Fritillaria
Okibacterium fritillariae gen. nov., sp. nov., a novel genus of the family Microbacteriaceae. (1/7)
Okibacterium fritillariae gen. nov., sp. nov. (type strain VKM Ac-2059T = IFO 16404T) is proposed for aerobic, oxidase- and catalase-positive, coryneform bacteria isolated from seeds of Fritillaria ruthenica Wikstr. and Clematis recta L. Strains of the new genus form a distinct branch within the phylogenetic cluster composed of members of the family Microbacteriaceae and are characterized by B-type peptidoglycan containing amino acids glycine, glutamate, homoserine, alanine and lysine, the glycolyl type of muramic acid, the major menaquinones MK-10 and MK-11, the principal phospholipids phosphatidylglycerol and diphosphatidylglycerol, and a DNA G+C content of approximately 67 mol %. (+info)New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities. (2/7)
Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity. (+info)Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells. (3/7)
The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA. (+info)Puqienine F, a novel veratramine alkaloid from the bulbs of Fritillaria puqiensis. (4/7)
A novel veratramine alkaloid, called puqienine F (1) and possessing a 12,16-epoxy ring, was isolated from the bulbs of Fritillaria puqiensis G. D. Yu et G. Y. Chen (Liliaceae). The structure was elucidated by extensive spectral and X-ray crystallographic analyses. (+info)Diverse retrotransposon families and an AT-rich satellite DNA revealed in giant genomes of Fritillaria lilies. (5/7)
(+info)Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis. (6/7)
The new kaurane diterpene, ent-3beta-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). All the isolates showed neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. (+info)Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells. (7/7)
Fritillaria ussuriensis (FU, derived from the bulbs of various species of the genus Fritillaria, including Fritillaria thunbergii Miq.) is used in herbal medicine to treat conditions such as eczema, skin burns, and frostbite. In this study, we investigated the mechanism of the anti-allergy effect of FU. FU extract (80 mg/kg), orally administered to Sprague-Dawley (SD) rats, significantly inhibited the passive cutaneous anaphylaxis (PCA) reaction. It inhibited the compound 48/80-induced release of histamine from rat peritoneal mast cells in a concentration-dependent manner. Significant inhibitory effects of the FU extract on IL-6, IL-8, and TNF-alpha (1, 10, and 100 microg/mL) were observed in HMC-1 cells. Treatment with FU attenuated PMA plus A23187-induced phosphorylation of all three MAPKs, especially at concentrations of 10 and 100 microg/mL. Further, it (80 mg/kg) led to significant inhibition of mast-cell accumulation in ear tissue at the chronic phase. These results indicate that it inhibits allergic reactions. (+info)"Fritillaria" is a genus of plants that includes around 140 species, many of which have been used in traditional medicine for various purposes. In a medical context, "Fritillaria" usually refers to the bulbs of certain Fritillaria species, such as Fritillaria cirrhosa and Fritillaria thunbergii, which are used in Traditional Chinese Medicine (TCM).
In TCM, Fritillaria bulbs are known as "Beimu" or "Chuanbei," and they have been used to treat respiratory conditions such as coughs, bronchitis, and asthma. The active components of Fritillaria include alkaloids, steroidal saponins, and polysaccharides, which are believed to have anti-inflammatory, expectorant, and antitussive effects.
However, it's important to note that the use of Fritillaria in medicine is not well-studied in Western medicine, and its effectiveness and safety are not established. Moreover, some Fritillaria species contain toxic compounds, so it's essential to consult a healthcare professional before using any Fritillaria products for medicinal purposes.
I am not aware of a medical term called "Cevanes." It is possible that there may be a typo or misspelling in the term you provided. If you have more context about where this term was used, I can try to provide more information or help with finding a correct definition.
An "AT-rich sequence" in genetics refers to a region within DNA or RNA that has a high concentration of adenine (A) and thymine (T) base pairs. In DNA, adenine pairs with thymine via two hydrogen bonds, whereas cytosine (C) pairs with guanine (G) via three hydrogen bonds. Therefore, AT-rich sequences tend to have lower melting temperatures (the temperature at which the double-stranded structure separates into single strands) compared to GC-rich sequences. This property is exploited in various molecular biology techniques such as polymerase chain reaction (PCR), where increasing the AT content can lower the annealing temperature and make the reaction more efficient. However, AT-rich regions can also pose challenges in sequencing and assembly of genomic data due to their repetitive nature and lower complexity.