A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.
Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.
The period of history from 1601 of the common era to the present.
An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM.
I'm sorry for any confusion, but "Iraq" is a country located in the Middle East and it doesn't have a medical definition. If you have any questions related to medical topics or definitions, I'd be happy to try to help answer them!
I'm sorry for any confusion, but "Israel" is a country in the Middle East and does not have a medical definition. If you have any medical questions or terms you would like me to define, I'd be happy to help!
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
An individual having different alleles at one or more loci regarding a specific character.
Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.

Age estimates of two common mutations causing factor XI deficiency: recent genetic drift is not necessary for elevated disease incidence among Ashkenazi Jews. (1/81)

The type II and type III mutations at the FXI locus, which cause coagulation factor XI deficiency, have high frequencies in Jewish populations. The type III mutation is largely restricted to Ashkenazi Jews, but the type II mutation is observed at high frequency in both Ashkenazi and Iraqi Jews, suggesting the possibility that the mutation appeared before the separation of these communities. Here we report estimates of the ages of the type II and type III mutations, based on the observed distribution of allelic variants at a flanking microsatellite marker (D4S171). The results are consistent with a recent origin for the type III mutation but suggest that the type II mutation appeared >120 generations ago. This finding demonstrates that the high frequency of the type II mutation among Jews is independent of the demographic upheavals among Ashkenazi Jews in the 16th and 17th centuries.  (+info)

Age estimate of the N370S mutation causing Gaucher disease in Ashkenazi Jews and European populations: A reappraisal of haplotype data. (2/81)

The N370S mutation at the GBA locus on human chromosome 1q21, which causes Gaucher disease (GD), has a high frequency in the Ashkenazim and is the second-most-widespread GD mutation in the European non-Jewish population. A common ancient origin for the N370S mutation in the Ashkenazi Jewish and Spanish populations has been proposed on the basis of both a similar haplotype for associated markers and an age estimate that suggests that this mutation appeared several thousand years ago. However, a reappraisal of haplotype data, using the Risch formula properly along with a Luria-Delbruck setting of the genetic clock, allows identification of the likely origin of the N370S mutation in Ashkenazi Jews between the 11th and 13th centuries. This result is consistent with the estimated ages of other mutations that are frequent among Ashkenazim, with the exception of type II (Glu117Stop) factor XI deficiency, which is deemed to be >3000 years old, predating the separation of the Ashkenazi and Iraqi Jews. The present finding supports the hypothesis of a more recent origin for the N370S mutation and is consistent with both a founder chromosome transfer from Ashkenazim who assimilated in some European populations and a non-Jewish origin of the European N370S-bearing chromosomes.  (+info)

Simple screening tests for the diagnosis of isolated clotting factor defects. With special reference to 'contact factor' defects. (3/81)

Reagents may be prepared from normal plasma and used with the prothrombin time and partial thromboplastin time tests to distinguish isolated defects of factors I, II, VII, VIII, IX, X, XI, or XII.  (+info)

The characterization of mice with a targeted combined deficiency of protein c and factor XI. (4/81)

Activated protein C functions directly as an anticoagulant and indirectly as a profibrinolytic enzyme. To determine whether the fibrin deposition previously observed in PC(-/-) murine embryos and neonates was mediated through the FXI pathway, PC(+/-)/FXI(-/-) mice were generated and crossbred to produce double-deficient progeny (PC(-/-)/FXI(-/-)). PC(-/-)/FXI(-/-) mice survived the early lethality observed in the PC(-/-)/FXI(+/+) neonates, with the oldest PC(-/-)/FXI(-/-) animal living to 3 months of age. However, the majority of these animals was sedentary and significantly growth-retarded. On sacrifice or natural death, all of these PC(-/-)/FXI(-/-) mice demonstrated massive systemic fibrin deposition with concomitant hemorrhage and fibrosis, as confirmed through histological analyses. Several of these animals also presented with enlarged lymph nodes and extensive lymphatic fluid in the thoracic cavity. Thus, although a number of the PC(-/-)/FXI(-/-) mice survived the lethal perinatal coagulopathy seen in the PC(-/-) neonates, they nonetheless succumbed to overwhelming thrombotic disease in later life. This combined deficiency state provided the first clear indication that the course of a severe thrombotic disorder could be manipulated by blocking the intrinsic pathway and provided the first opportunity to study a total protein C deficiency in an adult animal.  (+info)

Defective binding of factor XI-N248 to activated human platelets. (5/81)

Variants of factor XI containing Gln226 to Arg (Q226 to R) and Ser248 to Asn (S248 to N) substitutions were first identified in an African American family with a history of excessive bleeding. The substitutions have recently been identified in unrelated individuals, suggesting they are relatively common. Both amino acids are located in the third apple domain of factor XI, an area implicated in binding interactions with factor IX and activated platelets. Recombinant factor XI-R226 and factor XI-N248 were compared with wild-type factor XI in assays for factor IX activation or platelet binding. Factor XI-R226 activates factor IX with a Michaelis-Menten constant (K(m)) about 5-fold greater than wild-type protein. The catalytic efficiency of factor IX activation is similar to wild-type protein, however, due to an increase in the turnover number (k(cat)) for the reaction. Iodinated factor XI-N248 binds to activated platelets with a dissociation constant (K(d)) more than 5-fold higher than wild-type protein (55 nM and 10 nM, respectively). Activation of factor XI-N248 by thrombin in the presence of activated platelets is slower and does not progress to the same extent as activation of the wild-type protein under similar conditions. Factor XI-N248 activates factor IX normally in a purified protein system and has relatively normal activity in activated partial thromboplastin time (aPTT) assays. Factor XI-N248 is the first factor XI variant described with a clear functional difference compared with wild-type protein. Importantly, the defect in platelet binding would not be detected by routine clinical evaluation with an aPTT assay.  (+info)

Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene. (6/81)

Inherited factor XI deficiency is an injury-related bleeding disorder that is rare in most populations except for Jews, in whom 2 mutations, a stop mutation in exon 5 (type II) and a missense mutation in exon 9 (type III), predominate. Recently, a cluster of 39 factor XI-deficient patients was described in the Basque population of Southwestern France. In this study, we determined the molecular basis of factor XI deficiency in 16 patients belonging to 12 unrelated families of French Basque origin. In 8 families, a nucleotide 209T>C transition in exon 3 was detected that predicts a Cys38Arg substitution. Four additional novel mutations in the factor XI gene, Cys237Tyr, Tyr493His, codon 285delG, and IVS6 + 3A>G, were identified in 4 families. Expression studies showed that Cys38Arg and Cys237Tyr factor XI were produced in transfected baby hamster kidney cells, but their secretion was impaired. Cells transfected with Tyr493His contained reduced amounts of factor XI and displayed decreased secretion. A survey of 206 French Basque controls for Cys38Arg revealed that the prevalence of the mutant allele was 0.005. Haplotype analysis based on the study of 10 intragenic polymorphisms was consistent with a common ancestry (a founder effect) for the Cys38Arg mutation.  (+info)

Factor XI deficiency in Iranians: its clinical manifestations in comparison with those of classic hemophilia. (7/81)

BACKGROUND AND OBJECTIVES: Patients affected by Hodgkin's disease (HD) resistant to induction therapy or who have a brief duration of first remission have a poor outcome. DESIGN AND METHODS: We retrospectively reviewed the clinical data of 28 patients affected by Hodgkin's disease who relapsed 6 to 24 months from completion of treatment (14 patients) or who were refractory to first-line therapy or relapsed very early (14 patients). All the 28 patients were treated with salvage chemotherapy plus a conditioning regimen followed by peripheral blood stem cell transplant (PBCST) or autologous bone marrow transplant (ABMT). RESULTS: At a median follow-up of 35.5 months (range 14-119), of the 14 patients responding to first-line therapy but who relapsed > 6 months off therapy, 10 (72%) are alive, well and in complete remission (CR), 2 (14%) are alive with disease at 39 and 83 months from transplant, and 2 (14%) died 26 and 63 months after their transplant from acute myeloid leukemia and HD, respectively. At a median follow-up of 39 months, the overall survival (OS) is 68% and the event-free survival (EFS) is 56%. At a median follow-up of 30 months (1-98), of the 14 patients refractory to first-line therapy or who relapsed very early, 9 (64%) are alive in CR, 1 (7%) is alive with disease and 4 (29%) have died of their disease (3 patients) or myelodysplastic syndrome (1 patient). The OS is 58% and the EFS is 52%. There are no statistically significant differences in terms of OS and EFS between the two groups of patients. INTERPRETATION AND CONCLUSIONS: Our study shows that salvage chemotherapy followed by a conditioning regimen and autotransplant is an effective, feasible and well-tolerated scheme of therapy not only for patients with HD who relapse after first-line treatment, but also for those resistant to first-line treatment.  (+info)

Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency. (8/81)

Factor XI deficiency, an injury-related bleeding disorder, is rare worldwide but common in Jews in whom 2 mutations, Glu117Stop (type II) and Phe283Leu (type III), prevail. Mean factor XI activities in homozygotes for Glu117Stop and for Phe283Leu are 1 and 10 U/dL, respectively. Inhibitors to factor XI in patients with severe factor XI deficiency have been reported in a small number of instances. This study was undertaken to determine the prevalence of acquired inhibitors against factor XI in patients with severe factor XI deficiency, discern whether these inhibitors are related to specific mutations, and characterize their activity. Clinical information was obtained from unrelated patients with severe factor XI deficiency, and blood was analyzed for factor XI activity, inhibitor to factor XI, and causative mutations. Immunoglobulin G purified from patients with an inhibitory activity was tested for binding to factor XI, effects on activation of factor XI by factor XIIa and thrombin, and activation of factor IX by exogenous factor XIa. Of 118 Israeli patients, 7 had an inhibitor; all belonged to a subgroup of 21 homozygotes for Glu117Stop who had a history of plasma replacement therapy. Three additional patients with inhibitors from the United Kingdom and the United States also had this genotype and were exposed to plasma. The inhibitors affected factor XI activation by thrombin or factor XIIa, and activation of factor IX by factor XIa. The results imply that patients with a very low factor XI level are susceptible to development of an inhibitor following plasma replacement.  (+info)

Factor XI deficiency, also known as Hemophilia C or Rosenthal syndrome, is a rare bleeding disorder caused by a deficiency or dysfunction of coagulation factor XI. This protease plays an important role in the intrinsic pathway of blood coagulation. Factor XI deficiency can lead to prolonged bleeding after surgery, trauma, or menstruation, but it typically does not cause spontaneous bleeding like Hemophilia A and B. The severity of the condition varies widely among affected individuals. Inheritance is autosomal recessive, meaning that two defective copies of the gene (one from each parent) are necessary to have the disease.

Factor XI, also known as plasma thromboplastin antecedent (PTA) or antihemophilic factor C, is a protein involved in blood coagulation. It is one of the factors in the intrinsic pathway of coagulation, which is activated when blood comes into contact with negatively charged surfaces, such as damaged blood vessels.

When Factor XI is activated (usually by thrombin or activated Factor XII), it activates more Factor XI and also activates Factor IX, leading to the formation of a complex that converts Factor X to its active form, Factor Xa. This ultimately leads to the formation of a fibrin clot and helps to stop bleeding.

Deficiencies in Factor XI can lead to an increased risk of bleeding, although the severity of the bleeding disorder can vary widely among individuals with Factor XI deficiency. Treatment for Factor XI deficiency typically involves replacement therapy with fresh frozen plasma or recombinant Factor XI concentrate.

"Modern History (1601-)" is a term used in medicine to refer to the historical context of medical developments and practices that have occurred from the early 17th century until the present day. This period is characterized by significant advancements in medical knowledge, technology, and treatment methods.

Some notable events and developments in modern medical history include:

* The establishment of the Royal Society in London in 1660, which promoted scientific inquiry and discovery.
* The invention of the microscope in the 17th century, which allowed for the discovery of cells and microorganisms.
* The development of vaccines in the late 18th century by Edward Jenner, which revolutionized public health and prevented many infectious diseases.
* The discovery of anesthesia in the mid-19th century, which made surgical procedures less painful and more effective.
* The development of antibiotics in the early 20th century, which transformed the treatment of bacterial infections.
* The advent of modern medical imaging technologies such as X-rays, CT scans, and MRIs, which have improved diagnostic accuracy and surgical precision.
* The mapping of the human genome in the late 20th century, which has opened up new avenues for genetic research and personalized medicine.

Understanding the historical context of modern medical developments is essential for healthcare professionals to appreciate the evolution of medical practices, identify ongoing challenges and areas for improvement, and provide high-quality care to their patients.

I'm sorry for any confusion, but "Jews" is not a medical term. It is a term used to describe a group of people who share cultural, religious, and ethnic heritage. The Jewish people originated from the ancient kingdoms of Israel and Judah. They are bound together by their religion, Judaism, which is based on the Torah, or the five books of Moses.

If you have any medical questions or terms that you would like defined, I'd be happy to help!

I'm sorry for any confusion, but "Iraq" is not a medical term. It is a country located in the Middle East. If you have any medical questions or terms you would like defined, I would be happy to help!

I'm sorry for any confusion, but "Israel" is not a medical term. It is a country located in the Middle East. If you have any medical questions or terms you would like defined, I would be happy to help!

Partial Thromboplastin Time (PTT) is a medical laboratory test that measures the time it takes for blood to clot. It's more specifically a measure of the intrinsic and common pathways of the coagulation cascade, which are the series of chemical reactions that lead to the formation of a clot.

The test involves adding a partial thromboplastin reagent (an activator of the intrinsic pathway) and calcium to plasma, and then measuring the time it takes for a fibrin clot to form. This is compared to a control sample, and the ratio of the two times is calculated.

The PTT test is often used to help diagnose bleeding disorders or abnormal blood clotting, such as hemophilia or disseminated intravascular coagulation (DIC). It can also be used to monitor the effectiveness of anticoagulant therapy, such as heparin. Prolonged PTT results may indicate a bleeding disorder or an increased risk of bleeding, while shortened PTT results may indicate a hypercoagulable state and an increased risk of thrombosis.

Cattle diseases are a range of health conditions that affect cattle, which include but are not limited to:

1. Bovine Respiratory Disease (BRD): Also known as "shipping fever," BRD is a common respiratory illness in feedlot cattle that can be caused by several viruses and bacteria.
2. Bovine Viral Diarrhea (BVD): A viral disease that can cause a variety of symptoms, including diarrhea, fever, and reproductive issues.
3. Johne's Disease: A chronic wasting disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It primarily affects the intestines and can cause severe diarrhea and weight loss.
4. Digital Dermatitis: Also known as "hairy heel warts," this is a highly contagious skin disease that affects the feet of cattle, causing lameness and decreased productivity.
5. Infectious Bovine Keratoconjunctivitis (IBK): Also known as "pinkeye," IBK is a common and contagious eye infection in cattle that can cause blindness if left untreated.
6. Salmonella: A group of bacteria that can cause severe gastrointestinal illness in cattle, including diarrhea, dehydration, and septicemia.
7. Leptospirosis: A bacterial disease that can cause a wide range of symptoms in cattle, including abortion, stillbirths, and kidney damage.
8. Blackleg: A highly fatal bacterial disease that causes rapid death in young cattle. It is caused by Clostridium chauvoei and vaccination is recommended for prevention.
9. Anthrax: A serious infectious disease caused by the bacterium Bacillus anthracis. Cattle can become infected by ingesting spores found in contaminated soil, feed or water.
10. Foot-and-Mouth Disease (FMD): A highly contagious viral disease that affects cloven-hooved animals, including cattle. It is characterized by fever and blisters on the feet, mouth, and teats. FMD is not a threat to human health but can have serious economic consequences for the livestock industry.

It's important to note that many of these diseases can be prevented or controlled through good management practices, such as vaccination, biosecurity measures, and proper nutrition. Regular veterinary care and monitoring are also crucial for early detection and treatment of any potential health issues in your herd.

A heterozygote is an individual who has inherited two different alleles (versions) of a particular gene, one from each parent. This means that the individual's genotype for that gene contains both a dominant and a recessive allele. The dominant allele will be expressed phenotypically (outwardly visible), while the recessive allele may or may not have any effect on the individual's observable traits, depending on the specific gene and its function. Heterozygotes are often represented as 'Aa', where 'A' is the dominant allele and 'a' is the recessive allele.

Factor XIa is a serine protease enzyme that plays a crucial role in blood coagulation. It is formed through the activation of Factor XI, which is one of the key components in the intrinsic pathway of the coagulation cascade. The activation of Factor XI to Factor XIa occurs via either autoactivation or through the action of thrombin. Once activated, Factor XIa can cleave and activate Factor IX, leading to the formation of Factor IXa, which further amplifies the coagulation cascade.

In summary, Factor XIa is a vital enzyme in the blood coagulation process, contributing to the formation of a stable fibrin clot that helps prevent excessive bleeding during injury or trauma.

... allowing factor XI's protease activity on it. Deficiency of factor XI causes the rare hemophilia C; this mainly occurs in ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ...
... factor XI deficiency) is centered on prolonged activated partial thromboplastin time (aPTT). One will find that the factor XI ... "Orphanet: Congenital factor XI deficiency Hemophilia C". www.orpha.net. Retrieved 2016-07-12. Orkin, Stuart H.; Nathan, David G ... "OMIM Entry - # 612416 - FACTOR XI DEFICIENCY". omim.org. Retrieved 2016-07-12. Kitchens, Craig S.; Konkle, Barbara A.; Kessler ... "Factor XI Deficiency: Background, Pathophysiology, Epidemiology". 2018-07-02. {{cite journal}}: Cite journal requires ,journal ...
Factor XI (FXI) is a serine protase produced by the liver and circulates in its inactive form. Deficiency in factor XI is known ... "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". The ... Bolton-Maggs PH (June 1996). "Factor XI deficiency". Baillière's Clinical Haematology. 9 (2): 355-68. doi:10.1016/s0950-3536(96 ... Factor XIIa is another plasma protein that is involved in the activation of zymogen factor is activated into factor XIa. This ...
O'Connell NM (Jun 2003). "Factor XI deficiency--from molecular genetics to clinical management". Blood Coagulation & ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell ... Deficiency of factor IX causes Christmas disease (hemophilia B). Over 3000 variants of factor IX have been described, affecting ...
Al-Fadhil, Nawal; Pathare, Anil; Ganesh, Anuradha (2001-10-01). "Traumatic Hyphema and Factor XI Deficiency (Hemophilia C)". ... Factor VIII is used in haemophilia A and factor IX in haemophilia B. Factor replacement can be either isolated from human blood ... The type of haemophilia known as parahaemophilia is a mild and rare form and is due to a deficiency in factor V. This type can ... Other types include haemophilia C, which occurs due to low levels of factor XI, Von Willebrand disease, which occurs due to low ...
Not to be confused with Rosenthal syndrome a.k.a. hemophilia C which is caused by clotting factor XI deficiency. Only genetic ...
Factor XIII Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S, et al. (2015). "Factor XIII Deficiency in ... "Recombinant Factor XIII". 2010. "Factor XIII". 2014-03-05. Muszbek, Laszlo; et al. (1999). "Blood coagulation factor XIII: ... "Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency". ... Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. The incidence is one in a million to one ...
... partial deficiency of factor VIII:C, partial deficiency of factor XI:C, partial deficiency of factor XII:C, and an imbalance of ... resemble that of the general population and treatment of bleeding diathesis is guided by the specific factor deficiency or ... Additional factors may present in the form of winging of the scapula, scoliosis, breast bone prominence (pectus carinatum), ... 28 (11): 752-756. doi:10.1136/jmg.28.11.752. ISSN 0022-2593. PMC 1017110. PMID 1770531. Armour, C. M.; Allanson, J. E. (April ...
... alpha-1 antitrypsin deficiency, glucose-6-phosphate dehydrogenase deficiency, early-onset of dystonia, factor XI deficiency, ... identifying mutations in the gene that codes for glucocerebrosidase as a risk factor for Parkinson's disease. In 2015, 23andMe ... June 11, 2010. Retrieved November 27, 2013. Pollack, Andrew (June 11, 2010). "F.D.A. Faults 5 Companies on Genetic Tests". The ... Tsotsis, Alexia (December 11, 2012). "Another $50M Richer, 23andMe Drops Its Price To $99 Permanently. But Will The Average ...
... or factor XI deficiency. As a result, the main concern related to factor XII deficiency is the unnecessary testing, delay in ... Unlike other clotting factor deficiencies, factor XII deficiency is totally asymptomatic and does not cause excess bleeding. ... Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC ... who found that Hageman lacked a previously unidentified clotting factor. Ratnoff later found that the Hageman factor deficiency ...
In rare cases, inherited bleeding disorders, like hemophilia, von Willebrand disease (vWD), or factor IX or XI deficiency, may ... Another bleeding risk factor is thrombocytopenia, or decreased platelet levels, which is the most common hematological change ... This pathology occurs due to the normal physiological drop in maternal clotting factors after delivery which greatly increases ... 11 (4): e0152408. Bibcode:2016PLoSO..1152408A. doi:10.1371/journal.pone.0152408. PMC 4822885. PMID 27050823. Global burden of ...
Deficiencies of factors VIII, IX, XI and XII and rarely von Willebrand factor (if causing a low factor VIII level) may lead to ... anti-hemophilic factor), X (Stuart-Prower factor), XI (plasma thromboplastin antecedent), and XII (Hageman factor). The PTT is ... Normal PTT requires the presence of the following coagulation factors: I, II, V, VIII, IX, X, XI and XII. Notably, deficiencies ... coagulation factor deficiency (e.g., hemophilia) sepsis - coagulation factor consumption presence of antibodies against ...
However, other research suggests that scurvy (vitamin C deficiency) and environmental factors also contributed to their deaths ... He died eleven years later, aged 33, never having fully recovered his health. He is buried in the Melbourne General Cemetery. ... Part XI: vii. 1867. "The Funeral of Burke and Wills". The Argus: 5. 22 January 1863. Retrieved 24 July 2020. Holm, Janet (2005 ... As a result, it is likely that the deaths of Burke and Wills resulted in part from a vitamin deficiency disease called beriberi ...
"Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency". Frontiers in Immunology. 11: ... Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in ... Yu Z, Song YB, Cui Y, Fu AQ (July 2019). "Effects of AIF-1 inflammatory factors on the regulation of proliferation of breast ... Allograft Inflammatory Factor 1 is found in activated macrophages. Activated macrophages are found in tissues with inflammation ...
2020-10-21). "Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency". Frontiers in Immunology. 11: ... In humans, RAG deficiency was first recognised as a form of immune dysregulation known as Omenn syndrome. RAG deficiency is ... such as antibody deficiency, Idiopathic CD4+ T lymphopenia or vasculitis. RAG deficiency can be measured by in vitro ... Geier CB, Piller A, Linder A, Sauerwein KM, Eibl MM, Wolf HM (2015-07-17). Rieux-Laucat F (ed.). "Leaky RAG Deficiency in Adult ...
... factor XI deficiency, von Willebrand disease, fibrinogen disorders and Bernard-Soulier syndrome Treatment is given ... and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). Haemophilia B was ... Factor IX when activated activates factor X which helps fibrinogen to fibrin conversion. Factor IX becomes active eventually in ... Factor IX deficiency leads to an increased propensity for haemorrhage, which can be either spontaneously or in response to mild ...
... because it is not influenced by deficiencies in clotting factors VIII, IX or XI. Shaw, George (1797). "The Russelian Snake". ... The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and ... 11 (3): 384-5. Silva A de (1990). Colour Guide to the Snakes of Sri Lanka. Avon (Eng): R & A Books. ISBN 1-872688-00-4. 130 pp ... pp 11-17. Jena I, Sarangi A (1993). Snakes of Medical Importance and Snake-bite Treatment. New Delhi: SB Nangia, Ashish ...
... hemophilia B with a deficiency in factor IX (Christmas disease), and hemophilia C with a deficiency in factor XI. Other rare ... Factor XII deficiency is a deficiency in the production of factor XII (FXII), a plasma glycoprotein and clotting factor that ... "Factor XII Deficiency" (PDF). Pathology, Virginia Commonwealth University. Retrieved February 20, 2017. "Factor XII Deficiency ... Hageman factor) deficiency among the normal population: evaluation of the incidence of FXII deficiency among 300 healthy blood ...
doi:10.2147/vhrm.s5305 "Factor I deficiency (Fibrinogen deficiency) - Canadian Hemophilia Society". www.hemophilia.ca. ... Alternatively, cryoprecipitate contains other coagulation factors, factors VIII, XIII, and von Willebrand factor. There are no ... Factor I Deficiency Neerman-Arbez, Marguerite; De Moerloose, Philippe (2007). "Mutations in the fibrinogen gene cluster ... The only risk factor is if both parents of a child carry the recessive allele linked to the disorder.[citation needed] ...
Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142-7. PMID 1403646. Maruyama K, Sugano S (January 1994). "Oligo- ... increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor ... 11 (10): 1315-26. doi:10.1101/gad.11.10.1315. PMID 9171375. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N ( ... 19 (11): 7697-704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658. Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, ...
This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor ... Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142-7. PMID 1403646. v t e (Articles with short description, Short ... 19 (11): 7697-704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, ... 11 (10): 1315-26. doi:10.1101/gad.11.10.1315. PMID 9171375. "Entrez Gene: POLR3F polymerase (RNA) III (DNA directed) ...
"HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes & Development. 6 (4): ... Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142-7. PMID 1403646. Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen ... increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor ...
Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142-7. PMID 1403646. Wang, Z; Roeder, R. G. (1997). "Three human RNA ... increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor ... 11 (10): 1315-26. doi:10.1101/gad.11.10.1315. PMID 9171375. Hu, P; Wu, S; Sun, Y; Yuan, C. C.; Kobayashi, R; Myers, M. P.; ...
PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor). Prekallikrein is homologous to factor XI, and ... The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed "Fletcher factor" after the family ... However, unlike factor XI, prekallikrein does not form dimers. Prekallikrein is activated to form kallikrein by factor XII ... cleavage of a bond homologous to the corresponding bond cleaved during factor XI activation. Hereditary deficiencies in PK are ...
... because it is not influenced by deficiencies or inhibitors of clotting factors VIII, IX or XI as the venom mainly activates ... The venom contains the enzymes RVV-V and RVV-X which activate factor V and factor X, which converts prothrombin into thrombin ... one would expect the clotting time to be significantly shortened if there was only a deficiency of coagulation factors alone. A ... RVV came to be useful in laboratory tests for blood clotting factors V, X, prothrombin and phospholipid. It was first used in ...
All these factors are currently believed to contribute to global reserve. Cognitive reserve is commonly used to refer to both ... Journal of Acquired Immune Deficiency Syndromes. 6 (5): 503-11. doi:10.1097/00126334-199305000-00011. PMID 8483113. Wilson RS, ... Studies use factors like education, occupation, and lifestyle as proxies for cognitive reserve because they tend to positively ... Due to the variety of the four lifestyle factors, a lot of different self-report-scales are used to specify the severity of ...
... congenital Factor X deficiency Factor XI deficiency, congenital Factor XIII deficiency, congenital Factor XIII deficiency ... II deficiency Factor V deficiency Factor V Leiden mutation Factor VII deficiency Factor VIII deficiency Factor X deficiency, ... 6-bisphosphatase deficiency Fructose-1-phosphate aldolase deficiency, heredita Fructosemia, hereditary Fructosuria Frydman- ... with nephrocalcinosis and renal stones Fanconi anemia Fara-Chlupackova syndrome Farber's disease Farmer's lung Fas deficiency ...
"Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/ ... Neutrophil-specific granule deficiency ( previously known as lactoferrin deficiency) is a rare congenital immunodeficiency ... Khanna-Gupta A, Sun H, Zibello T, Lee HM, Dahl R, Boxer LA, Berliner N (2007). "Growth factor independence-1 (Gfi-1) plays a ... Breton-Gorius J, Mason DY, Buriot D, Vilde JL, Griscelli C (1980). "Lactoferrin deficiency as a consequence of a lack of ...
"Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency". Frontiers in Immunology. 11: 574738. doi: ... These include adenosine deaminase 2 deficiency and haploinsufficiency of A20. According to the size of the vessel affected, ... Meyts, Isabelle; Aksentijevich, Ivona (July 2018). "Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, ... and RAG deficiency Exposure to chemicals and drugs, such as amphetamines, cocaine, and anthrax vaccines which contain the ...
Acquired cases are results from an isolated factor II deficiency. Specific cases include: Vitamin K deficiency: In the liver, ... Factor assays: To observe the performance of specific factors (II) to identify missing/poorly performing factors. These lab ... "Factor II Deficiency". DoveMed. Retrieved 2017-12-12. Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D (1983). "A mechanism ... Vitamin K-dependent coagulation factors have a very short half-life, sometimes leading to a deficiency when a depletion of ...
Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C ( ... deficiency is an autosomal disorder that may be associated with bleeding. ... encoded search term (Factor XI Deficiency) and Factor XI Deficiency What to Read Next on Medscape ... Factor XI deficiency. Diagram from the traditional cascade-waterfall model of coagulation shows the place of factor XI in the ...
Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C ( ... deficiency is an autosomal disorder that may be associated with bleeding. ... encoded search term (Factor XI Deficiency) and Factor XI Deficiency What to Read Next on Medscape ... Factor XI deficiency. Diagram from the traditional cascade-waterfall model of coagulation shows the place of factor XI in the ...
Gynaecological and obstetrical bleeding in women with factor XI deficiency - a systematic review. In: Haemophilia. 2016 ; Vol. ... Gynaecological and obstetrical bleeding in women with factor XI deficiency - a systematic review. Haemophilia. 2016 Mar;22(2): ... Gynaecological and obstetrical bleeding in women with factor XI deficiency - a systematic review. / Wiewel-Verschueren, S.; ... title = "Gynaecological and obstetrical bleeding in women with factor XI deficiency - a systematic review", ...
Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C ( ... deficiency is an autosomal disorder that may be associated with bleeding. ... encoded search term (Factor XI Deficiency) and Factor XI Deficiency What to Read Next on Medscape ... Inherited deficiencies of coagulation factors II, V, VII, XI, and XIII and the combined deficiencies of factors V and VIII and ...
Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C ( ... deficiency is an autosomal disorder that may be associated with bleeding. ... encoded search term (Factor XI Deficiency) and Factor XI Deficiency What to Read Next on Medscape ... Inherited deficiencies of coagulation factors II, V, VII, XI, and XIII and the combined deficiencies of factors V and VIII and ...
BACKGROUND Factor XI deficiency, also known as hemophilia C, is a rare inherited bleeding disorder that may leave routine ... BACKGROUND Factor XI deficiency, also known as hemophilia C, is a rare inherited bleeding disorder that may leave routine ... Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case. Cristina ... Factor XI deficiency and delayed hemorrhages after resection of choroid plexus papilloma: illustrative case / Mancarella, ...
... Asselta R;Paraboschi E;Rimoldi V; ... Factor XI (FXI) deficiency is an autosomal bleeding disorder, usually posttrauma or postsurgery, characterized by reduced ... Factor XI (FXI) deficiency is an autosomal bleeding disorder, usually posttrauma or postsurgery, characterized by reduced ... the calculated prevalence of the severe deficiency in Europeans would be: 12.9 in 106). In addition, this analysis allowed us ...
An hereditary deficiency in Factor XI can result in a lifelong bleeding disorder or go undetected. ... 3) decreased Factor XI activity by specific assay. (4) The assay for Factor XI may be falsely elevated if the blood sample is ... An hereditary deficiency in Factor XI can result in a lifelong bleeding disorder or go undetected. ... Clinical Findings in a Patient with an Hereditary Deficiency of Factor XI ...
Kılıç, S.Ç., İçağasıoğlu, F.D., Güven, A.S., Berber, E. (2014).Spontaneous thrombosis in a patient with factor XI deficiency ... Spontaneous thrombosis in a patient with factor XI deficiency homozygous for the p.Cys398Tyr mutation. ...
... allowing factor XIs protease activity on it. Deficiency of factor XI causes the rare hemophilia C; this mainly occurs in ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ...
Cross-species summary: Congenital factor XI deficiency / F11 deficiency is an inherited bleeding disorder characterized by ... Factor XI deficiency in Kerry Blue Terriers Journal of the American Veterinary Medical Association 205:1557-1561, 1994. Pubmed ... Factor XI deficiency in animal models. J Thromb Haemost 7 Suppl 1:79-83, 2009. Pubmed reference: 19630774 . DOI: 10.1111/j.1538 ... Molecular base of coagulation factor XI deficiency in Kerry Blue terrier. Bulgarian Journal of Veterinary Medicine 10:247-255, ...
Transfusion-Induced Specific Anti-Factor XI Inhibitor in a Patient with Previously Unrecognized Factor XI Deficiency Journal ... XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. ... The IgG fraction of the patients plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel ... It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial ...
... factor XII, high-molecular-weight kininogen (HK), and prekallikrein (PK). Factor XI is synthesized in the liver and ... The so-called contact factors include factor XI, ... Factor XI is warranted when a deficiency of factor XI is ... Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds. Blood ... In mice, knockout of the gene for factor XI does not lead to death in utero. [9] In humans, however, factor XI deficiencies can ...
F10 deficiency, see Factor X deficiency. *F11 deficiency, see Factor XI deficiency ... Fibrin stabilizing factor deficiency, see Factor XIII deficiency. *Fibrinoid degeneration of astrocytes, see Alexander disease ... Familial LCAT deficiency, see Complete LCAT deficiency. *Familial lecithin-cholesterol acyltransferase deficiency, see Complete ... Familial isolated vitamin E deficiency, see Ataxia with vitamin E deficiency. *Familial juvenile hyperuricemic nephropathy, see ...
Factor XI deficiency (a blood-clotting disorder). *Gaucher disease type 1 (an organ and tissue disorder) ... "Theres a number of other factors that come into play when youre looking at your susceptibility of getting a disease, and ... Genetics isnt the only factor. There are many things other than genetic variants that can contribute to the development of ... Alpha-1 antitrypsin deficiency (a disorder that could cause lung disease and liver disease) ...
keywords = "Bleeding, Factor XI, Factor XI deficiency, Fibrin clot lysis time, Plasma clot lysis time", ... N2 - Background: Factor XI (FXI) deficiency is a rare autosomal recessive disorder. Many patients with even very low FXI levels ... AB - Background: Factor XI (FXI) deficiency is a rare autosomal recessive disorder. Many patients with even very low FXI levels ... Background: Factor XI (FXI) deficiency is a rare autosomal recessive disorder. Many patients with even very low FXI levels (, ...
A relatively potent antiserum against highly purified, unactivated human factor XI antigen was raised in a rabbit. This ... Factor XI activity and factor XI antigen in homozygous and heterozygous factor XI deficiency A Rimon, A Rimon ... Severity of bleeding in factor XI deficiency could not be correlated with the level of factor XI activity or factor XI antigen. ... Factor XI activity and factor XI antigen in homozygous and heterozygous factor XI deficiency. Blood 1976; 48 (2): 165-174. doi ...
factor XI deficiency, a blood-clotting disorder. *Gaucher disease type 1, an organ and tissue disorder ... Alpha-1 antitrypsin deficiency, which can lead to lung and liver disease ... glucose-6-phosphate dehydrogenase deficiency, a red blood cell condition. *hereditary hemochromatosis, an iron overload ... Many conditions need both genetic and environmental or lifestyle factors to develop. ...
Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy. D. ... A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation. V. Baeriswyl; S. Calzavarini; S. Chen; A ... Peptide macrocycle inhibitor of coagulation factor XII with subnanomolar affinity and high target selectivity. S. J. Middendorp ... Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe ...
Hereditary factor XI deficiency disease MedGen: C0015523 OMIM: 612416 GeneReviews: Not available ... coagulation factor XI. Names. coagualtion factor XI. plasma thromboplastin antecedent. NP_000119.1. *EC 3.4.21.27 ... Coagulation Factor XI / FXI / F11 Antibody, Rabbit PAb * Coagulation Factor XI / FXI / F11 Antibody, Rabbit PAb, Antigen ... F11 coagulation factor XI [Homo sapiens] F11 coagulation factor XI [Homo sapiens]. Gene ID:2160 ...
Everything You Need to Know About Hemophilia C (Factor XI Deficiency). Learn about how you can inherit hemophilia C, a rare ...
Factor XI deficiency. F11. CNV. Prothrombin deficiency. F2. CNV. Hemophilia A. F8. CNV. ... Short chain acyl-CoA dehydrogenase deficiency. ACADS. CNV. Short/branched chain acyl-CoA dehydrogenase deficiency. ACADSB. CNV ... Corticosterone methyloxidase deficiency. CYP11B2. CNV. Congenital adrenal hyperplasia, 17-alpha-hydroxylase deficiency. CYP17A1 ... 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency. PTS. CNV. Mitochondrial myopathy and sideroblastic anemia (MLASA1). ...
Could factor XI inhibitors be the long-sought answer? ... suggesting that patients with a genetic factor XI deficiency ... Why Factor XI? The hope that factor XI inhibitors will prevent pathologic thrombosis with a lower bleeding risk compared to ... The three factor XI inhibitors also have some differences. Ruff points out that most important will be the safety and efficacy ... "It has been discovered that factor XI has a really unique position in the cascade of how our body forms clots in that it seems ...
Factor XI Deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice. PLoS ... Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation. Thromb ... Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. J Leukoc Biol. 2011;90(5):923-927.. View this article ... The skin window as a monitor of leukocytic functions in contact activation factor deficiencies in man. Am J Clin Pathol. 1983; ...
Factor XI deficiency protects against atherogenesis in apolipoprotein E/Factor XI double knockout mice. Arterioscler Thromb ... Apo, apolipoprotein; KO, knockout; ApoE/FXI DKO, ApoE/factor XI double KO; FXI, factor XI. ... FXI deficiency reduces the aortic atherosclerotic burden, and similar to ApoE KO mice, ApoE/factor XI double KO (ApoE/FXI DKO) ... Duga S and Salomon O: Congenital factor XI deficiency: An update. Semin Thromb Hemost. 39:621-631. 2013. View Article : Google ...
29.10.2009 Genetic Factor XI Deficiency in Holstein Cows in Japan. *27.10.2009 Epithelioid cells in bovine lymph nodes without ... 11.01.2005 Mutation associated with factor XI deficiency in Holstein cattle*03.01.2005 Caudal epidural xylazine in Holstein ... 23.10.2016 Oral direct factor Xa inhibitor anticoagulant in healthy adult horses. *21.10.2016 Geochemical risk factors for ... 31.10.2010 Risk factors for post-weaning mortality in Australian sheep. *01.10.2010 Myxoma of the lung in a sheep (case report) ...
We know that individuals that are born with whats called a factor XI deficiency have a decreased risk of having venous ... This is the study of a new factor XI inhibitor that can be given orally. They tested it in people that are having knee surgery ... In over 1,200 patients, they gave half of them this new factor XI inhibitor called milvexian. What they found out is it was ... Maybe if we made an inhibitor to factor XI we could get the same results. We need something thats given orally." ...
Acquired Agranulocytosis and Factor XI Deficiency in Association With Thymoma. Jethava, Y., Alamelu, J., Rangarajan, S., Lang- ...
A 78-year-old man with homozygous factor XI deficiency and an extensive medical history, including coronary artery disease, ... The patient also received 14 plasma transfusions to keep his factor XI levels above the hemostatic threshold. ... As an inpatient, he received a diagnosis of iron deficiency; his serum iron level was 13 (reference range 65-175 μg/dL). ... 11). HGA symptoms typically appear 5-21 days after a tick bite and manifest as fever (75%-100%), myalgia (75%), headache (83 ...
  • unlike the soft tissue bleeds and hemarthroses that characterize hemophilia A and B, abnormal bleeding in FXI deficiency typically involves mucosal tissues, which are rich in fibrinolytic activity (eg, the oral and nasal cavities and urinary tract). (medscape.com)
  • The coagulation defect in plasma from these patients was corrected on mixing with plasma from patients with hemophilia, indicating that these patients lacked a factor different from those involved in hemophilia. (medscape.com)
  • [ 1 ] This disorder was found in both sexes and was understood to be inherited but was identified as being a less severe abnormality than that observed with hemophilia A and B. Hence, older terms for this disorder included Rosenthal syndrome, PTA deficiency, and hemophilia C. (medscape.com)
  • Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C (see image below). (medscape.com)
  • BACKGROUND Factor XI deficiency, also known as hemophilia C, is a rare inherited bleeding disorder that may leave routine coagulation parameters within normal range. (uniroma1.it)
  • [ 10 ] which, though significant, are not as severe as those seen in hemophilia A or hemophilia B . This finding reflects the important role factor XI plays in hemostasis. (medscape.com)
  • Coagulation disorders include Hemophilia A and B (which are inherited disorders), and Hemophilia C (which is due to a deficiency of factor XI). (differencebetween.net)
  • Hemophilia Hemophilias are common hereditary bleeding disorders caused by deficiencies of either clotting factor VIII or IX. (msdmanuals.com)
  • Factor XI deficiency Most hereditary coagulation disorders other than hemophilia are rare autosomal recessive conditions that cause excessive bleeding only in people homozygous for the recessive gene mutation. (msdmanuals.com)
  • 1. Menegatti M, Peyvandi F . Treatment of rare factor deficiencies other than hemophilia. (msdmanuals.com)
  • Somewhere between the prep and the injection we all realized history was being made: this was the first - repeat, the FIRST - Tanzanian with hemophilia ever to get an infusion of factor VIII within Tanzania. (kelleycom.com)
  • The X-linked hereditary bleeding lifelong disorder known as hemophilia (in which the blood does not clot properly) is characterised by factor VIII (hemophilia A) or factor IX (hemophilia B or Christmas disease) deficiency. (novumprs.com)
  • Acquired hemophilia is a variety of the condition that occurs when a person's immune system attacks clotting factor VIII or IX in the blood. (novumprs.com)
  • Depending on your level of clotting factors, hemophilia can manifest itself in a variety of ways. (novumprs.com)
  • Bispecific antibody therapy (hemophilia A only).Emicizumab (Hemlibra) is a newer drug that doesn't include clotting factors. (novumprs.com)
  • This hormone may encourage the body to release more clotting factor in some mild hemophilia types. (novumprs.com)
  • A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia. (nih.gov)
  • 26 May 2018 Factor XI Deficiency is a genetically inherited disease that's a form of hemophilia. (firebaseapp.com)
  • Recombinant factor VIIa (rFVIIa) has become available for treating people with hemophilia with inhibitors who experience bleeding or require surgery. (medscape.com)
  • Originally, rFVIIa was developed for the treatment of bleeding complications in patients with hemophilia with alloantibodies (inhibitors) against exogenous factor VIII or IX. (medscape.com)
  • We describe the uses of rFVIIa in conditions unrelated to hemophilia and the treatment of acquired inhibitors of factors VIII and IX. (medscape.com)
  • In hemophilia A, the missing substance is factor VIII. (en-academic.com)
  • Hemophilia B - Hemophilia due to deficiency of coagulation factor IX in the blood which results in prolonged oozing after minor and major injuries, tooth extractions, or surgery. (en-academic.com)
  • BACKGROUND: Hemophilia B (HB) is a bleeding disorder characterized by coagulation factor (F) IX (FIX) deficiency. (bvsalud.org)
  • Extended half-life recombinant FIX (rFIX) molecules have been generated to reduce the dosing burden and increase the protection of patients with hemophilia B. Clinical pharmacology studies with recombinant factor IX Fc fusion protein (rFIXFc) report a similar initial peak plasma recovery to that of rFIX, but with a larger volume of distribution. (bvsalud.org)
  • Orphanet : 329] The disease is also called plasma thromboplastin antecedent (PTA) deficiency, haemophilia C, or Rosenthal syndrome. (omia.org)
  • Join us to meet others with haemophilia, von Willebrand disorder (VWD), factor XI deficiency, Glanzmann Thrombasthenia and other rare genetic bleeding disorders. (haemophilia.org.uk)
  • Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, present in about 1 in 5,000-10,000 male births. (rarediseaseday.org)
  • 2] Haemophilia B (factor IX deficiency) occurs in around 1 in about 20,000-34,000 male births. (rarediseaseday.org)
  • Although it is not impossible for a female to have haemophilia, it is unusual: a female with haemophilia A or B would have to be the daughter of both a male haemophiliac and a female carrier, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent[3] but rare in other population groups. (rarediseaseday.org)
  • Haemophilia patients have lower clotting factor level of blood plasma or impaired activity of the coagulation factors needed for a normal clotting process. (rarediseaseday.org)
  • Prof. Hermans discusses the differences between clotting factor VIII and factor IX deficiencies in female carriers of haemophilia, referred to as women and girls with haemophilia, and their underlying mechanisms. (roche.com)
  • Haemophilia A and B are both rare X-linked, hereditary bleeding disorders, caused by mutations in the genes encoding clotting factor VIII and factor IX, respectively, with the varying disease severity classified according to the level of factor activity. (roche.com)
  • TT virus contaminates first-generation recombinant factor VIII concentrates. (medscape.com)
  • Results: Non-bleeders and bleeders had similarly low FXI levels, normal prothrombin times, normal levels of fibrinogen, factor VIII, von Willebrand factor and factor XIII, and normal platelet number and function. (tau.ac.il)
  • Antithrombin lowers the level of activated factor X. In addition, protein C and S and also responsible to stop over-clotting and do so by preventing the activation of factor V and VIII. (differencebetween.net)
  • When protein C and S deficiencies are present, disorders that lead to over clotting can occur and leave the body in a state where it is unable to stop factor V and VIII. (differencebetween.net)
  • This increase in the thrombin burst occurs after direct rFVIIa activation of factors IX and X on the surface of activated platelets (even in the absence of factor VIII or IX). (medscape.com)
  • Prof. Tiede discusses the history of discrepancies between assays of clotting factor VIII activity, including the introduction of recombinant concentrates, and provides an overview of the mechanisms for these discrepancies. (roche.com)
  • There are many things other than genetic variants that can contribute to the development of these diseases or conditions, including environmental or lifestyle factors. (latimes.com)
  • All data to date have been consistent with the hypothesis that hereditary factor XI deficiency represents a genetic disorder resulting from the absence of factor XI molecule. (ashpublications.org)
  • Employing data related to genetic variants that alter factor XI levels, the investigators found that in these individuals, the odds ratios (ORs) for venous thrombosis and ischemic stroke were 0.1 and 0.47, respectively, with the OR for major bleeding being 0.7. (medscape.com)
  • Impact of genetic structural variants in factor XI deficiency: identification, accurate characterization, and inferred mechanism by long-read sequencing. (nih.gov)
  • Many conditions need both genetic and environmental or lifestyle factors to develop. (medicalnewstoday.com)
  • This correlates with epidemiologic data suggesting that patients with a genetic factor XI deficiency have low rates of stroke and MI but don't appear to bleed spontaneously, Patel notes. (medscape.com)
  • Factor V Leiden is a disorder caused by a genetic mutation which results in a defect of factor V to the extent that protein C is unable to activate is. (differencebetween.net)
  • Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)
  • A large variety of factors exist that influence disease progression, including social and behavioral factors, systemic factors, genetic factors, tooth factors and microbial composition of the dental biofilm. (bvsalud.org)
  • Rosenthal and colleagues first described factor XI deficiency in 1953. (medscape.com)
  • Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. (nih.gov)
  • Factor XI (FXI) deficiency is a rare autosomal disorder that may be associated with bleeding. (medscape.com)
  • FXI deficiency can manifest first as a bleeding disorder or as an incidental laboratory abnormality. (medscape.com)
  • Factor XI (FXI) deficiency is an autosomal bleeding disorder, usually posttrauma or postsurgery, characterized by reduced levels of coagulation FXI in plasma. (hunimed.eu)
  • An hereditary deficiency in Factor XI can result in a lifelong bleeding disorder or go undetected. (medicalalgorithms.com)
  • 1a) A patient with a minor factor deficiency may have a minor bleeding disorder. (medicalalgorithms.com)
  • Congenital factor XI deficiency / F11 deficiency is an inherited bleeding disorder characterized by reduced levels and activity of factor XI (FXI) resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. (omia.org)
  • Background: Factor XI (FXI) deficiency is a rare autosomal recessive disorder. (tau.ac.il)
  • 2011-08-16 · Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. (firebaseapp.com)
  • Factor XIII deficiency is a congenital disorder that is inherited as an autosomal recessive trait and is associated with a variable bleeding tendency Acquired factor XIII deficiency is associated with liver failure, inflammatory bowel disease, leukemia, disseminated intravascular coagulation, Henoch-Schonlein purpura, systemic lupus erythematosus and exposure to certain drugs (phenytoin People with congenital (or inherited) factor XIII deficiency are born with low levels of factor XIII in the blood. (firebaseapp.com)
  • Factor XIII deficiency is a rare bleeding disorder. (firebaseapp.com)
  • Hereditary bleeding disorder caused by deficiency of a coagulation factor. (en-academic.com)
  • hereditary bleeding disorder caused by a deficiency of a substance necessary for blood clotting ( coagulation ). (en-academic.com)
  • This results in no measurable FXI in the homozygous state and a measurable factor XI level that is lower than the expected 50% in the heterozygous state. (medscape.com)
  • The antiserum was used in a neutralization-inhibition assay to study the relation between factor XI clotting activity and factor XI antigen in plasma from ten unrelated patients with homozygous factor XI deficiency and from 12 heterozygous family members of these patients. (ashpublications.org)
  • A 78-year-old man with homozygous factor XI deficiency and an extensive medical history, including coronary artery disease, congestive heart failure, diabetes, and chronic kidney disease, was admitted in April 2017 for transurethral resection of the bladder as the result of a urologic malignancy. (cdc.gov)
  • Todd T, J Perry D. A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies. (medscape.com)
  • A family with hereditary FⅪ deficiency caused by compound heterozygous mutation]. (nih.gov)
  • The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)
  • FXI deficiency can manifest as an incidental laboratory abnormality-for example, when a preoperative workup for elective surgery reveals an unexpected prolongation of the activated partial thromboplastin time (aPTT). (medscape.com)
  • [ 3 ] They identified the abnormality as a deficiency in a clotting factor, which they termed plasma thromboplastin antecedent (PTA). (medscape.com)
  • He identified the abnormality as a factor deficiency, which he termed PTA, that was distinct from the already identified antihemophilic globulin. (medscape.com)
  • Like many other coagulation factors, it is a serine protease. (wikipedia.org)
  • Recent findings from our group and others demonstrate the involvement of coagulation factors in both atherosclerosis ( 27 , 28 ) and AD ( 29 , 30 ). (spandidos-publications.com)
  • Thus when a blood vessel is injured, a temporary scab does form, but the missing coagulation factors prevent fibrin formation, which is necessary to maintain the blood clot. (rarediseaseday.org)
  • Unmet needs remain regarding the development of non-invasive administration routes for coagulation factors. (bvsalud.org)
  • FXI is a zymogen, and when activated by factor XIIa or thrombin or when it is autoactivated, FXI becomes a trypsinlike serine protease. (medscape.com)
  • Polyphosphate is a cofactor for the activation of factor XI by thrombin. (medscape.com)
  • Rugeri L, Quélin F, Chatard B, De Mazancourt P, Negrier C, Dargaud Y. Thrombin generation in patients with factor XI deficiency and clinical bleeding risk. (medscape.com)
  • One contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and glycoprotein Ib and the fourth is implicated in forming the factor XI homodimer, including a cysteine residue that creates a disulfide bond. (wikipedia.org)
  • Activation by thrombin or factor XIIa is achieved by cleavage of Arg369-Ile370 peptide bonds on both subunits of the dimer. (wikipedia.org)
  • [ 1 ] Factor XI enhances generation of thrombin at the platelet surface. (medscape.com)
  • Activation of factor XIII (FXIII) by thrombin and calcium is a 2-step process. (medscape.com)
  • Factor XIII Deficiency Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. (firebaseapp.com)
  • The decrease in fibrinolysis might be due to an increase in thrombin-activatable fibrinolysis inhibitor and an increase in factor XIIIa. (medscape.com)
  • rFVIIa is able to activate factor X on phospholipid vesicles, activated platelets, or monocytes independent of TF, although the TF-independent generation of thrombin is much less efficient than the TF-dependent thrombin generation by rFVIIa. (medscape.com)
  • Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency. (medscape.com)
  • A common ancestral mutation (C128X) occurring in 11 non-Jewish families from the UK with factor XI deficiency. (medscape.com)
  • This third group is thought to explain the dominant mutation patterns that are seen in some families with FXI deficiency. (medscape.com)
  • Pharmacological inhibitors of factor XI that are under clinical development but not yet approved for treatment as of May 2022[update] include the oral factor XIa inhibitors Asundexian (BAY 2433334) and Milvexian as well as the monoclonal anti-factor XI antibody Abelacimab (MAA868). (wikipedia.org)
  • 2022-01-11. (epfl.ch)
  • Activated factor XI can be inactivated by antithrombin III, alpha1-protease inhibitor, C1 inhibitor, and alpha2-antiplasmin. (medscape.com)
  • Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI, a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its action on factor X, however, is protein Z-dependent, hence its name). (wikipedia.org)
  • This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. (mcmaster.ca)
  • Topline results from the largest study so far of a factor XI inhibitor ― released last week ― are indeed very encouraging. (medscape.com)
  • The phase 2 AZALEA-TIMI 71 study was stopped early because of an "overwhelming" reduction in major and clinically relevant nonmajor bleeding shown with the factor XI inhibitor abelacimab (Anthos) compared to rivaroxaban for patients with atrial fibrillation (AF). (medscape.com)
  • Severe deficiency of alpha 2-antiplasmin (levels 1 to 3% of normal), the major physiologic inhibitor of plasmin, can also cause bleeding as a result of poor control of plasmin-mediated proteolysis of fibrin polymers. (msdmanuals.com)
  • Affected dogs have significantly decreased Factor XI activity levels (less than 10%), heterozygous/carrier dogs have decreased Factor XI activity levels, (25-50%) but appear to be asymptomatic (Fogh and Fogh, 1988). (omia.org)
  • Congenital Factor XI deficiency is characterised by abnormal haemostasis and excessive bleeding, usually following trauma or surgery. (omia.org)
  • Inbal A, Oldenburg J, Carcao M, Rosholm A, Tehranchi R, Nugent D. Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency. (medscape.com)
  • New developments in the management of congenital Factor XIII deficiency. (medscape.com)
  • Congenital factor XIII deficiency is very rare, affecting only 1 in 2 million people - about 100-125 people in the US. (firebaseapp.com)
  • Low levels of factor XI also occur in many other disease states, including Noonan syndrome. (wikipedia.org)
  • New information cerebellar abiotrophy of Arabians, Severe Combined Immunodeficieincy (SCID) of Arabians, Lavender foal syndrome of Arabians, Lethal White Syndrome of overo Paints, Glycogen Branching Enzyme Deficiency (GBED) of Quarter Horses, hemophila and thrombobasthenia will be discussed. (dvm360.com)
  • Options include factor replacement with fresh frozen plasma, antifibrinolytic therapy with tranexamic acid, and fibrin glue. (medscape.com)
  • FXI deficiency can result from mutations that impair either the synthesis of the FXI molecule or the secretion of the FXI molecule from the producing cell. (medscape.com)
  • Two predominant mutations, type II and III (using an older classification system) cause the FXI deficiency in patients of Ashkenazi Jewish descent. (medscape.com)
  • Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
  • Therefore, identifying mutations in F10 is important for diagnosing congenital FX deficiency. (karger.com)
  • Biological determinants of bleeding in patients with heterozygous factor XI deficiency. (medscape.com)
  • Castaman G, Ruggeri M, Rodeghiero F. Clinical usefulness of desmopressin for prevention of surgical bleeding in patients with symptomatic heterozygous factor XI deficiency. (medscape.com)
  • The administration of 4-factor prothrombin complex concentrate (4F-PCC) has expanded beyond its Food and Drug Administration (FDA)-approved indication for the emergent reversal of vitamin K antagonists (VKAs). (bvsalud.org)
  • BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. (lu.se)
  • METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in the PROC (protein C), PROS1 (protein S), and SERPINC1 (antithrombin) anticoagulant genes were determined in 29 387 subjects (born 1923-1950, 60% women) who participated in the Malmö Diet and Cancer study (1991-1996). (lu.se)
  • Mangla A, Hamad H, Kumar A. Factor XIII Deficiency. (medscape.com)
  • Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management. (medscape.com)
  • Karimi M, Peyvandi F, Naderi M, Shapiro A. Factor XIII deficiency diagnosis: challenges and tools. (medscape.com)
  • Central nervous system bleeding in pediatric patients with factor XIII deficiency: a study on 23 new cases. (medscape.com)
  • Gynecological and obstetric outcome in the French cohort of women with factor XIII deficiency. (medscape.com)
  • Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. (firebaseapp.com)
  • The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. (mcmaster.ca)
  • 143-146 Supplementation with human or recombinant factor XIII has been demonstrated to reduce bleeding after adult heart surgery, although possibly only in the presence of factor deficiency. (firebaseapp.com)
  • This has become the case for treatment of hemorrhage with recombinant factor VIIa (rFVIIa). (medscape.com)
  • A proposed classification system for factor XI deficiency is based on the patterns of protein production or dimerization of the FXI molecule. (medscape.com)
  • The unknown functions of a known protein: the case of coagulation factor XI. (nih.gov)
  • Type I deficiency is a quantitative defect resulting from decreased synthesis of the protein, whereas type II deficiency is characterized by a normal or near‐normal concentration of functionally defective FXIII‐A. Untreated, severe congenital FXIII‐A deficiency causes severe bleeding events in the majority of cases, with intracranial hemorrhage being the major cause of death. (firebaseapp.com)
  • Factor XI deficiency acquired by liver transplantation. (medscape.com)
  • Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form. (wikipedia.org)
  • Factor XI is synthesized in the liver and megakaryocytes and is an 80-kd zymogen precursor of a serine protease. (medscape.com)
  • Acquired factor XIII (FXIII) deficiency can be caused by liver disease, inflammatory bowel disease , and disseminated intravascular coagulation , although controversy surrounds whether the low plasma levels in these conditions actually contribute to clinical bleeding. (medscape.com)
  • The presence or absence of some of these variants is associated with an increased risk for developing any one of the following diseases or conditions: Parkinson's disease, late-onset Alzheimer's disease, celiac disease, alpha-1 antitrypsin deficiency, early-onset primary dystonia, factor XI deficiency, Gaucher disease type 1, glucose-6-phosphate dehydrogenase deficiency, hereditary hemochromatosis, and hereditary thrombophilia. (aacc.org)
  • In humans, Factor XI is encoded by the F11 gene. (wikipedia.org)
  • The gene for factor XI is located on chromosome 4. (medscape.com)
  • In mice, knockout of the gene for factor XI does not lead to death in utero. (medscape.com)
  • This gene encodes coagulation factor XI of the blood coagulation cascade. (nih.gov)
  • Bleeding typically occurs after trauma or surgery in people who are homozygotes or compound heterozygotes for factor XI gene abnormalities. (msdmanuals.com)
  • Severity of bleeding in factor XI deficiency could not be correlated with the level of factor XI activity or factor XI antigen. (ashpublications.org)
  • The extent of factor deficiency determines the probability and severity of bleeding. (msdmanuals.com)
  • In patients with a deficiency of factor XI, there is no clear association between factor XI plasma levels and the severity of bleeding, indicating that the molecular action of factor XI in normal hemostasis is not precisely understood. (msdmanuals.com)
  • There is no precise relationship between the plasma factor XI level and severity of bleeding. (msdmanuals.com)
  • The so-called contact factors include factor XI, factor XII, high-molecular-weight kininogen (HK), and prekallikrein (PK). (medscape.com)
  • 4) The assay for Factor XI may be falsely elevated if the blood sample is exposed to glass or if it has been frozen (false negative). (medicalalgorithms.com)
  • It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay. (mcmaster.ca)
  • He also discusses the significance and relevance of assay discrepancies in contemporary factor concentrates, including longer-acting molecules and provide guidance for practical solutions within clinical laboratories. (roche.com)
  • Definition of the bleeding tendency in factor XI-deficient kindreds--a clinical and laboratory study. (medscape.com)
  • The pharmaceutical industry is on the case with several factor XI inhibitors now in clinical development. (medscape.com)
  • Dickneite G, Herwald H, Korte W, Allanore Y, Denton CP, Matucci Cerinic M. Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions. (medscape.com)
  • FXI remains on the surface and activates factor IX in plasma. (medscape.com)
  • Plasma is the fluid compartment of blood containing the soluble clotting factors. (medscape.com)
  • Dental surgery in patients with severe factor XI deficiency without plasma replacement. (medscape.com)
  • Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. (wikipedia.org)
  • This antiserum, after concentration, neutralized 50% of the factor XI clotting activity of a standard normal plasma at an antiserum dilution of 1/900. (ashpublications.org)
  • Binding of factor XIa to activated platelets localizes it to the site of clot formation and protects it from plasma protease inhibitors. (medscape.com)
  • During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. (nih.gov)
  • This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. (nih.gov)
  • The patient also received 14 plasma transfusions to keep his factor XI levels above the hemostatic threshold. (cdc.gov)
  • Use of desmopressin for prophylaxis of surgical bleeding in factor XI- deficient patients. (medscape.com)
  • A study by Kyrle et al reported that in patients who had experienced an unprovoked venous thromboembolism (VTE), the 10-year probability of VTE recurrence was 31% in individuals below the 34th percentile for factor XIa, compared with 43% for those between the 34th and 67th percentiles, and 41% for patients in a higher percentile. (medscape.com)
  • Moreover, the results indicated that among patients with lower factor XI levels, the absolute risk reductions are greater in individuals at high risk for thrombosis, including those with atrial fibrillation or cancer. (medscape.com)
  • Phenotype and genotype analysis of patients with severe factor XI deficiency in Shaanxi Province, China. (nih.gov)
  • Naderi M, Eshghi P, Cohan N, Miri-Moghaddam E, Yaghmaee M, Karimi M. Successful delivery in patients with FXIII deficiency receiving prophylaxis: report of 17 cases in Iran. (medscape.com)
  • Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
  • The expanded use of 4F-PCC was associated with a less robust reduction in the international normalized ratio (INR) (INR of -0.7 ± 1.3 vs INR of -1.6 ± 1.8, P = .002), and fewer patients in the nVKA group achieved a postadministration INR of less than1.5 (11% vs 79%, P = .001) than those in the VKA group. (bvsalud.org)
  • Menstrual bleeding, pregnancy and delivery present an intrinsic haemostatic challenge to women with bleeding disorders such as factor XI (FXI) deficiency. (rug.nl)
  • High levels of factor XI have been implicated in thrombosis, although it is uncertain what determines these levels and how serious the procoagulant state is. (wikipedia.org)
  • [ 7 ] In a mouse model, factor XI appears to play a greater role in thrombosis than in hemostasis. (medscape.com)
  • On the other hand, a study by Georgi et al indicated that in persons genetically disposed to lower concentrations of factor XI, the risk of venous thrombosis and ischemic stroke are reduced. (medscape.com)
  • The authors suggested that the risk of venous thrombosis and ischemic stroke may be significantly reduced by pharmacologic inhibition of factor XI, with no clear evidence demonstrating that this therapy would increase the risk for major bleeding. (medscape.com)
  • The hope that factor XI inhibitors will prevent pathologic thrombosis with a lower bleeding risk compared to other anticoagulants comes down to the role of factor XI in the coagulation cascade. (medscape.com)
  • Another doctor involved in the field, Manesh Patel, MD, chief of cardiology at Duke University Medical Center, added, "We think that factor XI inhibitors may prevent the pathologic formation of thrombosis while allowing formation of thrombus for natural hemostasis to prevent bleeding. (medscape.com)
  • It can be activated in vitro by activated factor XII (XIIa). (medscape.com)
  • Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bbb complex (C3 convertase) and the (C3b)nbb complex (C5 convertase) in the alternative complement pathway. (lu.se)
  • This report summarizes two new recommendations approved by ACIP: 1) routine vaccination of adolescents, preferably at age 11 or 12 years, with a booster dose at age 16 years and 2) a 2-dose primary series administered 2 months apart for persons aged 2 through 54 years with persistent complement component deficiency (e.g. (cdc.gov)
  • Asakai R, Chung DW, Davie EW, Seligsohn U. Factor XI deficiency in Ashkenazi Jews in Israel. (medscape.com)
  • 11. Why don't they tell the truth, that Vitamin D deficiency is a major risk factor for serious illness? (blogspot.com)
  • Vitamin B12 deficiency: a factor that induces depression? (bvsalud.org)
  • The deficiency of vitamin B12 creates a case of hyperhomocysteinemia and decline of S-adenosylmethionine, which is a risk factor for depression without adequate treatment. (bvsalud.org)
  • This project had as an objective to verify the relation between depression and the deficiency of vitamin B12, through literary revision. (bvsalud.org)
  • Bleeding associated with FXI deficiency is predictable neither within a patient nor within a family. (medscape.com)
  • In contrast to hemophilias A and B, bleeding manifestations in FXI deficiency often show little correlation with the FXI level. (medscape.com)
  • Aim: To provide a systematic overview of studies on gynaecological and obstetrical bleeding problems in women with FXI deficiency. (rug.nl)
  • Conclusion: Women with FXI deficiency have a clearly increased risk of HMB, and of bleeding complications after miscarriage, TOP and delivery. (rug.nl)
  • 1) An affected patient may show a variable bleeding tendency that depends on the level of Factor XI present. (medicalalgorithms.com)
  • 1b) A patient with a major factor deficiency may experience excessive bleeding. (medicalalgorithms.com)
  • 3) The bleeding may be worse after aspirin or if other coagulation deficiencies are present. (medicalalgorithms.com)
  • Marked decreases in factor XI are indicative of a mild bleeding diathesis. (medscape.com)
  • The problem, therefore, with anticoagulants used to date that block one of these factors is that they prevent clotting but also cause bleeding. (medscape.com)
  • By repeatedly triggering bleeding into muscles and joints, deficiency produces hemophilic arthropathy and contractures. (novumprs.com)
  • The management of bleeding episodes includes infusions of clotting factor, which is derived from human blood or by recombinant DNA technology. (en-academic.com)
  • Severe deficiency can present with catastrophic bleeding in infancy. (roche.com)