Garcinia mangostana
Phytochemicals
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. (1/33)
The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated. The present study was undertaken to examine the effects of mangosteen extracts (100% ethanol, 70% ethanol, 40% ethanol and water) on histamine release and prostaglandin E2 synthesis. We found that the 40% ethanol extract of mangosteen inhibited IgE-mediated histamine release from RBL-2H3 cells with greater potency than the water extract of Rubus suavissimus that has been used as an anti-allergy crude drug in Japan. All extracts of mangosteen potently inhibited A23187-induced prostaglandin E2 synthesis in C6 rat glioma cells, while the water extract of Rubus suavissimus had no effect. The 40% ethanol extract of mangosteen inhibited the prostaglandin E2 synthesis in a concentration-dependent manner with relatively lower concentrations than the histamine release. In addition, passive cutaneous anaphylaxis (PCA) reactions in rats were significantly inhibited by this ethanol extract as well as by the water extract of Rubus suavissimus. These results suggest that the 40% ethanol extract of mangosteen has potent inhibitory activities of both histamine release and prostaglandin E2 synthesis. (+info)Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. (2/33)
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds. (+info)Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat. (3/33)
The purpose of this study was to examine whether crude alpha-mangostin (a major xanthone derivative in mangosteen pericarp (Garcinia mangostana)) has short-term chemopreventive effects on putative preneoplastic lesions involved in rat colon carcinogenesis. The crude preparation was obtained by simple recrystallization of an ethylacetate extract of mangosteen pericarps. A total of 33 five-week-old male F344 rats were randomly divided into 5 experimental groups. Rats in groups 1-3 were given a subcutaneous injection of 1,2-dimethylhydrazine (DMH)(40 mg/kg body weight) once a week for 2 weeks. Starting one week before the first injection of DMH, rats in groups 2 and 3 were fed a diet containing 0.02% and 0.05% crude alpha-mangostin, respectively, for 5 weeks. Rats in group 4 also received the diet containing 0.05% crude alpha-mangostin, while rats in group 5 served as untreated controls. The experiment was terminated 5 weeks after the start. Dietary administration of crude alpha-mangostin at both doses significantly inhibited the induction and/or development of aberrant crypt foci (ACF) (P<0.05 for 0.02% crude alpha-mangostin, P<0.01 for 0.05% crude alpha-mangostin), when compared to the DMH-treated group (group 1). Moreover, treatment of rats with 0.05% crude alpha-mangostin significantly decreased dysplastic foci (DF) (P<0.05) and beta-catenin accumulated crypts (BCAC) (P<0.05), to below the group 1 values. The proliferating cell nuclear antigen (PCNA) labeling indices of colon epithelium and focal lesions in groups 2 and 3 were also significantly lower than in group 1 and this effect occurred in a dose dependent manner of the crude alpha-mangostin. This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development. (+info)Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. (4/33)
(+info)Pichia garciniae sp. nov., isolated from a rotten mangosteen fruit (Garcinia mangostana L., Clusiaceae). (5/33)
(+info)Validation of LC for the determination of alpha-mangostin in mangosteen peel extract: a tool for quality assessment of Garcinia mangostana L. (6/33)
Mangosteen, Garcinia mangostana L., is known as the "Queen of fruits" and can be cultivated in the tropical rainforest such as Malaysia, Indonesia, and Thailand. Compounds isolated from the fruit peel of mangosteen contain abundant xanthones (especially alpha-mangostin). It has been used as traditional medicine such as anti-inflammatory and antibacterial and is popularly applied to cosmetic and pharmaceutical products. However, there is little information for quality and quantity determination of alpha-mangostin in mangosteen. Thus, the aim of this study was to set up a validated and stability-indicated isocratic reverse-phase high-performance liquid chromatographic (HPLC) method for quality control and quantity determination of a-mangostin from mangosteen peel extract. The assay was fully validated and shown to be linear (r(2) > 0.999), sensitive (LOD = 0.02 microg/mL and LOQ = 0.08 microg/mL), accurate (intra-day was between 98.1-100.8%, inter-day was between 90.0-101.3%), precise (intra-day variation < or = 1.8%, inter-day variation < or = 4.3%), specific, and with good recovery. Total analysis was approximately 8 min. The finalized method is also a stability-indicating assay. The present method should be useful for analytical research and for routine quality control analysis of alpha-mangostin in mangosteen peel extract and products of mangosteen. (+info)Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. (7/33)
(+info)In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract. (8/33)
(+info)Garcinia mangostana, also known as the mangosteen, is not a medical term but rather the name of a tropical evergreen tree that grows in Southeast Asia, Southwest India, and other tropical regions. The tree produces a purple, edible fruit that has been used in traditional medicine for various purposes.
In modern medical research, there has been some interest in the potential health benefits of Garcinia mangostana extracts, particularly in relation to weight loss and anti-inflammatory effects. However, more research is needed to confirm these potential benefits and establish recommended dosages and safety guidelines. It's important to consult with a healthcare provider before starting any new supplement regimen.
Xanthones are a type of chemical compound that are found in various plants and fruits. They have a variety of potential health benefits, including anti-inflammatory, antioxidant, and anticancer properties. Some research suggests that xanthones may help to protect against chronic diseases such as heart disease and cancer, but more studies are needed to confirm these effects. Xanthones can be found in small amounts in a variety of foods, including mangosteen fruit, blackberries, and turmeric. They are also available in supplement form.
Garcinia is a genus of flowering plants in the family Clusiaceae. It includes several species that are used in traditional medicine and as dietary supplements. One of the most well-known species is Garcinia cambogia, also known as Malabar tamarind, which contains hydroxycitric acid (HCA) in its fruit rind. HCA is a chemical that has been promoted as a weight loss aid, although its effectiveness is still a matter of scientific debate.
It's important to note that while some Garcinia species have potential health benefits, they can also have side effects and interact with certain medications. Therefore, it's always recommended to consult with a healthcare provider before starting any new supplement regimen.
Phytochemicals are compounds that are produced by plants (hence the "phyto-") for their own defense against predators and diseases. They are found in various plant parts such as fruits, vegetables, grains, legumes, nuts, and teas. Phytochemicals can have beneficial effects on human health as they exhibit protective or disease preventive properties.
These compounds belong to a diverse group with varying structures and chemical properties. Some common classes of phytochemicals include carotenoids, flavonoids, phenolic acids, organosulfides, and alkaloids. They have been shown to possess antioxidant, anti-inflammatory, anti-cancer, and immune system-enhancing properties, among others.
It is important to note that while phytochemicals can contribute to overall health and wellness, they should not be considered a cure or treatment for medical conditions. A balanced diet rich in various fruits, vegetables, and whole foods is recommended for optimal health benefits.
I'm sorry for any confusion, but "fruit" is not a medical term per se. It is a common term used to describe the part of a plant that develops from the ovary after flowering and contains seeds. However, in a nutritional or dietary context, "fruits" are often referred to as foods that are typically sweet and juicy, and come from plants' flowers. They are rich in fiber, vitamins, and minerals, making them an essential part of a healthy diet. But in a strict medical sense, there isn't a specific definition for "fruit."
A plant extract is a preparation containing chemical constituents that have been extracted from a plant using a solvent. The resulting extract may contain a single compound or a mixture of several compounds, depending on the extraction process and the specific plant material used. These extracts are often used in various industries including pharmaceuticals, nutraceuticals, cosmetics, and food and beverage, due to their potential therapeutic or beneficial properties. The composition of plant extracts can vary widely, and it is important to ensure their quality, safety, and efficacy before use in any application.
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Extract12
- A major xanthone, α -mangostin, is rich in the G. mangostana fruit rind extract [ 4 ]. (hindawi.com)
- reported that repeated oral supplementation of an ethanol extract of G. mangostana fruit rind for twenty-eight days did not show systemic toxicity in Sprague Dawley rats, which concluded its safety for human consumption [ 9 ]. (hindawi.com)
- Garcinia Mangostana Powder can be stacked with Sphaeranthus Indicus Extract. (lifelabsupplements.com)
- What is Garcinia Mangostana (Mangosteen) Peel Extract? (paulaschoice.co.uk)
- To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.METHODS:Anatomical characterization and histochemical reactions were performed for structural identification and the presence of phytocompounds. (unifesp.br)
- This experimental study was conducted to assess the general safety of Garcinia mangostana Linn microparticle extract on BALB/c mice renal function after 14 days of administration. (ui.ac.id)
- In this experimental study, the microparticles of G. mangostana extract were wrapped in chitosan alginate capsules to reach the target organ effectively. (ui.ac.id)
- G. mangostana extract did not affect renal weight. (ui.ac.id)
- The extract G. mangostana Linn is secure until 2 g/kg BW of dose for 14 days of administration on BALB/c mice. (ui.ac.id)
- The chloroform and ethyl acetate extract of G. mangostana showed very potent activities. (upm.edu.my)
- Effect of taking mangosteen peel extract (Garcinia mangostana L.) supplement on gingival inflammation in fixed orthodontic patients (A study of leukocyte count of gingival crevicular fluid). (ugm.ac.id)
- The conclusion of this study is the consumption of mangosteen peel extract (Garcinia mangostana L) supplement signicantly influences the reduction of gingival inflammation in patients with fixed orthodontic appliances, evident from the decline in the leukocyte counts of gingival crevicular fluids. (ugm.ac.id)
Manggis6
- Kulit manggis ( Garcinia mangostana L ) mengandung xantone yang memiliki sifat antiinflamasi. (ugm.ac.id)
- Maka, diperlukan alternatif lain, seperti pemanfaatan kulit buah manggis ( Garcinia mangostana Linn) yang mempunyai kandungan xanthone yang merupakan kelompok polifenol yang memiliki efek anti bakteri. (ub.ac.id)
- Ekstrak kulit manggis ( G. mangostana ) diketahui bersifat bakteriosidal terhadap bakteri P. fluorescens. (ub.ac.id)
- Karena kulit manggis ( G. mangostana ) mengandung xanthone yang merupakan kelompok polifenol. (ub.ac.id)
- Tujuan: Mengetahui daya hambat ekstrak kulit buah manggis (Garcinia mangotana L.) terhadap pertumbuhan Candida albicans secara in vitro. (umi.ac.id)
- Kulit Buah Manggis (Garcinia mangostana L.), Candida albicans, zona daya hambat. (umi.ac.id)
Linn1
- These results designate that microencapsulation of G. mangostana Linn increases BUN and creatinine if given at 2 g/kg BW dose for 14 days on male mice. (ui.ac.id)
Xanthone1
- Four types of crude extracts were obtained from the stem bark of Garcinia mangostana from which six xanthone derivatives: α-mangostin, β-mangostin, garcinone D, mangostenol, fuscaxanthone C and dulcisxanthone F were isolated. (upm.edu.my)
Mangosteens2
- Evaluation of Fruit Characters, Xanthones Content, and Antioxidant Properties of Various Qualities of Mangosteens (Garcinia mangostana L. (ipb.ac.id)
- 2017). Evaluation of Fruit Characters, Xanthones Content, and Antioxidant Properties of Various Qualities of Mangosteens (Garcinia mangostana L.). Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) , 38 (3). (ipb.ac.id)
Extracts3
- This proprietary herbal composition contains the extracts of the Garcinia mangostana fruit rind (GM) and the Cinnamomum tamala leaf (CT). (hindawi.com)
- it contains aqueous-ethanol extracts of the Garcinia mangostana fruit rind (GM) and Cinnamomum tamala leaf (CT). (hindawi.com)
- Extracts of two herbs - Sphaeranthus indicus and Garcinia mangostana - were found to be effective and combined in Meratrim in a 3:1 ratio. (healthline.com)
Indicus1
- Meratrim is a blend of two herbs - Sphaeranthus Indicus and Garcinia mangostana . (healthline.com)
Fruit4
- Despite extensive use of various preparations of G. mangostana fruit rind or C. tamala leaves as medicine or food, the toxicological evaluations of GMCT are vital to establish its safety for human use. (hindawi.com)
- Garcinia Mangostana Powder can be taken by adding the recommended dose to drinks such as water or fruit juice, or by placing the recommended dose into empty capsules and swallowed. (lifelabsupplements.com)
- Garcinia mangostana, also known as mangosteen, is a fruit from Southeast Asia that is known for its health benefits such as anti-inflammatory, antihypertensive, and anticancer properties. (uconn.edu)
- Mangosteen is a tropical plant, technically known as Garcinia mangostana L. The fruit is round and is dark to red purple, smooth on the outside. (mendosa.com)
Calophyllum2
- Numerous species in Calophyllum , Clusia Linnaeus, and Garcinia produce valuable commercial resin or gum. (efloras.org)
- Other species, such as Calophyllum inophyllum and Garcinia indica Choisy, have oily seeds. (efloras.org)
Southeast Asia2
- For generations, the indigenous communities of Southeast Asia have turned to Garcinia Mangostana Powder as a traditional solution for managing a wide array of health concerns. (lifelabsupplements.com)
- Mangosteen (Garcinia mangostana) is a plant that grows in Southeast Asia. (medlineplus.gov)
Dose1
- A typical dose of Garcinia Mangostana Powder ranges from 500mg - 1000mg per day. (lifelabsupplements.com)
Natural2
- Our Garcinia Mangostana is used in various industries and has effectiveness, natural properties, and long-shelf life, making it the first choice of everyone. (mentholcristales.com)
- Our trained and professional experts are our backbone and never mind putting extra effort into bringing the most advanced Garcinia Mangostana with natural goodness. (mentholcristales.com)
Side Effects1
- Side effects of Garcinia Mangostana can include Lactic Acidosis. (lifelabsupplements.com)
Makes1
- Our experts keep strict surveillance on the grade standard of our Garcinia Mangostana that makes us the talk of the town. (mentholcristales.com)
Produce1
- Our experts have done deep research and analyzed every aspect of the Garcinia Mangostana to produce it according to industry norms. (mentholcristales.com)
Work1
- We work on our toes to formulate the Garcinia Mangostana according to your industry needs. (mentholcristales.com)
Rich1
- Furthermore, Garcinia Mangostana is a rich source of Vitamin C , providing a valuable supply of this vital nutrient. (lifelabsupplements.com)
Mangosteen21
- The origin of cultivated mangosteen (Garcinia mangostana L. var. (cgiar.org)
- Mangosteen (Garcinia mangostana var. (cgiar.org)
- The Amazon region presents favorable edaphoclimatic conditions for development of production systems with tropical fruits, among the species of economic interest the mangosteen (Garcinia mangostana L.) has been highlighted, due to interest of national and international consumer markets. (scirp.org)
- Click here to be notified by email when Mangosteen Powder Pericarp 8 oz Garcinia Mangostana becomes available. (gonutra.com)
- Effect of different solvents on recovery of total monomeric anthocyanin from mangosteen peel (Garcinia mangostana L. (chemijournal.com)
- Effect of different solvents on recovery of total monomeric anthocyanin from mangosteen peel ( Garcinia mangostana L.). Int J Chem Stud 2020;8(1):09-11. (chemijournal.com)
- This investigates the possibility of a natural dye between Garcinia mangostana (Mangosteen) and Selenicereus guatamalensis (Dragon Fruit) extracts. (ajbls.com)
- The rind of the mangosteen (Garcinia mangostana L.) contains many xanthones which have anti-infl ammatory and antioxidant activity that can counteract free radicals and prevent or inhibit cell degeneration (inhibiting aging). (univpancasila.ac.id)
- 2. Structure activity relationship of xanthones for inhibition of Cyclin Dependent Kinase 4 from mangosteen (Garcinia mangostana L. (nih.gov)
- 3. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. (nih.gov)
- 4. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). (nih.gov)
- 6. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. (nih.gov)
- 8. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). (nih.gov)
- 9. Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana linn. (nih.gov)
- 16. Inhibition of CHOP accentuates the apoptotic effect of α-mangostin from the mangosteen fruit (Garcinia mangostana) in 22Rv1 prostate cancer cells. (nih.gov)
- 19. Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells. (nih.gov)
- Mangosteen ( Garcinia mangostana ) is an exotic, tropical fruit with a slightly sweet and sour flavor. (healthline.com)
- Corrigendum to "Capillary Water in Pericarp Enhances Hypoxic Condition during On-Tree Fruit Maturation That Induces Lignification and Triggers Translucent Flesh Disorder in Mangosteen (Garcinia mangostana L. (hindawi.com)
- S. Noichinda, K. Bodhipadma, and S. Kong-In, "Capillary water in pericarp enhances hypoxic condition during on-tree fruit maturation that induces lignification and triggers translucent flesh disorder in mangosteen ( Garcinia mangostana L.)," Journal of Food Quality , vol. 2017, Article ID 7428959, 7 pages, 2017. (hindawi.com)
- The Mangosteen (Garcinia mangostana), colloquially known simply as 'the mangosteen', is a tropical evergreen tree, believed to have originated in the Sunda Islands and the Moluccas of Indonesia. (ecplaza.net)
- A variety of local favourites such as the mangosteen ( Garcinia mangostana ) and the cempedak ( Artocarpus integer ) can be seen as you walk towards Jacob Ballas Children's Garden from the Herb and Spice Garden. (nparks.gov.sg)
Camellia Sinensis1
- Whether you are looking for Peppermint Oil, Camellia Sinensis, Clove Oil, Garcinia Cambogia, Jojoba Oil, Tea Tree Oil, Trifla, Tribulus Terrestris or Eucalyptus Oil In Thailand , we are the one-stop to find unparalleled quality as promised. (mentholcrystals.net)
Mangostin2
- 14. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. (nih.gov)
- 20. Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G. (nih.gov)
Xanthones2
Cambogia1
- So, products and solutions are another person tired of messing the particular diet pills and goods that can harm you or those that can cause an associated with side effects, it 's time to perform the smart thing and take Garcinia cambogia. (in2p3.fr)
Species1
- A common name for some Garcinia species, derived from a corruption of the word Cambodia, where the plant is found. (bvsalud.org)
Potential1
- 18. Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line. (nih.gov)