Granuloma Annulare
Necrobiosis Lipoidica
Granuloma
Subcutaneous Tissue
Histiocytes
Scalp
Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration. (1/34)
Accumulation of inflammatory cells such as macrophages may lead to degeneration of connective tissue matrix in various skin diseases. Macrophage metalloelastase, is a matrix metalloproteinase (MMP-12) capable of degrading elastin as well as various basement membrane components. To investigate the role of human macrophage metalloelastase in skin, we assessed by in situ hybridization and immunohistochemistry 66 specimens representing skin diseases characterized either by changes in elastic fibers or by pronounced infiltrations of extravasating and migrating macrophages. CD68 immunostaining was performed to identify the human macrophage metalloelastase-positive cells and Weigert's Resorcin-Fuchsin staining to reveal the status of elastic fibers. We found abundant expression of human macrophage metalloelastase mRNA in macrophages in areas devoid of normal elastic fibers in granulomatous skin diseases sarcoidosis, necrobiosis lipoidica diabeticorum, and granuloma annulare. Positive cells for human macrophage metalloelastase protein could be detected in the same regions as well as positive immunostaining for urokinase plasminogen activator. Of the other matrix metalloproteinases capable of degrading elastin, 92 kDa gelatinase colocalized with human macrophage metalloelastase, while 72 kDa gelatinase was produced by surrounding fibroblast-like cells. Furthermore, human macrophage metalloelastase was expressed by macrophages in areas with disrupted basement membrane, as assessed by type IV collagen staining, in pityriasis lichenoides and dermatitis herpetiformis. Specimens of anetoderma, acrodermatitis chronica atrophicans and pseudoxanthoma elasticum showed no signal for human macrophage metalloelastase. Matrilysin was not detected in any of the samples investigated. Our study suggests that human macrophage metalloelastase may contribute to elastin degradation occurring in granulomatous skin diseases and may aid macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders. (+info)Penile granuloma annulare. (2/34)
A case of granuloma annulare (GA) localised to the shaft of the penis is reported with a brief review of the current literature. We concluded that penile GA, although rare, should be considered in the differential diagnosis of granulomatous lesions of the penis and that histopathological examination of the lesion is essential for the diagnosis. (+info)Papulonecrotic tuberculide and stenosis of the abdominal aorta. (3/34)
Papulonecrotic tuberculide (PNT) is a rare form of skin tuberculosis affecting predominantly young adults, with a history of immunity to Mycobacterium tuberculosis. We report a case of a young Caucasian female with PNT who was also documented to have a stenotic segment in the abdominal aorta. The difficulty in clarifying and treating the primary disease and the association between a tuberculous infection and Takayasu's arteritis are discussed. (+info)Subcutaneous granuloma annulare of the extremities in children. (4/34)
OBJECTIVE: To familiarize surgeons to the natural history and treatment of granuloma annulare of the extremities in children. DESIGN: Case review and follow-up by appointment and questionnaire. SETTING: The Children's Hospital of Eastern Ontario, a tertiary referral centre. PATIENTS: Twenty-seven children (23 girls, 4 boys) seen between 1983 and 1998 with subcutaneous granuloma annulare, proven pathologically. The mean age at initial presentation was 8.3 years (range from 1.8 years to 16.7 years). The mean follow-up was 45 weeks (range from 1 week to 5 years). INTERVENTION: Biopsy excision of the lesions. OUTCOME MEASURES: The incidence multiple lesions, the commonest site of occurrence and the incidence of recurrence. RESULTS: Six children presented with multiple lesions for a total of 46 lesions. The anterior pretibial area was the most frequently affected site (16 lesions), followed by the ankle (6 lesions) and the long finger (4 lesions). Five patients suffered recurrence of the lesion, with a total of 7 lesions recurring. CONCLUSIONS: Subcutaneous granuloma annulare is a benign inflammatory skin lesion occurring most frequently in the anterior pretibial area in children, predominantly girls. The incidence of recurrence and of multiple lesions is high. Biopsy is required for definitive diagnosis. The lesion resolves spontaneously without treatment. (+info)Treatment of disseminated granuloma annulare with fumaric acid esters. (5/34)
BACKGROUND: Granuloma annulare is a granulomatous disease of unknown etiology. Various therapies have been tried in disseminated granuloma annulare (DGA), including corticosteroids, several variants of psoralen plus ultraviolet-A radiation, ultraviolet- A1 radiation, systemic retinoids, and dapsone, with variable success. We report a patient with recalcitrant DGA who was treated with fumaric acid esters (FAE). CASE PRESENTATION: A 40-year old Caucasian woman presented with a 25-year history of recalcitrant DGA. On both legs and the abdomen there were erythematous annular plaques. She was treated with FAE in tablet form using two formulations differing in strength (low strength tablets: 30 mg dimethylfumarate, 67 mg monoethylfumarate Ca salt, 5 mg monoethylfumarate Mg salt, 3 mg monoethylfumarate Zn salt; high strength tablets: 120 mg dimethylfumarate, 87 mg monoethylfumarate Ca salt, 5 mg monoethylfumarate Mg salt, 3 mg monoethylfumarate Zn salt). After three-month therapy, an almost complete clearance of skin lesions was achieved. With the exception of temporary lymphopenia, no adverse effects were observed. The patient remained in remission during a six-month follow up period. CONCLUSIONS: Our observation has demonstrated that FAE is a potentially beneficial therapeutic option for patients with recalcitrant DGA. However controlled trials are necessary to fully explore the efficacy, optimal dosage, and safety of FAE in the management of DGA. (+info)T-cell receptor repertoire and cytokine pattern in granuloma annulare: defining a particular type of cutaneous granulomatous inflammation. (6/34)
Granuloma annulare is a common granulomatous infiltration of the skin of unknown etiopathogenesis. We analyzed granuloma annulare biopsies in 11 patients and could find in all patients significant numbers of CD4-T cells. These cells showed a broad usage of the different T cell receptor Vbeta families and a rather unbiased repertoire when the complementary determining region 3 spectra were analyzed by the Immunoscope technique. Comparison with the peripheral blood mononuclear cell repertoire, however, identified in all patients few skin-specific expansions, which were for one patient also present in two distinct skin sites. Extensive sequence analysis of the complementary determining region 3 region confirmed the presence of a limited number of skin-specific expansions together with various nonspecific T cell infiltrations. Analysis of the intralesional cytokine expression revealed abundant production of interleukin-2, which was not dominant in granulomas from leprosy patients and was not reflected by the cytokine profile in peripheral blood mononuclear cells. These results demonstrate the capacity of the granulomatous response to recruit T cells in high numbers with only few clones expanding specifically. The high local production of interleukin-2 might thereby play an important role in the nonspecific attraction of T cells to the granulomatous site. (+info)Is granuloma annulare related to intermediate uveitis with retinal vasculitis? (7/34)
AIM: To report on eight patients with severe idiopathic intermediate uveitis (IU) and granuloma annulare (GA), a self limiting cutaneous condition of unknown aetiology. METHODS: Retrospective case series. Clinical ophthalmic and dermatological data were studied and fluorescein angiography and skin biopsies were reviewed. RESULTS: All patients with idiopathic IU had similar ocular features (eight with vitritis, seven with retinal vasculitis) and developed complications such as cystoid macular oedema (n=5), cataract (n=4), and glaucoma (n=3). Systemic diseases were not found, but a localised type of GA was observed in all. CONCLUSION: Seven out of eight patients with IU and GA developed severe retinal vasculitis. Further studies are needed for a better understanding of this association, a common pathogenesis, and its eventual clinical consequences. (+info)Granuloma annulare of the penis. (8/34)
Granuloma annulare is an uncommon skin condition, most often found on the extremities of young females. A case of granuloma annulare occurring on the penis of a 61 year old man is reported and the current literature associating granuloma annulare and conditions likely to present to genitourinary clinics is reviewed. (+info)Granuloma annulare is a chronic, inflammatory skin condition characterized by the formation of small, red or flesh-colored bumps that form rings or arcs. These lesions are usually found on the hands and feet but can occur anywhere on the body. The exact cause of granuloma annulare is unknown, but it may be associated with triggers such as insect bites, viral infections, sun exposure, or certain medications.
Histologically, granuloma annulare is characterized by a specific type of inflammatory cell infiltrate, consisting of histiocytes (a type of white blood cell) arranged in palisades around the edges of small collections of mucin (a glycoprotein). This distinctive pattern helps to differentiate granuloma annulare from other skin conditions.
Granuloma annulare is generally a benign condition that does not cause any symptoms or complications, although some people may experience itching or discomfort in the affected areas. In most cases, the lesions will resolve on their own within a few months to two years, although they can recur in some individuals. Treatment options for granuloma annulare include topical corticosteroids, phototherapy, and intralesional steroid injections, although observation is also a reasonable approach in many cases.
Dermatologic agents are medications, chemicals, or other substances that are applied to the skin (dermis) for therapeutic or cosmetic purposes. They can be used to treat various skin conditions such as acne, eczema, psoriasis, fungal infections, and wounds. Dermatologic agents include topical corticosteroids, antibiotics, antifungals, retinoids, benzoyl peroxide, salicylic acid, and many others. They can come in various forms such as creams, ointments, gels, lotions, solutions, and patches. It is important to follow the instructions for use carefully to ensure safety and effectiveness.
Necrobiosis lipoidica is a rare skin condition characterized by the formation of well-circumscribed, yellowish or brownish, slightly depressed plaques with a rolled border, often occurring on the shins. The lesions may be asymptomatic or tender and can ulcerate.
Histologically, it is marked by granulomatous inflammation with degeneration of collagen in the dermis (necrobiosis) and an accumulation of lipid-laden macrophages (lipoidosis). The exact cause of necrobiosis lipoidica is unknown, but it is often associated with diabetes mellitus. It primarily affects middle-aged women and can precede the diagnosis of diabetes. Treatment options include corticosteroids, immunomodulatory agents, and phototherapy, but the condition can be resistant to treatment and may require long-term management.
A granuloma is a small, nodular inflammatory lesion that occurs in various tissues in response to chronic infection, foreign body reaction, or autoimmune conditions. Histologically, it is characterized by the presence of epithelioid macrophages, which are specialized immune cells with enlarged nuclei and abundant cytoplasm, often arranged in a palisading pattern around a central area containing necrotic debris, microorganisms, or foreign material.
Granulomas can be found in various medical conditions such as tuberculosis, sarcoidosis, fungal infections, and certain autoimmune disorders like Crohn's disease. The formation of granulomas is a complex process involving both innate and adaptive immune responses, which aim to contain and eliminate the offending agent while minimizing tissue damage.
Penile diseases refer to a range of medical conditions that affect the penis, including infections, inflammatory conditions, and structural abnormalities. Some common penile diseases include:
1. Balanitis: an infection or inflammation of the foreskin and/or head of the penis.
2. Balanoposthitis: an infection or inflammation of both the foreskin and the head of the penis.
3. Phimosis: a condition in which the foreskin is too tight to be pulled back over the head of the penis.
4. Paraphimosis: a medical emergency in which the foreskin becomes trapped behind the head of the penis and cannot be returned to its normal position.
5. Peyronie's disease: a condition characterized by the development of scar tissue inside the penis, leading to curvature during erections.
6. Erectile dysfunction: the inability to achieve or maintain an erection sufficient for sexual intercourse.
7. Penile cancer: a rare form of cancer that affects the skin and tissues of the penis.
These conditions can have various causes, including bacterial or fungal infections, sexually transmitted infections (STIs), skin conditions, trauma, or underlying medical conditions. Treatment for penile diseases varies depending on the specific condition and its severity, but may include medications, surgery, or lifestyle changes.
Subcutaneous tissue, also known as the subcutis or hypodermis, is the layer of fatty connective tissue found beneath the dermis (the inner layer of the skin) and above the muscle fascia. It is composed mainly of adipose tissue, which serves as a energy storage reservoir and provides insulation and cushioning to the body. The subcutaneous tissue also contains blood vessels, nerves, and immune cells that support the skin's functions. This layer varies in thickness depending on the location in the body and can differ significantly between individuals based on factors such as age, genetics, and weight.
Histiocytes are a type of immune cell that are part of the mononuclear phagocyte system. They originate from monocytes, which are derived from hematopoietic stem cells in the bone marrow. Histiocytes play an important role in the immune system by engulfing and destroying foreign substances, such as bacteria and viruses, as well as removing dead cells and other debris from the body. They can be found in various tissues throughout the body, including the skin, lymph nodes, spleen, and liver.
Histiocytes include several different types of cells, such as macrophages, dendritic cells, and Langerhans cells. These cells have different functions but all play a role in the immune response. For example, macrophages are involved in inflammation and tissue repair, while dendritic cells are important for presenting antigens to T cells and initiating an immune response.
Abnormal accumulations or dysfunction of histiocytes can lead to various diseases, such as histiocytosis, which is a group of disorders characterized by the abnormal proliferation and accumulation of histiocytes in various tissues.
The scalp is the anatomical region located at the upper part of the human head, covering the skull except for the face and the ears. It is made up of several layers: the skin, the connective tissue, the galea aponeurotica (a strong, flat, tendinous sheet), loose areolar tissue, and the periosteum (the highly vascularized innermost layer that attaches directly to the skull bones). The scalp has a rich blood supply and is home to numerous sensory receptors, including those for touch, pain, and temperature. It also contains hair follicles, sebaceous glands, and sweat glands.
Fumarates are the salts or esters of fumaric acid, a naturally occurring organic compound with the formula HO2C-CH=CH-CO2H. In the context of medical therapy, fumarates are used as medications for the treatment of psoriasis and multiple sclerosis.
One such medication is dimethyl fumarate (DMF), which is a stable salt of fumaric acid. DMF has anti-inflammatory and immunomodulatory properties, and it's used to treat relapsing forms of multiple sclerosis (MS) and moderate-to-severe plaque psoriasis.
The exact mechanism of action of fumarates in these conditions is not fully understood, but they are thought to modulate the immune system and have antioxidant effects. Common side effects of fumarate therapy include gastrointestinal symptoms such as diarrhea, nausea, and abdominal pain, as well as flushing and skin reactions.
Granuloma annulare
Perforating granuloma annulare
Localized granuloma annulare
Subcutaneous granuloma annulare
Generalized granuloma annulare
Patch-type granuloma annulare
Granuloma annulare in HIV disease
Annular elastolytic giant-cell granuloma
Rheumatoid nodule
Granuloma multiforme
Dapsone
Necrobiosis
Necrobiosis lipoidica
Walter Freudenthal
Methylprednisolone
Sarcoidosis
Henry Radcliffe Crocker
Granuloma
List of MeSH codes (C23)
List of MeSH codes (C17)
Desonide
List of diseases (G)
List of skin conditions
Histopathologic diagnosis of dermatitis
Granuloma annulare - Wikipedia
Granuloma annulare: MedlinePlus Medical Encyclopedia
Granuloma Annulare: Background, Pathophysiology, Etiology
Granuloma Annulare | Johns Hopkins Medicine
granuloma annulare | West Indian Medical Journal
Granuloma annulare - NEL - Norsk Elektronisk Legehåndbok
Granuloma Annulare - Skin Disorders - MSD Manual Consumer Version
Granuloma Annulare - Kirksville Dermatologist - Cleaver Dermatology
Granuloma Annulare: Symptoms, Causes, and Treatment Options
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Annular Lesions: Diagnosis and Treatment | AAFP
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Generalized perforating granuloma annulare with varioliform scars: A case report
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Vista de Granuloma annulare and mesenchymal cancer. Report of two cases
View of Necrobiosis lipoidica and granuloma annulare: Part 2- Granuloma annulare | British Journal of Diabetes
halobetasol propionate topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Pruney fingers: Causes, conditions, and treatment
BIP! Finder - Florid Granuloma Annulare-Like Reaction in Regional Lymph Nodes After 'Regression' of Red Pigment in Tattoos.
Leg Rash | AAFP
These highlights do not include all the information needed to use ENABLEX safely and effectively. See full prescribing...
William Damsky, MD, PhD | Yale School of Medicine
guidelines - Annals Singapore
Issue November 2000 | Annals Singapore
Lesions10
- Most lesions of granuloma annulare disappear in pre-pubertal patients with no treatment within two years while older patients (50+) have rings for upwards of 20 years. (wikipedia.org)
- Localized granuloma annulare lesions usually start on the dorsal aspect of the hands and arms but may also start on the feet. (medscape.com)
- Granuloma annulare lesions develop slowly and remain for months or years. (medscape.com)
- Localized granuloma annulare is characterized by skin-colored to violaceous lesions up to 5 cm in diameter. (medscape.com)
- Subcutaneous granuloma annulare is characterized by firm or hard asymptomatic nodules in the deep dermis or subcutaneous tissues, with individual lesions measuring from 5 mm to 4 cm in diameter. (medscape.com)
- Kakourou T, Psychou F, Voutetakis A, Xaidara A, Stefanaki K, Dacou-Voutetakis C. Low serum insulin values in children with multiple lesions of granuloma annulare: a prospective study. (medscape.com)
- Annular elastolytic giant cell granuloma (AEGCG) is a controversial entity that is considered by many to be a variant of granuloma annulare (GA). The majority of cases of AEGCG occur in Caucasian women (3:2) between the ages of 40 and 70, with the distribution of the mostly annular lesions favoring exposed areas of skin and rarely involving covered skin. (elsevierpure.com)
- Granuloma annulare is a harmless type of skin rash that often presents with ring-shaped lesions. (centraldermcenter.com)
- Herbal Remedies for Granuloma Annulare can assist to decrease itching and the occurrence of the skin lesions. (phobics-awareness.org)
- Local (intra-articular or intralesional) injection of [HA734 trade name] may be given as part of the short-term management of inflammatory joint and tendon disorders, and localised inflammatory and hypertrophic skin lesions including those of lichen simplex, lichen planus, granuloma annulare, discoid lupus erythematosus, and keloids. (who.int)
Cutaneous4
- Granuloma annulare (GA) is a benign self-limited granulomatous cutaneous disorder of unknown etiology. (ijdd.in)
- Granuloma annulare (GA) and necrobiosis lipoidica (NL) are generally considered to be idiopathic cutaneous palisading granulomatous dermatitides. (thedoctorsdoctor.com)
- 10] It is characterized by noninfectious cutaneous granulomas, with underlying visceral granulomas of the lungs, liver, spleen, or conjunctiva in most patients. (medscape.com)
- Nonsarcoidal, nontuberculoid, asymptomatic cutaneous granulomas seen in CVID show well-demarcated areas of fibrinoid degeneration of collagen that stain homogeneously and are surrounded by histiocytes in a palisading arrangement (suggestive of granuloma annulare). (medscape.com)
Treat granuloma annulare2
- How do doctors treat granuloma annulare? (msdmanuals.com)
- How can you treat granuloma annulare? (dermatlanta.com)
Causes granuloma annulare2
- What causes granuloma annulare? (msdmanuals.com)
- Doctors don't know what causes granuloma annulare. (msdmanuals.com)
Subcutaneous granuloma annulare4
- Subcutaneous granuloma annulare: a review of 47 cases. (medscape.com)
- De Maeseneer M, Vande Walle H, Lenchik L, Machiels F, Desprechins B. Subcutaneous granuloma annulare: MR imaging findings. (medscape.com)
- Magnetic resonance imaging features of subcutaneous granuloma annulare. (medscape.com)
- 9. Usefulness of ultrasonography in the diagnosis of subcutaneous granuloma annulare. (nih.gov)
Lichen3
- Fontecilla NM, Kittler NW, Lopez A, Yang C, Geskin L. Programmed cell death protein-1 inhibitor-induced granuloma annulare and hypertrophic lichen planus masquerading as squamous cell carcinoma. (medscape.com)
- There are many types of rashes, including those caused by skin conditions like eczema, granuloma annulare , lichen planus , and pityriasis rosea . (webmd.com)
- Some common skin rash types include those caused by skin conditions like eczema, granuloma annulare, lichen planus, and pityriasis rosea. (webmd.com)
Pathogenesis3
- Piette EW, Rosenbach M. Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. (medscape.com)
- 6 The pathogenesis of granuloma annulare is not known although recent studies implicate activation of the T helper type 1 (Th1) cell and Janus kinase-signal transducer and activators of transcription (JAK-STAT) pathways. (clinicaladvisor.com)
- 2. Joshi TP, Duvic M. Granuloma annulare: an updated review of epidemiology, pathogenesis, and treatment options . (clinicaladvisor.com)
Granulomatous3
- Stem cell transplantation may be necessary for chronic granulomatous disease caused by granulomas. (dermatologyassociatesofmorris.com)
- Granuloma annulare is a self-limited, granulomatous inflammatory disease that is asymptomatic but often proves of cosmetic concern. (clinicaladvisor.com)
- Some authors refer to it as Palisaded Granulomatous Dermatoses to encompass the many variants which include localized (most common), generalized, patch-type or macular, subcutaneous and perforating granuloma annulare. (acadderm.com)
Inflammation3
- It can be treated with topical steroids (a medicine that reduces inflammation), but this medication does not cure granuloma annulare. (herbal-care-products.com)
- If you have granuloma annulare, you can use topically applied steroids to reduce inflammation and make the skin less red. (herbal-care-products.com)
- Granuloma annulare is inflammation in the deep layer of the skin (dermis). (azurewebsites.net)
Perforating1
- Perforating granuloma annulare is usually localized to the dorsal hands and fingers or may be generalized on the trunk and extremities. (medscape.com)
Diagnosis2
- After the diagnosis is confirmed, granuloma annulare can be treated with topical medications, corticosteroid injections, cryotherapy (freezing the bumps), light-based or laser skin treatments , and in rare cases of widespread rashes, oral medications. (dermatlanta.com)
- Plus, skin conditions that may be more serious and contagious can be mistaken for granuloma annulare, so whether you plan to treat it or not, it's important to get an accurate diagnosis. (dermatlanta.com)
Erythema2
- Arcuate dermal erythema: This is an uncommon form of granuloma annulare that manifests as infiltrated erythematous patches that may form large, hyperpigmented rings with central clearing. (medscape.com)
- In acute presentation in can be confused with secondary syphilis, granuloma annulare and erythema annulare centrifugum. (globale-dermatologie.com)
Etiology1
- The etiology of granuloma annulare is usually unknown, and the pathogenetic mechanisms are poorly understood, with a vast majority of granuloma annulare cases occurring in patients who are otherwise healthy. (medscape.com)
Diabetes Mellitus2
- When granuloma annulare is widespread, it may be associated with underlying diabetes mellitus. (healthhub.sg)
- Patients with widespread granuloma annulare need to be screened for diabetes mellitus. (healthhub.sg)
Rash4
- Aside from the visible rash, granuloma annulare is usually asymptomatic. (wikipedia.org)
- Granuloma annulare (GA) is a long-term ( chronic ) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. (medlineplus.gov)
- Granuloma annulare is a harmless type of skin rash. (lluh.org)
- Granuloma annulare , or GA, is often a distinctive rash diagnosable on sight. (dermatlanta.com)
Necrobiosis lipoidica2
- Harth W, Linse R. Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. (medscape.com)
- Granuloma annulare and necrobiosis lipoidica tissue reactions as a manifestation of systemic disease. (thedoctorsdoctor.com)
Treatments3
- The most common treatments for granuloma annulare are topical and/or intralesional steroids, and there has been some success with PUVA treatments. (medscape.com)
- Treatments for granuloma annulare can include steroid medicines, freezing the affected area of skin and ultraviolet light therapy. (azurewebsites.net)
- Chapter 2406 Repaying medications good to lower blood sugar debts Wang diabetes granuloma annulare treatments Yue turned his head and looked at the cripple who was talking to himself with a fierce expression At this time, the cripple raised his head and looked at Wang Yue with big eyes. (scbolivia33.org)
Erythematous3
- Granuloma annulare is characterized by rings of closely set, small, smooth, firm papules which usually are skin colored but may also be slightly erythematous or have a purplish hue. (medscape.com)
- Erythematous granuloma annulare has responded dramatically to narrow-band therapy, he says. (androv-medical.ch)
- Clinically, granuloma annulare presents with multiple widespread erythematous to hyperpigmented macules or papules that may coalesce to form annular plaques. (clinicaladvisor.com)
Radcliffe Crocker2
- The disease was first described in 1895 by Thomas Colcott Fox as a "ringed eruption of the fingers", and it was named granuloma annulare by Henry Radcliffe Crocker in 1902. (wikipedia.org)
- however, not until 1902 did Radcliffe-Crocker label it as granuloma annulare. (medscape.com)
Actinic granuloma3
- Some authorities consider actinic granuloma (AG) to be a subset of granuloma annulare, but others view actinic annulare as a separate, but related, entity. (medscape.com)
- Ghadially R. Granuloma annulare, actinic granuloma. (medscape.com)
- O'Brien JP, Regan W. Actinically degenerate elastic tissue is the likely antigenic basis of actinic granuloma of the skin and of temporal arteritis. (medscape.com)
Contagious3
- Is granuloma annulare contagious? (dermatlanta.com)
- No. While researchers don't know the exact causes of granuloma annulare, they do know that it's not contagious. (dermatlanta.com)
- Granuloma annulare is not contagious and it's not cancerous. (herbal-care-products.com)
Predominantly in children1
- Granuloma annulare can occur at any age, but is seen predominantly in children and young adults. (medscape.com)
Symptoms4
- What are the symptoms of granuloma annulare? (msdmanuals.com)
- The symptoms of granuloma annulare can be like other health conditions. (lluh.org)
- It's very common for granuloma annulare to be mistaken for ringworm because their symptoms look similar. (dermatlanta.com)
- Liquid nitrogen, laser therapy, and various forms of oral medications are used to treat the symptoms of granulomas. (dermatologyassociatesofmorris.com)
Widespread1
- I certainly have cleared people who have widespread granuloma annulare, and it certainly can be considered," although "I think UVA-1 is probably better," he said. (androv-medical.ch)
Bumpy1
- Granuloma annulare is a skin disease that causes a bumpy red patch on the skin. (herbal-care-products.com)
Occur1
- However, if granulomas occur in the lungs or other internal organs, your doctor will have to perform a CT scan, x-ray, or blood test to diagnose it. (dermatologyassociatesofmorris.com)
Herbal Remedies1
- A person can use different Herbal Remedies for Granuloma Annulare to obtain relief from this problem. (phobics-awareness.org)
Thyroid disease1
- 3 Several disorders have been associated with disseminated granuloma annulare including diabetes, thyroid disease, malignancies, and HIV. (clinicaladvisor.com)
Anular2
Harmless skin2
- Granuloma annulare is a harmless skin reaction that causes small, firm, raised bumps on the skin. (msdmanuals.com)
- Fortunately, granuloma annulare is a rather harmless skin condition in the long run, but it doesn't feel that way to those who suffer from it. (dermatlanta.com)
Clinical2
- There is unfortunately a lack of clinical evidence about the effectiveness of UVB treatment for Granuloma Annulare although we do at least have some customer feedback from our anonymous (and optional! (androv-medical.ch)
- Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study. (aimilioslallas.com)
Treatment10
- Recurrent granuloma annulare during treatment with daclizumab. (medscape.com)
- Treatment of granuloma annulare with the 585 nm pulsed dye laser. (medscape.com)
- Sliger BN, Burk CJ, Alvarez-Connelly E. Treatment of granuloma annulare with the 595 nm pulsed dye laser in a pediatric patient. (medscape.com)
- Treatment of granuloma annulare with the 595-nm pulsed dye laser, a multicentre retrospective study with long-term follow-up. (medscape.com)
- Surveys are undertaken as a system to continually improve our business management and products - although in cases can also highlight the effectiveness of a treatment for rarer skin conditions such as Granuloma Annulare. (androv-medical.ch)
- Here are some best Natural home cure for Generalized Granuloma Annulare Treatment completely without any side effects. (natural-health-news.com)
- There are several different treatment options for granulomas based on their location and severity. (dermatologyassociatesofmorris.com)
- While some granulomas don't require any treatment, some may require surgeries or even lung transplants. (dermatologyassociatesofmorris.com)
- The aims of using Herbal Treatment for Granuloma Annulare internal factors by addressing the immune system using the herbal supplement. (phobics-awareness.org)
- Herbal Treatment for Granuloma Annulare can help me manages this condition. (phobics-awareness.org)
Idiopathic2
- Granuloma annulare is an idiopathic condition, though many catalysts have been proposed. (wikipedia.org)
- Granuloma Annulare (GA) is a common idiopathic disorder of the dermis and subcutaneous tissues. (acadderm.com)
Immune4
- Proposed pathogenic mechanisms for granuloma annulare include cell-mediated immunity (type IV), immune complex vasculitis, and an abnormality of tissue monocytes. (medscape.com)
- Granuloma annulare associated with immune checkpoint inhibitors. (medscape.com)
- A granuloma is a cluster of immune cells which generally function to wall off an infection or foreign object. (dermatlanta.com)
- Understanding the cause of Granuloma Annulare as auto-immune, suggesting internal, immunological factors responsible for the disease. (phobics-awareness.org)
Sarcoidosis2
- These are pulmonary granulomas and can cause a serious condition known as pulmonary sarcoidosis. (dermatologyassociatesofmorris.com)
- A lung transplant is the only way to repair your condition in the most extreme cases where granulomas cause severe pulmonary sarcoidosis. (dermatologyassociatesofmorris.com)
Benign1
- Granuloma annulare (GA) is a benign inflammatory dermatosis. (medscape.com)
Cancerous1
- Granulomas often get mistaken for cancerous growths because of how they appear, but they are, in fact, natural defenders that your body creates. (dermatologyassociatesofmorris.com)
Dermal1
- citation needed] Granuloma annulare microscopically consists of dermal epithelioid histiocytes around a central zone of mucin-a so-called palisaded granuloma. (wikipedia.org)
Patients3
- Successful outcome of cryosurgery in patients with granuloma annulare. (medscape.com)
- To work toward this goal, today we're answering some common questions patients ask about a lesser-known skin condition: granuloma annulare. (dermatlanta.com)
- While it doesn't carry a risk for your health, granuloma can bring plenty of emotional discomfort to patients. (dermatlanta.com)
Chronic skin condition2
- Granuloma annulare (GA) is a common, sometimes chronic skin condition which presents as reddish bumps on the skin arranged in a circle or ring. (wikipedia.org)
- Granuloma annulare is a chronic skin condition. (webmd.com)
Infection2
- Granuloma annulare triggered by SARS-CoV-2 infection. (nih.gov)
- If the initial swarm of macrophages isn't enough to stop the spread of infection, more granulomas form and flee to the scene. (dermatologyassociatesofmorris.com)
Mistaken1
- Granulomas are one of your body's many defense mechanisms and often get mistaken for foreign invaders because of how they manifest and operate. (dermatologyassociatesofmorris.com)
Fingers1
- The most common symptom of granuloma annulare is a circle of small pink, purple or skin-coloured bumps on the hands, fingers, elbows or feet. (azurewebsites.net)
Remedies1
- To treat a skin condition, Natural Remedies for Granuloma Annulare can be applied on regular basis to get a positive outcome. (vevioz.com)
Cite1
- Cite this: Granuloma Annulare - Medscape - Dec 01, 2004. (medscape.com)
Lungs2
- A granuloma is a cluster of white blood cells that typically form in the lungs as a defense mechanism, but they can also form on the head, skin, or several other body parts. (dermatologyassociatesofmorris.com)
- It's important to diagnose internal granulomas soon after their formation, especially granulomas in the lungs. (dermatologyassociatesofmorris.com)
Skin condition1
- Granuloma annulare is a skin condition that often looks like a ring of bumps. (azurewebsites.net)
Common2
- Granuloma annulare is relatively common disease that occurs in all age groups, but it is rare in infancy. (medscape.com)
- Localized granuloma annulare: This is the most common form. (medscape.com)
Researchers1
- Researchers don't know how to prevent granuloma annulare. (lluh.org)
Successfully1
- Granuloma annulare successfully treated using fractional photothermolysis with a 1,550-nm erbium-doped yttrium aluminum garnet fractionated laser. (medscape.com)
Creams2
- Some people choose to treat their granuloma annulare themselves by applying creams or sprays containing these drugs directly onto their skin. (herbal-care-products.com)
- Corticosteroids are often used to treat skin granulomas and come in the form of injections, creams, or pills. (dermatologyassociatesofmorris.com)
Diseases1
- The range of predisposing events and associated diseases is diverse, and granuloma annulare is thought to represent a reaction pattern with many different initiating factors. (medscape.com)
Condition1
- Drinking alcohol can lead to Granuloma Annulare worsening or getting worse because it increases your risk of developing this condition in the first place and could also make it worse if you already have it. (herbal-care-products.com)