A mild, highly infectious viral disease of children, characterized by vesicular lesions in the mouth and on the hands and feet. It is caused by coxsackieviruses A.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot occurring at or before birth.
Alterations or deviations from normal shape or size which result in a disfigurement of the hand occurring at or before birth.
A species of ENTEROVIRUS infecting humans and containing 10 serotypes, mostly coxsackieviruses.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Foot-and-Mouth Disease (FMD) is a highly contagious and severe viral disease in cloven-hoofed animals, characterized by fever, formation of vesicles and erosions in the mouth, on the tongue, lips, teats, and feet, causing significant economic losses in agriculture and livestock farming.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
Enterovirus Infections are acute viral illnesses caused by various Enterovirus serotypes, primarily transmitted through the fecal-oral route, manifesting as a wide range of clinical symptoms, from asymptomatic or mild self-limiting fever to severe and potentially life-threatening conditions, such as meningitis, encephalitis, myocarditis, and neonatal sepsis-like illness, depending on the age, immune status, and serotype of the infected individual.
Herpangina is a mild, self-limiting viral infection predominantly affecting children during summer and fall, characterized by the sudden onset of fever, sore throat, and small vesicles or ulcers on the posterior palate and tonsillar pillars.
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.
A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.
Anatomical and functional disorders affecting the foot.
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A plant genus of the family POACEAE. Finger millet or raggee (E. coracana) is an important food grain in southern Asia and parts of Africa.
Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.
A country spanning from central Asia to the Pacific Ocean.
Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.
Proteins that form the CAPSID of VIRUSES.
Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.
General or unspecified injuries involving the foot.
Domesticated farm animals raised for home use or profit but excluding POULTRY. Typically livestock includes CATTLE; SHEEP; HORSES; SWINE; GOATS; and others.
A neurological condition that is characterized by uncontrolled rapid irregular movements of the eye (OPSOCLONUS) and the muscle (MYOCLONUS) causing unsteady, trembling gait. It is also known as dancing eyes-dancing feet syndrome and is often associated with neoplasms, viral infections, or autoimmune disorders involving the nervous system.
Alterations or deviations from normal shape or size which result in a disfigurement of the foot.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
The relationships of groups of organisms as reflected by their genetic makeup.
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
A syndrome characterized by headache, neck stiffness, low grade fever, and CSF lymphocytic pleocytosis in the absence of an acute bacterial pathogen. Viral meningitis is the most frequent cause although MYCOPLASMA INFECTIONS; RICKETTSIA INFECTIONS; diagnostic or therapeutic procedures; NEOPLASTIC PROCESSES; septic perimeningeal foci; and other conditions may result in this syndrome. (From Adams et al., Principles of Neurology, 6th ed, p745)
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
'Mouth diseases' is a broad term referring to various conditions that cause inflammation, infection, or structural changes in any part of the mouth, including the lips, gums, tongue, palate, cheeks, and teeth, which can lead to symptoms such as pain, discomfort, difficulty in chewing or speaking, and altered aesthetics.
The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
I'm sorry for any confusion, but "Singapore" is not a medical term or concept, it's a country in Southeast Asia. If you have any questions about medical topics, I'd be happy to try and help!
Ribonucleic acid that makes up the genetic material of viruses.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The "mouth floor" refers to the inferior aspect of the oral cavity, which is formed by the muscular floor of the mouth, consisting primarily of the mylohyoid muscle, and contains the opening of the sublingual and submandibular glands.

Sentinel surveillance for enterovirus 71, Taiwan, 1998. (1/171)

Outbreaks of enterovirus 71 have been reported around the world since 1969. The most recent outbreak occurred in Taiwan during April-July 1998. This hand, foot, and mouth disease epidemic was detected by a sentinel surveillance system in April at the beginning of the outbreak, and the public was alerted.  (+info)

An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. (2/171)

BACKGROUND: Enteroviruses can cause outbreaks of hand-foot-and-mouth disease (characterized by vesicular lesions on the hands, feet, and oral mucosa) or herpangina, usually without life-threatening manifestations. In 1998 an epidemic of enterovirus 71 infection caused hand-foot-and-mouth disease and herpangina in thousands of people in Taiwan, some of whom died. METHODS: We assessed the epidemiologic aspects of this outbreak. Cases of hand-foot-and-mouth disease or herpangina in ambulatory patients were reported to the Taiwan Department of Health by a mean of 818 sentinel physicians. Severe cases in hospitalized patients were reported by 40 medical centers and regional hospitals. Viruses were isolated by 10 hospital laboratories and the department of health. RESULTS: The sentinel physicians reported 129,106 cases of hand-foot-and-mouth disease or herpangina in two waves of the epidemic, which probably represents less than 10 percent of the estimated total number of cases. There were 405 patients with severe disease, most of whom were five years old or younger; severe disease was seen in all regions of the island. Complications included encephalitis, aseptic meningitis, pulmonary edema or hemorrhage, acute flaccid paralysis, and myocarditis. Seventy-eight patients died, 71 of whom (91 percent) were five years of age or younger. Of the patients who died, 65 (83 percent) had pulmonary edema or pulmonary hemorrhage. Among patients from whom a virus was isolated, enterovirus 71 was present in 48.7 percent of outpatients with uncomplicated hand-foot-and-mouth disease or herpangina, 75 percent of hospitalized patients who survived, and 92 percent of patients who died. CONCLUSIONS: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths. Most of those who died were young, and the majority died of pulmonary edema and pulmonary hemorrhage.  (+info)

Neurologic complications in children with enterovirus 71 infection. (3/171)

BACKGROUND: Enterovirus 71 infection causes hand-foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting, ulcerative lesions in the oral mucosa, and vesicles on the backs of the hands and feet. The initial illness resolves but is sometimes followed by aseptic meningitis, encephalomyelitis, or even acute flaccid paralysis similar to paralytic poliomyelitis. METHODS: We describe the neurologic complications associated with the enterovirus 71 epidemic that occurred in Taiwan in 1998. At three major hospitals we identified 41 children with culture-confirmed enterovirus 71 infection and acute neurologic manifestations. Magnetic resonance imaging (MRI) was performed in 4 patients with acute flaccid paralysis and 24 with rhombencephalitis. RESULTS: The mean age of the patients was 2.5 years (range, 3 months to 8.2 years). Twenty-eight patients had hand-foot-and-mouth disease (68 percent), and 6 had herpangina (15 percent). The other seven patients had no skin or mucosal lesions. Three neurologic syndromes were identified: aseptic meningitis (in 3 patients); brain-stem encephalitis, or rhombencephalitis (in 37); and acute flaccid paralysis (in 4), which followed rhombencephalitis in 3 patients. In 20 patients with rhombencephalitis, the syndrome was characterized by myoclonic jerks and tremor, ataxia, or both (grade I disease). Ten patients had myoclonus and cranial-nerve involvement (grade II disease). In seven patients the brain-stem infection produced transient myoclonus followed by the rapid onset of respiratory distress, cyanosis, poor peripheral perfusion, shock, coma, loss of the doll's eye reflex, and apnea (grade III disease); five of these patients died within 12 hours after admission. In 17 of the 24 patients with rhombencephalitis who underwent MRI, T2-weighted scans showed high-intensity lesions in the brain stem, most commonly in the pontine tegmentum. At follow-up, two of the patients with acute flaccid paralysis had residual limb weakness, and five of the patients with rhombencephalitis had persistent neurologic deficits, including myoclonus (in one child), cranial-nerve deficits (in two), and ventilator-dependent apnea (in two). CONCLUSIONS: In the 1998 enterovirus 71 epidemic in Taiwan, the chief neurologic complication was rhombencephalitis, which had a fatality rate of 14 percent. The most common initial symptoms were myoclonic jerks, and MRI usually showed evidence of brainstem involvement.  (+info)

Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. (4/171)

Enterovirus 71 (EV71) (genus Enterovirus, family Picornaviridae), a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. To examine the genetic diversity and rate of evolution of EV71, we have determined and analyzed complete VP1 sequences (891 nucleotides) for 113 EV71 strains isolated in the United States and five other countries from 1970 to 1998. Nucleotide sequence comparisons demonstrated three distinct EV71 genotypes, designated A, B, and C. The genetic variation within genotypes (12% or fewer nucleotide differences) was less than the variation between genotypes (16.5 to 19.7%). Strains of all three genotypes were at least 94% identical to one another in deduced amino acid sequence. The EV71 prototype strain, BrCr-CA-70, isolated in California in 1970, is the sole member of genotype A. Strains isolated in the United States and Australia during the period from 1972 to 1988, a 1994 Colombian isolate, and isolates from a large HFMD outbreak in Malaysia in 1997 are all members of genotype B. Although strains of genotype B continue to circulate in other parts of the world, none have been isolated in the United States since 1988. Genotype C contains strains isolated in 1985 or later in the United States, Canada, Australia, and the Republic of China. The annual rate of evolution within both the B and C genotypes was estimated to be approximately 1.35 x 10(-2) substitutions per nucleotide and is similar to the rate observed for poliovirus. The results indicate that EV71 is a genetically diverse, rapidly evolving virus. Its worldwide circulation and potential to cause severe disease underscore the need for additional surveillance and improved methods to identify EV71 in human disease.  (+info)

MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan. (5/171)

BACKGROUND AND PURPOSE: An outbreak of enterovirus infection occurred in Taiwan from late spring to early fall of 1998. Most of the pediatric infections presented as hand-foot-mouth disease (HFMD) and herpangina. A small portion of patients had symptoms of polio-like encephalitis and paralysis. The purpose of this study was to review the MR imaging findings in CNS involvement of enterovirus infection. METHODS: Twenty patients who had HFMD and clinical encephalitis were examined with MR imaging. T1-weighted and T2-weighted MR images were obtained. From the rectum, throat, CSF, and peripheral blood, the presence of enterovirus 71 (EV 71) was determined by virus culture, immunofluorescent microscopy, immunologic dot blotting, and reverse-transcription polymerase chain reaction. RESULTS: MR imaging studies of 20 patients showed hyperintensity in the brain stem and spinal cord in 15 patients, as seen on T2-weighted images. The major CNS lesions were in the medulla oblongata, pons, midbrain, and the dentate nuclei of the cerebellum. In some cases, the lesions involved the spinal cord (three cases) as well as the thalamus (two cases) and putamina (one case). Five patients had normal MR imaging results. After the appropriate management for tachycardia and tachypnea, 18 patients recovered within 1 to 2 weeks. In the follow-up MR imaging examination of five patients, the lesions completely disappeared within 2 weeks to 2 months. In two patients who were still respirator-dependent, MR imaging showed the tissue destruction in the posterior portions of the medulla, pons, and the ventral horns of cervical spinal cord. In one patient, most of midbrain was damaged. The presence of EV 71 was detected in specimens from 18 patients. CONCLUSION: Because EV 71 was identified in 18 patients, and no other virus was detected, EV 71 was determined to be the major causative agent of this encephalomyelitis. Brain stem and cervical spinal cord involvement are characteristic findings of enteroviral encephalomyelitis.  (+info)

Guillain-Barre syndrome following hand-foot-and-mouth disease. (6/171)

We describe a patient who developed Guillain-Barre syndrome (GBS) following hand-foot-and-mouth disease (HFMD) which is known to be caused by enterovirus infection. A 35-year-old man developed acute paraparesis and dysesthesia in the four limbs following typical skin eruption of HFMD. Electrophysiologic studies showed peripheral nerve demyelination predominant in the distal terminals. HFMD is a rare cause of meningitis, encephalitis, and polio-like myelitis, but GBS following HFMD has never been described.  (+info)

Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. (7/171)

From April through June 1997, 29 previously healthy children aged <6 years (median, 1.5 years) in Sarawak, Malaysia, died of rapidly progressive cardiorespiratory failure during an outbreak of hand, foot, and mouth disease caused primarily by enterovirus 71 (EV71). The case children were hospitalized after a short illness (median duration, 2 days) that usually included fever (in 100% of case children), oral ulcers (66%), and extremity rashes (62%). The illness rapidly progressed to include seizures (28%), flaccid limb weakness (17%), or cardiopulmonary symptoms (of 24 children, 17 had chest radiographs showing pulmonary edema, and 24 had echocardiograms showing left ventricular dysfunction), resulting in cardiopulmonary arrest soon after hospitalization (median time, 9 h). Cardiac tissue from 10 patients showed normal myocardium, but central nervous system tissue from 5 patients showed inflammatory changes. Brain-stem specimens from 2 patients were available, and both specimens showed extensive neuronal degeneration, inflammation, and necrosis, suggesting that a central nervous system infection was responsible for the disease, with the cardiopulmonary dysfunction being neurogenic in origin. EV71 and possibly an adenovirus, other enteroviruses, or unknown cofactors are likely responsible for this rapidly fatal disease.  (+info)

Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan: report of an autopsy case with pathologic, immunofluorescence, and molecular studies. (8/171)

We report a fatal case of enterovirus type 71 (EV 71) infection in an 8-year-old girl during a summer outbreak of hand, foot, and mouth disease in 1998 in Taiwan. The clinical course was rapidly progressive, with manifestations of hand, foot, and mouth disease, aseptic meningitis, encephalomyelitis, and pulmonary edema. The patient died 24 hours after admission. Postmortem study revealed extensive inflammation in the meninges and central nervous system and marked pulmonary edema with focal hemorrhage. Brain stem and spinal cord were most severely involved. The inflammatory infiltrates consisted largely of neutrophils involving primarily the gray matter with perivascular lymphocytic cuffing, and neuronophagia. The lungs and heart showed no evidence of inflammation. EV 71 was isolated from the fresh brain tissues and identified by immunofluorescence method with type-specific EV 71 monoclonal antibody. It was also confirmed by neutralization test and reverse-transcriptase polymerase chain reaction with sequence analysis. The present case was the first example in which EV 71 was demonstrated to be the causative agent of fatal encephalomyelitis during its epidemic in Taiwan.  (+info)

Hand, foot, and mouth disease (HFMD) is a mild, contagious viral infection common in infants and children but can sometimes occur in adults. The disease is often caused by coxsackievirus A16 or enterovirus 71.

The name "hand, foot and mouth" comes from the fact that blister-like sores usually appear in the mouth (and occasionally on the buttocks and legs) along with a rash on the hands and feet. The disease is not related to foot-and-mouth disease (also called hoof-and-mouth disease), which affects cattle, sheep, and swine.

HFMD is spread through close personal contact, such as hugging and kissing, or through the air when an infected person coughs or sneezes. It can also be spread by touching objects and surfaces that have the virus on them and then touching the face. People with HFMD are most contagious during the first week of their illness but can still be contagious for weeks after symptoms go away.

There is no specific treatment for HFMD, and it usually resolves on its own within 7-10 days. However, over-the-counter pain relievers and fever reducers may help alleviate symptoms. It's important to encourage good hygiene practices, such as handwashing and covering the mouth and nose when coughing or sneezing, to prevent the spread of HFMD.

Congenital foot deformities refer to abnormal structural changes in the foot that are present at birth. These deformities can vary from mild to severe and may affect the shape, position, or function of one or both feet. Common examples include clubfoot (talipes equinovarus), congenital vertical talus, and cavus foot. Congenital foot deformities can be caused by genetic factors, environmental influences during fetal development, or a combination of both. Treatment options may include stretching, casting, surgery, or a combination of these approaches, depending on the severity and type of the deformity.

Congenital hand deformities refer to physical abnormalities or malformations of the hand, wrist, and/or digits (fingers) that are present at birth. These deformities can result from genetic factors, environmental influences during pregnancy, or a combination of both. They may affect the bones, muscles, tendons, joints, and other structures in the hand, leading to varying degrees of impairment in function and appearance.

There are numerous types of congenital hand deformities, some of which include:

1. Polydactyly: The presence of extra digits on the hand, which can be fully formed or rudimentary.
2. Syndactyly: Webbing or fusion of two or more fingers, which may involve soft tissue only or bone as well.
3. Clinodactyly: A curved finger due to a sideways deviation of the fingertip, often affecting the little finger.
4. Camptodactyly: Permanent flexion or bending of one or more fingers, typically involving the proximal interphalangeal joint.
5. Trigger Finger/Thumb: A condition where a finger or thumb becomes locked in a bent position due to thickening and narrowing of the tendon sheath.
6. Radial Club Hand (Radial Ray Deficiency): Underdevelopment or absence of the radius bone, resulting in a short, curved forearm and hand deformity.
7. Ulnar Club Hand (Ulnar Ray Deficiency): Underdevelopment or absence of the ulna bone, leading to a short, curved forearm and hand deformity.
8. Cleidocranial Dysplasia: A genetic disorder affecting bone growth, resulting in underdeveloped or absent collarbones, dental abnormalities, and occasionally hand deformities.
9. Apert Syndrome: A rare genetic disorder characterized by the fusion of fingers and toes (syndactyly) and other skeletal abnormalities.
10. Holt-Oram Syndrome: A genetic disorder involving heart defects and upper limb deformities, such as radial ray deficiency or thumb anomalies.

Treatment for hand deformities varies depending on the specific condition and severity. Options may include physical therapy, bracing, splinting, medications, or surgical intervention.

Enterovirus A, Human is a type of enterovirus that infects humans. Enteroviruses are small, single-stranded RNA viruses that belong to the Picornaviridae family. There are over 100 different types of enteroviruses, and they are divided into several species, including Enterovirus A, B, C, D, and Rhinovirus.

Enterovirus A includes several important human pathogens, such as polioviruses (which have been largely eradicated thanks to vaccination efforts), coxsackieviruses, echoviruses, and enterovirus 71. These viruses are typically transmitted through the fecal-oral route or respiratory droplets and can cause a range of illnesses, from mild symptoms like fever, rash, and sore throat to more severe diseases such as meningitis, encephalitis, myocarditis, and paralysis.

Poliovirus, which is the most well-known member of Enterovirus A, was responsible for causing poliomyelitis, a highly infectious disease that can lead to irreversible paralysis. However, due to widespread vaccination programs, wild poliovirus transmission has been eliminated in many parts of the world, and only a few countries still report cases of polio caused by vaccine-derived viruses.

Coxsackieviruses and echoviruses can cause various symptoms, including fever, rash, mouth sores, muscle aches, and respiratory illnesses. In some cases, they can also lead to more severe diseases such as meningitis or myocarditis. Enterovirus 71 is a significant pathogen that can cause hand, foot, and mouth disease, which is a common childhood illness characterized by fever, sore throat, and rash on the hands, feet, and mouth. In rare cases, enterovirus 71 can also lead to severe neurological complications such as encephalitis and polio-like paralysis.

Prevention measures for enterovirus A infections include good hygiene practices, such as washing hands frequently, avoiding close contact with sick individuals, and practicing safe food handling. Vaccination is available for poliovirus and can help prevent the spread of vaccine-derived viruses. No vaccines are currently available for other enterovirus A infections, but research is ongoing to develop effective vaccines against these viruses.

Congenital limb deformities refer to abnormalities in the structure, position, or function of the arms or legs that are present at birth. These deformities can vary greatly in severity and may affect any part of the limb, including the bones, muscles, joints, and nerves.

Congenital limb deformities can be caused by genetic factors, exposure to certain medications or chemicals during pregnancy, or other environmental factors. Some common types of congenital limb deformities include:

1. Clubfoot: A condition in which the foot is twisted out of shape, making it difficult to walk normally.
2. Polydactyly: A condition in which a person is born with extra fingers or toes.
3. Radial clubhand: A rare condition in which the radius bone in the forearm is missing or underdeveloped, causing the hand to turn inward and the wrist to bend.
4. Amniotic band syndrome: A condition in which strands of the amniotic sac wrap around a developing limb, restricting its growth and leading to deformities.
5. Agenesis: A condition in which a limb or part of a limb is missing at birth.

Treatment for congenital limb deformities may include surgery, bracing, physical therapy, or other interventions depending on the severity and nature of the deformity. In some cases, early intervention and treatment can help to improve function and reduce the impact of the deformity on a person's daily life.

In medical terms, the foot is the part of the lower limb that is distal to the leg and below the ankle, extending from the tarsus to the toes. It is primarily responsible for supporting body weight and facilitating movement through push-off during walking or running. The foot is a complex structure made up of 26 bones, 33 joints, and numerous muscles, tendons, ligaments, and nerves that work together to provide stability, balance, and flexibility. It can be divided into three main parts: the hindfoot, which contains the talus and calcaneus (heel) bones; the midfoot, which includes the navicular, cuboid, and cuneiform bones; and the forefoot, which consists of the metatarsals and phalanges that form the toes.

Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals, including cattle, sheep, goats, pigs, and buffalo. The virus can also infect wild animals like deer and antelope. FMD is not a direct threat to human health but may have significant economic impacts due to restrictions on trade and movement of infected animals.

The disease is characterized by fever, blister-like sores (vesicles) in the mouth, on the tongue, lips, gums, teats, and between the hooves. The vesicles can rupture, causing painful erosions that make it difficult for affected animals to eat, drink, or walk. In severe cases, FMD can lead to death, particularly among young animals.

The causative agent of foot-and-mouth disease is the foot-and-mouth disease virus (FMDV), which belongs to the Picornaviridae family and Aphthovirus genus. There are seven serotypes of FMDV: O, A, C, Asia 1, and South African Territories (SAT) 1, SAT 2, and SAT 3. Infection with one serotype does not provide cross-protection against other serotypes.

Prevention and control measures for foot-and-mouth disease include vaccination, quarantine, movement restrictions, disinfection, and culling of infected animals in severe outbreaks. Rapid detection and response are crucial to prevent the spread of FMD within and between countries.

An enterovirus is a type of virus that primarily infects the gastrointestinal tract. There are over 100 different types of enteroviruses, including polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses such as EV-D68 and EV-A71. These viruses are typically spread through close contact with an infected person, or by consuming food or water contaminated with the virus.

While many people infected with enteroviruses may not experience any symptoms, some may develop mild to severe illnesses such as hand, foot and mouth disease, herpangina, meningitis, encephalitis, myocarditis, and paralysis (in case of poliovirus). Infection can occur in people of all ages, but young children are more susceptible to infection and severe illness.

Prevention measures include practicing good hygiene, such as washing hands frequently with soap and water, avoiding close contact with sick individuals, and not sharing food or drinks with someone who is ill. There are also vaccines available to prevent poliovirus infection.

Enterovirus infections are viral illnesses caused by enteroviruses, which are a type of picornavirus. These viruses commonly infect the gastrointestinal tract and can cause a variety of symptoms depending on the specific type of enterovirus and the age and overall health of the infected individual.

There are over 100 different types of enteroviruses, including polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses such as EV-D68 and EV-A71. Some enterovirus infections may be asymptomatic or cause only mild symptoms, while others can lead to more severe illnesses.

Common symptoms of enterovirus infections include fever, sore throat, runny nose, cough, muscle aches, and skin rashes. In some cases, enteroviruses can cause more serious complications such as meningitis (inflammation of the membranes surrounding the brain and spinal cord), encephalitis (inflammation of the brain), myocarditis (inflammation of the heart muscle), and paralysis.

Enterovirus infections are typically spread through close contact with an infected person, such as through respiratory droplets or fecal-oral transmission. They can also be spread through contaminated surfaces or objects. Preventive measures include good hygiene practices, such as washing hands frequently and avoiding close contact with sick individuals.

There are no specific antiviral treatments for enterovirus infections, and most cases resolve on their own within a few days to a week. However, severe cases may require hospitalization and supportive care, such as fluids and medication to manage symptoms. Prevention efforts include vaccination against poliovirus and surveillance for emerging enteroviruses.

Herpangina is a mild, self-limiting viral infection that primarily affects children under the age of 10. It is characterized by the sudden onset of fever, sore throat, and small vesicles or ulcers (

In medical terms, the mouth is officially referred to as the oral cavity. It is the first part of the digestive tract and includes several structures: the lips, vestibule (the space enclosed by the lips and teeth), teeth, gingiva (gums), hard and soft palate, tongue, floor of the mouth, and salivary glands. The mouth is responsible for several functions including speaking, swallowing, breathing, and eating, as it is the initial point of ingestion where food is broken down through mechanical and chemical processes, beginning the digestive process.

Aphthovirus is a genus of viruses in the family Picornaviridae, order Picornavirales. This genus includes several species of viruses that are primarily associated with causing oral and foot lesions in cloven-hoofed animals, such as cattle, sheep, and pigs. The most well-known member of this genus is foot-and-mouth disease virus (FMDV), which causes a highly contagious and economically significant disease in livestock. Other species in the Aphthovirus genus include equine rhinitis A virus, bovine rhinitis virus, and porcine teschovirus. These viruses are typically transmitted through direct contact with infected animals or their secretions and excretions, and they can cause a range of clinical signs including fever, loss of appetite, lameness, and lesions in the mouth and feet. There are currently no vaccines available for all serotypes of FMDV, and control measures typically involve quarantine, slaughter of infected animals, and strict biosecurity practices to prevent spread of the virus.

Foot-and-Mouth Disease Virus (FMDV) is a single-stranded, positive-sense RNA virus belonging to the family Picornaviridae and the genus Aphthovirus. It is the causative agent of Foot-and-Mouth Disease (FMD), a highly contagious and severe viral disease that affects cloven-hoofed animals, including cattle, swine, sheep, goats, and buffalo. The virus can be transmitted through direct contact with infected animals or their bodily fluids, as well as through aerosolized particles in the air. FMDV has seven distinct serotypes (O, A, C, Asia 1, and South African Territories [SAT] 1, 2, and 3), and infection with one serotype does not provide cross-protection against other serotypes. The virus primarily targets the animal's epithelial tissues, causing lesions and blisters in and around the mouth, feet, and mammary glands. FMD is not a direct threat to human health but poses significant economic consequences for the global livestock industry due to its high infectivity and morbidity rates.

In medical terms, a hand is the part of the human body that is attached to the forearm and consists of the carpus (wrist), metacarpus, and phalanges. It is made up of 27 bones, along with muscles, tendons, ligaments, and other soft tissues. The hand is a highly specialized organ that is capable of performing a wide range of complex movements and functions, including grasping, holding, manipulating objects, and communicating through gestures. It is also richly innervated with sensory receptors that provide information about touch, temperature, pain, and proprioception (the sense of the position and movement of body parts).

Coxsackievirus infections are a type of viral illness caused by Coxsackie A and B viruses, which belong to the family Picornaviridae. These viruses can cause a wide range of symptoms, depending on the specific strain and the age and overall health of the infected individual.

The most common types of Coxsackievirus infections are hand, foot, and mouth disease (HFMD) and herpangina. HFMD is characterized by fever, sore throat, and a rash that typically appears on the hands, feet, and mouth. Herpangina is similar but is usually marked by painful sores in the back of the mouth or throat.

Other possible symptoms of Coxsackievirus infections include:

* Fever
* Headache
* Muscle aches
* Fatigue
* Nausea and vomiting
* Abdominal pain

In some cases, Coxsackievirus infections can lead to more serious complications, such as meningitis (inflammation of the membranes surrounding the brain and spinal cord), myocarditis (inflammation of the heart muscle), or pleurodynia (also known as "devil's grip," a painful inflammation of the chest and abdominal muscles).

Coxsackievirus infections are typically spread through close contact with an infected person, such as through respiratory droplets or by touching contaminated surfaces. The viruses can also be spread through fecal-oral transmission.

There is no specific treatment for Coxsackievirus infections, and most people recover on their own within a week or two. However, severe cases may require hospitalization and supportive care, such as fluids and pain relief. Prevention measures include good hygiene practices, such as washing hands frequently and avoiding close contact with sick individuals.

Foot diseases refer to various medical conditions that affect the foot, including its structures such as the bones, joints, muscles, tendons, ligaments, blood vessels, and nerves. These conditions can cause symptoms like pain, swelling, numbness, difficulty walking, and skin changes. Examples of foot diseases include:

1. Plantar fasciitis: inflammation of the band of tissue that connects the heel bone to the toes.
2. Bunions: a bony bump that forms on the joint at the base of the big toe.
3. Hammertoe: a deformity in which the toe is bent at the middle joint, resembling a hammer.
4. Diabetic foot: a group of conditions that can occur in people with diabetes, including nerve damage, poor circulation, and increased risk of infection.
5. Athlete's foot: a fungal infection that affects the skin between the toes and on the soles of the feet.
6. Ingrown toenails: a condition where the corner or side of a toenail grows into the flesh of the toe.
7. Gout: a type of arthritis that causes sudden, severe attacks of pain, swelling, redness, and tenderness in the joints, often starting with the big toe.
8. Foot ulcers: open sores or wounds that can occur on the feet, especially in people with diabetes or poor circulation.
9. Morton's neuroma: a thickening of the tissue around a nerve between the toes, causing pain and numbness.
10. Osteoarthritis: wear and tear of the joints, leading to pain, stiffness, and reduced mobility.

Foot diseases can affect people of all ages and backgrounds, and some may be prevented or managed with proper foot care, hygiene, and appropriate medical treatment.

The term "diabetic foot" refers to a condition that affects the feet of people with diabetes, particularly when the disease is not well-controlled. It is characterized by a combination of nerve damage (neuropathy) and poor circulation (peripheral artery disease) in the feet and lower legs.

Neuropathy can cause numbness, tingling, or pain in the feet, making it difficult for people with diabetes to feel injuries, cuts, blisters, or other foot problems. Poor circulation makes it harder for wounds to heal and increases the risk of infection.

Diabetic foot ulcers are a common complication of diabetic neuropathy and can lead to serious infections, hospitalization, and even amputation if not treated promptly and effectively. Preventive care, including regular foot exams, proper footwear, and good blood glucose control, is essential for people with diabetes to prevent or manage diabetic foot problems.

A disease outbreak is defined as the occurrence of cases of a disease in excess of what would normally be expected in a given time and place. It may affect a small and localized group or a large number of people spread over a wide area, even internationally. An outbreak may be caused by a new agent, a change in the agent's virulence or host susceptibility, or an increase in the size or density of the host population.

Outbreaks can have significant public health and economic impacts, and require prompt investigation and control measures to prevent further spread of the disease. The investigation typically involves identifying the source of the outbreak, determining the mode of transmission, and implementing measures to interrupt the chain of infection. This may include vaccination, isolation or quarantine, and education of the public about the risks and prevention strategies.

Examples of disease outbreaks include foodborne illnesses linked to contaminated food or water, respiratory infections spread through coughing and sneezing, and mosquito-borne diseases such as Zika virus and West Nile virus. Outbreaks can also occur in healthcare settings, such as hospitals and nursing homes, where vulnerable populations may be at increased risk of infection.

"Eleusine" is the genus name for a group of plants that includes several species of grasses, some of which are known as "goosegrass." It does not have a specific medical definition, but certain species of Eleusine may have medicinal or therapeutic uses. For example, in traditional medicine, the leaves and seeds of some Eleusine species have been used to treat various conditions such as diarrhea, dysentery, and skin diseases. However, it is important to note that these uses have not been extensively studied or proven in clinical trials, so they should not be considered medical facts. Always consult with a healthcare provider for medical advice.

Nail diseases, also known as onychopathies, refer to a group of medical conditions that affect the nail unit, which includes the nail plate, nail bed, lunula, and surrounding skin (nail fold). These diseases can be caused by various factors such as fungal infections, bacterial infections, viral infections, systemic diseases, trauma, and neoplasms.

Some common examples of nail diseases include:

1. Onychomycosis - a fungal infection that affects the nail plate and bed, causing discoloration, thickening, and crumbling of the nail.
2. Paronychia - an infection or inflammation of the nail fold, caused by bacteria or fungi, resulting in redness, swelling, and pain.
3. Ingrown toenails - a condition where the nail plate grows into the surrounding skin, causing pain, redness, and infection.
4. Onycholysis - a separation of the nail plate from the nail bed, often caused by trauma or underlying medical conditions.
5. Psoriasis - a systemic disease that can affect the nails, causing pitting, ridging, discoloration, and onycholysis.
6. Lichen planus - an inflammatory condition that can affect the skin and nails, causing nail thinning, ridging, and loss.
7. Melanonychia - a darkening of the nail plate due to pigmentation, which can be benign or malignant.
8. Brittle nails - a condition characterized by weak, thin, and fragile nails that easily break or split.
9. Subungual hematoma - a collection of blood under the nail plate, often caused by trauma, resulting in discoloration and pain.
10. Tumors - abnormal growths that can develop in or around the nail unit, ranging from benign to malignant.

Accurate diagnosis and treatment of nail diseases require a thorough examination and sometimes laboratory tests, such as fungal cultures or skin biopsies. Treatment options vary depending on the underlying cause and may include topical or oral medications, surgical intervention, or lifestyle modifications.

I am not aware of a specific medical definition for the term "China." Generally, it is used to refer to:

1. The People's Republic of China (PRC), which is a country in East Asia. It is the most populous country in the world and the fourth largest by geographical area. Its capital city is Beijing.
2. In a historical context, "China" was used to refer to various dynasties and empires that existed in East Asia over thousands of years. The term "Middle Kingdom" or "Zhongguo" (中国) has been used by the Chinese people to refer to their country for centuries.
3. In a more general sense, "China" can also be used to describe products or goods that originate from or are associated with the People's Republic of China.

If you have a specific context in which you encountered the term "China" related to medicine, please provide it so I can give a more accurate response.

Acquired foot deformities refer to structural abnormalities of the foot that develop after birth, as opposed to congenital foot deformities which are present at birth. These deformities can result from various factors such as trauma, injury, infection, neurological conditions, or complications from a medical condition like diabetes or arthritis.

Examples of acquired foot deformities include:

1. Hammertoe - A deformity where the toe bends downward at the middle joint, resembling a hammer.
2. Claw toe - A more severe form of hammertoe where the toe also curls under, forming a claw-like shape.
3. Mallet toe - A condition where the end joint of a toe is bent downward, causing it to resemble a mallet.
4. Bunions - A bony bump that forms on the inside of the foot at the big toe joint, often causing pain and difficulty wearing shoes.
5. Tailor's bunion (bunionette) - A similar condition to a bunion, but it occurs on the outside of the foot near the little toe joint.
6. Charcot foot - A severe deformity that can occur in people with diabetes or other neurological conditions, characterized by the collapse and dislocation of joints in the foot.
7. Cavus foot - A condition where the arch of the foot is excessively high, causing instability and increasing the risk of ankle injuries.
8. Flatfoot (pes planus) - A deformity where the arch of the foot collapses, leading to pain and difficulty walking.
9. Pronation deformities - Abnormal rotation or tilting of the foot, often causing instability and increasing the risk of injury.

Treatment for acquired foot deformities varies depending on the severity and underlying cause but may include orthotics, physical therapy, medication, or surgery.

Capsid proteins are the structural proteins that make up the capsid, which is the protective shell of a virus. The capsid encloses the viral genome and helps to protect it from degradation and detection by the host's immune system. Capsid proteins are typically arranged in a symmetrical pattern and can self-assemble into the capsid structure when exposed to the viral genome.

The specific arrangement and composition of capsid proteins vary between different types of viruses, and they play important roles in the virus's life cycle, including recognition and binding to host cells, entry into the cell, and release of the viral genome into the host cytoplasm. Capsid proteins can also serve as targets for antiviral therapies and vaccines.

A foot ulcer is a wound or sore on the foot that occurs most commonly in people with diabetes, but can also affect other individuals with poor circulation or nerve damage. These ulcers can be challenging to heal and are prone to infection, making it essential for individuals with foot ulcers to seek medical attention promptly.

Foot ulcers typically develop due to prolonged pressure on bony prominences of the foot, leading to breakdown of the skin and underlying tissues. The development of foot ulcers can be attributed to several factors, including:

1. Neuropathy (nerve damage): This condition causes a loss of sensation in the feet, making it difficult for individuals to feel pain or discomfort associated with pressure points, leading to the formation of ulcers.
2. Peripheral artery disease (PAD): Reduced blood flow to the lower extremities can impair wound healing and make the body more susceptible to infection.
3. Deformities: Structural foot abnormalities, such as bunions or hammertoes, can cause increased pressure on specific areas of the foot, increasing the risk of ulcer formation.
4. Poorly fitting shoes: Shoes that are too tight, narrow, or ill-fitting can create friction and pressure points, contributing to the development of foot ulcers.
5. Trauma: Injuries or trauma to the feet can lead to the formation of ulcers, particularly in individuals with neuropathy who may not feel the initial pain associated with the injury.
6. Foot care neglect: Failure to inspect and care for the feet regularly can result in undetected wounds or sores that progress into ulcers.

Foot ulcers are classified based on their depth, severity, and extent of tissue involvement. Proper assessment, treatment, and prevention strategies are crucial in managing foot ulcers and minimizing the risk of complications such as infection, gangrene, and amputation.

Foot injuries refer to any damage or trauma caused to the various structures of the foot, including the bones, muscles, tendons, ligaments, blood vessels, and nerves. These injuries can result from various causes such as accidents, sports activities, falls, or repetitive stress. Common types of foot injuries include fractures, sprains, strains, contusions, dislocations, and overuse injuries like plantar fasciitis or Achilles tendonitis. Symptoms may vary depending on the type and severity of the injury but often include pain, swelling, bruising, difficulty walking, and reduced range of motion. Proper diagnosis and treatment are crucial to ensure optimal healing and prevent long-term complications.

I apologize for any confusion, but "livestock" is not a term that has a medical definition. It is an agricultural term that refers to animals that are kept or raised on a farm or ranch for commercial purposes, such as the production of food, fiber, or labor. Examples of livestock include cattle, sheep, goats, pigs, poultry, and horses. I hope this clarifies any confusion. If you have any questions related to medical terminology, I would be happy to help.

Opsoclonus-Myoclonus Syndrome (OMS) is a rare neurological disorder characterized by rapid, involuntary, and chaotic eye movements (opsoclonus) and brief, shock-like jerks of the muscles (myoclonus). These symptoms can affect various parts of the body, including the limbs, trunk, and face. OMS is often associated with a variety of underlying causes, such as viral infections, tumors, or autoimmune disorders. In some cases, no specific cause can be identified, and this is referred to as idiopathic OMS.

The symptoms of OMS can significantly impact an individual's daily functioning and quality of life. Treatment typically involves a combination of medications to manage the symptoms and address any underlying causes. The prognosis for individuals with OMS varies depending on the severity of the condition and the effectiveness of treatment. Some people may experience significant improvement in their symptoms, while others may have persistent neurological impairments.

Foot deformities refer to abnormal changes in the structure and/or alignment of the bones, joints, muscles, ligaments, or tendons in the foot, leading to a deviation from the normal shape and function of the foot. These deformities can occur in various parts of the foot, such as the toes, arch, heel, or ankle, and can result in pain, difficulty walking, and reduced mobility. Some common examples of foot deformities include:

1. Hammertoes: A deformity where the toe bends downward at the middle joint, resembling a hammer.
2. Mallet toes: A condition where the end joint of the toe is bent downward, creating a mallet-like shape.
3. Claw toes: A combination of both hammertoes and mallet toes, causing all three joints in the toe to bend abnormally.
4. Bunions: A bony bump that forms on the inside of the foot at the base of the big toe, caused by the misalignment of the big toe joint.
5. Tailor's bunion (bunionette): A similar condition to a bunion but occurring on the outside of the foot, at the base of the little toe.
6. Flat feet (pes planus): A condition where the arch of the foot collapses, causing the entire sole of the foot to come into contact with the ground when standing or walking.
7. High arches (pes cavus): An excessively high arch that doesn't provide enough shock absorption and can lead to pain and instability.
8. Cavus foot: A condition characterized by a very high arch and tight heel cord, often leading to an imbalance in the foot structure and increased risk of ankle injuries.
9. Haglund's deformity: A bony enlargement on the back of the heel, which can cause pain and irritation when wearing shoes.
10. Charcot foot: A severe deformity that occurs due to nerve damage in the foot, leading to weakened bones, joint dislocations, and foot collapse.

Foot deformities can be congenital (present at birth) or acquired (develop later in life) due to various factors such as injury, illness, poor footwear, or abnormal biomechanics. Proper diagnosis, treatment, and management are essential for maintaining foot health and preventing further complications.

Cattle diseases are a range of health conditions that affect cattle, which include but are not limited to:

1. Bovine Respiratory Disease (BRD): Also known as "shipping fever," BRD is a common respiratory illness in feedlot cattle that can be caused by several viruses and bacteria.
2. Bovine Viral Diarrhea (BVD): A viral disease that can cause a variety of symptoms, including diarrhea, fever, and reproductive issues.
3. Johne's Disease: A chronic wasting disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It primarily affects the intestines and can cause severe diarrhea and weight loss.
4. Digital Dermatitis: Also known as "hairy heel warts," this is a highly contagious skin disease that affects the feet of cattle, causing lameness and decreased productivity.
5. Infectious Bovine Keratoconjunctivitis (IBK): Also known as "pinkeye," IBK is a common and contagious eye infection in cattle that can cause blindness if left untreated.
6. Salmonella: A group of bacteria that can cause severe gastrointestinal illness in cattle, including diarrhea, dehydration, and septicemia.
7. Leptospirosis: A bacterial disease that can cause a wide range of symptoms in cattle, including abortion, stillbirths, and kidney damage.
8. Blackleg: A highly fatal bacterial disease that causes rapid death in young cattle. It is caused by Clostridium chauvoei and vaccination is recommended for prevention.
9. Anthrax: A serious infectious disease caused by the bacterium Bacillus anthracis. Cattle can become infected by ingesting spores found in contaminated soil, feed or water.
10. Foot-and-Mouth Disease (FMD): A highly contagious viral disease that affects cloven-hooved animals, including cattle. It is characterized by fever and blisters on the feet, mouth, and teats. FMD is not a threat to human health but can have serious economic consequences for the livestock industry.

It's important to note that many of these diseases can be prevented or controlled through good management practices, such as vaccination, biosecurity measures, and proper nutrition. Regular veterinary care and monitoring are also crucial for early detection and treatment of any potential health issues in your herd.

Phylogeny is the evolutionary history and relationship among biological entities, such as species or genes, based on their shared characteristics. In other words, it refers to the branching pattern of evolution that shows how various organisms have descended from a common ancestor over time. Phylogenetic analysis involves constructing a tree-like diagram called a phylogenetic tree, which depicts the inferred evolutionary relationships among organisms or genes based on molecular sequence data or other types of characters. This information is crucial for understanding the diversity and distribution of life on Earth, as well as for studying the emergence and spread of diseases.

'Foot bones,' also known as the tarsal and metatarsal bones, are the 26 bones that make up the foot in humans. The foot is divided into three parts: the hindfoot, midfoot, and forefoot.

The hindfoot contains two bones: the talus, which connects to the leg bone (tibia), and the calcaneus (heel bone). These bones form the ankle joint and heel.

The midfoot is made up of five irregularly shaped bones called the navicular, cuboid, and three cuneiform bones. These bones help form the arch of the foot and connect the hindfoot to the forefoot.

The forefoot contains the metatarsals (five long bones) and the phalanges (14 small bones). The metatarsals connect the midfoot to the toes, while the phalanges make up the toes themselves.

These bones work together to provide stability, support, and movement for the foot, allowing us to walk, run, and jump.

Aseptic meningitis is a type of meningitis (inflammation of the membranes covering the brain and spinal cord) that is not caused by bacterial infection. Instead, it can be due to viral infections, fungal infections, or non-infectious causes such as certain medications, chemical irritants, or underlying medical conditions. In aseptic meningitis, the cerebrospinal fluid (CSF) analysis may show increased white blood cells, typically lymphocytes, but no bacterial growth on culture. Common viral causes include enteroviruses, herpes simplex virus, and varicella-zoster virus. Treatment depends on the underlying cause and may include supportive care, antiviral medications, or immunosuppressive therapy in some cases.

A viral vaccine is a biological preparation that introduces your body to a specific virus in a way that helps your immune system build up protection against the virus without causing the illness. Viral vaccines can be made from weakened or inactivated forms of the virus, or parts of the virus such as proteins or sugars. Once introduced to the body, the immune system recognizes the virus as foreign and produces an immune response, including the production of antibodies. These antibodies remain in the body and provide immunity against future infection with that specific virus.

Viral vaccines are important tools for preventing infectious diseases caused by viruses, such as influenza, measles, mumps, rubella, polio, hepatitis A and B, rabies, rotavirus, chickenpox, shingles, and some types of cancer. Vaccination programs have led to the control or elimination of many infectious diseases that were once common.

It's important to note that viral vaccines are not effective against bacterial infections, and separate vaccines must be developed for each type of virus. Additionally, because viruses can mutate over time, it is necessary to update some viral vaccines periodically to ensure continued protection.

Mouth diseases refer to a variety of conditions that affect the oral cavity, including the lips, gums, teeth, tongue, palate, and lining of the mouth. These diseases can be caused by bacteria, viruses, fungi, or other organisms. They can also result from injuries, chronic illnesses, or genetic factors.

Some common examples of mouth diseases include dental caries (cavities), periodontal disease (gum disease), oral herpes, candidiasis (thrush), lichen planus, and oral cancer. Symptoms may include pain, swelling, redness, bleeding, bad breath, difficulty swallowing or speaking, and changes in the appearance of the mouth or teeth. Treatment depends on the specific diagnosis and may involve medications, dental procedures, or lifestyle changes.

"Foot joints" is a general term that refers to the various articulations or connections between the bones in the foot. There are several joints in the foot, including:

1. The ankle joint (tibiotalar joint): This is the joint between the tibia and fibula bones of the lower leg and the talus bone of the foot.
2. The subtalar joint (talocalcaneal joint): This is the joint between the talus bone and the calcaneus (heel) bone.
3. The calcaneocuboid joint: This is the joint between the calcaneus bone and the cuboid bone, which is one of the bones in the midfoot.
4. The tarsometatarsal joints (Lisfranc joint): These are the joints that connect the tarsal bones in the midfoot to the metatarsal bones in the forefoot.
5. The metatarsophalangeal joints: These are the joints between the metatarsal bones and the phalanges (toes) in the forefoot.
6. The interphalangeal joints: These are the joints between the phalanges within each toe.

Each of these foot joints plays a specific role in supporting the foot, absorbing shock, and allowing for movement and flexibility during walking and other activities.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

I'm sorry for any confusion, but "Malaysia" is not a medical term or concept. It is a country located in Southeast Asia, consisting of thirteen states and three federal territories. If you have any questions about Malaysia's geography, culture, or people, I would be happy to try to help answer those! However, if you have a question related to medicine or healthcare, please provide more details so I can give you an accurate and helpful response.

I'm sorry for any confusion, but "Singapore" is not a medical term or concept. It is a sovereign city-state and island country in Southeast Asia. If you have any questions related to medical topics or definitions, I would be happy to try and help answer those for you!

A viral RNA (ribonucleic acid) is the genetic material found in certain types of viruses, as opposed to viruses that contain DNA (deoxyribonucleic acid). These viruses are known as RNA viruses. The RNA can be single-stranded or double-stranded and can exist as several different forms, such as positive-sense, negative-sense, or ambisense RNA. Upon infecting a host cell, the viral RNA uses the host's cellular machinery to translate the genetic information into proteins, leading to the production of new virus particles and the continuation of the viral life cycle. Examples of human diseases caused by RNA viruses include influenza, COVID-19 (SARS-CoV-2), hepatitis C, and polio.

DNA Sequence Analysis is the systematic determination of the order of nucleotides in a DNA molecule. It is a critical component of modern molecular biology, genetics, and genetic engineering. The process involves determining the exact order of the four nucleotide bases - adenine (A), guanine (G), cytosine (C), and thymine (T) - in a DNA molecule or fragment. This information is used in various applications such as identifying gene mutations, studying evolutionary relationships, developing molecular markers for breeding, and diagnosing genetic diseases.

The process of DNA Sequence Analysis typically involves several steps, including DNA extraction, PCR amplification (if necessary), purification, sequencing reaction, and electrophoresis. The resulting data is then analyzed using specialized software to determine the exact sequence of nucleotides.

In recent years, high-throughput DNA sequencing technologies have revolutionized the field of genomics, enabling the rapid and cost-effective sequencing of entire genomes. This has led to an explosion of genomic data and new insights into the genetic basis of many diseases and traits.

Neutralizing antibodies are a type of antibody that defends against pathogens such as viruses or bacteria by neutralizing their ability to infect cells. They do this by binding to specific regions on the surface proteins of the pathogen, preventing it from attaching to and entering host cells. This renders the pathogen ineffective and helps to prevent or reduce the severity of infection. Neutralizing antibodies can be produced naturally in response to an infection or vaccination, or they can be generated artificially for therapeutic purposes.

"Cattle" is a term used in the agricultural and veterinary fields to refer to domesticated animals of the genus *Bos*, primarily *Bos taurus* (European cattle) and *Bos indicus* (Zebu). These animals are often raised for meat, milk, leather, and labor. They are also known as bovines or cows (for females), bulls (intact males), and steers/bullocks (castrated males). However, in a strict medical definition, "cattle" does not apply to humans or other animals.

The term "mouth floor" is not a standard medical terminology. However, it might refer to the floor of the mouth, which is the part of the oral cavity located beneath the tongue and above the hyoid bone, which is a U-shaped bone in the front of the neck that helps support the tongue. The mouth floor contains several salivary glands, muscles, and nerves that are important for functions such as swallowing and speaking.

Media related to Hand, foot and mouth disease at Wikimedia Commons Highly contagious Hand, foot and mouth disease killing ... "Treat Hand, Foot, and Mouth Disease". CDC. February 2, 2021. Retrieved October 9, 2021. "Hand Foot and Mouth Disease". CDC. ... "Mysterious deadly illness in Cambodian children tied to hand, foot and mouth disease". Hand, Foot and Mouth Disease. World ... The disease was termed "Hand Foot and Mouth Disease", by Thomas Henry Flewett, after a similar outbreak in 1960. Novel ...
... and hand, foot, and mouth disease. Both group A and group B coxsackieviruses can cause nonspecific febrile illnesses, rashes, ... "Estimation of the basic reproduction number of enterovirus 71 and coxsackievirus A16 in hand, foot, and mouth disease outbreaks ... Interferon has since become prominent in the treatment of a variety of cancers and infectious diseases. In 2007, an outbreak of ... Bornholm disease), and were subdivided into groups A and B based on their pathology in newborn mice. (Coxsackie A virus causes ...
... notable for its role in causing epidemics of severe neurological disease and hand, foot, and mouth disease in children. It was ... "WPRO , Hand, Foot and Mouth Disease (HFMD)". Wpro.who.int. Archived from the original on 2013-10-17. Retrieved 2012-07-28. " ... Of the placebo group, there were 30 cases of hand, foot, and mouth disease (HFMD) reported, and 41 cases of any EV71-associated ... Vietnam recorded 63,780 cases of hand, foot and mouth disease in the first seven months of 2012. According to Tran Minh Dien, ...
Boren, Cindy (August 1, 2018). "Hand, foot and mouth disease strikes again. This time, the Yankees' J. A. Happ is ailing". The ... One week later, Syndergaard was briefly sidelined again after contracting hand, foot, and mouth disease from volunteering at a ... Axson, Scooby (July 22, 2018). "Mets Place Noah Syndergaard On DL With Hand, Foot & Mouth Disease". Sports Illustrated. ... He was placed on the injured list on June 8 as a result of recurring blisters on his pitching hand. On July 26, 2023, the ...
Hand, foot, and mouth disease (HFMD), is a common, often self-limiting viral illness which typically affects infants and ... Saguil A, Kane SF, Lauters R, Mercado MG (October 2019). "Hand-Foot-and-Mouth Disease: Rapid Evidence Review". American Family ... Esposito S, Principi N (March 2018). "Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology ... It is characterized by low grade fever and maculopapular rash on palms of the hands, soles of the feet, and around mouth. It is ...
Viruses portal Animal virology Hand, foot and mouth disease (HFMD) Swine vesicular disease (SVD) Blain, an archaic disease of ... Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral disease that affects ... Foot-and-mouth outbreaks, Animal viral diseases, Bovine diseases, Sheep and goat diseases, Infectious diseases with eradication ... Another viral disease with similar symptoms, hand, foot and mouth disease, occurs more frequently in humans, especially in ...
It is used mainly in the treatment of hand, foot and mouth disease, diarrhea, upper respiratory tract infections and viral ... Systematic review of xiyanping injection for hand foot mouth disease]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = ... Experience of integrated traditional Chinese and Western medicine in first case of imported Zika virus disease in China]". ...
Hand, foot, and mouth disease' associated with Coxsackie A5 virus. J Clin Pathol. 1963 Jan;16:53-5. Kapikian, AZ; Wyatt, RG; ... Although he discovered the cause of hand, foot and mouth disease, the work that gained him an international reputation began in ... Woode was at the Institute for Research on Animal Diseases, Compton, Newbury, Berks. See Flewett T H, Bryden A S, Davies H, ... His laboratory was close to an infectious diseases unit and this enabled him to provide confirmation of the clinical diagnosis ...
On August 2, Happ was placed on the 10-day disabled list due to hand, foot, and mouth (HFM) disease. Happ was activated on ... "J.A. Happ hits DL with hand, foot, mouth disease". MLB. Retrieved August 2, 2018. J.A. Happ » Statistics » Pitching , FanGraphs ... On September 7, the Jays announced that Happ would undergo surgery on a fractured right foot and miss the rest of the season. ... Drellich, Evan (September 7, 2012). "Surgery on foot to end Happ's season". MLB.com. Retrieved September 8, 2012. "Blue Jays ...
"Autopsy Findings in Children with Hand, Foot, and Mouth Disease". New England Journal of Medicine. 367 (1): 91-92. doi:10.1056/ ...
While deployed overseas, twenty members of the crew contracted hand, foot, and mouth disease. In October, Charlottetown took ... Campion-Smith, Bruce (10 August 2016). "Canadian warship hit by outbreak of hand, foot and mouth disease". Toronto Star. ... Russell, Andrew (10 August 2016). "20 Canadian sailors on HMCS Charlottetown contract hand, foot and mouth disease". Global ... "Hundreds on hand to say goodbye to HMCS Charlottetown". The Guardian. 28 June 2016. Archived from the original on 29 June 2016 ...
Repass GL, Palmer WC, Stancampiano FF (September 2014). "Hand, foot, and mouth disease: Identifying and managing an acute viral ... A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... Viruses known to infect humans that have not been associated with disease: the family Anelloviridae and the genus Dependovirus ... This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention ...
660 One cause in children is hand, foot, and mouth disease. This generally resolves without complication. Onychomadesis can ... foot and mouth disease". European Journal of Pediatrics. 160 (11): 649-51. doi:10.1007/s004310100815. PMID 11760019. S2CID ... ISBN 978-0-07-138076-8. Bernier V, Labrèze C, Bury F, Taïeb A (November 2001). "Nail matrix arrest in the course of hand, ... Patterned acquired hypertrichosis List of cutaneous conditions James WD, Berger TG, Elston DM (2006). Andrew's diseases of the ...
In March 2008, an outbreak of hand, foot, and mouth disease began in Fuyang, leading to 25,000 infections, and 42 deaths, by ... Repass GL, Palmer WC, Stancampiano FF (September 2014). "Hand, foot, and mouth disease: Identifying and managing an acute viral ... Some were severely tortured and beaten, having their ears chopped off, their noses dug out, their mouths torn off, and so on, ... The blood collectors would often draw too much blood, causing their feet to go numb, and sometimes people were even hung upside ...
Hand, foot and mouth disease is a childhood illness most commonly caused by infection by Coxsackie A virus or EV71. ... Enterovirus A71 (EV-A71) is notable as one of the major causative agents for hand, foot and mouth disease (HFMD), and is ... Poliovirus Enterovirus C: serotypes PV-1, PV-2, and PV-3. Viruses portal Coxsackievirus Echovirus Hand, foot, and mouth disease ... More intense symptoms of enterovirus include hypoxia, aseptic meningitis, conjunctivitis, hand, foot and mouth disease, and ...
"Hand Foot and Mouth Disease (HFMD) Guidelines" (PDF). Ministry of Health, Malaysia. Archived (PDF) from the original on 29 ... Over 50,000 cases of hand, foot and mouth disease (HFMD) stemming from the Coxsackie virus have been reported since the ... "Situasi Semasa Kejadian Penyakit Tangan, Kaki Dan Mulut (HFMD) Di Malaysia" [Current Situation of Hand, Foot and Mouth Disease ... "Malaysia reports increase in Hand, Foot and Mouth Disease". Outbreak News Today. 10 June 2018. Retrieved 29 August 2019. For ...
"Doctors see hand, foot and mouth disease make comeback in N.B." CBC News. "Severe Respiratory Illnesses Associated with ... "Hand-foot-and-mouth disease outbreaks higher than in years past: AHS - Edmonton , Globalnews.ca". Global News. Retrieved 2022- ... In Canada, warning signs appeared as early as July with a spike in enterovirus ("hand foot and mouth disease") cases which ... Centers for Disease Control and Prevention. 9 September 2022. Archived from the original on 31 October 2022. Retrieved 1 ...
Illnesses and diseases may also include ringworm, head lice, and hand, feet, mouth disease. It is uncertain how these diseases ... Commonly spread diseases include influenza-like illness and enteric illnesses, such as diarrhea among babies using diapers. ... This happens when groups of children meet in a childcare environment, and there is an individual with an infectious disease who ... Warren-Gash, C; Fragaszy, E; Hayward, AC (September 2013). "Hand hygiene to reduce community transmission of influenza and ...
The 1997 Sarawak HFMD outbreak is a hand, foot, and mouth disease (HFMD) outbreak from April until June caused by the ... ISBN 978-0-7808-0458-6. Nur Najihah Hasan (2017). "Assessing the Prevalence of Hand, Foot and Mouth Disease (HFMD) Using ... Enterovirus Portals: Asia Biology Malaysia Medicine Viruses "Hand Foot and Mouth Disease (HFMD) Guidelines" (PDF). Ministry of ... "Deaths of Children during an Outbreak of Hand, Foot, and Mouth Disease in Sarawak, Malaysia: Clinical and Pathological ...
... one cause of hand, foot, and mouth disease 2015 - First vaccine for malaria 2015 - First vaccine for dengue fever 2019 - First ... a new tool to control outbreaks of hand, foot and mouth disease (HFMD)". Expert Review of Vaccines. 15 (5): 599-606. doi: ... Although vaccines exist for the diseases listed below, only smallpox has been eliminated worldwide. The other vaccine- ... First vaccine for Lyme disease 1998 - First vaccine for rotavirus 2000 - First pneumococcal conjugate vaccine approved in the U ...
"Hand, Foot, & Mouth Disease". Sarawak. Archived from the original on 2008-05-12. CDC (2020). "Hand, Foot & Mouth Disease ... The most well known Coxsackie A disease is hand, foot and mouth disease (unrelated to foot-and-mouth disease), a common ... "Hand, Foot and Mouth Disease (HFMD)". Princeton Emergency Management. Retrieved 2020-07-30. "Hand-foot-mouth disease". ... CDC (2020). "Hand, Foot & Mouth Disease Causes". U.S. Centers for Disease Control and Prevention. Retrieved 2020-07-31. Giachè ...
The differential diagnosis includes hand, foot and mouth disease due to similar lesions on the skin. Lymphangioma ... Common infection of the skin or mucosa may affect the face and mouth (orofacial herpes), genitalia (genital herpes), or hands ( ... "Condom Effectiveness - Male Latex Condoms and Sexually Transmitted Diseases". Center for Disease Control and Prevention. ... there was an increase in sexually transmitted diseases. One of the diseases that increased dramatically was genital herpes. In ...
Hand, foot and mouth disease: First vaccine, BBC News, James Gallagher, 28 May 2013 Zhu, Feng-Cai; Meng, Fan-Yue; Li, Jing-Xin ... one cause of hand foot mouth disease, were published, showing a 90% statistically significant efficacy On July 3, 2013, a study ... Refugees are at risk of a variety of health problems, including post-traumatic stress and depression, infectious disease such ...
"Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015". Emerging Infectious Diseases. 24 (3): 432-442. doi: ... "Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, 2011". BMC ... Widespread non-communicable diseases such as cardiovascular disease and cancer are not included. An epidemic is the rapid ... Mad cow disease': What is BSE?". BBC. 18 October 2018. Retrieved 12 May 2020. "Variant Creutzfeldt-Jakob Disease, Current Data ...
"Mets place Noah Syndergaard on the disabled list with hand, foot and mouth disease" by Justin Tasch. The New York Daily News, ...
Hand Foot and Mouth Disease: Similar to herpangina, hand foot and mouth disease occurs predominantly in children. It is caused ... by Coxsackie A and B virus, and lesions or blisters are found bilaterally on the hands, feet and mouth of the patient. Oral ... Prodromal symptoms, such as fever, anorexia, irritability, malaise and headache, may occur in advance of disease. The disease ... Immune system: The prevalence and severity of the disease is dependent on the host's immune response and the virulence of the ...
He is also an expert on enterovirus 71, which causes hand foot and mouth disease and encephalitis. He works on improving the ... He also highlighted the importance of dengue, a related mosquito-borne virus, as a cause of neurological disease. He works on ... Spencer, Ben (30 May 2023). "Disease X is coming. Are we ready for the next pandemic?". ISSN 0140-0460. Retrieved 30 May 2023. ... Three-parent IVF can produce babies free of disease, so let's welcome it". The Guardian. Retrieved 29 May 2015. Solomon, Tom ( ...
Cold sores, hand-foot-mouth disease, and diarrhea are some examples of illnesses easily spread by contaminated fomites. The ... CDC (11 February 2020). "Coronavirus Disease 2019 (COVID-19)". Centers for Disease Control and Prevention. Retrieved 2 February ... Though on hands it survives only for five minutes, the constant contact with a fomite almost certainly means catching the ... "Coronavirus Disease 2019 (COVID-19)". 11 February 2020. Kraay ANM; Hayashi MAL; Berendes, D. M.; Sobolik, J. S.; Leon, J. S.; ...
"Hand, foot and mouth disease at Cutie Kidz Playhouse". MOH, ENV, MCDS. 13 September 2000. Retrieved 27 March 2021. "Hand, foot ... 12 September - Hand, foot, and mouth disease outbreak: The Ministry of the Environment shuts Cutie Kidz Playhouse after a ... "Update on hand, foot and mouth disease". MOH, ENV, MCDS. 15 September 2000. Retrieved 27 March 2021. "Official Opening of ... suspected fatal case of hand, foot and mouth disease (HFMD) two days earlier with four suspect cases later found from the same ...
"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in ... Research is underway to consider the potential of stem cells for treatment of neurodegenerative diseases. There are, however, ... The Journal of Nervous and Mental Disease. 32 (5): 233-44. doi:10.1097/00005053-190504000-00002. Dubreuil CI, Winton MJ, ... Western Australia". Clinical Infectious Diseases. 32 (2): 236-42. doi:10.1086/318454. JSTOR 4482452. PMID 11170913. Langdon FW ...
... hand, foot and mouth disease). Human immunodeficiency virus (HIV) creates immunodeficiencies which allow opportunistic ... Mouth ulcers are very common, occurring in association with many diseases and by many different mechanisms, but usually there ... A wide range of other diseases may cause mouth ulcers. Hematological causes include anemia, hematinic deficiencies, neutropenia ... Other examples of systemic disease capable of causing mouth ulcers include lupus erythematosus, Sweet syndrome, reactive ...

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