medical history, physical examination, imaging studies (such as chest X-rays or CT scans), and laboratory tests (such as blood tests for rheumatoid arthritis). Treatment may include medications to manage the symptoms of rheumatoid arthritis and reduce inflammation in the lungs. In some cases, surgery may be necessary to remove severely damaged lung tissue.
A retropharyngeal abscess is a deep neck infection characterized by the accumulation of pus in the potential space between the buccopharyngeal fascia and the alar fascia, usually occurring as a complication of upper respiratory tract infections or following trauma to the pharynx, often presenting with symptoms such as throat pain, difficulty swallowing, fever, and neck stiffness.
A retropharyngeal abscess is a deep neck infection involving the potential space between the buccopharyngeal fascia and the alar fascia, primarily located in the retropharyngeal space. This space extends from the base of the skull to the mediastinum and contains loose connective tissue, fat, and lymph nodes. The infection usually originates from an upper respiratory tract infection or a penetrating injury to the posterior pharyngeal wall.
The abscess can cause swelling and compression of surrounding structures, leading to potentially serious complications such as airway obstruction, mediastinitis, or sepsis if left untreated. Symptoms may include neck pain, difficulty swallowing, fever, drooling, and decreased appetite. Diagnosis is typically made through a combination of clinical examination, imaging studies (such as CT or MRI scans), and laboratory tests. Treatment usually involves surgical drainage of the abscess and antibiotic therapy to manage the infection.
Interstitial lung diseases (ILDs) refer to a diverse group of pulmonary disorders characterized by inflammation and/or fibrosis of the lung parenchyma, primarily affecting the interstitium, which can lead to progressive loss of lung function, impaired gas exchange, and architectural distortion.
Interstitial lung diseases (ILDs) are a group of disorders characterized by inflammation and scarring (fibrosis) in the interstitium, the tissue and space around the air sacs (alveoli) of the lungs. The interstitium is where the blood vessels that deliver oxygen to the lungs are located. ILDs can be caused by a variety of factors, including environmental exposures, medications, connective tissue diseases, and autoimmune disorders.
The scarring and inflammation in ILDs can make it difficult for the lungs to expand and contract normally, leading to symptoms such as shortness of breath, cough, and fatigue. The scarring can also make it harder for oxygen to move from the air sacs into the bloodstream.
There are many different types of ILDs, including:
* Idiopathic pulmonary fibrosis (IPF): a type of ILD that is caused by unknown factors and tends to progress rapidly
* Hypersensitivity pneumonitis: an ILD that is caused by an allergic reaction to inhaled substances, such as mold or bird droppings
* Connective tissue diseases: ILDs can be a complication of conditions such as rheumatoid arthritis and scleroderma
* Sarcoidosis: an inflammatory disorder that can affect multiple organs, including the lungs
* Asbestosis: an ILD caused by exposure to asbestos fibers
Treatment for ILDs depends on the specific type of disease and its underlying cause. Some treatments may include corticosteroids, immunosuppressive medications, and oxygen therapy. In some cases, a lung transplant may be necessary.
Collagen is the most abundant structural protein in the extracellular matrix and connective tissues, such as tendons, ligaments, skin, and bones, providing strength, resilience, and support to maintain tissue integrity and regeneration.
Collagen is the most abundant protein in the human body, and it is a major component of connective tissues such as tendons, ligaments, skin, and bones. Collagen provides structure and strength to these tissues and helps them to withstand stretching and tension. It is made up of long chains of amino acids, primarily glycine, proline, and hydroxyproline, which are arranged in a triple helix structure. There are at least 16 different types of collagen found in the body, each with slightly different structures and functions. Collagen is important for maintaining the integrity and health of tissues throughout the body, and it has been studied for its potential therapeutic uses in various medical conditions.
Collagen disease - Wikipedia
Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... Collagen disease, Autosomal dominant disorders, All stub articles, Musculoskeletal disease stubs). ... ISBN 0-8027-0449-2. Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public ... "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for ...
Collagen vascular disease: MedlinePlus Medical Encyclopedia
Some of these diseases are similar to each other. They may involve arthritis and inflammation of ... Some of these diseases are similar to each other. They may involve arthritis and inflammation of ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. ...
Collagen | Protein Folding and Human Disease | Biology | MIT OpenCourseWare
Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic...
Thirteen patients (19%) subsequently developed systemic manifestations of collagen vascular diseases (CVD) and were diagnosed ... Can interstitial pneumonia as the sole presentation of collagen vascular diseases be differentiated from idiopathic ... Thirteen patients (19%) subsequently developed systemic manifestations of collagen vascular diseases (CVD) and were diagnosed ...
What are the symptoms of collagen vascular disease? - Kyoto2.org
What is undifferentiated collagen vascular disease?. Collagen vascular diseases are autoimmune diseases that occur when the ... What are collagen vascular disorders?. Collagen vascular disease, also known as connective tissue disease, is a group of ... What diseases are associated with collagen?. A noteworthy group of maladies of unknown origin which primarily involve ... What is type 1 collagen?. Hydrolysed Marine Collagen Supplement Pills.Hyaluronic Acid Magnesium Vitamin C. Anti-Aging. Skin ...
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in...
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in ... Skin collagen AGE measurements obtained from stored specimens were related to clinical data from the DCCT/EDIC using Spearman ... Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular ... In contrast IMT was inversely associated with lower collagen pepsin solubility and positively with glucosepane,. CONCLUSIONS:. ...
Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid |...
Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid. ... The probability that patients with collagen vascular diseases (CVD) will develop fibrosis is unpredictable. Since changes in ... Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid ... Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid ...
Rice University lab encodes collagen - Program defines stable sequences for synthesis, could help fight disease, design drugs
In a development that could lead to better drug design and new treatments for disease ... ... The human body is proficient at making collagen. And human laboratories are getting better at it all the time. ... The ability to synthesize custom collagen could lead to better drug design and treatment of disease. The colored portion of the ... Rice University lab encodes collagen. Program defines stable sequences for synthesis, could help fight disease, design drugs. ...
Figures and data in Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion |...
The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of ... Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion. ... Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion ... Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion ...
AID 1634582 - Therapeutic anti-inflammatory activity in mouse model of collagen-induced arthritis disease assessed as effect on...
collagen disease - Siteman Cancer Center
Collagen Vascular Disease Basics and Symptoms - Fibromyalgia Women
... a vascular surgeon at the Ohio University explains the basics of the collagen vascular disease, including common symptoms. ... Tags: collagen disorders list, collagen vascular disease lung, collagen vascular disease mayo clinic ... Collagen Diseases. Historically, a heterogeneous group of acute and chronic diseases including rheumatoid arthritis, systemic ... Collagen Vascular Disease. Everybody knows what a heart attack is. But the same condition that causes a heart attack, ...
Collagen Vascular Disease/EDS | Center for Continuing Medical Education
Gain insight into the pthophysiology of Collagen Vascular Diseases/EDS.3. Discuss treatment modalities for Collagen Vascular ... Describe the main clinical features associated with Collagen Vascular Diseases/EDS.2. ... 2. Gain insight into the pthophysiology of Collagen Vascular Diseases/EDS.. 3. Discuss treatment modalities for Collagen ... 1. Describe the main clinical features associated with Collagen Vascular Diseases/EDS. ...
Dilated Cardiomyopathy: Practice Essentials, Background, Pathophysiology
Dilated cardiomyopathy is a progressive disease of heart muscle that is characterized by ventricular chamber enlargement and ... Cardiomyopathy associated with collagen-vascular disease. Several collagen-vascular diseases have been implicated in the ... Other infiltrative diseases that resemble hypertrophic/hypertensive heart disease include Danton disease, Friedreich ataxia, ... As with other diseases, authorities depend on reported cases (at necropsy or as a part of clinical disease coding) to define ...
Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease | BMC...
We examined the role of type I collagen (collagen I) and membrane bound type 1 MMP (MT1-MMP) on cyst development using both in ... collagen expression and metalloproteinases (MMPs) activity. We investigated the role of these increases on cystic disease ... We found that collagen concentration is critical in controlling the morphogenesis of MDCK cells cultured in 3D gels. MDCK cells ... Significantly, these cells began to form cyst when collagen I concentration reached to 1.2 mg/ml, and the ratios of cyst to ...
CME Activity | Collagen Vascular Disease Associated With Interstitial Lung | MDs & PAs
Collagen vascular disease-associated interstitial lung disease (CVD-ILD) consists of several immunologically mediated diseases ... Identify the collagen vascular diseases and their associated interstitial lung diseases.. *Describe and correlate the ... Explain the importance of the evaluation of collagen vascular disease-associated interstitial lung disease and its role in ... the interprofessional team to improve outcomes for patients with collagen vascular disease-associated interstitial lung disease ...
Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis...
Here, we introduce two types of novel methods for evaluation of voluntary behavior in a commonly used model of RA (collagen- ... Despite the better control of inflammation and joint deformity afforded by modern disease-modifying anti-rheumatic drugs, many ... is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor ... Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis ...
Collagen Disease Antibody Panel Cost in Delhi Test Price Near Me, India | GDIC
Collagen disease antibody panel test at low price from Ganesh Diagnostic & Imaging Centre. Fully Equipped labs. Highly ... Collagen Disease Antibody Panel The Collagen disease antibody panel aids in determining the production of collagen disease ... What is Collagen disease?. Collagen disease is the name of a cluster of diseases that affect the bodys connective tissues. It ... The Collagen disease antibody panel aids in determining the production of collagen disease antibodies used to identify ...
Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. - Immunology
Our objective in this study was to measure the kinetics of VEGF production in a murine model of collagen-induced arthritis and ... Synovial cells isolated from the knee joints of naive or sham-immunized mice, or from mice immunized with collagen but without ... Our data demonstrate that, in collagen-induced arthritis, expression of the potent angiogenic cytokine VEGF correlates with ... disease severity. Furthermore, specific blockade of VEGF activity results in attenuation of arthritis in both macroscopic and ...
Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease<...
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease. / Gjaltema, Rutger A. F.; ... Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease. Critical reviews in ... Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and diseaseFinal publishers version, 2 ... title = "Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease", ...
Cell-Based Collagen Company Looks To Disrupt Traditional Supply Chains For A Better World
Animal collagen is typically extracted by boiling animal carcasses leftover from slaughter. Jellatechs platform avoids this ... Ultimately, these diseases arent passed on through collagen products. But one has only to look at the destruction of the COVID ... Type 1 collagen is gram-for-gram stronger than steel. And, perhaps most importantly, all collagen types can interact with other ... Collagen, and its derivative, gelatin, are extremely valuable proteins. Collagen is one of the most important biological ...
2023 Collagen (GRS) Seminar GRC
The 2023 Gordon Research Seminar on Collagen (GRS) will be held in New London, NH. Apply today to reserve your spot. ... Altered Collagen Structure and Function in Relation to Disease Discussion Leader: Sophia Huang (University of Toronto, Canada) ... The Role of Mucosal Collagens in Perpetuating Chronic Inflammation in Inflammatory Bowel Disease ... Collagen and Collagen Assemblies Discussion Leader: Karanvir Saini (University of Pennsylvania, United States) ...
Frontiers | Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis
Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating ... as indicators of disease progression.ResultsOur findings demonstrated that CXCR4 targeting with CB significantly inhibited the ... and bone resorption leading to reduction of disease progression. These overall data show that targeting CXCR4 with CB-like ... of current therapies and clinical trials highlights the need of alternative strategies targeting monocytes to treat RA disease ...
Table 1 - Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan,...
Collagen diseases. 8 (6.0). Chronic lung diseases. 7 (5.3). HIV. 0. Chemotherapy. 12 (9.0). ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for ...
Lifeboat Foundation News Blog - Page 9191
Newly Discovered Features Of Collagen May Help Shed Light On Disease Processes Posted by Karen Hurst in categories: biotech/ ... Continue reading "Newly Discovered Features Of Collagen May Help Shed Light On Disease Processes" ยป. ... These observations revealed collagen fibrils have defects that spontaneously form and heal. In the presence of tension, such as ... In the NIH study, the scientists isolated individual, nano-sized collagen fibrils from rat-tail tendons. They then exposed the ...
Abdominal Examination: Overview, Preparation, Technique
Splenic trauma, extra-hepatic portal hypertension, splenic sequestration, hemolytic diseases, certain storage diseases ... Splenic trauma, extra-hepatic portal hypertension, splenic sequestration, hemolytic diseases, certain storage diseases ... avoidance of NSAIDs for acid peptic disease, compliance with pharmacologic regimens for inflammatory bowel disease, and a high- ... Signs of liver disease (tortuous abdominal vessels or jaundice) or pancreatic hemorrhage (Grey Turner and Cullen signs) may be ...
Mixed Connective Tissue Disease: Symptoms, Causes, and Treatment
It could be mixed connective tissue disease. Learn more about this rare autoimmune disease and how its treated. ... Collagen vascular disease is an autoimmune disease. Lupus, rheumatoid arthritis, and scleroderma are all types of collagen ... rarediseases.info.nih.gov/diseases/7051/mixed-connective-tissue-disease. *. Mixed connective tissue disease (MCTD). (2017).. ... Can Having Addison Disease Affect Your Life Expectancy?. If you have Addison disease, your life expectancy may be reduced due ...
Pediatric Asthma Differential Diagnoses
A Tale of Two Cases in Allergic Diseases: How Will You Treat These Patients With Asthma and Chronic Spontaneous Urticaria? 1.0 ... The effect of parental allergy on childhood allergic diseases depends on the sex of the child. J Allergy Clin Immunol. 2012 May ... A Tale of Two Cases in Allergic Diseases: How Will You Treat These Patients With Asthma and Chronic Spontaneous Urticaria? ... Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A study within the Danish ...