Conjunctival Diseases
Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva. (1/208)
In Stevens-Johnson syndrome, pathological keratinization of the ordinarily nonkeratinized corneal and conjunctival mucosal epithelia results in severe visual loss. We examined conjunctiva covering cornea in five eyes in the chronic cicatricial phase of Stevens-Johnson syndrome. Normal conjunctiva from five age-matched individuals was studied also. The number of epithelial cells in Stevens-Johnson syndrome conjunctiva that were immunoreactive with a monoclonal antibody, Ki-67, to a nuclear antigen found only in proliferating cells was greater than normal (93.8+/-19.8 cells above 100 basal cells versus 12.8+/-0.5 cells above 100 basal cells; P = 0.009). In addition, although clinical inflammation was mild, massive lymphocytic infiltration was seen in the substantia propria of conjunctiva covering cornea. In situ hybridization documented transglutaminase 1 (keratinocyte transglutaminase) mRNA in suprabasal cells of the abnormally thickened conjunctival epithelium in all Stevens-Johnson syndrome patients. In contrast, no message was detected in normal conjunctival or corneal epithelia. Transglutaminase 1 is expressed during the terminal differentiation of keratinocytes where it helps synthesize cornified cell envelopes. We speculate that in Stevens-Johnson syndrome, epithelial hyperproliferation, and transglutaminase 1 gene expression lead to the pathological keratinization of ocular surface mucosal epithelia. (+info)Ocular ochronosis in alkaptonuria patients carrying mutations in the homogentisate 1,2-dioxygenase gene. (2/208)
AIMS: To assess the involvement of the recently identified human homogentisate 1,2-dioxygenase gene (HGO) in alkaptonuria (AKU) in two unrelated patients with ochronosis of the conjunctiva, sclera, and cornea. METHODS: A mutation screen of the entire coding region of the HGO gene was performed using single stranded conformational analysis after polymerase chain reaction with oligonucleotide primers flanking all 14 exons of the HGO gene. Fragments showing aberrant mobility were directly sequenced. RESULTS: Two homozygous missense mutations, L25P and M368V, were identified, each of which leads to the replacement of a highly conserved amino acid in the HGO protein. CONCLUSIONS: The authors describe a novel mutation, L25P, in the German population and bring to 18 the total number of known HGO mutations. (+info)Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery. (3/208)
AIMS/BACKGROUND: To discover a more reliable method of performing delayed suture adjustment as a basis to investigate whether delayed adjustment actually provides more stable results. In order to prevent the formation of postoperative adhesions and delay the time of adjustment, an animal study was performed to determine the combined effect of physical barriers, Viscoat and Interceed, and a pharmacological agent, 5-fluorouracil (5-FU). METHODS: 38 rabbit eyes were divided into three groups. After recession of the superior rectus muscle (SRM), 5-FU was applied beneath and over the SRM in group 5-FU. Group I-f had Interceed and 5-FU and group I-fv, Interceed, 5-FU, and Viscoat. Delayed adjustment was performed once on each SRM at 1, 2, and 3 weeks postoperatively. The possible length and the necessary force to adjust as well as the degree of adhesions were recorded. RESULTS: 5-FU delayed the adjustment for up to 1 week after surgery in three out of four eyes. Combined use of Interceed and 5-FU could delay the adjustment for up to 1 week after surgery in three out of five eyes. Addition of Viscoat could delay the adjustment for up to 1 week after surgery in four out of five eyes. Adjustment was possible on only one of four eyes thereafter. CONCLUSIONS: Combined use of Interceed, 5-FU, and Viscoat could delay the adjustment in rabbits until 1 week postoperatively. (+info)Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. (4/208)
PURPOSE: To compare the effects of the three human isoforms of transforming growth factor (TGF)-beta in vivo using a mouse model of conjunctival scarring, both in normal eyes and after treatment with MMC, with a view to delineating the role of this growth factor in glaucoma filtration surgery. METHODS: Application of recombinant human TGF-beta was assessed in a prospective, randomized study of mouse conjunctival scarring, in which subconjunctival TGF-beta1, -beta2, and -beta3 (all 10(-9) M) were compared with control (phosphate-buffered saline [PBS] carrier) and mitomycin C (MMC; 0.4 mg/ml) treatment at 6 hours, and 1, 3, and 7 days after surgery (six eyes/treatment/time point). Effects of TGF-beta2 on eyes previously treated with MMC were also assessed. Histologic studies of enucleated eyes were performed to analyze development of the scarring response, extracellular matrix deposition, and the inflammatory cell profile. RESULTS: All three isoforms of TGF-beta behaved in a similar manner in vivo, being associated with a rapid-onset and exaggerated scarring response compared with control and MMC treatment. TGF-beta-treated eyes showed evidence of an earlier peak in inflammatory cell activity (P < 0.05) and increased collagen type III deposition (P < 0.05). TGF-beta2 treatment significantly stimulated scarring after MMC application (P < 0.05). CONCLUSIONS: TGF-beta1, -beta2, and -beta3 appear to have similar actions in vivo and stimulate the conjunctival scarring response. Application of TGF-beta2 modified the effects of MMC. All TGF-beta isoforms may be potent modulators of the conjunctival scarring response. These studies indicate that TGF-beta2 may naturally modify the antiscarring effects of antimetabolites such as MMC in glaucoma filtration surgery. (+info)Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent. (5/208)
PURPOSE: Currently available anti-scarring regimens for glaucoma filtration surgery have potentially blinding complications and thus the need for alternative and safer agents. The effects of a new antibody to transforming growth factor (TGF)-beta2 on in vitro and in vivo conjunctival scarring and after glaucoma filtration surgery were investigated. METHODS: The activity of a novel recombinant monoclonal neutralizing antibody (mAb) to human TGF-2 (rhAnti-TGF-beta2 mAb) was studied in conjunctival fibroblast-mediated proliferation, migration, and collagen contraction. Its safety in subconjunctival administration was assessed in vivo, and, in a rabbit model of glaucoma filtration surgery, its effects on conjunctival scarring and filtration surgery outcome were investigated. RESULTS: The rhAnti-TGF-beta2 mAb effectively inhibited TGF-beta2-mediated conjunctival scarring activity in vitro, at 50% inhibitory concentrations (IC50) of less than 1 nM. It significantly improved glaucoma filtration surgery outcome in an animal model of aggressive conjunctival scarring compared with control (P = 0.0291) and was clinically safe, nontoxic, and well tolerated after subconjunctival administration. CONCLUSIONS: Subconjunctival rhAnti-TGF-beta2 mAb treatment significantly affects surgical outcome and effectively reduces conjunctival scarring both in vitro and in vivo. It appears safe for subconjunctival administration and when compared with mitomycin-C treatment histologically, much less destructive to local tissue. rhAnti-TGF-beta2 mAb may have potential as a new anti-scarring agent for use in glaucoma filtration surgery. (+info)Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. (6/208)
PURPOSE: To correlate tear fluorescein clearance with interleukin-1alpha (IL-1alpha) concentration and gelatinase B (matrix metalloproteinase [MMP]-9) activity in the tear fluid of patients with ocular rosacea and normal control subjects. METHODS: Gelatinase activity was evaluated by gelatin zymography in tear fluid obtained from 13 patients with ocular rosacea (including 1 patient with recurrent epithelial erosion, 2 with recurrent peripheral corneal infiltrates and vascularization, and 2 patients with epithelial basement membrane dystrophy) and 13 normal subjects with normal aqueous tear production and no irritation symptoms. Tear fluorescein clearance was evaluated by measuring fluorescence in tear fluid collected from the inferior meniscus 15 minutes after instillation of 5 microl of 2% Na-fluorescein with a CytoFluor II fluorometer. Pro-MMP-9 and IL-1alpha concentrations in the tear fluid were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared with normal control subjects, patients with ocular rosacea had a greater delay of tear fluorescein clearance (P < 0.001), a higher tear IL-1alpha concentration (P < 0.001), and a greater pro-gelatinase B (92 kDa) activity (P < 0.001) in their tear fluid. The 84-kDa active form of gelatinase B was observed in 46% of the rosacea tear samples and none of the controls. The zymographic results were confirmed by ELISA that showed a significantly greater concentration of pro-MMP-9 (92 kDa) in the tear fluid of rosacea patients than controls. Delayed tear clearance was correlated with elevated tear IL-1alpha concentration (p=0.67, P < 0.001) and increased tear gelatinase B activity (p=0.84, P < 0.001). Tear IL-1alpha concentration was correlated with tear gelatinase B activity (p=0.58, P < 0.002). CONCLUSIONS: Gelatinase B (MMP-9) activity is greater in patients with ocular rosacea than in normal eyes. The majority of this activity is due to 92-kDa proform of this enzyme. This activity is correlated with delayed tear clearance and tear fluid concentration of interleukin-1alpha, a proinflammatory cytokine that has been reported to stimulate gelatinase B production. Elevated gelatinase B activity in ocular rosacea may be involved in the pathogenesis of the irritation symptoms, recurrent epithelial erosions, vascularization, and epithelial basement membrane dystrophy that develops in the corneas of patients with this condition. (+info)Overexpression of MMP-1 and MMP-3 by cultured conjunctivochalasis fibroblasts. (7/208)
PURPOSE: To determine whether conjunctivochalasis, denoting redundant, loose, nonedematous inferior bulbar conjunctiva, is associated with increased expression and activity of matrix metalloproteinases (MMPS) over their tissue inhibitors (TIMPs). METHODS: Expression of transcripts and proteins of MMPs, TIMPs, and urokinase plasminogen activator (uPA) by cultured normal human conjunctival and conjunctivochalasis fibroblasts was determined by Northern hybridization, enzyme-linked immunosorbent assay (ELISA), and Western blot analysis, respectively. Gelatin and casein zymography and quantitative collagenase activity assay were performed in the serum-free conditioned media. RESULTS: Compared with normal conjunctival fibroblasts from six subjects, conjunctivochalasis fibroblasts from eight patients showed markedly increased transcript expression of MMP-1 (5- to 32-fold) and MMP-3 (4 to 30-fold), whereas that of MMP-2, TIMP-1, TIMP-2, and uPA was similar between the two groups. Protein levels were increased in the serum-free conditioned media of conjunctivochalasis fibroblasts for MMP-1 (3.5- to 7.6-fold) and MMP-3 (2.3- to 13-fold), determined by ELISA and Western blot analysis. There was increased caseinolytic activity of MMP-3 and collagenolytic activity of MMP-1 (2.2-fold) by conjunctivochalasis fibroblasts, whereas no difference was noted between these two types of fibroblasts in the protein and gelatinolytic activity of MMP-2 or expression of TIMP-1 and TIMP-2 proteins, although that of TIMP-1 transcript was slightly higher in some conjunctivochalasis fibroblasts. No expression of MMP-9 was detected. CONCLUSIONS: Overexpression of MMP-1 and MMP-3 mRNA by conjunctivochalasis fibroblasts is correlated with their increased protein levels and proteolytic activities. Collectively, these data help explain how conjunctivochalasis manifests excessive degradation of the conjunctival matrix and Tenon's capsule. (+info)Key factors in the subjective and objective assessment of conjunctival erythema. (8/208)
PURPOSE: To establish objectively measurable characteristics of the conjunctival vasculature that correspond with the judgment of erythema by human observers. METHODS: Color images of bulbar conjunctiva from 21 subjects were digitally analyzed to extract the following variables characteristic of the scene: vessel width (W), number of vessels (V), proportion of area occupied by vessels (PA), relative redness both in vessels (RRV) and in the whole image (RRI), red-green difference both in vessels (RGV) and in the whole image (RGI), red-blue difference both in vessels (RBV) and in the whole image (RBI), and red hue value (RHV). These data were compared with subjective judgments by a panel of seven trained observers who independently rated erythema in the same images, using a 0 to 4 scale with decimal interpolation between grades. RESULTS: Correlation analysis indicated significant associations (P<0.05) between the mean response of the human observers and all the objective variables except RHV. Associations with the morphometric variables PA (R2 = 0.93) and V(R2 = 0.90) were markedly stronger than for the best colorimetric variable RBV (R2 = 0.62). CONCLUSIONS: Judgments of erythema made by human observers do not rely primarily on color but can be closely approximated by a univariate, linear model involving only the proportion of the scene occupied by vessels. Under the conditions of this study, grading of erythema by trained observers can be considered to constitute measurement to at least an interval level. (+info)Conjunctival diseases refer to a group of medical conditions that affect the conjunctiva, which is the thin, clear mucous membrane that covers the inner surface of the eyelids and the white part of the eye (known as the sclera). The conjunctiva helps to keep the eye moist and protected from irritants.
Conjunctival diseases can cause a range of symptoms, including redness, itching, burning, discharge, grittiness, and pain. Some common conjunctival diseases include:
1. Conjunctivitis (pink eye): This is an inflammation or infection of the conjunctiva that can be caused by viruses, bacteria, or allergies. Symptoms may include redness, itching, discharge, and watery eyes.
2. Pinguecula: This is a yellowish, raised bump that forms on the conjunctiva, usually near the corner of the eye. It is caused by an overgrowth of connective tissue and may be related to sun exposure or dry eye.
3. Pterygium: This is a fleshy growth that extends from the conjunctiva onto the cornea (the clear front part of the eye). It can cause redness, irritation, and vision problems if it grows large enough to cover the pupil.
4. Allergic conjunctivitis: This is an inflammation of the conjunctiva caused by an allergic reaction to substances such as pollen, dust mites, or pet dander. Symptoms may include redness, itching, watery eyes, and swelling.
5. Chemical conjunctivitis: This is an irritation or inflammation of the conjunctiva caused by exposure to chemicals such as chlorine, smoke, or fumes. Symptoms may include redness, burning, and tearing.
6. Giant papillary conjunctivitis (GPC): This is a type of allergic reaction that occurs in response to the presence of a foreign body in the eye, such as a contact lens. Symptoms may include itching, mucus discharge, and a gritty feeling in the eye.
Treatment for conjunctival diseases depends on the underlying cause. In some cases, over-the-counter medications or home remedies may be sufficient to relieve symptoms. However, more severe cases may require prescription medication or medical intervention. It is important to consult with a healthcare provider if you experience persistent or worsening symptoms of conjunctival disease.
Post-exposure prophylaxis (PEP) is the medical practice of using antiviral medications to prevent the development of a disease after an exposure to that disease. It is most commonly used in the context of preventing HIV infection, where it involves taking a combination of antiretroviral drugs for 28 days following potential exposure to the virus, such as through sexual assault or accidental needlestick injuries.
The goal of PEP is to reduce the risk of HIV infection by stopping the virus from replicating and establishing itself in the body. However, it is not 100% effective and should be used in conjunction with other preventative measures such as safe sex practices and proper use of personal protective equipment.
It's important to note that PEP must be started as soon as possible after exposure, ideally within 72 hours, but preferably within 24 hours, for it to be most effective. The decision to initiate PEP should be made in consultation with a medical professional and will depend on various factors such as the type of exposure, the risk of transmission, and the individual's medical history.
Symblepharon
Conjunctival suffusion
Tacrolimus
Conjunctivitis
Gundersen flap
Domestic rabbit
Kohl (cosmetics)
Marginal zone B-cell lymphoma
Allergic conjunctivitis
Conjunctival squamous cell carcinoma
Kawasaki disease
Fabry disease
Marburg virus disease
Limbal stem cell
Pacheco's disease
Eye disease
Graves' disease
Sickle cell retinopathy
Killer cell immunoglobulin-like receptor 2DL3
Pinguecula
Haemophilus influenzae biogroup aegyptius
List of ICD-9 codes 320-389: diseases of the nervous system and sense organs
List of ICD-9 codes 240-279: endocrine, nutritional and metabolic diseases, and immunity disorders
Xanthoma
Peripheral ulcerative keratitis
Tetrandrine
Equine recurrent uveitis
Corneal opacity
Rickettsia rickettsii
Varidnaviria
Inflammation12
- Relative contraindications to lr-CLAL include significant conjunctival inflammation and scarring, significantly decreased mucin, aqueous tear deficiency, and ocular surface keratinization. (aao.org)
- If there is significant conjunctival inflammation and scarring, a combination OSST may be more suitable (see below) [9] . (aao.org)
- Patients were evaluated pre- and postoperatively for conjunctival inflammation, conjunctival cicatrization, degree of keratopathy, and disease stage. (uveitis.org)
- Worse outcome was associated with chemotherapy intolerance or the presence of any preoperative conjunctival inflammation. (uveitis.org)
- Results indicate that after successful abolition of all conjunctival inflammation through chemotherapy, cataract surgery may be safely performed in patients with cicatricial pemphigoid. (uveitis.org)
- Ocular Mucous Membrane Pemphigoid (OcMMP) is a blinding immunobullous disease, characterised by auto-antibody driven conjunctival inflammation and scarring. (bham.ac.uk)
- The latter is commonly reported as a noninfectious acute inflammation of the anterior uveal tract and its adjacent structures, which may affect more than 20% of SpA patients representing the most common EAM of the disease [ 3 ]. (hindawi.com)
- Acute conjunctival inflammation in the newborn, usually caused by maternal gonococcal infection. (wakehealth.edu)
- Kawasaki disease is an unusual illness characterized by inflammation of blood vessels throughout the body. (kdfoundation.org)
- In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation subsides. (lambertvetsupply.com)
- Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (medscape.com)
- Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)
Conjunctivitis9
- Conjunctival suffusion is characterized by redness of the conjunctiva that resembles conjunctivitis, but it does not involve inflammatory exudates. (wikipedia.org)
- animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. (avma.org)
- Conjunctival cytology can help diagnose conditions such as conjunctivitis, allergies, and dry eye syndrome. (pathofast.com)
- Conclusion Conjunctival hyperemia, lid edema, and follicular conjunctivitis were observed in at least half of the patients with MIS-C, and those with ophthalmic involvement had a higher risk of cardiac involvement or severe disease. (thieme-connect.com)
- A history of severe conjunctivitis , chemical injury , Stevens-Johnson Syndrome (SJS) /Toxic Epidermal Necrolysis (TEN), and chronic use of ophthalmic solutions for glaucoma have been associated with conjunctival scarring consistent with non-progressive cicatrizing conjunctivitis. (eyewiki.org)
- Autoimmune etiologies including ocular rosacea with meibomian gland disease , atopic disease, and most commonly, ocular cicatricial pemphigoid (OCP) , part of the mucous membrane pemphigoid (MMP) spectrum of disorders, [4] have been implicated in active, progressive cicatrizing conjunctivitis. (eyewiki.org)
- The provider should be vigilant in eliciting a thorough history to better ascertain whether these findings of cicatrizing conjunctivitis reflect an active disease process. (eyewiki.org)
- As mentioned above, a spectrum of disease conditions can lead to cicatrizing conjunctivitis including autoimmune diseases, atopy, chemical burns, infectious causes, and malignancies. (eyewiki.org)
- purulent conjunctivitis, cervical lymphade- nopathy, skin rash, and oral mucosal and extremity changes characterize the disease. (who.int)
Conjunctiva7
- In all patients conjunctival epithelial involvement represented by bright roundish intracellular inclusions was evidenced, in both bulbar and tarsal conjunctiva. (arvojournals.org)
- The density and severity of conjunctival bright inclusions appeared more pronounced in tarsal than in bulbar conjunctiva. (arvojournals.org)
- However, the circulations of the bulbar conjunctiva and palpebral conjunctiva are linked, so both bulbar conjunctival and palpebral conjunctival vessels are supplied by both the ophthalmic artery and the external carotid artery, to varying extents. (wikipedia.org)
- With age, the conjunctiva can stretch and loosen from the underlying sclera, leading to the formation of conjunctival folds, a condition known as conjunctivochalasis . (wikipedia.org)
- and 4) the thin and flexible palpebral conjunctiva, which continues to the conjunctival fornix or conjunctival cul-de-sac. (merckvetmanual.com)
- Conjunctival cytology is a diagnostic test used to examine the cells on the surface of the conjunctiva, the transparent layer that covers the white part of the eye. (pathofast.com)
- The extensive conjunctival defect, involving one-half of the bulbar conjunctiva, was reconstructed with an amniotic membrane allograft. (nih.gov)
Diagnosis7
- OBJECTIVE To describe diagnosis, treatment, and outcome of and risk factors for ophthalmic disease in leopard geckos ( Eublepharis macularius ) evaluated at a veterinary teaching hospital. (avma.org)
- Use of a paper towel substrate, absence of any heat source, and lack of vitamin A supplementation were positively associated with a diagnosis of ophthalmic disease. (avma.org)
- This technique is used commonly to aid in the diagnosis of cervical disease. (medscape.com)
- Because Graves disease is an autoimmune disorder that also affects other organ systems, taking a careful patient history is essential to establishing the diagnosis. (medscape.com)
- A physician makes a diagnosis of Kawasaki Disease after carefully examining a child, observing signs and symptoms, and after ruling out the possibility of other diseases that can cause similar signs. (kdfoundation.org)
- The diagnosis of Kawasaki disease is clini- cal and based on the presence of fever and East Mazandaran is located in the north of at least 4 of the above-mentioned clinical the Islamic Republic of Iran. (who.int)
- Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)
Injection4
- Usually within a day or two of fever onset, bilateral bulbar conjunctival injection appears without exudate. (msdmanuals.com)
- On exam the patient has conjunctival injection, red cracked lips, swollen hands/feet, and an erythematous papular rash to her back. (emra.org)
- Bloodshot eyes (conjunctival injection), usually without discharge, develop during the first week of illness. (kdfoundation.org)
- There was an associated temporal conjunctival injection (Fig 1 ). (bmj.com)
Cytology8
- I optimised non-invasive Ocular Surface Impression Cytology (OSIC) combined with flow cytometry to characterise conjunctival leukocytes. (bham.ac.uk)
- Conjunctival cytology is a simple test that involves collecting cells from the surface of the eye to assess for any abnormalities or infections. (pathofast.com)
- Let's find out whether you need the Conjunctival Cytology test. (pathofast.com)
- Which symptoms are related to Conjunctival Cytology? (pathofast.com)
- People with chronic eye infections: Conjunctival cytology can be helpful in diagnosing the cause of chronic eye infections. (pathofast.com)
- Individuals with dry eye syndrome: Conjunctival cytology can also be useful in diagnosing dry eye syndrome, which is a condition where the eyes do not produce enough tears. (pathofast.com)
- Individuals with allergies: Conjunctival cytology can also be helpful in diagnosing allergies that affect the eyes. (pathofast.com)
- In which diseases is Conjunctival Cytology abnormal? (pathofast.com)
Symptoms5
- [ 3 , 4 ] Lymphoproliferative disease of the orbit usually presents later in life and causes symptoms due to gradually increasing mass effect. (medscape.com)
- This disease primarily affects a person's lungs, and its symptoms vary greatly. (cdc.gov)
- The disease is named after the Japanese pediatrician, Tomisaku Kawasaki, who described this particular pattern of signs and symptoms in 1967. (kdfoundation.org)
- Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (medscape.com)
- Also, partial presentations (an absence of some of the following signs/symptoms) do not necessarily imply less severe disease. (cdc.gov)
Melanoma9
- TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, NRAS Mutation, and NRAS Exon 3 Mutation are the most common alterations in conjunctival melanoma [ 2 ]. (mycancergenome.org)
- There is 1 clinical trial for conjunctival melanoma, of which 1 is open and 0 are completed or closed. (mycancergenome.org)
- Of the trial that contains conjunctival melanoma as an inclusion criterion, 1 is phase 2 (1 open). (mycancergenome.org)
- Avadomide and nivolumab are the most common interventions in conjunctival melanoma clinical trials. (mycancergenome.org)
- Eighty-six conjunctival melanocytic lesions from the Rotterdam Ocular Melanoma Study group were collected. (mendeley.com)
- To illustrate a novel method of management for extensive conjunctival and corneal melanoma. (nih.gov)
- A 40-year-old Caucasian woman presented with a large, diffuse conjunctival melanoma involving 6 clock hours of the limbus. (nih.gov)
- The conjunctival melanoma was completely resected microsurgically in one piece without disrupting the tumor. (nih.gov)
- Preliminary evidence suggests that combined therapeutic approaches, consisting of extensive tumor removal, cryotherapy, amniotic membrane allograft, and topical mitomyin C, can be effective in the management of diffuse conjunctival and corneal melanoma arising from primary acquired melanosis. (nih.gov)
Acute4
- Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
- The disease course is usually complicated by extra-articular manifestations (EAMs), such as psoriasis, inflammatory bowel disease (IBD), and acute anterior uveitis (AAU) [ 2 ]. (hindawi.com)
- Leptospirosis is an acute bacterial disease caused by Leptospires. (gov.tw)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its corresponding coronavirus disease (COVID-19) was first reported as a cluster of pneumonia cases in. (annals.edu.sg)
Infection5
- We describe a conjunctival exposure to WNV that occurred in the field and probably resulted in infection in the exposed person. (cdc.gov)
- Conjunctival suffusion may also occur in patients with a Hantavirus infection. (wikipedia.org)
- Leptospirosis , an infection with Leptospira, can cause conjunctival suffusion , which is characterized by chemosis, and redness without exudates. (wikipedia.org)
- The etiology of Kawasaki disease is unknown, but the epidemiology and clinical presentation suggest an infection or, more likely, an abnormal immunologic response to an infection in genetically predisposed children. (msdmanuals.com)
- Of approximately forty zoonotic diseases of agricultur al importance, six (Mycobacterium avium infection, erysipeloid, listerosis, conjunctival Newcastle infection, psittacosis, and dermatophytosis) are of concern to poultry workers. (cdc.gov)
Headache4
- Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. (medscape.com)
- [ 1 ] Headaches are frequently linked to pituitary disease, and it is generally accepted that headache is a common presenting feature of pituitary adenomas and other sellar pathologies. (medscape.com)
- However, any predisposition of a patient for primary headache will also contribute significantly to the development of headache in conjunction with pituitary disease. (medscape.com)
- All articles reporting original data and review articles on headache and pituitary disease in peer reviewed journals were screened for inclusion into the present review. (medscape.com)
Irritation1
- Inversion of the cilia (eyelashes) or facial hairs causes further discomfort, conjunctival and corneal irritation, and if protracted, corneal scarring, pigmentation, and corneal ulceration. (merckvetmanual.com)
Leptospira2
- Conjunctival suffusion is an eye finding occurring early in leptospirosis, which is caused by Leptospira interrogans. (wikipedia.org)
- Leptospira is long corkscrew-shaped bacteria, and may cause disease in humans by 277 serotypes divided into 25 serogroups. (gov.tw)
Malignant2
- The incidence of lymphoproliferative ocular diseases, especially malignant lymphoma, has increased over the years. (medscape.com)
- In conclusion ATRX loss and TERT promoter mutations are only found in (pre)malignant conjunctival melanocytic lesions, with most metastatic cases harboring one of these alterations, suggesting that both alterations are associated with adverse behavior. (mendeley.com)
Severity3
- Objective The aims of this study were to determine the prevalence and clinical features of ophthalmic involvement in multisystem inflammatory syndrome in children (MIS-C) and to evaluate its association with other organ system involvement and the severity of the disease. (thieme-connect.com)
- Patients may present in a variety of ways, depending on the severity of the disease process and the multitude of potential etiologies responsible for it. (eyewiki.org)
- If clinicians suspect leptospirosis in a patient, they should initiate treatment with antibiotics (e.g., doxycycline or penicillin) prior to receiving results of diagnostic tests, as earlier treatment is associated with a decrease in duration and severity of disease. (cdc.gov)
Keratoconjunctivitis1
- BACKGROUND: Atopic keratoconjunctivitis (AKC) is a chronic allergic conjunctival disease. (bvsalud.org)
Chemotherapy2
- Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). (avma.org)
- people with AIDS, the very old, the very young, and those receiving chemotherapy for immune-mediated diseases, organ transplantation, or neoplasia are examples of individuals that may be immunodeficient. (vin.com)
Manifestations2
- [ 8 ] However, oral manifestations at follow-up once disease is controlled may not be a marker for recurring intestinal disease. (medscape.com)
- Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
Chronic5
- Signs of this chronic progressive corneal disease include peripheral thinning and the formation of a perforation prone gutter. (bmj.com)
- According to the Centers for Disease Control and Prevention, more than 50 million people in the United States experience allergies each year, and allergies are the sixth leading cause of chronic illness. (crstodayeurope.com)
- Spondyloarthropathies (SpA) embrace different chronic inflammatory diseases sharing common genetic (association with HLA-B27 antigen) and clinical features. (hindawi.com)
- Diabetes is a chronic disease that affects both men and women. (apollosugar.com)
- Fissures or fistulas may occur in persons with chronic disease. (medscape.com)
Lesions4
- Invasive disease can be excluded, but intraepithelial lesions may not. (medscape.com)
- It is useful as a guide for where to obtain a biopsy specimen or resect ill-defined conjunctival lesions. (medscape.com)
- This study aimed to determine the prognostic value of ATRX loss in conjunctival melanocytic lesions. (mendeley.com)
- OBJECTIVE: We sought to evaluate whether the ocular lesions that FADS mice spontaneously develop are similar to those of patients with AKC and to estimate the efficacy of topical treatments with tacrolimus and betamethasone for FADS mice by using tear periostin, a novel biomarker for allergic conjunctival disease. (bvsalud.org)
Suffusion2
- About 30 percent of people with leptospirosis (also known as Weil's disease) develop conjunctival suffusion. (wikipedia.org)
- In a 1994 study of 17 patients with Hantavirus infections, 3 had conjunctival suffusion. (wikipedia.org)
Microscopic3
- To evaluate the microscopic corneal and conjunctival morhpology in patients with Fabry disease (FD) related keratopathy by using in vivo confocal microscopy (IVCM). (arvojournals.org)
- PURPOSE: To describe the microscopic corneal and conjunctival findings in patients with Fabry disease (FD) related keratopathy by using in vivo confocal microscopy. (unich.it)
- Samples can be sent to the Centers for Disease Control and Prevention (CDC) for confirmatory testing (PCR and confirmatory serologic testing by the microscopic agglutination test). (cdc.gov)
Atopic1
- detectable amounts of the enzymes also occurred in the tears of patients with keratoconus with associated atopic disease, patients undergoing treatment for herpetic eye disease, and patients with systemic and non-systemic dry eye disease. (bmj.com)
Epithelial2
- Epithelial cells do not demonstrate atypia, and dysplastic changes are uncommon for conjunctival inverted papillomas. (medscape.com)
- METHODS The experimental samples were obtained from the culture media of conjunctival and corneal epithelial cells, from fractionated blood plasma and leucocytes of healthy subjects and patients with rheumatoid arthritis, and from the tears of healthy subjects and patients with a variety of anterior segment diseases. (bmj.com)
Infectious Diseases1
- Red Book: 2021-2024 Report of the Committee on Infectious Diseases , ed. 32, 2021. (msdmanuals.com)
Patients12
- IVCM examination was performed in twelve eyes of six patients affected by Fabry disease, belonging to two different families. (arvojournals.org)
- These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. (cdc.gov)
- Results -Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. (avma.org)
- Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. (avma.org)
- BACKGROUND/AIMS Matrix metalloproteinases (MMPs) accumulate in the tears of patients with active peripheral ulcerative keratitis (PUK) but it is unknown whether these enzymes have a central role in disease progression. (bmj.com)
- RESULTS The major MMPs that accumulate in the tears of patients with rheumatoid arthritis with active ocular disease are MMP-9 and a species of M r 116 000. (bmj.com)
- This approach helps me to build rapport with patients, improves their understanding of the disease process, strengthens their confidence in me as their eye care provider, and improves their adherence to a prescribed medication regimen. (crstodayeurope.com)
- AAU may affect more than 20% of SpA patients representing the most common extra-articular manifestation of the disease. (hindawi.com)
- The management of SpA has dramatically improved over the last decades due to the development of new treat-to-target strategies and to the introduction of biologic disease modifying antirheumatic drugs (bDMARDs), particularly tumor necrosis factor alpha inhibitors (TNFis), currently used for the treatment of nonresponder patients to conventional synthetic agents. (hindawi.com)
- In fact, a subset of patients with euthyroid Graves disease is described. (medscape.com)
- Rarely, patients may present in or develop Kawasaki Disease Shock Syndrome in which hypotension is present. (emra.org)
- Intraoral involvement in Crohn disease occurs in 8-29% of patients and may precede intestinal involvement. (medscape.com)
Ophthalmic6
- PROCEDURES Information from medical records was used to identify leopard geckos with ophthalmic disease, characterize cases, and determine risk factors for the presence of ophthalmic disease. (avma.org)
- RESULTS Of the 112 leopard geckos, 52 (46%) had ophthalmic disease (mainly corneal or conjunctival disease). (avma.org)
- Female geckos were less likely to have ophthalmic disease, and there was a positive association between increasing age and ophthalmic disease. (avma.org)
- Head dysecdysis was the only concurrent disorder significantly associated with ophthalmic disease. (avma.org)
- CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that ophthalmic disease is a common finding in leopard geckos. (avma.org)
- Although animals receiving supplemental vitamin A were less likely to have ophthalmic disease, further understanding is required regarding the metabolism of and nutritional requirements for vitamin A in leopard geckos. (avma.org)
Abnormalities2
- Eyelid disorders may be associated with facial and orbital abnormalities, specific breeds, and adjunct skin diseases, as well as with many systemic diseases. (merckvetmanual.com)
- We nistration of intravenous immunoglobulin undertook a retrospective review of the (IVIG) within the first 10 days of illness medical records of all cases with Kawasaki decreases the prevalence of coronary ar- disease referred, treated or discharged tery abnormalities (CAA) to 2%-5% [ 5-7 ]. (who.int)
Findings3
- Physical findings that are unique to Graves disease but not associated with other causes of hyperthyroidism include ophthalmopathy and dermopathy. (medscape.com)
- Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
- Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)
Pterygium1
- Shtein RM, Sugar A. Pterygium and conjunctival degenerations. (medlineplus.gov)
Epithelium1
- [6] Additional cells present in the conjunctival epithelium include melanocytes , T and B cell lymphocytes . (wikipedia.org)
Humans3
- Zoonotic diseases are defined as being common to, shared by, or naturally transmitted between humans and other vertebrate animals. (vin.com)
- Humans are unlikely to contract zoonotic diseases from contact with their healthy cats and so in most cases do not need to relinquish them. (vin.com)
- Humans acquire the disease through direct contact with urine from animals infected with leptospirosis or with urine-contaminated water or mud. (cdc.gov)
Coronavirus1
- Objectives: To compare vaccinated-side axillary lymph node uptake on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) after coronavirus disease-2019 (COVID-19) and influenza vaccination. (bvsalud.org)
Blood vessels1
- Hypertension is associated with an increase in the tortuosity of bulbar conjunctival blood vessels and capillary and arteriole loss. (wikipedia.org)
Allograft1
- Living-related conjunctival limbal allograft (lr-CLAL) is a type of ocular stem cell transplantation (OSST) that treats limbal stem cell deficiency (LSCD). (aao.org)
Centers for Dis3
Coronary2
- Kawasaki disease is a vasculitis, sometimes involving the coronary arteries, that tends to occur in infants and children between the ages of 1 year and 8 years. (msdmanuals.com)
- The immediate effects of Kawasaki disease may not be serious but, in some cases, long-term complications including damage to the coronary arteries (vessels that supply blood to the heart muscle) and heart muscle may result. (kdfoundation.org)
Lymphoma2
- Whereas Hodgkin lymphoma rarely causes ocular disease, non-Hodgkin lymphoma (NHL) is the most common type of ocular lymphoma. (medscape.com)
- Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. (avma.org)
Clinical3
- Because of the observed correlation between tear film MMP content and clinical evidence of PUK progression, it has been suggested that the zymographic visualisation of these enzymes in tears could be reliably used as a monitor of disease activity. (bmj.com)
- Affected dogs had clinical signs of retrobulbar disease and cytologic or histologic evidence of zygomatic sialadenitis. (avma.org)
- Informa- host factors, including age, sex and race, tion concerning demographic, clinical and influence the occurrence of the disease [ 9 ]. (who.int)
Morphology2
- Corneal and conjunctival morphology were assessed by using a Laser-Scanning confocal Microscope. (arvojournals.org)
- Corneal and conjunctival morphology were assessed by means of a scanning slit corneal confocal white-light microscopy and confocal laser-scanning microscope. (unich.it)
Illness3
- Of thses diseases, histoplasmosis may be the one most likely to cause serious illness in a poultry worker. (cdc.gov)
- Kawasaki disease is not a rare illness and the exact number of cases that occur in the United States has not been determined. (kdfoundation.org)
- Negative serologic test results from samples collected in the first week of illness do not rule out disease. (cdc.gov)
Tissue3
- Lr-CLAL transplants allogenic limbal and conjunctival tissue with goblet cells from a matched living relative. (aao.org)
- Prior to this, no study had utilized limbal tissue with a conjunctival carrier from a living donor, alongside systemic immunosuppression (cyclosporine A, in this case) to prevent graft rejection [3] [4] . (aao.org)
- This may be effected by autoimmune diseases that involve ocular tissue or by ocular diseases that induce an inflammatory response. (bmj.com)
Genes1
- A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
Tumor1
- Among biologic disease modifying antirheumatic drugs (bDMARDs), tumor necrosis factor alpha inhibitors (TNFis) are currently widely used for the treatment of SpA. (hindawi.com)
Kawasaki13
- Kawasaki disease is the leading cause of acquired heart disease in children. (msdmanuals.com)
- Children of Japanese descent have a particularly high incidence, but Kawasaki disease occurs worldwide. (msdmanuals.com)
- Kawasaki Disease and Multisystem Inflammatory Syndrome (MIS-C) can be challenging to distinguish. (emra.org)
- Kawasaki Disease (KD) is a systemic vasculitis of unknown etiology. (emra.org)
- The following are some of the questions most frequently asked by parents of children who have Kawasaki disease. (kdfoundation.org)
- The handout and information provided on this page were put together by the Kawasaki Disease Research Center at the University of California San Diego. (kdfoundation.org)
- What is Kawasaki disease? (kdfoundation.org)
- Since then, Kawasaki disease has been found to occur most frequently among Japanese children. (kdfoundation.org)
- We estimate that there are between 4,000-5,000 diagnosed cases of Kawasaki disease each year in the U.S. It is estimated that the disease attacks 15-20 out of every 100,000 children less than 5 years of age. (kdfoundation.org)
- To date, no cause of Kawasaki disease has been identified. (kdfoundation.org)
- When children with Kawasaki disease grow up, their children are at higher risk of developing KD. (kdfoundation.org)
- How does a doctor determine if a child has Kawasaki disease? (kdfoundation.org)
- ABSTRACT We conducted a retrospective review of all cases of Kawasaki disease admitted to the major referral centres in Sari, East Mazandaran from 1 November 1997 to 30 October 2002. (who.int)
Alterations1
- Although FD-related cornea verticillata due to glycosphingolipids accumulation is considered to be primarily a corneal disease, in vivo confocal microscopy showed structural alterations throughout the entire ocular surface epithelia. (arvojournals.org)
Severe disease1
- p = 0.012) more likely to have severe disease. (thieme-connect.com)
Membrane1
- The average thickness of the bulbar conjunctival membrane is 33 microns. (wikipedia.org)
Ocular diseases1
- Various ocular diseases and long-term use of topical corticosteroids have been know to cause corneal and scleral thinning. (lambertvetsupply.com)