A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)
A benign tumor of fibrous or fully developed connective tissue.
A relatively large mass of unusually firm scarlike connective tissue resulting from active participation of fibroblasts, occurring most frequently in the abdominal muscles of women who have borne children. The fibroblasts infiltrate surrounding muscle and fascia. (Stedman, 25th ed)
Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
Oral tissue surrounding and attached to TEETH.
'Gingival diseases' is a general term for conditions affecting the soft tissues surrounding and supporting the teeth, primarily characterized by inflammation, bleeding, redness, or swelling, which can progress to periodontal disease if left untreated.
Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
Surgical excision of the gingiva at the level of its attachment, thus creating new marginal gingiva. This procedure is used to eliminate gingival or periodontal pockets or to provide an approach for extensive surgical interventions, and to gain access necessary to remove calculus within the pocket. (Dorland, 28th ed)
Abnormal enlargement or overgrowth of the gingivae brought about by enlargement of existing cells.
Inflammation of gum tissue (GINGIVA) without loss of connective tissue.
'Gingival neoplasms' are abnormal, uncontrolled growths of tissue originating from the gingiva, which can be benign (non-cancerous) or malignant (cancerous), often manifesting as swellings, ulcerations, or masses within the oral cavity.
A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
An abnormal extension of a gingival sulcus not accompanied by the apical migration of the epithelial attachment.
Autosomal recessive disorder characterized by HYALINE deposition in the skin, bone, gastrointestinal tract, muscles and glands; multiple subcutaneous skin nodules; GINGIVAL HYPERTROPHY; and joint CONTRACTURES. Mutations in the capillary morphogenesis protein-2 are associated with the disorder.
A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.
A extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)
A 'Fissured Tongue' is a benign condition characterized by deep, linear grooves or fissures on the dorsal surface of the tongue, which can vary in number and depth, and may be associated with geographic tongue or Down syndrome, but is often asymptomatic.
The anteriorly located rigid section of the PALATE.
Congenital absence of or defects in structures of the teeth.
A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)
A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.
A genus of the family HERPESVIRIDAE, subfamily GAMMAHERPESVIRINAE, infecting New World primates and other species. HERPESVIRUS 2, SAIMIRIINE is the type species.
Pathological development in the ILEUM including the ILEOCECAL VALVE.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).
An index which scores the degree of dental plaque accumulation.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
A condition chiefly characterized by thickening of the skin of the head and distal extremities, deep folds and furrows of the skin of the forehead, cheeks, and scalp, SEBORRHEA; HYPERHIDROSIS; periostosis of the long bones, digital clubbing, and spadelike enlargement of the hands and feet. It is more prevalent in the male, and is usually first evident during adolescence. Inheritance is primarily autosomal recessive, but an autosomal dominant form exists.
Maxillary diseases refer to various medical conditions primarily affecting the maxilla (upper jaw) bone, including inflammatory processes, tumors, cysts, or traumatic injuries, which may cause symptoms such as pain, swelling, or functional impairment.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
A benign tumor that consists chiefly of fibrous CONNECTIVE TISSUE, with variable numbers of MUSCLE CELLS forming portions of the neoplasm (From Stedman's, 27th ed).
A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.
'Dental pulp calcification' is a pathological condition characterized by the deposition of hard tissue within the pulp chamber and root canal(s), which can result in the obliteration of pulpal space, potentially leading to various clinical symptoms such as pain or dental sensitivity.
The neck muscles consist of the platysma, splenius cervicis, sternocleidomastoid(eus), longus colli, the anterior, medius, and posterior scalenes, digastric(us), stylohyoid(eus), mylohyoid(eus), geniohyoid(eus), sternohyoid(eus), omohyoid(eus), sternothyroid(eus), and thyrohyoid(eus).
A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Disorders of the mediastinum, general or unspecified.
Thoracic neoplasms are a broad category of abnormal growths or tumors that originate within the thorax, encompassing malignant (cancerous) and benign (non-cancerous) forms, which can affect structures such as the lungs, pleura, mediastinum, and chest wall.
High-amplitude compression waves, across which density, pressure, and particle velocity change drastically. The mechanical force from these shock waves can be used for mechanically disrupting tissues and deposits.
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.
Retroperitoneal neoplasms are a diverse group of tumors that originate in the retroperitoneal space, which is the area behind the peritoneum and includes the kidneys, adrenal glands, pancreas, and major blood vessels.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.
Developmental bone diseases are a category of skeletal disorders that arise from disturbances in the normal growth and development of bones, including abnormalities in size, shape, structure, or composition, which can lead to various musculoskeletal impairments and deformities.
A wedge-shaped collar of epithelial cells which form the attachment of the gingiva to the tooth surface at the base of the gingival crevice.
Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.
The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
A TCF transcription factor that was originally identified as a DNA-binding protein that interacts with the enhancers of T-CELL RECEPTOR ALPHA GENES. It plays a role in T-LYMPHOCYTE development.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Surgical reshaping of the gingivae and papillae for correction of deformities (particularly enlargements) and to provide the gingivae with a normal and functional form, the incision creating an external bevel. (Dorland, 28th ed)
Anatomical and functional disorders affecting the foot.
Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Techniques used to expose dental surface below the gingival margin in order to obtain better dental impression during periodental and peri-implant applications. The retraction of the gingival tissue can be achieved surgically (e.g., laser gingivectomy and rotary curettage) or chemically with a retraction cord.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
A species of gram-negative, anaerobic, rod-shaped bacteria isolated from the gingival margin and sulcus and from infections of the upper respiratory tract and pleural cavity.
A procedure for smoothing of the roughened root surface or cementum of a tooth after subgingival curettage or scaling, as part of periodontal therapy.
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.
Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Removal of dental plaque and dental calculus from the surface of a tooth, from the surface of a tooth apical to the gingival margin accumulated in periodontal pockets, or from the surface coronal to the gingival margin.
The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A characteristic symptom complex.
A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Infections with bacteria of the family BACTEROIDACEAE.
Devices used in the home by persons to maintain dental and periodontal health. The devices include toothbrushes, dental flosses, water irrigators, gingival stimulators, etc.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
Orthodontic techniques used to correct the malposition of a single tooth.

Genetic heterogeneity of gingival fibromatosis on chromosome 2p. (1/24)

Gingival fibromatosis (GF) occurs in several genetic forms as a simple Mendelian trait, in malformation syndromes, and in some chromosomal disorders. Specific genes responsible for GF have not been identified. An autosomal dominant form of hereditary gingival fibromatosis (HGF, MIM 135300) was recently mapped to chromosome 2p21 in a large Brazilian family and there was an earlier report of GF in a boy with a cytogenetic duplication involving 2p13-->p21. We thus hypothesised that a common gene locus may be responsible for GF in both the Brazilian family and the boy with the chromosome 2p duplication. We performed additional genetic linkage studies on the Brazilian family and molecular cytogenetic studies on the patient with the cytogenetic duplication to correlate more precisely the genetic interval of the HGF phenotype with the duplicated 2p interval. Additional linkage analysis of new family members resulted in refinement of the candidate region for HGF to an 8 Mb region. Molecular cytogenetic analysis of the 2p13-->p21 duplication associated with GF showed that the duplicated region was proximal to the candidate interval for HGF. Thus, our results support the presence of two different gene loci on chromosome 2p that are involved in GF.  (+info)

A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. (2/24)

Hereditary gingival fibromatosis (HGF) is a rare, autosomal dominant form of gingival overgrowth. Affected individuals have a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa. Genetic loci for autosomal dominant forms of HGF have been localized to chromosome 2p21-p22 (HGF1) and chromosome 5q13-q22 (HGF2). To identify the gene responsible for HGF1, we extended genetic linkage studies to refine the chromosome 2p21-p22 candidate interval to approximately 2.3 Mb. Development of an integrated physical and genetic map of the interval identified 16 genes. Sequencing of these genes, in affected and unaffected HGF1 family members, identified a mutation in the Son of sevenless-1 (SOS1) gene in affected individuals. In this report, we describe the genomic structure of the SOS1 gene and present evidence that insertion of a cytosine between nucleotides 126,142 and 126,143 in codon 1083 of the SOS1 gene is responsible for HGF1. This insertion mutation, which segregates in a dominant manner over four generations, introduces a frameshift and creates a premature stop codon, abolishing four functionally important proline-rich SH3 binding domains normally present in the carboxyl-terminal region of the SOS1 protein. The resultant protein chimera contains the wild-type SOS1 protein for the N-terminal amino acids 1-1083 fused to a novel 22-amino acid carboxyl terminus. Similar SOS1 deletion constructs are functional in animal models, and a transgenic mouse construct with a comparable SOS1 chimera produces a phenotype with skin hypertrophy. Clarification of the functional role of this SOS1 mutant has implications for understanding other forms of gingival fibromatosis and corrective gingival-tissue management.  (+info)

Treatment and long-term follow-up of a patient with hereditary gingival fibromatosis: a case report. (3/24)

This report addresses the complex nature of oral diagnosis, treatment and long-term case management in the hereditary form of recurrent gingival fibromatosis. Case management is discussed in relation to a 13-year-old girl who presented with recurrent, progressive gingival enlargement requiring consecutive periodontal and orthodontic treatment. The initial course of treatment included 4-quadrant gingivectomy with reverse bevel incisions, followed by orthodontics. Microscopic examination of the gingivectomy specimens supported the clinical diagnosis. Three years later, recurrence of the condition was observed in all quadrants. To facilitate orthodontic tooth movement and to achieve optimal esthetics, another full-mouth gingivectomy was performed. There was no recurrence of the condition a year later. It is recommended that patients with this condition be monitored closely after gingivectomy, so that the treatment requirements of localized areas can be addressed as needed.  (+info)

Idiopathic gingival hyperplasia and orthodontic treatment: a case report. (4/24)

There are many reasons for gingival hyperplasia. Mostly, proper oral hygiene is sufficient to achieve normal healthy gingiva. In some situations, however, gingival hyperplasia is drug-induced or can be a manifestation of a genetic disorder. In the latter, it may exist as an isolated abnormality or as part of a syndrome. If orthodontic treatment is needed in patients with gingival hyperplasia, both orthodontic and periodontal aspects need to be considered. Extreme hereditary gingival fibromatosis was periodontally treated, by removal of all gingival excess using flaps and gingivectomies. After a follow-up period, the orthodontic treatment started with fixed appliances. Monthly periodontal check-ups (scaling and polishing) were scheduled to control the gingival inflammation. After the orthodontic treatment, permanent retention was applied, once more followed by a complete gingivectomy in both maxilla and mandible. One of the most important keys to successful treatment of hyperplasia patients is the cooperation between the periodontist and the orthodontist.  (+info)

Removal of hyperplastic lesions of the oral cavity. A retrospective study of 128 cases. (5/24)

AIMS: Based on our accumulated experience, the present study evaluates and discusses the indications, advantages and inconveniences of oral cavity epulis resection using the carbon dioxide laser (CO2) versus the Erbium:YAG laser (Er:YAG), diode laser and surgical scalpel. MATERIAL AND METHODS: A retrospective study has been made of 120 patients involving the removal of 128 epulis lesions with the CO2 laser, Er:YAG laser, diode laser and surgical scalpel. Postoperative controls were carried out after 7, 15 and 30 days to evaluate healing and wound evolution, and after 3, 6 and 12 months to assess possible relapse. RESULTS: Two groups were defined, based on the clinical and etiopathogenic characteristics of the excised lesions: gingival hyperplastic lesions (77 cases) and fibromatous hyperplasia (51 cases). The lower jaw was the most frequent location of gingival hyperplasia (51.9%). Fibrous hyperplasia was the most common histological diagnosis (49 cases; 63.6%). Percentage relapse following removal was 9.1%, of which 5 cases corresponded to fibrous hyperplasia. Only one malignancy was identified, corresponding to infiltrating squamous cell carcinoma. On the other hand, of the 51 treated cases of fibromatous hyperplasia, 58.8% were located in the upper jaw. These were histologically confirmed to be fibrous hyperplasia, with relapse in 19.6% of the cases. CONCLUSIONS: Although the different surgical techniques used for removal of epulis of the oral cavity are appropriate, we consider the CO2 laser to be the treatment of choice, since it offers a number of both intra- and postoperative advantages. On the other hand, all oral lesions require histological study to establish a firm diagnosis.  (+info)

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. (6/24)

CCN2, (connective tissue growth factor, CTGF) is a matricellular factor associated with fibrosis that plays an important role in the production and maintenance of fibrotic lesions. Increased collagen deposition and accumulation is a common feature of fibrotic tissues. The mechanisms by which CCN2/CTGF contributes to fibrosis are not well understood. Previous studies suggest that CTGF exerts some of its biological effects at least in part by integrin binding, though this mechanism has not been previously shown to contribute to fibrosis. Utilizing full length CCN2/CTGF, CCN2/CTGF fragments, and integrin neutralizing antibodies, we provide evidence that the effects of CCN2/CTGF to stimulate extracellular matrix deposition by gingival fibroblasts are mediated by the C-terminal half of CCN2/CTGF, and by alpha6 and beta1 integrins. In addition, a synthetic peptide corresponding to a region of CCN2/CTGF domain 3 that binds alpha6beta1 inhibits the collagen-deposition assay. These studies employed a new and relatively rapid assay for CCN2/CTGF-stimulated collagen deposition based on Sirius Red staining of cell layers. Data obtained support a pathway in which CCN2/CTGF could bind to alpha6beta1 integrin and stimulate collagen deposition. These findings provide new experimental methodologies applicable to uncovering the mechanism and signal transduction pathways of CCN2/CTGF-mediated collagen deposition, and may provide insights into potential therapeutic strategies to treat gingival fibrosis and other fibrotic conditions.  (+info)

Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. (7/24)

Gingival overgrowth is a side effect of certain medications and occurs in non-drug-induced forms either as inherited (human gingival fibromatosis) or idiopathic gingival overgrowth. The most fibrotic drug-induced lesions develop in response to therapy with phenytoin; the least fibrotic lesions are caused by cyclosporin A; and intermediate fibrosis occurs in nifedipine-induced gingival overgrowth. Connective tissue growth factor (CTGF/CCN2) expression is positively related to the degree of fibrosis in these tissues. The present study has investigated the hypothesis that CTGF/CCN2 is expressed in human gingival fibromatosis tissues and contributes to this form of non-drug-induced gingival overgrowth. Histopathology/immunohistochemistry studies showed that human gingival fibromatosis lesions are highly fibrotic, similar to phenytoin-induced lesions. Connective tissue CTGF/CCN2 levels were equivalent to the expression in phenytoin-induced gingival overgrowth. The additional novel observation was made that CTGF/CCN2 is highly expressed in the epithelium of fibrotic gingival tissues. This finding was confirmed by in situ hybridization. Real-time polymerase chain reaction (PCR) analyses of RNA extracted from drug-induced gingival overgrowth tissues for CTGF/CCN2 were fully consistent with these findings. Finally, normal primary gingival epithelial cell cultures were analysed for basal and transforming growth factor beta1 (TGF-beta1) or lysophosphatidic acid-stimulated CTGF/CCN2 expression at protein and RNA levels. These data indicate that fibrotic human gingival tissues express CTGF/CCN2 in both the epithelium and connective tissues; that cultured gingival epithelial cells express CTGF/CCN2; and that lysophosphatidic acid further stimulates CTGF/CCN2 expression. These findings suggest that interactions between epithelial and connective tissues could contribute to gingival fibrosis.  (+info)

Characterization of fibroblasts with Son of Sevenless-1 mutation. (8/24)

Although non-syndromic hereditary gingival fibromatosis (HGF) is genetically heterogeneous, etiologic mutations have been identified only in the Son of Sevenless-1 gene (SOS1). To test evidence of increased cell proliferation, we studied histological, morphological, and proliferation characteristics in monolayer and three-dimensional cultures of fibroblasts with the SOS1 g.126,142-126,143insC mutation. Histological assessment of HGF gingiva indicated increased numbers of fibroblasts (30%) and increased collagen (10%). Cell proliferation studies demonstrated increased growth rates and 5-bromo-2-deoxyuridine incorporation for HGF fibroblasts. Flow cytometry showed greater proportions of HGF fibroblasts in the G2/M phase. Attachment of HGF fibroblasts to different extracellular matrix surfaces demonstrated increased formation of protrusions with lamellipodia. HGF fibroblasts in three-dimensional culture showed greater cell proliferation, higher cell density, and alteration of surrounding collagen matrix. These findings revealed that increased fibroblast numbers and collagen matrix changes are associated with mutation of the SOS1 gene in vitro and in vivo.  (+info)

Aggressive fibromatosis, also known as Desmoid tumor or Desmoid-type fibromatosis, is a rare, non-cancerous (benign) connective tissue neoplasm. It is characterized by the proliferation of fibroblasts and excessive deposition of collagen in the affected area.

Aggressive fibromatosis typically involves the deep soft tissues such as muscle, fascia, or aponeurosis. The tumor can grow aggressively, invading surrounding tissues but rarely metastasizing to distant organs. It can cause significant morbidity due to local invasion and destruction of adjacent structures.

The exact cause of aggressive fibromatosis is unknown, although it has been associated with genetic mutations in the beta-catenin gene (CTNNB1) or familial adenomatous polyposis (FAP). Treatment options for aggressive fibromatosis include surgical resection, radiation therapy, medical management with nonsteroidal anti-inflammatory drugs (NSAIDs), and targeted therapies such as tyrosine kinase inhibitors. The choice of treatment depends on the location, size, growth rate, and symptoms associated with the tumor.

A fibroma is a benign (non-cancerous) tumor that consists primarily of fibrous or connective tissue. It can occur in various parts of the body, including the skin, mouth, and internal organs. The term "fibroma" is often used to describe any benign fibrous growth, but there are specific types of fibromas such as dermatofibroma (found in the skin), oral fibroma (found in the mouth), and benign fibrous histiocytoma (found in soft tissues).

It's important to note that while fibromas are generally harmless, they can cause discomfort or problems depending on their size and location. If a fibroma is causing issues or there's concern about its growth or malignancy, it should be evaluated by a healthcare professional for potential removal or further assessment.

Abdominal fibromatosis, also known as aggressive abdominal wall fibromatosis or desmoid tumors, are rare, non-cancerous (benign) growths that originate from the connective tissue in the abdominal wall. These tumors can be invasive and grow into surrounding tissues, causing discomfort, pain, or complications such as bowel obstruction. They can occur spontaneously or following surgical trauma, pregnancy, or familial adenomatous polyposis (FAP), a genetic disorder that increases the risk of colorectal cancer. Treatment options include surgery, radiation therapy, and medical management with anti-inflammatory drugs or chemotherapeutic agents. Regular follow-up is necessary due to the possibility of recurrence.

Gingival overgrowth, also known as gingival hyperplasia or hypertrophy, refers to an abnormal enlargement or growth of the gum tissue (gingiva) surrounding the teeth. This condition can be caused by various factors, including poor oral hygiene, certain medications (such as phenytoin, cyclosporine, and calcium channel blockers), genetic predisposition, and systemic conditions like vitamin C deficiency or leukemia.

Gingival overgrowth can lead to several complications, such as difficulty in maintaining oral hygiene, which may result in periodontal disease, tooth decay, bad breath, and potential loss of teeth. In some cases, the enlarged gum tissue may also cause discomfort or pain during speaking, chewing, or brushing. Treatment for gingival overgrowth typically involves improving oral hygiene, adjusting medications if possible, and undergoing surgical procedures to remove the excess gum tissue. Regular dental check-ups and cleanings are essential in managing and preventing this condition.

Gingiva is the medical term for the soft tissue that surrounds the teeth and forms the margin of the dental groove, also known as the gum. It extends from the mucogingival junction to the base of the cervical third of the tooth root. The gingiva plays a crucial role in protecting and supporting the teeth and maintaining oral health by providing a barrier against microbial invasion and mechanical injury.

Gingival diseases are infections or inflammations that affect the gingiva, which is the part of the gum around the base of the teeth. These diseases can be caused by bacteria found in dental plaque and can lead to symptoms such as redness, swelling, bleeding, and receding gums. If left untreated, gingival diseases can progress to periodontal disease, a more serious condition that can result in tooth loss. Common types of gingival diseases include gingivitis and periodontitis.

Gingival hyperplasia is a condition characterized by an abnormal growth or enlargement of the gingiva (gum tissue). This condition can be caused by various factors, including bacterial infection, certain medications (such as phenytoin, cyclosporine, and nifedipine), systemic diseases (such as leukemia, vitamin C deficiency, and Crohn's disease), and genetic disorders.

The enlarged gum tissue can be uncomfortable, irritated, and prone to bleeding, especially during brushing or flossing. It may also make it difficult to maintain good oral hygiene, which can increase the risk of dental caries and periodontal disease. Treatment for gingival hyperplasia typically involves improving oral hygiene, controlling any underlying causes, and in some cases, surgical removal of the excess tissue.

Gingival fibromatosis is a benign (non-cancerous) condition characterized by the excessive growth of gum (gingival) tissue. The overgrowth can affect one or both the maxilla (upper jaw) and mandible (lower jaw) and can lead to various dental and oral health issues, such as difficulty in chewing, speaking, and maintaining proper oral hygiene.

The etiology of gingival fibromatosis can be divided into two categories: hereditary and acquired. Hereditary gingival fibromatosis is often associated with genetic mutations, while acquired gingival fibromatosis can result from factors like chronic inflammation due to poor oral hygiene, certain medications (such as phenytoin, cyclosporine, or nifedipine), and systemic conditions (like leukemia).

The management of gingival fibromatosis typically involves surgical removal of the excess tissue. However, recurrence is common due to the condition's tendency for regrowth. Regular follow-ups with a dental professional are essential to monitor any potential regrowth and maintain good oral hygiene.

A gingivectomy is a dental procedure that involves the surgical removal or reshaping of the gum tissue (gingiva) to improve the health and appearance of the teeth and gums. This procedure is typically performed when the gums have become swollen, inflamed, or infected due to periodontal disease, which can cause the gums to recede and expose the tooth roots. By removing the affected gum tissue, a gingivectomy can help to eliminate pockets of bacteria and promote healthy gum growth.

During the procedure, a dental surgeon will use local anesthesia to numb the area and then carefully cut away the excess gum tissue using specialized instruments. The surgeon may also smooth and reshape the remaining gum tissue to create a more even and aesthetically pleasing appearance. After the procedure, patients may experience some discomfort, swelling, or bleeding, but these symptoms can typically be managed with over-the-counter pain medications and careful oral hygiene practices.

It's important to note that while a gingivectomy can help to improve the health of the gums and teeth, it is not a substitute for good oral hygiene habits. Regular brushing, flossing, and dental checkups are essential for maintaining healthy teeth and gums over the long term.

Gingival hypertrophy is a condition characterized by an abnormal enlargement or overgrowth of the gingiva (gum tissue). This can be caused due to various reasons such as inflammation from poor oral hygiene, certain medications like phenytoin and cyclosporine, or systemic conditions such as pregnancy, leukemia, and vitamin C deficiency.

The enlarged gums may appear swollen, red, and bleed easily. They can also cover the teeth, making cleaning difficult, which can further worsen the inflammation. Depending on the cause, treatment options may include improving oral hygiene, changing medications, or undergoing surgical procedures to remove the excess tissue.

Gingivitis is a mild form of gum disease (periodontal disease) that causes irritation, redness, swelling and bleeding of the gingiva, or gums. It's important to note that it is reversible with good oral hygiene and professional dental treatment. If left untreated, however, gingivitis can progress to a more severe form of gum disease known as periodontitis, which can result in tissue damage and eventual tooth loss.

Gingivitis is most commonly caused by the buildup of plaque, a sticky film of bacteria that constantly forms on our teeth. When not removed regularly through brushing and flossing, this plaque can harden into tartar, which is more difficult to remove and contributes to gum inflammation. Other factors like hormonal changes, poor nutrition, certain medications, smoking or a weakened immune system may also increase the risk of developing gingivitis.

Gingival neoplasms refer to abnormal growths or tumors that occur in the gingiva, which are the part of the gums that surround the teeth. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms include conditions such as fibromas, papillomas, and hemangiomas, while malignant neoplasms are typically squamous cell carcinomas.

Gingival neoplasms can present with a variety of symptoms, including swelling, bleeding, pain, and loose teeth. They may also cause difficulty with chewing, speaking, or swallowing. The exact cause of these neoplasms is not always known, but risk factors include tobacco use, alcohol consumption, poor oral hygiene, and certain viral infections.

Diagnosis of gingival neoplasms typically involves a thorough clinical examination, including a dental exam and biopsy. Treatment options depend on the type and stage of the neoplasm, but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular dental check-ups and good oral hygiene practices can help to detect gingival neoplasms at an early stage and improve treatment outcomes.

'Hyalin' is not a medical condition or disease, but rather a histological term used to describe a particular type of tissue structure. Hyalin refers to the homogeneous, translucent, and eosinophilic (pink) appearance of a tissue under a microscope due to the accumulation of an amorphous, acellular, and protein-rich matrix.

Hyalinization can occur in various tissues, including blood vessels, cardiac valves, cartilage, and other connective tissues. It is often associated with aging, injury, inflammation, or degenerative changes, such as those seen in hyaline membrane disease (a respiratory disorder in premature infants) or hypertrophic cardiomyopathy (thickening of the heart muscle).

In summary, Hyalin is a histological term used to describe the appearance of tissue under a microscope due to the accumulation of an amorphous, acellular, and protein-rich matrix.

A gingival pocket, also known as a sulcus, is a small space or groove between the gum tissue (gingiva) and the tooth. It's a normal anatomical structure found in healthy teeth and gums, and it measures about 1-3 millimeters in depth. The purpose of the gingival pocket is to allow for the movement of the gum tissue during functions such as eating, speaking, and swallowing.

However, when the gums become inflamed due to bacterial buildup (plaque) or other factors, the pocket can deepen, leading to the formation of a pathological gingival pocket. Pathological pockets are typically deeper than 3 millimeters and may indicate the presence of periodontal disease. These pockets can harbor harmful bacteria that can cause further damage to the gum tissue and bone supporting the tooth, potentially leading to tooth loss if left untreated.

Systemic hyalinosis is a very rare, progressive, and fatal genetic disorder characterized by the accumulation of abnormal protein deposits in various organs and tissues throughout the body. The condition is caused by mutations in the ANTXR2 gene, which provides instructions for making a protein that is involved in the formation and maintenance of blood vessels.

The abnormal protein deposits, known as hyaline, are composed of bundles of collagen fibers that become thickened and twisted due to the accumulation of glycosaminoglycans (GAGs). These protein deposits can affect the function of various organs, including the heart, lungs, kidneys, and gastrointestinal tract.

Systemic hyalinosis is typically diagnosed in infancy or early childhood and is characterized by a range of symptoms, including:

* Skin abnormalities, such as thickened, tight, and shiny skin that may be prone to tearing or blistering
* Difficulty feeding and swallowing due to thickening of the lining of the mouth and throat
* Respiratory problems, such as recurrent pneumonia and chronic cough
* Cardiovascular abnormalities, such as high blood pressure and heart failure
* Gastrointestinal issues, such as vomiting, diarrhea, and malabsorption
* Renal failure due to the accumulation of hyaline in the kidneys

There is no cure for systemic hyalinosis, and treatment is focused on managing symptoms and improving quality of life. The prognosis for individuals with this condition is poor, with most dying before the age of 10.

Dupuytren contracture is a medical condition that affects the hand, specifically the fascia, which is a layer of connective tissue beneath the skin of the palm. In this condition, the fascia thickens and shortens, causing one or more fingers to bend towards the palm and making it difficult to straighten them. The ring finger and little finger are most commonly affected, but the middle finger and thumb can also be involved.

The exact cause of Dupuytren contracture is not known, but it is more common in men than women and tends to run in families. It is also associated with certain medical conditions such as diabetes, seizures, and alcoholism. There is no cure for Dupuytren contracture, but treatments such as surgery or needle aponeurotomy can help relieve symptoms and improve hand function.

Desmoplastic fibroma is a very rare benign (non-cancerous) tumor of the connective tissue. It typically develops in the bones, but can also occur in soft tissues. The tumor is characterized by the overgrowth of collagen-producing cells (fibroblasts), leading to the formation of a firm, fibrous mass. Desmoplastic fibromas are slow-growing and typically do not spread to other parts of the body (metastasize). However, they can cause significant damage to the affected bone or tissue as they grow, potentially leading to fractures or deformities. Treatment usually involves surgical removal of the tumor.

A fissured tongue is a benign condition characterized by deep grooves or furrows on the surface of the tongue. These grooves can vary in number and depth, and they may cover the entire surface of the tongue or only appear in certain areas. A fissured tongue is also sometimes referred to as a "scrotal tongue" due to its appearance.

While a fissured tongue is usually asymptomatic and does not require treatment, it can occasionally be associated with other conditions such as down syndrome, oral cancer, or certain vitamin deficiencies. It may also increase the risk of tooth decay and gum disease due to the accumulation of food particles and bacteria in the grooves. In some cases, a fissured tongue may cause discomfort or pain, especially if it becomes infected or inflamed. If you have concerns about a fissured tongue or are experiencing symptoms related to this condition, it is recommended that you consult with a healthcare professional for further evaluation and treatment options.

The hard palate is the anterior, bony part of the roof of the mouth, forming a vertical partition between the oral and nasal cavities. It is composed of the maxilla and palatine bones, and provides attachment for the muscles of the soft palate, which functions in swallowing, speaking, and breathing. The hard palate also contains taste buds that contribute to our ability to taste food.

Tooth abnormalities refer to any variations or irregularities in the size, shape, number, structure, or development of teeth that deviate from the typical or normal anatomy. These abnormalities can occur in primary (deciduous) or permanent teeth and can be caused by genetic factors, environmental influences, systemic diseases, or localized dental conditions during tooth formation.

Some examples of tooth abnormalities include:

1. Microdontia - teeth that are smaller than normal in size.
2. Macrodontia - teeth that are larger than normal in size.
3. Peg-shaped teeth - teeth with a narrow, conical shape.
4. Talon cusps - additional cusps or points on the biting surface of a tooth.
5. Dens invaginatus - an abnormal development where the tooth crown has an extra fold or pouch that can trap bacteria and cause dental problems.
6. Taurodontism - teeth with large pulp chambers and short roots.
7. Supernumerary teeth - having more teeth than the typical number (20 primary and 32 permanent teeth).
8. Hypodontia - missing one or more teeth due to a failure of development.
9. Germination - two adjacent teeth fused together, usually occurring in the front teeth.
10. Fusion - two separate teeth that have grown together during development.

Tooth abnormalities may not always require treatment unless they cause functional, aesthetic, or dental health issues. A dentist can diagnose and manage tooth abnormalities through various treatments, such as fillings, extractions, orthodontic care, or restorative procedures.

Leg dermatoses is a general term that refers to various skin conditions affecting the legs. This can include a wide range of inflammatory, infectious, or degenerative diseases that cause symptoms such as redness, itching, scaling, blistering, or pigmentation changes on the leg skin. Examples of specific leg dermatoses include stasis dermatitis, venous eczema, contact dermatitis, lichen planus, psoriasis, and cellulitis among others. Accurate diagnosis usually requires a thorough examination and sometimes a biopsy to determine the specific type of dermatosis and appropriate treatment.

The Periodontal Index (PI) is not a current or widely used medical/dental term. However, in the past, it was used to describe a method for assessing and measuring the severity of periodontal disease, also known as gum disease.

Developed by Henry H. Klein and colleagues in 1978, the Periodontal Index was a scoring system that evaluated four parameters: gingival inflammation, gingival bleeding, calculus (tartar) presence, and periodontal pocket depths. The scores for each parameter ranged from 0 to 3, with higher scores indicating worse periodontal health. The overall PI score was the sum of the individual parameter scores, ranging from 0 to 12.

However, due to its limited ability to predict future disease progression and the introduction of more comprehensive assessment methods like the Community Periodontal Index (CPI) and the Basic Periodontal Examination (BPE), the use of the Periodontal Index has become less common in dental practice and research.

Rhadinovirus is a type of gammaherpesvirus that can infect various animals, including humans. In humans, the rhadinovirus species includes the Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8). This virus is associated with several diseases, such as Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease, particularly in people with weakened immune systems. Rhadinoviruses are characterized by their complex genome structure and ability to establish latency in infected host cells.

Ileal diseases refer to conditions that primarily affect the ileum, which is the final portion of the small intestine. The ileum plays a crucial role in nutrient absorption, particularly vitamin B12 and bile salts. Ileal diseases can cause various symptoms, including diarrhea, abdominal pain, weight loss, and malnutrition, depending on their nature and extent. Some common ileal diseases include:

1. Crohn's disease: A type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, including the ileum. Crohn's disease causes chronic inflammation, which can lead to symptoms such as diarrhea, abdominal pain, and fatigue.
2. Celiac disease: An autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals. In celiac disease, the immune system attacks the lining of the small intestine, including the ileum, causing inflammation and impaired nutrient absorption.
3. Intestinal tuberculosis: A bacterial infection caused by Mycobacterium tuberculosis that can affect any part of the gastrointestinal tract, including the ileum. Intestinal tuberculosis can cause symptoms such as abdominal pain, diarrhea, and weight loss.
4. Typhlitis: Also known as neutropenic enterocolitis, typhlitis is an inflammatory condition that affects the cecum and terminal ileum, typically in immunocompromised individuals. It can cause symptoms such as abdominal pain, fever, and diarrhea.
5. Meckel's diverticulum: A congenital condition characterized by a small pouch protruding from the wall of the ileum. While many people with Meckel's diverticulum do not experience symptoms, it can sometimes become inflamed or bleed, causing abdominal pain and rectal bleeding.
6. Lymphoma: A type of cancer that originates in the lymphatic system and can affect any part of the body, including the ileum. Ileal lymphoma can cause symptoms such as abdominal pain, diarrhea, and weight loss.

APC (Adenomatous Polyposis Coli) gene is a tumor suppressor gene that provides instructions for making a protein called adenomatous polyposis coli. This protein plays a crucial role in regulating the growth and division of cells in the colon and rectum. Specifically, it helps to maintain the stability of the cell's genetic material (DNA) by controlling the process of beta-catenin degradation.

When the APC gene is mutated or altered, it can lead to an accumulation of beta-catenin in the cell, which can result in uncontrolled cell growth and division. This can ultimately lead to the development of colon polyps, which are benign growths that can become cancerous over time if left untreated.

Mutations in the APC gene are associated with several inherited cancer syndromes, including familial adenomatous polyposis (FAP) and attenuated FAP (AFAP). These conditions are characterized by the development of numerous colon polyps at a young age, which can increase the risk of developing colorectal cancer.

There is no single medical definition for "Monkey Diseases." However, monkeys can carry and be infected with various diseases that are zoonotic, meaning they can be transmitted from animals to humans. Some examples include:

1. Simian Immunodeficiency Virus (SIV): A virus similar to Human Immunodeficiency Virus (HIV) that causes AIDS in monkeys. It is not typically harmful to monkeys but can cause AIDS in humans if transmitted, which is rare.
2. Herpes B Virus: Also known as Macacine herpesvirus 1 or Cercopithecine herpesvirus 1, it is a virus that commonly infects macaque monkeys. It can be transmitted to humans through direct contact with an infected monkey's saliva, eye fluid, or cerebrospinal fluid, causing a severe and potentially fatal illness called B encephalitis.
3. Tuberculosis (TB): Monkeys can contract and transmit tuberculosis to humans, although it is not common.
4. Simian Retrovirus (SRV): A virus that can infect both monkeys and great apes, causing immunodeficiency similar to HIV/AIDS in humans. It is not known to infect or cause disease in humans.
5. Various parasitic diseases: Monkeys can carry and transmit several parasites, including malaria-causing Plasmodium species, intestinal worms, and other parasites that can affect human health.

It's important to note that while monkeys can carry and transmit these diseases, the risk of transmission is generally low, and most cases occur in individuals who have close contact with monkeys, such as primatologists, zookeepers, or laboratory workers. Always follow safety guidelines when interacting with animals, including monkeys, to minimize the risk of disease transmission.

The dental plaque index (DPI) is a clinical measurement used in dentistry to assess the amount of dental plaque accumulation on a person's teeth. It was first introduced by Silness and Löe in 1964 as a method to standardize the assessment of oral hygiene and the effectiveness of oral hygiene interventions.

The DPI is based on a visual examination of the amount of plaque present on four surfaces of the teeth, including the buccal (cheek-facing) and lingual (tongue-facing) surfaces of both upper and lower first molars and upper and lower incisors. The examiner assigns a score from 0 to 3 for each surface, with higher scores indicating greater plaque accumulation:

* Score 0: No plaque detected, even after probing the area with a dental explorer.
* Score 1: Plaque detected by visual examination and/or probing but is not visible when the area is gently dried with air.
* Score 2: Moderate accumulation of soft deposits that are visible upon visual examination before air drying, but which can be removed by scraping with a dental explorer.
* Score 3: Abundant soft matter, visible upon visual examination before air drying and not easily removable with a dental explorer.

The DPI is calculated as the average score of all surfaces examined, providing an overall measure of plaque accumulation in the mouth. It can be used to monitor changes in oral hygiene over time or to evaluate the effectiveness of different oral hygiene interventions. However, it should be noted that the DPI has limitations and may not accurately reflect the presence of bacterial biofilms or the risk of dental caries and gum disease.

Periodontitis is a severe form of gum disease that damages the soft tissue and destroys the bone supporting your teeth. If left untreated, it can lead to tooth loss. It is caused by the buildup of plaque, a sticky film of bacteria that constantly forms on our teeth. The body's immune system fights the bacterial infection, which causes an inflammatory response. If the inflammation continues for a long time, it can damage the tissues and bones that support the teeth.

The early stage of periodontitis is called gingivitis, which is characterized by red, swollen gums that bleed easily when brushed or flossed. When gingivitis is not treated, it can advance to periodontitis. In addition to plaque, other factors that increase the risk of developing periodontitis include smoking or using tobacco products, poor oral hygiene, diabetes, a weakened immune system, and genetic factors.

Regular dental checkups and good oral hygiene practices, such as brushing twice a day, flossing daily, and using an antimicrobial mouth rinse, can help prevent periodontitis. Treatment for periodontitis may include deep cleaning procedures, medications, or surgery in severe cases.

Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis, is a rare hereditary disorder characterized by the thickening of the skin (pachydermia) and abnormal growth of the bones (periostitis). This condition primarily affects the bones and joints, causing pain, swelling, and limited mobility.

The key features of PHO include:

1. Digits: Clubbing of the fingers and toes, with overgrowth of the bone tissue at the ends of the digits (periostitis) leading to characteristic "drumstick" appearance.
2. Skin: Thickening of the skin, particularly on the face, hands, and feet, giving a leathery or rough texture. Seborrheic dermatitis and increased sweating may also be present.
3. Bones: Periosteal new bone formation, leading to painful swelling and enlargement of the affected bones, most commonly in the long bones of the legs and arms.
4. Joints: Arthritis-like symptoms, including joint pain, stiffness, and limited mobility.
5. Other features: May include coarse hair, high arched palate, and bowing of the limbs.

The exact cause of primary hypertrophic osteoarthropathy is not fully understood but is believed to involve genetic mutations affecting the regulation of bone growth and remodeling. It is typically inherited in an autosomal dominant pattern, meaning that a child has a 50% chance of inheriting the condition if one parent is affected.

Treatment for PHO focuses on managing symptoms and improving quality of life. This may include pain relief medications, physical therapy, and surgical interventions to correct bone deformities or improve joint mobility.

Maxillary diseases refer to conditions that affect the maxilla, which is the upper bone of the jaw. This bone plays an essential role in functions such as biting, chewing, and speaking, and also forms the upper part of the oral cavity, houses the upper teeth, and supports the nose and the eyes.

Maxillary diseases can be caused by various factors, including infections, trauma, tumors, congenital abnormalities, or systemic conditions. Some common maxillary diseases include:

1. Maxillary sinusitis: Inflammation of the maxillary sinuses, which are air-filled cavities located within the maxilla, can cause symptoms such as nasal congestion, facial pain, and headaches.
2. Periodontal disease: Infection and inflammation of the tissues surrounding the teeth, including the gums and the alveolar bone (which is part of the maxilla), can lead to tooth loss and other complications.
3. Maxillary fractures: Trauma to the face can result in fractures of the maxilla, which can cause pain, swelling, and difficulty breathing or speaking.
4. Maxillary cysts and tumors: Abnormal growths in the maxilla can be benign or malignant and may require surgical intervention.
5. Oral cancer: Cancerous lesions in the oral cavity, including the maxilla, can cause pain, swelling, and difficulty swallowing or speaking.

Treatment for maxillary diseases depends on the specific condition and its severity. Treatment options may include antibiotics, surgery, radiation therapy, or chemotherapy. Regular dental check-ups and good oral hygiene practices can help prevent many maxillary diseases.

Beta-catenin is a protein that plays a crucial role in gene transcription and cell-cell adhesion. It is a key component of the Wnt signaling pathway, which regulates various processes such as cell proliferation, differentiation, and migration during embryonic development and tissue homeostasis in adults.

In the absence of Wnt signals, beta-catenin forms a complex with other proteins, including adenomatous polyposis coli (APC) and axin, which targets it for degradation by the proteasome. When Wnt ligands bind to their receptors, this complex is disrupted, allowing beta-catenin to accumulate in the cytoplasm and translocate to the nucleus. In the nucleus, beta-catenin interacts with T cell factor/lymphoid enhancer-binding factor (TCF/LEF) transcription factors to activate the transcription of target genes involved in cell fate determination, survival, and proliferation.

Mutations in the genes encoding components of the Wnt signaling pathway, including beta-catenin, have been implicated in various human diseases, such as cancer, developmental disorders, and degenerative conditions.

Myofibroma is a benign, smooth muscle tumor that can occur in various parts of the body. It primarily affects infants and children, but it can also rarely be found in adults. Myofibromas are typically composed of myofibroblasts, which are cells that have features of both fibroblasts and smooth muscle cells. These tumors can be solitary or multiple and may appear as a single mass or as multiple nodules. They usually occur in the skin, soft tissues, bones, and visceral organs. Myofibromas are generally slow-growing and non-aggressive, and they often regress spontaneously over time. Treatment options include observation, surgical excision, or a combination of both, depending on the location, size, and symptoms associated with the tumor.

The mesentery is a continuous fold of the peritoneum, the double-layered serous membrane that lines the abdominal cavity, which attaches the stomach, small intestine, large intestine (colon), and rectum to the posterior wall of the abdomen. It provides blood vessels, nerves, and lymphatic vessels to these organs.

Traditionally, the mesentery was thought to consist of separate and distinct sections along the length of the intestines. However, recent research has shown that the mesentery is a continuous organ, with a single continuous tethering point to the posterior abdominal wall. This new understanding of the anatomy of the mesentery has implications for the study of various gastrointestinal diseases and disorders.

Dental pulp calcification, also known as pulp stones or denticles, refers to the formation of hard tissue within the pulp chamber of a tooth. The pulp chamber is the central part of a tooth that contains its nerves, blood vessels, and connective tissues.

Pulp calcification occurs when the soft tissue of the pulp gradually transforms into a harder, calcified substance. This can happen as a result of aging, injury, or inflammation in the pulp chamber. Over time, these calcifications can build up and make the pulp chamber smaller, which can potentially lead to problems with the tooth's nerve and blood supply.

While dental pulp calcification is not usually harmful on its own, it can cause issues if it becomes severe enough to compress the tooth's nerve or restrict blood flow. In some cases, calcifications may also make root canal treatment more difficult, as there may be less space to work within the pulp chamber.

Neck muscles, also known as cervical muscles, are a group of muscles that provide movement, support, and stability to the neck region. They are responsible for various functions such as flexion, extension, rotation, and lateral bending of the head and neck. The main neck muscles include:

1. Sternocleidomastoid: This muscle is located on either side of the neck and is responsible for rotating and flexing the head. It also helps in tilting the head to the same side.

2. Trapezius: This large, flat muscle covers the back of the neck, shoulders, and upper back. It is involved in movements like shrugging the shoulders, rotating and extending the head, and stabilizing the scapula (shoulder blade).

3. Scalenes: These three pairs of muscles are located on the side of the neck and assist in flexing, rotating, and laterally bending the neck. They also help with breathing by elevating the first two ribs during inspiration.

4. Suboccipitals: These four small muscles are located at the base of the skull and are responsible for fine movements of the head, such as tilting and rotating.

5. Longus Colli and Longus Capitis: These muscles are deep neck flexors that help with flexing the head and neck forward.

6. Splenius Capitis and Splenius Cervicis: These muscles are located at the back of the neck and assist in extending, rotating, and laterally bending the head and neck.

7. Levator Scapulae: This muscle is located at the side and back of the neck, connecting the cervical vertebrae to the scapula. It helps with rotation, extension, and elevation of the head and scapula.

"Macaca nemestrina," also known as the pig-tailed macaque, is not a medical term but a species name in biology. It refers to a specific species of monkey that is native to Southeast Asia. The pig-tailed macaque is a medium-sized monkey with a reddish-brown fur and a distinctive tail that resembles a pig's tail. They are omnivorous and live in social groups that can range from a few individuals to several hundred.

While "Macaca nemestrina" may not have a direct medical definition, these monkeys have been used as models in biomedical research due to their close genetic relationship with humans. Some studies involving pig-tailed macaques have contributed to our understanding of various human diseases and conditions, such as infectious diseases, neurological disorders, and reproductive health. However, it is important to note that the use of animals in research remains a controversial topic, and ethical considerations must be taken into account when conducting such studies.

According to the American Academy of Periodontology, periodontal diseases are chronic inflammatory conditions that affect the tissues surrounding and supporting the teeth. These tissues include the gums, periodontal ligament, and alveolar bone. The primary cause of periodontal disease is bacterial plaque, a sticky film that constantly forms on our teeth.

There are two major stages of periodontal disease:

1. Gingivitis: This is the milder form of periodontal disease, characterized by inflammation of the gums (gingiva) without loss of attachment to the teeth. The gums may appear red, swollen, and bleed easily during brushing or flossing. At this stage, the damage can be reversed with proper dental care and improved oral hygiene.
2. Periodontitis: If left untreated, gingivitis can progress to periodontitis, a more severe form of periodontal disease. In periodontitis, the inflammation extends beyond the gums and affects the deeper periodontal tissues, leading to loss of bone support around the teeth. Pockets filled with infection-causing bacteria form between the teeth and gums, causing further damage and potential tooth loss if not treated promptly.

Risk factors for developing periodontal disease include poor oral hygiene, smoking or using smokeless tobacco, genetic predisposition, diabetes, hormonal changes (such as pregnancy or menopause), certain medications, and systemic diseases like AIDS or cancer. Regular dental check-ups and good oral hygiene practices are crucial for preventing periodontal disease and maintaining overall oral health.

Soft tissue neoplasms refer to abnormal growths or tumors that develop in the soft tissues of the body. Soft tissues include muscles, tendons, ligaments, fascia, nerves, blood vessels, fat, and synovial membranes (the thin layer of cells that line joints and tendons). Neoplasms can be benign (non-cancerous) or malignant (cancerous), and their behavior and potential for spread depend on the specific type of neoplasm.

Benign soft tissue neoplasms are typically slow-growing, well-circumscribed, and rarely spread to other parts of the body. They can often be removed surgically with a low risk of recurrence. Examples of benign soft tissue neoplasms include lipomas (fat tumors), schwannomas (nerve sheath tumors), and hemangiomas (blood vessel tumors).

Malignant soft tissue neoplasms, on the other hand, can grow rapidly, invade surrounding tissues, and may metastasize (spread) to distant parts of the body. They are often more difficult to treat than benign neoplasms and require a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. Examples of malignant soft tissue neoplasms include sarcomas, such as rhabdomyosarcoma (arising from skeletal muscle), leiomyosarcoma (arising from smooth muscle), and angiosarcoma (arising from blood vessels).

It is important to note that soft tissue neoplasms can occur in any part of the body, and their diagnosis and treatment require a thorough evaluation by a healthcare professional with expertise in this area.

Mediastinal diseases refer to a group of conditions that affect the mediastinum, which is the area in the chest separating the lungs and containing various vital structures such as the heart, esophagus, trachea, thymus gland, lymph nodes, blood vessels, and nerves. These diseases can be benign or malignant (cancerous) and may cause symptoms due to compression or invasion of surrounding tissues. Examples of mediastinal diseases include:

1. Mediastinal tumors: Abnormal growths in the mediastinum, which can be benign or malignant. Common types include thymomas, germ cell tumors, lymphomas, and neurogenic tumors.
2. Mediastinitis: Inflammation of the mediastinal tissues, often caused by infections, trauma, or complications from medical procedures.
3. Enlarged lymph nodes: Abnormal swelling of the lymph nodes in the mediastinum can be a sign of various conditions, including infections, cancer, and autoimmune disorders.
4. Mediastinal cysts: Fluid-filled sacs that develop in the mediastinum, which are usually benign but may cause symptoms due to compression or infection.
5. Aneurysms or dissections of the aorta: Abnormal weakening or tearing of the aortic wall within the mediastinum, which can lead to life-threatening complications if not treated promptly.
6. Esophageal diseases: Conditions affecting the esophagus, such as tumors, strictures, or motility disorders, may present with symptoms related to the mediastinum.
7. Thyroid disorders: Enlargement of the thyroid gland (goiter) can extend into the mediastinum and cause compression symptoms.
8. Hematomas or effusions: Accumulation of blood (hematoma) or fluid (effusion) in the mediastinal space due to trauma, surgery, or other underlying conditions.

Early diagnosis and appropriate treatment are crucial for managing mediastinal diseases and improving patient outcomes.

Thoracic neoplasms refer to abnormal growths or tumors that develop in the thorax, which is the area of the body that includes the chest and lungs. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant thoracic neoplasms are often referred to as lung cancer, but they can also include other types of cancer such as mesothelioma, thymoma, and esophageal cancer.

Thoracic neoplasms can cause various symptoms depending on their location and size. Common symptoms include coughing, chest pain, shortness of breath, hoarseness, and difficulty swallowing. Treatment options for thoracic neoplasms depend on the type, stage, and location of the tumor, as well as the patient's overall health. Treatment may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches.

High-energy shock waves are intense, short pulses of mechanical energy that can be used in medical treatments. They are created by rapidly accelerating and decelerating a substance, such as gas or liquid, to produce a compression wave that travels through a medium. When this compression wave encounters a boundary between tissues with different acoustic impedances, it reflects back and creates a shock wave with high-energy peaks.

In medical terms, high-energy shock waves are often used in the treatment of various conditions, such as kidney stones (lithotripsy), musculoskeletal disorders (extracorporeal shock wave therapy or ESWT), and wound healing. The high-energy peaks of the shock waves can cause cavitation, tissue fracture, and other biological effects that can help break up kidney stones, stimulate tissue regeneration, and improve blood flow to promote healing.

It is important to note that while high-energy shock waves have therapeutic benefits, they can also cause harm if not used properly. Therefore, it is essential to receive treatment from a qualified medical professional who has experience in administering shock wave therapy.

"Porphyromonas gingivalis" is a gram-negative, anaerobic, rod-shaped bacterium that is commonly found in the oral cavity and is associated with periodontal disease. It is a major pathogen in chronic periodontitis, which is a severe form of gum disease that can lead to destruction of the tissues supporting the teeth, including the gums, periodontal ligament, and alveolar bone.

The bacterium produces several virulence factors, such as proteases and endotoxins, which contribute to its pathogenicity. It has been shown to evade the host's immune response and cause tissue destruction through various mechanisms, including inducing the production of pro-inflammatory cytokines and matrix metalloproteinases.

P. gingivalis has also been linked to several systemic diseases, such as atherosclerosis, rheumatoid arthritis, and Alzheimer's disease, although the exact mechanisms of these associations are not fully understood. Effective oral hygiene practices, including regular brushing, flossing, and professional dental cleanings, can help prevent the overgrowth of P. gingivalis and reduce the risk of periodontal disease.

Retroperitoneal neoplasms refer to abnormal growths or tumors that develop in the retroperitoneal space. This is the area located behind the peritoneum, which is the membrane that lines the abdominal cavity and covers the abdominal organs. The retroperitoneal space contains several vital structures such as the kidneys, adrenal glands, pancreas, aorta, and lymphatic vessels.

Retroperitoneal neoplasms can be benign or malignant (cancerous). Malignant retroperitoneal neoplasms are often aggressive and can invade surrounding tissues and organs, leading to various complications. Common types of retroperitoneal neoplasms include lymphomas, sarcomas, and metastatic tumors from other primary sites. Symptoms may vary depending on the size and location of the tumor but can include abdominal or back pain, weight loss, and swelling in the legs. Diagnosis typically involves imaging studies such as CT scans or MRI, followed by a biopsy to determine the type and grade of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Maxillary sinus neoplasms refer to abnormal growths or tumors that develop in the maxillary sinuses, which are located in the upper part of your cheekbones, below your eyes. These growths can be benign (non-cancerous) or malignant (cancerous).

Benign neoplasms may include conditions such as an osteoma (a benign bone tumor), a papilloma (a benign growth of the lining of the sinus), or a fibrous dysplasia (a condition where bone is replaced by fibrous tissue).

Malignant neoplasms, on the other hand, can be primary (originating in the maxillary sinuses) or secondary (spreading to the maxillary sinuses from another site in the body). Common types of malignant tumors that arise in the maxillary sinus include squamous cell carcinoma, adenocarcinoma, and mucoepidermoid carcinoma.

Symptoms of maxillary sinus neoplasms may include nasal congestion, nosebleeds, facial pain or numbness, vision changes, and difficulty swallowing or speaking. Treatment options depend on the type, size, and location of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

A periodontal pocket is a pathological space or gap that develops between the tooth and the surrounding gum tissue (gingiva) as a result of periodontal disease. This condition is also known as a "periodontal depth" or "probing depth." It is measured in millimeters using a dental probe, and it indicates the level of attachment loss of the gingival tissue to the tooth.

In a healthy periodontium, the sulcus (the normal space between the tooth and gum) measures 1-3 mm in depth. However, when there is inflammation due to bacterial accumulation, the gums may become red, swollen, and bleed easily. As the disease progresses, the sulcus deepens, forming a periodontal pocket, which can extend deeper than 3 mm.

Periodontal pockets provide an environment that is conducive to the growth of harmful bacteria, leading to further tissue destruction and bone loss around the tooth. If left untreated, periodontal disease can result in loose teeth and eventually tooth loss. Regular dental check-ups and professional cleanings are essential for maintaining healthy gums and preventing periodontal pockets from developing or worsening.

Developmental bone diseases are a group of medical conditions that affect the growth and development of bones. These diseases are present at birth or develop during childhood and adolescence, when bones are growing rapidly. They can result from genetic mutations, hormonal imbalances, or environmental factors such as poor nutrition.

Some examples of developmental bone diseases include:

1. Osteogenesis imperfecta (OI): Also known as brittle bone disease, OI is a genetic disorder that affects the body's production of collagen, a protein necessary for healthy bones. People with OI have fragile bones that break easily and may also experience other symptoms such as blue sclerae (whites of the eyes), hearing loss, and joint laxity.
2. Achondroplasia: This is the most common form of dwarfism, caused by a genetic mutation that affects bone growth. People with achondroplasia have short limbs and a large head relative to their body size.
3. Rickets: A condition caused by vitamin D deficiency or an inability to absorb or use vitamin D properly. This leads to weak, soft bones that can bow or bend easily, particularly in children.
4. Fibrous dysplasia: A rare bone disorder where normal bone is replaced with fibrous tissue, leading to weakened bones and deformities.
5. Scoliosis: An abnormal curvature of the spine that can develop during childhood or adolescence. While not strictly a developmental bone disease, scoliosis can be caused by various underlying conditions such as cerebral palsy, muscular dystrophy, or spina bifida.

Treatment for developmental bone diseases varies depending on the specific condition and its severity. Treatment may include medication, physical therapy, bracing, or surgery to correct deformities and improve function. Regular follow-up with a healthcare provider is essential to monitor growth, manage symptoms, and prevent complications.

Epithelial attachment is a general term that refers to the point where epithelial cells, which are the cells that line the outer surfaces of organs and blood vessels, adhere or attach to an underlying structure. In the context of the mouth and teeth, epithelial attachment is often used to describe the connection between the gum tissue (gingiva) and the tooth surface.

In a healthy mouth, the gingival tissue fits tightly around each tooth, forming a protective seal that helps prevent bacteria and other harmful substances from entering the spaces between the teeth and gums. This tight seal is maintained by specialized epithelial cells called junctional epithelial cells, which form a barrier between the oral environment and the underlying connective tissue.

When the gingival tissue becomes inflamed due to factors such as poor oral hygiene or certain medical conditions, the epithelial attachment can become compromised, leading to a condition known as gingivitis. If left untreated, gingivitis can progress to periodontal disease, which is characterized by the destruction of the tissues that support the teeth, including the bone and connective tissue.

In summary, epithelial attachment refers to the point where epithelial cells adhere to an underlying structure, and in the context of oral health, it describes the connection between the gum tissue and the tooth surface.

Chronic periodontitis is a type of gum disease that is characterized by the inflammation and infection of the tissues surrounding and supporting the teeth. It is a slow-progressing condition that can lead to the destruction of the periodontal ligament and alveolar bone, which can result in loose teeth or tooth loss if left untreated.

Chronic periodontitis is caused by the buildup of dental plaque and calculus (tartar) on the teeth, which harbor bacteria that release toxins that irritate and inflame the gums. Over time, this chronic inflammation can lead to the destruction of the periodontal tissues, including the gingiva, periodontal ligament, and alveolar bone.

The signs and symptoms of chronic periodontitis include:

* Red, swollen, or tender gums
* Bleeding gums during brushing or flossing
* Persistent bad breath (halitosis)
* Receding gums (exposure of the tooth root)
* Loose teeth or changes in bite alignment
* Deep periodontal pockets (spaces between the teeth and gums)

Risk factors for chronic periodontitis include poor oral hygiene, smoking, diabetes, genetics, and certain medications. Treatment typically involves a thorough dental cleaning to remove plaque and calculus, followed by additional procedures such as scaling and root planing or surgery to eliminate infection and promote healing of the periodontal tissues. Good oral hygiene practices, regular dental checkups, and quitting smoking are essential for preventing chronic periodontitis and maintaining good oral health.

The periodontium is a complex structure in the oral cavity that surrounds and supports the teeth. It consists of four main components:
1. Gingiva (gums): The pink, soft tissue that covers the crown of the tooth and extends down to the neck of the tooth, where it meets the cementum.
2. Cementum: A specialized, calcified tissue that covers the root of the tooth and provides a surface for the periodontal ligament fibers to attach.
3. Periodontal ligament (PDL): A highly vascular and cell-rich connective tissue that attaches the cementum of the tooth root to the alveolar bone, allowing for tooth mobility and absorption of forces during chewing.
4. Alveolar bone: The portion of the jawbone that contains the sockets (alveoli) for the teeth. It is a spongy bone with a rich blood supply that responds to mechanical stresses from biting and chewing, undergoing remodeling throughout life.

Periodontal diseases, such as gingivitis and periodontitis, affect the health and integrity of the periodontium, leading to inflammation, bleeding, pocket formation, bone loss, and ultimately tooth loss if left untreated.

T-cell transcription factor 1 (TFH1), also known as TCF7, is a protein that plays a crucial role in the development and function of T cells, which are a type of white blood cell involved in immune response. TFH1 is a transcription factor, meaning it binds to specific regions of DNA and helps control the expression of genes involved in T cell activation, differentiation, and survival.

TFH1 is part of a family of transcription factors called basic helix-loop-helix proteins, which are characterized by a conserved region known as the bHLH domain. This domain allows TFH1 to bind to DNA and regulate gene expression. In T cells, TFH1 helps control the expression of genes involved in T cell activation and differentiation, including those that encode cytokine receptors and other transcription factors.

Mutations in the gene that encodes TFH1 (TCF7) have been associated with various immune disorders, including autoimmune diseases and primary immunodeficiencies. Additionally, recent research has suggested that TFH1 may play a role in cancer biology, as it has been shown to be upregulated in certain types of tumors and may contribute to tumor growth and progression.

Fibroblasts are specialized cells that play a critical role in the body's immune response and wound healing process. They are responsible for producing and maintaining the extracellular matrix (ECM), which is the non-cellular component present within all tissues and organs, providing structural support and biochemical signals for surrounding cells.

Fibroblasts produce various ECM proteins such as collagens, elastin, fibronectin, and laminins, forming a complex network of fibers that give tissues their strength and flexibility. They also help in the regulation of tissue homeostasis by controlling the turnover of ECM components through the process of remodeling.

In response to injury or infection, fibroblasts become activated and start to proliferate rapidly, migrating towards the site of damage. Here, they participate in the inflammatory response, releasing cytokines and chemokines that attract immune cells to the area. Additionally, they deposit new ECM components to help repair the damaged tissue and restore its functionality.

Dysregulation of fibroblast activity has been implicated in several pathological conditions, including fibrosis (excessive scarring), cancer (where they can contribute to tumor growth and progression), and autoimmune diseases (such as rheumatoid arthritis).

Gingivoplasty is a surgical procedure in dentistry that involves the reshaping or contouring of the gingiva (gums). This procedure is typically performed for aesthetic purposes, to improve the appearance of gums that are uneven or have an irregular shape. It can also be done to remove excess gum tissue that may be covering too much of a tooth, making it appear shorter than the other teeth.

Gingivoplasty is often recommended as a part of periodontal treatment to ensure the proper fit and function of dental restorations or to manage and prevent gum disease. The procedure involves removing and reshaping the gingival tissue to create a more aesthetically pleasing and healthy gum line.

It's important to note that while gingivoplasty can improve the appearance of the gums, it does not address any underlying issues related to gum disease or bone loss. Additional periodontal treatments may be necessary to address these concerns.

Foot diseases refer to various medical conditions that affect the foot, including its structures such as the bones, joints, muscles, tendons, ligaments, blood vessels, and nerves. These conditions can cause symptoms like pain, swelling, numbness, difficulty walking, and skin changes. Examples of foot diseases include:

1. Plantar fasciitis: inflammation of the band of tissue that connects the heel bone to the toes.
2. Bunions: a bony bump that forms on the joint at the base of the big toe.
3. Hammertoe: a deformity in which the toe is bent at the middle joint, resembling a hammer.
4. Diabetic foot: a group of conditions that can occur in people with diabetes, including nerve damage, poor circulation, and increased risk of infection.
5. Athlete's foot: a fungal infection that affects the skin between the toes and on the soles of the feet.
6. Ingrown toenails: a condition where the corner or side of a toenail grows into the flesh of the toe.
7. Gout: a type of arthritis that causes sudden, severe attacks of pain, swelling, redness, and tenderness in the joints, often starting with the big toe.
8. Foot ulcers: open sores or wounds that can occur on the feet, especially in people with diabetes or poor circulation.
9. Morton's neuroma: a thickening of the tissue around a nerve between the toes, causing pain and numbness.
10. Osteoarthritis: wear and tear of the joints, leading to pain, stiffness, and reduced mobility.

Foot diseases can affect people of all ages and backgrounds, and some may be prevented or managed with proper foot care, hygiene, and appropriate medical treatment.

Periodontal attachment loss (PAL) is a clinical measurement in dentistry that refers to the amount of connective tissue attachment between the tooth and its surrounding supportive structures (including the gingiva, periodontal ligament, and alveolar bone) that has been lost due to periodontal disease. It is typically expressed in millimeters and represents the distance from the cementoenamel junction (CEJ), which is the point where the tooth's crown meets the root, to the bottom of the periodontal pocket.

Periodontal pockets are formed when the gums detach from the tooth due to inflammation and infection caused by bacterial biofilms accumulating on the teeth. As the disease progresses, more and more of the supporting structures are destroyed, leading to increased pocket depths and attachment loss. This can eventually result in loose teeth and even tooth loss if left untreated.

Therefore, periodontal attachment loss is an important indicator of the severity and progression of periodontal disease, and its measurement helps dental professionals assess the effectiveness of treatment interventions and monitor disease status over time.

Dental plaque is a biofilm or mass of bacteria that accumulates on the surface of the teeth, restorative materials, and prosthetic devices such as dentures. It is initiated when bacterial colonizers attach to the smooth surfaces of teeth through van der Waals forces and specific molecular adhesion mechanisms.

The microorganisms within the dental plaque produce extracellular polysaccharides that help to stabilize and strengthen the biofilm, making it resistant to removal by simple brushing or rinsing. Over time, if not regularly removed through oral hygiene practices such as brushing and flossing, dental plaque can mineralize and harden into tartar or calculus.

The bacteria in dental plaque can cause tooth decay (dental caries) by metabolizing sugars and producing acid that demineralizes the tooth enamel. Additionally, certain types of bacteria in dental plaque can cause periodontal disease, an inflammation of the gums that can lead to tissue damage and bone loss around the teeth. Regular professional dental cleanings and good oral hygiene practices are essential for preventing the buildup of dental plaque and maintaining good oral health.

Human chromosome pair 2 consists of two rod-shaped structures present in the nucleus of each cell of the human body. Each member of the pair contains thousands of genes and other genetic material, encoded in the form of DNA molecules. Chromosomes are the physical carriers of inheritance, and human cells typically contain 23 pairs of chromosomes for a total of 46 chromosomes.

Chromosome pair 2 is one of the autosomal pairs, meaning that it is not a sex chromosome (X or Y). Each member of chromosome pair 2 is approximately 247 million base pairs in length and contains an estimated 1,000-1,300 genes. These genes play crucial roles in various biological processes, including development, metabolism, and response to environmental stimuli.

Abnormalities in chromosome pair 2 can lead to genetic disorders, such as cat-eye syndrome (CES), which is characterized by iris abnormalities, anal atresia, hearing loss, and intellectual disability. This disorder arises from the presence of an extra copy of a small region on chromosome 2, resulting in partial trisomy of this region. Other genetic conditions associated with chromosome pair 2 include proximal 2q13.3 microdeletion syndrome and Potocki-Lupski syndrome (PTLS).

Peptide receptors are a type of cell surface receptor that bind to peptide hormones and neurotransmitters. These receptors play crucial roles in various physiological processes, including regulation of appetite, pain perception, immune function, and cardiovascular homeostasis. Peptide receptors belong to the G protein-coupled receptor (GPCR) superfamily or the tyrosine kinase receptor family. Upon binding of a peptide ligand, these receptors activate intracellular signaling cascades that ultimately lead to changes in cell behavior and communication with other cells.

Peptide receptors can be classified into two main categories: metabotropic and ionotropic. Metabotropic peptide receptors are GPCRs, which activate intracellular signaling pathways through coupling with heterotrimeric G proteins. These receptors typically have seven transmembrane domains and undergo conformational changes upon ligand binding, leading to the activation of downstream effectors such as adenylyl cyclase, phospholipase C, or ion channels.

Ionotropic peptide receptors are ligand-gated ion channels that directly modulate ion fluxes across the cell membrane upon ligand binding. These receptors contain four or five subunits arranged around a central pore and undergo conformational changes to allow ion flow through the channel.

Examples of peptide receptors include:

1. Opioid receptors (μ, δ, κ) - bind endogenous opioid peptides such as enkephalins, endorphins, and dynorphins to modulate pain perception and reward processing.
2. Somatostatin receptors (SSTR1-5) - bind somatostatin and cortistatin to regulate hormone secretion, cell proliferation, and angiogenesis.
3. Neuropeptide Y receptors (Y1-Y5) - bind neuropeptide Y to modulate feeding behavior, energy metabolism, and cardiovascular function.
4. Calcitonin gene-related peptide receptor (CGRP-R) - binds calcitonin gene-related peptide to mediate vasodilation and neurogenic inflammation.
5. Bradykinin B2 receptor (B2R) - binds bradykinin to induce pain, inflammation, and vasodilation.
6. Vasoactive intestinal polypeptide receptors (VPAC1, VPAC2) - bind vasoactive intestinal peptide to regulate neurotransmission, hormone secretion, and smooth muscle contraction.
7. Oxytocin receptor (OXTR) - binds oxytocin to mediate social bonding, maternal behavior, and uterine contractions during childbirth.
8. Angiotensin II type 1 receptor (AT1R) - binds angiotensin II to regulate blood pressure, fluid balance, and cell growth.

Immunohistochemistry (IHC) is a technique used in pathology and laboratory medicine to identify specific proteins or antigens in tissue sections. It combines the principles of immunology and histology to detect the presence and location of these target molecules within cells and tissues. This technique utilizes antibodies that are specific to the protein or antigen of interest, which are then tagged with a detection system such as a chromogen or fluorophore. The stained tissue sections can be examined under a microscope, allowing for the visualization and analysis of the distribution and expression patterns of the target molecule in the context of the tissue architecture. Immunohistochemistry is widely used in diagnostic pathology to help identify various diseases, including cancer, infectious diseases, and immune-mediated disorders.

Gingival retraction techniques are clinical procedures used in dentistry to temporarily retract the gingiva (gums) and expose the teeth's crown surfaces, especially the portion that is located below the gumline, known as the cementoenamel junction (CEJ), for a more precise impression making. This procedure is essential during the fabrication of dental restorations such as crowns, bridges, and dentures to ensure a proper fit and avoid future problems like recurrent decay or periodontal disease.

There are two main categories of gingival retraction techniques: mechanical and chemical methods. Mechanical methods involve the use of specific instruments, such as gingival retraction cords or plastic retraction devices, to physically displace the gum tissue from the tooth's preparation margin. In contrast, chemical methods rely on solutions containing astringents (like aluminum chloride or ferric sulfate) that cause the gingival tissues to contract and retract.

In some cases, a combination of both mechanical and chemical techniques may be employed for optimal retraction and hemostasis control. The choice of technique depends on factors like the patient's oral condition, the type and complexity of restoration being made, and the clinician's preference.

Alveolar bone loss refers to the breakdown and resorption of the alveolar process of the jawbone, which is the part of the jaw that contains the sockets of the teeth. This type of bone loss is often caused by periodontal disease, a chronic inflammation of the gums and surrounding tissues that can lead to the destruction of the structures that support the teeth.

In advanced stages of periodontal disease, the alveolar bone can become severely damaged or destroyed, leading to tooth loss. Alveolar bone loss can also occur as a result of other conditions, such as osteoporosis, trauma, or tumors. Dental X-rays and other imaging techniques are often used to diagnose and monitor alveolar bone loss. Treatment may include deep cleaning of the teeth and gums, medications, surgery, or tooth extraction in severe cases.

"Fusobacterium nucleatum" is a gram-negative, anaerobic, rod-shaped bacterium that is commonly found in the oral cavity and plays a significant role in periodontal disease. It has also been implicated in various extraintestinal infections, including septicemia, brain abscesses, and lung and liver infections. This bacterium is known to have a variety of virulence factors that contribute to its pathogenicity, such as the ability to adhere to and invade host cells, produce biofilms, and evade the immune response. It has been linked to several systemic diseases, including colorectal cancer, where it may promote tumor growth and progression through various mechanisms.

Root planing is a dental procedure that involves the cleaning and smoothing of the root surfaces of teeth. It is typically performed as a part of periodontal therapy to treat and manage gum disease. The goal of root planing is to remove tartar, calculus, and bacterial toxins from the roots of teeth, which helps to promote the reattachment of the gums to the teeth and prevent further progression of periodontal disease. This procedure is usually performed under local anesthesia and may require multiple appointments depending on the severity of the case.

Prevotella intermedia is a gram-negative, anaerobic, rod-shaped bacterium that is commonly found in the oral cavity, upper respiratory tract, and gastrointestinal tract. It is a normal resident of the human microbiota but can also be an opportunistic pathogen, causing various types of infections such as periodontitis, endocarditis, and brain abscesses. P. intermedia has been associated with several diseases, including respiratory tract infections, bacteremia, and joint infections. It is often found in mixed infections with other anaerobic bacteria. Proper identification of this organism is important for the selection of appropriate antimicrobial therapy.

Dental photography is a type of clinical photography that focuses on documenting the condition and treatment of teeth and oral structures. It involves using specialized cameras, lenses, and lighting to capture high-quality images of the mouth and related areas. These images can be used for diagnostic purposes, patient education, treatment planning, communication with other dental professionals, and monitoring progress over time. Dental photography may include various types of shots, such as extraoral (outside the mouth) and intraoral (inside the mouth) views, close-ups of individual teeth or restorations, and full-face portraits. It requires a strong understanding of dental anatomy, lighting techniques, and image composition to produce accurate and informative images.

Proto-oncogene proteins c-kit, also known as CD117 or stem cell factor receptor, are transmembrane receptor tyrosine kinases that play crucial roles in various biological processes, including cell survival, proliferation, differentiation, and migration. They are encoded by the c-KIT gene located on human chromosome 4q12.

These proteins consist of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. The binding of their ligand, stem cell factor (SCF), leads to receptor dimerization, autophosphorylation, and activation of several downstream signaling pathways such as PI3K/AKT, MAPK/ERK, and JAK/STAT.

Abnormal activation or mutation of c-kit proto-oncogene proteins has been implicated in the development and progression of various malignancies, including gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML), mast cell diseases, and melanoma. Targeted therapies against c-kit, such as imatinib mesylate (Gleevec), have shown promising results in the treatment of these malignancies.

I must clarify that the term "pedigree" is not typically used in medical definitions. Instead, it is often employed in genetics and breeding, where it refers to the recorded ancestry of an individual or a family, tracing the inheritance of specific traits or diseases. In human genetics, a pedigree can help illustrate the pattern of genetic inheritance in families over multiple generations. However, it is not a medical term with a specific clinical definition.

Local neoplasm recurrence is the return or regrowth of a tumor in the same location where it was originally removed or treated. This means that cancer cells have survived the initial treatment and started to grow again in the same area. It's essential to monitor and detect any local recurrence as early as possible, as it can affect the prognosis and may require additional treatment.

'Aggregatibacter actinomycetemcomitans' is a gram-negative, rod-shaped bacterium that belongs to the family Pasteurellaceae. It is facultatively anaerobic, meaning it can grow in both the presence and absence of oxygen. This bacterium is commonly found as part of the oral microbiota in humans and is associated with periodontal diseases such as localized aggressive periodontitis. Additionally, it has been implicated in various extraoral infections, including endocarditis, meningitis, and septicemia, particularly in individuals with underlying medical conditions. The bacterium's virulence factors include leukotoxin, cytolethal distending toxin, and adhesins, which contribute to its pathogenicity.

Aggressive periodontitis is a severe form of periodontal disease that affects the tissues surrounding and supporting the teeth, including the gums, periodontal ligament, and alveolar bone. It is characterized by rapid destruction of the periodontal tissues and can result in significant tooth loss if left untreated.

Aggressive periodontitis typically affects younger individuals, often before the age of 30, and can progress rapidly, even in the absence of obvious dental plaque or calculus accumulation. It is often associated with a genetic predisposition and may cluster in families.

The disease is classified as localized or generalized based on the distribution of affected sites. Localized aggressive periodontitis typically affects no more than two teeth next to each other, while generalized aggressive periodontitis involves at least three or four teeth in different areas of the mouth.

In addition to genetic factors, other risk factors for aggressive periodontitis include smoking, diabetes, and hormonal changes. Treatment typically involves a combination of thorough dental cleanings, antibiotics, and sometimes surgical intervention to remove damaged tissue and promote healing. Regular maintenance care is essential to prevent recurrence and further progression of the disease.

Dental scaling is a professional dental cleaning procedure that involves the removal of plaque, tartar (calculus), and stains from the tooth surfaces. This is typically performed by a dentist or dental hygienist using specialized instruments called scalers and curettes. The procedure helps to prevent gum disease and tooth decay by removing bacterial deposits that can cause inflammation and infection of the gums. Dental scaling may be recommended as part of a routine dental check-up or if there are signs of periodontal disease, such as red, swollen, or bleeding gums. In some cases, local anesthesia may be used to numb the area and make the procedure more comfortable for the patient.

Oral hygiene is the practice of keeping the mouth and teeth clean to prevent dental issues such as cavities, gum disease, bad breath, and other oral health problems. It involves regular brushing, flossing, and using mouthwash to remove plaque and food particles that can lead to tooth decay and gum disease. Regular dental check-ups and cleanings are also an essential part of maintaining good oral hygiene. Poor oral hygiene can lead to a range of health problems, including heart disease, diabetes, and respiratory infections, so it is important to prioritize oral health as part of overall health and wellbeing.

X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.

The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.

CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.

In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.

CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.

In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Treponema denticola is a gram-negative, spiral-shaped bacterium that belongs to the genus Treponema. It is commonly found in the oral cavity and is associated with periodontal diseases such as chronic periodontitis. T. denticola is one of the "red complex" bacteria, which also includes Porphyromonas gingivalis and Tannerella forsythia, that are strongly associated with periodontal disease. These bacteria form a complex biofilm in the subgingival area and contribute to the breakdown of the periodontal tissues, leading to pocket formation, bone loss, and ultimately tooth loss if left untreated.

T. denticola has several virulence factors, including lipopolysaccharides (LPS), proteases, fimbriae, and endotoxins, that allow it to evade the host's immune system and cause tissue damage. It can also modulate the host's immune response, leading to a chronic inflammatory state that contributes to the progression of periodontal disease.

In addition to its role in periodontal disease, T. denticola has been linked to several systemic diseases, including cardiovascular disease, diabetes, and rheumatoid arthritis. However, more research is needed to fully understand the relationship between T. denticola and these conditions.

The mouth mucosa refers to the mucous membrane that lines the inside of the mouth, also known as the oral mucosa. It covers the tongue, gums, inner cheeks, palate, and floor of the mouth. This moist tissue is made up of epithelial cells, connective tissue, blood vessels, and nerve endings. Its functions include protecting the underlying tissues from physical trauma, chemical irritation, and microbial infections; aiding in food digestion by producing enzymes; and providing sensory information about taste, temperature, and texture.

A fatal outcome is a term used in medical context to describe a situation where a disease, injury, or illness results in the death of an individual. It is the most severe and unfortunate possible outcome of any medical condition, and is often used as a measure of the severity and prognosis of various diseases and injuries. In clinical trials and research, fatal outcome may be used as an endpoint to evaluate the effectiveness and safety of different treatments or interventions.

Cytoskeletal proteins are a type of structural proteins that form the cytoskeleton, which is the internal framework of cells. The cytoskeleton provides shape, support, and structure to the cell, and plays important roles in cell division, intracellular transport, and maintenance of cell shape and integrity.

There are three main types of cytoskeletal proteins: actin filaments, intermediate filaments, and microtubules. Actin filaments are thin, rod-like structures that are involved in muscle contraction, cell motility, and cell division. Intermediate filaments are thicker than actin filaments and provide structural support to the cell. Microtubules are hollow tubes that are involved in intracellular transport, cell division, and maintenance of cell shape.

Cytoskeletal proteins are composed of different subunits that polymerize to form filamentous structures. These proteins can be dynamically assembled and disassembled, allowing cells to change their shape and move. Mutations in cytoskeletal proteins have been linked to various human diseases, including cancer, neurological disorders, and muscular dystrophies.

A biopsy is a medical procedure in which a small sample of tissue is taken from the body to be examined under a microscope for the presence of disease. This can help doctors diagnose and monitor various medical conditions, such as cancer, infections, or autoimmune disorders. The type of biopsy performed will depend on the location and nature of the suspected condition. Some common types of biopsies include:

1. Incisional biopsy: In this procedure, a surgeon removes a piece of tissue from an abnormal area using a scalpel or other surgical instrument. This type of biopsy is often used when the lesion is too large to be removed entirely during the initial biopsy.

2. Excisional biopsy: An excisional biopsy involves removing the entire abnormal area, along with a margin of healthy tissue surrounding it. This technique is typically employed for smaller lesions or when cancer is suspected.

3. Needle biopsy: A needle biopsy uses a thin, hollow needle to extract cells or fluid from the body. There are two main types of needle biopsies: fine-needle aspiration (FNA) and core needle biopsy. FNA extracts loose cells, while a core needle biopsy removes a small piece of tissue.

4. Punch biopsy: In a punch biopsy, a round, sharp tool is used to remove a small cylindrical sample of skin tissue. This type of biopsy is often used for evaluating rashes or other skin abnormalities.

5. Shave biopsy: During a shave biopsy, a thin slice of tissue is removed from the surface of the skin using a sharp razor-like instrument. This technique is typically used for superficial lesions or growths on the skin.

After the biopsy sample has been collected, it is sent to a laboratory where a pathologist will examine the tissue under a microscope and provide a diagnosis based on their findings. The results of the biopsy can help guide further treatment decisions and determine the best course of action for managing the patient's condition.

Bacteroidaceae is a family of gram-negative, anaerobic bacteria that are commonly found in the human gastrointestinal tract. Infections caused by Bacteroidaceae are relatively rare, but can occur in cases of severe trauma, surgery, or compromised immune systems. These infections may include bacteremia (bacteria in the blood), abscesses, and wound infections. Treatment typically involves the use of antibiotics that are effective against anaerobic bacteria. It is important to note that proper identification of the specific species causing the infection is necessary for appropriate treatment, as different species within Bacteroidaceae may have different susceptibilities to various antibiotics.

Dental devices for home care are products designed for use by individuals or their caregivers in a home setting to maintain oral hygiene, manage dental health issues, and promote overall oral health. These devices can include:

1. Toothbrushes: Manual, electric, or battery-operated toothbrushes used to clean teeth and remove plaque and food debris.
2. Dental floss: A thin string used to remove food particles and plaque from between the teeth and under the gum line.
3. Interdental brushes: Small brushes designed to clean between the teeth and around dental appliances, such as braces or implants.
4. Water flossers/oral irrigators: Devices that use a stream of water to remove food particles and plaque from between the teeth and under the gum line.
5. Tongue scrapers: Tools used to clean the tongue's surface, removing bacteria and reducing bad breath.
6. Rubber tips/gum stimulators: Devices used to massage and stimulate the gums, promoting blood circulation and helping to maintain gum health.
7. Dental picks/sticks: Pointed tools used to remove food particles and plaque from between the teeth and under the gum line.
8. Mouthguards: Protective devices worn over the teeth to prevent damage from grinding, clenching, or sports-related injuries.
9. Night guards: Similar to mouthguards, these are designed to protect the teeth from damage caused by nighttime teeth grinding (bruxism).
10. Dental retainers: Devices used to maintain the alignment of teeth after orthodontic treatment.
11. Whitening trays and strips: At-home products used to whiten teeth by applying a bleaching agent to the tooth surface.
12. Fluoride mouth rinses: Anticavity rinses containing fluoride, which help strengthen tooth enamel and prevent decay.
13. Oral pain relievers: Topical gels or creams used to alleviate oral pain, such as canker sores or denture irritation.

Proper use of these dental devices, along with regular dental check-ups and professional cleanings, can help maintain good oral health and prevent dental issues.

Head and neck neoplasms refer to abnormal growths or tumors in the head and neck region, which can be benign (non-cancerous) or malignant (cancerous). These tumors can develop in various sites, including the oral cavity, nasopharynx, oropharynx, larynx, hypopharynx, paranasal sinuses, salivary glands, and thyroid gland.

Benign neoplasms are slow-growing and generally do not spread to other parts of the body. However, they can still cause problems if they grow large enough to press on surrounding tissues or structures. Malignant neoplasms, on the other hand, can invade nearby tissues and organs and may also metastasize (spread) to other parts of the body.

Head and neck neoplasms can have various symptoms depending on their location and size. Common symptoms include difficulty swallowing, speaking, or breathing; pain in the mouth, throat, or ears; persistent coughing or hoarseness; and swelling or lumps in the neck or face. Early detection and treatment of head and neck neoplasms are crucial for improving outcomes and reducing the risk of complications.

The periodontal ligament, also known as the "PDL," is the soft tissue that connects the tooth root to the alveolar bone within the dental alveolus (socket). It consists of collagen fibers organized into groups called principal fibers and accessory fibers. These fibers are embedded into both the cementum of the tooth root and the alveolar bone, providing shock absorption during biting and chewing forces, allowing for slight tooth movement, and maintaining the tooth in its position within the socket.

The periodontal ligament plays a crucial role in the health and maintenance of the periodontium, which includes the gingiva (gums), cementum, alveolar bone, and the periodontal ligament itself. Inflammation or infection of the periodontal ligament can lead to periodontal disease, potentially causing tooth loss if not treated promptly and appropriately.

Tooth movement, in a dental and orthodontic context, refers to the physical change in position or alignment of one or more teeth within the jaw bone as a result of controlled forces applied through various orthodontic appliances such as braces, aligners, or other orthodontic devices. The purposeful manipulation of these forces encourages the periodontal ligament (the tissue that connects the tooth to the bone) to remodel, allowing the tooth to move gradually over time into the desired position. This process is crucial in achieving proper bite alignment, correcting malocclusions, and enhancing overall oral function and aesthetics.

... (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival ... S. L. Singer, J. Goldblatt, L. A. Hallam, and J. C. Winters, "Hereditary gingival fibromatosis with a recessive mode of ... K. B. Butchi, K. Pavankumar, B. R. Anuradha, and N. Arora, "Hereditary gingival fibromatosis-a case report and management using ... View at Scopus R. J. Jorgenson and M. E. Cocker, "Variation in the inheritance and expression of gingival fibromatosis", ...
... is a cutaneous condition characterized by dark terminal hairs on the peripheral face ...
ACVR1 Fibromatosis, gingival; 135300; SOS1 Fibromatosis, gingival, 2; 135300; GINGF2 Fibromatosis, juvenile hyaline; 228600; ...
Hereditary gingival fibromatosis". The Journal of the Michigan Dental Association. 94 (12): 40-3. PMID 23346694. "Gingival ... Gingival enlargement is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival ... This type of gingival enlargement is sometimes termed "drug induced gingival enlargement" or "drug influenced gingival ... The terms gingival hyperplasia and gingival hypertrophy have been used to describe this topic in the past. These are not ...
"Orphanet: Gingival fibromatosis progressive deafness syndrome". www.orpha.net. Retrieved 2021-09-13. "Jones syndrome , Genetic ... Jones syndrome is an extremely rare disorder characterized by gingival fibromatosis and sensorineural hearing loss. The ...
Coletta, RD, Graner, E. (2007). "Hereditary gingival fibromatosis: A systematic review". J. Periodontol. 77 (5): 753-64. doi: ... Where a patient presents with an unsightly gummy smile due to too much gingival coverage of tooth crown, especially the upper ... Laser gingivectomy is a dental procedure that recontours or scalpels the gingival tissue to improve long term dental health or ... "Combined treatment approach of gingivectomy and CO2 laser for cyclosporine-induced gingival overgrowth". www.quintpub.com. ...
Gingival fibromatosis is usually present at birth or appears shortly thereafter. Both males and females are equally affected. ... Clinical features include gingival fibromatosis, hypoplasia of the distal phalanges, nail dysplasia, joint hypermobility, and ... Fibromatosis gingival, with abnormal fingers, fingernails, nose and ears, and splenomegaly at NIH's Office of Rare Diseases ...
Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan ... September 2000). "Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on ... April 2002). "A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1". American Journal of Human Genetics. ...
Dominant mutant alleles of SOS1 have recently been found to cause Noonan syndrome and hereditary gingival fibromatosis type 1. ... "A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1". Am. J. Hum. Genet. 70 (4): 943-54. doi:10.1086/ ...
Clinical features include extreme pain at minimal handling in a newborn, gingival hypertrophy, subcutaneous nodules, painful ... Juvenile hyaline fibromatosis (also known as fibromatosis hyalinica multiplex juvenilis and Murray-Puretic-Drescher syndrome) ... "Orphanet: Juvenile hyaline fibromatosis". www.orpha.net. Retrieved 28 April 2019. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo ... The World Health Organization in 2020 reclassified the papules and nodules that occur in juvenile hyaline fibromatosis as one ...
Hereditary gingival fibromatosis is the main example of a genetic disease causing gingival lesions. There is fibrous ... Specifically, hereditary gingival fibromatosis is known to cause non-plaque-induced gingival lesions. However, sometimes, there ... but from other gingival diseases caused by bacterial, viral, fungal, or genetic sources. Although this gingival disease is less ... These are far less common than plaque-induced gingival lesions. Non-plaque-induced gingival disease is an inflammation of the ...
... gingival neoplasms MeSH C07.465.714.258.428 - gingival overgrowth MeSH C07.465.714.258.428.200 - fibromatosis, gingival MeSH ... fibromatosis, gingival MeSH C07.465.525.480 - macrostomia MeSH C07.465.525.520 - microstomia MeSH C07.465.525.955 - ... fibromatosis, gingival MeSH C07.650.525.480 - macrostomia MeSH C07.650.525.520 - microstomia MeSH C07.650.525.955 - ... gingival recession MeSH C07.465.714.258.480 - gingivitis MeSH C07.465.714.258.480.360 - gingival pocket MeSH C07.465.714.258. ...
Generalized trichoepithelioma Giant axonal neuropathy with curly hair Gingival fibromatosis with hypertrichosis Haber syndrome ... Gingival fibroma Gingival hypertrophy Hairy leukoplakia (oral hairy leukoplakia) Intraoral dental sinus Linea alba Leukoplakia ... Juvenile hyaline fibromatosis (fibromatosis hyalinica multiplex juvenilis, Murray-Puretic-Drescher syndrome) Kaposiform ... congenital generalized fibromatosis, congenital multicentric fibromatosis) Infantile systemic hyalinosis (juvenile systemic ...
... characterized by an overgrowth of the facial and cranial bones Hereditary gingival fibromatosis a rare condition of gingival ... in which there is an abnormal increase in the size of the body or a body part Small intestinal bacterial overgrowth Gingival ...
... motility and morphogenic factor Hereditary gingival fibromatosis, a rare condition of gingival overgrowth Human Growth ...
... as well a potential monoclonal antibody against hereditary gingival fibromatosis (HGF) and C-Met. Hydroxytyrosol Oleuropein ...
AV malformation syndrome Autoimmune lymphoproliferative syndrome Cardiofaciocutaneous syndrome Hereditary gingival fibromatosis ...
... fibromatosis, gingival MeSH C16.131.850.525.480 - macrostomia MeSH C16.131.850.525.520 - microstomia MeSH C16.131.850.525.955 ...
... impacted posterior teeth with hyperplastic pericoronal follicles gingival fibromatosis ectopic calcifications on gingival and ...
... syndrome Gilles de la Tourette's syndrome Gingival fibromatosis dominant Gingival fibromatosis facial dysmorphism Gingival ...
Fibrolipomatosis Fibroma Fibromatosis gingival hypertrichosis Fibromatosis multiple non ossifying Fibromatosis Fibromuscular ...
... gingival fibromatosis and severe intellectual disability and physical retardation.: 867-8 It was characterized in 1967. ...
Tentative evidence supports the use of verapamil topically to treat plantar fibromatosis. Verapamil use in people with recent ... Along with other calcium channel blockers, verapamil is known to induce gingival enlargement. Acute overdose is often ... Steele RM, Schuna AA, Schreiber RT (April 1994). "Calcium antagonist-induced gingival hyperplasia". Annals of Internal Medicine ... and management of plantar fibromatosis". Orthopedic Research and Reviews. 11: 1-7. doi:10.2147/ORR.S154289. PMC 6367723. PMID ...
Another cause of gingival enlargement would be a hereditary condition known as gingival fibromatosis. The extensive overgrowth ... creating a favourable environment for gingival healing and restoration of a physiologic gingival contour. The procedure may ... to achieve an aesthetically pleasing gingival architecture blending in harmoniously the gingival contours of the maxillary ... In cases of gingival enlargement induced by drugs, surgical treatment through a gingivectomy proved to be effective with most ...
... fibromatosis, abdominal MeSH C04.557.450.565.590.340.410 - fibromatosis, aggressive MeSH C04.557.450.565.590.350 - fibrosarcoma ... gingival neoplasms MeSH C04.588.443.591.545 - leukoplakia, oral MeSH C04.588.443.591.545.500 - leukoplakia, hairy MeSH C04.588. ...
Hereditary gingival fibromatosis (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival ... S. L. Singer, J. Goldblatt, L. A. Hallam, and J. C. Winters, "Hereditary gingival fibromatosis with a recessive mode of ... K. B. Butchi, K. Pavankumar, B. R. Anuradha, and N. Arora, "Hereditary gingival fibromatosis-a case report and management using ... View at Scopus R. J. Jorgenson and M. E. Cocker, "Variation in the inheritance and expression of gingival fibromatosis", ...
... alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia ... ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR ... binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. Furthermore, a ... is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. ...
SUASSUNA, Thalles Moreira et al. Extensive Idiopathic Gingival Fibromatosis: A Case Report. Rev. cir. traumatol. buco-maxilo- ... The Gingival Fibromatosis (GF) is described as a rare oral condition, clinically manifested by a slow, progressive, diffuse, ... This paper proposes a review of the clinical features, diagnosis and treatment of gingival fibromatosis and reports a severe ... and benign growth of gingival tissues. This condition can manifest itself in isolation, in combination with other systemic ...
Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. In: Nature ... Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. Nature ... Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. / Tommiska, ... title = "Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis", ...
Gingival fibromatosis with hypertrichosis syndrome: Case series of rare syndrome. Indian J Dent Res. 2017 Jul-Aug. 28 (4):457- ... Idiopathic gingival fibromatosis. J Indian Soc Periodontol. 2015 Nov-Dec. 19 (6):698-700. [QxMD MEDLINE Link]. ... Gingival fibromatosis deserves separate consideration. It may be hereditary, idiopathic, or drug induced. The hereditary and ... The hereditary form may also manifest as a component of a larger complex syndrome (eg, gingival fibromatosis with ...
Age Gender and Site Effect on Immunohistochemical Expression of TGF-β1 and IFN-γ in Hereditary Gingival Fibromatosis ...
... phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF ... Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) ... Activated KCNQ1 channel promotes fibrogenic response in hereditary gingival fibromatosis via clustering and activation of Ras.在 ... Activated KCNQ1 channel promotes fibrogenic response in hereditary gingival fibromatosis via clustering and activation of Ras. ...
Gingival Fibromatosis with Distinctive Facies Gitelman syndrome GLOBAL DEVELOPMENTAL DELAY, ABSENT OR HYPOPLASTIC CORPUS ...
... significance of electron microscopic examination of gingiva in cases of Hunter syndrome and hereditary gingival fibromatosis.. ... significance of electron microscopic examination of gingiva in cases of Hunter syndrome and hereditary gingival fibromatosis. ...
Gene expression profiling and bioinformatics analysis of hereditary gingival fibromatosis. Biomed. Rep. 8, 133-137. doi: ...
4. REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis.. Bayram Y, White JJ, Elcioglu N, Cho MT, Zadeh ...
Gingival fibromatosis with hypertrichosis syndrome: Case series of rare syndrome. Indian J Dent Res. 2017 Jul-Aug. 28 (4):457- ... Idiopathic gingival fibromatosis. J Indian Soc Periodontol. 2015 Nov-Dec. 19 (6):698-700. [QxMD MEDLINE Link]. ... Gingival fibromatosis deserves separate consideration. It may be hereditary, idiopathic, or drug induced. The hereditary and ... The hereditary form may also manifest as a component of a larger complex syndrome (eg, gingival fibromatosis with ...
Two family members with partial hypopituitarism and gingival fibromatosis caused by a missense mutation in KCNQ1. A Sabbe , ... The occurrence of childhood GHD in association with gingival fibromatosis led to the identification of two autosomal dominant ...
Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis. ... Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture. Comp Biochem ...
Dominant mutant alleles of SOS1 have recently been found to cause Noonan syndrome[3] and Hereditary Gingival Fibromatosis type ...
Coyac B, Forestier JP, Kerner S, Mora F, Chaussain C, Bouchard P. Hereditary Gingival Fibromatosis: Clinical Management and In ...
N. H. Wood, C. Anagnostopoulos, R. Meyerov, J. Lemmer, and L. Feller, "Idiopathic gingival fibromatosis: a review of the ... Secondary retention of permanent molars occurs after the molar has penetrated the gingival [53]. The aetiology is not fully ...
O Gingival bleeding,O Gingival calcification,O Gingival cleft,O Gingival fibromatosis,O Gingival hyperkeratosis,O Gingival ... O Inclusion body fibromatosis,O Incomitant strabismus,O Incomplete breech presentation,O Incomplete cleft of the upper lip,O ... overgrowth,O Gingival recession,O Gingivitis,O Glabellar hemangioma,O Glabellar reflex,O Glandular cell neoplasm,O Glandular ...
Hereditary gingival fibromatosis: a case report.. Baptista, Isabel Poiares. J Clin Periodontol ; 29(9): 871-4, 2002 Sep. ...
Familial Hereditary Gingival Fibromatosis: A Rare Case Report DÜNDAR S., USLU M. Ö., TOY V. E., ELTAS A. ...
Martelli Junior, H., Lemos, D.P., Silva, C.O., Graner, E. & Coletta, R.D. (2005). Hereditary gingival fibromatosis: report of a ...
Juvenile hyaline fibromatosis. Juvenile hyaline fibromatosis is an autosomal recessive disorder with skin lesions that consist ... Krasuska-Sławińska E, Polnik D, Rokicki D, Koeber B. Treatment of Massive Labial and Gingival Hypertrophy in a Patient With ... Juvenile hyaline fibromatosis: two new patients and review of the literature. Am J Med Genet. 1987 Jan. 26(1):123-31. [QxMD ... 25, 26, 27] Infantile systemic hyalinosis has overlapping features with juvenile hyaline fibromatosis and must also be ...
Gingival fibromatosis, 1 From NCATS Genetic and Rare Diseases Information Center. * Gingival fibromatosis, 2 From NCATS Genetic ... Gingival fibromatosis, 3 From NCATS Genetic and Rare Diseases Information Center. * Gingival fibromatosis, 4 From NCATS Genetic ... Gingival fibromatosis with distinctive facies From NCATS Genetic and Rare Diseases Information Center ... Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis. Jianfan Chen, et al. ...
Gingival fibromatosis. MedGen UID: 42017. •Concept ID: C0016049. •. Finding. The presence of fibrosis of the gingiva. ...
Gingival fibromatosis; Gingival enlargement; Idiopathic; Congenital 1 * Heavy mandibular labial frenum ; Frenectomy ; Apically ...
Hereditary gingival fibromatosis (FGH). Hereditary gingival fibromatosis consists of an increase in the volume of the gingiva ( ... gingival alterations of genetic origin or hereditary gingival fibromatosis. ... 3. Drug-related Gingival Diseases. Among them, we can mention Lichenoid Reactions and Gingival Hyperplasia. ... gingival disorders related to viral infections (mainly HIV and the human Herpes Virus (HHV) family); gingival alterations ...
Idiopathic gingival fibromatosis. J Indian Soc Periodontol. 2015 Nov-Dec. 19 (6):698-700. [QxMD MEDLINE Link]. ... Gingival fibromatosis deserves separate consideration. It may be hereditary, idiopathic, or drug induced. The hereditary and ... The hereditary form may also manifest as a component of a larger complex syndrome (eg, gingival fibromatosis with ... Gawron K, Łazarz-Bartyzel K, Potempa J, Chomyszyn-Gajewska M. Gingival fibromatosis: clinical, molecular and therapeutic issues ...
  • Hereditary gingival fibromatosis (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival overgrowth. (wikipedia.org)
  • Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. (nature.com)
  • Hereditary gingival fibromatosis (HGF) is an inherited disease characterized by fibrous overgrowth with pathological, nonhemorrhagic, diffuse or focal, slowly progressive hyperplasia of the gingival tissue, resulting in fibromatous hyperplasia of the gingival tissue. (nature.com)
  • BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). (shengsci.com)
  • The aim of the present study was to explore the pathogenic role of aberrantly activated potassium channel in Hereditary Gingival Fibromatosis (HGF). (shengsci.com)
  • The significance of electron microscopic examination of gingiva in cases of Hunter syndrome and hereditary gingival fibromatosis. (nel.edu)
  • Straka M, Danisovic L, Bzduch V, Polak S, Varga I. The significance of electron microscopic examination of gingiva in cases of Hunter syndrome and hereditary gingival fibromatosis. (nel.edu)
  • Dominant mutant alleles of SOS1 have recently been found to cause Noonan syndrome [3] and Hereditary Gingival Fibromatosis type 1 [4] . (bionity.com)
  • Coyac B, Forestier JP, Kerner S, Mora F, Chaussain C, Bouchard P. Hereditary Gingival Fibromatosis: Clinical Management and In Vitro Study - a case report.EuroPerio8, London 2015. (llu.edu)
  • Hereditary gingival fibromatosis: report of a five-generation family using cellular proliferation analysis. (bvsalud.org)
  • gingival alterations related to blood dyscrasias, with leukemia being the central blood disorder with gingival repercussion and, finally, gingival alterations of genetic origin or hereditary gingival fibromatosis. (cidentist.com)
  • Hereditary Gingival Fibromatosis (HGF) occurs when your gums overgrow your teeth. (familytreedentist.com)
  • In addition, the tendency of gum tissue to overgrow can be inherited (i.e., hereditary gingival fibromatosis - HGF) or there could be a systemic cause for the condition. (lamasdental.com)
  • Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513 (p.R250W) or Kif3c (p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. (nature.com)
  • Most HGF cases are nonsyndromic, with gingival hyperplasia as the single symptom. (nature.com)
  • Gingival Hyperplasia. (bvsalud.org)
  • Among them, we can mention Lichenoid Reactions and Gingival Hyperplasia. (cidentist.com)
  • Gingival hyperplasia induced by any of the drugs mentioned above is similar and occurs in 50% of patients treated with phenytoin, 30% with cyclosporine, and 20% with nifedipine, appearing more frequently in children and young people from the third month of treatment when a sufficient concentration of the drug has been reached in the gingival tissues. (cidentist.com)
  • One issue that can be addressed using these advanced procedures includes gingival hyperplasia (i.e., overgrown gum tissue). (lamasdental.com)
  • Certain diseases, hormonal imbalances and even pregnancy can trigger gingival hyperplasia. (lamasdental.com)
  • After treating the physiological cause of the overgrown gum tissue, gingival hyperplasia usually improves. (lamasdental.com)
  • Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. (shengsci.com)
  • For the most part, a gummy smile is caused by an overgrowth of the gingival tissue around the necks of the teeth, a short lip and small teeth. (lamasdental.com)
  • Gingival overgrowth. (lamasdental.com)
  • The affected individuals have some characteristic cherubic facies as a result of fibrous dysplasia of the mandible associated with gingival fibromatosis and overgrowth that leads to inability to close the mouth. (mhmedical.com)
  • Because of the gingival and mandibular overgrowth and dysplasia, tracheal intubation may be difficult. (mhmedical.com)
  • Known as gingival fibromatosis, this hereditary condition involves an overproduction of collagen that causes an overgrowth of gum tissue. (britedental.com.au)
  • Drug Induced Gingival Overgrowth. (edu.in)
  • Inflammation Hormonal Imbalance Neoplasia More commonly associated with an autosomal dominant gene inheritance Multi-system syndromes: Zimmerman-Laband syndrome, Jones syndrome, Ramon syndrome, Rutherford syndrome, juvenile hyaline fibromatosis, systemic infantile hyalinosis, and mannosidosis Some unknown causes Genetic linkage studies are among the most popular methods of study to look at the mechanism of this HGF. (wikipedia.org)
  • Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal recessive conditions characterized by multiple subcutaneous skin nodules, gingival hypertrophy, joint contractures, and hyaline deposition. (omeka.net)
  • Desquamative Gingivitis is one of the main gingival abnormalities not related to plaque. (cidentist.com)
  • At the gingival level, there are receptors for estrogens and progesterone, which allows these hormones to exert different effects on the gingival tissue among which are vascular, cellular, microbiological, and immunological alterations that lead to an increase in the degree of gingivitis. (cidentist.com)
  • Necrotizing ulcerative gingivitis (GUN), which is more prevalent among homosexual men, is characterized by reddened gingiva with diffuse inflammation, and there is also the involvement of the interdental papilla (necrosis) and the gingival margin, even leaving areas of bone exposed due to the loss of tissues soft. (cidentist.com)
  • If treatment for overgrown gingival tissue is not sought, the likelihood of developing gum disease (i.e., gingivitis) increases. (lamasdental.com)
  • Exposure to heavy metals (eg, lead, bismuth) may cause gingivitis and a dark line at the gingival margin. (msdmanuals.com)
  • This plaque and tartar irritate the gingival tissue, leading to inflamed, red, tender gums that easily bleed. (lamasdental.com)
  • have a cobblestone area of granulomatous gingival hypertrophy when intestinal flare-ups occur. (msdmanuals.com)
  • Depending on the severity of each case, GF may result in significant functional and aesthetic disorders, mainly related to the difficulty of cleaning, speech and swallowing due to formation of large gingival tissue masses. (bvsalud.org)
  • Typically, when we think of a movie-star's smile we visualize a set of straight, bright-white teeth with a minimal amount of gingival tissue (i.e., gum tissue) showing and contours that appear balanced with his or her upper lip. (lamasdental.com)
  • What Causes the Gingival Tissue to Overgrow? (lamasdental.com)
  • A gummy-looking smile can be the direct result of swollen gingival tissue. (lamasdental.com)
  • This is a rare genetic condition that causes a slow, progressive enlargement of the gingival tissue. (lamasdental.com)
  • The bacteria, plaque and tartar may build up beneath the overgrown gingival tissue, as the body's immune system attacks the bacteria, it also attacks this excess tissue. (lamasdental.com)
  • The broad abundance of gingival tissue is normally treated with a gingivectomy, as it creates great stylish outcomes. (imedpub.com)
  • ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)
  • In conclusion, our results reveal a role for the KCNQ1 potassium channel in the regulation of human growth, and show that growth hormone deficiency associated with maternally inherited gingival fibromatosis is an allelic disorder with cardiac arrhythmia syndromes caused by KCNQ1 mutations. (tau.ac.il)
  • There also may or may not be any signs of medical and/or family history of mental retardation, hypertrichosis, nor clinical symptoms that can be associated with gingival enlargement. (wikipedia.org)
  • Also, if this condition develops during pregnancy, once the baby is born, gingival enlargement correction via dental intervention is usually not necessary, as the condition resolves on its own. (lamasdental.com)
  • The Gingival Fibromatosis (GF) is described as a rare oral condition, clinically manifested by a slow, progressive, diffuse, and benign growth of gingival tissues. (bvsalud.org)
  • METHODS:Gingival tissues were collected from 9 HGF patients and 15 normal controls. (shengsci.com)
  • RESULTS:KCNQ1 was upregulated in gingival tissues derived from HGF patients and HGF gingival fibroblasts presented increased outward K+ currents than NHGFs. (shengsci.com)
  • Aggressive periodontitis, Fibrocellular proliferation, Gingival fibromatosis, Puberty onset, Vertical bone loss around first molars INTRODUTION Journal of Clinical and Diagnostic Research. (dokumen.tips)
  • Jones syndrome is an extremely rare disorder characterized by gingival fibromatosis and sensorineural hearing loss . (mdwiki.org)
  • Gingival Fibromatosis Hypertrichosis Cherubism Mental Retardation Epilepsy Syndrome. (mhmedical.com)
  • Normal human gingival fibroblasts (NHGFs) were transfected with KCNQ1 adenovirus or treated with KCNQ1 selective agonist ML277 and antagonist chromanol 293B. (shengsci.com)
  • The occurrence of childhood GHD in association with gingival fibromatosis led to the identification of two autosomal dominant KCNQ1 missense variants (Arg116Leu and Pro369Leu). (endocrine-abstracts.org)
  • ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
  • Gingival fibroblasts were isolated, and outward K+ currents were detected by whole-cell patch-clamp analysis, transmembrane potential was determined by flow cytometry. (shengsci.com)
  • Necropsy showed several flattened and smooth tumorous lesions on the inner aspects of the upper and lower lips, as well as multiple small, partly ulcerated nodules at the gingival margin of the upper and lower jaw ( Figure 1 , panel B). (cdc.gov)
  • Rare disorder (about 50 patients reported) characterized by gingival fibromatosis, dysplastic or absent nails, hypoplasia of the distal phalanges, scoliosis, hepatosplenomegaly, hirsutism, and abnormalities of the cartilage of the nose and/or ears. (mhmedical.com)
  • This paper proposes a review of the clinical features, diagnosis and treatment of gingival fibromatosis and reports a severe case of this condition that was surgically treated. (bvsalud.org)
  • Henceforth, there have been conversations at times by which all teeth between the main molars are remembered for the strategy, particularly in careful crown protracting, to accomplish a stylishly satisfying gingival design mixing in agreeably the gingival forms of the maxillary foremost and back teeth. (imedpub.com)
  • In a review correlation between various treatment way to deal with periodontitis the board in light of the underlying and last gingival wellbeing, customary gingivectomy was demonstrated to find actual success in lessening pocket profundities and irritation contrasted with non-careful medicines in pockets estimated 3mm or more. (imedpub.com)
  • The Department of Periodontics encompasses diagnosis and management of gingival and periodontal diseases using surgical and non surgical modalities. (edu.in)
  • Specific linkage studies have localized the mutation for isolated, nonsyndromic autosomal dominant forms of gingival fibromatosis to chromosomes 2 and 5, more specifically 2p21-p22 and 5q13-q22. (wikipedia.org)
  • There was no significant pain and the probing revealed little sub- gingival plaque and calculus.Routine hematological investigations revealed normal readings. (dokumen.tips)
  • Irritation due to plaque deepens the normal crevice (sulcus) between the tooth and gingiva, creating gingival pockets. (msdmanuals.com)
  • Dental/gingival morphologic attributes and peri-oral factors impact patient's grin outline. (imedpub.com)
  • Since the disease is prone to recurrence after surgery, HGF patients must undergo repeated surgical procedures of gingival resection, which brings a heavy psychological and economic burden to HGF patients and their families. (nature.com)
  • B) Multinodular fissured masses at the gingival margin. (cdc.gov)
  • One more reason for gingival broadening would be an innate condition known as gingival fibromatosis. (imedpub.com)
  • Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. (tau.ac.il)