Focal Epithelial Hyperplasia
Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)
Mouth Diseases
'Mouth diseases' is a broad term referring to various conditions that cause inflammation, infection, or structural changes in any part of the mouth, including the lips, gums, tongue, palate, cheeks, and teeth, which can lead to symptoms such as pain, discomfort, difficulty in chewing or speaking, and altered aesthetics.
Mouth Mucosa
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Oral focal epithelial hyperplasia in a howler monkey (Alouatta fusca). (1/11)
Oral focal epithelial hyperplasia is a rare and seldom reported disease in animals and humans induced by a papillomavirus. The present report is the first description of this disease in a Neotropical primate, a howler monkey (Alouatta fusca). The diagnosis was based on gross and microscopic findings. The generic papillomavirus antigen was identified by immunohistochemistry and was found not to be related to any human papillomavirus DNA tested by in situ hybridization. This virus is probably a specific papillomavirus of the howler monkey (HMPV). (+info)Focal epithelial hyperplasia. A rare disease in our area. (2/11)
Focal epithelial hyperplasia is a benign, asymptomatic disease, occurring with very low frequency within our population. It appears as papules, principally on the lower lip, although it can also be found on the retro-commissural mucosa and tongue, and less frequently on the upper lip, gingiva and palate. We present the clinical case of a 9-year-old Saharan girl with lesions that clinically and histologically corresponded to a focal epithelial hyperplasia. (+info)Multifocal epithelial hyperplasia. Report of nine cases. (3/11)
Multifocal epithelial hyperplasia (MEH) is also known as focal epithelial hyperplasia, Heck's disease or multifocal papillomavirus-induced epithelial hyperplasia. It is characterised by the presence of multiple lesions in the oral mucosa of children and it has been associated with the presence of the human papillomavirus. The aim of this study was to determine the clinico-pathological features of the cases diagnosed as MEH in the Service of Dermatology of the Hospital Manuel Gea Gonzalez (SDHMGG). The files of the SDHMGG were reviewed and all cases diagnosed as MEH were retrieved. Nine MEH cases were found. Most of the patients were 20 year-old or younger (67%) and females were more commonly affected (78%). All patients presented multiple lesions and always, close relatives with similar lesions were found. Lesions were located most commonly in the buccal mucosa, lower lip and commissures. MEH is a soft tissue intraoral condition that needs treatment solely of the traumatised lesions or those with cosmetic problems. Remaining lesions will disappear with the age of the patients. It is suggested that this entity should be named multifocal epithelial hyperplasia since this name describes better the clinico-pathological and microscopic features of the disease. (+info)Extensive focal epithelial hyperplasia: case report. (4/11)
Focal epithelial hyperplasia (FEH) is a rare benign lesion caused by human papillomavirus subtype 13 or 32. The condition occurs in numerous populations and ethnic groups. A higher incidence in close communities and among family members indicates infectious pathogenesis. A 21-year-old woman with FEH is described, in whom the lesions had persisted for 10 years. A literature review is also presented, with emphasis on manifestations in the oral mucosa and histopathological features. (+info)Extensive papillomatosis of the palate exhibiting epithelial dysplasia and HPV 16 gene expression in a renal transplant recipient. (5/11)
We report a unique case of extensive papillomatosis of the palate in a renal transplant recipient. The condition resembled inflammatory papillary hyperplasia; it exhibited severe epithelial dysplasia and concurred with generalized gingival hyperplasia. We document and discuss the probable multifactorial etiology of the lesions, including evidence for human papillomavirus (HPV) type 16 expression, as detected by in situ reverse transcription polymerase chain reaction. This report illustrates the need for careful clinical investigation and follow-up of immunosuppressed individuals presenting with apparently benign, common oral lesions. (+info)Oral focal epithelial hyperplasia: report of five cases. (6/11)
Focal epithelial hyperplasia or Heck's disease is a rare contagious disease caused by human papillomavirus types 13 or 32, initially described among Native American populations. This condition is characterized by the occurrence of multiple small papules or nodules in oral cavity, especially on labial and buccal mucosa and tongue. This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing. (+info)TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. (7/11)
(+info)HER-2/neu expression in lesions of uterine cervix: is it reliable and consistent? (8/11)
(+info)Focal Epithelial Hyplasia (FEH), also known as Heck's disease, is a rare, benign oral condition characterized by the proliferation of squamous epithelium, often presenting as white or red painless papules or plaques, typically found in immunocompromised individuals, including those with HIV infection.
Focal epithelial hyperplasia, also known as Heck's disease, is a rare, benign oral condition characterized by the proliferation of squamous epithelial cells. It typically presents as multiple, small, white or red, smooth or papillary lesions on the mucous membranes of the mouth, such as the tongue, lips, and buccal mucosa. The lesions are usually painless and asymptomatic, although they may cause some discomfort during speaking, chewing, or swallowing.
The condition is often associated with human papillomavirus (HPV) infection, particularly types 13 and 32. It primarily affects children and young adults, and is more commonly found in Native American populations. The lesions typically regress spontaneously within a few years, although treatment options such as surgical excision or laser ablation may be considered for cosmetic reasons or if the lesions are causing discomfort.
'Mouth diseases' is a broad term referring to various conditions that cause inflammation, infection, or structural changes in any part of the mouth, including the lips, gums, tongue, palate, cheeks, and teeth, which can lead to symptoms such as pain, discomfort, difficulty in chewing or speaking, and altered aesthetics.
Mouth diseases refer to a variety of conditions that affect the oral cavity, including the lips, gums, teeth, tongue, palate, and lining of the mouth. These diseases can be caused by bacteria, viruses, fungi, or other organisms. They can also result from injuries, chronic illnesses, or genetic factors.
Some common examples of mouth diseases include dental caries (cavities), periodontal disease (gum disease), oral herpes, candidiasis (thrush), lichen planus, and oral cancer. Symptoms may include pain, swelling, redness, bleeding, bad breath, difficulty swallowing or speaking, and changes in the appearance of the mouth or teeth. Treatment depends on the specific diagnosis and may involve medications, dental procedures, or lifestyle changes.
'Mouth mucosa' refers to the mucous membrane that lines the interior of the mouth, including the cheeks, tongue, palate, and floor of the mouth, which is responsible for providing a protective barrier, facilitating sensation, and aiding in digestion.
The mouth mucosa refers to the mucous membrane that lines the inside of the mouth, also known as the oral mucosa. It covers the tongue, gums, inner cheeks, palate, and floor of the mouth. This moist tissue is made up of epithelial cells, connective tissue, blood vessels, and nerve endings. Its functions include protecting the underlying tissues from physical trauma, chemical irritation, and microbial infections; aiding in food digestion by producing enzymes; and providing sensory information about taste, temperature, and texture.
Hyperplasia is an abnormal multiplication and growth of cells leading to an increase in the size of a tissue or organ, which can be physiological or pathological, responding to various stimuli such as hormones, mitogens, or chronic irritation.
Hyperplasia is a medical term that refers to an abnormal increase in the number of cells in an organ or tissue, leading to an enlargement of the affected area. It's a response to various stimuli such as hormones, chronic irritation, or inflammation. Hyperplasia can be physiological, like the growth of breast tissue during pregnancy, or pathological, like in the case of benign or malignant tumors. The process is generally reversible if the stimulus is removed. It's important to note that hyperplasia itself is not cancerous, but some forms of hyperplasia can increase the risk of developing cancer over time.
Heck's disease
Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found ... Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by ... "Focal epithelial hyperplasia (Heck's disease)". Annali di Stomatologia. 4 (Suppl 2): 43. ISSN 1824-0852. PMC 3860189. PMID ...
Epidermis
Focal epithelial hyperplasia (Heck's disease) is an asymptomatic, benign neoplastic condition characterized by multiple white ... Tenore G, Palaia G, Del Vecchio A, Galanakis A, Romeo U (2013-10-24). "Focal epithelial hyperplasia (Heck's disease)". Annali ... Epidermal hyperplasia (thickening resulting from cell proliferation) has various forms: Acanthosis is diffuse epidermal ... In contract, hyperkeratosis is a thickening of the stratum corneum, and is not necessarily due to hyperplasia. Epidermis and ...
Papilloma
Intraoral verruca vulgaris, Condyloma acuminatum, and Focal epithelial hyperplasia. Note: differentiation is done accurately by ... A papilloma (plural papillomas or papillomata) (papillo- + -oma) is a benign epithelial tumor growing exophytically (outwardly ...
Wart
Butcher's warts - HPV type 7. Heck's disease (focal epithelial hyperplasia) - HPV types 13 and 32. Common warts have a ...
Sialadenitis
In addition, it may also present ductal epithelial proliferation which could range from hyperplasia, atypia to DCIS-like. Its ... Chronic sclerosing sialadenitis has various degrees of inflammation which can include focal lymphocytic sialadenitis to ... A distinguishing feature is the presence of epithelial-myoepithelial islands infiltrated by lymphocytes. Germinal centers may ... stroma may show focal adipose tissue with myxoid change and variable radial scar. At present, there are immunohistochemical ...
List of skin conditions
... focal epithelial hyperplasia) Hemorrhagic fever with renal syndrome Hepatitis B Hepatitis C Herpangina Herpes gladiatorum ( ... Focal palmoplantar and gingival keratosis Focal palmoplantar keratoderma with oral mucosal hyperkeratosis (focal epidermolytic ... Spiegler-Fendt lymphoid hyperplasia, Spiegler-Fendt sarcoid) Cutaneous lymphoid hyperplasia with bandlike and perivascular ... ISBN 978-0-7817-4088-3. McLean WH; Epithelial Genetics, Group (2003). "Genetic disorders of palm skin and nail". J Anat. 202 (1 ...
Hyperplasia
Focal epithelial hyperplasia (also known as Heck's disease) - This is a wart-like growth in the mucous tissues of the mouth or ... Hyperplasia of the breast - "Hyperplastic" lesions of the breast include usual ductal hyperplasia, a focal expansion of the ... Hyperplasia of certain tissues may cause disease. Pathologic hyperplasia in these tissues may occur due to infection, ... Similarly to physiological hyperplasia, cells that undergo pathologic hyperplasia are controlled by growth hormones, and cease ...
HIV-associated nephropathy
... of collapsing glomerulopathy is collapse of glomerular tuft and proliferation and hyperplasia of glomerular visceral epithelial ... The most common, or "classical", type of HIV-associated nephropathy is a collapsing focal segmental glomerulosclerosis (FSGS), ... Typical findings are that of collapsing capillary loops, areas of scarring called focal segmental glomerulosclerosis (FSGS), ...
Anton Elschnig
"Elschnig's pearls": Pearl-like clusters formed by growth of epithelial cells on the lens capsule in secondary cataract ... It occurs in cases of advanced hypertensive retinopathy, represent focal choroidal infarcts. Ophthalmology Hall of Fame ( ... "Elschnig's conjunctivitis": Conjunctivitis associated with hyperplasia of the tarsal gland. " ...
Adenomyoma
The excessive proliferation of epithelial cells causes the mucosa to invaginate into the muscular layer lining the gallbladder ... Gallbladder adenomyomatosis is a benign disease of the gallbladder characterized by hyperplasia of the mucosal epithelium and ... Women with uterine adenomyomas (focal adenomyosis) more commonly have co-existing endometriosis and a higher likelihood of ... Uterine adenomyoma is the focal form of uterine adenomyosis. Adenomyosis most commonly presents with numerous small collections ...
Congenital tufting enteropathy
Most notably focal epithelial tufts were found on the surface epithelium. These tufts were composed of closely packed ... A number of jejunal biopsies had been taken during life and these showed partial villous atrophy with by crypt hyperplasia and ... Goulet, O; Salomon, J; Ruemmele, F; Patey-Mariaud de Serres, N; Brousse, N (2007). "Intestinal epithelial dysplasia (tufting ... The most important feature involves the epithelium where the surface enterocytes are disorganized with focal crowding creating ...
Minimally invasive adenocarcinoma of the lung
Atypical adenomatous hyperplasia of the lung Adenocarcinoma in situ of the lung Adenocarcinoma of the lung Lambe, Gerard; ... with a zone of focal invasion of the stroma with a size inferior to 5 mm. For MIA-as with adenocarcinoma in situ-, the ... solitary tumour with predominant alveolar epithelial appearance (lepidic growth), as in situ adenocarcinoma of the lung, ...
Index of oral health and dental articles
Hertwig's epithelial root sheath • Heterodont • Hexetidine • History of dental treatments • Horace H. Hayden • Horace Wells • ... Focal infection • Foliate papillae • Forensic dentistry • Frank Abbott (dentist) • Frank Crowther • Frederick B. Moorehead • ... Inflammatory papillary hyperplasia • Ingestion • Inlays and onlays • Inner enamel epithelium • Interdental brush • Interdental ... Calcifying epithelial odontogenic tumor • Calcifying odontogenic cyst • Calcium hydroxide • Calculus • California Dental ...
Dentigerous cyst
Focal areas of mucus cells or rarely, ciliated columnar cells may be found in the epithelial lining of dentigerous cysts. In ... The cyst is lined mostly or entirely by non-keratinizing squamous epithelium which display varying amounts of hyperplasia with ... The epithelial lining is composed of two to four layers of flattened non-keratinizing cells, with a flat epithelium and ... Transformation from normal epithelial cyst lining to SCC is due to chronic inflammation. It is likely that some intraosseous ...
Stomach cancer
Wall thickening of more than 1 cm that is focal, eccentric, and enhancing favours malignancy. In 2013, Chinese and Israeli ... A condition of darkened hyperplasia of the skin, frequently of the axilla and groin, known as acanthosis nigricans, is ... Gastric adenocarcinoma is a malignant epithelial tumour, originating from glandular epithelium of the gastric mucosa. Stomach ... Other cutaneous manifestations of gastric cancer include "tripe palms" (a similar darkening hyperplasia of the skin of the ...
Thyroid neoplasm
... with focal expression of thyroglobulin (c) and expression of T4 (d); in this case, TTF1 was diffusely expressed. Biphasic ... Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a lobulated tumor composed of spindle cells and ... Non-hyperfunctioning adenomas with papillary hyperplasia usually show a more predominantly papillary pattern without vacuolated ... and very focal expression of thyroglobulin i Lipid-rich follicular thyroid carcinoma (a) immunoreactive for thyroglobulin (b); ...
Cyclin D
Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A, Schmidt EV (June 1994). "Mammary hyperplasia and carcinoma in MMTV-cyclin ... Rho family GTPases, integrin linked kinase and focal adhesion kinase (FAK) activate cyclin D gene in response to integrin. ... September 2004). "Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin ...
NEO1
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal ... "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & ... "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial ... "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204-12. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216 ...
Epstein-Barr virus-associated lymphoproliferative diseases
... lymph nodes have areas of hyperplasia, focal necrosis, and small granulomas; spleen shows atrophy of white pulp with congested ... epithelial cells that line the oral mucosa of the newly infected individual. The freed virus then invades naïve B cells located ... this disorder is characterized by hyperplasia of plasma cells, florid hyperplasia of lymph node follicles, and infectious ... Kunitomi A, Hasegawa Y, Asano N, Kato S, Tokunaga T, Miyata Y, Iida H, Nagai H (May 2018). "EBV-positive Reactive Hyperplasia ...
PAK1
... "p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells". The Journal of ... "Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and ... "P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium ... a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions". Cancer ...
CYR61
As a cell adhesive substrate, CYR61 induces the activation of focal adhesion kinase, paxillin, RAC, and sustained activation of ... CYR61 activates Akt signaling in thymic epithelial cells, promoting their proliferation and thus thymic size growth. CYR61 has ... Suppression of CYR61 expression results in reduced neointimal hyperplasia after balloon angioplasty, an effect that is reversed ... "Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output". Nature ...
Neuregulin 1
Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, ... However, studies have shown NRG-1 promotes myocardial regeneration through hyperplasia, and prevents hypertrophy surrounding ... and focal adhesion kinase (FAK). The beneficial effects of neuregulin-1 make recombinant human neuregulin-1 (rhNRG-1) a ... "Extended therapeutic window and functional recovery after intraarterial administration of neuregulin-1 after focal ischemic ...
CDKN1B
Many epithelial cancers are known to overexpress EGFR which plays a role in the proteolysis of p27 and in Ras-driven ... Because inhibition of RhoA results in a decrease in both stress fibers and focal adhesion, cell motility is increased. P27 can ... multiple organ hyperplasia, retinal dysplasia, and pituitary tumors". Cell. 85 (5): 707-20. doi:10.1016/S0092-8674(00)81237-4. ... Non-epithelial cancers use different pathways to inactivate p27. Many cancer cells also upregulate Skp2 which is known to play ...
Breast cancer
... multi-focal cancer). Incidence of multi-centric and multi-focal breast cancers (MMBC) is increasing, partly due to improving ... Breast changes like atypical ductal hyperplasia and lobular carcinoma in situ, found in benign breast conditions such as ... Abnormal growth factor signaling in the interaction between stromal cells and epithelial cells can facilitate malignant cell ... GATA-3 directly controls the expression of estrogen receptor (ER) and other genes associated with epithelial differentiation, ...
Angiofibroma
Oral fibromas are also termed irritation fibromas, focal fibrous hyperplasia, and traumatic fibromas. These lesions are nodules ... "Histopathological analysis of the association between mucosal epithelial changes and the lamina propria vascular network in ...
Cataract surgery
In cases where the focal length of the IOL is optimised for distance vision, reading glasses are generally needed for near ... Research into the possibility of regeneration of infant lenses from lens epithelial cells showed interesting results in a small ... posterior capsular cells usually undergo hyperplasia and cellular migration as part of a physiological change, showing up as a ... Although most people can adjust to having monofocal IOLs with differing focal length, some cannot compensate and may experience ...
Melanoma
The brown pigment is a focal deposition of melanin. A dermatoscope Malignant Melanoma, right posterior thigh Melanoma in situ, ... "intra-epithelial" type of melanoma. Melanomas that spread usually do so to the lymph nodes in the area of the tumor before ... a medial right temple with adjacent sebaceous hyperplasia, lateral Malignant Melanoma in situ, left anterior shoulder marked ...
List of OMIM disorder codes
... focal segmental, 1; 603278; ACTN4 Glomerulosclerosis, focal segmental, 2; 603965; TRPC6 Glomerulosclerosis, focal segmental, 3 ... TP53 Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency; 202010; CYP11B1 Adrenal hyperplasia, congenital, ... epithelial basement membrane; 121820; TGFBI Corneal dystrophy, Fuchs endothelial, 1; 136800; COL8A2 Corneal dystrophy, Fuchs ... KLKB1 Focal cortical dysplasia, Taylor balloon cell type; 607341; TSC1 Focal dermal hypoplasia; 305600; PORCN Folate ...
PTPN11
An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". J. Cell Biol. 152 (2): 325-34. doi:10.1083/jcb. ... resulting in regenerative hyperplasia and spontaneous development of tumors. Decreased PTPN11/Shp2 expression was detected in a ... "Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility". Mol. Cell. Biol. 19 ... controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". ...
Complications of hypertension
Tracy RE, White S (February 2002). "A method for quantifying adrenocortical nodular hyperplasia at autopsy: some use of the ... Swift PA, Macgregor GA (January 2004). "Genetic variation in the epithelial sodium channel: a risk factor for hypertension in ... This stage corresponds to more severe generalized and focal areas of arteriolar narrowing, changes in the arteriolar and ... Persistently elevated blood pressure leads to intimal thickening, hyperplasia of the media wall, and hyaline degeneration in ...