Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis. (1/6)
This study was carried out to determine the effects of the 70% ethanolic extract from the anomalous fruits of Gleditsia sinensis LAM. (AFGS) on experimental allergic reactions and inflammation. AFGS (200, 500, 1000 mg/kg, p.o.) dose-dependently inhibited the systemic anaphylactic shock induced by compound 48/80 in mice and cutaneous reactions induced by histamine or serotonin in rats. At doses of 500 and 1000 mg/kg, AFGS showed a clear inhibition on homologous passive cutaneous anaphylaxis in rats. In vitro, AFGS significantly reduced histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 20 and 50 micro/ml. Moreover, AFGS (500, 1000 mg/kg, p.o.) showed a significant inhibition on the hind paw edema in rats and ear swelling in mice caused by carrageenin and croton oil, respectively. It also clearly inhibited the vascular permeability induced by acetic acid in mice at a dose of 1000 mg/kg. These findings demonstrate that the ethanolic extract from the anomalous fruits of Gleditsia sinensis possesses antiallergic and anti-inflammatory activities, which may be mediated by reducing the release of mediators such as histamine from mast cells and weakening the inflammatory action of these mediators. (+info)Inhibition of experimental allergic rhinitis by the n-butanol fraction from the anomalous fruits of Gleditsia sinensis. (2/6)
This study was conducted to clarify the effect of the n-butanol fraction from the anomalous fruits of Gleditsia sinensis LAM. (NBGS) on experimental allergic rhinitis. NBGS (100, 200, 400 mg/kg, p.o.) dose-dependently inhibited nasal symptoms (sneezing and nasal rubbing) and dye leakage induced by antigen challenge into the nasal cavity of actively sensitized rats. Significant effects were observed at doses of 200 and 400 mg/kg. NBGS (200, 400 mg/kg) also showed a clear inhibition of sneezing and an inhibitory tendency on nasal rubbing induced by histamine in normal rats. At 400 mg/kg, it significantly reduced dye leakage induced by histamine into the nasal cavity of rats. Terfenadine (10 mg/kg, p.o.), an antihistaminic drug, clearly inhibited the nasal symptoms and the amount of dye leakage induced by antigen or histamine. Furthermore, NBGS significantly reduced in vitro histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 30 and 100 microg/ml. These results suggest that NBGS may be clinically effective in alleviating the nasal symptoms of allergic rhinitis, probably by inhibiting both histamine release from mast cells and nasal vascular permeability. (+info)Antimutagenic constituents from the thorns of Gleditsia sinensis. (3/6)
Antimutagenic activity-guided fractionation of an extract prepared from the thorns of Gleditsia sinensis LAM. led to the isolation of one triterpenoid and four steroids, which were identified as D:C-friedours-7-en-3-one (1), stigmast-4-ene-3,6-dione (2), stigmastane-3,6-dione (3), stigmasterol (4), and beta-sitosterol (5). Triterpenoid 1 was found for the first time in a natural source and the steroids 2-5 were first isolated from this plant. Stigmasterol was the most active antimutagen, showing 51.2% and 64.2% reduction of the induction factor against the mutagens MNNG and NQO, respectively, in the SOS chromotest. Some NMR data of the steroids 2 and 3 obtained have to be revised. (+info)Alleviation of picryl chloride-induced delayed type hypersensitivity reaction by saponin fraction of Gleditsia sinensis. (4/6)
The objective of the present study was to investigate the effects of saponin fraction from anomalous fruits of Gleditsia sinensis (SFGS) on picryl chloride-induced delayed type hypersensitivity (PC-DTH) and functions of T lymphocytes and macrophages in mice. SFGS (100, 200 mg/kg), orally administered during either sensitization stage or effector stage, produced remarkable inhibition of PC-DTH. In vitro, SFGS (1, 2, 4 microg/ml) concentration-dependently attenuated concanavalin A (Con A)-elicited mouse splenocyte proliferation and interleukin 2 (IL-2) production. At concentrations of 10 and 20 microg/ml, SFGS inhibited lipopolysaccharide (LPS)-induced production of nitric oxide and interleukin 1beta (IL-1beta) of mouse peritoneal macrophages. The findings indicate that SFGS attenuates PC-DTH in mice, which is probably mediated by preventing proliferation and differentiation of T cells during the sensitization stage and suppressing activation of macrophages during the effector stage. (+info)Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo. (5/6)
(+info)Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns. (6/6)
Angiogenesis, the process of new vessel formation from the pre-existing blood vasculature, is critical for continuous tumor growth and is considered to be a validated antitumor target. The results of our previous study demonstrate the anti-angiogenic potential of an extract of Gleditsia sinensis thorns, which has been traditionally used in Korean medicine to remedy diverse diseases, including tumors. In the present study, we attempted to identify the active anti-angiogenic constituents of the ethanol extract of G. sinensis thorns (EEGS). By virtue of in vitro activity-guided fractionation using human umbilical vein endothelial cells (HUVEC) primary endothelial cells, chromatographic separation, and NMR spectral analyses, we isolated and identified the potent active constituent, cytochalasin H, a biologically active secondary metabolite of fungi. This unexpected active constituent may have originated from the endophytic fungi, Chaetomium globosum, which naturally populate G. sinensis, the identity of which was determined by analysis of fungal community. Cytochalasin H isolated from the EEGS showed in vitro anti-angiogenic activities such as suppressed cell growth and mobility in HUVEC, and inhibited the pro-angiogenic protein-induced formation of new blood vessels in vivo. The anti-angiogenic effect of cytochalasin H was in part due to reduced expression of pro-angiogenic factor, such as endothelin-1. This is the first report regarding the isolation and identification of cytochalasin H, as an active anti-angiogenic constituent of G. sinensis thorns. (+info)"Gleditsia" is a genus of flowering plants in the legume family, Fabaceae. It includes several species of trees that are native to North America and Asia. The most common species is Gleditsia triacanthos, also known as the honey locust. This tree is known for its long, hanging pods that contain sweet, edible pulp.
In a medical context, "Gleditsia" is not commonly used as a term. However, the bark of the honey locust tree has been used in traditional medicine to treat various ailments such as skin conditions, fever, and digestive problems. The active compounds found in the bark include tannins, saponins, and flavonoids, which have anti-inflammatory, antimicrobial, and antioxidant properties.
It is important to note that while some natural remedies made from "Gleditsia" species may have potential health benefits, they should not be used as a substitute for professional medical advice or treatment. It is always recommended to consult with a healthcare provider before using any alternative or complementary therapies.
Gleditsia - Wikipedia
Gleditsia fera in Chinese Plant Names @ efloras.org
Gleditsia triacanthos
Gleditsia sinensis - Chinese Honey Locust - Seeds
Gleditsia Plants: Information & Pictures
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Honeylocust1
- Caspian locust or Persian honeylocust Gleditsia fera (Lour. (wikipedia.org)
Fabaceae1
- Gleditsia /ɡlɪˈdɪtsiə/ (honey locust) is a genus of trees in the family Fabaceae, subfamily Caesalpinioideae, native to the Americas and Asia. (wikipedia.org)
Genus3
- Gymnocladus is a sister genus of Gleditsia, and it too mimicked this dispersion pattern, except it came to the Americas much earlier. (wikipedia.org)
- Though there are no extant European Gleditsia species, there are fossils found in Europe which could mean that the genus also crossed the North Atlantic land bridge. (wikipedia.org)
- Gleditsia amorphoides is the most basal of the genus, most closely related to G. sinensis but not the North American species (G. aquatica and G. triacanthos). (wikipedia.org)
Sinensis2
- Japanese honey locust Gleditsia medogensis Z.C.Ni Gleditsia microphylla D.Gordon ex Y.T.Lee Gleditsia rolfei S.Vidal Gleditsia sinensis Lam. (wikipedia.org)
- Gleditsia sinensis is one of the 50 fundamental herbs used in Chinese herbology, where it is called zào jiá (皂荚). (wikipedia.org)
Aquatica1
- Taubert Gleditsia aquatica Marshall - water locust or swamp locust Gleditsia assamica Bor Gleditsia australis F. B. Forbes & Hemsley Gleditsia caspica Desf. (wikipedia.org)
Honey3
- Chinese honey locust Gleditsia triacanthos L. - thorny honey locust Hybrids Gleditsia × texana Sarg. (wikipedia.org)
- Look no further than the Gleditsia triacanthos, commonly known as the Honey Locust. (sheffields.com)
- The Honey Locust, scientifically known as Gleditsia triacanthos, is a deciduous tree native to North America. (nativeforestnursery.com)
Rolfei1
- The records of Gleditsia rolfei S. Vidal from Taiwan (Fl. (efloras.org)
Caspica1
- Three previously undescribed oleanane-type triterpenoidal saponins named caspicaosides L-N were isolated from the fruits of Gleditsia caspica Desf. (elsevierpure.com)
Japonica2
- Gleditsia japonica Miq. (wikipedia.org)
- Photo: Gleditsia japonica 1. (henriettes-herb.com)
Lour1
- Gleditsia fera (Lour. (efloras.org)
Cultivars1
- Gleditsia is a legume tree, very characteristic for its turfs of thorns growing straight from the trunk and branches of the tree, but there are thornless cultivars (Gleditsia triacanthos var. (aranyaani.in)
Bark1
- Bark from twigs of Gleditsia triacanthos was used in form of infusions by Delaware Indians as a cough remedy and to cleanse blood. (aranyaani.in)
Plants2
- citation needed] Gleditsia L. Plants of the World Online. (wikipedia.org)
- 02725000 Don Gordon 1966 THE NEW YORK BOTANICAL GARDEN PLANTS of THE "MANUAL RANGE'» Bottom-land of the Mississippi River» Columbus, Kentucky, June 38* Collected by H. A. Gleason, 1940 Gleditsia aquatic* Harsh. (nybg.org)
Species1
- There are 12 species: Gleditsia amorphoides (Griseb. (wikipedia.org)
Plant1
- Need not worry with this Gleditsia artificial hanging plant. (nearlynatural.com)
Trees1
- Gleditsia are proven as hardy street and shade trees, being fast-growing, heat and drought tolerant and well-suited for the demands of urban environments. (torbaytreefarmers.com)
Leaves1
- An overflow of Gleditsia leaves spill from a hanging basket for a fresh from the jungle look. (nearlynatural.com)
Inermis1
- GLEDITSIA triacanthos f. inermis Street Keeper® - This cultivar boasts the tight, narrow form that has been lacking in urban tolerant Honeylocust. (klynnurseries.com)
Sunburst1
- Gleditsia triacanthos Sunburst is a Golden variety of Honey Locust , with glorious golden-yellow new leaf fronds, made up of fern-like rows of little leaflets that seem to sniff the breeze as they sway about. (ashridgetrees.co.uk)
Thornless1
- Last year, the failing London Plane trees on the north side of North Dr. were replaced with thornless honeylocusts ( Gleditsia triacanthos var. (nih.gov)
Seedless1
- The composition of n-butanol fraction of Gleditsia triacanthos methanolic seedless fruit extract was identified from the LC-ESI/MS/MS spectra. (phcogj.com)
Marshall1
- Gleditsia spinosa Marshall, Arbust. (usf.edu)
Native2
- Gleditsia are native to America and parts of Asia, and have been widely planted in Britain since the start of the 1700's. (ashridgetrees.co.uk)
- Gleditsia triacanthos is deciduous and native to North America. (leafland.co.nz)
Tree1
- The most spectacular is a large Gleditsia tree. (mooseyscountrygarden.com)
Asia1
- The theory is that Gleditsia originated in East Asia in the Eocene, crossed the land bridge across the North Pacific Ocean into North America, and then spread down to South America millions of years later. (wikipedia.org)