Coronaviridae
Nidovirales
SARS Virus
Marburg Virus Disease
Marburgvirus
Encyclopedias as Topic
Hemorrhagic Fevers, Viral
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Hemorrhagic Fever, Ebola
In situ hybridization for the detection and localization of porcine epidemic diarrhea virus in the intestinal tissues from naturally infected piglets. (1/118)
Detection and localization of porcine epidemic diarrhea virus (PEDV) was studied by in situ hybridization with a nonradioactive digoxigenin-labeled probe in formalin-fixed, paraffin-embedded tissues from 10 naturally infected piglets. A 377-base pair cDNA probe for viral RNA encoding the membrane proteins of PEDV cell-culture-adapted strain V215/78 was generated by the reverse transcription polymerase chain reaction. In the retrospective study of pigs from herds with diarrhea, the 10 piglets naturally infected with PEDV had positive signals for PEDV by in situ hybridization. When intestinal tissues were hybridized with the PEDV probe, a strong signal was seen in the villus enterocytes of jejunum and ileum but not in the cecum and colon. Positive cells typically had dark brown reaction products in the cytoplasm. Scattered epithelial cells along the ileal Peyer's patches dome areas contained viral RNA. In one piglet, hybridization signal was also found in the duodenum. PEDV was not demonstrated in tissues outside of the intestinal tract. These findings indicate that jejunal and ileal villus enterocytes are the main target of PEDV replication during epizootic outbreaks of the disease. (+info)Viremia-associated ana-aki-byo, a new viral disease in color carp Cyprinus carpio in Japan. (2/118)
A new virus disease that displays dermal ulceration and high mortality has been occurring since 1996 in color carp Cyprinus carpio reared in warm water in Japan. In histological examinations, initial erosive lesions displayed necrosis, hemorrhage and fibrin deposition in the dermal loose connective tissue and were accompanied by the partial destruction of the epidermis. Developed ulcerative lesions involved the lateral musculature with bacterial invasions. In visceral organs, necrotic cells were observed in the hematopoietic tissue, the spleen and the intestinal tissues as well as in cardiac muscle fibers which showed no signs of bacterial invasion. Electron microscopy revealed corona-like virus particles in these necrotic cells. The necrotic cells of the hematopoietic tissue and the spleen were accompanied by the formation of tubular structures and crystalline inclusions. The putative virus was isolated and cultured in epithelioma papillosum cyprini (EPC) cells. Carp experimentally inoculated with the cultured virus showed virus transmission, and the same pathological signs of the disease and mortalities as in natural infections. (+info)The effects of coronavirus on human nasal ciliated respiratory epithelium. (3/118)
Human coronavirus (HCoV) accounts for 15-30% of common colds, but only one case report has described the effect of a coronavirus infection, that was asymptomatic, on human respiratory epithelium. The authors examined the effects of infection with HCoV on ciliary structure and function in healthy volunteers infected by intranasal inoculation with HCoV 229E. A further four volunteers were sham infected with ultraviolet-inactivated virus. Immediately before inoculation (day 0) and 3 days later (day 3), ciliated epithelium was obtained by brushing the inferior nasal turbinate. Ciliary beat frequency was determined and beat pattern analysed for evidence of dyskinesia (0=normal, 3=severely dyskinetic) using digital high-speed video photography. Ciliary ultrastructure was examined by transmission electron microscopy. Symptom diaries were kept for the duration of the study. All subjects inoculated with HCoV, including the three who did not develop symptoms of an upper respiratory tract infection, had disruption of their respiratory epithelium on day 3. Although there was no difference in the mean ciliary beat frequency between day 0 (11.3 Hz (95% confidence interval (CI): 8.6-14.0) and day 3 (9.4 Hz (95% CI 7.2-11.6)), there was a significant increase (p<0.05) in the ciliary dyskinesia score between day 0 (0.2 (95% CI 0-0.5)) and day 3 (1.1 (95% CI 0.5-1.7). In sham-infected subjects, no differences in epithelial integrity, or ciliary structure and function were found between day 0 and day 3. Inoculation of healthy volunteers with human coronavirus caused disruption of the ciliated epithelium and ciliary dyskinesia. This is likely to impair mucociliary clearance. Damage to the respiratory epithelium, due to human coronavirus infection, may occur without overt clinical symptoms. (+info)Monoclonal antibody-based immunohistochemical detection of porcine epidemic diarrhea virus antigen in formalin-fixed, paraffin-embedded intestinal tissues. (4/118)
An immunohistochemistry technique was developed for the diagnosis of porcine epidemic diarrhea virus (PEDV). The technique was tested on formalin-fixed, paraffin-embedded intestinal tissues from piglets naturally infected with PEDV. Five different monoclonal antibodies (MAbs) were tested in this study. PEDV antigen was consistently detected in the PLP (4% paraformaldehyde, 100 mM L-lysine dihydrochloride, 10 mM sodium m-periodate in phosphate-buffered saline)-fixed PEDV-infected Vero cells or formalin-fixed, paraffin-embedded intestinal tissues from piglets naturally infected with PEDV. The C9-2-2 MAb gave the strongest reactivity and least background staining, detecting 10 of 10 infected pigs. The positive reaction was cytoplasmic. Positive enterocytes were distributed over the tip and along the sides of atrophied or fused villi in the jejunum and ileum. Positive-staining cells were not detected in the crypts. No staining was observed in cecum and colon. No positive cells were observed when the C9-2-2 MAb was reacted with the tissue sections from noninfected piglets or from transmissible gastroenteritus virus (TGEV)- and rotavirus-infected piglets. The selected anti-PEDV MAbs tested on formalin-fixed, paraffin-embedded tissue sections are useful for diagnosis when virus isolation is not available. This method would be of particular value in countries where both PEDV and TGEV are epizootic and would aid in differentiating between PEDV and TGEV infection. (+info)Redistribution and reduction of interphotoreceptor retinoid-binding protein during ocular coronavirus infection. (5/118)
Inoculation of the neurotropic coronavirus mouse hepatitis virus strain JHM intravitreally or into the anterior chamber causes acute infection of the retinal pigment epithelium (RPE) and neural retina. Weeks later, many retinas have foci of moderate to severe atrophy. The effect of coronavirus infection (after intravitreal inoculation) was examined on interphotoreceptor retinoid-binding protein (IRBP), the glycolipoprotein in the interphotoreceptor matrix (IPM) thought to transport retinoids between the photoreceptors and the RPE. Changes in IRBP distribution accompanied virus-associated retinal pathology, including photoreceptor loss and RPE abnormalities. Immunohistochemistry on days 3 and 6 showed that IRBP had diffused into the neural retina away from the IPM. The IRBP became localized abnormally in the same areas as virus-induced lesions, shown by staining adjacent sections with a monoclonal antibody specific for the viral nucleocapsid protein. Moreover, the level of IRBP in isolated retinas, measured in an immunoslot-blot assay, decreased significantly by day 3 and remained low through day 23. This decrease was confirmed in eyecups isolated on day 6. It may be caused in part by loss of photoreceptors and diffusion of IRBP through the retina into the vitreous. These studies show that a virus may induce an acute, limited infection in the retina that can be cleared by the host. However, the infection initiated a series of events resulting in long-term reduction and redistribution of a critical photoreceptor protein. (+info)Epithelia-damaging virus infections affect vitamin A status in chickens. (6/118)
The effect of infection with infectious bronchitis virus (IBV) and reovirus (RV) on vitamin A status was investigated in chickens with a normal or marginal intake of vitamin A. At the age of 4 wk, chickens were infected with either IBV or RV, primarily affecting the respiratory or intestinal tract, respectively. Both viruses lowered plasma retinol levels significantly. The effect was more pronounced in chickens fed a diet marginally deficient in vitamin A than in those fed a diet adequate in vitamin A. Concentrations of retinol-binding protein, transthyretin and albumin in RV-infected chickens were also significantly lower than in noninfected chickens fed the same diets; in chickens infected with IBV, there was no effect. These results suggest that the reduced vitamin A status of IBV-infected chickens could be attributed to increased rate of utilization by tissues. In RV infection, this mechanism could be involved but impaired absorption of nutrients (including vitamin A) and direct loss of nutrients via the intestinal tract could also be important. (+info)Seroconversion of pigs in contact with dogs exposed to canine coronavirus. (7/118)
In order to determine if canine coronavirus (CCV) could be transmitted to pigs, two dogs were inoculated orally with virulent CCV. After 24 h, the dogs were moved to an isolation room that contained three three-day-old pigs. A wire mesh fence, allowing close contact between the animals, separated the dogs from the pigs. The dogs and pigs were observed for 14 days for clinical signs of disease. Samples of blood were obtained from dogs and pigs immediately before the dogs were inoculated with virus and 14 and 28 days later. The dogs developed mild clinical signs of an infection, but the pigs remained normal throughout the observation period. The dogs shed CCV for eight days after exposure. All three pigs developed neutralizing antibodies against CCV and transmissible gastroenteritis virus by 14 days after they were exposed to the dogs. (+info)Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells. (8/118)
The importance of N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) as a receptor determinant for bovine coronavirus (BCV) on cultured cells was analysed. Pretreatment of MDCK I (Madin Darby canine kidney) cells with neuraminidase or acetylesterase rendered the cells resistant to infection by BCV. The receptors on a human (CaCo-2) and a porcine (LLC-PK1) epithelial cell line were also found to be sensitive to neuraminidase treatment. The susceptibility to infection by BCV was restored after resialylation of asialo-MDCK I cells with Neu5,9Ac2. Transfer of sialic acid lacking a 9-O-acetyl group was ineffective in this respect. These results demonstrate that 9-O-acetylated sialic acid is used as a receptor determinant by BCV to infect cultured cells. The possibility is discussed that the initiation of a BCV infection involves the recognition of different types of receptors, a first receptor for primary attachment and a second receptor to mediate the fusion between the viral envelope and the cellular membrane. (+info)Coronaviridae Infections refer to diseases caused by viruses belonging to the Coronaviridae family, which typically result in respiratory and gastrointestinal symptoms, with notable examples including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the more recently emerged SARS-CoV-2 responsible for COVID-19.
Coronaviridae is a family of enveloped, positive-sense RNA viruses that cause various diseases in animals and humans. Human coronavirus infections most commonly result in mild to moderate upper respiratory tract illnesses, such as the common cold. However, two highly pathogenic coronaviruses have emerged in the past two decades: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). These viruses can cause severe and potentially fatal respiratory illnesses.
In general, coronaviruses are transmitted through respiratory droplets produced when an infected person coughs, sneezes, or talks. In some cases, people may become infected by touching a surface contaminated with the virus and then touching their mouth, nose, or eyes. Preventive measures include frequent handwashing, avoiding close contact with sick individuals, and practicing good respiratory etiquette (e.g., covering coughs and sneezes).
Treatment for coronavirus infections is primarily supportive, focusing on relieving symptoms and managing complications. For severe cases of SARS-CoV and MERS-CoV infections, antiviral medications and supportive care in an intensive care unit may be necessary. Vaccines have been developed to protect against SARS-CoV-2, the virus that causes COVID-19, and are being distributed globally.
Coronaviridae is a family of enveloped, positive-sense single-stranded RNA viruses that primarily infect mammals and birds, causing respiratory and gastrointestinal diseases, and includes four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus.
Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. They are named for the crown-like (corona) appearance of their surface proteins. Coronaviruses infect a wide range of animals, including mammals and birds, and can cause respiratory, gastrointestinal, and neurological diseases. Some coronaviruses, such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), can cause severe and potentially fatal illness in humans. The most recent example is SARS-CoV-2, which causes COVID-19.
Nidovirales is an order of enveloped, positive-strand RNA viruses that includes important pathogens of humans and animals, such as coronaviruses and arteriviruses, which are characterized by their unique nested set of subgenomic mRNAs and complex replication strategies.
Nidovirales is an order of viruses that includes important pathogens such as coronaviruses and arteriviruses. These viruses are characterized by their large, complex genomes and the production of nested sets of subgenomic mRNAs during replication. They have a positive-sense, single-stranded RNA genome and are enveloped. The name "Nidovirales" is derived from the Latin word "nidus," meaning "nest," which refers to the nested set of subgenomic mRNAs produced during replication.
Coronaviruses, which include well-known human pathogens such as SARS-CoV, MERS-CoV and SARS-CoV-2 (which causes COVID-19), primarily infect the respiratory tract and can cause a range of symptoms from mild cold-like illness to severe pneumonia.
Arteriviruses, on the other hand, mainly infect animals and are associated with diseases such as porcine reproductive and respiratory syndrome (PRRS) in pigs and simian hemorrhagic fever in non-human primates.
It's important to note that Nidovirales have a high potential for cross-species transmission, which can lead to the emergence of new viruses with the ability to infect humans and cause disease.
SARS virus, or Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), is a highly infectious and sometimes fatal respiratory illness caused by a positive-sense, enveloped, single-stranded RNA virus that originated in bats and spread to humans through an intermediate host, the palm civet, resulting in a global outbreak in 2002-2003.
Severe Acute Respiratory Syndrome (SARS) is a viral respiratory illness caused by the SARS coronavirus (SARS-CoV). This virus is a member of the Coronaviridae family and is thought to be transmitted most readily through close person-to-person contact via respiratory droplets produced when an infected person coughs or sneezes.
The SARS outbreak began in southern China in 2002 and spread to several other countries before it was contained. The illness causes symptoms such as fever, chills, and body aches, which progress to a dry cough and sometimes pneumonia. Some people also report diarrhea. In severe cases, the illness can cause respiratory failure or death.
It's important to note that SARS is not currently a global health concern, as there have been no known cases since 2004. However, it remains a significant example of how quickly and widely a new infectious disease can spread in today's interconnected world.
Marburg Virus Disease is an acute and often fatal viral hemorrhagic fever caused by the Marburg virus, primarily transmitted to humans through exposure to infected bats or consumption of contaminated food or contact with infected bodily fluids, characterized by severe symptoms including high fever, severe headache, muscle pain, diarrhea, vomiting, bleeding disorders, and multi-organ dysfunction.
Marburg Virus Disease (MVD) is an acute and often fatal viral hemorrhagic fever illness caused by the Marburg virus, a member of the filovirus family. It's a highly infectious disease that can be transmitted from human to human through direct contact with infected bodily fluids, tissues, or indirectly through contaminated surfaces and materials.
The incubation period for MVD ranges from 2 to 21 days, after which symptoms such as fever, chills, headache, muscle aches, severe malaise, and progressive weakness appear. Around the fifth day of illness, a maculopapular rash may occur, followed by diarrhea, nausea, vomiting, abdominal pain, and non-bloody stools. In some cases, patients may develop severe bleeding disorders, shock, liver failure, and multi-organ dysfunction, which can lead to death in 24-48 hours.
Currently, there are no approved vaccines or antiviral treatments for MVD, but supportive care is crucial for managing the symptoms of the disease. Preventive measures such as avoiding contact with infected individuals and their bodily fluids, wearing protective clothing, and practicing good hygiene can help prevent the spread of the virus.
Marburgvirus is a highly virulent species of filovirus, which is a genus of RNA viruses that can cause severe and often fatal hemorrhagic fever in humans and nonhuman primates, characterized by high fever, severe headache, muscle pain, chills, profound fatigue, and sometimes internal and external bleeding.
According to the World Health Organization (WHO), Marburgviruses are toxiviral hemorrhagic fever-causing agents that belong to the Filoviridae family, which also includes Ebolaviruses. These enveloped, non-segmented, negative-stranded RNA viruses cause a severe and often fatal illness in humans and non-human primates. The Marburg virus was initially discovered in 1967, after simultaneous outbreaks occurred in laboratories in Marburg and Frankfurt, Germany, and in Belgrade, Yugoslavia (now Serbia).
The virions of Marburgviruses are typically filamentous or U-shaped and measure approximately 80 nm in diameter. The genome consists of a single non-segmented, negative-sense RNA molecule that encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor protein (VP35), matrix protein (VP40), glycoprotein (GP), transcription activator protein (VP30), RNA-dependent RNA polymerase (L), and a small hydrophobic protein (sVP24 or VP80).
Marburgviruses are primarily transmitted to humans through contact with the bodily fluids of infected animals, such as bats and non-human primates. Human-to-human transmission can occur via direct contact with infected individuals' blood, secretions, organs, or other bodily fluids, as well as through contaminated surfaces and materials.
The incubation period for Marburg virus disease (MVD) typically ranges from 2 to 21 days. Initial symptoms include fever, chills, headache, muscle aches, and general malaise. As the disease progresses, patients may develop severe watery diarrhea, abdominal pain, nausea, vomiting, and unexplained bleeding or bruising. In fatal cases, MVD can cause multi-organ failure, shock, and death, often within 7 to 14 days after symptom onset.
Currently, there are no approved vaccines or antiviral treatments specifically for Marburg virus infections. However, supportive care, such as fluid replacement, electrolyte management, and treatment of secondary infections, can help improve outcomes for MVD patients. Preventive measures, including the use of personal protective equipment (PPE) and proper infection control practices, are crucial to reducing the risk of transmission during outbreaks.
"Encyclopedias, as a medical topic, refer to comprehensive and organized collections of information on various medical disciplines, theories, practices, diseases, treatments, and related health sciences, serving as extensive reference sources for medical professionals, students, researchers, and general public." (29 words)
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Hemorrhagic fevers, viral, are severe and often fatal diseases caused by various RNA viruses from the families Filoviridae (Ebola, Marburg), Arenaviridae (Lassa, Machupo, Junin, Guanarito, Sabia), Bunyaviridae (Hantavirus, Crimean-Congo) and Flaviviridae (Dengue, Kyasanur Forest, Omsk Hemorrhagic Fever viruses), characterized by fever, severe headache, muscle and joint pain, mucosal bleeding, and potentially fatal complications due to vascular leakage and multi-organ failure.
**Hemorrhagic fevers, viral** are a group of severe, potentially fatal illnesses caused by viruses that affect the body's ability to regulate its blood vessels and clotting abilities. These viruses belong to several different families including *Filoviridae* (e.g., Ebola, Marburg), *Arenaviridae* (e.g., Lassa, Machupo), *Bunyaviridae* (e.g., Hantavirus, Crimean-Congo hemorrhagic fever virus) and *Flaviviridae* (e.g., Dengue, Yellow Fever).
The initial symptoms are non-specific and include sudden onset of fever, fatigue, muscle aches, joint pains, headache, and vomiting. As the disease progresses, it may lead to capillary leakage, internal and external bleeding, and multi-organ failure resulting in shock and death in severe cases.
The transmission of these viruses can occur through various means depending on the specific virus. For example, some are transmitted via contact with infected animals or their urine/feces (e.g., Hantavirus), others through insect vectors like ticks (Crimean-Congo hemorrhagic fever) or mosquitoes (Dengue, Yellow Fever), and yet others through direct contact with infected body fluids (Ebola, Marburg).
There are no specific treatments for most viral hemorrhagic fevers. However, some experimental antiviral drugs have shown promise in treating certain types of the disease. Supportive care, such as maintaining blood pressure, replacing lost fluids and electrolytes, and managing pain, is critical to improving outcomes. Prevention measures include avoiding areas where the viruses are common, using personal protective equipment when caring for infected individuals or handling potentially contaminated materials, and controlling insect vectors.
Sources: Centers for Disease Control and Prevention (CDC), World Health Organization (WHO).
Lassa fever is an acute viral hemorrhagic fever caused by the Lassa virus, primarily transmitted through contact with infected Mastomys rodents or their excreta, and can also spread via human-to-human transmission through direct contact with infectious body fluids.
Lassa fever is an acute viral hemorrhagic fever caused by the Lassa virus. It is primarily transmitted to humans through contact with infected rodents or their excreta, and it can also spread from person to person via bodily fluids. The symptoms of Lassa fever typically include fever, sore throat, muscle pain, chest pain, headache, and vomiting. In severe cases, the disease can cause bleeding from the mouth and nose, as well as complications such as deafness and encephalitis. Lassa fever is endemic to West Africa, particularly in Nigeria, Guinea, Liberia, and Sierra Leone.
Hemorrhagic Fever, Ebola is a severe, often fatal illness in humans characterized by the sudden onset of fever, muscle pain, headache and sore throat, followed by vomiting, diarrhea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding.
Ebola Hemorrhagic Fever (EHF) is a severe, often fatal illness in humans. It is one of the five identified subtypes of the Ebolavirus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission.
The early symptoms include sudden onset of fever, fatigue, muscle pain, headache and sore throat. This is followed by vomiting, diarrhea, rash, symptoms of impaired kidney and liver function, and in some cases, both internal and external bleeding.
Laboratory findings include low white blood cell and platelet counts and elevated liver enzymes.
The virus is introduced into the human population through close contact with the blood, secretions, organs or other bodily fluids of infected animals such as fruit bats, porcupines and non-human primates. Then it spreads in communities through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials contaminated with these fluids.
Healthcare workers have frequently been infected while treating patients with suspected or confirmed EVD due to a lack of adequate infection prevention and control measures.
There are currently no approved specific antiviral drugs or vaccines for Ebola. Several promising treatments and vaccine candidates are being evaluated.
Junin virus is a species of the genus Arenavirus, causing Argentine hemorrhagic fever, primarily transmitted to humans through the contact with rodent excreta, mainly within endemic areas in Argentina.
Junin virus is a type of arenavirus that causes Argentine hemorrhagic fever, a severe and often fatal disease endemic to Argentina. The virus is primarily transmitted to humans through contact with the excreta of infected rodents, particularly the dryland vole (Microtus parvulus).
The Junin virus has a lipid envelope and a single-stranded RNA genome that encodes for four structural proteins and several nonstructural proteins. The viral glycoproteins are responsible for receptor binding, membrane fusion, and host immune response evasion.
Argentine hemorrhagic fever caused by Junin virus is characterized by fever, muscle pain, headache, and gastrointestinal symptoms, which can progress to severe bleeding, shock, and multi-organ failure in severe cases. The virus has a high case fatality rate if left untreated, but antiviral therapy with ribavirin and immune plasma from convalescent patients has significantly improved survival rates.
Prevention measures include avoiding contact with rodents, using personal protective equipment during high-risk activities, and implementing rodent control programs in endemic areas. Vaccination with the Candid #1 vaccine has also been shown to be effective in preventing Argentine hemorrhagic fever caused by Junin virus.
Remdesivir
"Methods for treating arenaviridae and coronaviridae virus infections", published 16 March 2017, issued 9 April 2019, assigned ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... The results found that remdesivir functioned well as an inhibitor of the infection. The study was published as a letter to the ... 19 infections. In January 2022, the FDA gave regulatory approval to remdesivir for use in adults and children (twelve years of ...
Coronaviridae
Other than for SARS-CoV-2, there are no vaccines or antiviral drugs to prevent or treat human coronavirus infections. They are ... Viruses portal Wikimedia Commons has media related to Coronaviridae. Wikispecies has information related to Coronaviridae. ... Coronaviridae is a family of enveloped, positive-strand RNA viruses which infect amphibians, birds, and mammals. The group ... The family Coronaviridae is organized in 2 sub-families, 5 genera, 26 sub-genera, and 46 species. Additional species are ...
Coronavirus
Myint SH (1995). "Human Coronavirus Infections". In Siddell SG (ed.). The Coronaviridae. The Viruses. Springer US. pp. 389-401 ... The earliest reports of a coronavirus infection in animals occurred in the late 1920s, when an acute respiratory infection of ... The infection of new-born chicks was characterized by gasping and listlessness with high mortality rates of 40-90%. Leland ... "2019 Novel Coronavirus infection (Wuhan, China): Outbreak update". Canada.ca. 2020-01-21. Hui DS, I Azhar E, Madani TA, Ntoumi ...
Project Gesundheit
Myint, Steven H. (1995). "Human Coronavirus Infections". In Siddell, Stuart G. (ed.). The Coronaviridae. The Viruses. Plenum ...
Torovirus
In all those infections, about 25% infections lead to sudden death. Besides other causes like diarrhea, pneumonia and ... The Coronaviridae. New York: Plenum Press, pp. 403-413 Weiss M, Steck F, Horzinek MC (September 1983). "Purification and ... Virus Infections of Ruminants. 3rd edn. Sweden: Elsevier Science, pp. 311-316 Bosch, A., Rosa M. Pintó, and Abad, Xavier. June ... Cattle, pig, and horse serve as the natural host of Toroviruses and infection is thought to be via the faecal-oral route. The ...
Ralph S. Baric
Infections. 9 (1): 505-507. doi:10.1080/22221751.2020.1733440. PMC 7054935. PMID 32102621. Coronaviridae Study Group of the ... "Human susceptibility and resistance to Norwalk virus infection". Nature Medicine. 9 (5): 548-553. doi:10.1038/nm860. PMID ...
List of MeSH codes (C02)
... coronaviridae infections MeSH C02.782.600.550.200 - coronavirus infections MeSH C02.782.600.550.200.325 - enteritis, ... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ...
RNA virus
Purified RNA of a positive-sense virus can directly cause infection though it may be less infectious than the whole virus ... Order Nidovirales Family Arteriviridae Family Coronaviridae - includes Human coronavirus (common cold viruses HCoV-229E, HCoV- ... Kondo H, Chiba S, Toyoda K, Suzuki N (January 2013). "Evidence for negative-strand RNA virus infection in fungi". Virology. 435 ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. Classification is based principally ...
Feline coronavirus
Infection of macrophages by FIPV is responsible for development of a fatal granulomatous vasculitis, or FIP (see granuloma). ... "ICTV 9th Report (2011) Coronaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 10 January 2019. ... Type I, that can be defined as 'FECV that could mutate to FIPV type I', is responsible for 80% of the infections. Typically, ... Feline coronavirus infections are therefore sialic acid dependent. The Porcine epidemic diarrhea virus (PEDV) S protein is 45% ...
Coronavirus diseases
In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses ... Biology portal Viruses portal Medicine portal Coronaviridae Alphacoronavirus Betacoronavirus Gammacoronavirus Deltacoronavirus ... Monto AS (1984). "Coronaviruses". In Evans AS (ed.). Viral Infections of Humans. pp. 151-165. doi:10.1007/978-1-4684-4727-9_7. ... Pappenheimer, Alwin M. (1 May 1958). "Pathology of Infection with the JHM Virus". JNCI: Journal of the National Cancer ...
Genetic variation
Recombination also occurs in the Coronaviridae ((+)ssRNA) (e.g. SARS). Recombination in RNA viruses appears to be an adaptation ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. Evolutionary biologists are often ... Bernstein H, Bernstein C, Michod RE (January 2018). "Sex in microbial pathogens". Infection, Genetics and Evolution. 57: 8-25. ...
RNA-based evolution
Recombination also occurs in the Coronaviridae ((+)ssRNA) (e.g. SARS). Recombination in RNA viruses appears to be an adaptation ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. RNA world Crick F (1970). "Central ... Bernstein H, Bernstein C, Michod RE (January 2018). "Sex in microbial pathogens". Infection, Genetics and Evolution. 57: 8-25. ...
Edward Thomas Ryan
D.M. Ojcius (ed.). "Microbes and Infection". Microbes and Infection. Elsevier. ISSN 1286-4579. OCLC 177511751. Edward Thomas ... assessment of immunologic cross-reactivity of SARS-CoV-2 with other coronaviridae, assessment of immune responses to SARS-CoV-2 ... Such treatment is usually contraindicated in humans infected with Shiga-toxin expressing E. coli infection (STEC/EHEC: ... Microbes and Infections, and is Senior Editor of Hunter's Tropical Infectious Diseases. Karlsson, Elinor K.; Harris, Jason B.; ...
Human coronavirus 229E
A NCBI-study found a previous HCoV-229E infection in 42.9% - 50.0% of children of 6-12 months of age and in 65% of those 2.5- ... Coronaviridae (Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, ... Esper, F.; Weibel, C.; Ferguson, D.; Landry, M. L.; Kahn, J. S. (2006). "Coronavirus HKU1 infection in the United States". ... Kaye, H. S.; Marsh, H. B.; Dowdle, W. R. (1971). "Seroepidemiologic survey of coronavirus (Strain OC 43) related infections in ...
Positive-strand RNA virus
After infection, the entirety of the host cell's translation machinery may be diverted to the production of viral proteins as a ... Recombination occurs in the Coronaviridae (e.g. SARS). Recombination in RNA viruses appears to be an adaptation for coping with ... Kolondam B, Rao P, Sztuba-Solinska J, Weber PH, Dzianott A, Johns MA, Bujarski JJ (2015). "Co-infection with two strains of ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans, as in the case of SARS and MERS. ...
Human coronavirus OC43
Both viruses can cause severe lower respiratory tract infections, including pneumonia, in infants, the elderly, and ... Virology online Coronaviruses Viralzone: Betacoronavirus Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae ( ... Infections show a seasonal pattern with most cases occurring in the winter months in temperate climates, and summer and spring ... the infection caused by the SARS-CoV-2 betacoronavirus) than to influenza. Brüssow, in August 2021, referred to the evidence ...
SARS-related coronavirus
"Direct cleavage of IRF3 by NSP3 could explain the blunted Type-I IFN response seen during SARS-CoV-2 infections while NSP5 ... Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (March 2020). "The species Severe acute ... PMID 32007145.{{cite journal}}: CS1 maint: multiple names: authors list (link) Coronaviridae Study Group of the International ... self-limiting infection that allows recombination events". Journal of Virology. 84 (6): 2808-19. doi:10.1128/JVI.02219-09. PMC ...
Nidovirales
The order includes the families Coronaviridae, Arteriviridae, Roniviridae, and Mesoniviridae. Member viruses have a viral ... co-terminal nested set of subgenomic mRNAs during infection. Nidoviruses have a viral envelope and a positive-sense, single- ... which included the Coronaviridae and Roniviridae (the large nidoviruses) and those with small genomes (the small nidoviruses)-a ... Abyssoviridae Arnidovirineae Arteriviridae Cremegaviridae Gresnaviridae Olifoviridae Cornidovirineae Coronaviridae ...
Transmissible gastroenteritis virus
The infection of cells with this altered virus elicits a specific lactogenic immune response against the heterologous protein. ... TGEV belongs to the family Coronaviridae, genus Alphacoronavirus, species Alphacoronavirus 1. It is an enveloped virus with a ... "ICTV 9th Report (2011) Coronaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 26 January 2019. ...
Viral disease
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... One family of enveloped viruses causes gastroenteritis (Coronaviridae). All other viruses associated with gastroenteritis are ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ... Page 273 in: Lennette's Laboratory Diagnosis of Viral Infections (Fourth ed.). CRC Press. 2010. ISBN 978-1420084962. Murillo A ...
Bovine coronavirus
Clinical signs may worsen with secondary bacteria infection. Infection in adults is normally subclinical, the exception being ... 2009). "ICTV 9th Report (2011) New Coronaviridae". International Committee on Taxonomy of Viruses (ICTV). Archived from the ... Infection causes calf enteritis and contributes to the enzootic pneumonia complex in calves. It can also cause winter dysentery ... Infection normally occurs in calves between the ages of one week and three months. Gastrointestinal signs include profuse ...
Murine coronavirus
The symptoms of infection vary according to the type, path of infection, genotype and age of mouse. MHV-1, MHV-S and MHV-Y are ... "Coronaviridae". Fenner's Veterinary Virology. Elsevier. 2017. pp. 435-461. doi:10.1016/b978-0-12-800946-8.00024-6. ISBN 978-0- ... Infection, even if it does not cause obvious symptoms, may affect the immune system of laboratory subjects and cause errors in ... Its infection depends on cleavage of the spike protein by endosomal enzymes. MHV-JHM (especially the more virulent JHM.SD and ...
Human pathogen
Helminthiasis (worm infection), Ascariasis, and enterobiasis (pinworm infection) are few that are caused by various parasitic ... Coronaviridae, Flaviviridae, Retroviridae, Orthomyxoviridae, Paramyxoviridae, Papovaviridae, Polyomavirus, Poxviridae, ... 2014). Immune Response to Parasitic Infections. Immune Response to Parasitic Infections. Vol. 2. Bentham Science Publishers. ... or yeast infections. Most antibiotics that function on bacterial pathogens cannot be used to treat fungal infections because ...
History of coronavirus
In October, in an attempt to identify the source of infection, it was found that the infection was acquired from the masked ... Coronaviridae Study Group of the International Committee on Taxonomy of Viruses) (2020). "The species Severe acute respiratory ... The bronchi infection resulted in severe gasping and swift death due to inability to eat food. It was also found that the ... The infection was believed to have been contained in China, but an infected individual carried it to Hong Kong on 21 February ...
Genetic recombination
Michod RE, Bernstein H, Nedelcu AM (May 2008). "Adaptive value of sex in microbial pathogens" (PDF). Infection, Genetics and ... and coronaviridae ((+)ssRNA) (e.g. SARS). Recombination in RNA viruses appears to be an adaptation for coping with genome ... Bernstein H, Bernstein C, Michod RE (January 2018). "Sex in microbial pathogens". Infection, Genetics and Evolution. 57: 8-25. ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. Especially in coronaviruses, ...
COVID-19 vaccine
February 2023). "Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis". The Lancet ... Previous projects to develop vaccines for viruses in the family Coronaviridae that affect humans have been aimed at severe ... The rapidly growing infection rate of COVID‑19 worldwide during 2020 stimulated international alliances and government efforts ... Lovelace Jr B (19 July 2022). "Nasal vaccines may stop Covid infections. Will we get them soon?". NBC News. Archived from the ...
Avian infectious bronchitis
The infection may prolong in the cecal tonsils.[citation needed] In laying hens, there can be transient respiratory signs, but ... The disease is caused by avian infectious bronchitis virus (IBV), a coronavirus (Coronaviridae, Orthocoronavirinae, genus ... However, for some strains, a kidney infection may follow, causing mortality by toxemia. Younger chickens may die of tracheal ... The most updated classification of IBV places the virus in Coronaviridae, Orthocoronavirinae, genus Gammacoronavirus, subgenus ...
Betacoronavirus
"Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels". Emerging Microbes & Infections. 8 (1): ... Coronaviruses Viralzone: Betacoronavirus Virus Pathogen Database and Analysis Resource (ViPR): Coronaviridae (Articles with ... coterminal nested set of subgenomic mRNAs during infection. Several structures of the spike proteins have been resolved. The ... The genus is in the subfamily Orthocoronavirinae in the family Coronaviridae, of the order Nidovirales. The betacoronaviruses ...
SARS-CoV-2
This means each infection from the virus is expected to result in 2.39 to 3.44 new infections when no members of the community ... Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (April 2020). "The species Severe acute ... The man's second infection was symptomatically more severe than the first infection, but the mechanisms that could account for ... and that subclinical infections may have been the source of a majority of infections. That may explain how out of 217 on board ...
List of Coronavirus live isolates
Infections. 7 (1): 154. doi:10.1038/s41426-018-0155-5. PMC 6135831. PMID 30209269. Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; ... Coronaviridae). ... human cells reveals potential susceptibility to infection". ... "Independent infections of porcine deltacoronavirus among Haitian children". Nature. 600 (7887): 133-137. Bibcode:2021Natur.600 ... "Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection". Journal of Virology. 94 (5): e01774-19. doi:10.1128/ ...
Advanced Search Results - Public Health Image Library(PHIL)
Multimedia | Portal Regional da BVS
Even if you are young and feeling well, an infection with COVID-19 could have long-lasting consequences on your health. See ... Coronavirus Infections/complications, Pneumonia, Viral/complications, Pandemics/prevention & control, Symptom Flare Up, Health ... Coronavirus Infections/complications, Pneumonia, Viral/complications, Pandemics/prevention & control, Symptom Flare Up, Health ... Coronavirus Infections/immunology, Pneumonia, Viral/immunology, Pandemics/prevention & control, Health Promotion, Risk Groups, ...
COVID-19 Variants: Coronavirus-2019 (COVID-19), Human Coronaviruses, 1965-Present, COVID-19 Variants and Subvariants
This was an infection with much greater morbidity and mortality than previous viruses from the Coronaviridae family. ... Most of these infections were from the BA.2.21.1 subvariant. The risk for long COVID from the new BA.4 and BA.5 subvariants is ... 6] Infections surged in December of that year. The Alpha variant soon surfaced around the world and became the dominant variant ... Beta infection also appeared to be less severe in individuals who had received the available COVID-19 vaccines or who had been ...
OLUMIANT Market Exclusivity Period (MEP). When do the OLUMIANT patents expire, and when will generic OLUMIANT be available?
Antiviral JAK inhibitors useful in treating or preventing coronaviridae infections. Patent Number: ⤷ Try a Trial. Patent ... Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections. ⤷ Try a Trial. ... Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections. Patent Number: ⤷ Try a ...
Remdesivir - Wikipedia
"Methods for treating arenaviridae and coronaviridae virus infections", published 16 March 2017, issued 9 April 2019, assigned ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... The results found that remdesivir functioned well as an inhibitor of the infection. The study was published as a letter to the ... 19 infections. In January 2022, the FDA gave regulatory approval to remdesivir for use in adults and children (twelve years of ...
The role of corticosteroids in the management of critically ill patients with coronavirus disease 2019 (COVID-19): A meta...
Studies must include viral infection belonging to the coronaviridae family only.. *ARDS included as the complication of ... Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Geneva: World ... To our knowledge this is the first meta-analysis of CS use in patients with coronavirus infections in general, and SARS-CoV-2 ... The pathogenic mechanism of infection and toxicity for SARS and SARS-CoV-2 is a result of an interplay between the viral ...
Severe Acute Respiratory Syndrome (SARS): Practice Essentials, Pathophysiology, Etiology
After establishment of infection, SARS-CoV causes tissue damage by (1) direct lytic effects on host cells and (2) indirect ... potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family. [38] This ... potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family, the SARS- ... After establishment of infection, SARS-CoV causes tissue damage by (1) direct lytic effects on host cells and (2) indirect ...
suPAR-guided Anakinra Treatment for Validation of the Risk and Management of Respiratory Failure by COVID-19 (SAVE) - Full Text...
Coronaviridae Infections. Nidovirales Infections. RNA Virus Infections. Lung Diseases. Respiratory Tract Diseases. Respiration ... Infections. Communicable Diseases. COVID-19. Virus Diseases. Respiratory Tract Infections. Coronavirus Infections. Respiratory ... COVID-19 Virus Diseases Corona Virus Infection Lower Respiratory Tract Infection Viral Drug: Anakinra Phase 2 ... Confirmed infection by SARS-CoV-2 virus using molecular techniques as defined by the World Health Organization ...
cultureinfo - Connecting Americans to Their Personal Health Care
DeCS
Infections à Coronaviridae Entry term(s):. Coronaviridae Infection. Infection, Coronaviridae. Infections, Coronaviridae. ... caused by members of the Coronaviridae family: do not confuse with CORONAVIRUS INFECTIONS caused by members of the Coronavirus ... Virus diseases caused by CORONAVIRIDAE. Preferred term. Coronaviridae Infections Entry term(s). Coronaviridae Infection ... Coronaviridae Infections - Preferred Concept UI. M0005199. Scope note. ...
Coronavirus -- THIS IS VIRUS
Diseases Virus Diseases RNA Virus Infections Nidovirales Infections Coronaviridae Infections Coronavirus Infections Organisms ... Coronaviridae. Coronavirus. Vertebrate Viruses. RNA Viruses. Nidovirales. Coronaviridae. Coronavirus. Copyright Restrictions: ... Viruses RNA Viruses Nidovirales Coronaviridae Coronavirus Vertebrate Viruses RNA Viruses Nidovirales Coronaviridae Coronavirus ...
![Consells per a una quarantena segura a lentorn educatiu [cartell]](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABAAAAAQCAMAAAAoLQ9TAAAAe1BMVEX///8AAHcAAHY+g+VCheZPjedFh+Z8p+zm7vs3gOX29vorW71Ch+giIIHIyNykwPJsnuumpcZZWJopJINZb7lglumuyPMWFH4AAHHK2/epxPI/PY62tdHg4OyEouGKsO5/fq9LSpMse+Ta1+U3MoisrMplZKBwb6dHRZH7Z08CAAAAn0lEQVQYlV1P1xLDMAgDY8dZbvZqRpvV9v+/sDhpkrvyACdxQgLgrEg52r0gxJ4k6W2Mn6Qmy4mKcpKa8a1CgXUQ6sa9k8NYYNv1/UDq0RRSgV/h0+rcSSpNXgQJjvvRcqKQYoARu5+NOwQ5D4P9YTzXyx8hLHFJYBUv7udRgEXY3WEL8EazTQ724WBri2LeNxzdljDzoeXnsixd/Q18AXynCMDEiSE3AAAAAElFTkSuQmCC)
Consells per a una quarantena segura a l'entorn educatiu [cartell]
RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Quarantena, : ... RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Quarantena, : ... infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], :Virus Diseases:: ... infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], :Virus Diseases:: ...
Nimotuzumab in COVID-19 | Registro Público Cubano de Ensayos ClÃnicos
Torovirus Infections | Palmetto Profiles
Nidovirales Infections [C02.782.600]. *Coronaviridae Infections [C02.782.600.550]. *Torovirus Infections [C02.782.600.550.800] ... "Torovirus Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Torovirus Infections" by people in this website by year, and ... Below are the most recent publications written about "Torovirus Infections" by people in Profiles. ...
Air Pollution, SARS-CoV-2 and the Wider Implications - An Overview of Recent Events with a Focus on Italy - Aerosol and Air...
... infections have spread worldwide. In part-I of our article, we show that the specificity of the speed of increase in COVID-19 ... Myint, S.H. (1995). Human Coronavirus Infections. in: Siddell, S.G. (Ed.), The Coronaviridae, Ch. 18. Springer (NY). https:// ... thus sudden rather than sigmoidal as in natural infections, and does not act at the site of the infection (nose, throat, lungs ... It also fuels existing concerns by which a low number of performed SARS-CoV-2 tests coupled with a low rate of infection can ...
European Journal of Internal Medicine - July 2020 | European Federation of Internal Medicine
Coronavirus, an enveloped virus belonging to the family of Coronaviridae which initially caused enzootic infections, has shown ... Predictors of infection after "de novo" cardiac electronic device implantation. 29 February 2020 ... Hepatic consequences of COVID-19 infection. Lapping or biting?. 1 June 2020 ... starting last December in China placed emphasis on liver involvement during infection. This review discusses the underlying ...
Frontiers | How Does COVID-19 Pandemic Impact on Incidence of Clostridioides difficile Infection and Exacerbation of Its...
Different symptoms developed by COVID-19 infection and its impacts on various organs of the human body have highlighted the ... The gastrointestinal (GI) tract is vulnerable to infection with COVID-19 and can be exploited as an alternative transmission ... The gastrointestinal (GI) tract is vulnerable to infection with COVID-19 and can be exploited as an alternative transmission ... Empiric antibiotic treatments for microbial infections in hospitalized patients with COVID-19 in addition to experimental ...
Medicinal Foods and Beverages Protect Against Coronavirus, Research
We must remember that immune status determines susceptibility to infection, and just like exposure does not equate to infection ... Clearly, the concept that deadly, invisible germs "out there" are out to get us, and that exposure equates infection equates ... Viral Infections: Herpes Simplex 1 and 2, Parainfluenza virus type 3, vaccinia virus, vesicular stomatitis virus and human ... "The common cold, known simply as a cold, is defined as an upper respiratory tract infection (URTI) caused by various viruses, ...
Strain Collections
Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)
Coronaviridae were considered as the etiological agent in 6-29% of respiratory infections (15,16), although the severity of the ... and severe pneumococcal infection in mice (133) resulting in shorter survival time after infection (134). Correspondingly, ... Golda A, Malek N, Dudek B, Zeglen S, Wojarski J, Ochman M, Kucewicz E, Zembala M, Potempa J and Pyrc K: Infection with human ... In turn, coronavirus infection was shown to impair mucociliary clearance (50) predisposing the lung for further viral and ...
DCs-based therapies: potential strategies in severe SARS-CoV-2 infection
The family Coronaviridae contains four genera called Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus [ ... Defects of DCs in CoV infection. CoV infection enables DCs to downregulate expression of MHC-I, MHC-II, and CD80/86 as well as ... Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection. Journal of ... Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN-alpha in a patient with newly ...
Suppression of the Cancer Treatment - Rife Machine Store
Phenotypes for Ifng MGI:6430488 MGI Mouse
increased susceptibility to Coronaviridae infection ( J:91691 ) • Background Sensitivity: viral titer of JHMV infected mice is ... increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:91691 ) • Background Sensitivity: mice ... increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:91691 ) • Background Sensitivity: mice ... Background Sensitivity: JHMV infected mice show massive liver necrosis at 5 days post infection (dpi) on a BALB/c background ...
Phenotypes for Ace2 MGI:5912243 MGI Mouse
Pesquisa | Portal Regional da BVS
CONCLUSION: Some members of the Coronaviridae family can cause highly contagious and devastating infections among humans. ... the circumstances of infection such as dose and route, current infection with other agents which includes the composition of ... infection of the eye is an example where damaging lesions are in part the consequence of a host response to the infection. ... Virus Infections and Host Metabolism-Can We Manage the Interactions? Sumbria, Deepak; Berber, Engin; Mathayan, Manikannan; ...
Epidemic Preparedness-Leishmania tarentolae as an Easy-to-Handle Tool to Produce Antigens for Viral Diagnosis: Application to...
This is the first application of an antigen produced in L. tarentolae for the serodiagnosis of a Coronaviridae infection. On ... This is the first application of an antigen produced in L. tarentolae for the serodiagnosis of a Coronaviridae infection. On ... and we recorded the ability of the purified RBD antigen to detect SARS-CoV-2 infection in human sera, with a sensitivity and ... and we recorded the ability of the purified RBD antigen to detect SARS-CoV-2 infection in human sera, with a sensitivity and ...
CDC Science Clips
We tested 12 additional virus families and found that SARS-CoV-2 of the Coronaviridae also required TMEM41B for infection. ... Hospitalized adults who had urinary, respiratory, skin and/or soft tissue, and intra-abdominal infections and were prescribed ... To identify host factors required for flavivirus infection, we performed full-genome loss of function CRISPR-Cas9 screens. ... The most common diagnoses were pneumonia (264 [33.0%]), upper respiratory tract infection and/or acute exacerbation of chronic ...
BetacoronavirusVirusesGenusTorovirus InfectionsFamilyZoonoticCoronaviruses2020Bacterial infectionsCoronavirus infection COVID-19EnfermedadesMorbidity and mortaSevereCovid-19 infectionHumansStrainsPneumoniaOutbreakRisk of bacterialVaccinesAcuteSymptomsClinicalChildren and adultsFurther investigationDiseases causedAntiviralHumanVirusPandemicRespiratory tractSuppressAsymptomaticLethalPrevention and treatmentImmuneLesionsFatalMolecularCommonControlPatients
Betacoronavirus1
- SARS-CoV-2 belongs to the family Coronaviridae and genus Betacoronavirus . (who.int)
Viruses10
- This was an infection with much greater morbidity and mortality than previous viruses from the Coronaviridae family. (medscape.com)
- Infections with viruses of the genus TOROVIRUS, family CORONAVIRIDAE. (musc.edu)
- Moreover, upper respiratory tract infections may be provoked by a wide range of viruses (as well as bacterial overgrowth). (greenmedinfo.com)
- Here, we used genome-scale CRISPR screens to identify Lysosomal Enzyme Trafficking factor (LYSET) as essential for infection by cathepsin-dependent viruses including SARS-CoV-2. (stanford.edu)
- Each of the 24 chapters of this volume present a brief account of major facets of HIV/AIDS research including epidemiology, HIV prevention, basic virology, clinical studies (including co-infection with mycobacteria and hepatitis viruses), antiretroviral therapy, treatment options for specific patient groups (such as pregnant women and elderly patients), patient psychology and public health concerns. (benthamscience.com)
- COVID-19 is the infection caused by SARS-CoV-2, a novel type of the previously well-known family of Corona Viridae viruses. (lyracore.com)
- These viruses are responsible for the majority of upper respiratory infections in humans. (lyracore.com)
- Coronaviridae (CoV) is a zoonotic family of positive-sense single-stranded RNA viruses that exhibit strong genetic diversity and pandemic potential. (peertechzpublications.com)
- We suggest introducing a system that can comprehensively monitor the regional prevalence of all viruses that cause acute respiratory infections. (who.int)
- coronavirus is part of a group of RNA viruses belonging to the Coronaviridae family, widely distributed in humans and other mammals. (bvsalud.org)
Genus1
- SARS-CoV-2 is a single-stranded, enveloped, and positive-sense RNA virus that belongs to the β-coronavirus genus, within the Coronaviridae family. (breathinglabs.com)
Torovirus Infections3
- Torovirus Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
- This graph shows the total number of publications written about "Torovirus Infections" by people in this website by year, and whether "Torovirus Infections" was a major or minor topic of these publications. (musc.edu)
- Below are the most recent publications written about "Torovirus Infections" by people in Profiles. (musc.edu)
Family7
- Therefore, because of the lack of Avian infectious bronchitis virus (IBV), a member of a vaccine against endemic strains of IBV in China, IBV family Coronaviridae, order Nidovirales, causes a infection has remained a problem in the Chinese poultry highly contagious respiratory and sometimes urogenital industry. (cdc.gov)
- Severe acute respiratory syndrome (SARS) is a serious, potentially life-threatening viral infection caused by a previously unrecognized virus from the Coronaviridae family, the SARS-associated coronavirus (SARS-CoV). (medscape.com)
- SARS-Related Coronavirus 2 is a wrapped, positive-sense singlestranded RNA infection from the Coronaviridae family and the Betacoronaviridae variety. (phrconference.org)
- SARS-Related Coronavirus 2 (Isolate: USAWA1/2020) is an encompassed, positive-sense singlestranded RNA infection from the Coronaviridae family and the Betacoronaviridae family. (entigen.com)
- Positive sense, single-stranded enveloped RNA virus belongs to the family Coronaviridae . (hopkinsguides.com)
- Coronavirus is a member of the Coronaviridae family. (bitrebels.com)
- Coronaviruses constitute the subfamily Orthocoronavirinae, in the family Coronaviridae, order Nidovirales, and realm Riboviria. (naijavibe.net)
Zoonotic3
- Toxoplasmosis in Animals Toxoplasmosis is an important zoonotic protozoal infection worldwide. (merckvetmanual.com)
- Lenshin S.V., Romashin A.V., Vyshemirsky O.I., Lvov D.K., Alkhovsky S.V. Bats of the subtropical climate zone of the Krasnodar Territory of Russia as a possible reservoir of zoonotic viral infections. (crie.ru)
- SARS-CoV-2 uncertainty exists regarding whether its emergence into human populations appears to be a zoonotic infection or related to release from a laboratory studying the virus. (hopkinsguides.com)
Coronaviruses4
- Human coronaviruses (HCoVs) first were identified in 1965 as a common cause of mild upper and lower respiratory infections in children and adults, similar to illness produced by rhinoviruses and respiratory syncytial virus. (medscape.com)
- We previously developed a pan-coronavirus fusion inhibitor, EK1, which targeted the HR1 domain and could inhibit infection by divergent human coronaviruses tested, including SARS-CoV and MERS-CoV. (nature.com)
- EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested, including SARS-CoV and MERS-CoV, as well as SARSr-CoVs, and potently inhibited the replication of 5 live human coronaviruses examined, including SARS-CoV-2. (nature.com)
- In humans, coronaviruses cause respiratory tract infections that can be mild, such as some cases of the common cold (among other possible causes, predominantly rhinoviruses), and others that can be lethal, such as SARS, MERS, and COVID-19. (naijavibe.net)
20202
- Preliminary unpublished data from 57 Greek patients hospitalized after March 1st, 2020 in Greek hospitals due to pneumonia by confirmed SARS-CoV-2 infection showed that those with suPAR admission levels ≥ 6 ng/ml had greater risk for the development of SRF within 14 days than patients with suPAR less than 6ng/ml. (clinicaltrials.gov)
- This infection was segregated from a patient with a respiratory ailment who had gotten back from movement to the impacted area of China and created COVID-19 in January 2020 in Washington, USA. (entigen.com)
Bacterial infections3
- In addition to lung involvement, common symptoms observed in COVID-19 and CDI such as diarrhea, highlight the significance of bacterial infections in COVID-19 patients. (frontiersin.org)
- As you can see, all these symptoms are generally nonspecific and can be associated with other viral and bacterial infections as well as other non-infectious ailments and maladies and a wide range of true psychiatric disorders in any human being. (lyracore.com)
- They are crucial in protecting the respiratory tract against viral and bacterial infections. (breathinglabs.com)
Coronavirus infection COVID-191
- Pashkov E.A., Korchevaya E.R., Faizuloev E.B., Svitich O.A., Pashkov E.P., Nechaev D.N., Zverev V.V. Potential of application of the RNA interference phenomenon in the treatment of new coronavirus infection COVID-19. (crie.ru)
Enfermedades1
- Enfermedades vÃricas causadas por CORONAVIRIDAE. (bvsalud.org)
Morbidity and morta1
- The critical role of the immune system has been found in the discovery that there are reported high morbidity and mortality rates of human CoV infection in immunocompromised host as well as patients with comorbidities [ 3 - 6 ]. (medsci.org)
Severe13
- The YN isolate caused severe continuous determination of the epidemic serotype and lesions and resulted in deaths of 65% in experimental production of new generations of vaccines are crucial for infections of 30-day-old specifi c-pathogen-free chickens. (cdc.gov)
- Studies highlighting the use of CS in coronavirus infection with severe acute respiratory syndrome (SARS), Middle East Respiratory Syndrome (MERS) and COVID-19 were selected based on pre-determined inclusion criteria. (fortunejournals.com)
- World map of severe acute respiratory syndrome (SARS) distribution from the 2002-2003 outbreak infection. (medscape.com)
- In the SAVE study patients with lower respiratory tract infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at high risk for progression to serious respiratory failure will be detected using the suPAR biomarker. (clinicaltrials.gov)
- Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by the newly identified beta-coronavirus known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ( 1 , 2 ). (frontiersin.org)
- Han J, Sun J, Zhang G, Chen H. DCs-based therapies: potential strategies in severe SARS-CoV-2 infection. (medsci.org)
- We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
- Thus, it is urgent to develop therapeutic strategies to face the SARS-CoV-2 viral infection at the severe stage. (medsci.org)
- Corticosteroids are associated to an increased risk of COVID-19 infection, higher hospitalization rate and higher risk of severe COVID-19. (elsevier.es)
- Severe infections remain more prevalent in the unimmunized or no prior infection with multiple risk factors and people with poor antibody responses to vaccines or infections. (hopkinsguides.com)
- 65 yrs, and people with comorbidities appear more likely to develop an infection with severe symptoms and be at risk for death. (hopkinsguides.com)
- The term coronavirus (CoV) is itself derived from the Latin word 'corona' meaning 'crown' and they cause a wide range of mild to severe respiratory tract infections. (curescience.org)
- Anesthesiologists are on the frontline in the war against the global COVID-19 pandemic, providing airway, ventilatory, and hemodynamic support to acute patients suffering from severe and critical COVID-19 infection. (peertechzpublications.com)
Covid-19 infection2
- Different symptoms developed by COVID-19 infection and its impacts on various organs of the human body have highlighted the importance of both coinfections and superinfections with other pathogens. (frontiersin.org)
- This has raised the question of possible higher incidence and severity of COVID-19 infection in IBD patients. (elsevier.es)
Humans1
- Herpes simplex virus infection is a major cause of vision loss in humans. (bvsalud.org)
Strains3
- Outbreaks of IB often isolated from 30-day-old broiler chickens that exhibited are due to infections with strains serologically different respiratory symptoms, nephropathologic lesions, and a from those used for vaccination ( 2 , 6 ). (cdc.gov)
- EMMA strains that could be used for Coronaviridae infection research. (infrafrontier.eu)
- Strains are related to SARS-CoV-2 and other Coronaviridae viral infections via their human orthologues. (infrafrontier.eu)
Pneumonia1
- Pneumonia caused by the SARS-CoV-2 is spreading continuously, the ability to adapt host and genomic mutation of Coronavirus (CoV) lead to hampering in treatment or control of the infection. (medsci.org)
Outbreak3
- Since the outbreak of coronavirus disease 2019 (COVID-19) associated with the novel SARS-CoV-2, infections have spread worldwide. (aaqr.org)
- Both WHO's Global Outbreak Alert and Response Network and Global Influenza Network were on high alert after reports from Hong Kong, on 19 and 20 February, confirming two cases (one fatal) of infection with avian influenza virus A, subtype H5N1. (who.int)
- The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. (nature.com)
Risk of bacterial2
- Improved Zn status may also reduce the risk of bacterial co‑infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. (spandidos-publications.com)
- IBD treatments have been associated to an increased risk of bacterial and viral infections. (elsevier.es)
Vaccines2
- Zainutdinov S.S., Sivolobova G.F., Loktev V.B., Kochneva G.V. Mucosal immunity and vaccines against viral infections. (crie.ru)
- There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections. (naijavibe.net)
Acute1
- As inadequately treated acute infections can be rapidly fatal and enrolment into a trial must often be undertaken empirically before culture results are known, it is obviously desirable that the control arm be predicted to be efficacious in all studies, including studies of potentially superior new agents. (gardp.org)
Symptoms5
- How Does COVID-19 Pandemic Impact on Incidence of Clostridioides difficile Infection and Exacerbation of Its Gastrointestinal Symptoms? (frontiersin.org)
- As a general precaution against further nosocomial transmission, WHO recommended that patients with similar symptoms should be isolated and managed according to strict procedures of infection control. (who.int)
- 2012 ). To rule out the possibility that a potential association between lithium and respiratory infection rate is secondary to the effect on psychiatric symptoms, we also calculated the association between valproate medication and respiratory infections. (springeropen.com)
- While some patients decompensate within a week, a large subset of patients remain asymptomatic throughout the course of infection (Table 1) [12] Children, in particular, are more likely to have few or no symptoms yet remain infectious carriers [13,14]. (peertechzpublications.com)
- In Japan, during the initial period of the COVID-19 respiratory viral infections significantly decreased during pandemic, the clinical priority for patients with respiratory the COVID-19 pandemic, although the infections did symptoms or fever was to test for SARS-CoV-2 to ensure not completely disappear. (who.int)
Clinical1
- In this Antimicrobial Viewpoint article, I explore the two types of clinical trials: Superiority and non-inferiority (NI) as well as the lethal danger of Infections and how antibiotics are best developed before we need them. (gardp.org)
Children and adults1
- Earlier data demonstrate that populational Zn status is associated with the prevalence of respiratory tract infections in children and adults ( 6 , 7 ). (spandidos-publications.com)
Further investigation1
- The relevance of the adenovirus co-infection remains unclear and merits further investigation. (biomedcentral.com)
Diseases caused1
- Virus diseases caused by CORONAVIRIDAE. (bvsalud.org)
Antiviral4
- Empiric antibiotic treatments for microbial infections in hospitalized patients with COVID-19 in addition to experimental antiviral and immunomodulatory drugs may increase the risk of antibiotic-associated diarrhea (AAD) and Clostridioides difficile infection (CDI). (frontiersin.org)
- The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents. (nih.gov)
- Garbuzenko D.V. The role of antiviral therapy in the management of patients with liver cirrhosis associated with chronic HBV and HCV infection. (crie.ru)
- This study provides real-world evidence that lithium is associated with decreased risk for respiratory infections and suggests that the repurposing potential of lithium for potential antiviral or antibacterial effects is worthy of investigation. (springeropen.com)
Human7
- The successful development and implementation to intervene prevention and treatment of virus infection over the past hundred years have had great advances on human and animal health. (medsci.org)
- We engineered L. tarentolae to express the SARS-CoV-2 receptor-binding domain (RBD) and we recorded the ability of the purified RBD antigen to detect SARS-CoV-2 infection in human sera, with a sensitivity and reproducibility comparable to that of a reference antigen produced in human cells. (unipv.it)
- GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. (mdpi.com)
- The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. (stanford.edu)
- Coronavirus for common human respiratory coronavirus infections. (hopkinsguides.com)
- Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy presents comprehensive and updated information on drug therapies used to treat and manage HIV infection in human patients. (benthamscience.com)
- It was concluded that during SARS-CoV-2 infection of human respiratory Calu-3 cells the MUC1 extracellular domain prevents the binding of the virus to the underlying receptor. (breathinglabs.com)
Virus12
- Vea este video para saber cómo tener en cuenta la distancia a otras personas y la ubicación y duración de las actividades en las zonas de transmisión generalizada del virus de la COVID-19. (bvsalud.org)
- Remdesivir was originally developed to treat hepatitis C, and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID‑19. (wikipedia.org)
- The gastrointestinal (GI) tract is vulnerable to infection with COVID-19 and can be exploited as an alternative transmission route and target for virus entry and pathogenesis. (frontiersin.org)
- The immune system could play a crucial role in virus infection. (medsci.org)
- The attempts to treat virus infections occur even earlier than there was an understanding of the concept of a virus as an independent entity. (medsci.org)
- However, to this day, in the fight against virus infection, there is no real winner. (medsci.org)
- We make the point that in several viral infections the lesions can be largely the result of one or more aspects of the host response mediating the cell and tissue damage rather than the virus itself being directly responsible. (bvsalud.org)
- Herpes simplex virus (HSV) infection of the eye can result in a blinding immunoinflammatory lesion in the cornea called herpetic stromal keratitis (HSK). (bvsalud.org)
- MERS for the MERS-CoV virus, causing sporadic infections, mainly in the Arabian peninsula since 2012. (hopkinsguides.com)
- Small studies in the 1990s suggested reduced rates of herpes virus infections with lithium (Amsterdam et al. (springeropen.com)
- In this blog series, Dr. Furman will help explain what this virus is, what it does, what are the known complications of the infection, recent evidence and research-based available treatments, as well as discussions of differences of immediate effects of the virus versus "early-late" complications and late complications of the viral infection, as well as possible roads to recovery. (lyracore.com)
- No significant increase in SARS-CoV-2 infection was observed in live virus experiments after neuraminidase or fucosidase treatment. (breathinglabs.com)
Pandemic1
- The Chinese Society of Anesthesiology reports a 20% cross-infection rate among anesthesiologists who performed intubations on COVID-19 patients during the early phase of the pandemic [1]. (peertechzpublications.com)
Respiratory tract2
- Most of these have involved serious respiratory tract infections. (naijavibe.net)
- Therefore, little is known about pathogens personal protective measures - such as wearing masks, other than SARS-CoV-2 that caused respiratory tract encouraging handwashing and avoiding crowds and infections during this period. (who.int)
Suppress1
- We have also discussed potential therapeutic targets to diminish the viral infection and suppress the inflammatory response, with respect to evidenced studies based on COVID-19 research. (bvsalud.org)
Asymptomatic1
- Infection is generally asymptomatic and chronic in immunocompetent individuals. (merckvetmanual.com)
Lethal1
- Rabies infection (RABV), logical name Rabies lyssavirus, is a lethal neurotropic infection that causes rabies in people and creatures. (entigen.com)
Prevention and treatment1
- Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection, suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. (nature.com)
Immune3
- In this review, we discuss a variety of immune modulating approaches that could be used to counteract tissue-damaging viral immunoinflammatory lesions which typify many chronic viral infections. (bvsalud.org)
- Porcine innate and adaptative immune responses to influenza and coronavirus infections. (nih.gov)
- Further, Dr. Fauci ignores that 30% or so of the US population have recovered from and are immune to SARS-CoV-2 infection, thus reducing the need for vaccine induced immunity to something like 45% in order to reach a herd immunity threshold. (realclearmarkets.com)
Lesions1
- We emphasize examples where such therapies are, or could be, translated for practical use in the clinic to control inflammatory lesions caused by viral infections. (bvsalud.org)
Fatal1
- Infections move quickly and can be fatal! (gardp.org)
Molecular1
- To develop specific anti-coronavirus therapeutics and prophylactics, the molecular mechanism that underlies viral infection must first be defined. (nature.com)
Common1
- Investigators believe that this may be due to exposure to other so-called "common cold" coronaviridae. (realclearmarkets.com)
Control3
- With simple control measures, this viral infection was eradicated. (medscape.com)
- This review details these unique viral features and reviews the evidence base regarding infection prevention and control (IPC) in the anesthesia workspace. (peertechzpublications.com)
- If local control measures can reduce the spread of the target infection (good for the community! (gardp.org)
Patients4
- The rate ratio (RR) for mortality in patients with SARSCoV-2 infection was 1.26 (95% CI: 0.96-1.65, I2: 74.46), indicating lack of benefit of CS therapy on mortality in critically ill patients with COVID-19. (fortunejournals.com)
- The RR for mortality on analysis of the three studies that particularly reported on patients with significant pulmonary compromise secondary to SARS-CoV-2 infection was neutral (RR: 0.91, 95% CI: 0.63- 1.33, I2: 63.38). (fortunejournals.com)
- Here, the aim was to investigate the association between lithium use and the risk of respiratory infections in patients with bipolar disorder. (springeropen.com)
- 2017 ). Here, we leveraged a Swedish cohort of more than 50,000 patients with bipolar disorder followed over eight years to investigate if lithium treatment is associated with risk of respiratory infections. (springeropen.com)
