Factor XII Deficiency
Factor XII
Alzheimer's beta-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent manner. (1/39)
beta-Amyloid (beta-A) accumulates in the brain of patients with Alzheimer's disease (AD) and is presumably involved in the pathogenesis of this disease, on account of its neurotoxicity and complement-activating ability. Although assembly of beta-A in particular aggregates seems to be crucial, soluble non-fibrillar beta-A may also be involved. Non-fibrillar beta-A does not bind C1q, so we investigated alternative mechanisms of beta-A-dependent complement activation in vitro. On incubation with normal human plasma, non-fibrillar beta-A 1-42, and truncated peptide 1-28, induced dose-dependent activation of C1s and C4, sparing C3, as assessed by densitometric analysis of immunostained membrane after SDS-PAGE and Western blotting. The mechanism of C4 activation was not dependent on C1q, because non-fibrillar beta-A can still activate C1s and C4 in plasma genetically deficient in C1q (C1qd). In Factor XII-deficient plasma (F.XIId) the amount of cleaved C4 was about 5-10% less that in C1qd and in normal EDTA plasma; the reconstitution of F.XIId plasma with physiologic concentrations of F.XII resulted in an increased (8-15%) beta-A-dependent cleavage of C4. Thus our results indicate that the C1q-independent activation of C1 and C4 can be partially mediated by the activation products of contact system. Since the activation of contact system and of C4 leads to generation of several humoral inflammatory peptides, non-fibrillar beta-A might play a role in initiating the early inflammatory reactions leading to a multistep cascade contributing to neuronal and clinical dysfunction of AD brain. (+info)Factor XII Tenri, a novel cross-reacting material negative factor XII deficiency, occurs through a proteasome-mediated degradation. (2/39)
A homozygous cross-reacting material negative factor XII-deficient patient with 3% antigen and activity levels of factor XII was screened for the identification of a mutation at the genomic level. Low-ionic strength single-stranded conformation polymorphism (SSCP) analysis and sequence analysis showed that the proband's gene for factor XII had an A-->G substitution at nucleotide position 7832 in exon 3, resulting in a Tyr34 to Cys substitution in the NH2-terminal type II domain of factor XII. We designated this mutation as factor XII Tenri. Mutagenic polymerase chain reaction (PCR), followed by KpnI digestion, showed a homozygous mutation in the proband's gene and heterozygous mutations in his parents and sister. Immunoprecipitation and Western blot analyses of plasma samples from the factor XII Tenri family indicated that the proband had a trace amount of variant factor XII with an apparent molecular mass of 115 kD, which was converted to the normal 80-kD form after reduction, suggesting that factor XII Tenri was secreted as a disulfide-linked heterodimer with a approximately 35-kD protein, which we identified as alpha1-microglobulin by immunoblotting. Pulse-chase experiments using baby hamster kidney (BHK) cells showed that Tenri-type factor XII was extensively degraded intracellularly, but the addition of cystine resulted in increased secretion of the mutant. Using membrane-permeable inhibitors, we observed that the degradation occurred in the pre-Golgi, nonlysosomal compartment and a proteasome appeared to play a major role in this process. On the basis of these in vitro results, we speculate that the majority of the factor XII Tenri is degraded intracellularly through a quality control mechanism in the endoplasmic reticulum (ER), and a small amount of factor XII Tenri that formed a disulfide-linked heterodimer with alpha1-microglobulin is secreted into the blood stream. (+info)A modified, optimized kinetic photometric assay for the determination of blood coagulation factor XIII activity in plasma. (3/39)
BACKGROUND: Blood coagulation factor XIII (FXIII) is a zymogen that is transformed into an active transglutaminase by thrombin and Ca(2+). FXIII plays an essential role in fibrin stabilization and in the protection of fibrin from proteolytic degradation. No convenient method has been available for the measurement of FXIII activity in plasma. The aim of the present study was to improve and optimize a kinetic photometric FXIII assay originally developed in our laboratory. METHODS: In the assay, FXIII was activated by thrombin and Ca(2+). Fibrin polymerization was prevented by an inhibitory tetrapeptide. Glycine-ethyl ester and a glutamine residue of a synthetic dodecapeptide served as acyl acceptor and acyl donor transglutaminase substrates, respectively. The amount of ammonia released during the reaction was monitored using glutamate dehydrogenase and NADPH. RESULTS: The use of a new glutamine substrate and optimization of activator and substrate concentrations increased sensitivity. Substitution of NADPH for NADH and introduction of an appropriate blank eliminated systemic overestimation of FXIII activity. The recovery of FXIII was 96%, the assay was linear up to 470 U/L, the detection limit was 1 U/L, and the imprecision (CV) was <8% even at very low FXIII activities. A reference interval of 108-224 U/L (69-143%) was established. The results correlated well with results obtained by an immunoassay specific for plasma FXIII. CONCLUSIONS: The optimized FXIII assay is a simple, rapid method for the diagnosis of inherited or acquired FXIII deficiencies and increased FXIII concentrations. It can be easily adapted to clinical chemistry analyzers. (+info)Defective thrombus formation in mice lacking coagulation factor XII. (4/39)
Blood coagulation is thought to be initiated by plasma protease factor VIIa in complex with the membrane protein tissue factor. In contrast, coagulation factor XII (FXII)-mediated fibrin formation is not believed to play an important role for coagulation in vivo. We used FXII-deficient mice to study the contributions of FXII to thrombus formation in vivo. Intravital fluorescence microscopy and blood flow measurements in three distinct arterial beds revealed a severe defect in the formation and stabilization of platelet-rich occlusive thrombi. Although FXII-deficient mice do not experience spontaneous or excessive injury-related bleeding, they are protected against collagen- and epinephrine-induced thromboembolism. Infusion of human FXII into FXII-null mice restored injury-induced thrombus formation. These unexpected findings change the long-standing concept that the FXII-induced intrinsic coagulation pathway is not important for clotting in vivo. The results establish FXII as essential for thrombus formation, and identify FXII as a novel target for antithrombotic therapy. (+info)Subdural hematoma in a patient with Hageman trait--case report. (5/39)
A 61-year-old man with severe factor XII deficiency presented with a subdural hematoma appearing as mixed but mainly high density by computed tomography in the left frontotemporoparietal region. No cranial injury was reported in the medical history of the patient. Clotting system study showed less than 1% functional activity of factor XII, whereas the levels of the other clotting factors were within the normal ranges. Partially clotted and hemolyzed subdural hematoma was removed through a craniotomy. The postoperative course was uneventful. The patient later died of severe circulatory-respiratory failure. We believe that the subdural hematoma may have developed as a result of a minor head trauma sustained in the past. We suggest that impairment of fibrinolytic activation related to severe factor XII deficiency might have contributed to the delay of dissolution of the subdural hematoma which, under ordinary circumstances, would have formed chronic subdural hematoma. (+info)Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. (6/39)
Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis), but may also contribute to vascular thrombosis. Hereditary deficiency of factor XII (FXII), the protease that triggers the intrinsic pathway of coagulation in vitro, is not associated with spontaneous or excessive injury-related bleeding, indicating FXII is not required for hemostasis. We demonstrate that deficiency or inhibition of FXII protects mice from ischemic brain injury. After transient middle cerebral artery occlusion, the volume of infarcted brain in FXII-deficient and FXII inhibitor-treated mice was substantially less than in wild-type controls, without an increase in infarct-associated hemorrhage. Targeting FXII reduced fibrin formation in ischemic vessels, and reconstitution of FXII-deficient mice with human FXII restored fibrin deposition. Mice deficient in the FXII substrate factor XI were similarly protected from vessel-occluding fibrin formation, suggesting that FXII contributes to pathologic clotting through the intrinsic pathway. These data demonstrate that some processes involved in pathologic thrombus formation are distinct from those required for normal hemostasis. As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases. (+info)Are hemostasis and thrombosis two sides of the same coin? (7/39)
Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo because hereditary deficiencies in FXII are not associated with spontaneous or excessive bleeding. However, new studies show that mice lacking FXII are protected against arterial thrombosis (obstructive clot formation) and stroke. Thus, FXII could be a unique drug target that could be blocked to prevent thrombosis without the side effect of increased bleeding. (+info)Factor XII deficiency acquired by orthotopic liver transplantation: case report and review of the literature. (8/39)
Transmission of congenital clotting factor deficiencies after orthotopic liver transplantation is rare. There are published reports of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia, protein S, factor VII and factor XI deficiencies. We report a case of transmission of factor XII deficiency with liver transplantation in a patient with Budd-Chiari syndrome. There was a persistent elevation of the activated partial thromboplastin time (aPTT), but no evidence of bleeding while the patient was maintained on warfarin. The presence of a persistently abnormal aPTT may raise suspicion for the presence of a clotting factor deficiency; however, deficiencies of other clotting factors may not be readily apparent on routine blood tests performed in a donor. Being aware of the possibilities of transmission of these inherited deficiencies of coagulation factors will aid in their early detection and management in the transplant donor and recipient. (+info)Factor XII deficiency, also known as Hageman factor deficiency, is a rare genetic disorder characterized by a lack or dysfunction of coagulation factor XII. This protein is involved in the initiation of the coagulation cascade, which leads to the formation of a blood clot. People with Factor XII deficiency may have an increased risk of bleeding, but it is typically mild and not life-threatening. The diagnosis is usually made through blood tests that measure the level and function of Factor XII. Treatment is generally not necessary unless there is significant bleeding, in which case fresh frozen plasma or cryoprecipitate may be given to provide temporary correction of the deficiency. It's important to note that Factor XII deficiency is not a common cause of bleeding disorders and it doesn't increase the risk of thrombosis.
Factor XII, also known as Hageman factor, is a protein that plays a role in the coagulation cascade, which is the series of events that leads to the formation of a blood clot. It is one of the zymogens, or inactive precursor proteins, that becomes activated and helps to trigger the coagulation process.
When Factor XII comes into contact with negatively charged surfaces, such as damaged endothelial cells or artificial surfaces like those found on medical devices, it undergoes a conformational change and becomes activated. Activated Factor XII then activates other proteins in the coagulation cascade, including Factor XI, which ultimately leads to the formation of a fibrin clot.
Deficiencies in Factor XII are generally not associated with bleeding disorders, as the coagulation cascade can still proceed through other pathways. However, excessive activation of Factor XII has been implicated in certain thrombotic disorders, such as deep vein thrombosis and disseminated intravascular coagulation (DIC).
Factor XII deficiency
Metformin
Factor XII
Hypoprothrombinemia
Noonan syndrome
Superficial vein thrombosis
Factor XIII deficiency
Haemophilia C
Iodine deficiency
Partial thromboplastin time
Turoctocog alfa
Achlorhydria
Robert McCarrison
Haemophilia
Plug (accounting)
Eomesodermin
Prekallikrein
Hymenoxys odorata
Damoctocog alfa pegol
Factor VIII
Katherine A. High
Lipoprotein-associated phospholipase A2
Vitamin B12 deficiency
Von Willebrand factor
Factor XI
Quebec platelet disorder
Multimerin 1
Oncogenomics
Severe congenital neutropenia
List of MeSH codes (C16)
Factor XII deficiency - Wikipedia
Factor XII (Hageman factor) deficiency: MedlinePlus Medical Encyclopedia
F12 coagulation factor XII [Homo sapiens (human)] - Gene - NCBI
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Nutritional11
- To conclude, ID is still a public health problem in Morocco highlighting the necessity to implement effective national program, including efficient salt iodization, effective nutritional education and awareness, to control iodine deficiency and prevent IDD development. (who.int)
- However, because of such factors as nutritional deficiencies, underfunded, lower-performing K-12 systems, and the destruction of the social safety net, the disadvantaged category now often includes students with severe cognitive and behavioral problems who come to community colleges because there is nowhere else for them to. (wsws.org)
- [2] Vegans can experience B12 dietary deficiencies, but vegans can look for plant based sources of B12, including nutritional yeast, fortified foods, and B12 supplements. (naturalfactors.com)
- Iron deficiency is the most common known form of nutritional deficiency. (cdc.gov)
- The factors contributing to poor diets are limited financial resources and lack of access to health care and nutritional supplements. (americares.org)
- The medical establishment puts too little credence in underlying nutritional deficiencies that can drive eating disorders, a prominent clinician maintains. (nutraingredients-usa.com)
- environmental as well as nutritional factors playing a role [ 10-12 ]. (who.int)
- 3. In Africa, nutritional problems in infants and young children occur in a context characterized by factors such as the prevalent low birth weight, household food insecurity, inappropriate infant and young child feeding practices, including the absence of food safety and hygiene, and inadequate intake of proteins and energy foods. (who.int)
- 4. Over the past decade, the international community has intensified actions to fight against all these nutritional deficiencies. (who.int)
- Consequently, different nutritional deficiency-related diseases are affecting millions of infants and young children. (who.int)
- In 1998, 16 million deaths were caused by communicable diseases, maternal and perinatal conditions, childhood infections, tobacco-related illness and nutritional deficiencies. (who.int)
20203
- 2020. 12, 3286. (otago.ac.nz)
- The prevalence of chronic energy deficiency in reproductive-aged women will be reduced to 15% by 2010 and less than 12% by 2020. (who.int)
- The prevalence of overweight and obesity in adults will be controlled to a rate of less than 8% by 2010 and will increase to no more than 12% by 2020. (who.int)
Hereditary factor V deficien1
- A novel homozygous mutation (Gly1715Ser) causing hereditary factor V deficiency in a Chinese patient. (medscape.com)
Congenital factor V deficien2
- Mitterstieler G, Muller W, Geir W. Congenital factor V deficiency. (medscape.com)
- Shirzadi M, Radfar AH, Dehghani M. Recurrent miscarriage in a woman with congenital factor V deficiency: a case report. (medscape.com)
Hageman5
- Factor XII, also known as Hageman factor, is indicated when factor XII deficiency is suspected. (medscape.com)
- Coagulation factor XII , also known as Hageman factor , is a plasma protein . (wikidoc.org)
- Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman (1918) was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms. (wikidoc.org)
- Hageman was then examined by hematologist Oscar Ratnoff , who found that Hageman lacked a previously unidentified clotting factor. (wikidoc.org)
- [9] Ratnoff later found that the Hageman factor deficiency is an autosomal recessive disorder, after examining several related people who had the deficiency. (wikidoc.org)
Prevalence4
- This study was planned to evaluate the iodine status and the prevalence of iodine deficiency in a nationally representative sample of Moroccan WRA according to their socio-economic data and living areas. (who.int)
- Rowe S. and Carr A.C. Global vitamin C status and prevalence of deficiency: A cause for concern? (otago.ac.nz)
- Carr A.C. and Rowe S. Factors affecting vitamin C status and prevalence of deficiency: a global health perspective. (otago.ac.nz)
- In the United States, the prevalence of iron-deficiency anemia among children declined during the 1970s in association with increased iron intake during infancy (1-3). (cdc.gov)
Nutrients4
- Different strategies may be needed to control deficiency of these nutrients in different regions of Cameroon. (ihsn.org)
- Clinical deficiencies of nutrients may increase susceptibility to infections. (who.int)
- But even if there is little variation in certain immune factors as claimed, there can be huge variations in other nutrients depending on what the mother eats. (westonaprice.org)
- These data will be used to estimate deficiencies and toxicities of specific nutrients in the population and subgroups, to provide population reference data, and to estimate the contribution of diet, supplements, and other factors to serum levels of nutrients. (cdc.gov)
Micro-nutrient deficiencies2
High-molecular2
- Factor XII, factor XI, high-molecular-weight kininogen (HK), and prekallikrein (PK) are referred to as the contact factors. (medscape.com)
- [6] All of this, including the mechanism of inheritance, also holds true for the other contact factors, prekallikrein (Fletcher factor) and high molecular weight kininogen . (wikidoc.org)
Mutation4
- Delev D, Pavlova A, Heinz S, Seifried E, Oldenburg J. Factor 5 mutation profile in German patients with homozygous and heterozygous factor V deficiency. (medscape.com)
- Asp68His mutation in the A1 domain of human factor V causes impaired secretion and ineffective translocation. (medscape.com)
- Alsheikh S, Alghamdi R, Alqatari A, Alfareed A, AlSaleh M. Combined Factor V and VIII Deficiency with LMAN1 Mutation: A Report of 3 Saudi Siblings. (medscape.com)
- The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)
Activates factor7
- Factor XII deficiency is a deficiency in the production of factor XII (FXII), a plasma glycoprotein and clotting factor that participates in the coagulation cascade and activates factor XI. (wikipedia.org)
- FXI remains on the surface and activates factor IX in plasma. (medscape.com)
- Contact activation involves both protein-protein and protein-surface interactions that activates factor XII. (medscape.com)
- Factor XIIa activates factor XI, which in turn leads to the activation of factor IX. (medscape.com)
- Kallikrein activates factor XII, which, then initiates fibrinolysis by causing activation urokinase. (medscape.com)
- Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. (wikidoc.org)
- Contact to polyphosphates activates factor XII and initiates fibrin formation by the intrinsic pathway of coagulation with critical importance for thrombus formation. (wikidoc.org)
Impaired by vitamin D deficien1
- Firstly, the innate immune system is impaired by vitamin D deficiency, which would predispose sufferers to viral infections such as COVID-19. (frontiersin.org)
Folate deficiency7
- What is folate deficiency anemia? (naturalnews.com)
- Folate deficiency is often caused by not consuming enough foods that contain folate. (naturalnews.com)
- However, even those who eat balanced diets have the potential of developing folate deficiency. (naturalnews.com)
- Folate deficiency is much more common in older people , affecting one in 10 people aged 75 and above. (naturalnews.com)
- However, the symptoms of folate-deficiency anemia may be similar to other blood conditions or health problems. (naturalnews.com)
- People who already have folate-deficiency anemia may need to increase their dietary intake of folic acid , whether it's through their actual diet or supplementation. (naturalnews.com)
- Pregnant women, in particular, should avoid drinking alcohol before and during pregnancy to reduce the risk of folate deficiency. (naturalnews.com)
Folic acid1
- Background: Representative data on folate and vitamin B-12 dietary intake and status in low-income countries are rare, despite the widespread adoption of folic acid fortification. (ihsn.org)
Inherited disorder2
- Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. (medlineplus.gov)
- Factor XII deficiency is a rare inherited disorder. (medlineplus.gov)
Genetic5
- Patients with exogenous immunosuppres- consideration of underlying host genetic factors. (cdc.gov)
- Venous thrombosis is a multifactorial disease frequently related to the interaction of genetic and environmental risk factors. (intechopen.com)
- Some of the recently discovered genetic risk factors, such as factor V Leiden and prothrombin G20210A mutations, are quite common in the population. (intechopen.com)
- Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)
- Numerous genetic, acquired, and environmental factors can tip. (msdmanuals.com)
Disorders7
- FXII deficiency tends to be identified during presurgical laboratory screening for bleeding disorders. (wikipedia.org)
- The condition is of importance in the differential diagnosis to other bleeding disorders, specifically the hemophilias: hemophilia A with a deficiency in factor VIII or antihemophilic globulin, hemophilia B with a deficiency in factor IX (Christmas disease), and hemophilia C with a deficiency in factor XI. (wikipedia.org)
- Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. (medlineplus.gov)
- Etiologically, nonplatelet hemostatic disorders can be divided those involving coagulation factors and those involving vascular aspects of hemostasis. (medscape.com)
- Iodine deficiency disorders (IDD) affects nearly 1.9 million people worldwide. (who.int)
- Most of the congenital coagulation protein disorders reported in domestic animals are deficiencies or abnormalities of a single factor. (msdvetmanual.com)
- Factor II (prothrombin) disorders are rare. (msdvetmanual.com)
Prothrombin1
- Prothrombin time results are impacted by prothrombin protein deficiency. (flebo.in)
Protein4
- Some patients with dysfibrinogenemia have additional hemostasis defects, including factor V Leiden and deficiencies in antithrombin, protein C, and protein S. (medscape.com)
- Type I deficiency is a quantitative defect resulting from decreased synthesis of the protein, whereas type II deficiency is characterized by a normal or near‐normal concentration of functionally defective FXIII‐A. Untreated, severe congenital FXIII‐A deficiency causes severe bleeding events in the majority of cases, with intracranial hemorrhage being the major cause of death. (firebaseapp.com)
- Deficiency of vitamin B-12 occurs due to lack of intrinsic factor, a protein made in the stomach, according to Oregon State University 2 . (healthfully.com)
- Known hereditary thrombophilia (Factor V Leiden, Protein C/ S deficiency, anti-phospholipid or anti-cardiolipin antibodies) k. (who.int)
Abnormal4
- unlike the soft tissue bleeds and hemarthroses that characterize hemophilia A and B, abnormal bleeding in FXI deficiency typically involves mucosal tissues, which are rich in fibrinolytic activity (eg, the oral and nasal cavities and urinary tract). (medscape.com)
- [6] As a result, the main concern related to factor XII deficiency is the unnecessary testing, delay in care, worry, etc. that may be prompted by the abnormal lab result. (wikidoc.org)
- Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
- 2011-08-16 · Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. (firebaseapp.com)
Fibrinogen3
- Afibrinogenemia is defined as a deficiency or absence of fibrinogen (coagulation factor I) in the blood. (medscape.com)
- Acquired fibrinogen deficiency can be associated with several clinical conditions including excessive blood loss in the setting of surgery, trauma or postpartum hemorrhage, hemodilution from from massive transfusion, liver disease, increased consumption in the setting of cancer, DIC or tPA therapy, or assay interference with direct or other thrombin inhibitors. (medscape.com)
- Coagulation factors interact on platelet and endothelial cell surfaces to produce thrombin , which converts fibrinogen to fibrin. (msdmanuals.com)
Leiden1
- Factor V Leiden and Ischemic Stroke Risk: The Genetics of Early Onset Stroke (GEOS) Study. (medscape.com)
Bleeding diathesis2
- Duckers C, Simioni P, Rosing J, Castoldi E. Advances in understanding the bleeding diathesis in factor V deficiency. (medscape.com)
- No bleeding diathesis is associated with its deficiency. (medscape.com)
Platelet2
- Platelet polyphosphate-driven factor XII activation provides the link from primary hemostasis (formation of a platelet plug ) to secondary hemostasis (fibrin meshwork formation). (wikidoc.org)
- Initial platelet adhesion is to long strings of von Willebrand factor (VWF) that have been previously secreted by, and anchored to, stimulated endothelial cells. (msdmanuals.com)
Hemophilia4
- The coagulation defect in plasma from these patients was corrected on mixing with plasma from patients with hemophilia, indicating that these patients lacked a factor different from those involved in hemophilia. (medscape.com)
- [ 1 ] This disorder was found in both sexes and was understood to be inherited but was identified as being a less severe abnormality than that observed with hemophilia A and B. Hence, older terms for this disorder included Rosenthal syndrome, PTA deficiency, and hemophilia C. (medscape.com)
- Factor XII does play an important role in clot formation during in vitro measurements of the partial thromboplastin time , which causes these measurements to be markedly prolonged in patients with factor XII deficiency, usually well beyond even what is seen in hemophilia A, hemophilia B, or factor XI deficiency. (wikidoc.org)
- 26 May 2018 Factor XI Deficiency is a genetically inherited disease that's a form of hemophilia. (firebaseapp.com)
Clinical2
- Since then, case studies and clinical studies identified an association between thrombosis and Factor XII deficiency. (wikidoc.org)
- In a severe deficiency or functional defect of coagulation proteins, clinical signs appear at an early age. (msdvetmanual.com)
Anemia12
- The study aims to quantify bioavailability of iron from NaFeEDTA when added to a wheat flour-based meal in both nonanemic women and women with iron deficiency anemia, when consumed with and without traditional Moroccan green tea. (who.int)
- It concludes that fractional iron absorption from wheat flour-based meals without and with tea was ∼2-fold higher in women with iron deficiency anemia than in nonanemic women. (who.int)
- Providing fortificant iron as NaFeEDTA cannot overcome the inhibition of tea polyphenols on iron absorption, even in iron deficiency anemia, where iron absorption is strongly upregulated. (who.int)
- Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS. (uchicago.edu)
- In the past three decades, increased iron intake among infants has resulted in a decline in childhood iron-deficiency anemia in the United States. (cdc.gov)
- As a consequence, the use of screening tests for anemia has become a less efficient means of detecting iron deficiency in some populations. (cdc.gov)
- These recommendations update the 1989 'CDC Criteria for Anemia in Children and Childbearing-Aged Women' (MMWR 1989;38(22):400-4) and are the first comprehensive CDC recommendations to prevent and control iron deficiency. (cdc.gov)
- Because of this decline, the value of anemia as a predictor of iron deficiency has also declined, thus decreasing the effectiveness of routine anemia screening among children. (cdc.gov)
- CDC requested the Institute of Medicine to convene an expert committee to develop recommendations for preventing, detecting, and treating iron-deficiency anemia among U.S. children and U.S. women of childbearing age. (cdc.gov)
- In addition, 42 percent of infants between 12 and 17 months suffer from anemia, which is caused by iron deficiency. (americares.org)
- Vitamin B-12 deficiency leads to a form of anemia known as pernicious anemia, according to Oregon State University 2 . (healthfully.com)
- Treatment of pernicious anemia involves lifelong vitamin B-12 injections. (healthfully.com)
Prekallikrein1
- Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. (nih.gov)
XIIa6
- This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. (nih.gov)
- On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. (nih.gov)
- The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. (nih.gov)
- FXI is a zymogen, and when activated by factor XIIa or thrombin or when it is autoactivated, FXI becomes a trypsinlike serine protease. (medscape.com)
- It is the zymogen form of factor XIIa, an enzyme ( EC 3.4.21.38 ) of the serine protease (or serine endopeptidase) class. (wikidoc.org)
- Factor XII itself is activated to factor XIIa by negatively charged surfaces, such as glass. (wikidoc.org)
FXII7
- citation needed] While it is indicated that people with FXII deficiency are generally asymptomatic, studies in women with recurrent miscarriages suggest an association with FXII deficiency. (wikipedia.org)
- citation needed] There is concern that individuals with FXII deficiency are more prone to thrombophilic disease, however, this is at variance with a long-term study from Switzerland. (wikipedia.org)
- Inherited or congenital FXII deficiency is usually passed on by autosomal recessive inheritance. (wikipedia.org)
- citation needed] In persons with congenital FXII deficiency the condition is lifelong. (wikipedia.org)
- The acquired form of FXII deficiency is seen in patients with the nephrotic syndrome, liver disease, sepsis and shock, disseminated intravascular coagulation, and other diseases. (wikipedia.org)
- In congenital FXII deficiency treatment is not necessary. (wikipedia.org)
- In acquired FXII deficiency the underlying problem needs to be addressed. (wikipedia.org)
Intrinsic pathway1
- Diagram from the traditional cascade-waterfall model of coagulation shows the place of factor XI in the intrinsic pathway, which leads to the common pathway. (medscape.com)
Zinc deficiency4
- His stunning response to zinc supplementation opened the door to the concept of zinc deficiency and the modern field of research. (nutraingredients-usa.com)
- The people in the US most at risk of zinc deficiency problems tend to be younger and on vegan diets, Dr Greenblatt said. (nutraingredients-usa.com)
- "It can be a subtle factor that pushes them from going on a vegan diet like all their other 12-year-old friends to developing an outright zinc deficiency that interferes with digestion, sleep and body image," Dr Greenblatt said. (nutraingredients-usa.com)
- Zinc deficiency was found in 13 (36.5%) of the cases and 7 (19.4%) of the controls. (who.int)
Fibrin3
- Options include factor replacement with fresh frozen plasma, antifibrinolytic therapy with tranexamic acid, and fibrin glue. (medscape.com)
- Factor XIII(a) crosslinking of fibrin α-chains mediates RBC retention in venous thrombi, and consequently, thrombus size. (zedira.com)
- Factor XIII (FXIII) is a protransglutaminase that, once activated to FXIIIa, crosslinks fibrin and other proteins to the clot. (zedira.com)
Asymptomatic1
- [6] Unlike other clotting factor deficiencies, factor XII deficiency is totally asymptomatic and does not cause excess bleeding. (wikidoc.org)
Autosomal recessive2
- Factor XII deficiency is a rare disorder that is inherited in an autosomal recessive manner. (wikidoc.org)
- Factor XIII deficiency is a congenital disorder that is inherited as an autosomal recessive trait and is associated with a variable bleeding tendency Acquired factor XIII deficiency is associated with liver failure, inflammatory bowel disease, leukemia, disseminated intravascular coagulation, Henoch-Schonlein purpura, systemic lupus erythematosus and exposure to certain drugs (phenytoin People with congenital (or inherited) factor XIII deficiency are born with low levels of factor XIII in the blood. (firebaseapp.com)
Proteins1
- It involves special proteins called coagulation or clotting factors. (medlineplus.gov)
VIII1
- Zheng C, Zhang B. Combined deficiency of coagulation factors V and VIII: an update. (medscape.com)
Heterozygous1
- Since whole blood clots from mice with full or even partial (heterozygous) deficiency of the FXIII catalytic A subunit show similarly increased extrusion of RBCs during clot contraction5, these mice provided an experimental model to investigate the contribution of FXIII to VTE in vivo. (zedira.com)
Hypothesis5
- As the world's attention has been riveted upon the growing COVID-19 pandemic, many researchers have written brief reports supporting the hypothesis that vitamin D deficiency is related to the incidence and severity of COVID-19. (frontiersin.org)
- Two causal modeling studies and several analyses of variance strongly supported the hypothesis that vitamin D deficiency is a causal, rather than a bystander, factor in COVID-19 outcomes. (frontiersin.org)
- Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
- To evaluate the hypothesis that n-3 fatty acid deficiency is a risk factor for CHD morbidity and mortality in MDD, it is important to consider that the age at onset for unipolar and bipolar depression peaks in young adulthood (15-19 years) [ 24 , 25 ], whereas CHD mortality peaks substantially later (75-84 years) [ 26 ]. (hindawi.com)
- "A micronutrient deficiency hypothesis offers a much more robust and comprehensive explanation at the root of these manifestations," he has written. (nutraingredients-usa.com)
Coagulation cascade1
- Factor X plays a central role in the coagulation cascade, and is the first enzyme in the common pathway of thrombus formation [ 1 ]. (mdpi.com)
Hemorrhagic3
- [ 2 ] This is reflected in the fact that individuals who are deficient in any of these factors do not have a hemorrhagic diathesis, even after significant trauma or surgery. (medscape.com)
- No hemorrhagic diathesis is associated with congenital factor XII deficiency. (medscape.com)
- The patient's factor X level recovered after two weeks of discharge with no other hemorrhagic episodes. (mdpi.com)
Anticoagulant2
- The anticoagulant function of coagulation factor V. Thromb Haemost . (medscape.com)
- A mixing study was performed to eliminate the presence of coagulation factor inhibitors and lupus anticoagulant. (karger.com)
Absorption2
- As a result, people could develop a deficiency quickly if they don't eat enough folate-rich foods or they have an underlying condition that affects their absorption. (naturalnews.com)
- A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). (uchicago.edu)
Symptoms6
- To explore the correlations between symptom-based principal factors of rheumatoid arthritis (RA) and the effect of traditional Chinese medicine or Western medicine on RA after factor analysis of RA symptoms. (jcimjournal.com)
- Eighteen symptoms in the RA patients were analyzed by factor analysis and the relationships between the factors and effects were analyzed with Chi-Square test. (jcimjournal.com)
- Four principal factors were obtained from the analysis results of the 18 symptoms. (jcimjournal.com)
- The factors could represent the symptoms related to joints, cold-syndrome, deficiency syndrome and heat-syndrome in traditional Chinese medicine (TCM),respectively. (jcimjournal.com)
- The results based on the factor analysis of RA symptoms are similar to the results of syndrome differentiation of TCM, and the factor-related different categories of symptoms are associated with the curative effect, thus further research on the symptoms is necessary. (jcimjournal.com)
- Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot. (firebaseapp.com)
Iodine1
- Iodine deficiency (ID) remains a public health concern not only for pregnant women, but for women of reproductive age (WRA) as well. (who.int)
Severe2
- Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. (firebaseapp.com)
- Secondly, the groups who are at highest risk for severe COVID-19 match those who are at highest risk for severe vitamin D deficiency. (frontiersin.org)
Hypothyroidism1
- He had a history of hypertension, schizophrenia, hypothyroidism and factor XII deficiency. (biomedcentral.com)
Venous2
- Excess levels of factor XII can predispose individuals towards greater risk of venous thrombosis due to factor XII's role as one of the catalysts for conversion of plasminogen to its active fibrinolytic form of plasmin . (wikidoc.org)
- At this time a heparin infusion was initiated given the patient's known factor XII deficiency and demonstrated mesenteric venous thrombosis. (biomedcentral.com)
XIII6
- Congenital factor XIII deficiency is very rare, affecting only 1 in 2 million people - about 100-125 people in the US. (firebaseapp.com)
- Deficiency of factor XIII during and after CPB has been described, although the importance of this finding is uncertain. (firebaseapp.com)
- 143-146 Supplementation with human or recombinant factor XIII has been demonstrated to reduce bleeding after adult heart surgery, although possibly only in the presence of factor deficiency. (firebaseapp.com)
- ous attempt to detect and remedy their difficulties or their deficiencies if these Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII. (firebaseapp.com)
- Factor XIII deficiency is a rare bleeding disorder. (firebaseapp.com)
- Factor XIII Deficiency Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. (firebaseapp.com)
Diseases1
- Background: The adipocyte products, leptin and tumour necrosis factor (TNF)alpha are associated with atherosclerotic diseases and may be factors contributing to the enhanced cardiovascular risk in hypopituitary patients with growth hormone (GH) deficiency. (lu.se)
Hemostasis4
- Factor XII, HK, and PK are necessary for a normal aPTT, but they do not appear to be required for normal hemostasis. (medscape.com)
- Targeted deletion of factor XII in a mouse model does not impair hemostasis but does result in reduced generation of inflammatory mediators. (medscape.com)
- [ 7 ] Therefore, activation of the contact factors plays a much bigger role in thrombosis than hemostasis. (medscape.com)
- Monroe DM HM, Roberts HR. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis. (medscape.com)
Zymogen1
- This gene encodes coagulation factor XII which circulates in blood as a zymogen. (nih.gov)
Patients12
- For use in patients with blood coagulation deficiencies. (medscape.com)
- Girolami A, Scandellari R, Lombardi AM, Girolami B, Bortoletto E, Zanon E. Pregnancy and oral contraceptives in factor V deficiency: a study of 22 patients (five homozygotes and 17 heterozygotes) and review of the literature. (medscape.com)
- During January-March 2014, we reviewed risk factors CMRs were lower, but still substantial, for patients receiv- for dissemination and summarized all coccidioidomycosis ing steroids (https://www.niaid.nih.gov/sites/default/files/ cases in patients with primary immunodeficiency (PID). (cdc.gov)
- After 12 weeks of treatment, the effect of CM on patients without deficiency-syndrome was better than the patients with deficiency-syndrome. (jcimjournal.com)
- Coagadex is used to treat and control bleeding in patients aged 12 years and over with hereditary Factor X deficiency. (rxwiki.com)
- Addition of polyphosphates restored defective plasma clotting of Hermansky-Pudlak syndrome patients, indicating that the inorganic polymer is the endogenous factor XII activator in vivo. (wikidoc.org)
- A good understanding of the possible risk factors for coronavirus disease 19 (COVID-19) severity could help clinicians in identifying patients who need prioritized treatment to prevent disease progression and adverse outcomes. (bvsalud.org)
- However, the researchers note, obesity is a well-known risk factor for vitamin D deficiency, and patients preparing to undergo weight loss operations should be screened for it. (hopkinsmedicine.org)
- The growing rates of obesity and increased popularity of bariatric surgeries mean that primary care clinicians and bariatric surgeons should consider screening their patients and correcting any confirmed vitamin D deficiency," says Peterson. (hopkinsmedicine.org)
- Patients must eat foods containing vitamin B-12 such as red meat, eggs, shellfish, poultry and dairy products in order to prevent vitamin B-12 deficiency. (healthfully.com)
- Some patients may find benefit from vitamin B-12 tablets, multivitamins containing vitamin B-12 and changes in diet. (healthfully.com)
- PETTS was a prospective observational study of patients with MDR TB in 9 countries, studying risk factors for, and the consequences of acquired drug resistance in the treatment of MDR TB. (cdc.gov)
Fibrinolysis1
- However, factor XII, HK, PK and complement factor C1q participate in inflammatory responses that involve blood coagulation, fibrinolysis, and generation of kinins. (medscape.com)
Vivo1
- In vivo, factor XII is activated by contact to polyanions. (wikidoc.org)
Risk factors3
- Objective: The purpose of this study was to evaluate folate and vitamin B-12 intake, status, and risk factors for deficiency before implementation of a national fortification program in Cameroon. (ihsn.org)
- Furthermore, the severity of infection was observed to increase with risk factors such as age, heart disease, hypertension, and DM eventually affecting COVID-19 prognosis and mortality. (bvsalud.org)
- Later, male sex, obesity, and possessing naturally melanin-rich skin while living outside of the tropics came to be known as the highest risk factors after older age ( 2 p , 8 - 13 , 14 p , 15 , 16 ). (frontiersin.org)
Syndrome2
- Although Alzheimer disease (AD) is more frequent in individuals with Down syndrome (DS), the main contributing factor is unknown. (medscape.com)
- A 12-year-old girl with Noonan syndrome, displaying typical webbed neck and double structural curve with rib deformity. (handwiki.org)
Antithrombin1
- Activated factor XI can be inactivated by antithrombin III, alpha1-protease inhibitor, C1 inhibitor, and alpha2-antiplasmin. (medscape.com)
Blood8
- [ 1 ] Blood coagulation is triggered by the exposure of tissue factor at injury sites and its interaction with activated factor VII, leading to the generation of minute quantities of thrombin. (medscape.com)
- Factor XII is responsible for the contact activation of blood coagulation as seen in the activated partial thromboplastin time test (aPTT). (medscape.com)
- Factor X deficiency is an inherited bleeding disorder that prevents blood from clotting normally. (rxwiki.com)
- It belongs to a group of drugs called blood coagulation factors. (rxwiki.com)
- Hepatocytes express blood coagulation factor XII. (wikidoc.org)
- Characterization of the human blood coagulation factor XII gene. (wikidoc.org)
- Vitamin B-12 is a water-soluble vitamin that is important in the production of healthy red blood cells and in the maintenance of healthy nerve cells, according to MayoClinic.com 1 . (healthfully.com)
- Vascular factors reduce blood loss due to trauma through local vasoconstriction (an immediate reaction to injury) and compression of injured vessels by extravasation of blood into surrounding tissues. (msdmanuals.com)