Infection of cattle and other herbivores with the giant liver fluke Fascioloides magna. It is characterized by extensive destruction of the liver parenchyma.

Natural infection of a horse with Fascioloides magna. (1/3)

A 25-year-old Quarterhorse mare was euthanized for a variety of medical reasons. At necropsy, 7 liver flukes, identified as Fascioloides magna, were recovered from the liver. This is the first report of F. magna in a horse.  (+info)

Prognostic significance of microsatellite alterations at 1p36 in cholangiocarcinoma. (2/3)

AIM: To investigate loss of heterozygosity (LOH) and microsatellite instability (MSI) on the chromosomal region 1p36-pter in cholangiocarcinoma (CCA) patients and determine the association between microsatellite alterations and clinicopathological parameters. METHODS: Ten polymorphic microsatellite markers were determined for LOH and MSI using GS-3000 gel scan fragment autoanalyzer. RESULTS: Sixty-eight out of 90 cases (75.6%) showed LOH in one or more loci. LOH was found most frequently at D1S199 (40.0%), D1S507 (34.6%), D1S2845 (30.5%), and D1S2734 (30.1%). MSI was found in 34 of 90 cases (37.8%) at one or more loci. Fine mapping at 1p36 showed two distinctive regions of common loss, which were D1S2845 and the 25.5-cM region between D1S507 and D1S2734, indicating the existence of putative tumor suppressor genes that is likely to play important roles in the development of CCA. Patients with LOH at D1S234 showed less lymphatic invasion (P = 0.017), whereas patients with LOH at D1S2676 exhibited more lymphatic invasion than those without (P = 0.031). LOH at D1S2845 showed a significant correlation with nerve invasion (P = 0.029). Moreover, patients who demonstrated MSI at D1S228 showed a poor prognosis (P = 0.0026). CONCLUSION: Allelic loss plays a major role in microsatellite alterations at chromosome 1p36, which may contribute to carcinogenesis and pathogenesis of liver fluke related CCA and these alterations can be used as molecular prognostic indicators for CCA patients.  (+info)

Pathogenicity of immature Fascioloides magna in white-tailed deer. (3/3)

The pathogenesis of early prepatent Fascioloides magna infection was investigated in seven fawns (Odocoileus virginianus) given 500 metacercariae and examined at one, two, three, five, eight, 12 and 13 weeks postinoculation. Blood samples were taken from eight inoculated deer every two weeks up to 16 weeks postinoculation. Eosinophilia with a mild transitory anemia were the main clincopathological features. Postmortem examination at two weeks postinoculation revealed extensive migration of immature flukes. Subcapsular tracks in the liver, nodules on the blind sacs of the rumen, as well as retroperitoneal granulomas on flanks and necrotic tracks on the diaphragm were found. Evidence of penetration of flukes into the lung was found at two weeks postinoculation and there was early granuloma formation at three weeks postinoculation. Flukes migrating into tissues other than the liver were destroyed in large granulomas, although remnants of degenerating parasites were not found. At eight weeks postinoculation, widespread granuloma formation characterized the infection with this lesion present in nodes along the gastrointestinal tract, in the mesentery, flanks, psoas muscles, diaphragm, between the ribs and in the lungs. By 12 weeks postinoculation subcapsular tracks were observed in the liver.  (+info)

Fascioloidiasis is a parasitic disease caused by the fluke Fascioloides magna, also known as the giant liver fluke. This flatworm primarily infects herbivorous animals such as sheep, goats, and cattle, but it can also occasionally infect humans.

The life cycle of Fascioloides magana involves several stages, including aquatic larval stages that infect snails as the first intermediate host. The parasite then develops into a free-swimming stage called a cercaria, which encysts on vegetation and is ingested by the definitive host. Once inside the host, the parasite excysts in the duodenum and migrates to the liver, where it causes damage to the bile ducts and liver parenchyma.

Humans can become accidentally infected with Fascioloides magna by ingesting contaminated water or vegetables. The symptoms of fascioloidiasis in humans are similar to those seen in animals and include fever, abdominal pain, diarrhea, and liver enlargement. In severe cases, the disease can lead to chronic liver damage and fibrosis.

Preventive measures for fascioloidiasis include avoiding consumption of raw or undercooked aquatic plants, improving sanitation and hygiene practices, and controlling snail populations in areas where the parasite is endemic. There are limited treatment options available for fascioloidiasis, but drugs such as triclabendazole and praziquantel have been used to treat the disease in animals and humans.

Kingscote AA (1950). "Liver rot (fascioloidiasis) in ruminants". Can J Comp Med. 14 (6): 203-8. PMC 1791121. PMID 15427015. ... Campbell WC (December 1960). "Nature and possible significance of the pigment in fascioloidiasis". J. Parasitol. 46 (6): 769-75 ... pathology of fascioloidiasis magna, and control measures". Canadian Journal of Research. 12 (2): 177-215. Bibcode:1935CJRes..12 ...
... fascioloidiasis MeSH C22.674.377.656 - monieziasis MeSH C22.674.377.820 - setariasis MeSH C22.674.377.840 - strongyle ...
... fascioloidiasis MeSH C03.335.349.656 - monieziasis MeSH C03.335.349.820 - setariasis MeSH C03.335.349.840 - strongyle ... fascioloidiasis MeSH C03.701.377.656 - monieziasis MeSH C03.701.377.820 - setariasis MeSH C03.701.377.840 - strongyle ... fascioloidiasis MeSH C03.335.865.685 - opisthorchiasis MeSH C03.335.865.741 - paragonimiasis MeSH C03.335.865.859 - ...
Kingscote AA (1950). "Liver rot (fascioloidiasis) in ruminants". Can J Comp Med. 14 (6): 203-8. PMC 1791121. PMID 15427015. ... Campbell WC (December 1960). "Nature and possible significance of the pigment in fascioloidiasis". J. Parasitol. 46 (6): 769-75 ... pathology of fascioloidiasis magna, and control measures". Canadian Journal of Research. 12 (2): 177-215. Bibcode:1935CJRes..12 ...
ID: DOID:0080029 Type: http://bio2vec.net/ontology/disease Label: autosomal recessive spinocerebellar ataxia 16 Synonyms: autosomal recessive spinocerebellar ataxia 16 Alternative IDs: als API: GO SPARQL: GO ...
FASCIOLOIDIASIS] 75. ՖԵՆԻԼՄԻԶԱՆՅՈՒԹԻ ՄԻԱՑՈՒԹՅՈՒՆՆԵՐ [PHENYLUREA COMPOUNDS] 26. ՖԱՎԻԶՄ [FAVIZM] 76. ՖԵՆԻԼՊԻՐՈԽԱՂՈՂԱԹԹՈՒՆԵՐ [ ...
Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis. Vet Immunol Immunopathol. 1997 Dec 12; 60(1-2):33-46 ...
... pathology of Fascioloidiasis magna, and control measures. Can J Res. 1935, 12: 177-215. 10.1139/cjr35-015. ...
Fascioloidiasis [C22.674.377.444] * Monieziasis [C22.674.377.656] * Setariasis [C22.674.377.820] * Strongyle Infections, Equine ...
Fascioloidiasis / drug therapy* Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Fascioloidiasis Preferred Term Term UI T015984. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1968). ... Fascioloidiasis. Tree Number(s). C01.610.335.349.444. C01.610.335.865.399. C01.610.701.377.444. C22.674.377.444. Unique ID. ... Fascioloidiasis Preferred Concept UI. M0008246. Scope Note. Infection of cattle and other herbivores with the giant liver fluke ...
Fascioloidiasis Preferred Term Term UI T015984. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1968). ... Fascioloidiasis. Tree Number(s). C01.610.335.349.444. C01.610.335.865.399. C01.610.701.377.444. C22.674.377.444. Unique ID. ... Fascioloidiasis Preferred Concept UI. M0008246. Scope Note. Infection of cattle and other herbivores with the giant liver fluke ...
Fascioloidiasis - Preferred Concept UI. M0008246. Scope note. Infection of cattle and other herbivores with the giant liver ... fascioloidiasis. Scope note:. Infección de los bovinos y de otros herbívoros producida por un trematodo hepático gigante, ...
FASCIOLOIDIASIS] 75. ՖԵՆԻԼՄԻԶԱՆՅՈՒԹԻ ՄԻԱՑՈՒԹՅՈՒՆՆԵՐ [PHENYLUREA COMPOUNDS] 26. ՖԱՎԻԶՄ [FAVIZM] 76. ՖԵՆԻԼՊԻՐՈԽԱՂՈՂԱԹԹՈՒՆԵՐ [ ...
X FASCIoLOIDIASIS if applic >. pre-coordinated animal/diseases heading liver sclerosis A LIVER CIRRHOSIS LL ractor X FACTOR ... X FASCIOLOIDIASIS Fascioloides magna X TRLKATODA Fasciolopsis infection X TREMATODE INFECTIONS X FASCIOLOPSIS ♦rastigial ...
Fascioloidiasis [C01.610.335.865.399] * Opisthorchiasis [C01.610.335.865.685] * Paragonimiasis [C01.610.335.865.741] ...
Fascioloidiasis [C01.610.335.865.399] * Opisthorchiasis [C01.610.335.865.685] * Paragonimiasis [C01.610.335.865.741] ...
Plantar Fasciola Fasciola hepatica Fascioliasis Fasciolidae Fascioloidiasis Fast Foods Fast Neutrons Fasting Fat Body Fat ...

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