'Deoxy sugars' are monosaccharides or oligosaccharides that contain fewer hydroxyl groups than the corresponding hexose or pentose, with deoxyribose being a well-known example of a deoxy sugar.

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. (1/352)

Macrophages incubated in 2-deoxy-D-glucose (2-dG)-containing medium showed a marked decrease in cellular ATP content, and were unable to ingest IgG- and complement-coated erythrocytes via the corresponding membrane receptors for these ligands. However, the inhibitory effects of 2-dG on Fc- and C3 receptor-mediated phagocytosis were not a consequence of lowered macrophage ATP levels since addition of glucose or mannose to the culture medium restored the capacity of the macrophages to ingest IgG- and C3-coated particles without increasing ATP levels. These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin dependent) differs qualitatively from the ingestion of latex and zymosan particles (opsonin independent); they suggest that the same regulatory molecules govern the responses of phagocytic cells to signals initiated by both the Fc and C3 receptors. The possibility that these molecules are regulated by glycosylation is discussed.  (+info)

Structure of the O-specific polysaccharide of a serologically separate strain Proteus penneri 2 from a new proposed serogroup O66. (2/352)

O-specific polysaccharide chain of Proteus penneri strain 2 lipopolysaccharide was studied by full and partial acid hydrolysis, Smith degradation, methylation analysis, and NMR spectroscopy, including two-dimensional rotating-frame NOE spectroscopy (ROESY) and 1H,13C heteronuclear multiple-quantum coherence (HMQC) experiments. Together with D-glucose and 2-acetamido-2-deoxy-D-glucose, the polysaccharide was found to contain two rarely occurring sugars, 6-deoxy-L-talose (L-6dTal) and 2,3-diacetamido-2,3,6-trideoxy-L-mannose (L-RhaNAc3NAc), and the following structure of a non-stoichiometrically O-acetylated tetrasaccharide repeating unit was established: [equation: see text] The O-specific polysaccharide studied has a unique composition and structure and, accordingly, P. penneri 2 is serologically separate among Proteus strains. Therefore, we propose for P. penneri 2 a new Proteus O-serogroup O66 where this strain is at present the single representative.  (+info)

Interactions on 3-deoxy and 6-deoxy derivatives of N-acetyl-D-glucosamine with hen lysozyme. (3/352)

The interactions of deoxy derivatives of GlcNAc, 6-deoxy-GlcNAc, and 3-deoxy-GlcNAc with hen egg-white lysozyme [EC 3.2.1.17] were studied at various pH's by measuring the changes in the circular dichroic (CD) band at 295 nm. It was shown that 6-deoxy-GlcNAc and 3-deoxy-GlcNAc bind at subsite C of lysozyme and compete with GlcNAc. The pH dependence of the binding constant of 6-deoxy-GlcNAc was the same as that of GlcNAc. On the other hand, the binding constants of 3-deoxy-GlcNAc were 3--10 times smaller than those of GlcNAc in the pH range from 3 to 9. X-ray crystallographic studies show that O(6) and O(3) of GlcNAc at subsite C are hydrogen-bonded to the indole NH's of Trp 62 and Trp 63, respectively, but the above results indicate that Trp 63, not Trp 62, is important for the interaction of GlcNAc with lysozyme.  (+info)

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect. (4/352)

Incubation of normal or thioglycollate-elicited mouse peritoneal macrophages with 2-deoxy-D-glucose (2-dG) inhibits the capacity of these macrophages to phagocytize IgG- or complement-coated particles via their Fc and C3 receptors. 2-dG has no inhibitory effect on the capacity of these macrophages to phagocytize latex or zymosan particles, which are ingested in the absence of specific opsonins, and it does not inhibit binding of IgG- or C3-coated particles to their respective receptors on the macrophage's plasma membrane. 2-dG exerts its inhibitory effect on the macrophage and not on the opsonized particle. The inhibition is independent of particle size, occurs within 15-30 min of addition of this glucose analogue to the medium at 37 degrees C, cannot be overcome by supra-agglutinating amounts of opsonizing antibody, and is completely reversible by substitution of 5.5 mM glucose for 50 mM 2-dG in the medium. Addition of equimolar amounts of glucose or mannose, but not of fructose, galactose, fucose, or glucosamine, to medium containing 50 mM 2-dG results in substantial reversal of the inhibitory effect of 2-dG on Fc and C3 receptor mediated phagocytosis.  (+info)

Interference of nucleoside diphosphate derivatives of 2-deoxy-D-glucose with the glycosylation of virus-specific glycoproteins in vivo. (5/352)

The predominant effect of 2-deoxy-D-glucose on chick embryo cells infected with Semliki Forest virus is an interference with glycosylation of virus-specific glycoproteins; this results in a block of synthesis of infectious virus. Incorporation of radioactive mannose is blocked severely in the presence of 2-deoxyglucose in the cultural medium although it is readily phosphorylated and subsequently activated by GTP to yield GDP-mannose, which accumulates under these conditions. The intracellular concentrations of GDP-mannose and UDP-N-acetyl-D-hexosamine are not reduced in the presence of the inhibitor. An equimolar concentration of mannose in the cultural medium competes with the inhibitory effect of the deoxysugar and drops the cellular pool of GDP-2-deoxy-D-glucose below the level of detection, at the same time restoring the synthesis of infectious virus. When the intracellular concentration of UDP-2-deoxyglucose is reduced by addition of glucose into the cultural medium the inhibition of virus synthesis by the deoxysugar and the concentration of GDP-2-deoxyglucose within the cells remain near to the values when the inhibitor is present alone. It is concluded that among the metabolites of 2-deoxyglucose which occur in vivo after addition of 2-deoxyglucose to the culture medium, GDP-2-deoxyglucose is the agent responsible for inhibition of glycosylation of viral glycoproteins.  (+info)

[18F]-labeled 3-deoxy-3-fluoro-D-glucose: synthesis and preliminary biodistribution data. (6/352)

A cyclotron target system for the production of anhydrous [18F] fluoride ion has been developed and used for the synthesis of carrier-free [18F]-3-deoxy-3fluoro-D-glucose (3-FDG). The synthesis is sufficiently rapid and efficient to allow production of usable amounts of 3-FDG with a 6-MeV cyclotron. Preliminary animal studies show that 3-FDG is in fact a glucose analog.  (+info)

The effect of 2-deoxy-D-glucose and D-glucose on the efferent discharge rate of sympathetic nerves. (7/352)

Efferent discharges were recorded from nerve filaments dissected from the adrenal and renal nerves in the rabbit. 2. An increase in discharge rate was observed in the adrenal nerve filaments following I.V. administration of 2-deoxy-D-glucose (2-DG). No change in discharge rate after 2-DG infusion was observed in the renal nerve filaments. 3. A decrease in discharge rate of the adrenal nerve filaments was observed after I.V. injection of glucose, but there was no change in the activity of renal nerve filaments. 4. Transection of the spinal cord abolished the adrenal nerve response to the systemic administration of 2-DG and glucose. 5. It is suggested that there might be a pathway from the hypothalmic area to the adrenal nerve cells of the spinal cord, but not to the renal nerve cells, through which activity of the adrenal nerve might be changed in response to 2-DG and glucose infusion.  (+info)

Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. (8/352)

The serotype c-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans NCTC 9710 contains an unusual sugar, 6-deoxy-L-talose, which has been identified as a constituent of cell wall components in some bacteria. Two genes coding for thymidine diphosphate (dTDP)-6-deoxy-L-lyxo-4-hexulose reductases were identified in the gene cluster required for biosynthesis of serotype c-specific polysaccharide. Both dTDP-6-deoxy-L-lyxo-4-hexulose reductases were overproduced and purified from Escherichia coli transformed with the plasmids containing these genes. The sugar nucleotides converted by both reductases were purified by reversed-phase high performance liquid chromatography and identified by (1)H nuclear magnetic resonance and gas-liquid chromatography. The results indicated that one of two reductases produced dTDP-6-deoxy-L-talose and the other produced dTDP-L-rhamnose (dTDP-6-deoxy-L-mannose). The amino acid sequence of the dTDP-6-deoxy-L-lyxo-4-hexulose reductase forming dTDP-6-deoxy-L-talose shared only weak homology with that forming dTDP-L-rhamnose, despite the fact that these two enzymes catalyze the reduction of the same substrate and the products are determined by the stereospecificity of the reductase activity. Neither the gene for dTDP-6-deoxy-L-talose biosynthesis nor its corresponding protein product has been found in other bacteria; this biosynthetic pathway is identified here for the first time.  (+info)

Deoxy sugars, also known as deoxyriboses, are sugars that have one or more hydroxyl (-OH) groups replaced by a hydrogen atom. The most well-known deoxy sugar is deoxyribose, which is a component of DNA (deoxyribonucleic acid).

Deoxyribose is a pentose sugar, meaning it has five carbon atoms, and it differs from the related sugar ribose by having a hydrogen atom instead of a hydroxyl group at the 2' position. This structural difference affects the ability of DNA to form double-stranded helices through hydrogen bonding between complementary base pairs, which is critical for the storage and replication of genetic information.

Other deoxy sugars may also be important in biology, such as L-deoxyribose, a component of certain antibiotics, and various deoxyhexoses, which are found in some natural products and bacterial polysaccharides.

Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. Examples include: Deoxyribose, or 2-deoxy ... Deoxy+Sugars at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview at qmul.ac.uk (Articles with ... Deoxynucleotide "Deoxy sugars". Nature Publishing Group. Retrieved 22 May 2016. Sable, Henry Z.; Wright, Elmer M.; Bagatell, ... the same precursor as ribose being that the reduction of the sugar with the extra hydroxyl group results in the deoxy-sugar, ...
Wang SF, Gabriel O (1969). "Biological mechanisms involved in the formation of deoxy sugars. V Isolation and crystallization of ... This enzyme participates in 4 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, polyketide sugar ... The systematic name of this enzyme class is dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming). Other ... dTDP-4-dehydro-6-deoxy-D-glucose + H2O The first protein structures of a dTDP-glucose 4,6-dehydratase (RmlB) were completed by ...
Gaugler RW, Gabriel O (1973). "Biological mechanisms involved in the formation of deoxy sugars VII. Biosynthesis of 6-deoxy-L- ... This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar ... dTDP-4-dehydro-6-deoxy-L-mannose Hence, this enzyme has one substrate, dTDP-4-dehydro-6-deoxy-D-glucose, and one product, dTDP- ... The systematic name of this enzyme class is dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase. Other names in common use include ...
Gaugler RW, Gabriel O (1973). "Biological mechanisms involved in the formation of deoxy sugars VII. Biosynthesis of 6-deoxy-L- ... TDP-6-deoxy-L-talose dehydrogenase, thymidine diphospho-6-deoxy-L-talose dehydrogenase, and dTDP-6-deoxy-L-talose dehydrogenase ... the two substrates of this enzyme are dTDP-6-deoxy-L-talose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L- ... In enzymology, a dTDP-6-deoxy-L-talose 4-dehydrogenase (EC 1.1.1.134) is an enzyme that catalyzes the chemical reaction dTDP-6- ...
... (Rha, Rham) is a naturally occurring deoxy sugar. It can be classified as either a methyl-pentose or a 6-deoxy-hexose ... Rhamnose predominantly occurs in nature in its L-form as L-rhamnose (6-deoxy-L-mannose). This is unusual, since most of the ... Brown, M. R. (1991). "The amino-acid and sugar composition of 16 species of microalgae used in mariculture". Journal of ... Rhamnose is commonly bound to other sugars in nature. It is a common glycone component of glycosides from many plants. Rhamnose ...
... or 6-deoxy-tagatose is a ketohexose deoxy sugar. Fuculose is involved in the process of sugar metabolism. l-Fuculose ... Deoxy sugars, Ketohexoses, All stub articles, Biochemistry stubs). ...
... is a glycoside formed from the flavonoid quercetin and the deoxy sugar rhamnose. Austrian chemist Heinrich Hlasiwetz ...
Three-carbon deoxysugars are also precursor to the 1,2-diol. A small-scale, nonbiological route from D-mannitol is illustrated ... Propylene glycol is an approved food additive for dog and sugar glider food under the category of animal feed and is generally ... Propylene glycol occurs naturally, probably as the result of anaerobic catabolism of sugars in the human gut. It is degraded by ...
... thereby making it a deoxy sugar) and the L-configuration. It is equivalent to 6-deoxy-l-galactose. In the fucose-containing ... Fucose is a hexose deoxy sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian, insect and ... Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the ... Roca, C (2015). "Exopolysaccharides enriched in rare sugars: bacterial sources, production, and applications". Front Microbiol ...
... producing dTDP-4-keto-6-deoxy-glucose. Xue M. He & Hung-wen Liu (2002). "Formation of unusual sugars: Mechanistic studies and ... It is the starting compound for the syntheses of many deoxysugars. DTDP-glucose is produced by the enzyme glucose-1-phosphate ... DTDP-glucose goes on to form a variety of compounds in nucleotide sugars metabolism. Many bacteria utilize dTDP-glucose to form ... During the syntheses of many of these exotic sugars, dTDP-glucose undergoes a combined oxidation/reduction reaction via the ...
Deoxy sugar Rodríguez E, Peirú S, Carney JR, Gramajo H (March 2006). "In vivo characterization of the dTDP-D-desosamine pathway ... Desosamine in the US National Library of Medicine MeSH (Medical Subject Headings): Deoxy Sugar in the US National Library of ... Degradation of several of the aforementioned antibiotics yields the desosamine sugar. It is found in combination with the ... Alkaline degradation found the sugar to be a D-hexose derivative. Glycosidic cleavage of methomycin produces aglycone ...
... is a deoxy sugar and amino sugar of the hexosamine class. Daunosamine is a component of the anthracycline class of ...
... is a deoxy sugar that is a component of various cardiac glycosides including thevetin and emicymarin. It was first ... Sarmentose, a related deoxy sugar Digitalose, Merck Index, 12th Edition, 3202 Kiliani (1892). "Ueber Digitalonsäure". Chem. Ber ...
Degens, E; Bajor, M (1963). "Amino acids and sugars in the bruderheim and Murray meteorite". Die Naturwissenschaften. 49 (24): ... Nuevo, M; Cooper, G; Sandford, S (2018). "Deoxyribose and deoxysugar derivatives from photoprocessed astrophysical ice ... sugars and amino acids existed in space, via meteorites. This includes non-terrestrial amino acids. Multiple isotopes do not ...
With triethylsilane (R'=H), the reaction yields a 2,3-unsaturated deoxy sugar. An analogous reaction with nitrogen as the ... Donohoe, Timothy J.; Blades, Kevin; Helliwell, Madeleine (1999). "Synthesis of amino-sugars using the directed dihydroxylation ...
"Cyclopropenium Cation Promoted Dehydrative Glycosylations Using 2-Deoxy- and 2,6-Dideoxy-Sugar Donors". Journal of the American ... This method of mildly generating acid chlorides can also be useful for linking alpha-anomeric sugars. After using the ... This iodine can thereafter be substituted by any ROH group to quickly undergo alpha-selective linkage of sugars. Additionally, ...
At Harvard he worked with R. B. Woodward on deoxy sugars and a synthesis of the alkaloid yohimbine. Lemal began his independent ...
4) 2-Deoxysugars are unable to form the cyclic cation intermediate 1 because of their missing benzoyl group; instead, under ... 11) The sugar derivatives used for SHJ reactions should be purified, dried, and powdered before use. Intramolecular Friedel- ... 6) in the presence of a protected sugar chloride provides the nucleoside in 59% yield. Reactions of this type are hampered by ... 7) Transglycosylation, which involves the reversible transfer of a sugar moiety from one heterocyclic base to another, is ...
... is a hexose deoxy sugar that in several antibiotics (such as erythromycin) is attached to the macrolide ring. In ... Deoxy sugars, Monosaccharides, All stub articles, Organic compound stubs). ...
A well-studied example is sugar metabolism via the keto-deoxy-phosphogluconate pathway (also called ED pathway) in Pseudomonas ... Moreover, there is a third alternative sugar-catabolic pathway used by some bacteria, the pentose phosphate pathway. The ... for sugar metabolism and the citric acid cycle to degrade acetate, producing energy in the form of ATP and reducing power in ...
"Environmental and Intestinal Phylum Firmicutes Bacteria Metabolize the Plant Sugar Sulfoquinovose via a 6-Deoxy-6-sulfofructose ... Sulfoglycolysis is a catabolic process in primary metabolism in which sulfoquinovose (6-deoxy-6-sulfonato-glucose) is ... in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12". Microbiology. ...
Its name indicates that it is a deoxy sugar, meaning that it is derived from the sugar ribose by loss of a hydroxy group. ... Since the pentose sugars arabinose and ribose only differ by the stereochemistry at C2′, 2-deoxyribose and 2-deoxyarabinose are ...
v t e (Orphaned articles from May 2015, All orphaned articles, All stub articles, Pharmacology stubs, Amino sugars, Deoxy ... The Maillard reaction of sugars and amines results in the formation of glycosylamines and Amadori products that are of ...
Third-generation Glycoazodyes are synthesized using amino sugars such as 6-amino-6-deoxy-D-galactose or 6' amino-6'- ... Either the dye or the sugar is reacted with succinic anhydride. This forms an amide group with the sugar or an ester group with ... or lactose sugar group. The point of the ether bond is controlled by selectively protecting alcohol groups on the sugar, or by ... An ether group bonds the sugar and the dye to an n-alkane spacer, and the spacer bonds to the dye through another ether group. ...
... , also known as 6-sulfoquinovose and 6-deoxy-6-sulfo-D-glucopyranose, is a monosaccharide sugar that is found as ... the sulfonic acid group is introduced into the sugar by the enzyme UDP-sulfoquinovose synthase (SQD1). Sulfoquinovose is ...
... s are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, ...
Deoxy sugars, Aldohexoses). ... versus Radiolabeled Sugars by Rumen Bacteria and Escherichia ...
Deoxy sugars, Aldohexoses). ... 2-Deoxy-d-glucose is a glucose molecule which has the 2- ... On May 8, 2021, the Drugs Controller General of India approved an oral formulation of 2-deoxy-D-glucose for emergency use as ... In clinical medical imaging (PET scanning), fluorodeoxyglucose is used, where one of the 2-hydrogens of 2-deoxy-D-glucose is ... 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked ...
Deoxy sugars, Methoxy compounds). ... it is a dideoxy sugar. The hydroxyl group at C3 is methylated. ... Sarmentose, a diastereomeric dideoxy sugar Siddiqui, Bina Shaheen; Khatoon, Nasima; Begum, Sabira; Farooq, Ahsana Dar; Qamar, ...
Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. Examples include: Deoxyribose, or 2-deoxy ... Deoxy+Sugars at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview at qmul.ac.uk (Articles with ... Deoxynucleotide "Deoxy sugars". Nature Publishing Group. Retrieved 22 May 2016. Sable, Henry Z.; Wright, Elmer M.; Bagatell, ... the same precursor as ribose being that the reduction of the sugar with the extra hydroxyl group results in the deoxy-sugar, ...
Käännös haulle deoxy sugar englannista suomeksi. Suomienglantisanakirja.fi on suomen ja englannin kääntämiseen keskittyvä ... deoxy sugar (suomeksi). Määritelmät:. *(lb, en, chemistry) Any compound formally derived from a sugar by replacing a hydroxy ... Viimeisimmät haut: deoxy sugar, Fabergé egg, gave it some welly, biomanufacture, Faber, industriousness ...
Mitchell, Helen Buss (2006). Sweeteners and Sugar Alternatives in Food Technology. Wiley-Blackwell. ISBN 978-1-4051-3434-7. .. ...
Find quality suppliers and manufacturers of 2-Deoxy-D-ribosefor price inquiry.where to buy 2-Deoxy-D-ribose.Also offer free ... database of 2-Deoxy-D-ribose including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density ... 2H Sugars; Riboses and 2-Deoxyriboses; Biochemistry; Deoxysugars; Nucleosides, Nucleotides & Related Reagents; Ribose; Sugars ... 2-deoxy-;2-Deoxy-beta-D-erythro-pentose;2-deoxy-d-ribose/thyminose;Deoxy-Ribose;2-Deoxy-D-arabinose;D-erythro-Pentose; ...
Scientists at the University of Tübingen in Germany have discovered a sugar molecule that inhibits plants and microorganisms ... Deoxy sugar - a natural herbicide that is harmless for humans and animals. The rare deoxy sugar was isolated from cultures of ... "Unlike with glyphosate, the newly discovered deoxy-sugar is an entirely natural product. We expect 7dSh to show good ... The sugar blocks an enzyme of the so-called shikimate pathway, a metabolism route that only occurs in microorganisms and plants ...
Deoxy sugars. C01019 L-Fucose. BRITE hierarchy. Other DBs. CAS: 2438-80-4. ...
SUGAR (1-DEOXY-D-XYLULOSE-5-PHOSPHATE); SN-GLYCEROL-3-PHOSPHATE. Polypeptides. Pyridoxine 5-Phosphate Synthase. Oligo-state. ... SUGAR (1-DEOXY-D-XYLULOSE-5-PHOSPHATE); SN-GLYCEROL-3-PHOSPHATE. Polypeptides. Pyridoxine 5-Phosphate Synthase. Oligo-state. ... SUGAR (1-DEOXY-D-XYLULOSE-5-PHOSPHATE); SN-GLYCEROL-3-PHOSPHATE. Polypeptides. Pyridoxine 5-Phosphate Synthase. Oligo-state. ... SUGAR (1-DEOXY-D-XYLULOSE-5-PHOSPHATE); SN-GLYCEROL-3-PHOSPHATE. Polypeptides. Pyridoxine 5-Phosphate Synthase. Oligo-state. ...
... the sugar component of DNA - and several deoxysugar derivatives in residues produced from the ultraviolet irradiation of ice ... "The presence of sugar derivatives in primitive meteorites, together with other compounds of biological interest such as amino ... Laboratory experiments have shown that a sugar critical to the structure of DNA arises when ice formed on planets, asteroids ... The work continues about 25 years of experimentation regarding the formation of sugars as a result of non-biological ...
Fürstner, A.; Weidmann, H. Highly selective metal-graphite-induced reductions of deoxy halo sugars. The Journal of Organic ... Fragmentation of 0-Alkylidene-Deoxy Halo Sugars. Journal of Carbohydrate Chemistry 1990, 9, 561-570. ... Csuk, R.; Fürstner, A.; Glänzer, B. I.; Weidmann, H. A new, zinc-promoted synthesis of 1,4-(1,5)-anhydro-2-deoxy-pent-(hex)-1- ... Fragmentations of 1-deoxy-1-iodo-2,3;4,5-di-O-isopropylidene pentitols. Tetrahedron Letters 1990, 31, 3735-3738. ...
Macrolides are compounds that contain lactone rings with attached deoxy sugars. These macrolides have antifungal or antibiotic ...
... and Preparation of Quaternary 2-Deoxy 2-Acetamido Sugars. *. Kévin. Mébarki. ... In these processes, a tricoordinate boronic ester initially serves as a protective group for a sugar-derived 1,2- or 1,3-diol ... we report herein the robust and scalable conversion of sugar γ-lactones into highly valuable glycosides having a quaternary ...
Nashalian, O., Yaylayan V. In Situ formation of the amino sugars 1-amino-1-deoxy-fructose and 2-amino-2-deoxy-glucose under ... Nashalian, O., Yaylayan V. In Situ formation of the amino sugars 1-amino-1-deoxy-fructose and 2-amino-2-deoxy-glucose under ...
A nucleotide is made up of a pentose sugar called deoxy ribose, a nitrogenous base and a phosphate group.. Each molecule of ... A nucleotide is made up of a pentose sugar called deoxy ribose, a nitrogenous base and a phosphate group.. Each molecule of ...
In 1983 a study on Microcystis aeruginosa LPS suggested a structure rich in Kdo, 3-deoxy sugars, glucosamine, hexoses, ... Neutral sugars such as glucose, rhamnose, mannose and galactose are always present, while peculiar sugars are occasionally ... Rhamnose is the most abundant sugar in this LPS (more than 75%) and the O-antigen structure proposed is a long chain of α-1,3- ... Lipid A is linked to the proximal moiety of the oligosaccharidic core at position C6, where it binds covalently a 3-deoxy-D- ...
... it has been shown using light diffraction studies in human red blood cells that several sugars, including 2-deoxy-D-glucose, D- ... The daunosamine sugar moiety is important for doxorubicin activity because 7-deoxydoxorubicionolone lacking the sugar has been ... 2-Deoxy-D-glucose (FDG) is used in imaging and locating tumor metastases [29]. Concomitantly, 2-deoxy-D-glucose is used as an ... 2-Deoxy-D-glucose (2-DG). 2-DG is a glucose analog in which the C-2 hydroxyl group is replaced with hydrogen. 2-DG competes ...
PDB Description: The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin ...
Chemical Clockwise Tridifferentiation of α- and β-Cyclodextrins: Bascule-Bridge or Deoxy-Sugars Strategies,. Olivia Bistri, ...
Every single nucleotide will consist of one five-carbon pentose sugar - ribose in RNA, and deoxy-ribose in DNA; One flat, ... DNA is made of monomers formed by the pentose sugar deoxy-ribose, along with a nitrogenous base and inorganic phosphate to make ... the RNA monomers by the absence of an oxygen at the number two carbon in the sugars and are called a 2-deoxy-β-D-ribose sugars. ... RNA is made from monomers of the sugar β-D-ribose and the sugar along with the nitrogenous base and inorganic phosphate is ...
... and reducing sugars. To circumvent this, we modified our hydrolysis conditions to promote sugar-sugar cleavage. With this ... However, a novel class of polysaccharides characterized by high N-acetyl aminosugar and 6-deoxysugar content, escapes rapid ... Acid hydrolysis of DOM polysaccharides releases a suite of characteristic neutral sugars (glucose, galactose, mannose, rhamnose ...
Deoxysugars are ubiquitous in nature where they function in a variety of biological processes, including cell adhesion, immune ... CDP-D-Glucose is the precursor for synthesizing four of the five naturally occurring 3,6-dideoxy sugars-abequose (3,6-dideoxy-D ...
... and 14 sugar molecules (10 2-acetamido-2-deoxy-beta-D-glycopyranose molecules and 4 beta-D-mannopyranose molecules). The final ... Densities corresponding to sugar moieties were observed on residues N98, N415, N444, N504, N1469, N1529, N1588, and N1662. It ... The final model, consisting of 1941 residues, 14 lipids, 1 detergent molecule, and 14 sugar molecules, was refined to excellent ... and 14 sugar molecules. Structural model validation was done using Phenix and MolProbity (Chen et al., 2010). The local ...
Enzymes Deoxy sugars. 30 Isolation and characterization of a novel thermostable and catalytically efficient laccase from ... The feeding of purified sugar diets containing two different levels of each of the three sugars, sucrose, maltose and lactose, ... Biochemical studies of the enzymes involved in deoxysugar D-forosamine biosynthesis. Hong, Lin, Liu, Hung-wen, January 2004 ( ...
Unique sugars in LPS include the core sugar, KDO (3 deoxy-α-D-manno-octulosonic acid), and unique arrangements of sugars in the ... The unique LPS structure and associated sugar residues and arrangement are outlined in Figure 2. The enzymatic cascade used to ...
3-Fluoro-3-deoxy-D-galactose: A new probe for studies on sugar cataract. Secchi, E. F., Lizak, M. J., Sato, S. & Kador, P. F., ... 3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis. Farzin, A., Miri, A. K., Sharifi, F., Faramarzi, N., Jaberi, A ...
Deoxy-ribose sugar ... Lactase breaks down lactose sugar Enzymes • Folded specific to ... SIMPLE CARBOHYDRATES They are the main source of energy for the body ! Simple sugars Monosaccharide Glucose, for example (Yes ... Active Site Specific Enzyme Starch ***** Remember That Enzymes are substrate-specific !!!!! Simple useable sugars (product) ... blood sugar), either because insulin production is inadequate, or because the bodys cells do not respond properly to insulin, ...
4.1.2 Deoxy sugars 122. 4.1.3 Amino sugars 122. 4.1.4 Sugar alcohols 125. 4.1.5 Acidic sugars 125. 4.2 Polysaccharides 127. 4.3 ... 4.5 Sugar antibiotics 134. 4.6 Cyclitols 138. References 142. 5 Amino Acids, Peptides, and Proteins 145. 5.1 Amino acids 145. ... 4 Sugars 115. 4.1 Monosaccharides 116. 4.1.1 Aldoses and ketoses 116. ...
The deoxy-sugar l-fucose is also a key potential building block for many antiviral drugs and in the production of Human Milk ... The new deoxysugars will ultimately be available as part of the Companys zuCarb™ rare sugar catalog and will also be used ... For example, some deoxy-sugars are natural components of the most commercially successful antibiotics and are key in their ... "The technology we are developing will allow dozens of new deoxy-sugars to be made available to researchers exploring the ...
Why not a pentose? Or a tetrose? Or a deoxy sugar? Or just some other hexose, like fructose? Is there some chemical reason life ...
  • Deoxyribose is derived from the same precursor as ribose being that the reduction of the sugar with the extra hydroxyl group results in the deoxy-sugar, which has its hydroxyl group replaced with a hydrogen atom. (wikipedia.org)
  • The CAS register number of 2-Deoxy-D-ribose is 533-67-5. (lookchem.com)
  • Uses of 2-Deoxy-D-ribose: it can be used to produce lithium 2-deoxy-D-erythro-pentonate at temperature of 40 °C. This reaction will need reagent 3 M KOH, 30 percent H 2 O 2 , MgO, 0.1 M LiOH with reaction time of 18 hours. (lookchem.com)
  • The result produced a variety of simple sugars - including ribose, a key component of RNA. (cosmosmagazine.com)
  • RNA is made from monomers of the sugar β-D-ribose and the sugar along with the nitrogenous base and inorganic phosphate is called a ribonucleotide - without the phosphate, it's a nucleoside. (herbs2000.com)
  • DNA is made of monomers formed by the pentose sugar deoxy-ribose, along with a nitrogenous base and inorganic phosphate to make a deoxyribonucleotide. (herbs2000.com)
  • The DNA monomers are differentiated from the RNA monomers by the absence of an oxygen at the number two carbon in the sugars and are called a 2-deoxy-β-D-ribose sugars. (herbs2000.com)
  • Horton Derek, Kokrady Satish S.: Acyclic-sugar nucleoside analogs derived from cytosine with the d-aldopentoses, and from uracil with d-lyxose and d-ribose. (iupac.org)
  • The sugar in DNA has 5 carbon atoms (labelled 1′ - 5′), and is called deoxy-ribose (hence the "Deoxy-ribo" in DNA). (tourwimberleytx.com)
  • The deoxy prefix indicates that the 2′ carbon atom of the sugar lacks the oxygen atom that is linked to the 2′ carbon atom of ribose (the sugar in ribonucleic acid, or RNA), as shown in Figure 5.2. (tourwimberleytx.com)
  • The pentose sugar in DNA is called deoxyribose, and in RNA, the sugar is ribose. (tourwimberleytx.com)
  • The difference between the sugars is the presence of the hydroxyl group on the 2′ carbon of the ribose and its absence on the 2′ carbon of the deoxyribose. (tourwimberleytx.com)
  • Deoxy sugars are sugars that have had a hydroxyl group replaced with a hydrogen atom. (wikipedia.org)
  • Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. (reference.md)
  • Definition Glycosides are non-reducing organic compounds that on hydrolysis with acids or enzymes yield: 1- A sugar part (or glycone, formed of one or more sugar units). (slideshare.net)
  • These constitute the non-sugar moieties of the glycosides  Types acc. (slideshare.net)
  • to glycosidic linkage: They contain free -OH group (in O-glycosides), free NH (in N-glycosides), free SH(in S- glycosides)  The common linkage between the sugar part and the aglycone is an oxygen linkage connecting the reducing group of a sugar and an alcoholic or a phenolic hydroxyl group of the aglycone to give O-glycosides. (slideshare.net)
  • to the stereo of the sugars: sugars exist in isomeric - and -forms, both - and -glycosides are theoretically possible, but most of the naturally occurring glycosides are of the -type  Types acc. (slideshare.net)
  • Glycosides Dr. Mostafa Hegazy The sugar moiety in glycosides consists of either : 1- A monosaccharide molecule (e.g. glucose, rhamnose. (slideshare.net)
  • Common sugar in glycosides is -D-glucose, Other sugars (like pentoses and deoxy-hexoses) Sugar derivatives (e.g. uronic acids such as glucuronic acid in glycyrrhizin) are also found. (slideshare.net)
  • Glycosides Dr. Mostafa Hegazy Sugar Attachment The sugar moiety is attached to the aglycone part mostly at : one position (e.g. in monodesmosidic saponins), or two different positions (e.g. in bidesmosidic saponins). (slideshare.net)
  • In a paper published in the journal Nature Communications , Michel Nuevo, George Cooper, and Scott Sandford, all from NASA's Ames Research Centre in the US, report detecting 2-deoxyribose - the sugar component of DNA - and several deoxysugar derivatives in residues produced from the ultraviolet irradiation of ice mixtures under standard astrophysical conditions in the laboratory. (cosmosmagazine.com)
  • The presence of sugar derivatives in primitive meteorites, together with other compounds of biological interest such as amino acids, nucleobases, and amphiphiles is consistent with a scenario in which a significant fraction of the inventory of compounds from which biological processes started on the primitive Earth may have been delivered via comets, meteorites, and interplanetary dust particles (IDPs)," the authors write. (cosmosmagazine.com)
  • Blieszner Kathleen C., Horton Derek, Markovs Robert A.: Acyclic-sugar purine nucleosides derived from d-glucose: stereochemical correlations in acyclic-sugar derivatives unequally substituted at c-1. (iupac.org)
  • Baker David C., Horton Derek: Synthesis and stereochemical characterization of a series of five-carbon, acyclic-sugar derivatives of 1,6-dihydro-6-thioxopurine (6-mercaptopurine). (iupac.org)
  • Horton Derek, Liu Charng-Ming: Microbial oxidation as a route for cyclization of acylic-sugar nucleosides. (iupac.org)
  • Acid hydrolysis of DOM polysaccharides releases a suite of characteristic neutral sugars (glucose, galactose, mannose, rhamnose, fucose and xylose), but most of the polysaccharide (80-90%) resists hydrolysis and undergoes Maillard-like reactions between amino- and reducing sugars. (copernicus.org)
  • The addition of the phosphate group also covalently connected to the sugar unit completes the basic component of the nucleic acid polymer. (herbs2000.com)
  • These components of the nucleic acids are linked together covalently through a glycosidic bond formed between the sugar unit and the nitrogenous base. (herbs2000.com)
  • Unique sugars in LPS include the core sugar, KDO (3 deoxy-α-D-manno-octulosonic acid), and unique arrangements of sugars in the O-antigen moiety, which are used to distinguish bacterial strains when characterising various gram-negative bacteria foodborne illness outbreaks (serotyping). (europeanpharmaceuticalreview.com)
  • containing less oxygen in the molecule than the compound from which it is derived deoxy sugars -usually used in combination deoxyribonucleic acid. (tourwimberleytx.com)
  • The sugar present in the DNA is 2'deoxyribose, a five carbon monosaccharide, which is devoid of oxygen in its 2′ position, hence the name deoxyribonucleic acid. (tourwimberleytx.com)
  • The sugar in deoxyribonucleic acid (DNA) is deoxyribose. (tourwimberleytx.com)
  • However, a novel class of polysaccharides characterized by high N-acetyl aminosugar and 6-deoxysugar content, escapes rapid degradation and accumulates as a constituent of marine dissolved organic matter (DOM). (copernicus.org)
  • CDP-D-Glucose is the precursor for synthesizing four of the five naturally occurring 3,6-dideoxy sugars-abequose (3,6-dideoxy-D-Xylo-hexose), ascarylose (3,6-dideoxy-L-arabino-hexose), paratose (3,6-dideoxy-D-ribohexose), and tyvelose (3,6-dideoxy-D-arabino-hexose. (nih.gov)
  • They are the amino sugar part and the hexose ring in the center, which can be 2-deoxystreptamine or streptidine. (pharmacygyan.com)
  • In this antibiotic contains two or more amino sugars joined in glycoside linkage and a centrally located substituted 1,3-diaminocyclo hexane (aminocyclitol) loop. (pharmacygyan.com)
  • Two amino sugars are bound to strepidine in streptomycine . (pharmacygyan.com)
  • Two amino sugars are bound to 2-deoxy strepamine in the kanamycin and gentamycin families. (pharmacygyan.com)
  • Amino sugars are bound to 2-deoxy streptamine in the neomycin family. (pharmacygyan.com)
  • Some biologically important dideoxy sugars, sugars that have had two hydroxyl groups replaced with hydrogen atoms, include colitose and abequose. (wikipedia.org)
  • The sugar blocks an enzyme of the so-called shikimate pathway, a metabolism route that only occurs in microorganisms and plants. (rural21.com)
  • The rare deoxy sugar was isolated from cultures of the freshwater cyano-bacterium Synechococcus elongatus , which is capable of inhibiting the growth of related bacteria strains. (rural21.com)
  • has been identified as the 2nd most consensus (ERIC) sequences which · 60 environmental samples were tak- frequent organism causing ventilator- are common to Gram-negative enteric en throughout the ICU, including associated pneumonia, the 4th most bacteria [11,12]. (who.int)
  • Deoxy-ATP (dATP) can reach toxic levels that inhibit ribonucleotide reductase, an enzyme essential for synthesis of DNA precursors. (medscape.com)
  • Weidmann, H. A new, zinc-promoted synthesis of 1,4-(1,5)-anhydro-2-deoxy-pent-(hex)-1-enitols (furanoid and pyranoid glycals). (mpg.de)
  • Horton Derek, Sakata Masakatsu: Synthesis of purine and pyrimidine 2′-deoxynucleosides from a 1,2-dithio sugar precursor. (iupac.org)
  • To circumvent this, we modified our hydrolysis conditions to promote sugar-sugar cleavage. (copernicus.org)
  • After hydrolysis the sugar part has reducing characters. (slideshare.net)
  • deoxyribose, also called d-2-deoxyribose, five-carbon sugar component of DNA (q.v. (tourwimberleytx.com)
  • Laboratory experiments have shown that a sugar critical to the structure of DNA arises when ice formed on planets, asteroids and meteorites is subjected to ultraviolet radiation. (cosmosmagazine.com)
  • Scientists at the University of Tübingen in Germany have discovered a sugar molecule that inhibits plants and microorganisms and is harmless to human cells. (rural21.com)
  • The newly discovered sugar molecule originating from cyanobacteria inhibits the growth of various microorganisms and plants, but is harmless to humans and animals. (rural21.com)
  • The Tübingen research team consisting of chemists and microbiologists have now hit upon a very unusual antimetabolite with an incredibly simple chemical structure: a sugar molecule going by the scientific name of "7-desoxy-Sedoheptulose" (7dSh). (rural21.com)
  • Deoxysugars are ubiquitous in nature where they function in a variety of biological processes, including cell adhesion, immune response, determination of ABO blood groups, fertilization, antibiotic function, and microbial pathogenicity. (nih.gov)
  • It also can be called as 2-Deoxy-D-erythropentose and the IUPAC name about this chemical is 3,4,5-trihydroxypentanal. (lookchem.com)
  • The oligosaccharidic core consists of 10 - 12 sugars divided in a proximal and a distal region. (scirp.org)
  • The work continues about 25 years of experimentation regarding the formation of sugars as a result of non-biological astrophysical processes. (cosmosmagazine.com)
  • They also tested samples from selected meteorites and detected the presence of deoxysugars. (cosmosmagazine.com)
  • En Égypte, les isolats des patients étaient de types ERIC VII, VIII et IX et correspondaient à ceux des tubulures des appareils d'aspiration et de respiration artificielle et des cuvettes. (who.int)
  • Bell R.Hays, Horton Derek, Williams Diana M., Winter-Mihaly Eva: Photochemical conversion of sugar dimethylthio-carbamates into deoxy sugars. (iupac.org)
  • Weidmann, H. Highly selective metal-graphite-induced reductions of deoxy halo sugars. (mpg.de)
  • Because the cross-links occurred between sulphur-rich parts of the mucin protein, the team developed a sulphur-containing anti-oxidant sugar called TDG (methyl 6-thio-6-deoxy-alpha-D-galactopyranoside) to reverse the effect. (thenakedscientists.com)
  • In these processes, a tricoordinate boronic ester initially serves as a protective group for a sugar-derived 1,2- or 1,3-diol motif, permitting functionalization of free OH groups. (acs.org)