The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.
The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.
The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.
Pathological processes of the ear, the hearing, and the equilibrium system of the body.
The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.
Auditory sensory cells of organ of Corti, usually placed in one row medially to the core of spongy bone (the modiolus). Inner hair cells are in fewer numbers than the OUTER AUDITORY HAIR CELLS, and their STEREOCILIA are approximately twice as thick as those of the outer hair cells.
A mobile chain of three small bones (INCUS; MALLEUS; STAPES) in the TYMPANIC CAVITY between the TYMPANIC MEMBRANE and the oval window on the wall of INNER EAR. Sound waves are converted to vibration by the tympanic membrane then transmitted via these ear ossicles to the inner ear.
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
The shell-like structure projects like a little wing (pinna) from the side of the head. Ear auricles collect sound from the environment.
The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.
Fenestra of the cochlea, an opening in the basal wall between the MIDDLE EAR and the INNER EAR, leading to the cochlea. It is closed by a secondary tympanic membrane.
A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR.
An oval semitransparent membrane separating the external EAR CANAL from the tympanic cavity (EAR, MIDDLE). It contains three layers: the skin of the external ear canal; the core of radially and circularly arranged collagen fibers; and the MUCOSA of the middle ear.
Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS).
Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.
The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition.
Distortion or disfigurement of the ear caused by disease or injury after birth.
Inflammation of the middle ear with a clear pale yellow-colored transudate.
Ventilation of the middle ear in the treatment of secretory (serous) OTITIS MEDIA, usually by placement of tubes or grommets which pierce the TYMPANIC MEMBRANE.
Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
The spiral EPITHELIUM containing sensory AUDITORY HAIR CELLS and supporting cells in the cochlea. Organ of Corti, situated on the BASILAR MEMBRANE and overlaid by a gelatinous TECTORIAL MEMBRANE, converts sound-induced mechanical waves to neural impulses to the brain.
An oval, bony chamber of the inner ear, part of the bony labyrinth. It is continuous with bony COCHLEA anteriorly, and SEMICIRCULAR CANALS posteriorly. The vestibule contains two communicating sacs (utricle and saccule) of the balancing apparatus. The oval window on its lateral wall is occupied by the base of the STAPES of the MIDDLE EAR.
A general term for the complete or partial loss of the ability to hear from one or both ears.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Objective tests of middle ear function based on the difficulty (impedance) or ease (admittance) of sound flow through the middle ear. These include static impedance and dynamic impedance (i.e., tympanometry and impedance tests in conjunction with intra-aural muscle reflex elicitation). This term is used also for various components of impedance and admittance (e.g., compliance, conductance, reactance, resistance, susceptance).
One of the three ossicles of the middle ear. It transmits sound vibrations from the INCUS to the internal ear (Ear, Internal see LABYRINTH).
Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
Hearing loss due to interference with the mechanical reception or amplification of sound to the COCHLEA. The interference is in the outer or middle ear involving the EAR CANAL; TYMPANIC MEMBRANE; or EAR OSSICLES.
A gelatinous membrane overlying the acoustic maculae of SACCULE AND UTRICLE. It contains minute crystalline particles (otoliths) of CALCIUM CARBONATE and protein on its outer surface. In response to head movement, the otoliths shift causing distortion of the vestibular hair cells which transduce nerve signals to the BRAIN for interpretation of equilibrium.
A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research.
Three long canals (anterior, posterior, and lateral) of the bony labyrinth. They are set at right angles to each other and are situated posterosuperior to the vestibule of the bony labyrinth (VESTIBULAR LABYRINTH). The semicircular canals have five openings into the vestibule with one shared by the anterior and the posterior canals. Within the canals are the SEMICIRCULAR DUCTS.
Personal devices for protection of the ears from loud or high intensity noise, water, or cold. These include earmuffs and earplugs.
A general term for the complete loss of the ability to hear from both ears.
Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.
Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
The audibility limit of discriminating sound intensity and pitch.
The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Transmission of sound waves through vibration of bones in the SKULL to the inner ear (COCHLEA). By using bone conduction stimulation and by bypassing any OUTER EAR or MIDDLE EAR abnormalities, hearing thresholds of the cochlea can be determined. Bone conduction hearing differs from normal hearing which is based on air conduction stimulation via the EAR CANAL and the TYMPANIC MEMBRANE.
A narrow passageway that connects the upper part of the throat to the TYMPANIC CAVITY.
Cells forming a framework supporting the sensory AUDITORY HAIR CELLS in the organ of Corti. Lateral to the medial inner hair cells, there are inner pillar cells, outer pillar cells, Deiters cells, Hensens cells, Claudius cells, Boettchers cells, and others.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Sensory cells in the acoustic maculae with their apical STEREOCILIA embedded in a gelatinous OTOLITHIC MEMBRANE. These hair cells are stimulated by the movement of otolithic membrane, and impulses are transmitted via the VESTIBULAR NERVE to the BRAIN STEM. Hair cells in the saccule and those in the utricle sense linear acceleration in vertical and horizontal directions, respectively.
The yellow or brown waxy secretions produced by vestigial apocrine sweat glands in the external ear canal.
A layer of stratified EPITHELIUM forming the endolymphatic border of the cochlear duct at the lateral wall of the cochlea. Stria vascularis contains primarily three cell types (marginal, intermediate, and basal), and capillaries. The marginal cells directly facing the ENDOLYMPH are important in producing ion gradients and endochoclear potential.
Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).
Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
The cluster of cells inside a blastocyst. These cells give rise to the embryonic disc and eventual embryo proper. They are pluripotent EMBRYONIC STEM CELLS capable of yielding many but not all cell types in a developing organism.
A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.
Examination of the EAR CANAL and eardrum with an OTOSCOPE.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Measurement of hearing based on the use of pure tones of various frequencies and intensities as auditory stimuli.
The testing of the acuity of the sense of hearing to determine the thresholds of the lowest intensity levels at which an individual can hear a set of tones. The frequencies between 125 and 8000 Hz are used to test air conduction thresholds and the frequencies between 250 and 4000 Hz are used to test bone conduction thresholds.
Conditions that impair the transmission of auditory impulses and information from the level of the ear to the temporal cortices, including the sensorineural pathways.
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A spiral tube that is firmly suspended in the bony shell-shaped part of the cochlea. This ENDOLYMPH-filled cochlear duct begins at the vestibule and makes 2.5 turns around a core of spongy bone (the modiolus) thus dividing the PERILYMPH-filled spiral canal into two channels, the SCALA VESTIBULI and the SCALA TYMPANI.
Use of sound to elicit a response in the nervous system.
The blind pouch at the end of the endolymphatic duct. It is a storage reservoir for excess ENDOLYMPH, formed by the blood vessels in the membranous labyrinth.
Surgery performed on the external, middle, or internal ear.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Acupuncture therapy by inserting needles in the ear. It is used to control pain and for treating various ailments.
The posterior part of the temporal bone. It is a projection of the petrous bone.
The inner portion of a retinal rod or a cone photoreceptor cell, situated between the PHOTORECEPTOR CONNECTING CILIUM and the synapse with the adjacent neurons (RETINAL BIPOLAR CELLS; RETINAL HORIZONTAL CELLS). The inner segment contains the cell body, the nucleus, the mitochondria, and apparatus for protein synthesis.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.
The electric response of the cochlear hair cells to acoustic stimulation.
The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.
The sensory ganglion of the COCHLEAR NERVE. The cells of the spiral ganglion send fibers peripherally to the cochlear hair cells and centrally to the COCHLEAR NUCLEI of the BRAIN STEM.
Fenestra or oval opening on the lateral wall of the vestibular labyrinth adjacent to the MIDDLE EAR. It is located above the cochlear round window and normally covered by the base of the STAPES.
Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.
The lower chamber of the COCHLEA, extending from the round window to the helicotrema (the opening at the apex that connects the PERILYMPH-filled spaces of scala tympani and SCALA VESTIBULI).
Mechanosensing organelles of hair cells which respond to fluid motion or fluid pressure changes. They have various functions in many different animals, but are primarily used in hearing.
NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Pain in the ear.
A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
One of three ossicles of the middle ear. It conducts sound vibrations from the MALLEUS to the STAPES.
Inflammation of the inner ear (LABYRINTH).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Surgical reconstruction of the hearing mechanism of the middle ear, with restoration of the drum membrane to protect the round window from sound pressure, and establishment of ossicular continuity between the tympanic membrane and the oval window. (Dorland, 28th ed.)
The 8th cranial nerve. The vestibulocochlear nerve has a cochlear part (COCHLEAR NERVE) which is concerned with hearing and a vestibular part (VESTIBULAR NERVE) which mediates the sense of balance and head position. The fibers of the cochlear nerve originate from neurons of the SPIRAL GANGLION and project to the cochlear nuclei (COCHLEAR NUCLEUS). The fibers of the vestibular nerve arise from neurons of Scarpa's ganglion and project to the VESTIBULAR NUCLEI.
A paired box transcription factor that is essential for ORGANOGENESIS of the CENTRAL NERVOUS SYSTEM and KIDNEY.
A post-MORULA preimplantation mammalian embryo that develops from a 32-cell stage into a fluid-filled hollow ball of over a hundred cells. A blastocyst has two distinctive tissues. The outer layer of trophoblasts gives rise to extra-embryonic tissues. The inner cell mass gives rise to the embryonic disc and eventual embryo proper.
Part of an ear examination that measures the ability of sound to reach the brain.
Ability to determine the specific location of a sound source.
The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE).
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.
A POU domain factor that activates neuronal cell GENETIC TRANSCRIPTION of GENES encoding NEUROFILAMENT PROTEINS, alpha internexin, and SYNAPTOSOMAL-ASSOCIATED PROTEIN 25. Mutations in the Brn-3c gene have been associated with DEAFNESS.
Elements of limited time intervals, contributing to particular results or situations.
A basement membrane in the cochlea that supports the hair cells of the ORGAN OF CORTI, consisting keratin-like fibrils. It stretches from the SPIRAL LAMINA to the basilar crest. The movement of fluid in the cochlea, induced by sound, causes displacement of the basilar membrane and subsequent stimulation of the attached hair cells which transform the mechanical signal into neural activity.
Partial or complete hearing loss in one ear.
A fibroblast growth factor that is expressed primarily during development.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
Procedures for recognizing individual animals and certain identifiable characteristics pertaining to them; includes computerized methods, ear tags, etc.
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
The study of hearing and hearing impairment.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.
Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.
Any sound which is unwanted or interferes with HEARING other sounds.
Inbred C57BL mice are a strain of laboratory mice that have been produced by many generations of brother-sister matings, resulting in a high degree of genetic uniformity and homozygosity, making them widely used for biomedical research, including studies on genetics, immunology, cancer, and neuroscience.
Inflammation of the middle ear with purulent discharge.
Wearable sound-amplifying devices that are intended to compensate for impaired hearing. These generic devices include air-conduction hearing aids and bone-conduction hearing aids. (UMDNS, 1999)
Surgery performed in which part of the STAPES, a bone in the middle ear, is removed and a prosthesis is placed to help transmit sound between the middle ear and inner ear.
Tests for central hearing disorders based on the competing message technique (binaural separation).
Transport proteins that carry specific substances in the blood or across cell membranes.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
The various filaments, granules, tubules or other inclusions within mitochondria.
Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.
Surgical insertion of an electronic hearing device (COCHLEAR IMPLANTS) with electrodes to the COCHLEAR NERVE in the inner ear to create sound sensation in patients with residual nerve fibers.
Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.
A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous COCHLEAR DUCT to the bony spiral canal of the COCHLEA. Its spiral ligament fibrocytes function in conjunction with the STRIA VASCULARIS to mediate cochlear ion homeostasis.
Partial hearing loss in both ears.
Neurons of the innermost layer of the retina, the internal plexiform layer. They are of variable sizes and shapes, and their axons project via the OPTIC NERVE to the brain. A small subset of these cells act as photoreceptors with projections to the SUPRACHIASMATIC NUCLEUS, the center for regulating CIRCADIAN RHYTHM.
A tiny muscle that arises from the posterior wall of the TYMPANIC CAVITY of MIDDLE EAR with its tendon inserted onto the neck of the STAPES. Stapedius pulls the stapes posteriorly and controls its movement.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An implant used to replace one or more of the ear ossicles. They are usually made of plastic, Gelfoam, ceramic, or stainless steel.
Proteins found in any species of bacterium.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray's Anatomy, 30th American ed, p1328, 1332)
Mice bearing mutant genes which are phenotypically expressed in the animals.
The process whereby auditory stimuli are selected, organized, and interpreted by the organism.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
Recording of electric potentials in the retina after stimulation by light.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
Electronic hearing devices typically used for patients with normal outer and middle ear function, but defective inner ear function. In the COCHLEA, the hair cells (HAIR CELLS, VESTIBULAR) may be absent or damaged but there are residual nerve fibers. The device electrically stimulates the COCHLEAR NERVE to create sound sensation.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis to power a variety of cellular functions. Dyneins fall into two major classes based upon structural and functional criteria.
A small bony canal linking the vestibule of the inner ear to the posterior part of the internal surface of the petrous TEMPORAL BONE. It transmits the endolymphatic duct and two small blood vessels.
A continuing periodic change in displacement with respect to a fixed reference. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Specialized cells that detect and transduce light. They are classified into two types based on their light reception structure, the ciliary photoreceptors and the rhabdomeric photoreceptors with MICROVILLI. Ciliary photoreceptor cells use OPSINS that activate a PHOSPHODIESTERASE phosphodiesterase cascade. Rhabdomeric photoreceptor cells use opsins that activate a PHOSPHOLIPASE C cascade.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
I'm sorry for any confusion, but "London" is a place name and not a medical term, so it doesn't have a medical definition. It's the capital city of England and the United Kingdom, known for its rich history, culture, and landmarks. If you have any questions related to health or medicine, I'd be happy to help answer those!
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
Refers to animals in the period of time just after birth.
Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.
The branch of physics that deals with sound and sound waves. In medicine it is often applied in procedures in speech and hearing studies. With regard to the environment, it refers to the characteristics of a room, auditorium, theatre, building, etc. that determines the audibility or fidelity of sounds in it. (From Random House Unabridged Dictionary, 2d ed)
Pathological processes of the VESTIBULOCOCHLEAR NERVE, including the branches of COCHLEAR NERVE and VESTIBULAR NERVE. Common examples are VESTIBULAR NEURITIS, cochlear neuritis, and ACOUSTIC NEUROMA. Clinical signs are varying degree of HEARING LOSS; VERTIGO; and TINNITUS.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.
Proteins obtained from ESCHERICHIA COLI.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
The three membranous semicircular ducts within the bony semicircular canals. They open into the UTRICLE through five openings. Each duct has at one end a sensory area called the ampullary crest. AMPULLARY HAIR CELLS of the crests sense the movement of ENDOLYMPH resulting from rotation of the head.
Aquatic vertebrate sensory system in fish and amphibians. It is composed of sense organs (canal organs and pit organs) containing neuromasts (MECHANORECEPTORS) that detect water displacement caused by moving objects.
A fine channel that passes through the TEMPORAL BONE near the SCALA TYMPANI (the basilar turn of the cochlea). The cochlear aqueduct connects the PERILYMPH-filled bony labyrinth to the SUBARACHNOID SPACE.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The rate dynamics in chemical or physical systems.
Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The physiological renewal, repair, or replacement of tissue.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Intra-aural contraction of tensor tympani and stapedius in response to sound.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
Retinal diseases refer to a diverse group of vision-threatening disorders that affect the retina's structure and function, including age-related macular degeneration, diabetic retinopathy, retinal detachment, retinitis pigmentosa, and macular edema, among others.
'Nerve tissue proteins' are specialized proteins found within the nervous system's biological tissue, including neurofilaments, neuronal cytoskeletal proteins, and neural cell adhesion molecules, which facilitate structural support, intracellular communication, and synaptic connectivity essential for proper neurological function.
A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. (1/1036)

Potassium channels regulate electrical signaling and the ionic composition of biological fluids. Mutations in the three known genes of the KCNQ branch of the K+ channel gene family underlie inherited cardiac arrhythmias (in some cases associated with deafness) and neonatal epilepsy. We have now cloned KCNQ4, a novel member of this branch. It maps to the DFNA2 locus for a form of nonsyndromic dominant deafness. In the cochlea, it is expressed in sensory outer hair cells. A mutation in this gene in a DFNA2 pedigree changes a residue in the KCNQ4 pore region. It abolishes the potassium currents of wild-type KCNQ4 on which it exerts a strong dominant-negative effect. Whereas mutations in KCNQ1 cause deafness by affecting endolymph secretion, the mechanism leading to KCNQ4-related hearing loss is intrinsic to outer hair cells.  (+info)

3D MRI of the membranous labyrinth. An age related comparison of MR findings in patients with labyrinthine fibrosis and in persons without inner ear symptoms. (2/1036)

PURPOSE: We compared MRI of the membranous labyrinth in patients with chronic non-neoplastic inner ear disease and MR signs of labyrinthine fibrosis and controls depending on their age, in order to establish whether there were any MR differences regarding patient age groups, control age groups and between the patients and controls themselves. MATERIALS AND METHODS: Clinical ENT examinations as well as a T2* weighted 3D CISS (Constructive Interference in Steady State) sequence with a slice thickness of 0.7 mm were performed. Our collective was subdivided as follows: 0-19 years (10 controls, 3 patients with chronic non-neoplastic inner ear disease), 20-49 years (55 controls, 8 patients), 50 years and older (40 controls, 22 patients). Detectability of labyrinthine structures (e.g. cochlea, vestibule, semicircular canals) and filling defects were evaluated. RESULTS: In the 3 age-groups of the control collective no significant differences were observed in the membranous labyrinth. However differences concerning labyrinthine detectability emerged between controls and patients in both the 20-49 years and 50 years and older age groups. In the patient collective the 3 age groups showed no significant discrepancy in the mean number of lesions. CONCLUSION: Filling defects of the membranous labyrinth on 3D CISS MR images are pathological even in older persons. We would therefore recommend high resolution T2* weighted MRI in the case of suspected labyrinthine fibrosis.  (+info)

CT and MR findings of Michel anomaly: inner ear aplasia. (3/1036)

In 1863, Michel described a condition characterized by a total absence of differentiated inner ear structures associated with other skull base anomalies, including an abnormal course of the facial nerve and jugular veins. Michel aplasia clearly differs from Michel dysplasia, in which arrest of embryologic development occurs later. Recently, the role of otic capsule formation on mesenchymal differentiation was reported as well as the impact of the genetic deletion of the homeobox gene on the development of the ear, cranial nerves, and hindbrain. We report two patients with a total absence of inner ear structures bilaterally, illustrating the characteristic appearance of Michel aplasia and associated skull base anomalies.  (+info)

Characterization of ootolith soluble-matrix producing cells in the saccular epithelium of rainbow trout (Oncorhynchus mykiss) inner ear. (4/1036)

Although the organic matrix may play an important role in the growth of teleost otoliths, cellular contributions to the production of the organic matrix have been studied in only a small number of teleost species with limited methods, and are still poorly understood. In order to characterize saccular epithelial cells which produce otolith matrix, antiserum was raised against an EDTA-soluble fraction of otolith matrix (otolith soluble-matrix, OSM) of the rainbow trout. The components in the OSM and in the endolymph were characterized by immunoblotting. The saccular epithelium was immunohistochemically stained with the antiserum and the ultrastructure of OSM immunoreactive cells was studied. By immunoblotting, multiple components (> 94.0 kDa [smeared] and 43.0 kDa) in the OSM reacted with the antiserum, whereas only one band (> 94.0 kDa) was detected in the endolymph. Under immunohistochemical staining, reactions to the antiserum were observed in columnar cells lined at the most peripheral region of the sensory epithelium, transitional epithelial cells, and squamous epithelial cells. Electron microscopic observations revealed that all three types of cells were equipped with extended rough endoplasmic reticulum and prominent Golgi apparatus, suggesting the active production of organic material(s). Dilations of translucent vesicles, apocrine-like extrusions of cytoplasm, and vesicles containing many minute globules were frequently associated with the apical surface of these cells. Some ruptured vesicles were observed, releasing their contents into the endolymphatic space. The present study identified columnar cells lining the most peripheral region of the sensory epithelium, transitional epithelial cells, and squamous epithelial cells as the OSM-producing cells. We suggest that the OSM components are secreted and dissolved into the endolymph and subsequently deposited onto the otolith.  (+info)

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. (5/1036)

The Otx1 and Otx2 genes are two murine orthologues of the Orthodenticle (Otd) gene in Drosophila. In the developing mouse embryo, both Otx genes are expressed in the rostral head region and in certain sense organs such as the inner ear. Previous studies have shown that mice lacking Otx1 display abnormal patterning of the brain, whereas embryos lacking Otx2 develop without heads. In this study, we examined, at different developmental stages, the inner ears of mice lacking both Otx1 and Otx2 genes. In wild-type inner ears, Otx1, but not Otx2, was expressed in the lateral canal and ampulla, as well as part of the utricle. Ventral to the mid-level of the presumptive utricle, Otx1 and Otx2 were co-expressed, in regions such as the saccule and cochlea. Paint-filled membranous labyrinths of Otx1-/- mutants showed an absence of the lateral semicircular canal, lateral ampulla, utriculosaccular duct and cochleosaccular duct, and a poorly defined hook (the proximal part) of the cochlea. Defects in the shape of the saccule and cochlea were variable in Otx1-/- mice and were much more severe in an Otx1-/-;Otx2(+/)- background. Histological and in situ hybridization experiments of both Otx1-/- and Otx1-/-;Otx2(+/)- mutants revealed that the lateral crista was absent. In addition, the maculae of the utricle and saccule were partially fused. In mutant mice in which both copies of the Otx1 gene were replaced with a human Otx2 cDNA (hOtx2(1)/ hOtx2(1)), most of the defects associated with Otx1-/- mutants were rescued. However, within the inner ear, hOtx2 expression failed to rescue the lateral canal and ampulla phenotypes, and only variable rescues were observed in regions where both Otx1 and Otx2 are normally expressed. These results suggest that both Otx genes play important and differing roles in the morphogenesis of the mouse inner ear and the development of its sensory organs.  (+info)

Math1: an essential gene for the generation of inner ear hair cells. (6/1036)

The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.  (+info)

Lesion-induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation. (7/1036)

1. We have recently shown that neurones in the rostral region of the medial vestibular nucleus (MVN) develop a sustained increase in their intrinsic excitability within 4 h of a lesion of the vestibular receptors of the ipsilateral inner ear. This increased excitability may be important in the rapid recovery of resting activity in these neurones during 'vestibular compensation', the behavioural recovery that follows unilateral vestibular deafferentation. In this study we investigated the role of the acute stress that normally accompanies the symptoms of unilateral labyrinthectomy (UL), and in particular the role of glucocorticoid receptors (GRs), in the development of the increase in excitability in the rostral MVN cells after UL in the rat. 2. The compensatory increase in intrinsic excitability (CIE) of MVN neurones failed to occur in animals that were labyrinthectomized under urethane anaesthesia and kept at a stable level of anaesthesia for either 4 or 6 h after UL, so that they did not experience the stress normally associated with the vestibular deafferentation syndrome. In these animals, 'mimicking' the stress response by administration of the synthetic GR agonist dexamethasone at the time of UL, restored and somewhat potentiated CIE in the MVN cells. Administration of dexamethasone in itself had no effect on the intrinsic excitability of MVN cells in sham-operated animals. 3. In animals that awoke after labyrinthectomy, and which therefore experienced the full range of oculomotor and postural symptoms of UL, there was a high level of Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus over 1.5-3 h post-UL, indicating a strong activation of the stress axis. 4. The GR antagonist RU38486 administered at the time of UL abolished CIE in the rostral MVN cells, and significantly delayed behavioural recovery as indicated by the persistence of circular walking. The mineralocorticoid receptor (MR) antagonist spironolactone administered at the time of UL had no effect. 5. Vestibular compensation thus involves a novel form of 'metaplasticity' in the adult brain, in which the increase in intrinsic excitability of rostral MVN cells and the initial behavioural recovery are dependent both on the vestibular deafferentation and on the activation of glucocorticoid receptors, during the acute behavioural stress response that follows UL. These findings help elucidate the beneficial effects of neuroactive steroids on vestibular plasticity in various species including man, while the lack of such an effect in the guinea-pig may be due to the significant differences in the physiology of the stress axis in that species.  (+info)

Inner ear damage in guinea pigs exposed to stable and impulse noise. (8/1036)

OBJECTIVE: To investigate the inner ear damage after exposure to stable noise, impulse noise and stable plus impulse noise in guinea pigs. METHODS: Ninety-six healthy guinea pigs were divided into 3 equal groups. (1) Stable noise group: exposed to 110 dBA stable noise for 3 days, 4 hours per day. (2) Impulse noise group: exposed to 165 dBA simulated cannon fire impulse noise 10 times successively at an interval of 10 seconds. (3) stable plus impulse noise group: exposed to the same stable noise as that in the first group, then after a 2-hour rest, the animals were followed with impulse noise exposures as that in the second group. After those exposure, each of the 3 groups was further divided into 4 subgroups according to the time after the noise exposure, namely, the right after, 7 d, 14 d and 30 d groups. The evoked cortical potential responses to click and tone burst stimulation sound were examined. The surface preparation and celloidine embedded serial section of the cochlea were observed under a light microscope. RESULTS: Both the stable and impulse noise could increase the hearing threshold and damage the inner ear hair cells. The damage in the first group was relatively slight, whereas in group 3 the damage was more severe than that in the other 2 groups. CONCLUSION: For seamen who are working in heavy noise environment, corresponding measures should be taken to protect their ears from noise which induces hearing loss.  (+info)

The ear is the sensory organ responsible for hearing and maintaining balance. It can be divided into three parts: the outer ear, middle ear, and inner ear. The outer ear consists of the pinna (the visible part of the ear) and the external auditory canal, which directs sound waves toward the eardrum. The middle ear contains three small bones called ossicles that transmit sound vibrations from the eardrum to the inner ear. The inner ear contains the cochlea, a spiral-shaped organ responsible for converting sound vibrations into electrical signals that are sent to the brain, and the vestibular system, which is responsible for maintaining balance.

The inner ear is the innermost part of the ear that contains the sensory organs for hearing and balance. It consists of a complex system of fluid-filled tubes and sacs called the vestibular system, which is responsible for maintaining balance and spatial orientation, and the cochlea, a spiral-shaped organ that converts sound vibrations into electrical signals that are sent to the brain.

The inner ear is located deep within the temporal bone of the skull and is protected by a bony labyrinth. The vestibular system includes the semicircular canals, which detect rotational movements of the head, and the otolith organs (the saccule and utricle), which detect linear acceleration and gravity.

Damage to the inner ear can result in hearing loss, tinnitus (ringing in the ears), vertigo (a spinning sensation), and balance problems.

The middle ear is the middle of the three parts of the ear, located between the outer ear and inner ear. It contains three small bones called ossicles (the malleus, incus, and stapes) that transmit and amplify sound vibrations from the eardrum to the inner ear. The middle ear also contains the Eustachian tube, which helps regulate air pressure in the middle ear and protects against infection by allowing fluid to drain from the middle ear into the back of the throat.

The external ear is the visible portion of the ear that resides outside of the head. It consists of two main structures: the pinna or auricle, which is the cartilaginous structure that people commonly refer to as the "ear," and the external auditory canal, which is the tubular passageway that leads to the eardrum (tympanic membrane).

The primary function of the external ear is to collect and direct sound waves into the middle and inner ear, where they can be converted into neural signals and transmitted to the brain for processing. The external ear also helps protect the middle and inner ear from damage by foreign objects and excessive noise.

Ear diseases are medical conditions that affect the ear and its various components, including the outer ear, middle ear, and inner ear. These diseases can cause a range of symptoms, such as hearing loss, tinnitus (ringing in the ears), vertigo (dizziness), ear pain, and discharge. Some common ear diseases include:

1. Otitis externa (swimmer's ear) - an infection or inflammation of the outer ear and ear canal.
2. Otitis media - an infection or inflammation of the middle ear, often caused by a cold or flu.
3. Cholesteatoma - a skin growth that develops in the middle ear behind the eardrum.
4. Meniere's disease - a disorder of the inner ear that can cause vertigo, hearing loss, and tinnitus.
5. Temporomandibular joint (TMJ) disorders - problems with the joint that connects the jawbone to the skull, which can cause ear pain and other symptoms.
6. Acoustic neuroma - a noncancerous tumor that grows on the nerve that connects the inner ear to the brain.
7. Presbycusis - age-related hearing loss.

Treatment for ear diseases varies depending on the specific condition and its severity. It may include medication, surgery, or other therapies. If you are experiencing symptoms of an ear disease, it is important to seek medical attention from a healthcare professional, such as an otolaryngologist (ear, nose, and throat specialist).

The ear canal, also known as the external auditory canal, is the tubular passage that extends from the outer ear (pinna) to the eardrum (tympanic membrane). It is lined with skin and tiny hairs, and is responsible for conducting sound waves from the outside environment to the middle and inner ear. The ear canal is typically about 2.5 cm long in adults and has a self-cleaning mechanism that helps to keep it free of debris and wax.

Auditory inner hair cells are specialized sensory receptor cells located in the inner ear, more specifically in the organ of Corti within the cochlea. They play a crucial role in hearing by converting mechanical sound energy into electrical signals that can be processed and interpreted by the brain.

Human ears have about 3,500 inner hair cells arranged in one row along the length of the basilar membrane in each cochlea. These hair cells are characterized by their stereocilia, which are hair-like projections on the apical surface that are embedded in a gelatinous matrix called the tectorial membrane.

When sound waves cause the basilar membrane to vibrate, the stereocilia of inner hair cells bend and deflect. This deflection triggers a cascade of biochemical events leading to the release of neurotransmitters at the base of the hair cell. These neurotransmitters then stimulate the afferent auditory nerve fibers (type I fibers) that synapse with the inner hair cells, transmitting the electrical signals to the brain for further processing and interpretation as sound.

Damage or loss of these inner hair cells can lead to significant hearing impairment or deafness, as they are essential for normal auditory function. Currently, there is no effective way to regenerate damaged inner hair cells in humans, making hearing loss due to their damage permanent.

The ear ossicles are the three smallest bones in the human body, which are located in the middle ear. They play a crucial role in the process of hearing by transmitting and amplifying sound vibrations from the eardrum to the inner ear. The three ear ossicles are:

1. Malleus (hammer): The largest of the three bones, it is shaped like a hammer and connects to the eardrum.
2. Incus (anvil): The middle-sized bone, it looks like an anvil and connects the malleus to the stapes.
3. Stapes (stirrup): The smallest and lightest bone in the human body, it resembles a stirrup and transmits vibrations from the incus to the inner ear.

Together, these tiny bones work to efficiently transfer sound waves from the air to the fluid-filled cochlea of the inner ear, enabling us to hear.

Ear neoplasms refer to abnormal growths or tumors that occur in the ear. These growths can be benign (non-cancerous) or malignant (cancerous) and can affect any part of the ear, including the outer ear, middle ear, inner ear, and the ear canal.

Benign ear neoplasms are typically slow-growing and do not spread to other parts of the body. Examples include exostoses, osteomas, and ceruminous adenomas. These types of growths are usually removed surgically for cosmetic reasons or if they cause discomfort or hearing problems.

Malignant ear neoplasms, on the other hand, can be aggressive and may spread to other parts of the body. Examples include squamous cell carcinoma, basal cell carcinoma, and adenoid cystic carcinoma. These types of tumors often require more extensive treatment, such as surgery, radiation therapy, and chemotherapy.

It is important to note that any new growth or change in the ear should be evaluated by a healthcare professional to determine the nature of the growth and develop an appropriate treatment plan.

The ear auricle, also known as the pinna or outer ear, is the visible external structure of the ear that serves to collect and direct sound waves into the ear canal. It is composed of cartilage and skin and is shaped like a curved funnel. The ear auricle consists of several parts including the helix (the outer rim), antihelix (the inner curved prominence), tragus and antitragus (the small pointed eminences in front of and behind the ear canal opening), concha (the bowl-shaped area that directs sound into the ear canal), and lobule (the fleshy lower part hanging from the ear).

The cochlea is a part of the inner ear that is responsible for hearing. It is a spiral-shaped structure that looks like a snail shell and is filled with fluid. The cochlea contains hair cells, which are specialized sensory cells that convert sound vibrations into electrical signals that are sent to the brain.

The cochlea has three main parts: the vestibular canal, the tympanic canal, and the cochlear duct. Sound waves enter the inner ear and cause the fluid in the cochlea to move, which in turn causes the hair cells to bend. This bending motion stimulates the hair cells to generate electrical signals that are sent to the brain via the auditory nerve.

The brain then interprets these signals as sound, allowing us to hear and understand speech, music, and other sounds in our environment. Damage to the hair cells or other structures in the cochlea can lead to hearing loss or deafness.

The round window ( membrana tympani rotunda) is a small, thin membrane-covered opening located in the inner ear between the middle ear and the cochlea. It serves as one of the two openings that lead into the cochlea, with the other being the oval window.

The round window's primary function is to help regulate and dampen the pressure changes within the cochlea that occur when sound waves reach the inner ear. This is accomplished through the movement of the fluid-filled spaces inside the cochlea (the scala vestibuli and scala tympani) caused by vibrations from the stapes bone, which connects to the oval window.

As the stapes bone moves in response to sound waves, it causes a corresponding motion in the perilymph fluid within the cochlea. This movement then creates pressure changes at the round window, causing it to bulge outward or move inward. The flexibility of the round window allows it to absorb and dissipate these pressure changes, which helps protect the delicate structures inside the inner ear from damage due to excessive pressure buildup.

It is important to note that any damage or dysfunction in the round window can negatively impact hearing ability and cause various hearing disorders.

Cholesteatoma, middle ear is a medical condition characterized by the abnormal growth of skin cells (keratinizing squamous epithelium) within the middle ear space. This skin cells accumulation forms a pearly, white, or gray mass that can erode and destroy surrounding structures such as the ossicles (the tiny bones in the middle ear), the mastoid process (a bony prominence behind the ear), and even the inner ear or brain.

Cholesteatomas can be congenital (present at birth) or acquired (develop later in life). Acquired cholesteatomas are more common and usually result from repeated middle ear infections that cause a retraction pocket of the eardrum, which then traps skin cells leading to their abnormal growth. Symptoms of cholesteatoma may include hearing loss, ear drainage, ear pain, vertigo, or facial weakness. Treatment typically involves surgical removal of the cholesteatoma and restoration of any damaged structures.

The tympanic membrane, also known as the eardrum, is a thin, cone-shaped membrane that separates the external auditory canal from the middle ear. It serves to transmit sound vibrations from the air to the inner ear, where they are converted into electrical signals that can be interpreted by the brain as sound. The tympanic membrane is composed of three layers: an outer layer of skin, a middle layer of connective tissue, and an inner layer of mucous membrane. It is held in place by several small bones and muscles and is highly sensitive to changes in pressure.

Labyrinth diseases refer to conditions that affect the inner ear's labyrinth, which is the complex system of fluid-filled channels and sacs responsible for maintaining balance and hearing. These diseases can cause symptoms such as vertigo (a spinning sensation), dizziness, nausea, hearing loss, and tinnitus (ringing in the ears). Examples of labyrinth diseases include Meniere's disease, labyrinthitis, vestibular neuronitis, and benign paroxysmal positional vertigo. Treatment for these conditions varies depending on the specific diagnosis but may include medications, physical therapy, or surgery.

Ear cartilage, also known as auricular cartilage, refers to the flexible connective tissue that makes up the structural framework of the external ear or pinna. The ear cartilage provides support and shape to the ear, helping to direct sound waves into the ear canal and towards the eardrum.

The ear cartilage is composed of type II collagen fibers and proteoglycans, which give it its flexibility and resiliency. It is covered by a thin layer of skin on both sides and contains no bones. Instead, the ear cartilage is shaped and maintained by the surrounding muscles and connective tissue.

There are three main parts of the ear cartilage: the helix, the antihelix, and the tragus. The helix is the outer rim of the ear, while the antihelix is the curved ridge that runs parallel to the helix. The tragus is the small piece of cartilage that projects from the front of the ear canal.

Ear cartilage can be affected by various conditions, including trauma, infection, and degenerative changes associated with aging. In some cases, surgical procedures may be required to reshape or reconstruct damaged ear cartilage.

Hearing is the ability to perceive sounds by detecting vibrations in the air or other mediums and translating them into nerve impulses that are sent to the brain for interpretation. In medical terms, hearing is defined as the sense of sound perception, which is mediated by the ear and interpreted by the brain. It involves a complex series of processes, including the conduction of sound waves through the outer ear to the eardrum, the vibration of the middle ear bones, and the movement of fluid in the inner ear, which stimulates hair cells to send electrical signals to the auditory nerve and ultimately to the brain. Hearing allows us to communicate with others, appreciate music and sounds, and detect danger or important events in our environment.

Acquired ear deformities refer to abnormal shapes or structures of the ear that result from injury, infection, inflammation, or other external factors after birth. These deformities can affect the appearance and function of the ear, causing symptoms such as hearing loss or discomfort. Examples of acquired ear deformities include:

1. Cauliflower ear: a condition characterized by swelling, thickening, and distortion of the ear caused by repeated trauma or injury to the ear cartilage.
2. Microtia: a congenital ear abnormality that can become worse over time due to infection, inflammation, or trauma, resulting in an underdeveloped or absent ear.
3. Macrotia: an abnormally large ear that may result from injury or other external factors.
4. Stenosis: a narrowing of the ear canal that can result from chronic inflammation, infection, or scarring.
5. Hematoma: a collection of blood in the ear tissue caused by trauma or injury, which can lead to deformity if not treated promptly.
6. Keloids: overgrowths of scar tissue that can form after injury or surgery and distort the shape of the ear.

Treatment for acquired ear deformities may include surgical reconstruction, splinting, or other interventions depending on the severity and underlying cause of the condition.

Otitis media with effusion (OME), also known as serous otitis media or glue ear, is a medical condition characterized by the presence of fluid in the middle ear without signs or symptoms of acute ear infection. The fluid accumulation occurs due to the dysfunction of the Eustachian tube, which results in negative pressure and subsequent accumulation of sterile fluid within the middle ear space.

OME can lead to hearing difficulties, especially in children, as the fluid buildup impairs sound conduction through the ossicles in the middle ear. Symptoms may include mild hearing loss, tinnitus (ringing in the ears), and a sensation of fullness or pressure in the affected ear. In some cases, OME can resolve on its own within a few weeks or months; however, persistent cases might require medical intervention, such as placement of tympanostomy tubes (ear tubes) to drain the fluid and restore hearing.

Middle ear ventilation refers to the normal process of air movement between the middle ear and the back of the nose (nasopharynx) through the eustachian tube. This tube is a narrow canal that connects the middle ear to the nasopharynx and helps to regulate air pressure in the middle ear, preventing its accumulation and subsequent negative pressure or fluid build-up, which can lead to conditions such as otitis media (middle ear infection) or serous otitis media (fluid in the middle ear).

The eustachian tube opens during activities such as swallowing, yawning, or chewing, allowing fresh air to enter the middle ear and any accumulated fluid or gas to be drained out. Abnormalities in middle ear ventilation can result from dysfunction of the eustachian tube, leading to various middle ear disorders.

Otitis media is an inflammation or infection of the middle ear. It can occur as a result of a cold, respiratory infection, or allergy that causes fluid buildup behind the eardrum. The buildup of fluid can lead to infection and irritation of the middle ear, causing symptoms such as ear pain, hearing loss, and difficulty balancing. There are two types of otitis media: acute otitis media (AOM), which is a short-term infection that can cause fever and severe ear pain, and otitis media with effusion (OME), which is fluid buildup in the middle ear without symptoms of infection. In some cases, otitis media may require medical treatment, including antibiotics or the placement of ear tubes to drain the fluid and relieve pressure on the eardrum.

The Organ of Corti is the sensory organ of hearing within the cochlea of the inner ear. It is a structure in the inner spiral sulcus of the cochlear duct and is responsible for converting sound vibrations into electrical signals that are sent to the brain via the auditory nerve.

The Organ of Corti consists of hair cells, which are sensory receptors with hair-like projections called stereocilia on their apical surfaces. These stereocilia are embedded in a gelatinous matrix and are arranged in rows of different heights. When sound vibrations cause the fluid in the cochlea to move, the stereocilia bend, which opens ion channels and triggers nerve impulses that are sent to the brain.

Damage or loss of hair cells in the Organ of Corti can result in hearing loss, making it a critical structure for maintaining normal auditory function.

The vestibular system is a part of the inner ear that contributes to our sense of balance and spatial orientation. It is made up of two main components: the vestibule and the labyrinth.

The vestibule is a bony chamber in the inner ear that contains two important structures called the utricle and saccule. These structures contain hair cells and fluid-filled sacs that help detect changes in head position and movement, allowing us to maintain our balance and orientation in space.

The labyrinth, on the other hand, is a more complex structure that includes the vestibule as well as three semicircular canals. These canals are also filled with fluid and contain hair cells that detect rotational movements of the head. Together, the vestibule and labyrinth work together to provide us with information about our body's position and movement in space.

Overall, the vestibular system plays a crucial role in maintaining our balance, coordinating our movements, and helping us navigate through our environment.

Hearing loss is a partial or total inability to hear sounds in one or both ears. It can occur due to damage to the structures of the ear, including the outer ear, middle ear, inner ear, or nerve pathways that transmit sound to the brain. The degree of hearing loss can vary from mild (difficulty hearing soft sounds) to severe (inability to hear even loud sounds). Hearing loss can be temporary or permanent and may be caused by factors such as exposure to loud noises, genetics, aging, infections, trauma, or certain medical conditions. It is important to note that hearing loss can have significant impacts on a person's communication abilities, social interactions, and overall quality of life.

The temporal bone is a paired bone that is located on each side of the skull, forming part of the lateral and inferior walls of the cranial cavity. It is one of the most complex bones in the human body and has several important structures associated with it. The main functions of the temporal bone include protecting the middle and inner ear, providing attachment for various muscles of the head and neck, and forming part of the base of the skull.

The temporal bone is divided into several parts, including the squamous part, the petrous part, the tympanic part, and the styloid process. The squamous part forms the lateral portion of the temporal bone and articulates with the parietal bone. The petrous part is the most medial and superior portion of the temporal bone and contains the inner ear and the semicircular canals. The tympanic part forms the lower and anterior portions of the temporal bone and includes the external auditory meatus or ear canal. The styloid process is a long, slender projection that extends downward from the inferior aspect of the temporal bone and serves as an attachment site for various muscles and ligaments.

The temporal bone plays a crucial role in hearing and balance, as it contains the structures of the middle and inner ear, including the oval window, round window, cochlea, vestibule, and semicircular canals. The stapes bone, one of the three bones in the middle ear, is entirely encased within the petrous portion of the temporal bone. Additionally, the temporal bone contains important structures for facial expression and sensation, including the facial nerve, which exits the skull through the stylomastoid foramen, a small opening in the temporal bone.

Acoustic impedance tests are diagnostic procedures used to measure the impedance or resistance of various parts of the ear to sound waves. These tests are often used to assess hearing function and diagnose any issues related to the middle ear, such as fluid buildup or problems with the eardrum.

The most common type of acoustic impedance test is tympanometry, which measures the mobility of the eardrum and the middle ear system by creating variations in air pressure within the ear canal. During this test, a small probe is inserted into the ear canal, and sound waves are generated while the pressure is varied. The resulting measurements provide information about the condition of the middle ear and can help identify any issues that may be affecting hearing.

Another type of acoustic impedance test is acoustic reflex testing, which measures the body's natural response to loud sounds. This involves measuring the contraction of the stapedius muscle in the middle ear, which occurs in response to loud noises. By measuring the strength and timing of this reflex, audiologists can gain additional insights into the functioning of the middle ear and identify any abnormalities that may be present.

Overall, acoustic impedance tests are important tools for diagnosing hearing problems and identifying any underlying issues in the middle ear. They are often used in conjunction with other hearing tests to provide a comprehensive assessment of an individual's hearing function.

The stapes is the smallest bone in the human body, which is a part of the middle ear. It is also known as the "stirrup" because of its U-shaped structure. The stapes connects the inner ear to the middle ear, transmitting sound vibrations from the ear drum to the inner ear. More specifically, it is the third bone in the series of three bones (the ossicles) that conduct sound waves from the air to the fluid-filled inner ear.

Sensorineural hearing loss (SNHL) is a type of hearing impairment that occurs due to damage to the inner ear (cochlea) or to the nerve pathways from the inner ear to the brain. It can be caused by various factors such as aging, exposure to loud noises, genetics, certain medical conditions (like diabetes and heart disease), and ototoxic medications.

SNHL affects the ability of the hair cells in the cochlea to convert sound waves into electrical signals that are sent to the brain via the auditory nerve. As a result, sounds may be perceived as muffled, faint, or distorted, making it difficult to understand speech, especially in noisy environments.

SNHL is typically permanent and cannot be corrected with medication or surgery, but hearing aids or cochlear implants can help improve communication and quality of life for those affected.

The endolymphatic duct is a narrow canal in the inner ear that is part of the membranous labyrinth. It connects the utricle and saccule (two sensory structures in the vestibular system responsible for detecting changes in head position and movement) to the endolymphatic sac (a dilated portion of the duct that helps regulate the volume and pressure of endolymph, a fluid found within the membranous labyrinth).

The endolymphatic duct plays a crucial role in maintaining the balance and homeostasis of the inner ear by allowing the absorption and circulation of endolymph. Disorders or abnormalities in this region can lead to various vestibular and hearing dysfunctions, such as Meniere's disease, endolymphatic hydrops, and other inner ear disorders.

The kidney medulla is the inner portion of the renal pyramids in the kidney, consisting of multiple conical structures found within the kidney. It is composed of loops of Henle and collecting ducts responsible for concentrating urine by reabsorbing water and producing a hyperosmotic environment. The kidney medulla has a unique blood supply and is divided into an inner and outer zone, with the inner zone having a higher osmolarity than the outer zone. This region of the kidney helps regulate electrolyte and fluid balance in the body.

Conductive hearing loss is a type of hearing loss that occurs when there is a problem with the outer or middle ear. Sound waves are not able to transmit efficiently through the ear canal to the eardrum and the small bones in the middle ear, resulting in a reduction of sound that reaches the inner ear. Causes of conductive hearing loss may include earwax buildup, fluid in the middle ear, a middle ear infection, a hole in the eardrum, or problems with the tiny bones in the middle ear. This type of hearing loss can often be treated through medical intervention or surgery.

The otolithic membrane is a part of the inner ear's vestibular system, which contributes to our sense of balance and spatial orientation. It is composed of a gelatinous material containing tiny calcium carbonate crystals called otoconia or otoliths. These crystals provide weight to the membrane, allowing it to detect linear acceleration and gravity-induced head movements.

There are two otolithic membranes in each inner ear, located within the utricle and saccule, two of the three main vestibular organs. The utricle is primarily responsible for detecting horizontal movement and head tilts, while the saccule senses vertical motion and linear acceleration.

Damage to the otolithic membrane can result in balance disorders, vertigo, or dizziness.

## I am not aware of a medical definition for the term "chinchilla."

A chinchilla is actually a type of rodent that is native to South America. They have thick, soft fur and are often kept as exotic pets or used in laboratory research. If you're looking for information about chinchillas in a medical context, such as their use in research or any potential health concerns related to keeping them as pets, I would be happy to help you try to find more information on those topics.

The semicircular canals are part of the vestibular system in the inner ear that contributes to the sense of balance and spatial orientation. They are composed of three fluid-filled tubes, each located in a different plane (anterior, posterior, and horizontal) and arranged at approximately right angles to each other. The semicircular canals detect rotational movements of the head, enabling us to maintain our equilibrium during movement.

When the head moves, the fluid within the semicircular canals moves in response to that motion. At the end of each canal is a structure called the ampulla, which contains hair cells with hair-like projections (stereocilia) embedded in a gelatinous substance. As the fluid moves, it bends the stereocilia, stimulating the hair cells and sending signals to the brain via the vestibular nerve. The brain then interprets these signals to determine the direction and speed of head movement, allowing us to maintain our balance and orientation in space.

Ear protective devices are types of personal protective equipment designed to protect the ears from potential damage or injury caused by excessive noise or pressure changes. These devices typically come in two main forms: earplugs and earmuffs.

Earplugs are small disposable or reusable plugs that are inserted into the ear canal to block out or reduce loud noises. They can be made of foam, rubber, plastic, or other materials and are available in different sizes to fit various ear shapes and sizes.

Earmuffs, on the other hand, are headbands with cups that cover the entire outer ear. The cups are typically made of sound-absorbing materials such as foam or fluid-filled cushions that help to block out noise. Earmuffs can be used in combination with earplugs for added protection.

Both earplugs and earmuffs are commonly used in industrial settings, construction sites, concerts, shooting ranges, and other noisy environments to prevent hearing loss or damage. It is important to choose the right type of ear protective device based on the level and type of noise exposure, as well as individual comfort and fit.

Deafness is a hearing loss that is so severe that it results in significant difficulty in understanding or comprehending speech, even when using hearing aids. It can be congenital (present at birth) or acquired later in life due to various causes such as disease, injury, infection, exposure to loud noises, or aging. Deafness can range from mild to profound and may affect one ear (unilateral) or both ears (bilateral). In some cases, deafness may be accompanied by tinnitus, which is the perception of ringing or other sounds in the ears.

Deaf individuals often use American Sign Language (ASL) or other forms of sign language to communicate. Some people with less severe hearing loss may benefit from hearing aids, cochlear implants, or other assistive listening devices. Deafness can have significant social, educational, and vocational implications, and early intervention and appropriate support services are critical for optimal development and outcomes.

Spontaneous otoacoustic emissions (SOAEs) are low-level sounds that are produced by the inner ear (cochlea) without any external stimulation. They can be recorded in a quiet room using specialized microphones placed inside the ear canal. SOAEs are thought to arise from the motion of the hair cells within the cochlea, which generate tiny currents in response to sound. These currents then cause the surrounding fluid and tissue to vibrate, producing sound waves that can be detected with a microphone.

SOAEs are typically present in individuals with normal hearing, although their presence or absence is not a definitive indicator of hearing ability. They tend to occur at specific frequencies and can vary from person to person. In some cases, SOAEs may be absent or reduced in individuals with hearing loss or damage to the hair cells in the cochlea.

It's worth noting that SOAEs are different from evoked otoacoustic emissions (EOAEs), which are sounds produced by the inner ear in response to external stimuli, such as clicks or tones. Both types of otoacoustic emissions are used in hearing tests and research to assess cochlear function and health.

Auditory brainstem evoked potentials (ABEPs or BAEPs) are medical tests that measure the electrical activity in the auditory pathway of the brain in response to sound stimulation. The test involves placing electrodes on the scalp and recording the tiny electrical signals generated by the nerve cells in the brainstem as they respond to clicks or tone bursts presented through earphones.

The resulting waveform is analyzed for latency (the time it takes for the signal to travel from the ear to the brain) and amplitude (the strength of the signal). Abnormalities in the waveform can indicate damage to the auditory nerve or brainstem, and are often used in the diagnosis of various neurological conditions such as multiple sclerosis, acoustic neuroma, and brainstem tumors.

The test is non-invasive, painless, and takes only a few minutes to perform. It provides valuable information about the functioning of the auditory pathway and can help guide treatment decisions for patients with hearing or balance disorders.

Intracellular membranes refer to the membrane structures that exist within a eukaryotic cell (excluding bacteria and archaea, which are prokaryotic and do not have intracellular membranes). These membranes compartmentalize the cell, creating distinct organelles or functional regions with specific roles in various cellular processes.

Major types of intracellular membranes include:

1. Nuclear membrane (nuclear envelope): A double-membraned structure that surrounds and protects the genetic material within the nucleus. It consists of an outer and inner membrane, perforated by nuclear pores that regulate the transport of molecules between the nucleus and cytoplasm.
2. Endoplasmic reticulum (ER): An extensive network of interconnected tubules and sacs that serve as a major site for protein folding, modification, and lipid synthesis. The ER has two types: rough ER (with ribosomes on its surface) and smooth ER (without ribosomes).
3. Golgi apparatus/Golgi complex: A series of stacked membrane-bound compartments that process, sort, and modify proteins and lipids before they are transported to their final destinations within the cell or secreted out of the cell.
4. Lysosomes: Membrane-bound organelles containing hydrolytic enzymes for breaking down various biomolecules (proteins, carbohydrates, lipids, and nucleic acids) in the process called autophagy or from outside the cell via endocytosis.
5. Peroxisomes: Single-membrane organelles involved in various metabolic processes, such as fatty acid oxidation and detoxification of harmful substances like hydrogen peroxide.
6. Vacuoles: Membrane-bound compartments that store and transport various molecules, including nutrients, waste products, and enzymes. Plant cells have a large central vacuole for maintaining turgor pressure and storing metabolites.
7. Mitochondria: Double-membraned organelles responsible for generating energy (ATP) through oxidative phosphorylation and other metabolic processes, such as the citric acid cycle and fatty acid synthesis.
8. Chloroplasts: Double-membraned organelles found in plant cells that convert light energy into chemical energy during photosynthesis, producing oxygen and organic compounds (glucose) from carbon dioxide and water.
9. Endoplasmic reticulum (ER): A network of interconnected membrane-bound tubules involved in protein folding, modification, and transport; it is divided into two types: rough ER (with ribosomes on the surface) and smooth ER (without ribosomes).
10. Nucleus: Double-membraned organelle containing genetic material (DNA) and associated proteins involved in replication, transcription, RNA processing, and DNA repair. The nuclear membrane separates the nucleoplasm from the cytoplasm and contains nuclear pores for transporting molecules between the two compartments.

The auditory threshold is the minimum sound intensity or loudness level that a person can detect 50% of the time, for a given tone frequency. It is typically measured in decibels (dB) and represents the quietest sound that a person can hear. The auditory threshold can be affected by various factors such as age, exposure to noise, and certain medical conditions. Hearing tests, such as pure-tone audiometry, are used to measure an individual's auditory thresholds for different frequencies.

Perilymph is a type of fluid found in the inner ear, more specifically within the bony labyrinth of the inner ear. It fills the space between the membranous labyrinth and the bony labyrinth in the cochlea and vestibular system. Perilymph is similar in composition to cerebrospinal fluid (CSF) and contains sodium, chloride, and protein ions. Its main function is to protect the inner ear from damage, maintain hydrostatic pressure, and facilitate the transmission of sound waves to the hair cells in the cochlea for hearing.

The retina is the innermost, light-sensitive layer of tissue in the eye of many vertebrates and some cephalopods. It receives light that has been focused by the cornea and lens, converts it into neural signals, and sends these to the brain via the optic nerve. The retina contains several types of photoreceptor cells including rods (which handle vision in low light) and cones (which are active in bright light and are capable of color vision).

In medical terms, any pathological changes or diseases affecting the retinal structure and function can lead to visual impairment or blindness. Examples include age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinitis pigmentosa among others.

Bone conduction is a type of hearing mechanism that involves the transmission of sound vibrations directly to the inner ear through the bones of the skull, bypassing the outer and middle ears. This occurs when sound waves cause the bones in the skull to vibrate, stimulating the cochlea (the spiral cavity of the inner ear) and its hair cells, which convert the mechanical energy of the vibrations into electrical signals that are sent to the brain and interpreted as sound.

Bone conduction is a natural part of the hearing process in humans, but it can also be used artificially through the use of bone-conduction devices, such as hearing aids or headphones, which transmit sound vibrations directly to the skull. This type of transmission can provide improved hearing for individuals with conductive hearing loss, mixed hearing loss, or single-sided deafness, as it bypasses damaged or obstructed outer and middle ears.

The Eustachian tube, also known as the auditory tube or pharyngotympanic tube, is a narrow canal that connects the middle ear cavity to the back of the nasopharynx (the upper part of the throat behind the nose). Its function is to maintain equal air pressure on both sides of the eardrum and to drain any fluid accumulation from the middle ear. The Eustachian tube is lined with mucous membrane and contains tiny hair-like structures called cilia that help to move mucus and fluid out of the middle ear. It opens and closes to regulate air pressure and drainage, which typically occurs during swallowing or yawning.

Labyrinth supporting cells are specialized cells that are located in the inner ear and provide structural and functional support to the sensory hair cells within the labyrinth, which is the complex system of tubes and sacs responsible for maintaining balance and hearing. These supporting cells form a crucial part of the architecture of the inner ear and help to maintain the proper functioning of the sensory hair cells by providing mechanical support, contributing to the development and maintenance of the extracellular matrix, and playing a role in the recycling of neurotransmitters. Additionally, labyrinth supporting cells can also transform into new hair cells in certain circumstances, which has implications for potential regenerative therapies aimed at treating hearing loss and balance disorders.

Membrane proteins are a type of protein that are embedded in the lipid bilayer of biological membranes, such as the plasma membrane of cells or the inner membrane of mitochondria. These proteins play crucial roles in various cellular processes, including:

1. Cell-cell recognition and signaling
2. Transport of molecules across the membrane (selective permeability)
3. Enzymatic reactions at the membrane surface
4. Energy transduction and conversion
5. Mechanosensation and signal transduction

Membrane proteins can be classified into two main categories: integral membrane proteins, which are permanently associated with the lipid bilayer, and peripheral membrane proteins, which are temporarily or loosely attached to the membrane surface. Integral membrane proteins can further be divided into three subcategories based on their topology:

1. Transmembrane proteins, which span the entire width of the lipid bilayer with one or more alpha-helices or beta-barrels.
2. Lipid-anchored proteins, which are covalently attached to lipids in the membrane via a glycosylphosphatidylinositol (GPI) anchor or other lipid modifications.
3. Monotopic proteins, which are partially embedded in the membrane and have one or more domains exposed to either side of the bilayer.

Membrane proteins are essential for maintaining cellular homeostasis and are targets for various therapeutic interventions, including drug development and gene therapy. However, their structural complexity and hydrophobicity make them challenging to study using traditional biochemical methods, requiring specialized techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and single-particle cryo-electron microscopy (cryo-EM).

Vestibular hair cells are specialized sensory receptor cells located in the vestibular system of the inner ear. They play a crucial role in detecting and mediating our sense of balance and spatial orientation by converting mechanical stimuli, such as head movements and gravity, into electrical signals that are sent to the brain.

The hair cells are shaped like a tuft of hair, with stereocilia projecting from their tops. These stereocilia are arranged in rows of graded height, and they are embedded in a gel-like structure within the vestibular organ. When the head moves or changes position, the movement causes deflection of the stereocilia, which opens ion channels at their tips and triggers nerve impulses that are sent to the brain via the vestibular nerve.

There are two types of vestibular hair cells: type I and type II. Type I hair cells have a large, spherical shape and are more sensitive to changes in head position, while type II hair cells are more cylindrical in shape and respond to both linear and angular acceleration. Together, these hair cells help us maintain our balance, coordinate our movements, and keep our eyes focused during head movements.

Cerumen is the medical term for earwax. It is a natural substance produced by the body to protect and clean the ears. Cerumen helps to keep the ear canal moist, which prevents dry, itchy ears, and also traps dirt, dust, and other particles that could harm the eardrum. The earwax then gradually moves out of the ear canal and falls out or is removed during activities like showering or washing the face. While some people may need to have their earwax removed if it builds up and causes hearing problems or discomfort, in most cases, cerumen does not need to be cleaned or removed.

Stria vascularis is a highly vascularized (rich in blood vessels) structure located in the cochlea of the inner ear. It plays a crucial role in the process of hearing by maintaining the endocochlear potential, which is essential for the conversion of sound waves into electrical signals that can be interpreted by the brain. The stria vascularis is composed of three layers: the marginal cells, intermediate cells, and basal cells, which work together to maintain the ionic balance and generate the endocochlear potential. Damage to the stria vascularis can result in hearing loss.

Cochlear diseases refer to conditions that affect the structure or function of the cochlea, which is a part of the inner ear responsible for hearing. These diseases can cause various types and degrees of hearing loss, ranging from mild to profound. Some common cochlear diseases include:

1. Cochlear otosclerosis: A condition where there is abnormal bone growth in the cochlea, which can lead to conductive or sensorineural hearing loss.
2. Cochlear Meniere's disease: A disorder that affects the inner ear and causes vertigo, tinnitus, and fluctuating hearing loss.
3. Cochlear damage due to exposure to loud noises: Prolonged or sudden exposure to loud noises can cause permanent cochlear damage and hearing loss.
4. Presbycusis: Age-related hearing loss that affects the cochlea and other structures of the auditory system.
5. Cochlear nerve tumors: Rare benign or malignant growths on the cochlear nerve can cause hearing loss, tinnitus, and balance problems.
6. Infections: Bacterial or viral infections such as meningitis, labyrinthitis, or otitis media can damage the cochlea and lead to hearing loss.
7. Ototoxicity: Certain medications can be toxic to the cochlea and cause hearing loss, tinnitus, or balance problems.
8. Genetic factors: Inherited genetic mutations can cause various types of cochlear diseases, such as connexin 26 deficiency, Waardenburg syndrome, or Usher syndrome.

It is important to note that early diagnosis and treatment of cochlear diseases can help prevent or minimize hearing loss and other complications.

Otitis externa, also known as swimmer's ear, is a medical condition characterized by inflammation or infection of the external auditory canal (the outermost part of the ear canal leading to the eardrum). It often occurs when water stays in the ear after swimming, creating a moist environment that promotes bacterial growth.

The symptoms of otitis externa may include:
- Redness and swelling of the ear canal
- Pain or discomfort in the ear, especially when moving the jaw or chewing
- Itching in the ear
- Discharge from the ear (pus or clear fluid)
- Hearing loss or difficulty hearing

Otitis externa is typically treated with antibiotic eardrops and sometimes oral antibiotics. Keeping the ear dry during treatment is important to prevent further irritation and promote healing. In severe cases, a healthcare provider may need to clean the ear canal before administering medication.

Collecting kidney tubules, also known as collecting ducts, are the final portion of the renal tubule in the nephron of the kidney. They collect filtrate from the distal convoluted tubules and glomeruli and are responsible for the reabsorption of water and electrolytes back into the bloodstream under the influence of antidiuretic hormone (ADH) and aldosterone. The collecting ducts then deliver the remaining filtrate to the ureter, which transports it to the bladder for storage until urination.

A Blastocyst Inner Cell Mass (ICM) is a group of cells within a blastocyst, which is an early-stage preimplantation embryo that develops in mammals. The blastocyst consists of two main components: the trophectoderm, which forms the outer layer and eventually gives rise to the placenta, and the inner cell mass (ICM), which is a cluster of cells located inside the blastocyst.

The ICM is composed of pluripotent cells that have the ability to differentiate into any of the three primary germ layers: ectoderm, mesoderm, or endoderm. These cells will eventually give rise to the fetus and some extraembryonic structures such as the yolk sac and allantois.

The ICM is an essential part of the blastocyst, and its development and quality are critical factors in the success of assisted reproductive technologies (ART) like in vitro fertilization (IVF). The assessment of the ICM's morphology and cell count can help embryologists evaluate the potential of an embryo to develop into a viable pregnancy.

Menière disease is an inner ear disorder that is characterized by episodes of vertigo (a spinning sensation), tinnitus (ringing or buzzing in the ear), hearing loss, and aural fullness (a feeling of pressure or blockage in the ear). It is caused by an abnormal accumulation of endolymphatic fluid in the inner ear, which can lead to damage of the vestibular system and cochlea. The exact cause of this fluid buildup is not known, but it may be related to genetics, allergies, or autoimmune disorders. Menière disease is typically a chronic condition, with symptoms that can vary in frequency and severity over time. Treatment options include dietary modifications, diuretics, vestibular rehabilitation therapy, and, in some cases, surgery.

Otoscopy is a medical examination procedure used to evaluate the external auditory canal and tympanic membrane (eardrum). It involves the use of an otoscope, a tool that consists of a lighted speculum attached to a handle. The speculum is inserted into the ear canal, allowing the healthcare provider to visualize and inspect the eardrum for any abnormalities such as perforations, inflammation, fluid accumulation, or foreign bodies. Otoscopy can help diagnose various conditions including ear infections, middle ear disorders, and hearing loss.

Mitochondria are specialized structures located inside cells that convert the energy from food into ATP (adenosine triphosphate), which is the primary form of energy used by cells. They are often referred to as the "powerhouses" of the cell because they generate most of the cell's supply of chemical energy. Mitochondria are also involved in various other cellular processes, such as signaling, differentiation, and apoptosis (programmed cell death).

Mitochondria have their own DNA, known as mitochondrial DNA (mtDNA), which is inherited maternally. This means that mtDNA is passed down from the mother to her offspring through the egg cells. Mitochondrial dysfunction has been linked to a variety of diseases and conditions, including neurodegenerative disorders, diabetes, and aging.

Pure-tone audiometry is a hearing test that measures a person's ability to hear different sounds, pitches, or frequencies. During the test, pure tones are presented to the patient through headphones or ear inserts, and the patient is asked to indicate each time they hear the sound by raising their hand, pressing a button, or responding verbally.

The softest sound that the person can hear at each frequency is recorded as the hearing threshold, and a graph called an audiogram is created to show the results. The audiogram provides information about the type and degree of hearing loss in each ear. Pure-tone audiometry is a standard hearing test used to diagnose and monitor hearing disorders.

Audiometry is the testing of a person's ability to hear different sounds, pitches, or frequencies. It is typically conducted using an audiometer, a device that emits tones at varying volumes and frequencies. The person being tested wears headphones and indicates when they can hear the tone by pressing a button or raising their hand.

There are two main types of audiometry: pure-tone audiometry and speech audiometry. Pure-tone audiometry measures a person's ability to hear different frequencies at varying volumes, while speech audiometry measures a person's ability to understand spoken words at different volumes and in the presence of background noise.

The results of an audiometry test are typically plotted on an audiogram, which shows the quietest sounds that a person can hear at different frequencies. This information can be used to diagnose hearing loss, determine its cause, and develop a treatment plan.

Hearing disorders, also known as hearing impairments or auditory impairments, refer to conditions that affect an individual's ability to hear sounds in one or both ears. These disorders can range from mild to profound and may result from genetic factors, aging, exposure to loud noises, infections, trauma, or certain medical conditions.

There are mainly two types of hearing disorders: conductive hearing loss and sensorineural hearing loss. Conductive hearing loss occurs when there is a problem with the outer or middle ear, preventing sound waves from reaching the inner ear. Causes include earwax buildup, fluid in the middle ear, a perforated eardrum, or damage to the ossicles (the bones in the middle ear).

Sensorineural hearing loss, on the other hand, is caused by damage to the inner ear (cochlea) or the nerve pathways from the inner ear to the brain. This type of hearing loss is often permanent and can be due to aging (presbycusis), exposure to loud noises, genetics, viral infections, certain medications, or head injuries.

Mixed hearing loss is a combination of both conductive and sensorineural components. In some cases, hearing disorders can also involve tinnitus (ringing or other sounds in the ears) or vestibular problems that affect balance and equilibrium.

Early identification and intervention for hearing disorders are crucial to prevent further deterioration and to help individuals develop appropriate communication skills and maintain a good quality of life.

Mitochondrial membranes refer to the double-layered structure that surrounds the mitochondrion, an organelle found in the cells of most eukaryotes. The outer mitochondrial membrane is a smooth, porous membrane that allows small molecules and ions to pass through freely, while the inner mitochondrial membrane is highly folded and selectively permeable, controlling the movement of larger molecules and maintaining the electrochemical gradient necessary for ATP synthesis. The space between the two membranes is called the intermembrane space, and the space within the inner membrane is called the matrix. Together, these membranes play a crucial role in energy production, metabolism, and cellular homeostasis.

Developmental gene expression regulation refers to the processes that control the activation or repression of specific genes during embryonic and fetal development. These regulatory mechanisms ensure that genes are expressed at the right time, in the right cells, and at appropriate levels to guide proper growth, differentiation, and morphogenesis of an organism.

Developmental gene expression regulation is a complex and dynamic process involving various molecular players, such as transcription factors, chromatin modifiers, non-coding RNAs, and signaling molecules. These regulators can interact with cis-regulatory elements, like enhancers and promoters, to fine-tune the spatiotemporal patterns of gene expression during development.

Dysregulation of developmental gene expression can lead to various congenital disorders and developmental abnormalities. Therefore, understanding the principles and mechanisms governing developmental gene expression regulation is crucial for uncovering the etiology of developmental diseases and devising potential therapeutic strategies.

The cochlear duct, also known as the scala media, is a membranous duct located within the cochlea of the inner ear. It is one of three fluid-filled compartments in the cochlea, along with the vestibular duct (scala vestibuli) and the tympanic duct (scala tympani).

The cochlear duct contains endolymph, a specialized fluid that carries electrical signals to the auditory nerve. The organ of Corti, which is responsible for converting sound vibrations into electrical signals, is located within the cochlear duct.

The cochlear duct runs along the length of the cochlea and is separated from the vestibular duct by Reissner's membrane and from the tympanic duct by the basilar membrane. These membranes help to create a highly sensitive and selective environment for sound perception, allowing us to hear and distinguish different frequencies and intensities of sound.

Acoustic stimulation refers to the use of sound waves or vibrations to elicit a response in an individual, typically for the purpose of assessing or treating hearing, balance, or neurological disorders. In a medical context, acoustic stimulation may involve presenting pure tones, speech sounds, or other types of auditory signals through headphones, speakers, or specialized devices such as bone conduction transducers.

The response to acoustic stimulation can be measured using various techniques, including electrophysiological tests like auditory brainstem responses (ABRs) or otoacoustic emissions (OAEs), behavioral observations, or functional imaging methods like fMRI. Acoustic stimulation is also used in therapeutic settings, such as auditory training programs for hearing impairment or vestibular rehabilitation for balance disorders.

It's important to note that acoustic stimulation should be administered under the guidance of a qualified healthcare professional to ensure safety and effectiveness.

The endolymphatic sac is a small, fluid-filled structure that is part of the inner ear. It is located near the vestibular aqueduct and is responsible for maintaining the balance of fluids in the inner ear. The endolymphatic sac also plays a role in the resorption of endolymph, which is the fluid that fills the membranous labyrinth of the inner ear. Disorders of the endolymphatic sac can lead to conditions such as Meniere's disease, which is characterized by vertigo, hearing loss, and tinnitus.

Otologic surgical procedures refer to a range of surgeries performed on the ear or its related structures. These procedures are typically conducted by otologists, who are specialists trained in diagnosing and treating conditions that affect the ears, balance system, and related nerves. The goal of otologic surgery can vary from repairing damaged bones in the middle ear to managing hearing loss, tumors, or chronic infections. Some common otologic surgical procedures include:

1. Stapedectomy/Stapedotomy: These are procedures used to treat otosclerosis, a condition where the stapes bone in the middle ear becomes fixed and causes conductive hearing loss. The surgeon creates an opening in the stapes footplate (stapedotomy) or removes the entire stapes bone (stapedectomy) and replaces it with a prosthetic device to improve sound conduction.
2. Myringoplasty/Tympanoplasty: These are surgeries aimed at repairing damaged eardrums (tympanic membrane). A myringoplasty involves grafting a piece of tissue over the perforation in the eardrum, while a tympanoplasty includes both eardrum repair and reconstruction of the middle ear bones if necessary.
3. Mastoidectomy: This procedure involves removing the mastoid air cells, which are located in the bony prominence behind the ear. A mastoidectomy is often performed to treat chronic mastoiditis, cholesteatoma, or complications from middle ear infections.
4. Ossiculoplasty: This procedure aims to reconstruct and improve the function of the ossicles (middle ear bones) when they are damaged due to various reasons such as infection, trauma, or congenital conditions. The surgeon uses prosthetic devices made from plastic, metal, or even bone to replace or support the damaged ossicles.
5. Cochlear implantation: This is a surgical procedure that involves placing an electronic device inside the inner ear to help individuals with severe to profound hearing loss. The implant consists of an external processor and internal components that directly stimulate the auditory nerve, bypassing the damaged hair cells in the cochlea.
6. Labyrinthectomy: This procedure involves removing the balance-sensing structures (vestibular system) inside the inner ear to treat severe vertigo or dizziness caused by conditions like Meniere's disease when other treatments have failed.
7. Acoustic neuroma removal: An acoustic neuroma is a benign tumor that grows on the vestibulocochlear nerve, which connects the inner ear to the brain. Surgical removal of the tumor is necessary to prevent hearing loss, balance problems, and potential neurological complications.

These are just a few examples of the various surgical procedures performed by otolaryngologists (ear, nose, and throat specialists) to treat conditions affecting the ear and surrounding structures. Each procedure has its specific indications, benefits, risks, and postoperative care requirements. Patients should consult with their healthcare providers to discuss the most appropriate treatment options for their individual needs.

Membrane transport proteins are specialized biological molecules, specifically integral membrane proteins, that facilitate the movement of various substances across the lipid bilayer of cell membranes. They are responsible for the selective and regulated transport of ions, sugars, amino acids, nucleotides, and other molecules into and out of cells, as well as within different cellular compartments. These proteins can be categorized into two main types: channels and carriers (or pumps). Channels provide a passive transport mechanism, allowing ions or small molecules to move down their electrochemical gradient, while carriers actively transport substances against their concentration gradient, requiring energy usually in the form of ATP. Membrane transport proteins play a crucial role in maintaining cell homeostasis, signaling processes, and many other physiological functions.

Noise-induced hearing loss (NIHL) is a type of sensorineural hearing loss that occurs due to exposure to harmful levels of noise. The damage can be caused by a one-time exposure to an extremely loud sound or by continuous exposure to lower level sounds over time. NIHL can affect people of all ages and can cause permanent damage to the hair cells in the cochlea, leading to hearing loss, tinnitus (ringing in the ears), and difficulty understanding speech in noisy environments. Prevention measures include avoiding excessive noise exposure, wearing hearing protection, and taking regular breaks from noisy activities.

Auditory outer hair cells are specialized sensory receptor cells located in the cochlea of the inner ear. They are part of the organ of Corti and play a crucial role in hearing by converting sound energy into electrical signals that can be interpreted by the brain.

Unlike the more numerous and simpler auditory inner hair cells, outer hair cells are equipped with unique actin-based molecular motors called "motile" or "piezoelectric" properties. These motors enable the outer hair cells to change their shape and length in response to electrical signals, which in turn amplifies the mechanical vibrations of the basilar membrane where they are located. This amplification increases the sensitivity and frequency selectivity of hearing, allowing us to detect and discriminate sounds over a wide range of intensities and frequencies.

Damage or loss of outer hair cells is a common cause of sensorineural hearing loss, which can result from exposure to loud noises, aging, genetics, ototoxic drugs, and other factors. Currently, there are no effective treatments to regenerate or replace damaged outer hair cells, making hearing loss an irreversible condition in most cases.

Acupuncture, Ear is a form of acupuncture that involves stimulating specific points on the ear to treat various health conditions. This technique is based on the idea that the ear is a microsystem that reflects the entire body, with each point on the ear corresponding to a specific organ or part of the body.

In ear acupuncture, fine needles are inserted into the selected points on the ear and left in place for a period of time, ranging from a few minutes to several days. Sometimes, electrical stimulation or heat may be applied to the needles to enhance the treatment's effectiveness.

Ear acupuncture is used to treat a wide range of conditions, including chronic pain, addiction, stress, anxiety, insomnia, digestive problems, and weight loss. It is also used as a complementary therapy in conjunction with other forms of medical or psychological treatment.

The mastoid is a term used in anatomy and refers to the bony prominence located at the base of the skull, posterior to the ear. More specifically, it's part of the temporal bone, one of the bones that forms the side and base of the skull. The mastoid process provides attachment for various muscles involved in chewing and moving the head.

In a medical context, "mastoid" can also refer to conditions or procedures related to this area. For example, mastoiditis is an infection of the mastoid process, while a mastoidectomy is a surgical procedure that involves removing part or all of the mastoid process.

The inner segment of a retinal photoreceptor cell, also known as the inner segment of a rod or cone cell, is the portion of the cell that contains the majority of its metabolic and energy-generating components. It is responsible for providing the energy needed for the outer segment, which is the part of the cell that contains the visual pigments and is responsible for phototransduction, or the conversion of light into electrical signals.

The inner segment is divided into two main parts: the ellipsoid and the myoid. The ellipsoid contains a high concentration of mitochondria, which provide energy to the cell through the process of oxidative phosphorylation. The myoid contains the endoplasmic reticulum and the Golgi apparatus, which are involved in protein synthesis and transport.

Damage to the inner segment of the retinal photoreceptor cells can lead to vision loss or impairment, as it can affect the ability of the outer segment to function properly and transmit visual signals to the brain.

Electron microscopy (EM) is a type of microscopy that uses a beam of electrons to create an image of the sample being examined, resulting in much higher magnification and resolution than light microscopy. There are several types of electron microscopy, including transmission electron microscopy (TEM), scanning electron microscopy (SEM), and reflection electron microscopy (REM).

In TEM, a beam of electrons is transmitted through a thin slice of the sample, and the electrons that pass through the sample are focused to form an image. This technique can provide detailed information about the internal structure of cells, viruses, and other biological specimens, as well as the composition and structure of materials at the atomic level.

In SEM, a beam of electrons is scanned across the surface of the sample, and the electrons that are scattered back from the surface are detected to create an image. This technique can provide information about the topography and composition of surfaces, as well as the structure of materials at the microscopic level.

REM is a variation of SEM in which the beam of electrons is reflected off the surface of the sample, rather than scattered back from it. This technique can provide information about the surface chemistry and composition of materials.

Electron microscopy has a wide range of applications in biology, medicine, and materials science, including the study of cellular structure and function, disease diagnosis, and the development of new materials and technologies.

An amino acid sequence is the specific order of amino acids in a protein or peptide molecule, formed by the linking of the amino group (-NH2) of one amino acid to the carboxyl group (-COOH) of another amino acid through a peptide bond. The sequence is determined by the genetic code and is unique to each type of protein or peptide. It plays a crucial role in determining the three-dimensional structure and function of proteins.

Molecular sequence data refers to the specific arrangement of molecules, most commonly nucleotides in DNA or RNA, or amino acids in proteins, that make up a biological macromolecule. This data is generated through laboratory techniques such as sequencing, and provides information about the exact order of the constituent molecules. This data is crucial in various fields of biology, including genetics, evolution, and molecular biology, allowing for comparisons between different organisms, identification of genetic variations, and studies of gene function and regulation.

In the context of medicine, particularly in the field of auscultation (the act of listening to the internal sounds of the body), "sound" refers to the noises produced by the functioning of the heart, lungs, and other organs. These sounds are typically categorized into two types:

1. **Bradyacoustic sounds**: These are low-pitched sounds that are heard when there is a turbulent flow of blood or when two body structures rub against each other. An example would be the heart sound known as "S1," which is produced by the closure of the mitral and tricuspid valves at the beginning of systole (contraction of the heart's ventricles).

2. **High-pitched sounds**: These are sharper, higher-frequency sounds that can provide valuable diagnostic information. An example would be lung sounds, which include breath sounds like those heard during inhalation and exhalation, as well as adventitious sounds like crackles, wheezes, and pleural friction rubs.

It's important to note that these medical "sounds" are not the same as the everyday definition of sound, which refers to the sensation produced by stimulation of the auditory system by vibrations.

Cochlear microphonic potentials (CMs) are electrical responses that originate from the hair cells in the cochlea, which is a part of the inner ear responsible for hearing. These potentials can be recorded using an electrode placed near the cochlea in response to sound stimulation.

The CMs are considered to be a passive response of the hair cells to the mechanical deflection caused by sound waves. They represent the receptor potential of the outer hair cells and are directly proportional to the sound pressure level. Unlike other electrical responses in the cochlea, such as the action potentials generated by the auditory nerve fibers, CMs do not require the presence of neurotransmitters or synaptic transmission.

Cochlear microphonic potentials have been used in research to study the biophysical properties of hair cells and their response to different types of sound stimuli. However, they are not typically used in clinical audiology due to their small amplitude and susceptibility to interference from other electrical signals in the body.

The cochlear nerve, also known as the auditory nerve, is the sensory nerve that transmits sound signals from the inner ear to the brain. It consists of two parts: the outer spiral ganglion and the inner vestibular portion. The spiral ganglion contains the cell bodies of the bipolar neurons that receive input from hair cells in the cochlea, which is the snail-shaped organ in the inner ear responsible for hearing. These neurons then send their axons to form the cochlear nerve, which travels through the internal auditory meatus and synapses with neurons in the cochlear nuclei located in the brainstem.

Damage to the cochlear nerve can result in hearing loss or deafness, depending on the severity of the injury. Common causes of cochlear nerve damage include acoustic trauma, such as exposure to loud noises, viral infections, meningitis, and tumors affecting the nerve or surrounding structures. In some cases, cochlear nerve damage may be treated with hearing aids, cochlear implants, or other assistive devices to help restore or improve hearing function.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

Biological models, also known as physiological models or organismal models, are simplified representations of biological systems, processes, or mechanisms that are used to understand and explain the underlying principles and relationships. These models can be theoretical (conceptual or mathematical) or physical (such as anatomical models, cell cultures, or animal models). They are widely used in biomedical research to study various phenomena, including disease pathophysiology, drug action, and therapeutic interventions.

Examples of biological models include:

1. Mathematical models: These use mathematical equations and formulas to describe complex biological systems or processes, such as population dynamics, metabolic pathways, or gene regulation networks. They can help predict the behavior of these systems under different conditions and test hypotheses about their underlying mechanisms.
2. Cell cultures: These are collections of cells grown in a controlled environment, typically in a laboratory dish or flask. They can be used to study cellular processes, such as signal transduction, gene expression, or metabolism, and to test the effects of drugs or other treatments on these processes.
3. Animal models: These are living organisms, usually vertebrates like mice, rats, or non-human primates, that are used to study various aspects of human biology and disease. They can provide valuable insights into the pathophysiology of diseases, the mechanisms of drug action, and the safety and efficacy of new therapies.
4. Anatomical models: These are physical representations of biological structures or systems, such as plastic models of organs or tissues, that can be used for educational purposes or to plan surgical procedures. They can also serve as a basis for developing more sophisticated models, such as computer simulations or 3D-printed replicas.

Overall, biological models play a crucial role in advancing our understanding of biology and medicine, helping to identify new targets for therapeutic intervention, develop novel drugs and treatments, and improve human health.

A cell membrane, also known as the plasma membrane, is a thin semi-permeable phospholipid bilayer that surrounds all cells in animals, plants, and microorganisms. It functions as a barrier to control the movement of substances in and out of the cell, allowing necessary molecules such as nutrients, oxygen, and signaling molecules to enter while keeping out harmful substances and waste products. The cell membrane is composed mainly of phospholipids, which have hydrophilic (water-loving) heads and hydrophobic (water-fearing) tails. This unique structure allows the membrane to be flexible and fluid, yet selectively permeable. Additionally, various proteins are embedded in the membrane that serve as channels, pumps, receptors, and enzymes, contributing to the cell's overall functionality and communication with its environment.

Vestibular diseases are a group of disorders that affect the vestibular system, which is responsible for maintaining balance and spatial orientation. The vestibular system includes the inner ear and parts of the brain that process sensory information related to movement and position.

These diseases can cause symptoms such as vertigo (a spinning sensation), dizziness, imbalance, nausea, and visual disturbances. Examples of vestibular diseases include:

1. Benign paroxysmal positional vertigo (BPPV): a condition in which small crystals in the inner ear become dislodged and cause brief episodes of vertigo triggered by changes in head position.
2. Labyrinthitis: an inner ear infection that can cause sudden onset of vertigo, hearing loss, and tinnitus (ringing in the ears).
3. Vestibular neuronitis: inflammation of the vestibular nerve that causes severe vertigo, nausea, and imbalance but typically spares hearing.
4. Meniere's disease: a disorder characterized by recurrent episodes of vertigo, tinnitus, hearing loss, and a feeling of fullness in the affected ear.
5. Vestibular migraine: a type of migraine that includes vestibular symptoms such as dizziness, imbalance, and disorientation.
6. Superior canal dehiscence syndrome: a condition in which there is a thinning or absence of bone over the superior semicircular canal in the inner ear, leading to vertigo, sound- or pressure-induced dizziness, and hearing loss.
7. Bilateral vestibular hypofunction: reduced function of both vestibular systems, causing chronic imbalance, unsteadiness, and visual disturbances.

Treatment for vestibular diseases varies depending on the specific diagnosis but may include medication, physical therapy, surgery, or a combination of these approaches.

The spiral ganglion is a structure located in the inner ear, specifically within the cochlea. It consists of nerve cell bodies that form the sensory component of the auditory nervous system. The spiral ganglion's neurons are bipolar and have peripheral processes that form synapses with hair cells in the organ of Corti, which is responsible for converting sound vibrations into electrical signals.

The central processes of these neurons then coalesce to form the cochlear nerve, which transmits these electrical signals to the brainstem and ultimately to the auditory cortex for processing and interpretation as sound. Damage to the spiral ganglion or its associated neural structures can lead to hearing loss or deafness.

The oval window ( fenestra vestibuli ) is a small opening in the inner ear, specifically in the bony labyrinth of the temporal bone. It connects the middle ear to the vestibular system of the inner ear, more precisely to the vestibule. The oval window is covered by the base of the stapes, one of the three smallest bones in the human body, also known as the stirrup. This arrangement allows for the transmission of vibratory energy from the tympanic membrane (eardrum) to the inner ear, which is essential for hearing.

"Otitis" is a general medical term that refers to inflammation or infection in the ear. It can be further classified into different types depending on the part of the ear affected:

1. Otitis externa, also known as swimmer's ear, affects the outer ear and ear canal.
2. Otitis media is an infection or inflammation of the middle ear.
3. Otitis interna, or labyrinthitis, refers to inflammation of the inner ear.

The symptoms of otitis can vary but often include pain, hearing loss, and discharge. The specific treatment will depend on the type and severity of the otitis.

The Scala Tympani is a part of the inner ear's bony labyrinth, specifically within the cochlea. It is one of the two channels (the other being the Scala Vestibuli) that make up the bony duct of the cochlea, through which sound waves are transmitted to the inner ear.

The Scala Tympani starts at the round window, which is a membrane-covered opening located on the cochlea's outer wall. It runs parallel to the Scala Vestibuli and connects with it at the helicotrema, a small opening at the apex or tip of the cochlea.

When sound waves reach the inner ear, they cause vibrations in the fluid-filled Scala Tympani and Scala Vestibuli, which stimulate hair cells within the organ of Corti, leading to the conversion of mechanical energy into electrical signals that are then transmitted to the brain via the auditory nerve.

It's important to note that any damage or dysfunction in the Scala Tympani or other parts of the inner ear can lead to hearing loss or other auditory disorders.

Stereocilia are hair-like projections found in the inner ear, more specifically in the organ of Corti within the cochlea. They are present on the sensory cells known as hair cells and are involved in hearing by converting sound vibrations into electrical signals that can be transmitted to the brain.

Stereocilia are arranged in rows of graded height, with the tallest ones located near the opening of the cochlea (the base) and the shortest ones closer to the apex. When sound waves reach the inner ear, they cause the fluid within the cochlea to move, which in turn causes stereocilia to bend. This bending action triggers the release of chemical signals that stimulate nerve fibers connected to the hair cells, ultimately transmitting information about the sound to the brain.

Damage or loss of stereocilia can result in hearing impairment or deafness, as seen in various forms of hearing disorders and age-related hearing loss.

Auditory pathways refer to the series of structures and nerves in the body that are involved in processing sound and transmitting it to the brain for interpretation. The process begins when sound waves enter the ear and cause vibrations in the eardrum, which then move the bones in the middle ear. These movements stimulate hair cells in the cochlea, a spiral-shaped structure in the inner ear, causing them to release neurotransmitters that activate auditory nerve fibers.

The auditory nerve carries these signals to the brainstem, where they are relayed through several additional structures before reaching the auditory cortex in the temporal lobe of the brain. Here, the signals are processed and interpreted as sounds, allowing us to hear and understand speech, music, and other environmental noises.

Damage or dysfunction at any point along the auditory pathway can lead to hearing loss or impairment.

In situ hybridization (ISH) is a molecular biology technique used to detect and localize specific nucleic acid sequences, such as DNA or RNA, within cells or tissues. This technique involves the use of a labeled probe that is complementary to the target nucleic acid sequence. The probe can be labeled with various types of markers, including radioisotopes, fluorescent dyes, or enzymes.

During the ISH procedure, the labeled probe is hybridized to the target nucleic acid sequence in situ, meaning that the hybridization occurs within the intact cells or tissues. After washing away unbound probe, the location of the labeled probe can be visualized using various methods depending on the type of label used.

In situ hybridization has a wide range of applications in both research and diagnostic settings, including the detection of gene expression patterns, identification of viral infections, and diagnosis of genetic disorders.

An earache is defined as a pain or discomfort in the ear. It can occur in either the outer, middle, or inner ear. The pain may be sharp, dull, constant, or intermittent and can vary in intensity from mild to severe. Earaches are often accompanied by other symptoms such as hearing loss, ringing in the ears (tinnitus), and feelings of pressure or fullness in the ear. In some cases, an earache may be a symptom of an underlying medical condition, such as an ear infection, swimmer's ear, or a ruptured eardrum. If you are experiencing an earache that is severe or persistent, it is important to seek medical attention from a healthcare professional.

Tympanic membrane perforation, also known as a ruptured eardrum, is a tear or hole in the tympanic membrane, which separates the outer ear canal and the middle ear. The tympanic membrane plays a crucial role in hearing by transmitting sound vibrations from the outer ear to the inner ear. A perforation can result from various causes such as infection, trauma, pressure changes, or explosive blasts, leading to symptoms like hearing loss, tinnitus, vertigo, and ear discharge. The extent and location of the perforation determine the severity of the symptoms and the course of treatment, which may include observation, antibiotics, or surgical repair.

The incus, also known as the anvil, is one of the three smallest bones in the middle ear, located in the ossicular chain. It articulates with the malleus (hammer) and stapes (stirrup). The incus helps transmit and amplify sound vibrations from the eardrum to the inner ear.

Labyrinthitis is a medical condition characterized by inflammation of the labyrinth, which is the inner ear's balance- and hearing-sensitive system. It is often caused by an infection, such as a viral or bacterial infection, that spreads to the inner ear. The inflammation can affect the delicate structures of the labyrinth, leading to symptoms such as vertigo (a spinning sensation), dizziness, imbalance, hearing loss, and tinnitus (ringing in the ears). Labyrinthitis can be a serious condition that requires medical attention and treatment.

Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.

A zebrafish is a freshwater fish species belonging to the family Cyprinidae and the genus Danio. Its name is derived from its distinctive striped pattern that resembles a zebra's. Zebrafish are often used as model organisms in scientific research, particularly in developmental biology, genetics, and toxicology studies. They have a high fecundity rate, transparent embryos, and a rapid development process, making them an ideal choice for researchers. However, it is important to note that providing a medical definition for zebrafish may not be entirely accurate or relevant since they are primarily used in biological research rather than clinical medicine.

Tympanoplasty is a surgical procedure performed to reconstruct or repair the tympanic membrane (eardrum) and/or the small bones of the middle ear (ossicles). The primary goal of this surgery is to restore hearing, but it can also help manage chronic middle ear infections, traumatic eardrum perforations, or cholesteatoma (a skin growth in the middle ear).

During the procedure, a surgeon may use various techniques such as grafting tissue from another part of the body to rebuild the eardrum or using prosthetic materials to reconstruct the ossicles. The choice of technique depends on the extent and location of the damage. Tympanoplasty is typically an outpatient procedure, meaning patients can return home on the same day of the surgery.

The vestibulocochlear nerve, also known as the auditory-vestibular nerve or cranial nerve VIII, is a paired peripheral nerve that transmits sensory information from the inner ear to the brain. It has two distinct parts: the cochlear part and the vestibular part.

The cochlear part is responsible for hearing and transmits sound signals from the cochlea to the brain. The vestibular part, on the other hand, is responsible for maintaining balance and spatial orientation by transmitting information about head movement and position from the vestibular apparatus (utricle, saccule, and semicircular canals) in the inner ear to the brain.

Together, these two parts of the vestibulocochlear nerve play a crucial role in our ability to hear and maintain balance. Damage to this nerve can result in hearing loss, tinnitus (ringing in the ears), vertigo (dizziness), or balance problems.

The PAX2 transcription factor is a protein that plays a crucial role in the development and function of the kidneys and urinary system. It belongs to the PAX family of transcription factors, which are characterized by a highly conserved DNA-binding domain called the paired box. The PAX2 protein helps regulate gene expression during embryonic development, including genes involved in the formation of the nephrons, the functional units of the kidneys.

PAX2 is expressed in the intermediate mesoderm, which gives rise to the kidneys and other organs of the urinary system. It helps to specify the fate of these cells and promote their differentiation into mature kidney structures. In addition to its role in kidney development, PAX2 has also been implicated in the development of the eye, ear, and central nervous system.

Mutations in the PAX2 gene have been associated with various genetic disorders, including renal coloboma syndrome, which is characterized by kidney abnormalities and eye defects. Proper regulation of PAX2 expression is essential for normal development and function of the urinary system and other organs.

A blastocyst is a stage in the early development of a fertilized egg, or embryo, in mammals. It occurs about 5-6 days after fertilization and consists of an outer layer of cells called trophoblasts, which will eventually form the placenta, and an inner cell mass, which will give rise to the fetus. The blastocyst is characterized by a fluid-filled cavity called the blastocoel. This stage is critical for the implantation of the embryo into the uterine lining.

A hearing test is a procedure used to evaluate a person's ability to hear different sounds, pitches, or frequencies. It is performed by a hearing healthcare professional in a sound-treated booth or room with calibrated audiometers. The test measures a person's hearing sensitivity at different frequencies and determines the quietest sounds they can hear, known as their hearing thresholds.

There are several types of hearing tests, including:

1. Pure Tone Audiometry (PTA): This is the most common type of hearing test, where the person is presented with pure tones at different frequencies and volumes through headphones or ear inserts. The person indicates when they hear the sound by pressing a button or raising their hand.
2. Speech Audiometry: This test measures a person's ability to understand speech at different volume levels. The person is asked to repeat words presented to them in quiet and in background noise.
3. Tympanometry: This test measures the function of the middle ear by creating variations in air pressure in the ear canal. It can help identify issues such as fluid buildup or a perforated eardrum.
4. Acoustic Reflex Testing: This test measures the body's natural response to loud sounds and can help identify the location of damage in the hearing system.
5. Otoacoustic Emissions (OAEs): This test measures the sound that is produced by the inner ear when it is stimulated by a sound. It can help identify cochlear damage or abnormalities.

Hearing tests are important for diagnosing and monitoring hearing loss, as well as identifying any underlying medical conditions that may be causing the hearing problems.

Sound localization is the ability of the auditory system to identify the location or origin of a sound source in the environment. It is a crucial aspect of hearing and enables us to navigate and interact with our surroundings effectively. The process involves several cues, including time differences in the arrival of sound to each ear (interaural time difference), differences in sound level at each ear (interaural level difference), and spectral information derived from the filtering effects of the head and external ears on incoming sounds. These cues are analyzed by the brain to determine the direction and distance of the sound source, allowing for accurate localization.

The nuclear envelope is a complex and double-membrane structure that surrounds the eukaryotic cell's nucleus. It consists of two distinct membranes: the outer nuclear membrane, which is continuous with the endoplasmic reticulum (ER) membrane, and the inner nuclear membrane, which is closely associated with the chromatin and nuclear lamina.

The nuclear envelope serves as a selective barrier between the nucleus and the cytoplasm, controlling the exchange of materials and information between these two cellular compartments. Nuclear pore complexes (NPCs) are embedded in the nuclear envelope at sites where the inner and outer membranes fuse, forming aqueous channels that allow for the passive or active transport of molecules, such as ions, metabolites, and RNA-protein complexes.

The nuclear envelope plays essential roles in various cellular processes, including DNA replication, transcription, RNA processing, and chromosome organization. Additionally, it is dynamically regulated during the cell cycle, undergoing disassembly and reformation during mitosis to facilitate equal distribution of genetic material between daughter cells.

Mitochondrial proteins are any proteins that are encoded by the nuclear genome or mitochondrial genome and are located within the mitochondria, an organelle found in eukaryotic cells. These proteins play crucial roles in various cellular processes including energy production, metabolism of lipids, amino acids, and steroids, regulation of calcium homeostasis, and programmed cell death or apoptosis.

Mitochondrial proteins can be classified into two main categories based on their origin:

1. Nuclear-encoded mitochondrial proteins (NEMPs): These are proteins that are encoded by genes located in the nucleus, synthesized in the cytoplasm, and then imported into the mitochondria through specific import pathways. NEMPs make up about 99% of all mitochondrial proteins and are involved in various functions such as oxidative phosphorylation, tricarboxylic acid (TCA) cycle, fatty acid oxidation, and mitochondrial dynamics.

2. Mitochondrial DNA-encoded proteins (MEPs): These are proteins that are encoded by the mitochondrial genome, synthesized within the mitochondria, and play essential roles in the electron transport chain (ETC), a key component of oxidative phosphorylation. The human mitochondrial genome encodes only 13 proteins, all of which are subunits of complexes I, III, IV, and V of the ETC.

Defects in mitochondrial proteins can lead to various mitochondrial disorders, which often manifest as neurological, muscular, or metabolic symptoms due to impaired energy production. These disorders are usually caused by mutations in either nuclear or mitochondrial genes that encode mitochondrial proteins.

Cellular mechanotransduction is the process by which cells convert mechanical stimuli into biochemical signals, resulting in changes in cell behavior and function. This complex process involves various molecular components, including transmembrane receptors, ion channels, cytoskeletal proteins, and signaling molecules. Mechanical forces such as tension, compression, or fluid flow can activate these components, leading to alterations in gene expression, protein synthesis, and cell shape or movement. Cellular mechanotransduction plays a crucial role in various physiological processes, including tissue development, homeostasis, and repair, as well as in pathological conditions such as fibrosis and cancer progression.

Transcription Factor Brn-3C, also known as POU4F3, is a protein involved in the regulation of gene expression. It belongs to the class IV POU domain transcription factor family and plays crucial roles in the development, maintenance, and function of inner ear hair cells, which are essential for hearing. Mutations in the Brn-3C gene have been associated with deafness disorders in humans. The protein works by binding to specific DNA sequences in the promoter regions of target genes and controlling their transcription into messenger RNA (mRNA). This process is critical for various cellular functions, including cell growth, differentiation, and survival.

In the field of medicine, "time factors" refer to the duration of symptoms or time elapsed since the onset of a medical condition, which can have significant implications for diagnosis and treatment. Understanding time factors is crucial in determining the progression of a disease, evaluating the effectiveness of treatments, and making critical decisions regarding patient care.

For example, in stroke management, "time is brain," meaning that rapid intervention within a specific time frame (usually within 4.5 hours) is essential to administering tissue plasminogen activator (tPA), a clot-busting drug that can minimize brain damage and improve patient outcomes. Similarly, in trauma care, the "golden hour" concept emphasizes the importance of providing definitive care within the first 60 minutes after injury to increase survival rates and reduce morbidity.

Time factors also play a role in monitoring the progression of chronic conditions like diabetes or heart disease, where regular follow-ups and assessments help determine appropriate treatment adjustments and prevent complications. In infectious diseases, time factors are crucial for initiating antibiotic therapy and identifying potential outbreaks to control their spread.

Overall, "time factors" encompass the significance of recognizing and acting promptly in various medical scenarios to optimize patient outcomes and provide effective care.

The basilar membrane is a key structure within the inner ear that plays a crucial role in hearing. It is a narrow, flexible strip of tissue located inside the cochlea, which is the spiral-shaped organ responsible for converting sound waves into neural signals that can be interpreted by the brain.

The basilar membrane runs along the length of the cochlea's duct and is attached to the rigid bony structures at both ends. It varies in width and stiffness along its length, with the widest and most flexible portion located near the entrance of the cochlea and the narrowest and stiffest portion located near the apex.

When sound waves enter the inner ear, they cause vibrations in the fluid-filled cochlear duct. These vibrations are transmitted to the basilar membrane, causing it to flex up and down. The specific pattern of flexion along the length of the basilar membrane depends on the frequency of the sound wave. Higher frequency sounds cause maximum flexion near the base of the cochlea, while lower frequency sounds cause maximum flexion near the apex.

As the basilar membrane flexes, it causes the attached hair cells to bend. This bending stimulates the hair cells to release neurotransmitters, which then activate the auditory nerve fibers. The pattern of neural activity in the auditory nerve encodes the frequency and amplitude of the sound wave, allowing the brain to interpret the sound.

Overall, the basilar membrane is a critical component of the hearing process, enabling us to detect and discriminate different sounds based on their frequency and amplitude.

Unilateral hearing loss is a type of hearing impairment that affects only one ear. This condition can be either sensorineural or conductive in nature. Sensorineural hearing loss results from damage to the inner ear or nerve pathways leading to the brain, while conductive hearing loss occurs when sound waves are not properly transmitted through the outer or middle ear. Unilateral hearing loss can result in difficulty hearing and understanding speech, particularly in noisy environments, and can also impact communication and quality of life. The cause of unilateral hearing loss can vary and may include factors such as infection, trauma, genetics, or exposure to loud noise. Treatment options depend on the underlying cause and severity of the hearing loss and may include hearing aids, cochlear implants, or surgical intervention.

Fibroblast Growth Factor 3 (FGF3) is a protein that belongs to the fibroblast growth factor family, which plays crucial roles in various biological processes such as cell survival, proliferation, migration, and differentiation. Specifically, FGF3 is involved in embryonic development, tissue repair, and maintenance of homeostasis. It exerts its functions by binding to FGF receptors (FGFRs) and activating downstream signaling pathways. Mutations in the FGF3 gene have been associated with certain diseases, including craniosynostosis, a condition characterized by premature fusion of skull bones.

Mitochondrial membrane transport proteins are a type of integral membrane proteins located in the inner and outer mitochondrial membranes. They play a crucial role in the regulation of molecule exchange between the cytosol and the mitochondrial matrix, allowing only specific ions and molecules to pass through while maintaining the structural and functional integrity of the mitochondria.

The inner mitochondrial membrane transport proteins, also known as the mitochondrial carrier proteins or the solute carriers, are a family of about 50 different types of proteins that facilitate the passage of various metabolites, such as nucleotides, amino acids, fatty acids, and inorganic ions (like calcium, sodium, and potassium). These transport proteins usually function as exchangers or uniporters, moving one type of solute in one direction in exchange for another type of solute or a proton.

The outer mitochondrial membrane is more permeable than the inner membrane due to the presence of voltage-dependent anion channels (VDACs) and other porins that allow small molecules, ions, and metabolites to pass through. VDACs are the most abundant proteins in the outer mitochondrial membrane and play a significant role in controlling the flow of metabolites between the cytosol and the intermembrane space.

In summary, mitochondrial membrane transport proteins are essential for maintaining the proper functioning of mitochondria by regulating the movement of molecules across the inner and outer membranes. They facilitate the exchange of nutrients, metabolites, and ions required for oxidative phosphorylation, energy production, and other cellular processes.

Animal Identification Systems refer to methods and technologies used for identifying individual animals, typically for the purposes of animal health monitoring, traceability in food production, and conservation efforts. These systems can include various forms of physical tags, electronic identification devices, and data management software. Common examples include ear tags, radio-frequency identification (RFID) transponders, and tattooing or branding. The goal of animal identification systems is to enable accurate tracking and monitoring of animals throughout their lifecycle, which can help prevent the spread of disease, ensure food safety, and support research and conservation efforts.

I'd be happy to help! However, I believe there might be a slight misunderstanding in your question. Mitochondria are organelles found in the cells of all complex living organisms, including humans, while the liver is a large, solid organ located in the upper right portion of the abdomen. They don't have a medical definition together. I can certainly provide you with separate definitions for each:

1. Mitochondria: These are double-membrane-bound cellular organelles that generate most of the chemical energy needed to power the cell's biochemical reactions. Commonly known as the "powerhouse of the cell," mitochondria convert organic substrates, such as glucose, fatty acids, and amino acids, into adenosine triphosphate (ATP) through a process called oxidative phosphorylation. Mitochondria are dynamic structures that can change their shape, size, and number through fission (division) and fusion (merging) processes. They play essential roles in various cellular functions, including calcium signaling, apoptosis (programmed cell death), and the regulation of cellular metabolism.

2. Liver: The liver is a large, lobulated organ that lies mainly in the upper right portion of the abdominal cavity, just below the diaphragm. It plays a crucial role in various physiological functions, such as detoxification, protein synthesis, metabolism, and nutrient storage. The liver is responsible for removing toxins from the bloodstream, producing bile to aid in digestion, regulating glucose levels, synthesizing plasma proteins, and storing glycogen, vitamins, and minerals. It also contributes to the metabolism of carbohydrates, lipids, and amino acids, helping maintain energy homeostasis in the body.

I hope this clarifies any confusion! If you have any further questions or need more information, please don't hesitate to ask.

Audiology is a branch of science that deals with the study of hearing, balance disorders, and related conditions. It involves the assessment, diagnosis, and treatment of hearing and balance problems using various tests, techniques, and devices. Audiologists are healthcare professionals who specialize in this field and provide services such as hearing evaluations, fitting of hearing aids, and counseling for people with hearing loss or tinnitus (ringing in the ears). They also work closely with other medical professionals to manage complex cases and provide rehabilitation services.

Morphogenesis is a term used in developmental biology and refers to the process by which cells give rise to tissues and organs with specific shapes, structures, and patterns during embryonic development. This process involves complex interactions between genes, cells, and the extracellular environment that result in the coordinated movement and differentiation of cells into specialized functional units.

Morphogenesis is a dynamic and highly regulated process that involves several mechanisms, including cell proliferation, death, migration, adhesion, and differentiation. These processes are controlled by genetic programs and signaling pathways that respond to environmental cues and regulate the behavior of individual cells within a developing tissue or organ.

The study of morphogenesis is important for understanding how complex biological structures form during development and how these processes can go awry in disease states such as cancer, birth defects, and degenerative disorders.

Biological transport refers to the movement of molecules, ions, or solutes across biological membranes or through cells in living organisms. This process is essential for maintaining homeostasis, regulating cellular functions, and enabling communication between cells. There are two main types of biological transport: passive transport and active transport.

Passive transport does not require the input of energy and includes:

1. Diffusion: The random movement of molecules from an area of high concentration to an area of low concentration until equilibrium is reached.
2. Osmosis: The diffusion of solvent molecules (usually water) across a semi-permeable membrane from an area of lower solute concentration to an area of higher solute concentration.
3. Facilitated diffusion: The assisted passage of polar or charged substances through protein channels or carriers in the cell membrane, which increases the rate of diffusion without consuming energy.

Active transport requires the input of energy (in the form of ATP) and includes:

1. Primary active transport: The direct use of ATP to move molecules against their concentration gradient, often driven by specific transport proteins called pumps.
2. Secondary active transport: The coupling of the movement of one substance down its electrochemical gradient with the uphill transport of another substance, mediated by a shared transport protein. This process is also known as co-transport or counter-transport.

I believe there may be some confusion in your question. "Rabbits" is a common name used to refer to the Lagomorpha species, particularly members of the family Leporidae. They are small mammals known for their long ears, strong legs, and quick reproduction.

However, if you're referring to "rabbits" in a medical context, there is a term called "rabbit syndrome," which is a rare movement disorder characterized by repetitive, involuntary movements of the fingers, resembling those of a rabbit chewing. It is also known as "finger-chewing chorea." This condition is usually associated with certain medications, particularly antipsychotics, and typically resolves when the medication is stopped or adjusted.

Otolaryngology is a specialized branch of medicine that deals with the diagnosis, management, and treatment of disorders related to the ear, nose, throat (ENT), and head and neck region. It's also known as ENT (Ear, Nose, Throat) specialty. Otolaryngologists are physicians trained in the medical and surgical management of conditions such as hearing and balance disorders, nasal congestion, sinusitis, allergies, sleep apnea, snoring, swallowing difficulties, voice and speech problems, and head and neck tumors.

Photoreceptor cells in vertebrates are specialized types of neurons located in the retina of the eye that are responsible for converting light stimuli into electrical signals. These cells are primarily responsible for the initial process of vision and have two main types: rods and cones.

Rods are more numerous and are responsible for low-light vision or scotopic vision, enabling us to see in dimly lit conditions. They do not contribute to color vision but provide information about the shape and movement of objects.

Cones, on the other hand, are less numerous and are responsible for color vision and high-acuity vision or photopic vision. There are three types of cones, each sensitive to different wavelengths of light: short (S), medium (M), and long (L) wavelengths, which correspond to blue, green, and red, respectively. The combination of signals from these three types of cones allows us to perceive a wide range of colors.

Both rods and cones contain photopigments that consist of a protein called opsin and a light-sensitive chromophore called retinal. When light hits the photopigment, it triggers a series of chemical reactions that ultimately lead to the generation of an electrical signal that is transmitted to the brain via the optic nerve. This process enables us to see and perceive our visual world.

In the context of medicine, particularly in audiology and otolaryngology (ear, nose, and throat specialty), "noise" is defined as unwanted or disturbing sound in the environment that can interfere with communication, rest, sleep, or cognitive tasks. It can also refer to sounds that are harmful to hearing, such as loud machinery noises or music, which can cause noise-induced hearing loss if exposure is prolonged or at high enough levels.

In some medical contexts, "noise" may also refer to non-specific signals or interfering factors in diagnostic tests and measurements that can make it difficult to interpret results accurately.

C57BL/6 (C57 Black 6) is an inbred strain of laboratory mouse that is widely used in biomedical research. The term "inbred" refers to a strain of animals where matings have been carried out between siblings or other closely related individuals for many generations, resulting in a population that is highly homozygous at most genetic loci.

The C57BL/6 strain was established in 1920 by crossing a female mouse from the dilute brown (DBA) strain with a male mouse from the black strain. The resulting offspring were then interbred for many generations to create the inbred C57BL/6 strain.

C57BL/6 mice are known for their robust health, longevity, and ease of handling, making them a popular choice for researchers. They have been used in a wide range of biomedical research areas, including studies of cancer, immunology, neuroscience, cardiovascular disease, and metabolism.

One of the most notable features of the C57BL/6 strain is its sensitivity to certain genetic modifications, such as the introduction of mutations that lead to obesity or impaired glucose tolerance. This has made it a valuable tool for studying the genetic basis of complex diseases and traits.

Overall, the C57BL/6 inbred mouse strain is an important model organism in biomedical research, providing a valuable resource for understanding the genetic and molecular mechanisms underlying human health and disease.

Suppurative Otitis Media is a type of inner ear infection that involves the accumulation of pus (suppuration) in the middle ear space. It can be caused by a bacterial or viral infection and often results from a previous episode of acute otitis media, where fluid builds up behind the eardrum (tympanic membrane).

Suppurative Otitis Media can lead to complications such as hearing loss, damage to the inner ear structures, and spread of infection to nearby areas like the mastoid process or the brain. Treatment typically involves antibiotics to clear the infection and sometimes surgical intervention to drain the pus and relieve pressure on the eardrum.

Hearing aids are electronic devices designed to improve hearing and speech comprehension for individuals with hearing loss. They consist of a microphone, an amplifier, a speaker, and a battery. The microphone picks up sounds from the environment, the amplifier increases the volume of these sounds, and the speaker sends the amplified sound into the ear. Modern hearing aids often include additional features such as noise reduction, directional microphones, and wireless connectivity to smartphones or other devices. They are programmed to meet the specific needs of the user's hearing loss and can be adjusted for comfort and effectiveness. Hearing aids are available in various styles, including behind-the-ear (BTE), receiver-in-canal (RIC), in-the-ear (ITE), and completely-in-canal (CIC).

Stapes surgery, also known as stapedectomy or stapedotomy, is a surgical procedure performed to correct hearing loss caused by otosclerosis. Otosclerosis is a condition in which the stapes bone in the middle ear becomes fixed and unable to vibrate properly, leading to conductive hearing loss.

During stapes surgery, the surgeon makes an incision behind the ear and creates a small opening in the eardrum. The fixed stapes bone is then removed or modified, and a prosthetic device is inserted in its place to allow sound vibrations to be transmitted to the inner ear. In some cases, a piece of tissue or artificial material may be used to fill the space left by the removed bone.

Stapedectomy involves complete removal of the stapes bone, while stapedotomy involves making a small hole in the stapes bone and inserting a prosthetic device through it. Both procedures are typically performed on an outpatient basis and have a high success rate in restoring hearing. However, as with any surgical procedure, there are risks involved, including infection, permanent hearing loss, and balance problems.

Dichotic listening tests are a type of psychological and neurological assessment that measures the ability to process two different auditory stimuli presented simultaneously to each ear. In these tests, different speech sounds, tones, or other sounds are played at the same time, one to each ear, through headphones. The participant is then asked to repeat or identify the stimuli heard in each ear.

The test is designed to evaluate the functioning of the brain's hemispheres and their specialization for processing different types of information. Typically, the right ear is more efficient at sending information to the left hemisphere, which is specialized for language processing in most people. Therefore, speech sounds presented to the right ear are often identified more accurately than those presented to the left ear.

Dichotic listening tests can be used in various fields, including neuropsychology, audiology, and cognitive science, to assess brain function, laterality, attention, memory, and language processing abilities. These tests can also help identify any neurological impairments or deficits caused by injuries, diseases, or developmental disorders.

Carrier proteins, also known as transport proteins, are a type of protein that facilitates the movement of molecules across cell membranes. They are responsible for the selective and active transport of ions, sugars, amino acids, and other molecules from one side of the membrane to the other, against their concentration gradient. This process requires energy, usually in the form of ATP (adenosine triphosphate).

Carrier proteins have a specific binding site for the molecule they transport, and undergo conformational changes upon binding, which allows them to move the molecule across the membrane. Once the molecule has been transported, the carrier protein returns to its original conformation, ready to bind and transport another molecule.

Carrier proteins play a crucial role in maintaining the balance of ions and other molecules inside and outside of cells, and are essential for many physiological processes, including nerve impulse transmission, muscle contraction, and nutrient uptake.

Epithelium is the tissue that covers the outer surface of the body, lines the internal cavities and organs, and forms various glands. It is composed of one or more layers of tightly packed cells that have a uniform shape and size, and rest on a basement membrane. Epithelial tissues are avascular, meaning they do not contain blood vessels, and are supplied with nutrients by diffusion from the underlying connective tissue.

Epithelial cells perform a variety of functions, including protection, secretion, absorption, excretion, and sensation. They can be classified based on their shape and the number of cell layers they contain. The main types of epithelium are:

1. Squamous epithelium: composed of flat, scalelike cells that fit together like tiles on a roof. It forms the lining of blood vessels, air sacs in the lungs, and the outermost layer of the skin.
2. Cuboidal epithelium: composed of cube-shaped cells with equal height and width. It is found in glands, tubules, and ducts.
3. Columnar epithelium: composed of tall, rectangular cells that are taller than they are wide. It lines the respiratory, digestive, and reproductive tracts.
4. Pseudostratified epithelium: appears stratified or layered but is actually made up of a single layer of cells that vary in height. The nuclei of these cells appear at different levels, giving the tissue a stratified appearance. It lines the respiratory and reproductive tracts.
5. Transitional epithelium: composed of several layers of cells that can stretch and change shape to accommodate changes in volume. It is found in the urinary bladder and ureters.

Epithelial tissue provides a barrier between the internal and external environments, protecting the body from physical, chemical, and biological damage. It also plays a crucial role in maintaining homeostasis by regulating the exchange of substances between the body and its environment.

A phenotype is the physical or biochemical expression of an organism's genes, or the observable traits and characteristics resulting from the interaction of its genetic constitution (genotype) with environmental factors. These characteristics can include appearance, development, behavior, and resistance to disease, among others. Phenotypes can vary widely, even among individuals with identical genotypes, due to differences in environmental influences, gene expression, and genetic interactions.

Tinnitus is the perception of ringing or other sounds in the ears or head when no external sound is present. It can be described as a sensation of hearing sound even when no actual noise is present. The sounds perceived can vary widely, from a whistling, buzzing, hissing, swooshing, to a pulsating sound, and can be soft or loud.

Tinnitus is not a disease itself but a symptom that can result from a wide range of underlying causes, such as hearing loss, exposure to loud noises, ear infections, earwax blockage, head or neck injuries, circulatory system disorders, certain medications, and age-related hearing loss.

Tinnitus can be temporary or chronic, and it may affect one or both ears. While tinnitus is not usually a sign of a serious medical condition, it can significantly impact quality of life and interfere with daily activities, sleep, and concentration.

Submitochondrial particles, also known as "submitochondrial vesicles" or "inner membrane fragments," are small particles that consist of the inner mitochondrial membrane and the associated components. They are obtained through sonication or other methods of disrupting mitochondria, which results in breaking down the outer membrane while leaving the inner membrane intact. These particles can be used in various biochemical studies to investigate the structure, function, and composition of the inner mitochondrial membrane and its components, such as the electron transport chain and ATP synthase complexes.

Otosclerosis is a medical condition that affects the bones in the middle ear. It is characterized by the abnormal growth and hardening (sclerosis) of the otosclerotic bone near the stapes footplate, one of the tiny bones in the middle ear (ossicles). This abnormal bone growth can cause stiffness or fixation of the stapes bone, preventing it from vibrating properly and leading to conductive hearing loss. In some cases, otosclerosis may also result in sensorineural hearing loss due to involvement of the inner ear structures. The exact cause of otosclerosis is not fully understood, but it is believed to have a genetic component and can sometimes be associated with pregnancy. Treatment options for otosclerosis include hearing aids or surgical procedures like stapedectomy or stapedotomy to bypass or remove the affected bone and improve hearing.

Cochlear implantation is a surgical procedure in which a device called a cochlear implant is inserted into the inner ear (cochlea) of a person with severe to profound hearing loss. The implant consists of an external component, which includes a microphone, processor, and transmitter, and an internal component, which includes a receiver and electrode array.

The microphone picks up sounds from the environment and sends them to the processor, which analyzes and converts the sounds into electrical signals. These signals are then transmitted to the receiver, which stimulates the electrode array in the cochlea. The electrodes directly stimulate the auditory nerve fibers, bypassing the damaged hair cells in the inner ear that are responsible for normal hearing.

The brain interprets these electrical signals as sound, allowing the person to perceive and understand speech and other sounds. Cochlear implantation is typically recommended for people who do not benefit from traditional hearing aids and can significantly improve communication, quality of life, and social integration for those with severe to profound hearing loss.

Otorhinolaryngologic diseases, also known as ear, nose, and throat (ENT) diseases, refer to a group of medical conditions that affect the ears, nose, and/or throat. These specialized areas are closely related both anatomically and functionally, and disorders in one area can often have impacts on the others.

Here are some examples of otorhinolaryngologic diseases categorized by the affected area:

1. Otologic diseases - affecting the ear:
* Otitis media (ear infection)
* Otitis externa (swimmer's ear)
* Tinnitus (ringing in the ears)
* Hearing loss
* Meniere's disease (inner ear disorder causing vertigo, tinnitus, and hearing loss)
* Acoustic neuroma (noncancerous tumor on the vestibular nerve)
2. Rhinologic diseases - affecting the nose:
* Allergic rhinitis (hay fever)
* Non-allergic rhinitis
* Sinusitis (sinus infection)
* Deviated septum
* Nasal polyps
* Epistaxis (nosebleed)
3. Laryngologic diseases - affecting the throat and voice box:
* Laryngitis (inflammation of the larynx, causing hoarseness or voice loss)
* Vocal cord nodules or polyps
* Reflux laryngitis (acid reflux irritating the throat)
* Subglottic stenosis (narrowing of the airway below the vocal cords)
* Laryngeal cancer
4. Common otorhinolaryngologic diseases:
* Tonsillitis (inflammation of the tonsils, often causing sore throat and difficulty swallowing)
* Adenoiditis (inflammation of the adenoids, commonly seen in children)
* Obstructive sleep apnea (OSA, a disorder characterized by pauses in breathing during sleep)
* Pharyngitis (inflammation of the pharynx or throat)

Otorhinolaryngologists, also known as ENT specialists, diagnose and treat these conditions. They may use various methods such as physical examination, imaging studies, endoscopy, and laboratory tests to determine the best course of treatment for each individual patient.

The spiral ligament of the cochlea is a fibrous structure located in the inner ear, more specifically in the cochlea. It is part of the membranous labyrinth and helps to maintain the shape and tension of the cochlear duct, which is essential for hearing.

The spiral ligament is attached to the bony wall of the cochlea and runs along the entire length of the cochlear duct, spiraling around it in a snail-like fashion. It consists of an outer, highly vascularized fibrous layer (the fibrous cap) and an inner, more cellular layer (the avascular zone).

The spiral ligament plays a crucial role in sound transmission and perception by helping to maintain the mechanical properties of the cochlear duct. The tension on the basilar membrane, where the sensory hair cells are located, is regulated by the spiral ligament's stiffness and elasticity. This tension affects the vibration amplitude and frequency selectivity of the basilar membrane, which in turn influences how we perceive different sounds and pitches.

Damage to the spiral ligament can result in hearing loss or impairment due to disrupted sound transmission and perception.

Bilateral hearing loss refers to a type of hearing loss that affects both ears equally or to varying degrees. It can be further categorized into two types: sensorineural and conductive hearing loss. Sensorineural hearing loss occurs due to damage to the inner ear or nerve pathways from the inner ear to the brain, while conductive hearing loss happens when sound waves are not properly transmitted through the outer ear canal to the eardrum and middle ear bones. Bilateral hearing loss can result in difficulty understanding speech, localizing sounds, and may impact communication and quality of life. The diagnosis and management of bilateral hearing loss typically involve a comprehensive audiological evaluation and medical assessment to determine the underlying cause and appropriate treatment options.

Retinal Ganglion Cells (RGCs) are a type of neuron located in the innermost layer of the retina, the light-sensitive tissue at the back of the eye. These cells receive visual information from photoreceptors (rods and cones) via intermediate cells called bipolar cells. RGCs then send this visual information through their long axons to form the optic nerve, which transmits the signals to the brain for processing and interpretation as vision.

There are several types of RGCs, each with distinct morphological and functional characteristics. Some RGCs are specialized in detecting specific features of the visual scene, such as motion, contrast, color, or brightness. The diversity of RGCs allows for a rich and complex representation of the visual world in the brain.

Damage to RGCs can lead to various visual impairments, including loss of vision, reduced visual acuity, and altered visual fields. Conditions associated with RGC damage or degeneration include glaucoma, optic neuritis, ischemic optic neuropathy, and some inherited retinal diseases.

The stapedius is a small muscle in the middle ear. It is the smallest striated muscle in the human body, with a mass of about 0.6 mg. The stapedius muscle arises from a pyramidal eminence on the posterior wall of the tympanic cavity and inserts into the neck of the stapes (one of the three ossicles in the middle ear).

The main function of the stapedius muscle is to protect the inner ear from loud sounds. When contracted, it pulls the stapes away from the oval window, reducing its mobility and thus decreasing the transmission of sound vibrations to the inner ear. This reflex action, known as the stapedial reflex or acoustic reflex, helps to prevent damage to the inner ear from excessive noise levels.

The afferent limb of the stapedial reflex is carried by the vestibular branch of the vestibulocochlear nerve (cranial nerve VIII), while the efferent limb is mediated by the facial nerve (cranial nerve VII). The reflex can be elicited by loud sounds, vocalizations, or even mental arithmetic tasks.

'Escherichia coli' (E. coli) is a type of gram-negative, facultatively anaerobic, rod-shaped bacterium that commonly inhabits the intestinal tract of humans and warm-blooded animals. It is a member of the family Enterobacteriaceae and one of the most well-studied prokaryotic model organisms in molecular biology.

While most E. coli strains are harmless and even beneficial to their hosts, some serotypes can cause various forms of gastrointestinal and extraintestinal illnesses in humans and animals. These pathogenic strains possess virulence factors that enable them to colonize and damage host tissues, leading to diseases such as diarrhea, urinary tract infections, pneumonia, and sepsis.

E. coli is a versatile organism with remarkable genetic diversity, which allows it to adapt to various environmental niches. It can be found in water, soil, food, and various man-made environments, making it an essential indicator of fecal contamination and a common cause of foodborne illnesses. The study of E. coli has contributed significantly to our understanding of fundamental biological processes, including DNA replication, gene regulation, and protein synthesis.

A "knockout" mouse is a genetically engineered mouse in which one or more genes have been deleted or "knocked out" using molecular biology techniques. This allows researchers to study the function of specific genes and their role in various biological processes, as well as potential associations with human diseases. The mice are generated by introducing targeted DNA modifications into embryonic stem cells, which are then used to create a live animal. Knockout mice have been widely used in biomedical research to investigate gene function, disease mechanisms, and potential therapeutic targets.

An ossicular prosthesis is a medical device used to replace one or more of the small bones (ossicles) in the middle ear that are involved in hearing. These bones, known as the malleus, incus, and stapes, form a chain responsible for transmitting sound vibrations from the eardrum to the inner ear.

An ossicular prosthesis is typically made of biocompatible materials such as ceramic, plastic, or metal. The prosthesis is designed to bypass damaged or missing ossicles and reestablish the connection between the eardrum and the inner ear, thereby improving hearing function. Ossicular prostheses are often used in surgeries aimed at reconstructing the middle ear, such as tympanoplasty or stapedectomy, to treat various types of conductive hearing loss.

Bacterial proteins are a type of protein that are produced by bacteria as part of their structural or functional components. These proteins can be involved in various cellular processes, such as metabolism, DNA replication, transcription, and translation. They can also play a role in bacterial pathogenesis, helping the bacteria to evade the host's immune system, acquire nutrients, and multiply within the host.

Bacterial proteins can be classified into different categories based on their function, such as:

1. Enzymes: Proteins that catalyze chemical reactions in the bacterial cell.
2. Structural proteins: Proteins that provide structural support and maintain the shape of the bacterial cell.
3. Signaling proteins: Proteins that help bacteria to communicate with each other and coordinate their behavior.
4. Transport proteins: Proteins that facilitate the movement of molecules across the bacterial cell membrane.
5. Toxins: Proteins that are produced by pathogenic bacteria to damage host cells and promote infection.
6. Surface proteins: Proteins that are located on the surface of the bacterial cell and interact with the environment or host cells.

Understanding the structure and function of bacterial proteins is important for developing new antibiotics, vaccines, and other therapeutic strategies to combat bacterial infections.

A chick embryo refers to the developing organism that arises from a fertilized chicken egg. It is often used as a model system in biological research, particularly during the stages of development when many of its organs and systems are forming and can be easily observed and manipulated. The study of chick embryos has contributed significantly to our understanding of various aspects of developmental biology, including gastrulation, neurulation, organogenesis, and pattern formation. Researchers may use various techniques to observe and manipulate the chick embryo, such as surgical alterations, cell labeling, and exposure to drugs or other agents.

Protein transport, in the context of cellular biology, refers to the process by which proteins are actively moved from one location to another within or between cells. This is a crucial mechanism for maintaining proper cell function and regulation.

Intracellular protein transport involves the movement of proteins within a single cell. Proteins can be transported across membranes (such as the nuclear envelope, endoplasmic reticulum, Golgi apparatus, or plasma membrane) via specialized transport systems like vesicles and transport channels.

Intercellular protein transport refers to the movement of proteins from one cell to another, often facilitated by exocytosis (release of proteins in vesicles) and endocytosis (uptake of extracellular substances via membrane-bound vesicles). This is essential for communication between cells, immune response, and other physiological processes.

It's important to note that any disruption in protein transport can lead to various diseases, including neurological disorders, cancer, and metabolic conditions.

Labyrinthine fluids, also known as endolymph and perilymph, are fluids that fill the inner ear structures, specifically the bony labyrinth. The bony labyrinth is divided into two main parts: the cochlea, responsible for hearing, and the vestibular system, responsible for balance.

Endolymph is a clear, plasma-like fluid found within the membranous labyrinth, which is a series of interconnected tubes and sacs that lie inside the bony labyrinth. Endolymph plays a crucial role in the functioning of both the cochlea and vestibular system by creating an electrochemical gradient necessary for the conversion of mechanical sound vibrations into electrical signals in the cochlea, as well as facilitating the detection of head movements and maintaining balance in the vestibular system.

Perilymph, on the other hand, is a clear, colorless fluid that fills the space between the bony labyrinth and the membranous labyrinth. It is similar in composition to cerebrospinal fluid (CSF) and serves as a protective cushion for the delicate inner ear structures. Perilymph also helps maintain the electrochemical gradient required for sound transduction in the cochlea.

Disorders related to these labyrinthine fluids, such as endolymphatic hydrops or perilymph fistula, can lead to hearing and balance problems.

A "mutant strain of mice" in a medical context refers to genetically engineered mice that have specific genetic mutations introduced into their DNA. These mutations can be designed to mimic certain human diseases or conditions, allowing researchers to study the underlying biological mechanisms and test potential therapies in a controlled laboratory setting.

Mutant strains of mice are created through various techniques, including embryonic stem cell manipulation, gene editing technologies such as CRISPR-Cas9, and radiation-induced mutagenesis. These methods allow scientists to introduce specific genetic changes into the mouse genome, resulting in mice that exhibit altered physiological or behavioral traits.

These strains of mice are widely used in biomedical research because their short lifespan, small size, and high reproductive rate make them an ideal model organism for studying human diseases. Additionally, the mouse genome has been well-characterized, and many genetic tools and resources are available to researchers working with these animals.

Examples of mutant strains of mice include those that carry mutations in genes associated with cancer, neurodegenerative disorders, metabolic diseases, and immunological conditions. These mice provide valuable insights into the pathophysiology of human diseases and help advance our understanding of potential therapeutic interventions.

Auditory perception refers to the process by which the brain interprets and makes sense of the sounds we hear. It involves the recognition and interpretation of different frequencies, intensities, and patterns of sound waves that reach our ears through the process of hearing. This allows us to identify and distinguish various sounds such as speech, music, and environmental noises.

The auditory system includes the outer ear, middle ear, inner ear, and the auditory nerve, which transmits electrical signals to the brain's auditory cortex for processing and interpretation. Auditory perception is a complex process that involves multiple areas of the brain working together to identify and make sense of sounds in our environment.

Disorders or impairments in auditory perception can result in difficulties with hearing, understanding speech, and identifying environmental sounds, which can significantly impact communication, learning, and daily functioning.

I must clarify that the term "Guinea Pigs" is not typically used in medical definitions. However, in colloquial or informal language, it may refer to people who are used as the first to try out a new medical treatment or drug. This is known as being a "test subject" or "in a clinical trial."

In the field of scientific research, particularly in studies involving animals, guinea pigs are small rodents that are often used as experimental subjects due to their size, cost-effectiveness, and ease of handling. They are not actually pigs from Guinea, despite their name's origins being unclear. However, they do not exactly fit the description of being used in human medical experiments.

A base sequence in the context of molecular biology refers to the specific order of nucleotides in a DNA or RNA molecule. In DNA, these nucleotides are adenine (A), guanine (G), cytosine (C), and thymine (T). In RNA, uracil (U) takes the place of thymine. The base sequence contains genetic information that is transcribed into RNA and ultimately translated into proteins. It is the exact order of these bases that determines the genetic code and thus the function of the DNA or RNA molecule.

Auditory evoked potentials (AEP) are medical tests that measure the electrical activity in the brain in response to sound stimuli. These tests are often used to assess hearing function and neural processing in individuals, particularly those who cannot perform traditional behavioral hearing tests.

There are several types of AEP tests, including:

1. Brainstem Auditory Evoked Response (BAER) or Brainstem Auditory Evoked Potentials (BAEP): This test measures the electrical activity generated by the brainstem in response to a click or tone stimulus. It is often used to assess the integrity of the auditory nerve and brainstem pathways, and can help diagnose conditions such as auditory neuropathy and retrocochlear lesions.
2. Middle Latency Auditory Evoked Potentials (MLAEP): This test measures the electrical activity generated by the cortical auditory areas of the brain in response to a click or tone stimulus. It is often used to assess higher-level auditory processing, and can help diagnose conditions such as auditory processing disorders and central auditory dysfunction.
3. Long Latency Auditory Evoked Potentials (LLAEP): This test measures the electrical activity generated by the cortical auditory areas of the brain in response to a complex stimulus, such as speech. It is often used to assess language processing and cognitive function, and can help diagnose conditions such as learning disabilities and dementia.

Overall, AEP tests are valuable tools for assessing hearing and neural function in individuals who cannot perform traditional behavioral hearing tests or who have complex neurological conditions.

Electroretinography (ERG) is a medical test used to evaluate the functioning of the retina, which is the light-sensitive tissue located at the back of the eye. The test measures the electrical responses of the retina to light stimulation.

During the procedure, a special contact lens or electrode is placed on the surface of the eye to record the electrical activity generated by the retina's light-sensitive cells (rods and cones) and other cells in the retina. The test typically involves presenting different levels of flashes of light to the eye while the electrical responses are recorded.

The resulting ERG waveform provides information about the overall health and function of the retina, including the condition of the photoreceptors, the integrity of the inner retinal layers, and the health of the retinal ganglion cells. This test is often used to diagnose and monitor various retinal disorders, such as retinitis pigmentosa, macular degeneration, and diabetic retinopathy.

Scanning electron microscopy (SEM) is a type of electron microscopy that uses a focused beam of electrons to scan the surface of a sample and produce a high-resolution image. In SEM, a beam of electrons is scanned across the surface of a specimen, and secondary electrons are emitted from the sample due to interactions between the electrons and the atoms in the sample. These secondary electrons are then detected by a detector and used to create an image of the sample's surface topography. SEM can provide detailed images of the surface of a wide range of materials, including metals, polymers, ceramics, and biological samples. It is commonly used in materials science, biology, and electronics for the examination and analysis of surfaces at the micro- and nanoscale.

Animal disease models are specialized animals, typically rodents such as mice or rats, that have been genetically engineered or exposed to certain conditions to develop symptoms and physiological changes similar to those seen in human diseases. These models are used in medical research to study the pathophysiology of diseases, identify potential therapeutic targets, test drug efficacy and safety, and understand disease mechanisms.

The genetic modifications can include knockout or knock-in mutations, transgenic expression of specific genes, or RNA interference techniques. The animals may also be exposed to environmental factors such as chemicals, radiation, or infectious agents to induce the disease state.

Examples of animal disease models include:

1. Mouse models of cancer: Genetically engineered mice that develop various types of tumors, allowing researchers to study cancer initiation, progression, and metastasis.
2. Alzheimer's disease models: Transgenic mice expressing mutant human genes associated with Alzheimer's disease, which exhibit amyloid plaque formation and cognitive decline.
3. Diabetes models: Obese and diabetic mouse strains like the NOD (non-obese diabetic) or db/db mice, used to study the development of type 1 and type 2 diabetes, respectively.
4. Cardiovascular disease models: Atherosclerosis-prone mice, such as ApoE-deficient or LDLR-deficient mice, that develop plaque buildup in their arteries when fed a high-fat diet.
5. Inflammatory bowel disease models: Mice with genetic mutations affecting intestinal barrier function and immune response, such as IL-10 knockout or SAMP1/YitFc mice, which develop colitis.

Animal disease models are essential tools in preclinical research, but it is important to recognize their limitations. Differences between species can affect the translatability of results from animal studies to human patients. Therefore, researchers must carefully consider the choice of model and interpret findings cautiously when applying them to human diseases.

Gerbillinae is a subfamily of rodents that includes gerbils, jirds, and sand rats. These small mammals are primarily found in arid regions of Africa and Asia. They are characterized by their long hind legs, which they use for hopping, and their long, thin tails. Some species have adapted to desert environments by developing specialized kidneys that allow them to survive on minimal water intake.

Confocal microscopy is a powerful imaging technique used in medical and biological research to obtain high-resolution, contrast-rich images of thick samples. This super-resolution technology provides detailed visualization of cellular structures and processes at various depths within a specimen.

In confocal microscopy, a laser beam focused through a pinhole illuminates a small spot within the sample. The emitted fluorescence or reflected light from this spot is then collected by a detector, passing through a second pinhole that ensures only light from the focal plane reaches the detector. This process eliminates out-of-focus light, resulting in sharp images with improved contrast compared to conventional widefield microscopy.

By scanning the laser beam across the sample in a raster pattern and collecting fluorescence at each point, confocal microscopy generates optical sections of the specimen. These sections can be combined to create three-dimensional reconstructions, allowing researchers to study cellular architecture and interactions within complex tissues.

Confocal microscopy has numerous applications in medical research, including studying protein localization, tracking intracellular dynamics, analyzing cell morphology, and investigating disease mechanisms at the cellular level. Additionally, it is widely used in clinical settings for diagnostic purposes, such as analyzing skin lesions or detecting pathogens in patient samples.

Messenger RNA (mRNA) is a type of RNA (ribonucleic acid) that carries genetic information copied from DNA in the form of a series of three-base code "words," each of which specifies a particular amino acid. This information is used by the cell's machinery to construct proteins, a process known as translation. After being transcribed from DNA, mRNA travels out of the nucleus to the ribosomes in the cytoplasm where protein synthesis occurs. Once the protein has been synthesized, the mRNA may be degraded and recycled. Post-transcriptional modifications can also occur to mRNA, such as alternative splicing and addition of a 5' cap and a poly(A) tail, which can affect its stability, localization, and translation efficiency.

A mammalian embryo is the developing offspring of a mammal, from the time of implantation of the fertilized egg (blastocyst) in the uterus until the end of the eighth week of gestation. During this period, the embryo undergoes rapid cell division and organ differentiation to form a complex structure with all the major organs and systems in place. This stage is followed by fetal development, which continues until birth. The study of mammalian embryos is important for understanding human development, evolution, and reproductive biology.

Cochlear implants are medical devices that are surgically implanted in the inner ear to help restore hearing in individuals with severe to profound hearing loss. These devices bypass the damaged hair cells in the inner ear and directly stimulate the auditory nerve, allowing the brain to interpret sound signals. Cochlear implants consist of two main components: an external processor that picks up and analyzes sounds from the environment, and an internal receiver/stimulator that receives the processed information and sends electrical impulses to the auditory nerve. The resulting patterns of electrical activity are then perceived as sound by the brain. Cochlear implants can significantly improve communication abilities, language development, and overall quality of life for individuals with profound hearing loss.

Edema is the medical term for swelling caused by excess fluid accumulation in the body tissues. It can affect any part of the body, but it's most commonly noticed in the hands, feet, ankles, and legs. Edema can be a symptom of various underlying medical conditions, such as heart failure, kidney disease, liver disease, or venous insufficiency.

The swelling occurs when the capillaries leak fluid into the surrounding tissues, causing them to become swollen and puffy. The excess fluid can also collect in the cavities of the body, leading to conditions such as pleural effusion (fluid around the lungs) or ascites (fluid in the abdominal cavity).

The severity of edema can vary from mild to severe, and it may be accompanied by other symptoms such as skin discoloration, stiffness, and pain. Treatment for edema depends on the underlying cause and may include medications, lifestyle changes, or medical procedures.

Dyneins are a type of motor protein that play an essential role in the movement of cellular components and structures within eukaryotic cells. They are responsible for generating force and motion along microtubules, which are critical components of the cell's cytoskeleton. Dyneins are involved in various cellular processes, including intracellular transport, organelle positioning, and cell division.

There are several types of dyneins, but the two main categories are cytoplasmic dyneins and axonemal dyneins. Cytoplasmic dyneins are responsible for moving various cargoes, such as vesicles, organelles, and mRNA complexes, toward the minus-end of microtubules, which is usually located near the cell center. Axonemal dyneins, on the other hand, are found in cilia and flagella and are responsible for their movement by sliding adjacent microtubules past each other.

Dyneins consist of multiple subunits, including heavy chains, intermediate chains, light-intermediate chains, and light chains. The heavy chains contain the motor domain that binds to microtubules and hydrolyzes ATP to generate force. Dysfunction in dynein proteins has been linked to various human diseases, such as neurodevelopmental disorders, ciliopathies, and cancer.

The vestibular aqueduct is a bony canal that runs from the inner ear to the brain. It contains a membranous duct, called the endolymphatic duct, which is filled with a fluid called endolymph. The vestibular aqueduct plays a role in the maintenance of balance and hearing by regulating the pressure and composition of the endolymph. Abnormalities or damage to the vestibular aqueduct can lead to conditions such as endolymphatic hydrops, which can cause symptoms like vertigo, dizziness, and hearing loss.

In the context of medicine and physiology, vibration refers to the mechanical oscillation of a physical body or substance with a periodic back-and-forth motion around an equilibrium point. This motion can be produced by external forces or internal processes within the body.

Vibration is often measured in terms of frequency (the number of cycles per second) and amplitude (the maximum displacement from the equilibrium position). In clinical settings, vibration perception tests are used to assess peripheral nerve function and diagnose conditions such as neuropathy.

Prolonged exposure to whole-body vibration or hand-transmitted vibration in certain occupational settings can also have adverse health effects, including hearing loss, musculoskeletal disorders, and vascular damage.

Photoreceptor cells are specialized neurons in the retina of the eye that convert light into electrical signals. These cells consist of two types: rods and cones. Rods are responsible for vision at low light levels and provide black-and-white, peripheral, and motion sensitivity. Cones are active at higher light levels and are capable of color discrimination and fine detail vision. Both types of photoreceptor cells contain light-sensitive pigments that undergo chemical changes when exposed to light, triggering a series of electrical signals that ultimately reach the brain and contribute to visual perception.

Cell differentiation is the process by which a less specialized cell, or stem cell, becomes a more specialized cell type with specific functions and structures. This process involves changes in gene expression, which are regulated by various intracellular signaling pathways and transcription factors. Differentiation results in the development of distinct cell types that make up tissues and organs in multicellular organisms. It is a crucial aspect of embryonic development, tissue repair, and maintenance of homeostasis in the body.

In medical terms, pressure is defined as the force applied per unit area on an object or body surface. It is often measured in millimeters of mercury (mmHg) in clinical settings. For example, blood pressure is the force exerted by circulating blood on the walls of the arteries and is recorded as two numbers: systolic pressure (when the heart beats and pushes blood out) and diastolic pressure (when the heart rests between beats).

Pressure can also refer to the pressure exerted on a wound or incision to help control bleeding, or the pressure inside the skull or spinal canal. High or low pressure in different body systems can indicate various medical conditions and require appropriate treatment.

I'm sorry for any confusion, but "London" is a place and not a medical term or condition. It is the capital city and largest metropolitan area in both England and the United Kingdom. If you have any questions related to medical definitions or health-related topics, I would be happy to help!

Mitochondrial ADP/ATP translocases, also known as adenine nucleotide translocators (ANT), are a group of proteins located in the inner mitochondrial membrane that play a crucial role in cellular energy production. These translocases facilitate the exchange of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) across the mitochondrial membrane, which is essential for oxidative phosphorylation and thus, energy homeostasis in the cell.

In more detail, during oxidative phosphorylation, ATP is produced within the mitochondria as a result of the electron transport chain's activity. This ATP must be exported to the cytosol for use by the cell's various processes. Simultaneously, the mitochondria need a continuous supply of ADP to sustain the production of ATP. The mitochondrial ADP/ATP translocases facilitate this exchange, allowing for the import of ADP into the mitochondria and the export of ATP to the cytosol.

There are multiple isoforms of the ADP/ATP translocase in humans (ANT1, ANT2, ANT3, and ANT4), encoded by different genes, with varying tissue distributions and functions. Dysfunction of these translocases has been implicated in several pathological conditions, including neurodegenerative diseases, ischemia-reperfusion injury, and cancer.

"Newborn animals" refers to the very young offspring of animals that have recently been born. In medical terminology, newborns are often referred to as "neonates," and they are classified as such from birth until about 28 days of age. During this time period, newborn animals are particularly vulnerable and require close monitoring and care to ensure their survival and healthy development.

The specific needs of newborn animals can vary widely depending on the species, but generally, they require warmth, nutrition, hydration, and protection from harm. In many cases, newborns are unable to regulate their own body temperature or feed themselves, so they rely heavily on their mothers for care and support.

In medical settings, newborn animals may be examined and treated by veterinarians to ensure that they are healthy and receiving the care they need. This can include providing medical interventions such as feeding tubes, antibiotics, or other treatments as needed to address any health issues that arise. Overall, the care and support of newborn animals is an important aspect of animal medicine and conservation efforts.

Sensory ganglia are clusters of nerve cell bodies located outside the central nervous system (the brain and spinal cord). They are primarily associated with sensory neurons, which are responsible for transmitting sensory information from various parts of the body to the central nervous system.

In humans, there are two main types of sensory ganglia: dorsal root ganglia and cranial nerve ganglia. Dorsal root ganglia are located along the spinal cord and contain the cell bodies of sensory neurons that innervate the skin, muscles, joints, and other tissues of the body. These neurons transmit information about touch, temperature, pain, and proprioception (the sense of the position and movement of the body).

Cranial nerve ganglia are associated with the cranial nerves, which are responsible for transmitting sensory information from the head and neck to the brain. For example, the trigeminal ganglion is a cranial nerve ganglion that contains the cell bodies of neurons that transmit sensory information from the face, mouth, and other structures of the head.

Overall, sensory ganglia play a critical role in our ability to perceive and interact with the world around us by transmitting important sensory information to the brain for processing.

Acoustics is a branch of physics that deals with the study of sound, its production, transmission, and effects. In a medical context, acoustics may refer to the use of sound waves in medical procedures such as:

1. Diagnostic ultrasound: This technique uses high-frequency sound waves to create images of internal organs and tissues. It is commonly used during pregnancy to monitor fetal development, but it can also be used to diagnose a variety of medical conditions, including heart disease, cancer, and musculoskeletal injuries.
2. Therapeutic ultrasound: This technique uses low-frequency sound waves to promote healing and reduce pain and inflammation in muscles, tendons, and ligaments. It is often used to treat soft tissue injuries, arthritis, and other musculoskeletal conditions.
3. Otology: Acoustics also plays a crucial role in the field of otology, which deals with the study and treatment of hearing and balance disorders. The shape, size, and movement of the outer ear, middle ear, and inner ear all affect how sound waves are transmitted and perceived. Abnormalities in any of these structures can lead to hearing loss, tinnitus, or balance problems.

In summary, acoustics is an important field of study in medicine that has applications in diagnosis, therapy, and the understanding of various medical conditions related to sound and hearing.

The vestibulocochlear nerve, also known as the 8th cranial nerve, is responsible for transmitting sound and balance information from the inner ear to the brain. Vestibulocochlear nerve diseases refer to conditions that affect this nerve and can result in hearing loss, vertigo, and balance problems.

These diseases can be caused by various factors, including genetics, infection, trauma, tumors, or degeneration. Some examples of vestibulocochlear nerve diseases include:

1. Vestibular neuritis: an inner ear infection that causes severe vertigo, nausea, and balance problems.
2. Labyrinthitis: an inner ear infection that affects both the vestibular and cochlear nerves, causing vertigo, hearing loss, and tinnitus.
3. Acoustic neuroma: a benign tumor that grows on the vestibulocochlear nerve, causing hearing loss, tinnitus, and balance problems.
4. Meniere's disease: a inner ear disorder that causes vertigo, hearing loss, tinnitus, and a feeling of fullness in the ear.
5. Ototoxicity: damage to the inner ear caused by certain medications or chemicals that can result in hearing loss and balance problems.
6. Vestibular migraine: a type of migraine that is associated with vertigo, dizziness, and balance problems.

Treatment for vestibulocochlear nerve diseases varies depending on the specific condition and its severity. It may include medication, physical therapy, surgery, or a combination of these approaches.

Homeodomain proteins are a group of transcription factors that play crucial roles in the development and differentiation of cells in animals and plants. They are characterized by the presence of a highly conserved DNA-binding domain called the homeodomain, which is typically about 60 amino acids long. The homeodomain consists of three helices, with the third helix responsible for recognizing and binding to specific DNA sequences.

Homeodomain proteins are involved in regulating gene expression during embryonic development, tissue maintenance, and organismal growth. They can act as activators or repressors of transcription, depending on the context and the presence of cofactors. Mutations in homeodomain proteins have been associated with various human diseases, including cancer, congenital abnormalities, and neurological disorders.

Some examples of homeodomain proteins include PAX6, which is essential for eye development, HOX genes, which are involved in body patterning, and NANOG, which plays a role in maintaining pluripotency in stem cells.

Sudden hearing loss, also known as sudden sensorineural hearing loss (SSHL), is a type of hearing impairment that occurs suddenly or over a period of up to 3 days. It is typically defined as a hearing reduction of at least 30 decibels in three connected frequencies. The cause of SSHL is often unknown, but it can be associated with viral infections, trauma, neurological disorders, and exposure to certain ototoxic medications. In some cases, the hearing loss may resolve on its own, but prompt medical evaluation and treatment are recommended to improve the chances of recovery. Treatment options include corticosteroids, antiviral medication, and hyperbaric oxygen therapy.

Tertiary protein structure refers to the three-dimensional arrangement of all the elements (polypeptide chains) of a single protein molecule. It is the highest level of structural organization and results from interactions between various side chains (R groups) of the amino acids that make up the protein. These interactions, which include hydrogen bonds, ionic bonds, van der Waals forces, and disulfide bridges, give the protein its unique shape and stability, which in turn determines its function. The tertiary structure of a protein can be stabilized by various factors such as temperature, pH, and the presence of certain ions. Any changes in these factors can lead to denaturation, where the protein loses its tertiary structure and thus its function.

Aquaporin 2 (AQP2) is a type of aquaporin, which is a water channel protein found in the membranes of cells. Specifically, AQP2 is located in the principal cells of the collecting ducts in the kidneys. It plays a crucial role in regulating water reabsorption and urine concentration by facilitating the movement of water across the cell membrane in response to the hormone vasopressin (also known as antidiuretic hormone). When vasopressin binds to receptors on the cell surface, it triggers a cascade of intracellular signals that lead to the translocation of AQP2 water channels from intracellular vesicles to the apical membrane. This increases the permeability of the apical membrane to water, allowing for efficient reabsorption of water and concentration of urine. Dysfunction in AQP2 has been implicated in various kidney disorders, such as nephrogenic diabetes insipidus.

'Escherichia coli (E. coli) proteins' refer to the various types of proteins that are produced and expressed by the bacterium Escherichia coli. These proteins play a critical role in the growth, development, and survival of the organism. They are involved in various cellular processes such as metabolism, DNA replication, transcription, translation, repair, and regulation.

E. coli is a gram-negative, facultative anaerobe that is commonly found in the intestines of warm-blooded organisms. It is widely used as a model organism in scientific research due to its well-studied genetics, rapid growth, and ability to be easily manipulated in the laboratory. As a result, many E. coli proteins have been identified, characterized, and studied in great detail.

Some examples of E. coli proteins include enzymes involved in carbohydrate metabolism such as lactase, sucrase, and maltose; proteins involved in DNA replication such as the polymerases, single-stranded binding proteins, and helicases; proteins involved in transcription such as RNA polymerase and sigma factors; proteins involved in translation such as ribosomal proteins, tRNAs, and aminoacyl-tRNA synthetases; and regulatory proteins such as global regulators, two-component systems, and transcription factors.

Understanding the structure, function, and regulation of E. coli proteins is essential for understanding the basic biology of this important organism, as well as for developing new strategies for combating bacterial infections and improving industrial processes involving bacteria.

In medical terms, the skin is the largest organ of the human body. It consists of two main layers: the epidermis (outer layer) and dermis (inner layer), as well as accessory structures like hair follicles, sweat glands, and oil glands. The skin plays a crucial role in protecting us from external factors such as bacteria, viruses, and environmental hazards, while also regulating body temperature and enabling the sense of touch.

Membrane potential is the electrical potential difference across a cell membrane, typically for excitable cells such as nerve and muscle cells. It is the difference in electric charge between the inside and outside of a cell, created by the selective permeability of the cell membrane to different ions. The resting membrane potential of a typical animal cell is around -70 mV, with the interior being negative relative to the exterior. This potential is generated and maintained by the active transport of ions across the membrane, primarily through the action of the sodium-potassium pump. Membrane potentials play a crucial role in many physiological processes, including the transmission of nerve impulses and the contraction of muscle cells.

Vertigo is a specific type of dizziness characterized by the sensation that you or your surroundings are spinning or moving, even when you're perfectly still. It's often caused by issues with the inner ear or the balance-sensing systems of the body. Vertigo can be brought on by various conditions, such as benign paroxysmal positional vertigo (BPPV), labyrinthitis, vestibular neuritis, Meniere's disease, and migraines. In some cases, vertigo may also result from head or neck injuries, brain disorders like stroke or tumors, or certain medications. Treatment for vertigo depends on the underlying cause and can include specific exercises, medication, or surgery in severe cases.

The semicircular ducts are part of the vestibular system in the inner ear that contributes to maintaining balance and spatial orientation. They are fluid-filled tubes, shaped like a candy cane, and arranged roughly at right angles to each other. There is one horizontal duct (the lateral semicircular duct) and two vertical ducts (anterior and posterior semicircular ducts).

The semicircular ducts detect rotational movements of the head by sensing the movement of fluid within them, which in turn stimulates hair cells that transmit signals to the brain. These structures play a crucial role in our ability to maintain equilibrium and coordinate head movements with body posture during various activities like walking, running, or changing direction quickly.

The lateral line system is a sensory organ found in aquatic animals, such as fish and some aquatic amphibians. It is a series of fluid-filled canals and sensory cells that run along the sides of the body, head, and fins. These sensory cells are called neuromasts and contain hair cells that respond to vibrations and water movements. The lateral line system helps these animals detect movement, pressure changes, and vibrations in their aquatic environment, which aids in schooling behavior, prey detection, and avoiding predators.

The cochlear aqueduct is a small canal that runs from the inner ear to the brain. It contains a fluid called perilymph, which helps to protect and cushion the structures of the inner ear. The cochlear aqueduct also serves as a passageway for the endolymphatic duct and sac, which are involved in the regulation of the inner ear's fluid balance.

Anomalies or abnormalities of the cochlear aqueduct can lead to hearing problems, balance disorders, and other symptoms. For example, a large or dilated cochlear aqueduct may be associated with an increased risk of meningitis, a serious infection of the membranes surrounding the brain and spinal cord. In some cases, surgical closure of the cochlear aqueduct may be necessary to prevent recurrent meningitis or other complications.

Protein binding, in the context of medical and biological sciences, refers to the interaction between a protein and another molecule (known as the ligand) that results in a stable complex. This process is often reversible and can be influenced by various factors such as pH, temperature, and concentration of the involved molecules.

In clinical chemistry, protein binding is particularly important when it comes to drugs, as many of them bind to proteins (especially albumin) in the bloodstream. The degree of protein binding can affect a drug's distribution, metabolism, and excretion, which in turn influence its therapeutic effectiveness and potential side effects.

Protein-bound drugs may be less available for interaction with their target tissues, as only the unbound or "free" fraction of the drug is active. Therefore, understanding protein binding can help optimize dosing regimens and minimize adverse reactions.

In the context of medicine and pharmacology, "kinetics" refers to the study of how a drug moves throughout the body, including its absorption, distribution, metabolism, and excretion (often abbreviated as ADME). This field is called "pharmacokinetics."

1. Absorption: This is the process of a drug moving from its site of administration into the bloodstream. Factors such as the route of administration (e.g., oral, intravenous, etc.), formulation, and individual physiological differences can affect absorption.

2. Distribution: Once a drug is in the bloodstream, it gets distributed throughout the body to various tissues and organs. This process is influenced by factors like blood flow, protein binding, and lipid solubility of the drug.

3. Metabolism: Drugs are often chemically modified in the body, typically in the liver, through processes known as metabolism. These changes can lead to the formation of active or inactive metabolites, which may then be further distributed, excreted, or undergo additional metabolic transformations.

4. Excretion: This is the process by which drugs and their metabolites are eliminated from the body, primarily through the kidneys (urine) and the liver (bile).

Understanding the kinetics of a drug is crucial for determining its optimal dosing regimen, potential interactions with other medications or foods, and any necessary adjustments for special populations like pediatric or geriatric patients, or those with impaired renal or hepatic function.

Cilia are tiny, hair-like structures that protrude from the surface of many types of cells in the body. They are composed of a core bundle of microtubules surrounded by a protein matrix and are covered with a membrane. Cilia are involved in various cellular functions, including movement of fluid or mucus across the cell surface, detection of external stimuli, and regulation of signaling pathways.

There are two types of cilia: motile and non-motile. Motile cilia are able to move in a coordinated manner to propel fluids or particles across a surface, such as those found in the respiratory tract and reproductive organs. Non-motile cilia, also known as primary cilia, are present on most cells in the body and serve as sensory organelles that detect chemical and mechanical signals from the environment.

Defects in cilia structure or function can lead to a variety of diseases, collectively known as ciliopathies. These conditions can affect multiple organs and systems in the body, including the brain, kidneys, liver, and eyes. Examples of ciliopathies include polycystic kidney disease, Bardet-Biedl syndrome, and Meckel-Gruber syndrome.

Transcription factors are proteins that play a crucial role in regulating gene expression by controlling the transcription of DNA to messenger RNA (mRNA). They function by binding to specific DNA sequences, known as response elements, located in the promoter region or enhancer regions of target genes. This binding can either activate or repress the initiation of transcription, depending on the properties and interactions of the particular transcription factor. Transcription factors often act as part of a complex network of regulatory proteins that determine the precise spatiotemporal patterns of gene expression during development, differentiation, and homeostasis in an organism.

Regeneration in a medical context refers to the process of renewal, restoration, and growth that replaces damaged or missing cells, tissues, organs, or even whole limbs in some organisms. This complex biological process involves various cellular and molecular mechanisms, such as cell proliferation, differentiation, and migration, which work together to restore the structural and functional integrity of the affected area.

In human medicine, regeneration has attracted significant interest due to its potential therapeutic applications in treating various conditions, including degenerative diseases, trauma, and congenital disorders. Researchers are actively studying the underlying mechanisms of regeneration in various model organisms to develop novel strategies for promoting tissue repair and regeneration in humans.

Examples of regeneration in human medicine include liver regeneration after partial hepatectomy, where the remaining liver lobes can grow back to their original size within weeks, and skin wound healing, where keratinocytes migrate and proliferate to close the wound and restore the epidermal layer. However, the regenerative capacity of humans is limited compared to some other organisms, such as planarians and axolotls, which can regenerate entire body parts or even their central nervous system.

"Saccharomyces cerevisiae" is not typically considered a medical term, but it is a scientific name used in the field of microbiology. It refers to a species of yeast that is commonly used in various industrial processes, such as baking and brewing. It's also widely used in scientific research due to its genetic tractability and eukaryotic cellular organization.

However, it does have some relevance to medical fields like medicine and nutrition. For example, certain strains of S. cerevisiae are used as probiotics, which can provide health benefits when consumed. They may help support gut health, enhance the immune system, and even assist in the digestion of certain nutrients.

In summary, "Saccharomyces cerevisiae" is a species of yeast with various industrial and potential medical applications.

"Cells, cultured" is a medical term that refers to cells that have been removed from an organism and grown in controlled laboratory conditions outside of the body. This process is called cell culture and it allows scientists to study cells in a more controlled and accessible environment than they would have inside the body. Cultured cells can be derived from a variety of sources, including tissues, organs, or fluids from humans, animals, or cell lines that have been previously established in the laboratory.

Cell culture involves several steps, including isolation of the cells from the tissue, purification and characterization of the cells, and maintenance of the cells in appropriate growth conditions. The cells are typically grown in specialized media that contain nutrients, growth factors, and other components necessary for their survival and proliferation. Cultured cells can be used for a variety of purposes, including basic research, drug development and testing, and production of biological products such as vaccines and gene therapies.

It is important to note that cultured cells may behave differently than they do in the body, and results obtained from cell culture studies may not always translate directly to human physiology or disease. Therefore, it is essential to validate findings from cell culture experiments using additional models and ultimately in clinical trials involving human subjects.

A "reflex, acoustic" is not a standard medical term. However, it seems like you might be looking for a definition of the "acoustic reflex." The acoustic reflex is an involuntary muscle contraction that occurs in the middle ear in response to loud sounds. This reflex helps protect the inner ear from damage caused by high-intensity sounds.

When a loud sound reaches the ear, it stimulates the stapedius muscle in the middle ear, which then contracts and causes the stapes bone (one of the three bones in the middle ear) to become stiffer. This stiffening reduces the amount of sound that is transmitted to the inner ear, thus protecting it from potential harm.

The acoustic reflex can be measured using a device called an impedance audiometer, which measures changes in the pressure within the ear canal caused by muscle contraction during the reflex. This measurement provides valuable information for diagnosing and monitoring various hearing and balance disorders.

Signal transduction is the process by which a cell converts an extracellular signal, such as a hormone or neurotransmitter, into an intracellular response. This involves a series of molecular events that transmit the signal from the cell surface to the interior of the cell, ultimately resulting in changes in gene expression, protein activity, or metabolism.

The process typically begins with the binding of the extracellular signal to a receptor located on the cell membrane. This binding event activates the receptor, which then triggers a cascade of intracellular signaling molecules, such as second messengers, protein kinases, and ion channels. These molecules amplify and propagate the signal, ultimately leading to the activation or inhibition of specific cellular responses.

Signal transduction pathways are highly regulated and can be modulated by various factors, including other signaling molecules, post-translational modifications, and feedback mechanisms. Dysregulation of these pathways has been implicated in a variety of diseases, including cancer, diabetes, and neurological disorders.

"Cell count" is a medical term that refers to the process of determining the number of cells present in a given volume or sample of fluid or tissue. This can be done through various laboratory methods, such as counting individual cells under a microscope using a specialized grid called a hemocytometer, or using automated cell counters that use light scattering and electrical impedance techniques to count and classify different types of cells.

Cell counts are used in a variety of medical contexts, including hematology (the study of blood and blood-forming tissues), microbiology (the study of microscopic organisms), and pathology (the study of diseases and their causes). For example, a complete blood count (CBC) is a routine laboratory test that includes a white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin level, hematocrit value, and platelet count. Abnormal cell counts can indicate the presence of various medical conditions, such as infections, anemia, or leukemia.

In medical terms, membranes refer to thin layers of tissue that cover or line various structures in the body. They are composed of connective tissue and epithelial cells, and they can be found lining the outer surface of the body, internal organs, blood vessels, and nerves. There are several types of membranes in the human body, including:

1. Serous Membranes: These membranes line the inside of body cavities and cover the organs contained within them. They produce a lubricating fluid that reduces friction between the organ and the cavity wall. Examples include the pleura (lungs), pericardium (heart), and peritoneum (abdominal cavity).
2. Mucous Membranes: These membranes line the respiratory, gastrointestinal, and genitourinary tracts, as well as the inner surface of the eyelids and the nasal passages. They produce mucus to trap particles, bacteria, and other substances, which helps protect the body from infection.
3. Synovial Membranes: These membranes line the joint cavities and produce synovial fluid, which lubricates the joints and allows for smooth movement.
4. Meninges: These are three layers of membranes that cover and protect the brain and spinal cord. They include the dura mater (outermost layer), arachnoid mater (middle layer), and pia mater (innermost layer).
5. Amniotic Membrane: This is a thin, transparent membrane that surrounds and protects the fetus during pregnancy. It produces amniotic fluid, which provides a cushion for the developing baby and helps regulate its temperature.

Contact dermatitis is a type of inflammation of the skin that occurs when it comes into contact with a substance that the individual has developed an allergic reaction to or that causes irritation. It can be divided into two main types: allergic contact dermatitis and irritant contact dermatitis.

Allergic contact dermatitis is caused by an immune system response to a substance, known as an allergen, which the individual has become sensitized to. When the skin comes into contact with this allergen, it triggers an immune reaction that results in inflammation and characteristic symptoms such as redness, swelling, itching, and blistering. Common allergens include metals (such as nickel), rubber, medications, fragrances, and cosmetics.

Irritant contact dermatitis, on the other hand, is caused by direct damage to the skin from a substance that is inherently irritating or corrosive. This can occur after exposure to strong acids, alkalis, solvents, or even prolonged exposure to milder irritants like water or soap. Symptoms of irritant contact dermatitis include redness, pain, burning, and dryness at the site of contact.

The treatment for contact dermatitis typically involves avoiding further exposure to the allergen or irritant, as well as managing symptoms with topical corticosteroids, antihistamines, or other medications as needed. In some cases, patch testing may be performed to identify specific allergens that are causing the reaction.

Retinal diseases refer to a group of conditions that affect the retina, which is the light-sensitive tissue located at the back of the eye. The retina is responsible for converting light into electrical signals that are sent to the brain and interpreted as visual images. Retinal diseases can cause vision loss or even blindness, depending on their severity and location in the retina.

Some common retinal diseases include:

1. Age-related macular degeneration (AMD): A progressive disease that affects the central part of the retina called the macula, causing blurred or distorted vision.
2. Diabetic retinopathy: A complication of diabetes that can damage the blood vessels in the retina, leading to vision loss.
3. Retinal detachment: A serious condition where the retina becomes separated from its underlying tissue, requiring immediate medical attention.
4. Macular edema: Swelling or thickening of the macula due to fluid accumulation, which can cause blurred vision.
5. Retinitis pigmentosa: A group of inherited eye disorders that affect the retina's ability to respond to light, causing progressive vision loss.
6. Macular hole: A small break in the macula that can cause distorted or blurry vision.
7. Retinal vein occlusion: Blockage of the retinal veins that can lead to bleeding, swelling, and potential vision loss.

Treatment for retinal diseases varies depending on the specific condition and its severity. Some treatments include medication, laser therapy, surgery, or a combination of these options. Regular eye exams are essential for early detection and treatment of retinal diseases.

Nerve tissue proteins are specialized proteins found in the nervous system that provide structural and functional support to nerve cells, also known as neurons. These proteins include:

1. Neurofilaments: These are type IV intermediate filaments that provide structural support to neurons and help maintain their shape and size. They are composed of three subunits - NFL (light), NFM (medium), and NFH (heavy).

2. Neuronal Cytoskeletal Proteins: These include tubulins, actins, and spectrins that provide structural support to the neuronal cytoskeleton and help maintain its integrity.

3. Neurotransmitter Receptors: These are specialized proteins located on the postsynaptic membrane of neurons that bind neurotransmitters released by presynaptic neurons, triggering a response in the target cell.

4. Ion Channels: These are transmembrane proteins that regulate the flow of ions across the neuronal membrane and play a crucial role in generating and transmitting electrical signals in neurons.

5. Signaling Proteins: These include enzymes, receptors, and adaptor proteins that mediate intracellular signaling pathways involved in neuronal development, differentiation, survival, and death.

6. Adhesion Proteins: These are cell surface proteins that mediate cell-cell and cell-matrix interactions, playing a crucial role in the formation and maintenance of neural circuits.

7. Extracellular Matrix Proteins: These include proteoglycans, laminins, and collagens that provide structural support to nerve tissue and regulate neuronal migration, differentiation, and survival.

Electron Transport Complex IV is also known as Cytochrome c oxidase. It is the last complex in the electron transport chain, located in the inner mitochondrial membrane of eukaryotic cells and the plasma membrane of prokaryotic cells. This complex contains 13 subunits, two heme groups (a and a3), and three copper centers (A, B, and C).

In the electron transport chain, Complex IV receives electrons from cytochrome c and transfers them to molecular oxygen, reducing it to water. This process is accompanied by the pumping of protons across the membrane, contributing to the generation of a proton gradient that drives ATP synthesis via ATP synthase (Complex V). The overall reaction catalyzed by Complex IV can be summarized as follows:

4e- + 4H+ + O2 → 2H2O

Defects in Cytochrome c oxidase can lead to various diseases, including mitochondrial encephalomyopathies and neurodegenerative disorders.

Sprague-Dawley rats are a strain of albino laboratory rats that are widely used in scientific research. They were first developed by researchers H.H. Sprague and R.C. Dawley in the early 20th century, and have since become one of the most commonly used rat strains in biomedical research due to their relatively large size, ease of handling, and consistent genetic background.

Sprague-Dawley rats are outbred, which means that they are genetically diverse and do not suffer from the same limitations as inbred strains, which can have reduced fertility and increased susceptibility to certain diseases. They are also characterized by their docile nature and low levels of aggression, making them easier to handle and study than some other rat strains.

These rats are used in a wide variety of research areas, including toxicology, pharmacology, nutrition, cancer, and behavioral studies. Because they are genetically diverse, Sprague-Dawley rats can be used to model a range of human diseases and conditions, making them an important tool in the development of new drugs and therapies.

The human ear consists of three parts-the outer ear, middle ear and inner ear. The ear canal of the outer ear is separated from ... the outer ear, the middle ear and the inner ear. The outer ear consists of the pinna and the ear canal. Since the outer ear is ... During embryogenesis the ear develops as three distinct structures: the inner ear, the middle ear and the outer ear. Each ... The middle ear lies between the outer ear and the inner ear. It consists of an air-filled cavity called the tympanic cavity and ...
A specialty ear splint can also be made to keep the ear compressed, so that the damaged ear is unable to fill thus preventing ... The components of the ear involved in cauliflower ear are the outer skin, the perichondrium, and the cartilage. The outer ear ... Cauliflower ear is an irreversible condition that occurs when the external portion of the ear is hit and develops a blood clot ... Disruption of the ear canal is possible. The outer ear may wrinkle and can become slightly pale due to reduced blood flow; ...
Look up ear candy in Wiktionary, the free dictionary. Ear Candy may refer to: Ear Candy (King's X album), 1996 Ear Candy (Helen ... Reddy album), 1977 This disambiguation page lists articles associated with the title Ear Candy. If an internal link led you ...
The 'clicking your ears' can actually be heard if one puts one's ear to another person's ear for them to hear the clicking ... Ear clearing or clearing the ears or equalization is any of various maneuvers to equalize the pressure in the middle ear with ... This damages hearing, and if this occurs underwater, cold water in the middle ear chills the inner ear, causing vertigo. The ... to engage in an ear clearing method to relieve pressure, or pain if any. The ears can be cleared by various methods, some of ...
Dry cracking skin on the outer ear may also appear causing itchiness. There is no known cause for Ear Eczema. Skin lesion ... Auricular eczema is an eczema of the ear that may involve the helix, postauricular fold, and external auditory canal, with the ... Ear, Eczema, All stub articles, Cutaneous condition stubs). ... Eczema ear infection James WD, Berger T, Elston D (2006). ...
... is the 57th studio album by American vocal group the Temptations. It was released by Motown on May 16, 2000. ... "Ear-Resistable(sic) - The Temptations". Allmusic. Retrieved 18 March 2012. Williams, Otis; Bashe, Patricia Romanowski (2002). ... ISBN 978-0-8154-1218-2. The Temptations - Ear: Resistible Album Reviews, Songs & More , AllMusic, retrieved 2022-07-17 "The ... Ear-Resistible proves that you don't need rap cameos or expletives to make a great R&B album." Terry Weeks - tenor vocals ...
The utricle and saccule are the two otolith organs in the vertebrate inner ear. They are part of the balancing system ( ... Any orientation of the head causes a combination of stimulation to the utricles and saccules of the two ears. The brain ... Wikimedia Commons has media related to Utricle (ear). This article incorporates text in the public domain from page 1051 of the ... Diagram at ipfw.edu THE INNER EAR: THE VESTIBULAR APPARATUS Portal: Anatomy (Articles with short description, Short description ...
... may refer to: Protruding ear, an abnormally protruding human ear A shape of dog ear; see Canine terminology The ear of ... a bat, used for echolocation The ear of a nocturnal insect, primarily used to detect calls from insectivorous bats Bat-eared ... fox This disambiguation page lists articles associated with the title Bat ear. If an internal link led you here, you may wish ...
Severe hypertrichosis of the external ear during minoxidil therapy, where excessive hair covers the ears, may cause ear canal ... In its broader sense, ear hair may also include the fine vellus hair covering much of the ear, particularly at the prominent ... Medical research on the function of ear hair is currently very scarce. Hair growth within the ear canal is often observed to ... "Swimmer's Ear: An Ear Canal Infection" (PDF). Naveh Ltd. Licensed Distributor of Medical Pharmaceuticals. Retrieved March 9, ...
... refers to devices used to protect the ear, either externally from elements such as cold, intrusion by water and ...
Look up wood ear in Wiktionary, the free dictionary. Wood-ear or tree ear (Chinese: 木耳; pinyin: mù'ěr, Korean: 목이 버섯), also ... white/silver ear fungus) The black and cloud ear fungi are black in appearance and closely related. The white ear fungus is ... Auricularia heimuer (黑木耳, black ear fungus), previously misdetermined as Auricularia auricula-judae Auricularia cornea (毛木耳, ... cloud ear fungus), also called Auricularia polytricha Tremella fuciformis (银耳, ...
"Gazzillion Ear" is a single released by British-American hip hop artist DOOM through British independent label Lex Records. It ... "DOOM GAZZILLION EAR (Lex Records)". Lex Records. Archived from the original on 4 February 2010. Retrieved 22 March 2021. The ... Patrin, Nate (7 January 2010). "Gazzillion Ear EP". Pitchfork. Retrieved 9 July 2019. "The Green Whore Net by MF DOOM on ...
... is a good candidate for inclusion in a hearable device, however, due to the high complexity of ear-EEG sensors, this ... The ear-EEG forward models enable prediction of the potentials in the ear for a specific neural phenomenon, and can be used to ... In ear-EEG, the electrodes are exclusively placed in or around the outer ear, resulting in both a much greater invisibility and ... Dry-contact electrode ear-EEG have been used to perform high-density ear-EEG recordings, which enable mapping of the brain ...
... connecting right ear to right ear, or left ear to left ear. The competitors then pull upon the opposing ear using their own ear ... "Torn ears and changed lives at the top of the world". BBC Sport. Retrieved 2023-07-12. Video news report on ear pull ... The Inuit ear pull game is a harsh test of physical endurance....[in which] a thin loop of leather is positioned behind the ... The ear pull is a traditional Inuit game or sport which tests the competitors' ability to endure pain, and also strength. In ...
On October 19, 2021, co-hosts Poor and Woods released a book on the podcast, This Is Ear Hustle. The term "ear hustle" is ... "Webby Winner: Ear Hustle - PRX". Webby Awards. 2018. Retrieved April 7, 2022. "2 Wins: Ear Hustle - PRX". Webby Awards. 2019. ... "About". Ear Hustle. Retrieved 2021-01-20. Larson, Sarah (August 17, 2017). ""Ear Hustle" Listens to Prisoners". The New Yorker ... "Ear Hustle". The Peabody Awards. Retrieved 2022-04-28. "Ear Hustle: Dirty Water". www.thirdcoastfestival.org. Retrieved 2023-01 ...
Cats, as well as dogs with erect ears that have control over ear direction, may be seen with one or both ear pinnas held at an ... Ear mites do not burrow as some mites do, but live within the ear canal. The life cycle of an individual mite is about 4 weeks ... Ear mites are mites that live in the ears of animals and humans. The most commonly seen species in veterinary medicine is ... In pets, ear mites most commonly affect cats, ferrets, and to a lesser extent dogs. Humans can rarely be infected with ear ...
The middle ear is the portion of the ear medial to the eardrum, and distal to the oval window of the cochlea (of the inner ear ... The middle ear efficiency peaks at a frequency of around 1 kHz. The combined transfer function of the outer ear and middle ear ... If middle ear pressure remains low, the eardrum may become retracted into the middle ear.[citation needed] One of the functions ... Damage to the horizontal branch during ear surgery can lead to paralysis of the face (same side of the face as the ear). The ...
Inside an ear of corn is a corncob. In some species (including wheat), unripe ears contribute significantly to photosynthesis, ... A parasite known as Anguina tritici (Ear Cockle) specifically affects the ears on wheat and rye by destroying the tissues and ... "Corn - Ears". Senior Study Vegetables. Purdue University. Retrieved 2012-05-24. "Ear Cockle Disease of Wheat". Agrihunt. ... An ear is the grain-bearing tip part of the stem of a cereal plant, such as wheat or maize (corn). It can also refer to "a ...
Experimental Audio Research (commonly shortened to E.A.R. or EAR) is an experimental music collective formed around Peter ...
Ear mites in animals Ear myiasis, an extremely rare infestation of maggots Foreign body in ear Granuloma, a scar usually caused ... is a pathway running from the outer ear to the middle ear. The adult human ear canal extends from the pinna to the eardrum and ... External and middle ear, opened from the front. Right side. Horizontal section through left ear; upper half of section. Lateral ... waxy substance secreted in the ear canals. It plays an important role in the human ear canal, assisting in cleaning and ...
... is the common name for several species of flowering plants: Hypochaeris species, especially Hypochaeris radicata Some ...
The outer ear, external ear, or auris externa is the external part of the ear, which consists of the auricle (also pinna) and ... Cosmetic defects, such as very large ears, small ears. Malformation that may lead to functional impairment, such as atresia of ... External and middle ear, opened from the front. Right side. This article incorporates text in the public domain from page 1033 ... From the pinna, the sound waves move into the ear canal (also known as the external acoustic meatus) a simple tube running ...
"Ear Mountain". GeoNames. Retrieved 6 May 2013. "Tin Placer And Lode Investigations: Ear Mountain Area, Seward Peninsula, Alaska ... Ear Mountain (Inupiaq: Iŋiġagik) is an isolated mountain located on the Seward Peninsula in the U.S. state of Alaska. The ... In Ear Mountain, a platy structure brought out by the weathering gives the rock a stratified appearance. Rock samples collected ... Located on the Seward Peninsula, the Ear Mountain is 50 miles (80 km) north of Teller, and 10 miles (16 km) southwest from ...
Plastic clip ear tag: a moulded plastic strip, folded over the edge of the ear and joined through it. Metal ear tag: an ... An ear tag is a plastic or metal object used for identification of domestic livestock and other animals. If the ear tag uses ... An ear tag can be applied with an ear tag applicator, however there are also specially-designed tags that can be applied by ... Some cattle ear tags contain chemicals to repel insects, such as buffalo flies, horseflies, etc. Metal ear tags are used to ...
A golden ear is a term used in professional audio circles to refer to a person who is thought to possess special talents in ... A tin ear is an antonym to this talent, someone who is tone-deaf and cannot distinguish what hears well at all. Another meaning ... The term golden ears has also been used by audiologists to describe mature adult test subjects who show a hearing acuity ... A person said to have golden ears is one who can perceive more subtle changes in sound than others, either by training or by ...
A tree ear decomposition is a proper ear decomposition in which the first ear is a single edge and for each subsequent ear P i ... An open ear decomposition or a proper ear decomposition is an ear decomposition in which the two endpoints of each ear after ... ear belong to earlier ears in the sequence and such that the internal vertices of each ear do not belong to any earlier ear. ... A nested ear decomposition is a tree ear decomposition such that, within each ear P j {\displaystyle P_{j}} , the set of pairs ...
... is a hot spring in the Upper Geyser Basin of Yellowstone National Park in the United States. Located close to Old ... Ear Spring in September 2018 showing areas where bacterial mats had been killed (compared to image of 2013) and rocks spouted ... On September 15, 2018, Ear Spring was seen on the National Park Service webcam at Old Faithful erupting for a minute and ... Likely related to the eruption of Ear Spring, a new thermal feature opened up under the pedestrian boardwalk near Pump Geyser ...
... is movement of the external ear using the three muscles which are attached to it forward, above and behind. Some ... Female rats wiggle their ears when they are in heat, to excite male rats and encourage them to mate. Oculo-auricular phenomenon ... Research conducted on humans using a kymograph to measure their ear movements found that only two out of twelve subjects had ... mammals such as cows have good control of these muscles, which they use to twitch and orient their ears, but humans usually ...
An ear trumpet is a tubular or funnel-shaped device which collects sound waves and leads them into the ear. They are used as ... The use of ear trumpets for the partially deaf dates back to the 17th century. The earliest description of an ear trumpet was ... Johann Nepomuk Mälzel began manufacturing ear trumpets in the 1810s. He notably produced ear trumpets for Ludwig van Beethoven ... Collapsible conical ear trumpets were made by instrument makers on a one-off basis for specific clients. Well-known models of ...
"Peachy Keen-O", Ear V, June 1973. Sheff, Robert. "Street", Ear IX, November 1973. Ear Magazine. New Wilderness Foundation. 1977 ... Two Ears existed at this point until the California publication ended in the 1980s. In 1976, Ear began to be published by the " ... Additionally, Ear's printer declared bankruptcy. The final issue was a 1991 Fall Supplement. "archives.nypl.org - Ear magazine ... Over time, Ear began focusing almost exclusively on new music with special attention being paid to Bay Area composers. As it ...
24k gold crystal ear seeds, pellets and vaccaria seeds. Wholesale & PL available! ... Our Ear Seeds kits come complete with ear charts based on auriculotherapy. ... With Over 200 Acupressure Points, The Ear is a Microsystem of the Entire Body. Ear seeds are a non-invasive, safe and effective ... With Over 200 Acupressure Points, The Ear is a Microsystem of the Entire Body. Ear seeds are a non-invasive, safe and effective ...
Health Information on Ear Infections: MedlinePlus Multiple Languages Collection ... Ear Infections: MedlinePlus Health Topic - English Infecciones de los oídos: Tema de salud de MedlinePlus - español (Spanish) ... Middle Ear Infection in Children - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF ... Middle Ear Infection in Children - 繁體中文 (Chinese, Traditional (Cantonese dialect)) Bilingual PDF ...
Swimmers Ear Responsible for Nearly a Half Billion in Health Care Costs ... Dry ears after swimming or showering. *Refrain from putting objects in the ear canal or removing ear wax yourself because both ... Swimmers ear can develop when water stays in the ear canal for a long time, allowing germs to grow and infect the skin. ... Most cases of swimmers ear can be easily treated with prescription antimicrobial ear drops. ...
The inner ear is found in all vertebrates, with substantial variations in form and function. ... the anatomy of the inner ear consists of the bony labyrinth, a system of passages making up the following 2 main functional ... 1, 2] The inner ear is found in all vertebrates, with substantial variations in form and function. The inner ear is innervated ... encoded search term (Inner Ear Anatomy) and Inner Ear Anatomy What to Read Next on Medscape ...
... microphone kit combined with a free phone app has proved to be an effective approach to remotely manage children with glue ear. ... All families chose to keep the kit at the end of the study, even if the childs hearing improved, often fearing glue ear may ... Participants were posted the kit for use at home and school with instructions for the headset and details of the Hear Glue Ear ... Innovative use of bone conduction headphones, a microphone and the Hear Glue Ear app, sent through the post to patients, is a ...
Ear Falls Water Aerodrome (TC LID: CJE8) is located 3 nautical miles (5.6 km; 3.5 mi) south southeast of Ear Falls, Ontario, ... Ear Falls Airport. References[edit]. *^ Nav Canadas Water Aerodrome Supplement. Effective 0901Z 26 March 2020 to 0901Z 22 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Ear_Falls_Water_Aerodrome&oldid=1045470981" ...
Inner ear decompression sickness, (IEDCS) or audiovestibular decompression sickness is a medical condition of the inner ear ... IEDCS and inner ear barotrauma (IEBt) are the inner ear injuries associated with ambient pressure diving, both of which ... Isolated inner ear symptoms, or inner and middle ear on the same sides. Other neurological or dermatological symptoms ... Symptom comparison between inner ear barotrauma and inner ear decompression sickness[19] Barotrauma. Decompression sickness ...
... or cartilage in front of the ear. Theyre painless, but doctors can remove them with surgery. ... An ear tag is a small lump of skin, fat, ... What Is an Ear Tag?. An ear tag is a small lump of skin, fat, ... Doctors can remove ear tags with surgery.. What Are the Signs & Symptoms of an Ear Tag?. An ear tag looks like a small bump or ... What Causes Ear Tags?. An ear tag happens early in pregnancy when the baby is just starting to form. The parts of the ear dont ...
The meaning of DEERS-EAR is any of several tall-growing biennial or short-lived perennial herbs (as American columbo) that ... "Deers-ear." Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/deer%27s-ear. Accessed ...
... the Fender In-Ear Monitor Series is mechanically tuned to deliver music in its purest form-the way you want to hear it. ...
A micro-ear could soon help scientists eavesdrop on tiny events just like microscopes make them visible. ... The micro-ear might mean it is possible to use wild bacteria and many of them to get a much better understanding of what they ... In addition, he said, the team use tiny etched dishes, like a Victorian ear trumpet, to help focus the movements in the fluid ... While many researchers use single beams of laser light to trap single beads, the micro-ear team hopes to use several arranged ...
It is located in the middle ear, just behind the ear drum. Otitis media means inflammation of the middle ear. A puffer attached ... If an infection causes serious complications, fluid remains in the ear for a long time, or your child has ear infections that ... Ear Infections: Diagnosis and Treatment Medically Reviewed by Sabrina Felson, MD on August 04, 2022 ... What Can Cause Ears to Itch Allergies or earwax buildup may be to blame. Learn what to do. ...
TAGS: ear Popular Tags. Florida Friday Photo Fun mug shot roundup assault FBI Florida Man battery South Carolina theft Ohio ... Cops: Ex-Con Bit Off His Boyfriends Ear During Spat At Florida Home. ... Cops: Woman, 19, Bit Off Female Cops Ear Following Brawl Outside Massachusetts Bar. ...
ear 83. earlier 84. earliest 38. early 251. Frequency [« »]. 84 sinai. 83 commandment. 83 cover. 83 ear. 83 endures. 83 formed ... ear. bold = Main text Part, Book Chapter:Verse grey = Comment text. 1 Pent, Exo 9: 31 , because the barley was in ear and the ... Turn your ear to me; when I call, answer 37 WisdB, Psa 116: 2 , 2 ~Who turned an ear to me on the day I called. ~ 38 WisdB, Pro ... Turn your ear to me; hear my prayer. ~ 32 WisdB, Psa 31: 3 , 3 ~incline your ear to me; make haste to rescue 33 WisdB, Psa 49: ...
Swimmers ear (otitis externa) is a redness or swelling (inflammation), irritation, or infection of your outer ear canal. ... Taking ear drops to kill bacteria (antibiotic ear drops). *Taking ear drops to help reduce swelling (corticosteroid ear drops) ... Head and Neck Ear Nose and Throat Pediatric ENT (Otolaryngology) What is swimmers ear?. Swimmers ear (otitis externa) is a ... The ear canal is a tube that goes from the opening of the ear to the eardrum. When water stays in your ear canal, germs can ...
The human ear consists of three parts-the outer ear, middle ear and inner ear. The ear canal of the outer ear is separated from ... the outer ear, the middle ear and the inner ear. The outer ear consists of the pinna and the ear canal. Since the outer ear is ... During embryogenesis the ear develops as three distinct structures: the inner ear, the middle ear and the outer ear. Each ... The middle ear lies between the outer ear and the inner ear. It consists of an air-filled cavity called the tympanic cavity and ...
... a new in-ear bioelectronic called SpiralE may be the next step toward seamless brain-computer interfaces. ... Body parts in details - Closeup view of black female ear. getty. This story is part of a series on the current progression in ... In a recent study in Nature, the researchers describe a new in-ear bioelectronic they call SpiralE. In place of a bulky ... FIGURE 1: Pictures of SpiralE conformally adapting to the inner wall of the ear canal. Upper-right ... [+] inset is a ...
Learn more about ear infection questions including symptoms of ear infections and cause of ear infections, as well as when to ... Ear Tube Surgery Questions. *Ear Tubes: *Ear tubes are tiny plastic tubes that are put through the eardrum. They are placed by ... Ear Tubes - When Are They Needed?*Fluid has been present in the middle ear nonstop for over 4 months. Both ears have fluid. ... How often do kids get ear infections? 90% of children have at least 1 ear infection. Frequent ear infections occur in 20% of ...
Surgery begins with an incision just behind the ear in the natural fold where the ear is joined to the head. The surgeon will ... the surgeon will apply sutures to anchor the ear until healing occurs to hold the ear in the desired position. ... My ears always stuck out, one more than the other. Growing up, I was very self-conscious. I never wore my hair in a pony tail. ... Even if the ears are only mildly distorted, the condition can lead to self-consciousness and poor adaptation to school. It is ...
The meaning of EAR CLIP is an earring with a clip fastener. ... Examples of ear clip in a Sentence. Recent Examples on the Web ... The Jaybird Vista is our runner-up, despite lacking a behind-the-ear wire or over-ear clip for security. -. Wired Staff, Wired ... 2019 The over-ear clip makes them stable and comfortable, and the W1 chip makes pairing a breeze. -. Adrienne So, WIRED, 11 ... 2020 The guests giddied into the night no doubt writing fantasy Christmas lists: a playful pair of ear clips made of amethyst, ...
People can usually manage their symptoms by using ear drops or creams and avoiding potential triggers. ... Eczema can affect the ear externally or internally. ... In ear eczema, the skin on the ear can become discolored, dry, ... The ear canal connects the outer cartilage of the ear to the eardrum, which allows people to hear. Read on to learn more about ... Ear eczema causes symptoms similar to those of eczema on other parts of the body. People with ear eczema may experience: ...
Chronic ear infections are more common in children. In this article, we look at the types, causes, and treatments for chronic ... or recurring ear infections require medical attention. They are caused by a build-up of fluid behind the eardrum that persists ... of ear infections that affect the middle ear:. *Acute otitis media (AOM) is the most common type of ear infection. Fluid builds ... Chronic ear infections develop from a long-lasting or recurrent acute ear infection. Preventing acute ear infections can help ...
We conclude that ear malformations are associated with an increased frequency of clinically significant structural renal ... A renal ultrasound should be performed in patients with isolated preauricular pits, cup ears, or any other ear anomaly ... Syndromic ear anomalies and renal ultrasounds Pediatrics. 2001 Aug;108(2):E32. doi: 10.1542/peds.108.2.e32. ... We defined a child as having an external ear anomaly when he or she had any of the following: preauricular pits and tags; ...
A specialty ear splint can also be made to keep the ear compressed, so that the damaged ear is unable to fill thus preventing ... The components of the ear involved in cauliflower ear are the outer skin, the perichondrium, and the cartilage. The outer ear ... Cauliflower ear is an irreversible condition that occurs when the external portion of the ear is hit and develops a blood clot ... Disruption of the ear canal is possible. The outer ear may wrinkle and can become slightly pale due to reduced blood flow; ...
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Scientists Create First Nano-Ear to Listen in on Sounds of Cells. By Michael Ricciardi ...
Childrens pediatric plastic surgeons and otolaryngologists have years of experience repairing and reshaping all types of ear ... Neonatal Ear Molding. Description Minor ear deformities such as cup ear or lop ear may be reshaped with custom ear molds. A ... About Ear Deformities. We treat a variety of ear deformities that affect the ears structure, appearance, and/or function ... Prosthetic Ear Replacement. Description A deformed or missing ear may also be replaced by a prosthetic ear made of medical- ...
Dries moisture in the ear canal, and will not irritate or burn the ear. Ready to use formula. ... Dries moisture in the ear canal, and will not irritate or burn the ear. Ready to use formula. ... and provide instant relief to the ear canal. When used regularly cleaner also reduces ear odors. Contains natural eucalyptus ... Stazko Ear Cleaner soothes, cleans & deodorizes! Specially formulated to clean, reduce inflammation, ...
  • With fluid in the middle ear, the eardrum is more rigid and doesn't move back and forth. (webmd.com)
  • The ear canal of the outer ear is separated from the air-filled tympanic cavity of the middle ear by the eardrum. (wikipedia.org)
  • The outer ear is the external portion of the ear and includes the fleshy visible pinna (also called the auricle), the ear canal, and the outer layer of the eardrum (also called the tympanic membrane). (wikipedia.org)
  • The ear canal ends at the external surface of the eardrum. (wikipedia.org)
  • The ossicles are three small bones that function together to receive, amplify, and transmit the sound from the eardrum to the inner ear. (wikipedia.org)
  • The opening to the middle ear (the area behind the eardrum) lets air flow in and out. (kidshealth.org)
  • This keeps air pressure even between the middle ear and the outside, and helps to drain fluid that builds up behind the eardrum. (kidshealth.org)
  • Ear tubes usually fall out on their own, pushed out as the eardrum heals. (kidshealth.org)
  • The surgeon will make a small hole in each eardrum and remove fluid from the middle ear using suction. (kidshealth.org)
  • Because the surgeon can reach the eardrum through the ear canal, there are no visible cuts or stitches. (kidshealth.org)
  • The ear canal is a tube that goes from the opening of the ear to the eardrum. (hopkinsmedicine.org)
  • But swimmer's ear happens when bacteria grow in the ear canal, which is a passageway to the eardrum . (kidshealth.org)
  • The middle ear is a small space behind your eardrum. (webmd.com)
  • If a doctor looks at your child's eardrum and sees that it's red and bulging, they'll diagnose them with an ear infection. (webmd.com)
  • Swimmer's ear can develop when water stays in the ear canal for a long time, allowing germs to grow and infect the skin. (cdc.gov)
  • The outer ear consists of the pinna and the ear canal. (wikipedia.org)
  • The pinna consists of the curving outer rim called the helix, the inner curved rim called the antihelix, and opens into the ear canal. (wikipedia.org)
  • The tragus protrudes and partially obscures the ear canal, as does the facing antitragus. (wikipedia.org)
  • The hollow region in front of the ear canal is called the concha. (wikipedia.org)
  • The ear canal stretches for about 1 inch (2.5 cm). (wikipedia.org)
  • The skin surrounding the ear canal contains ceruminous and sebaceous glands that produce protective ear wax. (wikipedia.org)
  • Eczema can appear anywhere on the body, including the outside of the ear or inside the ear canal. (medicalnewstoday.com)
  • Swimmer's ear (otitis externa) is a redness or swelling (inflammation), irritation, or infection of your outer ear canal. (hopkinsmedicine.org)
  • When water stays in your ear canal, germs can grow. (hopkinsmedicine.org)
  • A cotton swab is placed gently in your ear canal to get a sample. (hopkinsmedicine.org)
  • Hearing loss from a swollen and inflamed ear canal. (hopkinsmedicine.org)
  • Don't scratch or clean your ear canal with cotton swabs, your fingers, or other objects. (hopkinsmedicine.org)
  • It is a redness or swelling (inflammation), irritation, or infection of the outer ear canal. (hopkinsmedicine.org)
  • The layers include electrothermal components, wiring, adhesion, and so on, all packed together in a memory polymer that molds to the ear canal of the user, maximizing comfort and stability. (forbes.com)
  • FIGURE 1: Pictures of SpiralE conformally adapting to the inner wall of the ear canal. (forbes.com)
  • The spiral design allows for an unobstructed ear canal, and auditory tests run by Dr. Wang and colleagues confirm that not only does the user continue to hear unobstructed at cocktail party noise levels, but the device itself continues to function with 84% accuracy in high volume environments. (forbes.com)
  • Swimmer's ear is an infection of the ear canal . (kidshealth.org)
  • If you stick your finger in your ear, you're feeling a little of the ear canal. (kidshealth.org)
  • Most of the time, water can run in and out of the ear canal without causing a problem. (kidshealth.org)
  • Bacteria get a chance to grow when water stays in the ear canal. (kidshealth.org)
  • Bacteria grow and the ear canal gets red and swollen. (kidshealth.org)
  • Sometimes kids can get an infection in the ear canal even if they haven't been swimming. (kidshealth.org)
  • A scratch or other irritation to the ear canal can also lead to swimmer's ear. (kidshealth.org)
  • The infection also could make it harder to hear with the infected ear because of the swelling that happens in the ear canal. (kidshealth.org)
  • The medicine goes into the sponge and it keeps the medicine touching the ear canal that's infected. (kidshealth.org)
  • The external ear canal may be atretic (absent). (cdc.gov)
  • The spectrum of severity in microtia ranges from a measurably small external ear (defined as longitudinal ear length below minus two SD from the mean, or approximately 3.3 cm in the term newborn) with minimal structural abnormality, to an ear that consists of few rudimentary structures and an absent or blind-ending external ear canal. (cdc.gov)
  • Severity - I-IV degree, based on the extent of external ear involvement and atresia of the external canal. (cdc.gov)
  • For the purpose of local anesthesia, this article focuses on the external ear which comprises the auricle, or pinna, and the ear canal. (medscape.com)
  • The ring block, shown in the image below, provides anesthesia to the entire ear, excluding the concha and external auditory canal. (medscape.com)
  • 10 count What the Ear Process does: Our bodies produce earwax cerumen near the entrance to the ear canal in order to protect the inner ear from dust, debris and particulate. (shoprite.com)
  • This wax is then migrated out of the ear canal by a body process. (shoprite.com)
  • That's because they don't fight off viruses and bacteria as well, and their little ears aren't good at draining fluids yet. (webmd.com)
  • Bacteria or viruses can enter the middle ear and fill it with fluid or pus. (kidshealth.org)
  • The micro-ear might mean it is possible to use wild bacteria and many of them to get a much better understanding of what they do. (bbc.co.uk)
  • Wired Staff, Wired , 31 Oct. 2020 But really, dirty glasses can also negatively impact your health: Bacteria can grow on nose pads and ear clips of eyeglasses, leading to staph infections and other skin issues, according to a 2018 study. (merriam-webster.com)
  • The antibiotic will kill the bacteria that are causing the ear infection. (seattlechildrens.org)
  • To do that, the doctor will probably prescribe ear drops that contain an antibiotic to kill the bacteria. (kidshealth.org)
  • Viruses cause most ear infections, although sometimes bacteria are the culprit. (medicalnewstoday.com)
  • Busy day-care centers can also increase the risk of children developing ear infections, as they come into more contact with viruses and bacteria. (medicalnewstoday.com)
  • Bacteria can cause an ear infection, but usually these germs come after a virus or an allergic reaction . (webmd.com)
  • Bacteria can infect an already inflamed ear and cause other symptoms, like a fever . (webmd.com)
  • A shot called the conjugate pneumococcal vaccine can help protect your child against some of the most common bacteria that cause ear infections. (webmd.com)
  • Swimmer's ear leads to about 2.4 million doctor visits each year and is responsible for nearly $500 million dollars in annual health care costs, according to estimates released by CDC on Thursday. (cdc.gov)
  • Exposure to water-through swimming, bathing and other activities-and living in warm and humid climates increase the risk of developing swimmer's ear. (cdc.gov)
  • Germs found in pools and at other recreational water venues are one of the most common causes of swimmer's ear. (cdc.gov)
  • Most cases of swimmer's ear can be easily treated with prescription antimicrobial ear drops. (cdc.gov)
  • In 2007, 1 in 123 Americans went to the doctor for swimmer's ear. (cdc.gov)
  • Between 2003 and 2007, rates of doctor's visits for swimmer's ear were highest in children between the ages of 5 and 14 years. (cdc.gov)
  • People living in the South had the highest regional rate of swimmer's ear. (cdc.gov)
  • To estimate the costs associated with swimmer's ear, CDC scientists used a large proprietary database that contains health care claims for millions of people who have employer-provided health insurance, the Marketscan commercial claims database. (cdc.gov)
  • They identified outpatient cases of swimmer's ear and analyzed the total cost for each visit. (cdc.gov)
  • That average cost was multiplied by the 2.4 million cases to determine the overall cost estimate for swimmer's ear cases. (cdc.gov)
  • Most people think of swimmer's ear as a mild condition that quickly goes away, but this common infection is responsible for millions of illnesses and substantial medical costs each year," said Michael Beach, Ph.D., CDC's associate director for healthy water. (cdc.gov)
  • What is swimmer's ear? (hopkinsmedicine.org)
  • Swimming in unclean water is a common cause of swimmer's ear. (hopkinsmedicine.org)
  • Who is at risk for swimmer's ear? (hopkinsmedicine.org)
  • What are the symptoms of swimmer's ear? (hopkinsmedicine.org)
  • The symptoms of swimmer's ear may look like other health problems. (hopkinsmedicine.org)
  • How is swimmer's ear diagnosed? (hopkinsmedicine.org)
  • How is swimmer's ear treated? (hopkinsmedicine.org)
  • With proper treatment from a healthcare provider, swimmer's ear often clears up in 7 to 10 days. (hopkinsmedicine.org)
  • What are the complications of swimmer's ear? (hopkinsmedicine.org)
  • What can I do to prevent swimmer's ear? (hopkinsmedicine.org)
  • But if you have swimmer's ear, and you stick your finger in your ear - YOW! (kidshealth.org)
  • How Does Swimmer's Ear Happen? (kidshealth.org)
  • Swimmer's ear - also called otitis externa (say: o-TY - tus ek-STUR-nuh) - is different from a regular ear infection. (kidshealth.org)
  • For instance, you don't usually get swimmer's ear from taking baths or showers. (kidshealth.org)
  • How Do I Know if I Have Swimmer's Ear? (kidshealth.org)
  • Swimmer's ear may start with some itching, but try not to scratch because this can make the infection worse. (kidshealth.org)
  • Ear pain is the most common sign of swimmer's ear. (kidshealth.org)
  • If a doctor thinks you have swimmer's ear, they will help you get rid of the infection. (kidshealth.org)
  • If you have a big problem with swimmer's ear or you're a kid who's always in the water, the doctor may suggest ways for you to protect yourself. (kidshealth.org)
  • Rushinga, Zimbabwe - To build the capacity of health care professionals to provide essential ear and hearing care services to communities, the Ministry of Health and Child Care conducted a four-day training from 25 -27 October 2023 in Rushinga District, Mashonaland Central Province. (who.int)
  • You can place a clean cotton ball in the opening of each ear to catch the drainage, but don't stick cotton swabs in the ears. (kidshealth.org)
  • The use of cotton swabs as an ear cleaner can smear wax and debris back into the ear. (shoprite.com)
  • All families chose to keep the kit at the end of the study, even if the child's hearing improved, often fearing glue ear may return. (medscape.com)
  • If your child's doctor prescribed pain medicine and/or ear drops to use after the surgery, give them as directed. (kidshealth.org)
  • A soft silicone mold is created to hold your child's ear in a better, more normal shape. (dukehealth.org)
  • Autologous refers to the use of your child's own cartilage to reconstruct the missing or severely deformed ear. (dukehealth.org)
  • Cartilage is taken from your child's ribs, then carved and shaped into the framework for a new ear. (dukehealth.org)
  • A t times, fluid can also build up in your child's middle ear without signs of infection. (webmd.com)
  • Often, a virus causes an ear infection, in which case antibiotics won't help. (webmd.com)
  • If an infection causes serious complications, fluid remains in the ear for a long time, or your child has ear infections that keep coming back, your doctor might want to do a procedure called a myringotomy . (webmd.com)
  • The ear may be affected by disease, including infection and traumatic damage. (wikipedia.org)
  • This will help to see if you also have an infection in your middle ear. (hopkinsmedicine.org)
  • The sample is sent to a lab to find out what is causing the ear infection. (hopkinsmedicine.org)
  • of children with an ear infection will have a fever. (seattlechildrens.org)
  • 90% of children have at least 1 ear infection. (seattlechildrens.org)
  • Ear infections are the most common bacterial infection of young children. (seattlechildrens.org)
  • Reason: To stop the ear infection from flaring up again. (seattlechildrens.org)
  • Let's find out more about this painful type of ear infection, which often affects swimmers. (kidshealth.org)
  • Usually, when people say a kid has an ear infection, they mean otitis media (say: ME-dee-uh), an infection of the middle ear. (kidshealth.org)
  • Sometimes, an ear infection can come back again and again. (medicalnewstoday.com)
  • We also discuss the ways to treat and prevent a chronic ear infection. (medicalnewstoday.com)
  • Acute otitis media (AOM) is the most common type of ear infection. (medicalnewstoday.com)
  • It develops after an original ear infection has resolved, but fluid remains trapped in the middle ear. (medicalnewstoday.com)
  • Another form of chronic ear infection is called chronic suppurative otitis media (CSOM). (medicalnewstoday.com)
  • A person's symptoms will differ depending on the type of ear infection they have. (medicalnewstoday.com)
  • Someone with a chronic ear infection does not usually have any visible symptoms. (medicalnewstoday.com)
  • Chronic ear infections develop from a long-lasting or recurrent acute ear infection. (medicalnewstoday.com)
  • Preventing acute ear infections can help prevent chronic ear infection. (medicalnewstoday.com)
  • Anyone who still has an ear infection after several days should seek medical attention to find out the type of ear infection they have. (medicalnewstoday.com)
  • About half of kids get at least one ear infection, also known as acute otitis media , before their second birthday. (webmd.com)
  • What Causes an Ear Infection? (webmd.com)
  • The most common trigger of an ear infection in kids is an upper respiratory infection , like a cold or the flu . (webmd.com)
  • Some kids only get an ear infection once, or once in awhile. (webmd.com)
  • If so, it's called acute ear infection (or acute otitis media) . (webmd.com)
  • About half the time, an ear infection goes away on its own. (webmd.com)
  • Is there anything that's worse than having a child who might be suffering from an ear infection? (popsci.com)
  • While the Oto Home can't itself tell you whether or not someone is suffering from an ear infection, its companion app lets you take a video of the ear and send it to a medical professional, who can then hopefully diagnose the condition-and potentially even prescribe treatment. (popsci.com)
  • Vogue , 18 Oct. 2019 The over- ear clip makes them stable and comfortable, and the W1 chip makes pairing a breeze. (merriam-webster.com)
  • In mammals, the anatomy of the inner ear consists of the bony labyrinth, a system of passages making up the following 2 main functional parts: (1) the cochlea, which is dedicated to hearing, and (2) the vestibular system, which is dedicated to balance. (medscape.com)
  • The inner ear is innervated by the eighth cranial nerve in all vertebrates. (medscape.com)
  • Inner ear, coronal section. (medscape.com)
  • The superficial contours of the inner ear are established by a layer of dense bone known as the bony labyrinth, which refers to the network of canals. (medscape.com)
  • During week 4 of embryonic development, the human inner ear develops from the auditory placode, a thickening of the ectoderm that gives rise to the bipolar neurons of the cochlear and vestibular ganglions. (medscape.com)
  • Inner ear decompression sickness , (IEDCS) or audiovestibular decompression sickness is a medical condition of the inner ear caused by the formation of gas bubbles in the tissues or blood vessels of the inner ear. (wikipedia.org)
  • In mammals the ear is usually described as having three parts: the outer ear, the middle ear and the inner ear. (wikipedia.org)
  • The human ear consists of three parts-the outer ear, middle ear and inner ear. (wikipedia.org)
  • The inner ear contains the otolith organs-the utricle and saccule-and the semicircular canals belonging to the vestibular system, as well as the cochlea of the auditory system. (wikipedia.org)
  • The middle ear lies between the outer ear and the inner ear. (wikipedia.org)
  • The three ossicles transmit sound from the outer ear to the inner ear. (wikipedia.org)
  • However, abnormalities of the middle and inner ear, commonly associated with the more severe degrees of microtia, should be sought, and typically require advanced imaging (CT or MRI scan), surgery, or autopsy. (cdc.gov)
  • The ear is composed of 3 compartments: the external ear, the middle ear, and the inner ear. (medscape.com)
  • Only Lipo-Flavonoid contains the exclusive Tisina complex, a proprietary blend of high potency ingredients, clinically shown to be important to functionality of the inner ear. (shoprite.com)
  • If skin irritation occurs from the ear seeds, or if swelling should occur, remove the ear seeds and contact your doctor if symptoms persist. (earseeds.com)
  • This article will discuss the possible causes, symptoms, diagnosis, and treatment of ear eczema. (medicalnewstoday.com)
  • Ear eczema causes symptoms similar to those of eczema on other parts of the body. (medicalnewstoday.com)
  • The symptoms of ear eczema can also affect the area behind the ear. (medicalnewstoday.com)
  • Mastoiditis, which is an uncommon condition that causes AOM symptoms as well as redness or swelling behind the ear. (medicalnewstoday.com)
  • The symptoms may be present in one or both ears and may come and go. (medicalnewstoday.com)
  • Fluid build-up in the middle ear can become infected, which will cause pain and other symptoms. (medicalnewstoday.com)
  • Innovative use of bone conduction headphones, a microphone and the Hear Glue Ear app, sent through the post to patients, is a novel, new and effective approach to the management of glue ear and its resulting hearing loss, especially when families have reduced access to audiology or Ear Nose and Throat (ENT) services, such as during the COVID-19 pandemic,' the authors write. (medscape.com)
  • The middle ear contains the three small bones-the ossicles-involved in the transmission of sound, and is connected to the throat at the nasopharynx, via the pharyngeal opening of the Eustachian tube. (wikipedia.org)
  • The middle ear also connects to the upper throat at the nasopharynx via the pharyngeal opening of the Eustachian tube. (wikipedia.org)
  • An ear, nose, and throat (ENT) surgeon will do the surgery, called a myringotomy (meer-in-GOT-uh-mee). (kidshealth.org)
  • The eustachian tube joins the middle ear to the back of the throat. (seattlechildrens.org)
  • Acute ear infections happen when the eustachian tube, a tube that runs from the middle ear to the back of the throat, becomes clogged. (medicalnewstoday.com)
  • This part of your ear is supposed to be vented by air that passes into your nose and throat and through a passage called the eustachian tube. (webmd.com)
  • An ear nose and throat specialist provided hands-on demonstrations of ear examinations using autoscopes and ear washout techniques. (who.int)
  • A bone conduction (BC) headset and microphone kit combined with a free phone app has proved to be an effective approach to remotely manage children with glue ear (otitis media with effusion [OME]), the results of a new study suggest. (medscape.com)
  • Chronic otitis media with effusion (COME) is when fluid stays in the ear for an extended period or keeps coming back. (medicalnewstoday.com)
  • Apple has discretely updated its premium In-Ear Headphones, replacing the rubber 3.5 mm headphone plug casing with a hard plastic one, perhaps in an attempt to fix cord protectors that users complained came easily unfastened. (appleinsider.com)
  • Appleâ s In-Ear Headphones replaced the original, $39 upgrade model, which were largely considered to be a flop. (appleinsider.com)
  • And after the debut of the iPhone, the second-generation iPod touch, and fourth-generation iPod nano, the ability to record voice became a crucial component of any headphone upgrade, so the improved In-Ear Headphones filled that need. (appleinsider.com)
  • The premium upgrade features three different sizes of ear tips and a carrying case for the tips and headphones. (appleinsider.com)
  • Your provider will give you instructions on how to use ear drops. (hopkinsmedicine.org)
  • Your health care provider may recommend drops to help dry your ears. (hopkinsmedicine.org)
  • Use the drops as long as your doctor tells you to, even if your ear starts feeling better. (kidshealth.org)
  • For instance, your mom or dad can get some special drops to put in your ears after swimming to dry up the water in there. (kidshealth.org)
  • Add Auro DRI Ear Drying Drops, 1 fl oz to Favorites. (shoprite.com)
  • Add Similasan Earache Relief Ear Drops, 0.33 fl oz to Favorites. (shoprite.com)
  • Microtia/anotia is a congenital malformation of the ear in which the external ear (auricle) is underdeveloped and either abnormally shaped (microtia) or absent (anotia). (cdc.gov)
  • Birth defects in which a child is born with a partial ear (microtia) or complete absence of an ear (anotia). (dukehealth.org)
  • More complex treatment is required for small, deformed ears (microtia) and missing ears (anotia). (dukehealth.org)
  • Cauliflower ear can also present in the setting of nontraumatic inflammatory injury of auricular connective tissue such as in relapsing polychondritis (RP), a rare rheumatologic disorder in which recurrent episodes of inflammation result in destruction of cartilage of the ears and nose. (wikipedia.org)
  • The components of the ear involved in cauliflower ear are the outer skin, the perichondrium, and the cartilage. (wikipedia.org)
  • After sculpting the cartilage to the desired shape, the surgeon will apply sutures to anchor the ear until healing occurs to hold the ear in the desired position. (aafprs.org)
  • These are often called "cauliflower ears" and result from a buildup of blood, scar tissue, or cartilage. (dukehealth.org)
  • Your baby's ear cartilage will gently remodel over the next several months. (dukehealth.org)
  • Some children are born with extra tags of skin and cartilage attached to their ear or on their cheek in front of the ear. (dukehealth.org)
  • The auricle (visible part of ear) is composed mainly of cartilage covered by skin and consists of the helix, antihelix, lobule, tragus, and concha. (medscape.com)
  • This is called an ear drainage culture. (hopkinsmedicine.org)
  • Swimming is fine as long as there is no drainage from the ear. (seattlechildrens.org)
  • Anesthesia of the ear is useful for repair of lacerations, hematoma incision and drainage, and other painful procedures of the ear. (medscape.com)
  • Allergies, post-nasal drainage, sinus infections, common cold viruses, and problems with the tonsils can all prevent enough air from passing into the middle ear. (webmd.com)
  • People should consult with their health care provider if their ears are itchy, flaky, swollen or painful or have fluid draining from them. (cdc.gov)
  • As a result, the outer ear becomes permanently swollen and deformed, resembling a cauliflower, hence the name. (wikipedia.org)
  • It is located in the middle ear, just behind the ear drum. (webmd.com)
  • If anything blocks air from getting through, the middle ear can become damp and warm - a perfect breeding ground for germs. (webmd.com)
  • It's called a tympanometer, and it uses sound and air pressure to check for fluid in the middle ear. (webmd.com)
  • The tube, which will usually fall out on its own in about 6 to 18 months, lets the fluid out and air flow through to keep the middle ear dry. (webmd.com)
  • Ear tube surgery can drain fluid from the middle ear, prevent future infections, and help the child hear properly again. (kidshealth.org)
  • You might see a small amount of fluid draining from the ears for a couple of days. (kidshealth.org)
  • As such, said Professor Padgett, the wobble can be measured and used to turn the wobbles in the fluid surrounding the subject into sound giving an ear to events on the tiniest of scales. (bbc.co.uk)
  • In addition, he said, the team use tiny etched dishes, like a Victorian ear trumpet, to help focus the movements in the fluid surrounding an object and make them easier to pick up. (bbc.co.uk)
  • Cauliflower ear is an irreversible condition that occurs when the external portion of the ear is hit and develops a blood clot or other collection of fluid under the perichondrium. (wikipedia.org)
  • The ear then drains cloudy fluid or pus. (seattlechildrens.org)
  • Blockage results in middle ear fluid (called viral otitis). (seattlechildrens.org)
  • The ER-9, ER-15, or ER-25 filters are embedded in custom ear molds for a natural sound plug with a perfect fit, and because the filters are interchangeable, you can choose from three different levels of sound reduction to get just the sound reduction you need to listen comfortably while still maintaining your peak performance. (askjan.org)
  • Minor ear deformities such as cup ear or lop ear may be reshaped with custom ear molds. (dukehealth.org)
  • The ear is a self cleaning organ through its relationship with earwax and the ear canals. (wikipedia.org)
  • A simple push-in motion is all it takes to get these ear plugs seated properly in your ear canals. (askjan.org)
  • With NRR 15 noise protection, these foam ear plugs for musicians will help prevent hearing damage and tinnitus with minimal distortion of sound. (askjan.org)
  • Sound protection foam ear plugs can push wax back into the ear. (shoprite.com)
  • The most common cause of cauliflower ear is blunt trauma to the ear leading to a hematoma which, if left untreated, eventually heals to give the distinct appearance of cauliflower ear. (wikipedia.org)
  • Perichondral hematoma and consequently cauliflower ear are diagnosed clinically. (wikipedia.org)
  • To assist with settling on the best form of treatment for cauliflower ear Yotsuyanagi et al. (wikipedia.org)
  • A specialty ear splint can also be made to keep the ear compressed, so that the damaged ear is unable to fill thus preventing cauliflower ear. (wikipedia.org)
  • These viruses can swell the eustachian tube so that air can't flow into the middle ear. (webmd.com)
  • Otitis media means inflammation of the middle ear . (webmd.com)
  • In this article, we look at the different types of ear infections and what makes them chronic. (medicalnewstoday.com)
  • When younger children get these ear tubes, it's surgery. (webmd.com)
  • Ear tubes are tiny tubes made of metal or plastic. (kidshealth.org)
  • During ear tube surgery, a small hole is made in the eardrums and the tubes are inserted. (kidshealth.org)
  • Ear tubes are also called tympanostomy tubes, myringotomy tubes, ventilation tubes, or pressure equalization (PE) tubes. (kidshealth.org)
  • Ear tubes help prevent ear infections by allowing air into the middle ear. (kidshealth.org)
  • It's OK for your child to travel in airplanes after having ear tubes placed. (kidshealth.org)
  • The ear tubes will help even out air pressure inside and outside the ear. (kidshealth.org)
  • Ear tubes won't prevent all ear infections, but they can make them milder and happen less often. (kidshealth.org)
  • Children are more likely to be affected by ear infections because these tubes are shorter and narrower, so they become clogged more easily. (medicalnewstoday.com)
  • For many years, kids who had repeat ear infections and hearing loss were given "ear tubes. (webmd.com)
  • During a short surgery called a myringotomy, tiny tubes are put into the ear to keep the middle ear vented. (webmd.com)
  • Studies show that ear tubes aren't always needed. (webmd.com)
  • If your doctor suggests ear tubes for your child, you might want a second opinion. (webmd.com)
  • Long before ear tubes are discussed, many doctors prescribe antibiotics . (webmd.com)
  • Exclude microtia type I - small ear with normal components or with minor anomalies of individual structures is a minor anomaly, not to be included in public health surveillance. (cdc.gov)
  • The ear develops from the first pharyngeal pouch and six small swellings that develop in the early embryo called otic placodes, which are derived from ectoderm. (wikipedia.org)
  • A tube generally stays in the ear anywhere from 6 months to 18 months, depending on the type of tube used. (kidshealth.org)
  • Though the shape of the ear itself is indiscernible to visitors, disappearing at ground level and blending naturally with its surroundings, Kozak-iewicz believes that we find comfort in spaces that reflect our own contours, echoing the Vitruvian ideal of the human body as the measure for architecture. (metropolismag.com)
  • Delineating the position and shape of the ear might require threedimensional ultrasound. (cdc.gov)
  • People with untreated or chronic ear infections can develop several complications. (medicalnewstoday.com)
  • It's an extra step that just might keep your ears in super shape all summer! (kidshealth.org)
  • People should speak with their doctor when they first notice ear eczema for proper diagnosis and treatment. (medicalnewstoday.com)
  • On the ears, it can commonly occur due to contact with earrings or cosmetics people use on the surrounding hair. (medicalnewstoday.com)
  • CDC, public health and regulatory officials in several states, and the FDA external icon investigated a multistate outbreak of Salmonella Stanley infections linked to wood ear mushrooms (also commonly known as kikurage or dried fungus). (cdc.gov)
  • Wood ear mushrooms are also commonly referred to as kikurage, dried black fungus, dried fungus, or mu'er/mu er/mu-err. (cdc.gov)
  • Use ear plugs when you are swimming or showering. (hopkinsmedicine.org)
  • With these ear plugs in, you'll still be able to hear what's going on around you, including detailed music and voices. (askjan.org)
  • What makes Comply™ Foam Plugs different is that these are foam-tipped musician's ear plugs. (askjan.org)
  • Most ear plugs for music are made of silicone and have a multi-flange fitting system. (askjan.org)
  • Perfect-Fit™ CMP Model Custom Musician Ear Plugs, featuring acoustic filters from Etymotic Research are one of the finest hearing protection products currently available for the professional musician or for anyone needing to be able to hear clearly but at a reduced volume. (askjan.org)
  • These custom molded musician ear plugs require you to mail us impressions of your ears. (askjan.org)
  • Now you can make your own impressions right at home using our do-it-yourself impression kit or visit a local audiologist to get your impressions made, then get your perfectly fitted custom musicians ear plugs shipped to your door. (askjan.org)
  • Custom musicians ear plugs are not just for musicians. (askjan.org)
  • Thunderplugs ear plugs are designed for music festivals and concerts, by serious music lovers who know all-too-well what can happen without proper protection from hazardously loud noise. (askjan.org)
  • Westone Style ES49 custom musicians ear plugs have been the first choice of performing musicians around the world for decades. (askjan.org)
  • Add Hearos Xtreme Protection NRR 33 Ear Plugs, 14 pair to Favorites. (shoprite.com)
  • The ears of vertebrates are placed somewhat symmetrically on either side of the head, an arrangement that aids sound localization. (wikipedia.org)
  • Many kids get middle ear infections (otitis media) . (kidshealth.org)
  • The following can put your child at risk for repeat middle ear infections. (webmd.com)
  • Ear eczema can be a chronic condition, but treatments are available that can manage the condition well. (medicalnewstoday.com)
  • These are called chronic or recurring ear infections. (medicalnewstoday.com)
  • AFRO subsequently developed two ear and hearing care modules tailored for PHC: chronic suppurative otitis media and screening for hearing loss in children for early intervention. (who.int)
  • The training equipped participants with the knowledge and skills to assess, diagnose, and treat patients presenting with chronic suppurative otitis media and hearing loss, the two most prevalent ear conditions in Africa. (who.int)
  • I was so excited about this ear trainer that I have developed an Android app based on the Alain Benbassat method. (google.com)
  • The Android(TM) mobile phone application ear allows users to create environment-aware settings profiles. (slideme.org)
  • Your provider may check your ears using a lighted tool (otoscope). (hopkinsmedicine.org)
  • in this case, it's an otoscope-the black conical doohickey that doctors use to look at your ear. (popsci.com)
  • There's also a $299 professional version aimed at clinicians that enables the device to be used as a pneumatic otoscope , which lets doctors judge how the ear responds to changes in pressure. (popsci.com)
  • Importantly, an auricular hematoma can also occur on the posterior ear surface, or even both surfaces. (wikipedia.org)
  • Frequent ear infections occur in 20% of children. (seattlechildrens.org)
  • Diseases of the ear may lead to hearing loss, tinnitus and balance disorders such as vertigo, although many of these conditions may also be affected by damage to the brain or neural pathways leading from the ear. (wikipedia.org)
  • Objective: The aim of this non-randomized, mixed-methods observational study was to describe the utilization rate and nurses' experiences of ear acupuncture in a highly specialized clinic for eating disorders in Sweden, in which acupuncture had been implemented as part of routine clinical care. (lu.se)