A rare, aggressive soft tissue sarcoma that primarily affects adolescents and young adults. It is most commonly found in the abdomen.
Abdominal neoplasms refer to abnormal growths or tumors occurring within the abdominal cavity, which can be benign or malignant, and affect various organs such as the pancreas, liver, kidneys, or intestines.
A sarcoma characterized by the presence of small cells, cells measuring 9-14 micrometers with a faint or indistinct rim of cytoplasm and an oval-to-elongated nucleus with relatively dense chromatin. (From Segen, Dictionary of Modern Medicine, 1992)
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
A ubiquitous hnRNP protein found in the CELL NUCLEUS and the CYTOPLASM. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS may play a role in neoplastic processes such as EWING SARCOMA.
A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
A form of RHABDOMYOSARCOMA arising primarily in the head and neck, especially the orbit, of children below the age of 10. The cells are smaller than those of other rhabdomyosarcomas and are of two basic cell types: spindle cells and round cells. This cancer is highly sensitive to chemotherapy and has a high cure rate with multi-modality therapy. (From Holland et al., Cancer Medicine, 3d ed, p2188)
Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.
A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Tumors or cancer of the PERITONEUM.
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A form of RHABDOMYOSARCOMA occurring mainly in adolescents and young adults, affecting muscles of the extremities, trunk, orbital region, etc. It is extremely malignant, metastasizing widely at an early stage. Few cures have been achieved and the prognosis is poor. "Alveolar" refers to its microscopic appearance simulating the cells of the respiratory alveolus. (Holland et al., Cancer Medicine, 3d ed, p2188)
A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with EWING SARCOMA.
A extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)
A liposarcoma containing myxomatous tissue. (Dorland, 27th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer located in bone tissue or specific BONES.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
A solid tumor consisting of a dense infiltration of MAST CELLS. It is generally benign.
Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Desmoplastic small round cell tumour in a 74 year old man: an uncommon cause of ascites (case report). (1/12)

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Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. (2/12)

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Imaging of desmoplastic small round cell tumour in adults. (3/12)

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Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. (4/12)

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Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors. (5/12)

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Clinical outcomes of patients with desmoplastic small round cell tumor of the peritoneum undergoing autologous HCT: a CIBMTR retrospective analysis. (6/12)

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Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. (7/12)

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Mediastinal mass-a rare presentation of desmoplastic small round cell tumour. (8/12)

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A Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive type of cancer that primarily affects young adults, typically between the ages of 10 to 30. It is characterized by the presence of small round tumor cells that are surrounded by a dense fibrous or desmoplastic stroma.

DSRCTs usually originate in the abdominal cavity, particularly in the peritoneum, which is the membrane that lines the abdominal wall and covers the organs within it. However, they can also occur in other parts of the body such as the lungs, mediastinum, and pelvis.

The tumor cells in DSRCTs typically have a specific chromosomal abnormality known as the t(11;22)(p13;q12) translocation, which results in the fusion of two genes - EWSR1 and WT1. This genetic alteration is thought to contribute to the development and progression of DSRCTs.

DSRCTs are highly aggressive tumors that tend to spread rapidly throughout the body, making them difficult to treat. Treatment options typically include a combination of surgery, chemotherapy, and radiation therapy, although the prognosis for patients with DSRCTs is generally poor, with a five-year survival rate of less than 15%.

Abdominal neoplasms refer to abnormal growths or tumors in the abdomen that can be benign (non-cancerous) or malignant (cancerous). These growths can occur in any of the organs within the abdominal cavity, including the stomach, small intestine, large intestine, liver, pancreas, spleen, and kidneys.

Abdominal neoplasms can cause various symptoms depending on their size, location, and type. Some common symptoms include abdominal pain or discomfort, bloating, changes in bowel habits, unexplained weight loss, fatigue, and fever. In some cases, abdominal neoplasms may not cause any symptoms until they have grown quite large or spread to other parts of the body.

The diagnosis of abdominal neoplasms typically involves a combination of physical exam, medical history, imaging studies such as CT scans or MRIs, and sometimes biopsy to confirm the type of tumor. Treatment options depend on the type, stage, and location of the neoplasm but may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches.

Small cell sarcoma is a very rare and aggressive type of cancer that affects the connective tissues in the body, such as muscles, tendons, bones, cartilage, and fat. It is called "small cell" because the cancer cells are small and appear round or oval in shape, with scant cytoplasm and finely granular chromatin.

Small cell sarcoma typically occurs in adults between the ages of 40 and 70, and it can develop in any part of the body. However, it is most commonly found in the extremities, trunk, and retroperitoneum. The exact cause of small cell sarcoma is not known, but it is thought to be associated with genetic mutations that occur during a person's lifetime.

Small cell sarcoma can be difficult to diagnose because it often does not cause any symptoms until it has advanced to an aggressive stage. When symptoms do occur, they may include pain, swelling, or a lump in the affected area. Diagnosis typically involves a biopsy of the tumor tissue, followed by imaging tests such as CT scans, MRI scans, or PET scans to determine the extent of the cancer.

Treatment for small cell sarcoma usually involves surgery to remove the tumor, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells. However, because small cell sarcoma is so rare and aggressive, treatment options may be limited, and the prognosis is often poor. Clinical trials of new treatments are also an option for some patients.

Ewing sarcoma is a type of cancer that originates in bones or the soft tissues surrounding them, such as muscles and tendons. It primarily affects children and adolescents, although it can occur in adults as well. The disease is characterized by small, round tumor cells that typically grow quickly and are prone to metastasize (spread) to other parts of the body, most commonly the lungs, bones, and bone marrow.

Ewing sarcoma is caused by a genetic abnormality, specifically a chromosomal translocation that results in the fusion of two genes, EWSR1 and FLI1. This gene fusion leads to the formation of an abnormal protein that disrupts normal cell growth and division processes, ultimately resulting in cancer.

Symptoms of Ewing sarcoma can vary depending on the location and size of the tumor but may include pain or swelling in the affected area, fever, fatigue, and weight loss. Diagnosis typically involves imaging studies such as X-rays, CT scans, or MRI scans to locate the tumor, followed by a biopsy to confirm the presence of cancer cells. Treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these approaches, depending on the stage and location of the disease.

Ewing Sarcoma (EWS) RNA-Binding Protein, also known as EWSR1, is a protein that plays a role in gene expression by binding to RNA. It is a member of the FET family of proteins, which also includes FUS and TAF15. These proteins are involved in various cellular processes such as transcription, splicing, and translation.

Mutations in the EWSR1 gene have been associated with several types of cancer, most notably Ewing sarcoma, a rare tumor that typically affects children and adolescents. In Ewing sarcoma, a fusion protein is formed when EWSR1 combines with another protein, most commonly ETS translocation variant 1 (ETV1), FLI1, ERG or FEV. This fusion protein can lead to abnormal gene expression and tumor formation.

EWSR1 has also been found to be involved in other types of cancer such as acute myeloid leukemia, clear cell sarcoma, desmoplastic small round cell tumors and liposarcomas.

It's important to note that while EWSR1 is a RNA-binding protein, it can also bind to DNA in certain contexts, such as when it forms a fusion protein with an ETS transcription factor in Ewing sarcoma.

Neuroectodermal tumors, primitive (PNETs) are a group of highly malignant and aggressive neoplasms that arise from neuroectodermal cells, which are the precursors to the nervous system during embryonic development. These tumors can occur anywhere in the body but are most commonly found in the central nervous system, particularly in the brain and spinal cord.

PNETs are characterized by small, round, blue cells that have a high degree of cellularity and mitotic activity. They are composed of undifferentiated or poorly differentiated cells that can differentiate along various neural lineages, including neuronal, glial, and epithelial. This feature makes their diagnosis challenging, as they can resemble other small round blue cell tumors, such as lymphomas, rhabdomyosarcomas, and Ewing sarcoma.

Immunohistochemical staining and molecular genetic testing are often required to confirm the diagnosis of PNETs. These tests typically reveal the expression of neural markers, such as NSE, Synaptophysin, and CD99, and the presence of specific chromosomal abnormalities, such as the EWS-FLI1 fusion gene in Ewing sarcoma.

PNETs are aggressive tumors with a poor prognosis, and their treatment typically involves a multimodal approach that includes surgery, radiation therapy, and chemotherapy. Despite these treatments, the five-year survival rate for patients with PNETs is less than 30%.

Rhabdomyosarcoma, embryonal is a type of soft tissue sarcoma, which is a cancer that develops in the body's connective tissues, such as muscles, tendons, ligaments, and cartilage. Specifically, embryonal rhabdomyosarcoma is a subtype of rhabdomyosarcoma that arises from cells that are in the process of becoming muscle cells. This type of cancer typically affects children, with most cases diagnosed before the age of 10.

Embryonal rhabdomyosarcoma can develop in various parts of the body, including the head and neck, genitourinary tract (reproductive and urinary organs), and extremities. The tumors are often aggressive and fast-growing, but they can be treated with a combination of surgery, radiation therapy, and chemotherapy.

The medical definition of embryonal rhabdomyosarcoma is: "A malignant neoplasm composed of small, round to avoid cells with hyperchromatic nuclei and scant cytoplasm, often arranged in a loose, fascicular pattern. It arises from primitive muscle cells and typically affects children and adolescents. The tumor can develop in various parts of the body, including the head and neck, genitourinary tract, and extremities."

Wilms' Tumor 1 (WT1) proteins are a group of transcription factors that play crucial roles in the development of the human body, particularly in the formation of the urinary and reproductive systems. The WT1 gene encodes these proteins, and mutations in this gene have been associated with several diseases, most notably Wilms' tumor, a type of kidney cancer in children.

WT1 proteins contain four domains: an N-terminal transcriptional activation domain, a zinc finger domain that binds to DNA, a nuclear localization signal, and a C-terminal transcriptional repression domain. These proteins regulate the expression of various target genes involved in cell growth, differentiation, and apoptosis (programmed cell death).

Abnormalities in WT1 protein function or expression have been linked to several developmental disorders, including Denys-Drash syndrome, Frasier syndrome, and Wilms' tumor. These conditions are characterized by genitourinary abnormalities, such as kidney dysplasia, ambiguous genitalia, and an increased risk of developing Wilms' tumor.

Chimerin proteins are a group of intracellular signaling proteins that contain a protein kinase C (PKC) phosphorylation site and a GTPase-activating protein (GAP) domain, which regulates Rho GTPases. These proteins play important roles in various cellular processes such as neurite outgrowth, axon guidance, and synaptic plasticity. They are named "chimerin" because they contain domains derived from two different proteins: the N-terminal region is similar to that of a neuronal protein called semaphorin 4D, while the C-terminal region contains the GAP domain found in Ras GTPase-activating proteins. There are several isoforms of chimerin proteins, including Chimerin1 (Chn1), Chimerin2 (Chn2), and Chimerin3 (Chn3), which differ in their tissue distribution and subcellular localization.

Carcinoma, small cell is a type of lung cancer that typically starts in the bronchi (the airways that lead to the lungs). It is called "small cell" because the cancer cells are small and appear round or oval in shape. This type of lung cancer is also sometimes referred to as "oat cell carcinoma" due to the distinctive appearance of the cells, which can resemble oats when viewed under a microscope.

Small cell carcinoma is a particularly aggressive form of lung cancer that tends to spread quickly to other parts of the body. It is strongly associated with smoking and is less common than non-small cell lung cancer (NSCLC), which accounts for about 85% of all lung cancers.

Like other types of lung cancer, small cell carcinoma may not cause any symptoms in its early stages. However, as the tumor grows and spreads, it can cause a variety of symptoms, including coughing, chest pain, shortness of breath, hoarseness, and weight loss. Treatment for small cell carcinoma typically involves a combination of chemotherapy, radiation therapy, and sometimes surgery.

Peritoneal neoplasms refer to tumors or cancerous growths that develop in the peritoneum, which is the thin, transparent membrane that lines the inner wall of the abdomen and covers the organs within it. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant peritoneal neoplasms are often associated with advanced stages of gastrointestinal, ovarian, or uterine cancers and can spread (metastasize) to other parts of the abdomen.

Peritoneal neoplasms can cause various symptoms such as abdominal pain, bloating, nausea, vomiting, loss of appetite, and weight loss. Diagnosis typically involves imaging tests like CT scans or MRIs, followed by a biopsy to confirm the presence of cancerous cells. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these approaches, depending on the type, stage, and location of the neoplasm.

An oncogene protein fusion is a result of a genetic alteration in which parts of two different genes combine to create a hybrid gene that can contribute to the development of cancer. This fusion can lead to the production of an abnormal protein that promotes uncontrolled cell growth and division, ultimately resulting in a malignant tumor. Oncogene protein fusions are often caused by chromosomal rearrangements such as translocations, inversions, or deletions and are commonly found in various types of cancer, including leukemia and sarcoma. These genetic alterations can serve as potential targets for cancer diagnosis and therapy.

Alveolar Rhabdomyosarcoma (ARMS) is a type of soft tissue sarcoma, which is a rare cancer that affects the muscles and connective tissues. ARMS is characterized by the presence of specific genetic alterations involving the PAX3 or PAX7 genes, which are fused with the FOXO1 gene. These genetic changes lead to the formation of abnormal proteins that promote uncontrolled cell growth and division, resulting in the development of tumors.

ARMS typically affects children and adolescents, although it can occur in adults as well. The most common sites for ARMS include the extremities, trunk, head, and neck. The alveolar subtype is named for its histological resemblance to lung tissue, with tumors forming small, thin-walled cavities or spaces that look like the air sacs (alveoli) in the lungs.

ARMS tends to be more aggressive than other types of rhabdomyosarcoma and has a higher risk of metastasis (spreading to other parts of the body). Treatment usually involves a combination of surgery, radiation therapy, and chemotherapy. The prognosis for ARMS depends on several factors, including the patient's age, the size and location of the tumor, and the extent of spread at the time of diagnosis.

Rhabdomyosarcoma is a type of cancer that develops in the body's soft tissues, specifically in the muscle cells. It is a rare and aggressive form of sarcoma, which is a broader category of cancers that affect the connective tissues such as muscles, tendons, cartilages, bones, blood vessels, and fatty tissues.

Rhabdomyosarcomas can occur in various parts of the body, including the head, neck, arms, legs, trunk, and genitourinary system. They are more common in children than adults, with most cases diagnosed before the age of 18. The exact cause of rhabdomyosarcoma is not known, but genetic factors and exposure to radiation or certain chemicals may increase the risk.

There are several subtypes of rhabdomyosarcoma, including embryonal, alveolar, pleomorphic, and spindle cell/sclerosing. The type and stage of the cancer determine the treatment options, which may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Early diagnosis and prompt treatment are crucial for improving the prognosis and long-term survival rates.

Heterogeneous Nuclear Ribonucleoproteins (hnRNPs) are a type of nuclear protein complex associated with nascent RNA transcripts in the nucleus of eukaryotic cells. They play crucial roles in various aspects of RNA metabolism, including processing, transport, stability, and translation.

The term "heterogeneous" refers to the diverse range of proteins that make up these complexes, while "nuclear" indicates their location within the nucleus. The hnRNPs are composed of a core protein component and associated RNA molecules, primarily heterogeneous nuclear RNAs (hnRNAs) or pre-messenger RNAs (pre-mRNAs).

There are over 20 different hnRNP proteins identified so far, each with distinct functions and structures. Some of the well-known hnRNPs include hnRNP A1, hnRNP C, and hnRNP U. These proteins contain several domains that facilitate RNA binding, protein-protein interactions, and post-translational modifications.

The primary function of hnRNPs is to regulate gene expression at the post-transcriptional level by interacting with RNA molecules. They participate in splicing, 3' end processing, export, localization, stability, and translation of mRNAs. Dysregulation of hnRNP function has been implicated in various human diseases, including neurological disorders and cancer.

Neuroectodermal tumors, primitive, peripheral (PNET) are a group of rare and aggressive malignancies that primarily affect children and young adults. These tumors arise from the primitive neuroectodermal cells, which are the precursors to the nervous system. PNETs can occur in various locations throughout the body, but when they occur outside the central nervous system (CNS), they are referred to as peripheral PNETs (pPNETs).

Peripheral PNETs are similar to Ewing sarcoma, another type of small, round blue cell tumor that arises from primitive neuroectodermal cells. In fact, some researchers consider pPNETs and Ewing sarcomas to be part of the same disease spectrum, known as the Ewing family of tumors (EFT).

Peripheral PNETs can occur in any part of the body, but they most commonly affect the bones and soft tissues of the trunk, extremities, and head and neck region. The symptoms of pPNET depend on the location and size of the tumor, but they may include pain, swelling, decreased mobility, and systemic symptoms such as fever and weight loss.

The diagnosis of pPNET typically involves a combination of imaging studies (such as MRI or CT scans), biopsy, and molecular testing. The treatment usually involves a multimodal approach that includes surgery, chemotherapy, and radiation therapy. Despite aggressive treatment, the prognosis for patients with pPNET remains poor, with a five-year survival rate of approximately 30%.

Desmoplastic fibroma is a very rare benign (non-cancerous) tumor of the connective tissue. It typically develops in the bones, but can also occur in soft tissues. The tumor is characterized by the overgrowth of collagen-producing cells (fibroblasts), leading to the formation of a firm, fibrous mass. Desmoplastic fibromas are slow-growing and typically do not spread to other parts of the body (metastasize). However, they can cause significant damage to the affected bone or tissue as they grow, potentially leading to fractures or deformities. Treatment usually involves surgical removal of the tumor.

Human chromosome pair 22 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each chromosome is made up of DNA tightly coiled around histone proteins, forming a complex structure called a chromatin.

Chromosome pair 22 is one of the 22 autosomal pairs of human chromosomes, meaning they are not sex chromosomes (X or Y). Chromosome 22 is the second smallest human chromosome, with each arm of the chromosome designated as p and q. The short arm is labeled "p," and the long arm is labeled "q."

Chromosome 22 contains several genes that are associated with various genetic disorders, including DiGeorge syndrome, velocardiofacial syndrome, and cat-eye syndrome, which result from deletions or duplications of specific regions on the chromosome. Additionally, chromosome 22 is the location of the NRXN1 gene, which has been associated with an increased risk for autism spectrum disorder (ASD) and schizophrenia when deleted or disrupted.

Understanding the genetic makeup of human chromosome pair 22 can provide valuable insights into human genetics, evolution, and disease susceptibility, as well as inform medical diagnoses, treatments, and research.

Proto-oncogene protein c-Fli-1 is a transcription factor that belongs to the ETS family and plays crucial roles in hematopoiesis, vascular development, and cell proliferation. The gene encoding this protein, called c-Fli-1, can be mutated or its expression can be dysregulated, leading to the formation of a proto-oncogene. When this happens, the protein can contribute to the development of various types of cancer, such as Ewing's sarcoma and acute myeloid leukemia. In these cases, the protein promotes cell growth and division, inhibits apoptosis (programmed cell death), and increases angiogenesis (the formation of new blood vessels). Overall, c-Fli-1 is an important regulator of normal cellular processes, but when its activity is deregulated, it can contribute to the development of cancer.

Translocation, genetic, refers to a type of chromosomal abnormality in which a segment of a chromosome is transferred from one chromosome to another, resulting in an altered genome. This can occur between two non-homologous chromosomes (non-reciprocal translocation) or between two homologous chromosomes (reciprocal translocation). Genetic translocations can lead to various clinical consequences, depending on the genes involved and the location of the translocation. Some translocations may result in no apparent effects, while others can cause developmental abnormalities, cancer, or other genetic disorders. In some cases, translocations can also increase the risk of having offspring with genetic conditions.

Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) is a laboratory technique used in molecular biology to amplify and detect specific DNA sequences. This technique is particularly useful for the detection and quantification of RNA viruses, as well as for the analysis of gene expression.

The process involves two main steps: reverse transcription and polymerase chain reaction (PCR). In the first step, reverse transcriptase enzyme is used to convert RNA into complementary DNA (cDNA) by reading the template provided by the RNA molecule. This cDNA then serves as a template for the PCR amplification step.

In the second step, the PCR reaction uses two primers that flank the target DNA sequence and a thermostable polymerase enzyme to repeatedly copy the targeted cDNA sequence. The reaction mixture is heated and cooled in cycles, allowing the primers to anneal to the template, and the polymerase to extend the new strand. This results in exponential amplification of the target DNA sequence, making it possible to detect even small amounts of RNA or cDNA.

RT-PCR is a sensitive and specific technique that has many applications in medical research and diagnostics, including the detection of viruses such as HIV, hepatitis C virus, and SARS-CoV-2 (the virus that causes COVID-19). It can also be used to study gene expression, identify genetic mutations, and diagnose genetic disorders.

Sarcoma, clear cell, is a rare type of cancer that arises from certain types of connective tissue in the body. It is called "clear cell" because the cancer cells have a clear appearance when viewed under a microscope due to the presence of lipids or glycogen within the cytoplasm.

Clear cell sarcoma can occur in various parts of the body, but it most commonly affects the soft tissues of the extremities, such as the legs and arms. It is an aggressive cancer that tends to spread to other parts of the body, including the lungs, lymph nodes, and bones.

Clear cell sarcoma typically occurs in young adults, with a median age at diagnosis of around 30 years old. The exact cause of this type of sarcoma is not known, but it has been linked to genetic mutations involving the EWSR1 gene. Treatment for clear cell sarcoma usually involves surgery to remove the tumor, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells. Despite treatment, the prognosis for patients with clear cell sarcoma is generally poor, with a five-year survival rate of around 50%.

Liposarcoma, myxoid type, is a specific subtype of liposarcoma, which is a malignant (cancerous) tumor that develops from fat cells. Myxoid liposarcoma is characterized by the presence of a gel-like substance in the tumor tissue. It usually occurs in deep soft tissues, such as muscles, tendons, and ligaments, and can be found in various parts of the body, but it most commonly affects the thigh.

Myxoid liposarcoma tends to grow slowly and has a better prognosis compared to other subtypes of liposarcoma. However, it can still metastasize (spread) to other parts of the body, such as the lungs, bones, and lymph nodes. Treatment typically involves surgical removal of the tumor, with radiation therapy and/or chemotherapy used in some cases to help reduce the risk of recurrence or spread.

It's important to note that while I strive to provide accurate information, my responses should not be used as a substitute for professional medical advice, diagnosis, or treatment.

Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.

Bone neoplasms are abnormal growths or tumors that develop in the bone. They can be benign (non-cancerous) or malignant (cancerous). Benign bone neoplasms do not spread to other parts of the body and are rarely a threat to life, although they may cause problems if they grow large enough to press on surrounding tissues or cause fractures. Malignant bone neoplasms, on the other hand, can invade and destroy nearby tissue and may spread (metastasize) to other parts of the body.

There are many different types of bone neoplasms, including:

1. Osteochondroma - a benign tumor that develops from cartilage and bone
2. Enchondroma - a benign tumor that forms in the cartilage that lines the inside of the bones
3. Chondrosarcoma - a malignant tumor that develops from cartilage
4. Osteosarcoma - a malignant tumor that develops from bone cells
5. Ewing sarcoma - a malignant tumor that develops in the bones or soft tissues around the bones
6. Giant cell tumor of bone - a benign or occasionally malignant tumor that develops from bone tissue
7. Fibrosarcoma - a malignant tumor that develops from fibrous tissue in the bone

The symptoms of bone neoplasms vary depending on the type, size, and location of the tumor. They may include pain, swelling, stiffness, fractures, or limited mobility. Treatment options depend on the type and stage of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.

A Granulosa Cell Tumor is a type of sex cord-stromal tumor, which are uncommon neoplasms that arise from the supporting cells of the ovary or testis. These tumors account for approximately 5% of all ovarian tumors and can occur at any age, but they are most commonly found in perimenopausal and postmenopausal women.

Granulosa cell tumors originate from the granulosa cells, which are normally responsible for producing estrogen and supporting the development of the egg within the ovarian follicle. These tumors can be functional, meaning they produce hormones, or nonfunctional. Functional granulosa cell tumors often secrete estrogen, leading to symptoms such as irregular menstrual periods, postmenopausal bleeding, and, in rare cases, the development of male characteristics (virilization) due to androgen production.

Granulosa cell tumors are typically slow-growing and can vary in size. They are often diagnosed at an early stage because they cause symptoms related to hormonal imbalances or, less commonly, due to abdominal pain or distention caused by the growing mass. The diagnosis is usually confirmed through imaging studies (such as ultrasound, CT, or MRI) and a biopsy or surgical removal of the tumor, followed by histopathological examination.

Treatment for granulosa cell tumors typically involves surgery to remove the tumor and, in some cases, adjacent organs if there is evidence of spread. The role of chemotherapy and radiation therapy is less clear, but they may be used in certain situations, such as advanced-stage disease or high-risk features. Regular follow-up with imaging studies and tumor marker measurements (such as inhibin) is essential due to the risk of recurrence, even many years after initial treatment.

Human chromosome pair 11 consists of two rod-shaped structures present in the nucleus of each cell in the human body. Each member of the pair is a single chromosome, and together they contain the genetic material that is inherited from both parents. They are located on the eleventh position in the standard karyotype, which is a visual representation of the 23 pairs of human chromosomes.

Chromosome 11 is one of the largest human chromosomes and contains an estimated 135 million base pairs. It contains approximately 1,400 genes that provide instructions for making proteins, as well as many non-coding RNA molecules that play a role in regulating gene expression.

Chromosome 11 is known to contain several important genes and genetic regions associated with various human diseases and conditions. For example, it contains the Wilms' tumor 1 (WT1) gene, which is associated with kidney cancer in children, and the neurofibromatosis type 1 (NF1) gene, which is associated with a genetic disorder that causes benign tumors to grow on nerves throughout the body. Additionally, chromosome 11 contains the region where the ABO blood group genes are located, which determine a person's blood type.

It's worth noting that human chromosomes come in pairs because they contain two copies of each gene, one inherited from the mother and one from the father. This redundancy allows for genetic diversity and provides a backup copy of essential genes, ensuring their proper function and maintaining the stability of the genome.

Venereal tumors in veterinary medicine refer to a type of contagious cancer that affects primarily the genitalia of dogs and other canids. These tumors are transmitted through sexual contact or during breeding, and they can also spread through direct contact with tumor cells, such as during licking or biting of the affected area.

The tumors typically appear as firm, nodular masses in the genital region, and they can vary in size from small bumps to large, ulcerated lesions. They are highly vascular, which means that they have a rich blood supply, and this can make them prone to bleeding.

Venereal tumors in dogs are treatable with chemotherapy or radiation therapy, and the prognosis is generally good if the tumors are detected and treated early. However, if left untreated, venereal tumors can grow and spread to other parts of the body, making them more difficult to treat and potentially life-threatening.

It's important to note that venereal tumors are not common in domestic pets other than dogs, and they are rarely seen in cats or other small animals.

A Giant Cell Tumor (GCT) of bone is a relatively uncommon, locally aggressive tumor that can sometimes become malignant. It is characterized by the presence of multinucleated giant cells which are distributed throughout the tumor tissue. These giant cells are thought to be derived from osteoclasts, which are specialized cells responsible for bone resorption.

GCTs typically affect adults in their 20s and 30s, with a slight female predominance. The most common sites of involvement include the long bones near the knee (distal femur and proximal tibia), as well as the distal radius, sacrum, and spine.

The tumor usually presents as pain and swelling in the affected area, sometimes accompanied by restricted mobility or pathological fractures due to bone weakening. The diagnosis is typically made based on imaging studies (such as X-rays, CT scans, or MRI) and confirmed through a biopsy.

Treatment options for GCTs of bone may include intralesional curettage with or without the use of adjuvant therapies (like phenol, liquid nitrogen, or cement), radiation therapy, or surgical resection. In some cases, systemic treatments like denosumab, a monoclonal antibody targeting RANKL, may be used to control the growth and spread of the tumor. Regular follow-ups are essential to monitor for potential recurrence, which can occur in up to 50% of cases within five years after treatment.

Tumor markers are substances that can be found in the body and their presence can indicate the presence of certain types of cancer or other conditions. Biological tumor markers refer to those substances that are produced by cancer cells or by other cells in response to cancer or certain benign (non-cancerous) conditions. These markers can be found in various bodily fluids such as blood, urine, or tissue samples.

Examples of biological tumor markers include:

1. Proteins: Some tumor markers are proteins that are produced by cancer cells or by other cells in response to the presence of cancer. For example, prostate-specific antigen (PSA) is a protein produced by normal prostate cells and in higher amounts by prostate cancer cells.
2. Genetic material: Tumor markers can also include genetic material such as DNA, RNA, or microRNA that are shed by cancer cells into bodily fluids. For example, circulating tumor DNA (ctDNA) is genetic material from cancer cells that can be found in the bloodstream.
3. Metabolites: Tumor markers can also include metabolic products produced by cancer cells or by other cells in response to cancer. For example, lactate dehydrogenase (LDH) is an enzyme that is released into the bloodstream when cancer cells break down glucose for energy.

It's important to note that tumor markers are not specific to cancer and can be elevated in non-cancerous conditions as well. Therefore, they should not be used alone to diagnose cancer but rather as a tool in conjunction with other diagnostic tests and clinical evaluations.

Giant cell tumors (GCTs) are a type of benign or rarely malignant bone tumor that is characterized by the presence of multinucleated giant cells. These tumors typically affect adults between the ages of 20 and 40, and they can occur in any bone, but they most commonly involve the long bones near the knee joint.

GCTs are composed of three types of cells: mononuclear stromal cells, which produce the matrix of the tumor; multinucleated osteoclast-like giant cells, which resemble the bone-resorbing cells found in normal bone; and macrophages, which are part of the body's immune system.

The mononuclear stromal cells produce a variety of growth factors that stimulate the formation and activity of the osteoclast-like giant cells, leading to localized bone destruction. The tumor may cause pain, swelling, and limited mobility in the affected area.

While GCTs are typically benign, they can be aggressive and locally destructive, with a tendency to recur after surgical removal. In some cases, GCTs may undergo malignant transformation, leading to the development of sarcomas. Treatment options for GCTs include curettage (scraping out) of the tumor, followed by bone grafting or the use of a cement spacer to fill the defect, and/or adjuvant therapy with radiation or chemotherapy.

Benign fibrous histiocytoma (BFH) is a common benign tumor of the skin and superficial soft tissues. It primarily affects middle-aged adults and is more prevalent in men than women. The exact cause of BFH is unknown, but it's thought to arise from dermal fibroblasts or histiocytes.

Medical Definition: Benign Fibrous Histiocytoma (BFH) is a benign, slowly growing, solitary cutaneous or subcutaneous nodular tumor predominantly composed of a mixture of fibroblastic and histiocytic-like cells. The tumor typically presents as a well-circumscribed, firm, dome-shaped papule or nodule, ranging in size from a few millimeters to several centimeters. Histologically, BFH is characterized by the proliferation of spindle-shaped fibroblasts and histiocytes arranged in a storiform pattern, along with variable amounts of collagen deposition, multinucleated giant cells, and hemosiderin deposits. The lesion usually has a pushing border with no invasion into the surrounding tissues. BFH generally follows a benign clinical course, with local recurrence being uncommon following complete surgical excision.

A mastocytoma is a type of tumor that develops from mast cells, which are a part of the immune system and play a role in allergic reactions and inflammation. Mastocytomas are most commonly found in the skin, but they can also occur in other organs such as the liver, spleen, and lymph nodes.

Mastocytomas are usually benign (non-cancerous), although malignant (cancerous) forms known as mast cell sarcomas can also occur. They typically appear as raised, red or brown lesions on the skin that may be itchy, painful, or bleed easily.

The diagnosis of a mastocytoma is usually made through a biopsy of the tumor, which involves removing a small sample of tissue for examination under a microscope. Treatment options for mastocytomas may include surgical removal, medication to manage symptoms such as itching or flushing, and in some cases, chemotherapy or radiation therapy.

Histiocytic sarcoma is a rare type of cancer that originates from histiocytes, which are cells that are part of the immune system and found in various tissues throughout the body. These cells normally function to help fight infection and remove foreign substances. In histiocytic sarcoma, there is an abnormal accumulation and proliferation of these cells, leading to the formation of tumors.

Histiocytic sarcoma can affect people of any age but is more commonly found in adults, with a slight male predominance. It can occur in various parts of the body, such as the lymph nodes, skin, soft tissues, and internal organs like the spleen, liver, and lungs. The exact cause of histiocytic sarcoma remains unknown, but it is not considered to be hereditary.

The symptoms of histiocytic sarcoma depend on the location and extent of the tumor(s). Common signs include swollen lymph nodes, fatigue, fever, weight loss, night sweats, and pain or discomfort in the affected area. Diagnosis typically involves a combination of imaging studies (like CT scans, PET scans, or MRI), biopsies, and laboratory tests to confirm the presence of histiocytic sarcoma and assess its extent.

Treatment for histiocytic sarcoma usually involves a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. The choice of treatment depends on several factors, such as the location and stage of the disease, the patient's overall health, and their personal preferences. Clinical trials may also be an option for some patients, allowing them to access new and experimental therapies.

Prognosis for histiocytic sarcoma is generally poor, with a five-year survival rate of approximately 15-30%. However, outcomes can vary significantly depending on individual factors, such as the patient's age, the extent of the disease at diagnosis, and the effectiveness of treatment. Continued research is necessary to improve our understanding of this rare cancer and develop more effective therapies for those affected.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Diagnostic errors refer to inaccurate or delayed diagnoses of a patient's medical condition, which can lead to improper or unnecessary treatment and potentially serious harm to the patient. These errors can occur due to various factors such as lack of clinical knowledge, failure to consider all possible diagnoses, inadequate communication between healthcare providers and patients, and problems with testing or interpretation of test results. Diagnostic errors are a significant cause of preventable harm in medical care and have been identified as a priority area for quality improvement efforts.

Sarcoma is a type of cancer that develops from certain types of connective tissue (such as muscle, fat, fibrous tissue, blood vessels, or nerves) found throughout the body. It can occur in any part of the body, but it most commonly occurs in the arms, legs, chest, and abdomen.

Sarcomas are classified into two main groups: bone sarcomas and soft tissue sarcomas. Bone sarcomas develop in the bones, while soft tissue sarcomas develop in the soft tissues of the body, such as muscles, tendons, ligaments, fat, blood vessels, and nerves.

Sarcomas can be further classified into many subtypes based on their specific characteristics, such as the type of tissue they originate from, their genetic makeup, and their appearance under a microscope. The different subtypes of sarcoma have varying symptoms, prognoses, and treatment options.

Overall, sarcomas are relatively rare cancers, accounting for less than 1% of all cancer diagnoses in the United States each year. However, they can be aggressive and may require intensive treatment, such as surgery, radiation therapy, and chemotherapy.

... desmoplastic small round blue cell tumor; intra-abdominal desmoplastic small round blue cell tumor; desmoplastic small cell ... "Orphanet: Desmoplastic small round cell tumor". www.orpha.net. Retrieved 17 November 2019. "Desmoplastic Small Round Cell Tumor ... "Establishment and characterization of a novel human desmoplastic small round cell tumor cell line, JN-DSRCT-1". Laboratory ... Desmoplastic small-round-cell tumor (DSRCT) is an aggressive and rare cancer that primarily occurs as masses in the abdomen. ...
... signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing's sarcoma (EWS/FLI1) and Wilms' tumor(WT1)". PLOS One ... Andrea Hayes-Jordan; Peter M Anderson (1 July 2011). "The diagnosis and management of desmoplastic small round cell tumor: a ... Andrea Hayes-Jordan; Michael P LaQuaglia; Shakeel Modak (14 September 2016). "Management of desmoplastic small round cell tumor ... 19 November 2011). "Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after ...
... desmoplastic small-round-cell tumor. Sheilla Lampkin, 70, American politician, member of the Arkansas House of Representatives ... Mary A. McClure, 77, American politician, small-cell carcinoma. Carlos Morocho Hernández, 76, Venezuelan WBA and WBC super ... Lisa Gaye, 81, American actress, singer and dancer (Rock Around the Clock, Drums Across the River). Miguel Gutiérrez, 75, ... Doris Benegas, 64, Venezuelan-born Spanish Basque politician, leader of the Castilian Left, abdominal tumor. Keith L. Brown, 91 ...
It is usually used in the description of desmoplastic small round cell tumors. Neoplasia is the medical term used for both ... MMPs also degrade ECM to provide space for vasculature to grow to the tumor, for the tumor cells to migrate, and for the tumor ... Source: Desmoplastic melanocytic naevus Desmoplastic spitz naevus Desmoplastic cellular blue naevi Desmoplastic hairless ... or parenchymal cells of epithelia, are highly organized, polar cells. These cells are separated from stromal cells by a ...
"EWS and WT-1 gene fusion in desmoplastic small round cell tumor of the abdomen". Hum. Pathol. 26 (12): 1370-4. doi:10.1016/0046 ... malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel ... malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel ... Ohno T, Ouchida M, Lee L, Gatalica Z, Rao VN, Reddy ES (Oct 1994). "The EWS gene, involved in Ewing family of tumors, ...
Actress Michelle Thomas died from desmoplastic small-round-cell tumor, a rare abdominal soft-tissue sarcoma. It Is Written ... Connective/soft tissue tumors and sarcomas, Sarcoma, Soft tissue tumor). ... As the tumor grows, it may cause other symptoms, such as pain or soreness, as it presses against nearby nerves and muscles. If ... The stage of the sarcoma is based on the size and grade of the tumor, and whether the cancer has spread to the lymph nodes or ...
Desmoplastic small-round-cell tumors: These tumors' neoplastic cells consistently express the EWSR1-WT1 fusion gene. Myxoid ... Clear cell sarcoma-like gastrointestinal tumor (also termed gastrointestinal neuroectodermal tumor): The neoplastic cells in ... Mesothelioma: A small subset of these tumors have neoplastic cells that express a EWSR1-CREB fusion gene or, in fewer cases, a ... Epithelioid and spindle cell rhabdomyosarcoma with EWSR1/FUS-TFCP2 Fusion: These newly described tumors are regarded as a small ...
In August 1997, Thomas was diagnosed with a rare cancer, an intra-abdominal desmoplastic small-round-cell tumor (DSRCT). Thomas ... has died as a result of a desmoplastic small round tumor, a rare form of cancer, at age 29. Michelle Thomas at IMDb Michelle ... Thomas had a role in Dream Date in 1989 and had a small role in Hangin' with the Homeboys in 1991. Thomas appeared in music ... Her body couldn't take it." Thomas underwent surgery to remove a lemon-sized tumor shortly before landing her The Young and the ...
... reticulum cell sarcomas, desmoplastic small round cell tumor, and liposarcomas. Angiosarcoma is the most common primary cardiac ... Metastatic tumors to the heart are about 20 times more common than primary cardiac tumors. The most common primary tumor of the ... A subset of the primary tumors of the heart are tumors that are found on the valves of the heart. Tumors that affect the valves ... Primary tumors of the valves of the heart are more likely to occur in males. While most primary tumors of the valves of the ...
... and desmoplastic small round cell tumor, among others.[citation needed] On conventional radiographs, typical findings of Ewing ... In the group of malignant small round cell tumors that includes Ewing sarcoma, bone lymphoma, and small cell osteosarcoma, the ... Ewing sarcoma is a small-blue-round-cell tumor that typically has a clear cytoplasm on H&E staining, due to glycogen. The ... The pathologic differential diagnosis is the grouping of small-blue-round-cell tumors, which includes lymphoma, alveolar ...
In 2011 she was diagnosed with desmoplastic small-round-cell tumor (DSRCT), a type of sarcoma, and subsequently started the "# ... I am a little bit psychologically scarred by that experience. Granger was the subject the second ever Dying Matters Annual ...
... involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA ... "A novel zinc finger gene is fused to EWS in small round cell tumor". Oncogene. 19 (33): 3799-804. doi:10.1038/sj.onc.1203762. ... Essentially TMPRSS2-ERG fusion disrupts the ability of the cells to differentiate into proper prostate cells creating ... produced resulting in unnatural activity in cells. Typically this is the first step in a cell's progression to malignancy. In ...
... discoverer of Rosai-Dorfman disease and desmoplastic small round cell tumor Richard Selzer (1960-1985): surgeon and author ... cell biologist, Sterling Professor of Cell Biology, 1974 Nobel Prize in Physiology and Medicine William Prusoff: discovered ... Chairman of the Department of Cell Biology, winner of the 2013 Nobel Prize in Physiology or Medicine Lisa Sanders: The New York ... cell biologist, first woman Sterling Professor at Yale Stephen Fleck (1912-2002): psychiatrist, coauthor of Schizophrenia and ...
... discoverer of several entities such as Rosai-Dorfman disease and desmoplastic small round cell tumor Alexander Rudensky (Tri- ... and Cell Biology at Cornell, later deputy provost at University of Chicago, noted for Advanced Photon Source and Time resolved ... discovery of a form of malignant bone tumor that later became known as Ewing sarcoma Don W. Fawcett (chair of the Department of ... Assistant Professor of Cell Biology and Genetics; Assistant Professor of Neuroscience 1999 - 2004) - recipient of The Brain ...
... lateral sclerosis Breast cancer Cat eye syndrome Chronic myeloid leukemia DiGeorge Syndrome Desmoplastic small round cell tumor ... Humans normally have two copies of chromosome 22 in each cell. Chromosome 22 is the second smallest human chromosome, spanning ... A small percentage of affected individuals have shorter deletions in the same region. The loss of one particular gene, TBX1, is ... A small extra chromosome is made up of genetic material from chromosome 22 that has been abnormally duplicated (copied). The ...
Tumors that belong to this group are: Desmoplastic small-round-cell tumour Ewing sarcoma/PNET Neuroblastoma Medulloblastoma ... a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a small-round-cell ... tumour Retinoblastoma[citation needed] Small-cell lymphoma Hepatoblastoma- only the anaplastic form has round blue cells, the ... February 2007). "Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction". The Journal of ...
Mesothelial tumors: pleural malignant mesothelioma. Pleural sarcomas Pleural angiosarcoma Pleural desmoplastic small round cell ... Pleural tumors may be benign (i.e. solitary fibrous tumor) or malignant in nature. Pleural mesothelioma is a type of malignant ... tumor (pleural DSRCT) Pleural synovial sarcoma Pleural solitary fibrous tumor (pleural SFT, can be benign or less commonly ... "Pleural Tumors - Health Encyclopedia - University of Rochester Medical Center". www.urmc.rochester.edu. URMC. Retrieved 22 July ...
... desmoplastic small round cell tumor, spindle-cell epithelial tumor with thymus-like differentiation of the thyroid, and ... and he characterized novel medical conditions such as Rosai-Dorfman disease and the desmoplastic small round cell tumor. Rosai ... Gerald, WL; Rosai, J. (1989). "Case 2. Desmoplastic small cell tumor with divergent differentiation". Pediatric Pathology. 9 (2 ... and author of AFIP fascicles on Tumors of the Thymus and Tumors of the Thyroid Gland, and a book on the history of American ...
Long-term remission after CD34+-selected PBSCT in a patient with advanced intra-abdominal desmoplastic small round-cell tumor. ... h.c. Roland Mertelsmann R. Mertelsmann: Plasticity of bone marrow-derived stem cells. In: J Hematother Stem Cell Res. 2000 Dec; ... The "Plasticity" of hematopoietic stem cells (HSC), i.e. the differentiation of HSC into cells of other organs, was intensively ... A phase-I clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in ...
... pathology and discoverer of medical conditions such as the Rosai-Dorfman disease and desmoplastic small round cell tumor, ... Articles using small message boxes, University of Minnesota people, University of Minnesota alumni, Lists of people by ...
... peripheral nerve sheath and gastrointestinal stromal tumors, 35% Adenocarcinoma, 16% Desmoplastic small round cell tumor A ... Benign tumors: Leiomyoma Lipoma Vascular and neuromuscular hamartoma Malignant tumors: Carcinoids: most common, 44% Mesenchymal ... This blind segment or small pouch is about 3-6 cm (2 inch) long and may have a greater lumen diameter than that of the ileum. ... Tumors e.g. carcinoma: direct spread of an adenocarcinoma arising in the diverticulum may lead to obstruction Lithiasis, stones ...
... discoverer of Rosai-Dorfman disease and the desmoplastic small round cell tumor. Gustave Roussy (1874-1948), Swiss-French ... Max Askanazy (1865-1940), German pathologist (see Askanazy cell). E. Ask-Upmark, 20th-century Swedish pathologist (see Ask- ... Fritz Brenner (1877-1969), German pathologist (see Brenner tumor). Alexander Breslow (1928-1980), American pathologist (see ...
... who was diagnosed with desmoplastic small-round-cell tumor (a type of sarcoma), explains how the use of military language, ...
Desbuquois syndrome Desmin-related myofibrillar myopathy Desmoid disease Desmoid tumor Desmoplastic small round cell tumor ... Deafness hypogonadism syndrome Deafness hypospadias metacarpal and metatarsal syndrome Deafness mesenteric diverticula of small ...
Solid tumor cancers Neuroblastoma Desmoplastic small round cell tumor Ewing's sarcoma Choriocarcinoma Hematologic disease ... "Conditions stem cell transplant can cure". INDHEAL. (Stem cells). ... Immunodeficiencies T-cell deficiencies Ataxia-telangiectasia DiGeorge syndrome Combined T- and B-cell deficiencies Severe ... Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. Malignancies ...
... desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. Non- ... The red blood cells are returned to the donor. The peripheral stem cell yield is boosted with daily subcutaneous injections of ... Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research ... Memorial Sloan-Kettering Cancer Center > Blood & Marrow Stem Cell Transplantation > The Graft-versus-Tumor Effect Archived 4 ...
... discovered the desmoplastic small round cell tumor and Rosai-Dorfman disease Jonas Salk (1914-1995) - developed a vaccine for ... tumor Samuel Alexander Kinnier Wilson - Wilson's disease John Bodkin Adams - British general practitioner; suspected serial ... neurosurgeon who invented the modern technique for removing brain tumors Sir William Refshauge (1913-2009) - Australian public ...
... desmoid tumor - desmoplastic - desmoplastic melanoma - desmoplastic small round cell tumor - dexamethasone - dexmethylphenidate ... tumor load - tumor marker - tumor model - tumor necrosis factor - tumor suppressor gene - tumor-derived - tumor-specific ... tumor - tumor antigen vaccine - tumor board review - tumor burden - tumor debulking - tumor infiltrating lymphocyte - ... cell - cell differentiation - cell motility - cell proliferation - cell respiration - cell adhesion - cellular adoptive ...
... small cell carcinoma of hypercalcemic type, primitive neuroectodermal tumor, Wilm's tumor, desmoplastic small round cell tumor ... They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs). They are divided into ... These cells can develop into a frankly malignant tumor known as yolk sac tumor or endodermal sinus tumor. Adequate follow-up ... All tumors of this class are the result of abnormal development of pluripotent cells: germ cells and embryonal cells. Teratomas ...
Desmoplastic small round cell tumor Liposarcoma Lists of diseases List of oncology-related terms [1] National Cancer Institute ... cell lung carcinoma Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Non-small cell ... T-cell prolymphocytic leukemia Basal cell carcinoma Squamous cell carcinoma Squamous cell skin cancer Skin adnexal tumors (e.g ... islet cell Rectal cancer Small intestine cancer Bladder cancer Cervical cancer Endometrial cancer Extragonadal germ cell tumor ...
... desmoplastic small round blue cell tumor; intra-abdominal desmoplastic small round blue cell tumor; desmoplastic small cell ... "Orphanet: Desmoplastic small round cell tumor". www.orpha.net. Retrieved 17 November 2019. "Desmoplastic Small Round Cell Tumor ... "Establishment and characterization of a novel human desmoplastic small round cell tumor cell line, JN-DSRCT-1". Laboratory ... Desmoplastic small-round-cell tumor (DSRCT) is an aggressive and rare cancer that primarily occurs as masses in the abdomen. ...
Desmoplastic small round cell tumour; Desmoplastic small round blue cell tumor; Desmoplastic small round blue cell tumour; ... Intraabdominal desmoplastic small round blue cell tumor; Desmoplastic small cell tumor; Desmoplastic cancer; Desmoplastic ... Review articles on Desmoplastic small round cell tumor Articles on Desmoplastic small round cell tumor in N Eng J Med, Lancet, ... Differentiating Desmoplastic Small Round Cell Tumor from other Diseases. *Desmoplastic small round cell tumor in the abdomen ...
Luke was diagnosed with Desmoplastic small-round-cell tumour, a rare cancer. After various surgeries and months of chemo and ... Luke was diagnosed with Desmoplastic small-round-cell tumour, a rare cancer. After various surgeries and months of chemo and ... Desmoplastic Small-Round-Cell Tumour (1 films) *Soft Tissue Sarcoma (52) *Desmoplastic Small-Round-Cell Tumour (1) ...
Desmoplastic small round cell tumor. Islands of small blue cells are separated by bands of fibrous tissue. View Media Gallery ... The differential diagnoses also include other "small round blue cell tumors" such as small cell carcinoma, small cell variant ... How is the small cell variant of mesothelioma differentiated from pleural desmoplastic small round cell tumor (DSRCT)? ... Desmoplastic small round cell tumor. Islands of small blue cells are separated by bands of fibrous tissue. ...
The peritoneum is a serous lining of mesothelial cells with a rich vascular and lymphatic capillary network that covers the ... Desmoplastic small round cell tumor. This tumor is a highly aggressive malignancy that has recently been described. It involves ... Desmoplastic small round cell tumour: a review of literature and treatment options. Surg Oncol. 2008 Aug. 17(2):107-12. [QxMD ... Desmoplastic small round cell tumor: extra abdominal and abdominal presentations and the results of treatment. Indian J Cancer ...
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Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive variety of sarcoma arising typically ... Devyani Ambadekar, "Desmoplastic Small Round Cell Tumour: A Rare Entity", International Journal of Science and Research (IJSR ... Desmoplastic Small Round Cell Tumour: A Rare Entity. Dr. Kanchan Kshirsagar , Dr. Devyani Ambadekar ... Abstract: Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive variety of sarcoma arising typically ...
Desmoplastic Small Round Cell Tumors (DSRCT) Froedtert & the Medical College of Wisconsin specialists diagnose and treat ... Diagnosing Brain and Spine Tumors Our team uses advanced imaging and molecular analysis to determine the specific type of tumor ... that can damage the small blood vessels in the retina, causing vision loss. ...
Dive into the research topics of FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during ... FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during treatment and at follow-up. ...
Ovarian desmoplastic small round cell tumors: Prognosis is poor! Case report (Articles) ... Desmoid Tumor of the Pelvis in Children: One Case Report (Articles) Hana El Mansouri, Amal Zourair, Hanane Hammaoui, Salma ... Rare tumor of the ovary: Primitive choriocarcinoma (Articles) Sanâa Errarhay, Najia Hmidani, Samia Mahmoud, Hind El Fatemi, ... Primitive Neuroectodermal Tumors of the Vulva in a Pregnant Woman: Case Report and Review of the Literature (Articles) ...
Desmoplastic Small Round Cell Tumors: Investigation of its Pathogenesis and Development of Novel Therapies Memorial Sloan- ... Pre-Targeted Radioimmunotherapy for Desmoplastic Small Round Cell Tumors Memorial Sloan-Kettering Cancer Center / Madelyn ... Mechanisms to Redirect Tumor Associated Macrophages to Target Retinoblastoma Cells The Regents of the University of Minnesota ... In Situ CD19.CAR-T Generation Using TRIDENT System for Pediatric B Cell Malignancies Baylor College of Medicine / Masataka ...
Desmoplastic Small Cell Tumor * Desmoplastic Small Round Cell Tumors * Diamond Blackfan Anemia ... Kupfer has been published in several prestigious publications including BLOOD, Molecular Cell, Nature, and Cell Reports. He is ...
The most shocking part was that Jamess specific type of sarcoma, desmoplastic small round cell tumor (DSRCT), is a rare and ... Desmoplastic small round cell tumor caregiver: How my husband and I confronted sarcoma together ...
Differentiated soft tissue tumors. Undifferentiated sarcomas. Rhabdomyosarcoma. Desmoplastic small round cell tumor. Round cell ... Differentiated soft tissue tumors with small cell features include rhabdomyosarcoma, desmoplastic small round cell tumor (DSRCT ... Tumor cells are characterized as small round blue cells (a). On ThinPrep the small tumor cells can be easily mistaken for ... Desmoplastic small round cell tumor (DSRCT) involving peritoneal fluid. Tumor cells are shown forming a cohesive cluster (a). ...
CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors. Ingo Hartlapp, Philipp E. Hartrampf, ... C-X-C Motif Chemokine Receptor 4-Targeted Radioligand Therapy in Patients with Advanced T-Cell Lymphoma ... Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine ...
CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors.. J Nucl Med. 2023;64:1424-1430.. PubMed ... Evaluation of treatment response by Hopkins criteria on18F FDG PET-CT in patients of non-small cell lung cancer and its ... PET-Derived Increased Inflammation in Large Vessels is linked to Relapse-Free Survival in Patients with Giant Cell Arteritis.. ... Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy.. J Nucl Med. 2023;64:1449-1455. ...
Posted in Awareness, Childhood Cancer, Gold Ribbon Hero , Tagged desmoplastic small round cell tumor, DSRCT, sarcoma, sarcoma ... Meet Preston, a Desmoplastic Small Round Cell Tumor (DSRCT) hero.. On Christmas Eve in 2015, Preston was rushed to the ... During Prestons cancer journey, he endured 54 rounds of chemotherapies and 45 sessions of radiation in his abdominal area. He ...
Desmoplastic Small Round-Cell Tumor (DSRCT). A sarcoma distantly related to Ewing sarcoma that starts and travels in the ... Inflammatory myofibroblastic tumor is a similar tumor to inflammatory forms of fibrosarcoma, in which the tumor cells have both ... thus linking these tumors together through a common pathway of activation of the tumor cell. A cousin of this tumor, which ... Another group of tumors once thought to arise from cells around blood vessels, hemangiopericytoma, is now termed solitary ...
Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen. Pediatr Blood Cancer 65(1), ... Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient ... Desmoplastic Small Round Cell Tumor Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Results ... Improved 3 and 5 Year Survival with Multimodality Treatment of Desmoplastic Small Round Cell Tumor. CTOS Rome, Italy, 2018. ...
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive malignant small cell neoplasm occurring mainly in the ... Bilateral Presentation of Pleural Desmoplastic Small Round Cell Tumors: A Case Report Won YS, Park JS, Jeong SH, Paik SH, Lee H ... Multiple primary tumors at adjacent site are rare. We report a rare case of coincidentally found nasopharyngeal cancer and ... and little is known about them. This study was conducted to determine the... ...
... and temozolomide for pediatric patients with newly diagnosed desmoplastic small round cell tumor. Pediatr Blood Cancer. 2020 10 ... Outcomes of adolescent males with extracranial metastatic germ cell tumors: A report from the Malignant Germ Cell Tumor ... a-Fetoprotein as a predictor of outcome for children with germ cell tumors: A report from the Malignant Germ Cell International ... Application of the adult international germ cell classification system to pediatric malignant non-seminomatous germ cell tumors ...
... of the EWS-WT1 fusion gene transcript in the peritoneal effusion of a patient with desmoplastic small round cell tumor. Chiu, L ... Establishing Clonal Cell Lines with Endothelial-Like Potential from CD9(hi), SSEA-1(-) Cells in Embryonic Stem Cell-Derived ... T-cell post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: another case and a review of ... A model for directed embryonic stem cell differentiation: Establishing lineage-restricted progenitor cell lines. Lian, Q., Lim ...
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy common in young male patient. Typical imaging ... MRI Finding of Retroperitoneal Desmoplastic Small Round Cell Tumor with Hepatic Metastasis and Portal Vein Thrombosis: a Case ... Pancreatoblastoma is a malignant exocrine pancreatic tumor that is usually present in childhood. We herein present one case of ... Clinical presentation and imaging features are non-specific and can mimick the most frequent primary liver tumors... ...
Omburtamab is also being tested in a Phase 2 study for desmoplastic small round cell tumor and we are currently planning a ... an immune checkpoint molecule that is widely expressed in tumor cells of several cancer types. The omburtamab BLA is for the ... including two pivotal-stage product candidates-naxitamab and omburtamab-which target tumors that express GD2 and B7-H3, ...
Foundation also makes donations to support research into the rare form of cancer called desmoplastic small round cell tumour ( ... A Rotary Club helps to make weddings in hospital a little bit special more In response to an appeal by Mid & South Essex ... more Little did Jackie Wellman think that when she started collecting unwanted and unused bikes on behalf of the Re~Cycle ... The Rotary Club of Rayleigh Mill provide a little help to our friends at Trust Links. more Linda Addis, Community Engagement ...
The peritoneum is a serous lining of mesothelial cells with a rich vascular and lymphatic capillary network that covers the ... Desmoplastic small round cell tumor. This tumor is a highly aggressive malignancy that has recently been described. It involves ... Desmoplastic small round cell tumour: a review of literature and treatment options. Surg Oncol. 2008 Aug. 17(2):107-12. [QxMD ... Desmoplastic small round cell tumor: extra abdominal and abdominal presentations and the results of treatment. Indian J Cancer ...
For the three years hed have to watch his childhood friend battle a desmoplastic small round cell tumor, Oct. 29, 2016, was as ... Youre doing little league pitch. And the field is gorgeous.. "Its an awesome little field. Its really a nice spot and its ... Right around (2016-17) and a girl walks in and she was a senior. She gave me a $100 bill. She goes, You know what? This is my ... The Little League scoreboard at Knoch Park is named in honor of Justin Wegner.. The foundation is coming together at Knoch Park ...
"Small, round blue cell tumors" - neuroblastoma, primitive neuroectodermal tumor, intrabdominal desmoplastic round cell tumor; ... tumor, mesoblastic nephroma, others; Pediatric bone and soft tissue tumors- rhabdomyosarcoma, osteosarcoma, others; Germ cell ... pediatric brain tumors, histiocytic disorders-Langerhans cell histiocytosis, Rosai- Dorfman disease, others. ... Prepare and present a case discussion for Pathology Grand Rounds.. Research Skills. *To become involved in studies with senior ...
The actress was diagnosed with Intra-abdominal Desmoplastic Small Round Cell Tumor in 1997, and attempts to eradicate this ... The report further explains that his official cause of death, Stage 4 small cell carcinoma, can spread rapidly before causing ... Most of his live-action roles were of the smaller variety, and in a 2007 interview with the New York Film Academy (via CNN), he ... Hindman had been working in film and television since the late 60s, mainly in smaller roles. He appeared in the 1981 military ...
  • The tumor is classified as a soft tissue sarcoma and a small round blue cell tumor. (wikipedia.org)
  • citation needed] Research has indicated that there is a chimeric relationship between DSRCT and Wilms' tumor and Ewing sarcoma. (wikipedia.org)
  • DSRCT shares characteristics with other small-round blue cell cancers including Ewing's sarcoma, acute leukemia, small cell mesothelioma, neuroblastoma, primitive neuroectodermal tumor, rhabdomyosarcoma, and Wilms' tumor. (wikipedia.org)
  • This is an aggressive, rare, fast spreading tumor and both pediatric and adult patients should be treated at a sarcoma center. (wikipedia.org)
  • There may be a chimeric relationship between desmoplastic small round cell tumor , and Wilms' tumor and Ewing's sarcoma . (wikidoc.org)
  • This tumor is also called desmoplastic small round blue cell tumor, desmoplastic cancer, intraabdominal desmoplastic small round blue cell tumor or desmoplastic sarcoma. (naturalcurefor.com)
  • BACKGROUND: Desmoplastic small round cell tumour (DSRCT) is a rare sarcoma primarily affecting young men. (ox.ac.uk)
  • Desmoplastic small round cell tumour (DSRCT) is a rare and highly aggressive variety of sarcoma arising typically from abdominal or pelvic peritoneum. (ijsr.net)
  • Soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. (dana-farber.org)
  • Ewing sarcoma includes several types of bone tumors. (dana-farber.org)
  • Ewing sarcoma tumors usually form in the hip bones, the ribs, or in the middle of long bones. (dana-farber.org)
  • The most shocking part was that James's specific type of sarcoma, desmoplastic small round cell tumor (DSRCT), is a rare and aggressive form of sarcoma that's usually only seen in kids. (mdanderson.org)
  • An unusual and relatively less aggressive form of sarcoma that shows features of both fibroblasts and cells that retain fat (xanthomas). (sarctrials.org)
  • This unusual hybrid tumor (formerly called melanoma of soft parts) appears to be biologically related to alveolar soft-part sarcoma. (sarctrials.org)
  • It is one of the rare tumors with features of both sarcoma and melanoma, including the ability to travel to lymph nodes (typical of melanoma) and to lung (more common for sarcomas). (sarctrials.org)
  • Though cure is infrequent because of the early spread of this form of sarcoma, patients who do the best are those who respond well to chemotherapy and have all visible signs of their tumor removed. (sarctrials.org)
  • The Foundation also makes donations to support research into the rare form of cancer called desmoplastic small round cell tumour (DSRCT) - a type of sarcoma that affects soft tissues in the body. (rotary-ribi.org)
  • Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience. (viictr.org)
  • As a researcher, Dr Rosai advanced our collective knowledge in numerous fields - his publications provide the first descriptions of many entities (including a disease that bears his name, Rosai-Dorfman disease, and the sarcoma of young adults, desmoplastic small round cell tumour), as well as seminal contributions about more than 75 different entities. (who.int)
  • Desmoplastic small-round-cell tumor (DSRCT) is an aggressive and rare cancer that primarily occurs as masses in the abdomen. (wikipedia.org)
  • DSRCT in young patients can be mistaken for other abdominal tumors including rhabdomyosarcoma, neuroblastoma, and mesenteric carcinoid. (wikipedia.org)
  • In males DSRCT may be mistaken for germ cell or testicular cancer while in females DSRCT can be mistaken for ovarian cancer. (wikipedia.org)
  • DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
  • Also known as DSRCT, it is a very aggressive tumor that occurs rarely, a type of cancer that always grows in the abdomen and spreads locally to the lymph nodes. (naturalcurefor.com)
  • Froedtert & the Medical College of Wisconsin specialists diagnose and treat desmoplastic small round cell tumors (DSRCT) with chemotherapy, surgery and HIPEC. (froedtert.com)
  • Meet Preston, a Desmoplastic Small Round Cell Tumor (DSRCT) hero. (acco.org)
  • Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy common in young male patient. (koreamed.org)
  • The Tom Bowdidge Foundation was founded in 2014 in memory of Tom who died of Desmoplastic Small Round Cell Tumour (DSRCT) in 2013. (icr.ac.uk)
  • Moreover, the fibrous nature of the tumor has given rise to various other names, such as pleural fibroma, submesothelial fibroma, and localized fibrous tumor. (medscape.com)
  • The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
  • Another group of tumors once thought to arise from cells around blood vessels, hemangiopericytoma, is now termed solitary fibrous tumor/hemangiopericytoma, since the tumors all appear to be very similar in terms of their biology. (sarctrials.org)
  • Desmoid tumors are fibrous tumors that usually occur in the tissue covering the intestines and may be provoked by surgery to remove the colon. (wikipedia.org)
  • A right nephrectomy with resection of the mass demonstrated a malignant solitary fibrous tumor. (medscape.com)
  • Together with neuroblastoma and non-Hodgkin's lymphoma, they form the small-cell tumors. (wikipedia.org)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
  • Other tumours, such as neuroblastoma, Wilm tumour, ovarian neuroectodermal tumour or infantile myofibromatosis, have so far been found only in individual cases. (bmj.com)
  • Together, these two new cases show that rhabdomyosarcoma and possibly other embryonic tumours, such as neuroblastoma and Wilm tumour, belong to the tumour spectrum of CMMR-D syndrome. (bmj.com)
  • The Little Princess Trust was set up in 2006 by Wendy and Simon in honour of their daughter Hannah Tarplee who died from Wilms Tumour. (icr.ac.uk)
  • A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage. (lu.se)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • Other treatment options include: hematopoietic stem cell transplantation, intensity-modulated radiation therapy, radiofrequency ablation, stereotactic body radiation therapy, intraperitoneal hyperthermic chemoperfusion, and clinical trials. (wikipedia.org)
  • With other options as intensity-modulated radiation therapy, stereotactic body radiation therapy, clinical trials, intraperitoneal hyperthemic chemoperfusion, and hematopoietic stem cell transplantation. (naturalcurefor.com)
  • Desmoplastic small round cell tumor is an extremely rare, highly aggressive, and malignant neoplasm initially reported by Gerald and Rosai in 1989. (wikidoc.org)
  • Once diagnosed, aggressive chemotherapy is applied and considered the most effective treatment for the tumor. (naturalcurefor.com)
  • Gardner syndrome is also associated with familial adenomatous polyposis and may manifest as aggressive fibromatosis (desmoid tumors) of the retroperitoneum. (wikipedia.org)
  • For those who are not aware, Sofie Lynott is suffering from a rare, and incredibly aggressive form of Cancer known as Desmoplastic Small Round Cell Tumour. (ascensioneagles.com)
  • We will also honor Cancer Warrior, 8 1/2 year old Dominic Liples (www.prayfordominic.com) who valiantly fought a 9-month battle with an aggressive brain tumor and passed away 9 months to the day of his diagnosis. (stbaldricks.org)
  • Some cases of benign and malignant lesions mimicking radiographically periapical lesions, such as keratocystic odontogenic tumors, cysts of the nasopalatine canal, periapical cemental dysplasia, benign tumors and locally aggressive or malignant neoplasias, have been described in the litera- ture (1). (bvsalud.org)
  • The disease rarely occurs in females, but when it does the tumors can be mistaken for ovarian cancer. (wikipedia.org)
  • The tumor appears to arise from the primitive cells of childhood, and is considered a childhood cancer. (wikipedia.org)
  • Luke was diagnosed with Desmoplastic small-round-cell tumour, a rare cancer. (jtvcancersupport.com)
  • The sensitivity of the test results depends on the ability to completely lavage all regions of the peritoneal cavity and to detect cancer cells being shed into the peritoneal cavity by the tumor. (medscape.com)
  • Foods for Desmoplastic Small Round Cell Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. (addon.life)
  • A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is - for cancers like Desmoplastic Small Round Cell Tumor does it matter what foods I eat and which I do not? (addon.life)
  • Or if I follow a plant-based diet is that enough for cancer like Desmoplastic Small Round Cell Tumor? (addon.life)
  • Because different active ingredients contained in foods may have opposing effects on cancer drivers - you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Desmoplastic Small Round Cell Tumor. (addon.life)
  • Deciding which foods are recommended or not is extremely complicated, requiring expertise in Desmoplastic Small Round Cell Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective. (addon.life)
  • Each year, thousands of patients from around the world come to Dana-Farber for their cancer care. (dana-farber.org)
  • Evaluation of treatment response by Hopkins criteria on18F FDG PET-CT in patients of non-small cell lung cancer and its comparison with PERCIST response criteria. (amedeo.com)
  • During Preston's cancer journey, he endured 54 rounds of chemotherapies and 45 sessions of radiation in his abdominal area. (acco.org)
  • Omburtamab is an investigational, monoclonal antibody that targets B7-H3, an immune checkpoint molecule that is widely expressed in tumor cells of several cancer types. (biospace.com)
  • After Aoife Flanagan died of germ cell cancer at the age of three, her mum, Eilish, set up a charity to change the future for other children with cancer. (icr.ac.uk)
  • The members were impressed by Richard and his wife, Nikki's, dedication in helping young cancer sufferers and decided, in some small way, to support the work that they are doing by donating £250 to help them continue with this crucial work. (rotary-ribi.org)
  • [3] The extracolonic tumors may include osteomas of the skull, thyroid cancer , epidermoid cysts , fibromas , [4] as well as the occurrence of desmoid tumors in approximately 15% of affected individuals. (wikipedia.org)
  • Although the tumor was considered to have been fully resected and had not spread to any nodes, the patient died of recurrent cancer within 1 year. (medscape.com)
  • Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)
  • Desmoid tumors arise most frequently from the aponeurosis of the rectus abdominal muscle of multiparous women. (wikipedia.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
  • Desmoplastic small round cell tumor in the abdomen may cause gastrointestinal symptoms and mimic other abdominal tumors . (wikidoc.org)
  • Patient with tumors at the abdomen often have enlarged abdomen associated with pain, vomiting and lost of weight due to lack of appetite, abdominal mass, obstruction in the gastrointestinal area, and patients may become anemic. (naturalcurefor.com)
  • The peritoneum is a common site of metastases for gastrointestinal tumors that predicts a poor outcome. (stanford.edu)
  • These tumors have a high risk of recurring where they start and can also travel to liver, bone, lung, and other sites. (sarctrials.org)
  • The tumor can travel not only elsewhere in the abdominal or pelvic cavity where it starts, but it can also spread to liver, lung, or the space between the lungs (mediastinum). (sarctrials.org)
  • Clinical presentation and imaging features are non-specific and can mimick the most frequent primary liver tumors. (koreamed.org)
  • Froedtert & the Medical College of Wisconsin Eye Institute treats diabetic retinopathy, fluctuations in blood sugar level, that can damage the small blood vessels in the retina, causing vision loss. (froedtert.com)
  • The soft tissues of the body include the muscles, tendons (bands of fiber that connect muscles to bones), fat, blood vessels, lymph vessels, nerves, and tissues around joints. (dana-farber.org)
  • This uncommon group of sarcomas appear to arise from the lining of blood vessels (endothelial cells) or their precursors. (sarctrials.org)
  • The vessels of the lymphatic system are lined with cells very similar to those found in blood vessels and give rise to what is termed lymphangiosarcoma. (sarctrials.org)
  • Renal Cell Carcinoma Unclassified with Medullary Phenotype in a Patient with Neurofibromatosis Type 2. (viictr.org)
  • At surgery, multiple tumour deposits were found throughout abdomen and pelvis. (ox.ac.uk)
  • Dr Rosai also served as founding Editor-in-Chief of the International Journal of Surgical Pathology , as Editor-in-Chief of the 3rd Series of the Atlas of Tumor Pathology of the Armed Forces Institute of Pathology (AFIP Fascicles), and as a significant contributor to multiple tumour classification guidelines for the WHO Classification of Tumours series. (who.int)
  • Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)
  • Primary peritoneal carcinoma is treated with tumor debulking followed by chemotherapy with 5-fluorouracil, doxorubicin, or cisplatin. (medscape.com)
  • Similarly, under Carcinoma, specific renamed or deleted in later revisions of tumour classifications. (who.int)
  • Imaging demonstrated widespread tumour within abdomen and pelvis. (ox.ac.uk)
  • Dr. Andrea Hayes-Jordan performed the 15-hour surgery on Justin at MD Anderson on Dec. 8, 2016 and removed close to 200 tumors from his abdomen and pelvis. (positivelynaperville.com)
  • Other described primary peritoneal cancers and tumors include malignant mesothelioma, benign papillary mesothelioma, desmoplastic small round cell tumors, peritoneal angiosarcoma, leiomyomatosis peritonealis disseminata (LPD), and peritoneal hemangiomatosis. (medscape.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • Children's Tumor Foundation 2022 NF Conference 30(3):3355-3365, 2023. (mdanderson.org)
  • Ewing tumors are most common in bone but can also form in soft tissue. (dana-farber.org)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • Patients are often young and healthy as the tumors grow and spread uninhibited within the abdominal cavity. (wikipedia.org)
  • PET-Derived Increased Inflammation in Large Vessels is linked to Relapse-Free Survival in Patients with Giant Cell Arteritis. (amedeo.com)
  • Clinical Characteristics and Outcomes of Pediatric Patients with Desmoplastic Small Round Cell Tumor. (ucsf.edu)
  • A smaller proportion of medulloblastomas occur in one of the cerebellar hemispheres of patients who are typically older (adolescents or young adults), a subset in which the desmoplastic/nodular variant predominates. (medscape.com)
  • Pathology reveals well circumscribed solid tumor nodules within a dense desmoplastic stroma. (wikipedia.org)
  • Interpretation of pediatric clinical pathology tests including, metabolic disease screens, hemoglobin electrophoresis, flow cytometry of leukemia-lymphoma, cytogenetics of congenital anomalies and pediatric tumors, granulocyte function studies, pediatric blood transfusion. (case.edu)
  • And if what I eat matters - then how does one identify foods which are recommended for Desmoplastic Small Round Cell Tumor and is it the same answer for everyone with the same diagnosis or genetic risk? (addon.life)
  • Radiation is occasionally used to try and prevent tumor recurrence, and chemotherapy is largely ineffective for this diagnosis. (sarctrials.org)
  • When hypoglycemia does occur in such individuals, an uncommon but important diagnosis to consider is non-islet cell tumor hypoglycemia (NICTH). (medscape.com)
  • Juxtaglomerular cell tumours (JGCT), despite their rarity, should be included in the differential diagnosis of secondary hypertension as they consist of a curable cause of hypertension. (bioscientifica.com)
  • Surgery and radiation of the primary tumor site provide the best chance for cure. (sarctrials.org)
  • Ovarian desmoplastic small round cell tumors: Prognosis is poor! (scirp.org)
  • These are rare tumors and symptoms are often misdiagnosed by physicians. (wikipedia.org)
  • citation needed] Because this is a rare tumor, not many family physicians or oncologists are familiar with this disease. (wikipedia.org)
  • Multiple primary tumors at adjacent site are rare. (koreamed.org)
  • Objective: Ruptured anterior cerebral artery (ACA) trunk aneurysms and middle cerebral artery (MCA) trunk aneurysms are rare, and little is known about them. (koreamed.org)
  • Primary hepatic leiomyosarcoma (PHL) is a rare malignant tumor, which originates from smooth muscles. (koreamed.org)
  • Desmoplastic Ameloblastoma (DA) is a rare variant of ameloblastoma, with specific clinical, imaginological and histopathological features. (bvsalud.org)
  • Although, it appears to grow out from primary cells of childhood. (naturalcurefor.com)
  • Pancreatoblastoma is a malignant exocrine pancreatic tumor that is usually present in childhood. (koreamed.org)
  • For the three years he'd have to watch his childhood friend battle a desmoplastic small round cell tumor, Oct. 29, 2016, was as fitting as it got for Nowak. (positivelynaperville.com)
  • Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
  • Medulloblastoma is the most common malignant central nervous system (CNS) tumor of childhood, with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)
  • Tumor cells have hyperchromatic nuclei with increased nuclear/cytoplasmic ratio. (wikipedia.org)
  • Surgical gross room techniques for the evaluation of tumor resections, explant organs, organs removed for non-neoplastic disease, skin specimens, bone specimens, open lung biopsies, endomyocardial biopsies, rectal suction biopsies. (case.edu)
  • To present 10-year outcomes of unique tumor presentation, suggesting a focused algorithm for surgical management and providing deep analysis for factors affecting survival and surgical outcomes. (bvsalud.org)
  • Wide surgical excision is the rule for operable tumors. (msdmanuals.com)
  • All cancers like Desmoplastic Small Round Cell Tumor can be characterized by a unique set of biochemical pathways - the signature pathways of Desmoplastic Small Round Cell Tumor. (addon.life)
  • 1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)
  • Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • Many of these sarcomas have some (but not all) features in common with their bone-tumor equivalents, and each has unique characteristics that must be considered in their treatment. (sarctrials.org)
  • citation needed] On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase. (wikipedia.org)
  • Review of recent reported cases of NICTH identified widespread anatomic locations and varied pathologic diagnoses of tumors associated with paraneoplastic production of IGF-2 causing hypoglycemia. (medscape.com)
  • When compared with MFBC, MCBC showed higher pathologic tumor size (p (bvsalud.org)
  • These tumors metastasize (spread) very, very rarely. (sarctrials.org)
  • These tumors only rarely (less than 2%) travel to the lungs, even many years after removal of the initial tumor. (sarctrials.org)
  • Brain Tumor Res Treat. (koreamed.org)
  • Ollie Young passed away from a type of brain tumour called a glioblastoma the day before his sixth birthday. (icr.ac.uk)
  • The tumour spectrum of CMMR-D syndrome includes haematological neoplasias, brain tumours and Lynch syndrome-associated tumours. (bmj.com)
  • [ 4 ] Adult cases are unusual, accounting for less than 1% of brain tumors. (medscape.com)
  • Because of our researchers' studies, doctors around the world have been able to lower the amount of radiation given to children for the past 20 years. (stjude.org)
  • Peritoneal carcinomas are divided into primary and secondary peritoneal tumors. (medscape.com)
  • Primary peritoneal carcinomas originate from the cells lining the peritoneum. (medscape.com)
  • Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. (nih.gov)
  • This tumor typically arises in the skin and must be excised by an appropriate expert, as less extensive resections often end in failure. (sarctrials.org)
  • Biochemical pathways like RAS-RAF Signaling, Angiogenesis, Chromatin Remodeling, Oncogenic Histone Methylation are part of the signature definition of Desmoplastic Small Round Cell Tumor. (addon.life)