Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)
'Mouth diseases' is a broad term referring to various conditions that cause inflammation, infection, or structural changes in any part of the mouth, including the lips, gums, tongue, palate, cheeks, and teeth, which can lead to symptoms such as pain, discomfort, difficulty in chewing or speaking, and altered aesthetics.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Oral focal epithelial hyperplasia in a howler monkey (Alouatta fusca). (1/11)

Oral focal epithelial hyperplasia is a rare and seldom reported disease in animals and humans induced by a papillomavirus. The present report is the first description of this disease in a Neotropical primate, a howler monkey (Alouatta fusca). The diagnosis was based on gross and microscopic findings. The generic papillomavirus antigen was identified by immunohistochemistry and was found not to be related to any human papillomavirus DNA tested by in situ hybridization. This virus is probably a specific papillomavirus of the howler monkey (HMPV).  (+info)

Focal epithelial hyperplasia. A rare disease in our area. (2/11)

Focal epithelial hyperplasia is a benign, asymptomatic disease, occurring with very low frequency within our population. It appears as papules, principally on the lower lip, although it can also be found on the retro-commissural mucosa and tongue, and less frequently on the upper lip, gingiva and palate. We present the clinical case of a 9-year-old Saharan girl with lesions that clinically and histologically corresponded to a focal epithelial hyperplasia.  (+info)

Multifocal epithelial hyperplasia. Report of nine cases. (3/11)

Multifocal epithelial hyperplasia (MEH) is also known as focal epithelial hyperplasia, Heck's disease or multifocal papillomavirus-induced epithelial hyperplasia. It is characterised by the presence of multiple lesions in the oral mucosa of children and it has been associated with the presence of the human papillomavirus. The aim of this study was to determine the clinico-pathological features of the cases diagnosed as MEH in the Service of Dermatology of the Hospital Manuel Gea Gonzalez (SDHMGG). The files of the SDHMGG were reviewed and all cases diagnosed as MEH were retrieved. Nine MEH cases were found. Most of the patients were 20 year-old or younger (67%) and females were more commonly affected (78%). All patients presented multiple lesions and always, close relatives with similar lesions were found. Lesions were located most commonly in the buccal mucosa, lower lip and commissures. MEH is a soft tissue intraoral condition that needs treatment solely of the traumatised lesions or those with cosmetic problems. Remaining lesions will disappear with the age of the patients. It is suggested that this entity should be named multifocal epithelial hyperplasia since this name describes better the clinico-pathological and microscopic features of the disease.  (+info)

Extensive focal epithelial hyperplasia: case report. (4/11)

Focal epithelial hyperplasia (FEH) is a rare benign lesion caused by human papillomavirus subtype 13 or 32. The condition occurs in numerous populations and ethnic groups. A higher incidence in close communities and among family members indicates infectious pathogenesis. A 21-year-old woman with FEH is described, in whom the lesions had persisted for 10 years. A literature review is also presented, with emphasis on manifestations in the oral mucosa and histopathological features.  (+info)

Extensive papillomatosis of the palate exhibiting epithelial dysplasia and HPV 16 gene expression in a renal transplant recipient. (5/11)

We report a unique case of extensive papillomatosis of the palate in a renal transplant recipient. The condition resembled inflammatory papillary hyperplasia; it exhibited severe epithelial dysplasia and concurred with generalized gingival hyperplasia. We document and discuss the probable multifactorial etiology of the lesions, including evidence for human papillomavirus (HPV) type 16 expression, as detected by in situ reverse transcription polymerase chain reaction. This report illustrates the need for careful clinical investigation and follow-up of immunosuppressed individuals presenting with apparently benign, common oral lesions.  (+info)

Oral focal epithelial hyperplasia: report of five cases. (6/11)

Focal epithelial hyperplasia or Heck's disease is a rare contagious disease caused by human papillomavirus types 13 or 32, initially described among Native American populations. This condition is characterized by the occurrence of multiple small papules or nodules in oral cavity, especially on labial and buccal mucosa and tongue. This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing.  (+info)

TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. (7/11)

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HER-2/neu expression in lesions of uterine cervix: is it reliable and consistent? (8/11)

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Focal epithelial hyperplasia, also known as Heck's disease, is a rare, benign oral condition characterized by the proliferation of squamous epithelial cells. It typically presents as multiple, small, white or red, smooth or papillary lesions on the mucous membranes of the mouth, such as the tongue, lips, and buccal mucosa. The lesions are usually painless and asymptomatic, although they may cause some discomfort during speaking, chewing, or swallowing.

The condition is often associated with human papillomavirus (HPV) infection, particularly types 13 and 32. It primarily affects children and young adults, and is more commonly found in Native American populations. The lesions typically regress spontaneously within a few years, although treatment options such as surgical excision or laser ablation may be considered for cosmetic reasons or if the lesions are causing discomfort.

Mouth diseases refer to a variety of conditions that affect the oral cavity, including the lips, gums, teeth, tongue, palate, and lining of the mouth. These diseases can be caused by bacteria, viruses, fungi, or other organisms. They can also result from injuries, chronic illnesses, or genetic factors.

Some common examples of mouth diseases include dental caries (cavities), periodontal disease (gum disease), oral herpes, candidiasis (thrush), lichen planus, and oral cancer. Symptoms may include pain, swelling, redness, bleeding, bad breath, difficulty swallowing or speaking, and changes in the appearance of the mouth or teeth. Treatment depends on the specific diagnosis and may involve medications, dental procedures, or lifestyle changes.

The mouth mucosa refers to the mucous membrane that lines the inside of the mouth, also known as the oral mucosa. It covers the tongue, gums, inner cheeks, palate, and floor of the mouth. This moist tissue is made up of epithelial cells, connective tissue, blood vessels, and nerve endings. Its functions include protecting the underlying tissues from physical trauma, chemical irritation, and microbial infections; aiding in food digestion by producing enzymes; and providing sensory information about taste, temperature, and texture.

Hyperplasia is a medical term that refers to an abnormal increase in the number of cells in an organ or tissue, leading to an enlargement of the affected area. It's a response to various stimuli such as hormones, chronic irritation, or inflammation. Hyperplasia can be physiological, like the growth of breast tissue during pregnancy, or pathological, like in the case of benign or malignant tumors. The process is generally reversible if the stimulus is removed. It's important to note that hyperplasia itself is not cancerous, but some forms of hyperplasia can increase the risk of developing cancer over time.

... (FEH) or Hecks disease is a rare, benign, oral condition that is associated with infection by ... focal epithelial hyperplasia; human papillomavirus 13; human papillomavirus 32; multifocal epithelial hyperplasia. ... Focal Epithelial Hyperplasia Viruses. 2021 Aug 2;13(8):1529. doi: 10.3390/v13081529. ... Focal epithelial hyperplasia (FEH) or Hecks disease is a rare, benign, oral condition that is associated with infection by ...
... By Dr. Stephen Cohen. Read About Diseases, Conditions & Injuries. Free To Browse, Download & Quote ... Fixed drug eruption → Focal segmental glomerulosclerosis Leave a Reply Cancel reply. Your email address will not be published. ...
Extensive focal epithelial hyperplasia. Arch Iran Med 2010; 13:48-52. 7. Del Boz J, Funez R. Hiperplasia epitelial focal em ... Focal epithelial hyperplasia. Lyon: IARC Press; 2005. p. 184.. 3. Kumaraswamy KL, Vidhya M. Human papilloma virus and oral ... 9. Pilgard G. Focal epithelial hyperplasia. Report of nine cases from Sweden and review of the literature. Oral Surg Oral Med ... Focal Epithelial Hyperplasia is a relatively rare lesion1-7 first described in 196511. Retrospective studies show that FEH has ...
Focal Epithelial hyperplasia -Mitosoid cells. February 24, 2012. by Dr. Varun Pandula Leave a Comment ...
Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found ... Hecks disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by ... "Focal epithelial hyperplasia (Hecks disease)". Annali di Stomatologia. 4 (Suppl 2): 43. ISSN 1824-0852. PMC 3860189. PMID ...
Focal epithelial hyperplasia, or Heck disease (HPV-13, HPV-32), may appear as an epidemic in young adults in small communities ... Extensive focal epithelial hyperplasia: case report. J Can Dent Assoc. 2005 Nov. 71(10):769-71. [QxMD MEDLINE Link]. ... Focal epithelial hyperplasia (Heck disease) exhibits acanthosis of the spinous layer and thickened, fused rete pegs. The ... Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J. Focal epithelial hyperplasia (Heck disease) related to highly ...
Focal epithelial hyperplasia, or Heck disease (HPV-13, HPV-32), may appear as an epidemic in young adults in small communities ... Extensive focal epithelial hyperplasia: case report. J Can Dent Assoc. 2005 Nov. 71(10):769-71. [QxMD MEDLINE Link]. ... Focal epithelial hyperplasia (Heck disease) exhibits acanthosis of the spinous layer and thickened, fused rete pegs. The ... Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J. Focal epithelial hyperplasia (Heck disease) related to highly ...
Dermoscopy of focal epithelial hyperplasia. Ali Al Ameer, Feroze Kaliyadan, Yusef M Almarzooq, Maryam Imran, Hassan F Alkhars. ... extremities and was diagnosed as a case of ML with the help of clinico-radiological studies and presented here because of focal ...
Focal epithelial hyperplasia. *Idiopathic thrombocytopenia purpura. Diagnosis. *Hereditary hemorrhagic telangiectasia. ...
Inflammatory cell infiltrates, focal epithelial necrosis and minimal diffuse epithelial hyperplasia could still be observed. ... Inflammatory cell infiltrates, focal epithelial necrosis and minimal diffuse epithelial hyperplasia could still be observed. ... focal epithelial hyperplasia (level II) in males and females were observed in the larynx. In the trachea, focal squamous ... A minimal focal epithelial hyperplasia occurred in all males and in 4 females. A mostly minimal inflammation was observed in 2 ...
Maschke J, Brauns TC, Goos M. Imiquimod for the topical treatment of focal epithelial hyperplasia (Heck disease) in a child. J ... Yasar S, Mansur AT, Serdar ZA, Goktay F, Aslan C. Treatment of focal epithelial hyperplasia with topical imiquimod: Report of ... Ponte P, Serrão V, Fiadeiro T. Focal epithelial hyperplasia (Hecks Disease) in two siblings: Response to treatment with ... Focal epithelial hyperplasia-an update. J Oral Pathol Med 2013;42:435-42. ...
At 10 ppm (LOAEC) focal squamous metaplasia, hyperplasia, and keratinization as well as epithelial disarrangement were seen in ... The changes included papillary epithelial hyperplasia in the forestomach and focal atrophic gastritis occasionally accompanied ... Treatment related lesions were detected only in the forestomach (focal papillary epithelial hyperplasia, ulceration and ... Treatment related lesions were detected in the forestomach (focal papillary epithelial hyperplasia, ulceration and ...
This showed "fibrocystic changes and moderate epithelial hyperplasia. There is no microcalcification." These benign changes ... This showed, "focal areas of hyperthermia at two oclock in the left breast that warrants clinical correlation and close ...
Histologic examination of both nodules (Appendix) revealed severe papillary epithelial hyperplasia, acanthosis, ballooning ... In the liver, we detected a focally necrotizing hepatitis with ballooning degeneration of nuclei and a focal granulomatous ... A) Histopathology of nodules shows severe papillary epithelial... * Figure 2. Phylogenetic tree of novel poxvirus detected from ... the heart had focal severe mononuclear myocarditis; and the duodenum had moderate diffuse lymphoplasmacellular enteritis. We ...
... with epithelial hyperplasia and apoptosis overlaying areas of scarring with fibroblast foci. In a focal manner, the alveolar ... Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008 ... Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. J ... Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia. Am J Respir Crit Care Med ...
Forestomach: epithelial hyperplasia (8/50, 21/50, 33/49, 44/50) Glandular stomach: focal epithelial hyperplasia (0/50, 10/50, ... Forestomach: epithelial hyperplasia (8/50, 27/50, 38/50, 43/50) Glandular stomach: focal epithelial hyperplasia (1/50, 19/50, ... In the glandular stomach, incidences of focal epithelial hyperplasia, epithelial cyst (except 10 mg/kg females), and subtle ... bile duct hyperplasia (12/50, 26/50, 29/49, 38/49); oval cell hyperplasia (0/50, 7/50, 24/49, 36/49); nodular hyperplasia (1/50 ...
A subtype of oral warts is Heck disease, also known as focal epithelial hyperplasia, which consists of multiple (or, rarely, ... The virus infects epithelial cells and can exist as a long-term latent infection that can reactivate or persist actively, even ...
Focal epithelial hyperplasia, or Heck disease (HPV-13, HPV-32), may appear as an epidemic in young adults in small communities ... Extensive focal epithelial hyperplasia: case report. J Can Dent Assoc. 2005 Nov. 71(10):769-71. [QxMD MEDLINE Link]. ... Focal epithelial hyperplasia (Heck disease) exhibits acanthosis of the spinous layer and thickened, fused rete pegs. The ... Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J. Focal epithelial hyperplasia (Heck disease) related to highly ...
focal epithelial hyperplasia DOID:5362 * cutaneous ganglioneuroma DOID:2425 * inflammatory leiomyosarcoma DOID:5251 ...
benign epithelial* papillomas* squamous papilloma* condyloma acuminatum* focal epithelial hyperplasia* granular cell tumor* ... epithelial precursor lesions* squamous cell hyperplasia* dysplasia* mild* moderate* severe* carcinoma in situ* ... malignant epithelial* SCC* verrucous carcinoma* basaloid SCC* papillary SCC* spindle cell carcinoma* acantholytic SCC* ... focal oral mucinosis* congenital granular cell epulis* fibroma* lobular capillary hemangioma* peripheral ossifying fibroma* ...
Virus diseases -- 5.3.1. Warts -- 5.3.2. Focal epithelial hyperplasia -- 5.3.3. Condyloma acuminatum -- 5.3.4. Moluscum ...
Focal epithelial hyperplasia of neuroendocrine cells. INHAND:. Hyperplasia, neuroendocrine cell. Case #3. Species/Strain: CD1 ... Multifocal basal cell hyperplasia of the prostate and multifocal basal cell hyperplasia with squamous metaplasia of the ... Atrophy, cortex; Hyperplasia, lymphoid, medulla; Loss of corticomedullary distinction. Enhanced histopathology: Lymphocytes ...
... septae due to the infiltration of primarily mononuclear inflammatory cells and hypertrophy/hyperplasia of alveolar epithelial ... Inflammatory changes were usually focal to multifocal. Only when the severity was grade 3 to 4 did the inflammatory foci tend ... cortical proximal convoluted tubules which were lined by epithelial cells that were slightly vacuolated with nuclear pyknosis ... increased perivascular cuffing by mononuclear inflammatory cells and a variable hyperplasia of the bronchiolar associated ...
Marvan, E. and Firth, N. (1998). Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the ... Firth, Norman (2011). Cysts and other epithelial lesions involving or contiguous with teeth: diagnostic essentials. ... a focal defect or a beginning of a widespread disease?. Pathology, 41, 65. doi: 10.1097/01268031-200941001-00147 ... A Double-Clear Variant of Epithelial-Myoepithelial Carcinoma of the Parotid Gland. Head and Neck Pathology, 6 (4), 471-475. doi ...
Hecks disease (focal epithelial hyperplasia) - HPV types 13 and 32.. Causes. When the human papillomavirus (HPV) enters a cut ...
Focal epithelial hyperplasia caused by human papillomavirus 13. Saunders, Natasha R; Scolnik, Dennis; Rebbapragada, Anuradha; ... Focal epithelial hyperplasia is a benign, papulo-nodular disease of the oral cavity. It is rare, affecting primarily Native ... This report describes the diagnosis of 2 cases of focal epithelial hyperplasia in children from southern Guyana. The diagnosis ... Hiperplasia Epitelial Focal/diagnóstico , Hiperplasia Epitelial Focal/patologia , Guiana , Humanos , Masculino , Infecções por ...
Focal epithelial hyperplasia - an update. J Oral Pathol Med. 2013 Jul;42(6):435-42. doi: 10.1111/jop.12009. Epub 2012 Oct 14. ... Extensive focal epithelial hyperplasia: case report. J Can Dent Assoc. 2005 Nov;71(10):769-71. ...

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