Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).

Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. (1/149)

alpha2-antiplasmin (alpha2-AP) is the main physiologic plasmin inhibitor in mammalian plasma. Inactivation of the murine alpha2-AP gene was achieved by replacing, through homologous recombination in embryonic stem cells, a 7-kb genomic sequence encoding the entire murine protein (exon 2 through part of exon 10, including the stop codon) with the neomycin resistance expression cassette. Germline transmission of the mutated allele was confirmed by Southern blot analysis. Mendelian inheritance of the inactivated alpha2-AP allele was observed, and homozygous deficient (alpha2-AP-/-) mice displayed normal fertility, viability, and development. Reverse transcription-polymerase chain reaction confirmed the absence of alpha2-AP mRNA in kidney and liver from alpha2-AP-/- mice, in contrast to wild-type (alpha2-AP+/+) mice. Immunologic and functional alpha2-AP levels were undetectable in plasma of alpha2-AP-/- mice, and were about half of wild-type in heterozygous littermates (alpha2-AP+/-). Other hemostasis parameters, including plasminogen activator inhibitor-1, plasminogen, fibrinogen, hemoglobin, hematocrit, and blood cell counts were comparable for alpha2-AP+/+, alpha2-AP+/-, and alpha2-AP-/- mice. After amputation of tail or toe tips, bleeding stopped spontaneously in alpha2-AP+/+, as well as in alpha2-AP+/- and alpha2-AP-/- mice. Spontaneous lysis after 4 hours of intravenously injected 125I-fibrin-labeled plasma clots was significantly higher in alpha2-AP-/- than in alpha2-AP+/+ mice when injecting clots prepared from alpha2-AP+/+ plasma (78% +/- 5% v 46% +/- 9%; mean +/- SEM, n = 6 to 7; P =.02) or from alpha2-AP-/- plasma (81% +/- 5% v 46% +/- 5%; mean +/- SEM, n = 5; P =.008). Four to 8 hours after endotoxin injection, fibrin deposition in the kidneys was significantly reduced in alpha2-AP-/- mice, as compared with alpha2-AP+/+ mice (P +info)

Annexin II and bleeding in acute promyelocytic leukemia. (2/149)

BACKGROUND: Acute promyelocytic leukemia (APL) is associated with a hemorrhagic disorder of unknown cause that responds to treatment with all-trans-retinoic acid. METHODS: We studied a newly described receptor for fibrinolytic proteins, annexin II, in cells from patients with APL or other leukemias. We examined initial rates of in vitro generation of plasmin by tissue plasminogen activator (t-PA) in the presence of APL cells that did or did not have the characteristic translocation of APL, t(15;17). We also determined the effect of all-trans-retinoic acid on the expression of annexin II and the generation of cell-surface plasmin. RESULTS: The expression of annexin II, as detected by a fluorescein-tagged antibody, was greater on leukemic cells from patients with APL than on other types of leukemic cells (mean fluorescence intensity, 6.9 and 2.9, respectively; P<0.01). The t(15;17)-positive APL cells stimulated the generation of cell-surface, t-PA-dependent plasmin twice as efficiently as the t(15;17)-negative cells. This increase in plasmin was blocked by an anti-annexin II antibody and was induced by transfection of t(15;17)-negative cells with annexin II complementary DNA. The t(15;17)-positive APL cells contained abundant messenger RNA for annexin II, which disappeared through a transcriptional mechanism after treatment with all-trans-retinoic acid. CONCLUSIONS: Abnormally high levels of expression of annexin II on APL cells increase the production of plasmin, a fibrinolytic protein. Overexpression of annexin II may be a mechanism for the hemorrhagic complications of APL.  (+info)

Coagulation and bleeding disorders: review and update. (3/149)

Hemostasis is initiated by injury to the vascular wall, leading to the deposition of platelets adhering to components of the subendothelium. Platelet adhesion requires the presence of von Willebrand factor and platelet receptors (IIb/IIIa and Ib/IX). Additional platelets are recruited to the site of injury by release of platelet granular contents, including ADP. The "platelet plug" is stabilized by interaction with fibrinogen. In this review, I consider laboratory tests used to evaluate coagulation, including prothrombin time, activated partial thromboplastin time, thrombin time, and platelet count. I discuss hereditary disorders of platelets and/or coagulation proteins that lead to clinical bleeding as well as acquired disorders, including disseminated intravascular coagulation and acquired circulating anticoagulants.  (+info)

Reduced oxidative-stress response in red blood cells from p45NFE2-deficient mice. (4/149)

p45NF-E2 is a member of the cap 'n' collar (CNC)-basic leucine zipper family of transcriptional activators that is expressed at high levels in various types of blood cells. Mice deficient in p45NF-E2 that were generated by gene targeting have high mortality from bleeding resulting from severe thrombocytopenia. Surviving p45nf-e2(-/-) adults have mild anemia characterized by hypochromic red blood cells (RBCs), reticulocytosis, and splenomegaly. Erythroid abnormalities in p45nf-e2(-/-) animals were previously attributed to stress erythropoiesis caused by chronic bleeding and, possibly, ineffective erythropoiesis. Previous studies suggested that CNC factors might play essential roles in regulating expression of genes that protect cells against oxidative stress. In this study, we found that p45NF-E2-deficient RBCs have increased levels of reactive oxygen species and an increased susceptibility to oxidative-stress-induced damage. Deformability of p45NF-E2-deficient RBCs was markedly reduced with oxidative stress, and mutant cells had a reduced life span. One possible reason for increased sensitivity to oxidative stress is that catalase levels were reduced in mutant RBCs. These findings suggest a role for p45NF-E2 in the oxidative-stress response in RBCs and indicate that p45NF-E2 deficiency contributes to the anemia in p45nf-e2(-/-) mice. (Blood. 2001;97:2151-2158)  (+info)

Comparison of hemostatic disturbances between patients on CAPD and patients on hemodialysis. (5/149)

OBJECTIVE: Disturbances in hemostasis are common findings in uremic patients. Both bleeding diathesis and thrombosis are observed. The purpose of this study was to assess whether renal replacement therapy in the form of hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD) affects coagulation and fibrinolysis in patients with end-stage renal failure. DESIGN: Comparison of hemostatic measures in patients on CAPD, HD, and matched healthy controls. SETTING: Department of Nephrology and Internal Medicine, Bialystok University School of Medicine. PATIENTS AND METHODS: Twenty-four HD patients and 23 CAPD patients were evaluated with respect to platelet aggregation, hemostatic parameters, serum lipids, lipoprotein(a), and cytokines [tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1)]. INTERVENTIONS: Four exchanges of CAPD per day, using 2.0 L dialysate over a period of 25 +/- 31 months; or 4-5 hours of HD 3 times per week for a period of 31 +/- 22 months. RESULTS: Platelet aggregation in whole blood and platelet-rich plasma was significantly impaired in both groups of dialyzed patients compared to healthy volunteers. Markers of endothelial cell injury (thrombomodulin and von Willebrand factor) were significantly higher in HD and CAPD patients compared to the control group. A similar pattern of changes was observed for lipoprotein(a), fibrinogen, tissue factor pathway activity, and factor VII activity. Activity of factor X was significantly enhanced in CAPD compared to HD patients and controls. Euglobulin clot lysis time was significantly prolonged in HD and CAPD patients over controls, being more prolonged in CAPD patients. Markers of ongoing coagulation (thrombin-antithrombin complexes and prothrombin fragments 1+2) were higher in uremic patients, significantly higher in CAPD than in HD. A marker of ongoing fibrinolysis (plasmin-antiplasmin complexes) was higher in uremic patients but was lower in CAPD than in HD patients. Concentrations of TNFalpha and IL-1 were higher in HD than in CAPD patients. CONCLUSION: Patients on CAPD showed evidence of a higher degree of hypercoagulation than HD patients.Thus, hemostatic abnormalities in end-stage renal failure may be affected to some extent by the choice of renal replacement therapy.  (+info)

Failure of methylhistidines to inhibit platelet aggregation at concentrations found in uremic plasma. (6/149)

Methylhistidines are among the amino acids which are present in increased concentrations in the plasma of severely uremic patients who may have a hemorrhagic diathesis. Histidine contains an imidazole ring, and our previous work has shown inhibition of collagen-induced platelet aggregation by imidazole in concentrations as low as 0.5 mM. Collagen-induced, adenosine diphosphate-induced, and norepinephrine-induced platelet aggregation were tested in platelet-rich plasma by a turbidimetric technique after incubation of the plasma with varying concentrations of the methylhistidines for 1 hour. Platelet aggregation was unaffected by methylhistidine concentrations up to 0.6 mM. Only norepinephrine-induced platelet aggregation was slightly inhibited at a concentration of 4.7 (mM far higher than found in uremic patients). The imidazole ring as a portion of the methylhistidine molecule appears to have lost much of its effect on platelet aggregation.  (+info)

Disseminated intravascular clotting in kwashiorkor. (7/149)

The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with thrombocytopenia, hypofibinogenaemia, and multiple coagulation defects, and with abnormally prolonged partial thromboplastin,prothombin, and thrombin times]. A second goups of 16 patients (7 fatal) showed a less severe grade of DIC manifested by thrombocytopenia, low fibringoen level, and a clotting factor defect shown by rpolonged prothrombin and thrombin times.  (+info)

Orthodontic treatment of patients with medical disorders. (8/149)

This article will highlight some of the problems encountered when orthodontic treatment is provided for patients who have serious medical conditions. The way in which various disease processes might influence treatment decisions will be described, as well as recommended methods of avoiding potential problems.  (+info)

Hemorrhagic disorders are medical conditions characterized by abnormal bleeding due to impaired blood clotting. This can result from deficiencies in coagulation factors, platelet dysfunction, or the use of medications that interfere with normal clotting processes. Examples include hemophilia, von Willebrand disease, and disseminated intravascular coagulation (DIC). Treatment often involves replacing the missing clotting factor or administering medications to help control bleeding.

Flessa, H. C. (December 1974). "Hemorrhagic disorders and pregnancy". Clinical Obstetrics and Gynecology. 17 (4): 236-249. doi: ... Cell membrane disorders: Hereditary spherocytosis Autoimmune causes: lead to the hemolysis of red blood cells (Ex: autoimmune ...
AVMs may occur in isolation or as a part of another disease (for example, Von Hippel-Lindau disease or hereditary hemorrhagic ... Often the malformation is discovered as part of an autopsy or during treatment of an unrelated disorder (an "incidental finding ... They are most commonly associated with hereditary hemorrhagic telangiectasia. AVMs are usually congenital and are part of the ... "A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)". National Institute of Neurological Disorders and ...
Viral hemorrhagic fevers include dengue hemorrhagic fever and dengue shock syndrome. Leukemia may also cause coagulopathy. ... "Treatments for bleeding disorders". Netdoctor. 2015-11-03. Retrieved 2018-09-17. (Webarchive template wayback links, Articles ... "Hemorrhagic diathesis: causes, symptoms, diagnosis, treatment , Competently about health on iLive". iliveok.com. Retrieved 2018 ... Have an early diagnostic test for any blood disorders or blood diseases including hemophilia, hemorrhage, and sickle-cell ...
Webarchive template wayback links, Disorders of conjunctiva, Eye care in Ghana). ... Conjunctiva Corneal limbus REISAKU KONO; APOLLO 11 DISEASE OR ACUTE HEMORRHAGIC CONJUNCTIVITIS: A PANDEMIC OF A NEW ENTEROVIRUS ...
No clinical thrombosis or hemorrhagic event was observed. Horský, Jan; Presl, Jiří (1981). "Hormonal Treatment of Disorders of ... ISBN 978-3-662-00942-0. Horský J, Presl J (1981). "Hormonal Treatment of Disorders of the Menstrual Cycle". In Horsky J, Presl ... 388-. ISBN 978-3-540-38916-3. Andrew N. Margioris; George P. Chrousos (20 April 2001). Adrenal Disorders. Springer Science & ... Studd, J. (2012). "Treatment of premenstrual disorders by suppression of ovulation by transdermal estrogens". Menopause ...
This helps maintain hydration and provides precautions for patients with bleeding disorders. Preventing Omsk Hemorrhagic Fever ... Omsk hemorrhagic fever is a viral hemorrhagic fever caused by a Flavivirus. It was found in Siberia and was named for an ... Omsk hemorrhagic fever is caused by Omsk hemorrhagic fever virus (OHFV), a member of the Flavivirus family. The virus was ... "Omsk hemorrhagic fever (OHF)". Viral Hemorrhagic Fevers (VHFs). Centers for Disease Control and Prevention. 9 December 2013. ( ...
Both coagulant and hemorrhagic activities act in combination, triggering local and systemic hemorrhagic disorders. Proteolytic ... Hemorrhagic activity is caused by metalloproteases, which damage capillary walls. ...
His other research areas included the treatment of burns; management of the severe exfoliating disorders, toxic epidermal ... Alterations in cellular membrane function during hemorrhagic shock in primates. Ann Surg 176: 288-295 (PMID 4627396) (full text ... 1989) Burn unit treatment of acute, severe exfoliating disorders. Annu Rev Med 40: 137-147 (PMID 2658743) Shires GT, Cunningham ... JN, Backer CR et al.. (1972) Alterations in cellular membrane function during hemorrhagic shock in primates. Ann Surg 176: 288- ...
December 2020). "Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia". ... "Hereditary disorder found in Que. families". CTV News. 4 December 2008. Archived from the original on 2008-12-07. "OMIM Entry ... The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the ... There are over 6,000 known genetic disorders in humans. P - Point mutation, or any insertion/deletion entirely inside one gene ...
Envenomation's systemic symptoms include nausea, dizziness, chills, coagulopathy (blood disorders), and shock. Klauber (1997) ... hemorrhagic bleb formation, and ecchymosis (i.e., bruising). Swelling, while not particularly severe, occasionally may involve ...
Conley, C. Lockard (1952). "A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus ...
This complex gives brown color to plasma and occurs in hemolytic and hemorrhagic disorders. Its presence in plasma is used to ... differentiate between hemorrhagic and edematous pancreatitis. The Schumm test is used to differentiate intravascular haemolysis ...
... a syndrome mimicking hereditary hemorrhagic telangiectasia". Bulletin of the Johns Hopkins Hospital 114: 31-83. PMID 14171636. ... An esophageal motility disorder (EMD) is any medical disorder causing difficulty in swallowing, regurgitation of food and a ... Esophageal motility disorder may be a result of CREST syndrome, referring to the five main features: calcinosis, Raynaud ... "Esophageal Motility Disorders - UW Medicine". www.uwmedicine.org. Archived from the original on 2018-09-27. Retrieved 2015-01- ...
A multitude of movement disorders have been observed after either ischemic or hemorrhagic stroke. Some examples include ... endocrine disorders, heritable disorders, vascular disorders, or traumatic disorders. Other causes include toxins within the ... "Movement and Cerebellar Disorders". Neurologic Disorders. Merck Sharp & Dohme Corp. Retrieved 20 March 2011. Eckman, Margaret ( ... ISBN 978-1-930056-30-5. "Hyperkinetic Movement Disorders". Movement Disorders Program. Regents of the University of Michigan. ...
Madden was diagnosed with hereditary hemorrhagic telangiectasia, a rare genetic disorder, during her thirties. In 1974, she ...
... mood disorders, neurodegenerative disorders and schizophrenia); oncology (prostate cancer and hematologic malignancies); ... devices used in the endovascular treatment of hemorrhagic and ischemic stroke; solutions that focus on breast reconstruction ... notably Joseph Biederman and his pediatric bipolar disorder research unit. In 2011, J&J settled litigation brought by the US ...
The fresh bark of the tree is used as an anti-hemorrhagic and applied to wounds. Other uses for the plant are as an emmenagogue ... It is commonly used to treat gynecological disorders such as dysmenorrhea and menorrhagia. Botanic Gardens Conservation ...
... : a disorder of platelet coagulant activity (PCA). Sem Hemat 1994; 31:312-319 Zwaal FA, Comfurius P, Bevers EM. ... Scott syndrome, characterized by impaired transmembrane migration of procoagulant phosphatidylserine and hemorrhagic ... Scott syndrome is a rare congenital bleeding disorder that is due to a defect in a platelet mechanism required for blood ... Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015- ...
Mutations in ALK1 and endoglin cause hereditary hemorrhagic telangiectasia (HHT), a rare but life-threatening genetic disorder ... in GDF2 have been identified in patients with a vascular disorder phenotypically overlapping with hereditary hemorrhagic ... McDonald J, Bayrak-Toydemir P, Pyeritz RE (Jul 2011). "Hereditary hemorrhagic telangiectasia: an overview of diagnosis, ... "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and ...
The brain damage could be an ischemic or an hemorrhagic stroke, or a neurogenerative disorder affecting this region. ... Allotopagnosia is another related disorder in which the patient cannot point at any external targets except his/her own body ... Another patient with heterotopagnosia recovered from this disorder after eight days and offered a narrative of his experience: ... The authors interpreted this disorder as an impairment in the process of pointing itself. O Felician and collaborators ...
... structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders". Blood. 71 (3): 539-555 ...
If a larger dose is consumed, symptoms of a hemorrhagic fever will occur, as well as mental impairment. Other animals are ... susceptible as well, and can experience growth retardation, reproductive disorders, and vomiting if the substance is consumed. ...
... (PTS) is an inherited disorder characterized by mild hemorrhagic tendency associated with 11q ... Genetic disorders with OMIM but no gene, Syndromes, All stub articles, Genetic disorder stubs). ...
"A study of the neurological disorder associated with acute haemorrhagic conjunctivitis due to enterovirus 70". J Neurol ... Wadia has explored neurological manifestations of Acute hemorrhagic conjunctivitis due to enterovirus E 70. He described a new ...
Lancet, ii,985 1938 The normal haemostatic mechanism and its failure in the haemorrhagic states. Thesis for Doctor of Medicine ... 1953 (with R. Biggs) Human Blood Coagulation and its Disorders. Blackwell Scientific Publications, Oxford. 1961 (with A.H.T. ... the treatment of bleeding disorders and to develop replacement therapies that enabled haemophiliacs to enjoy an almost normal ...
"An emerging pulmonary haemorrhagic syndrome in dogs: similar to the human leptospiral pulmonary haemorrhagic syndrome?". ... "284184004: Lepthangamushi syndrome (disorder)". Archived from the original on 18 November 2019. Retrieved 18 November 2019. ... was coined to describe a series of overlapping symptoms of leptospirosis with Hantavirus hemorrhagic fever with renal syndrome ...
In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type ... Some mutations that lead to this disorder are: a Cytosine (C) to Guanine (G) substitution which converts a tyrosine to stop ... GeneReviews/NCBI/NIH/UW entry on Hereditary Hemorrhagic Telangiectasia CD105+Antigen at the U.S. National Library of Medicine ... is the gene for hereditary haemorrhagic telangiectasia type 1" (PDF). Nature Genetics. 8 (4): 345-51. doi:10.1038/ng1294-345. ...
... and hemorrhagic disorders. Anoxia and sepsis are the most frequent causes at birth, while adrenal insufficiency often manifests ... Patients with APS are prone to recurring adrenal vein thrombosis that might cause hemorrhagic infarction of the adrenal gland, ... Other common causes include hemorrhagic diatheses, thromboembolic diseases, blunt trauma, and adrenocorticotropic hormone (ACTH ...
Hemorrhagic strokes can present with a very severe, sudden headache associated with vomiting, neck stiffness, and decreased ... CADASIL is an inherited disorder caused by mutations in the NOTCH3 gene located on chromosome 19. NOTCH3 codes for a ... Arteries supplying oxygen and nutrients to the brain are often damaged or deformed in these disorders. The most common ... Moyamoya is an example of an idiopathic cerebrovascular disorder that results in narrowing and occlusion of intracranial blood ...
... is sometimes described as a slowly progressive disorder with long asymptomatic periods punctuated by thrombotic or hemorrhagic ... which reduces the risk of these thrombotic or hemorrhagic events. The lifespan of a well-controlled ET person is well within ...
Hereditary Hemorrhagic Telangiectasia (HHT) - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - ... Hereditary hemorrhagic telangiectasia is a genetic disorder, which means people pass on the mutated genes to their children. ... Hereditary hemorrhagic telangiectasia is a hereditary disorder in which blood vessels are malformed, making them fragile and ... For example, AVMs that develop in the brain or spinal cord may cause seizures Seizure Disorders In seizure disorders, the ...
Stye see Eyelid Disorders * Subarachnoid Hemorrhage see Hemorrhagic Stroke * Substance Abuse in Pregnancy see Pregnancy and ... Substance use see Alcohol Use Disorder (AUD); Drug Use and Addiction; Drugs and Young People ...
Snow first described acute hemorrhagic edema of infancy (AHEI) as a purely cutaneous variant of Henoch-Schönlein purpura (HSP) ... The cause of acute hemorrhagic edema of infancy (AHEI) is unknown. AHEI is considered to be an immune complex disorder; however ... encoded search term (Acute Hemorrhagic Edema of Infancy) and Acute Hemorrhagic Edema of Infancy What to Read Next on Medscape ... Acute hemorrhagic edema of infancy (AHEI) is more common among male infants than among female infants [6] ; the male-to-female ...
Severe nephropathia epidemica was defined as the occurrence of ,1 of the following criteria: hypovolemic, hemorrhagic, or ... acute kidney injury or hydroelectrolytic disorders requiring dialysis; hemorrhage requiring blood transfusion; admission to the ...
The presence of hemorrhagic bullae in the buccal mucosa and retinal hemorrhages are harbingers of internal and intracranial ... Disorders of Platelet Function. Functional disorders of platelets are relatively rare, and most of these disorders are mild. ... Overview of Platelet Disorders Overview of Platelet Disorders. The hemostatic system consists of platelets, coagulation factors ... Inherited disorders of platelet function are as follows:. * Disorders of platelet adhesion (von Willebrand disease, Bernard- ...
Odds of dying and yearly deaths from Hemorrhagic and hematological disorders of newborn ... Deaths per year from Hemorrhagic and hematological disorders of newborn in the US and one-year odds of dying. Year. Deaths. one ... Lifetime odds of dying from Hemorrhagic and hematological disorders of newborn in the US are 1 in 2,364. ...
Disorders Causing Exudative and Hemorrhagic Detachment > RPE Detachment (Non-AMD ...
Flessa, H. C. (December 1974). "Hemorrhagic disorders and pregnancy". Clinical Obstetrics and Gynecology. 17 (4): 236-249. doi: ... Cell membrane disorders: Hereditary spherocytosis Autoimmune causes: lead to the hemolysis of red blood cells (Ex: autoimmune ...
... ... 2013). The use of US health insurance data for surveillance of rare disorders: hereditary hemorrhagic telangiectasia. 16(1). ... "The use of US health insurance data for surveillance of rare disorders: hereditary hemorrhagic telangiectasia" vol. 16, no. 1, ... "The use of US health insurance data for surveillance of rare disorders: hereditary hemorrhagic telangiectasia" 16, no. 1 (2013) ...
Hepatobiliary & Pancreatic Disorders, Pediatric. Hereditary Hemorrhagic Telangiectasia. High Risk Skin Cancer (Organ ... Memory Disorders. Merkel Cell Carcinoma. Mesothelioma. Metabolic Disorders, Pediatric. Mohs Surgeons. Movement Disorders. Mr ... Blood Disorders, Pediatric. Bone & Mineral Metabolism Disorders, Pediatric. Bone & Spine Metastasis Program. Bone Marrow ... Learning Disorders. Leukemia. Lipid Management. Liver Cancer. Liver Center. Liver Transplant. Lung Cancer. Lung Transplant. ...
Skin and Appendages Disorders: rash erythematous, pruritus, bullous eruption, skin disorder.. Urinary System Disorders: urinary ... A hemorrhagic event should be seriously considered in the presence of an unexplained fall in hematocrit, hemoglobin, or blood ... Myo-, Endo-, Pericardial and Valve Disorders: angina pectoris.. Platelet, Bleeding and Clotting Disorders: hematoma, ... Gastrointestinal System Disorders: flatulence, gastrointestinal disorder (not otherwise specified), dyspepsia.. Heart Rate and ...
Nervous system disorders: Autoimmune encephalitis. Lemtrada. *Cerebrovascular disorders: Stroke, including hemorrhagic and ... Cerebrovascular disorders: Cervicocephalic arterial dissection, stroke, including hemorrhagic and ischemic stroke. * ... Immune system disorders: Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis. *Pulmonary system disorders: Pulmonary ... Immune disorders: Goodpastures syndrome, Graves disease, aplastic anemia, Guillain Barre syndrome, chronic inflammatory ...
Section VII: Digestive Disorders. 50 Gastric Dilatation-Volvulus. -Wayne E. Wingfield. 51 Acute Hemorrhagic Diarrhea. -Timothy ... 60 Thyroid Disorders. -Julia K. Veir and Deborah S. Greco. 61 Parathyroid Disorders. -Kevin A. Hahn. Section IX: Neurologic ... Section VIII: Endocrine Disorders. 58 Adrenal Dsyfunction. -Douglass K. MacIntyre. 59 Pancreatic Disorders: Diabetic ... Section IV: Cardiovascular Disorders. 28 Cardiopulmonary Arrest. -Wayne E. Wingfield. 29 Hemorrhage and Hypovolemia. -Marc R. ...
Official ACG 2020 guideline summary for the management of hepatic and mesenteric circulation disorders. ... Hereditary Hemorrhagic Telangiectasia. LVM Screening. .css-1u94z7f{position:relative;-webkit-transition:margin 150ms cubic- ... Acg clinical guideline: disorders of the hepatic and mesenteric circulation. Am J Gastroenterol. 2020;115(1):18-40. ... Bleeding and Thrombotic Risk in Liver Disorders. Cirrhosis. .css-1u94z7f{position:relative;-webkit-transition:margin 150ms ...
... was initially approved in 2000 for the acute treatment of manic or mixed episodes associated with bipolar disorder, with or ... was approved in 1983 for the treatment of manic episodes associated with bipolar disorder. Depakote DR was subsequently ... Pancreatitis, including fatal hemorrhagic cases.. Depakote (divalproex sodium) delayed-release tablets. Indication 1 - manic ... Adult male and female patients who had a current DSM-IV TR primary diagnosis of bipolar I disorder, manic or mixed type, and ...
... coagulation disorder, or white blood cell disorder. This study is located in New York, New York. ... Do you or your child have a platelet, bleeding, or white blood cell disorder? This study is looking at people who have platelet ... To participate in this study, you must be a child or adult who either is healthy or has a platelet disorder, ... The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. Find ...
... coagulation disorder, or white blood cell disorder. This study is located in New York, New York. ... To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake ... Are you an adult with a diagnosed sleep phase disorder? This study aims to assess the sleep patterns and quality of sleep in ... Do you or your child have a platelet, bleeding, or white blood cell disorder? This study is looking at people who have platelet ...
Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Lung-function; Airway-obstruction; Airway-resistance ... This is also a possible second case of isocyanate hemorrhagic HP as previously described by Roy Patterson et al. ...
These are forms of stroke called hemorrhagic stroke. The bleeding into the brain can cause a wide spectrum of symptoms, from a ... genetic connective tissue disorders that weaken artery walls. *polycystic kidney disease (in which numerous cysts form in the ... The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the ... Clinical trials are studies that allow us to learn more about disorders and improve care. They can help connect patients with ...
... we aimed to analyze the hospitalization costs for immobile patients with hemorrhagic stroke (IHS) or ischemic stroke (IIS) in ... disorders of consciousness; immobility status at discharge; and Charlson Comorbidity Index (CCI) score. CCI was categorized ... Table 3 Multivariate analysis for factors associated with hospitalization costs in immobile patients with hemorrhagic stroke ( ... Liu, H., Zhu, C., Cao, J. et al. Hospitalization costs among immobile patients with hemorrhagic or ischemic stroke in China: a ...
Brain Venous Disorders. *Idiopathic Intracranial Hypertension. *Hereditary Hemorrhagic Telangiectasia. *Pediatric Vascular ...
Gastrointestinal bleeding, hemorrhagic colitis. Cardiac Disorders Arrhythmia. Hepatobiliary Disorders Hepatitis, abnormal liver ... had cardiac disorders, and had chronic airway obstructive disorders, respectively. In this trial, subjects were randomized to ... General disorders and administration site conditions Swelling of the face or tongue, allergy, anaphylactic/anaphylactoid ... Psychiatric Disorders Abnormal behavior, delirium, including symptoms such as hallucinations, agitation, anxiety, altered level ...
Nine of them had a hemorrhagic stroke. One patient had a stroke caused by inflammation in the blood vessels of the brain. ... They found an increasing number of strokes, as well as psychosis and mood disorders suspected to be secondary to the primary ... Coronavirus can cause strokes and mental disorders, new study shows. By Chris Smith ... Psychosis, a neurocognitive dementia-like syndrome, and mood disorders were diagnosed in 23 patients. The researchers think the ...
Dengue haemorrhagic fever. *Seldom but serious complication. *Bleeding. *Potentially, severe coagulation disorders ...
History of autoimmune disorders. · Pancreatitis and ulcerative or hemorrhagic/ischemic colitis and pancreatitis. · Pulmonary ... New or worsening ophthalmologic disorders. · Ischemic and hemorrhagic cerebrovascular events. · Severe decreases in neutrophil ... In many, but not all cases, these disorders resolve after stopping PEGINTRON therapy. Use with Ribavirin: Ribavirin may cause ... WARNING: RISK OF SERIOUS DISORDERS AND RIBAVIRIN-ASSOCIATED EFFECTS. Alpha interferons, including PEGINTRON, may cause or ...
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation ... hemorrhagic events, and nephrotoxicity induced by NSAID [18]; infusion hypersensitivity reactions, and auto-immune responses (e ... Dragos D, Gilca M, Gaman L, Vlad A, Iosif L, Stoian I, Lupescu O. Phytomedicine in Joint Disorders. Nutrients. 2017; 9(1):70. ... Dragos D, Gilca M, Gaman L, Vlad A, Iosif L, Stoian I, Lupescu O. Phytomedicine in Joint Disorders. Nutrients. 2017; 9(1):70. ...
  • A ruptured aneurysm can cause serious health problems such as hemorrhagic stroke, brain damage, coma, and even death. (nih.gov)
  • In this study, we aimed to analyze the hospitalization costs for immobile patients with hemorrhagic stroke (IHS) or ischemic stroke (IIS) in China and to determine the factors associated with hospitalization costs. (biomedcentral.com)
  • Strange coronavirus symptoms have been observed since the pandemic started, including brain complications like stroke or psychiatric disorders. (bgr.com)
  • Nine of them had a hemorrhagic stroke. (bgr.com)
  • Causes of cerebrovascular disorders include ischaemic and haemorrhagic stroke and malformations in the brain's arteries or veins. (nature.com)
  • This animation shows the difference between an ischemic stroke and a hemorrhagic stroke. (visiblebody.com)
  • Anterior and posterior segments, together with neuro-ophthalmic disorders were found among stroke patients in this study. (who.int)
  • Ocular disorders among stroke patients. (who.int)
  • Thirty-nine patients (47.0%) were dearth of information on the pattern of ocular between ages of 51 and 60, while 1 (1.2%) was disorders in patients with stroke. (who.int)
  • The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of patients that is most likely to benefit. (uclahealth.org)
  • However, there is currently no effective targeted therapy for hemorrhagic stroke. (medscape.com)
  • They are first-line agents for acute BP reduction in hemorrhagic stroke, but they are second-line agents for stroke prevention. (medscape.com)
  • Hereditary hemorrhagic telangiectasia (also called Osler-Weber-Rendu syndrome) is a hereditary disorder of vascular malformation. (merckmanuals.com)
  • Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
  • Overview of Platelet Disorders Platelets are circulating cell fragments that function in the clotting system. (merckmanuals.com)
  • To participate in this study, you must be a child or adult who either is healthy or has a platelet disorder, coagulation disorder, or white blood cell disorder. (nih.gov)
  • Overview of Vascular Bleeding Disorders Bleeding may result from abnormalities in Platelets Coagulation factors Blood vessels Vascular bleeding disorders result from defects in blood vessels, typically causing cutaneous or mucosal. (merckmanuals.com)
  • Disorders of coagulation can be acquired or hereditary. (merckmanuals.com)
  • Because all coagulation factors are made in the liver (by hepatocytes and hepatic sinusoidal endothelial cells), both the prothrombin time (PT) and partial thromboplastin time (PTT) are prolonged in severe liver disorders. (merckmanuals.com)
  • Obstructive Shock (Massive Pulmonary Embolism) Hemorrhagic Shock (Blood Products Therapy). (muni.cz)
  • To assess the utility of US health insurance data for surveillance of hereditary hemorrhagic telangiectasia, an autosomal-dominant blood vasculature disorder with an estimated prevalence of 1.5-2.0 per 10,000 persons worldwide. (cdc.gov)
  • Osler-Weber-Rendu disease, also referred to as hereditary haemorrhagic telangiectasia, A 63-year-old Iranian man who complained is a genetic disease, an autosomal dominant of fatigue, pale appearance, weakness and disorder characterized by telangiectasias asthenia was the proband case. (who.int)
  • Hemophilia Hemophilias are common hereditary bleeding disorders caused by deficiencies of either clotting factor VIII or IX. (merckmanuals.com)
  • Normal results on initial tests exclude many bleeding disorders. (merckmanuals.com)
  • Patients are at risk for thrombotic and hemorrhagic events. (medscape.com)
  • Electrolytes Disorders (Hyperkalemia, hypo- and hypernatremia) Nutrition in Intensive Care Acute Renal Failure -Acute Kidney Injury (Renal Replacement Therapy (IHD x CRRT)) Acute Liver Failure (Approach, differential diagnostics and management) Hospital Acquired Infection (Definition). (muni.cz)
  • To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. (nih.gov)
  • Psychosis, a neurocognitive dementia-like syndrome, and mood disorders were diagnosed in 23 patients. (bgr.com)
  • In some cases, however, it can worsen and lead to a haemorrhagic syndrome, with a fatality rate of up to 30% in some countries. (anses.fr)
  • A disorder that causes leg discomfort and an irresistible urge to move the legs ( restless legs syndrome or RLS). (webmd.com)
  • Cytogenetic studies detect the presence or absence of the Philadelphia chromosome and help to differentiate myeloproliferative disorders from myelodysplastic syndrome. (medscape.com)
  • Hereditary hemorrhagic telangiectasia is a hereditary disorder in which blood vessels are malformed, making them fragile and prone to bleeding. (msdmanuals.com)
  • It turns out that researchers are looking at ways in which different wavelengths of light could help medical professionals treat brain injuries and disorders (like traumatic brain injury and Alzheimer's Disease) as well as migraines and chronic pain. (visiblebody.com)
  • Massive Bleeding (Life-Threatening Hemorrhage) Disorders of Consciousness (Definition, differential diagnostics, management). (muni.cz)
  • COL4A1 -related disorders are characterized by a higher incidence of cerebral hemorrhage than other hereditary cerebral small vessel diseases. (nature.com)
  • This tick, which thrives in dry climates and warm weather, can transmit Crimean-Congo haemorrhagic fever (CCHF). (anses.fr)
  • Find out more about possible emergence of Crimean-Congo haemorrhagic fever in France . (anses.fr)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • Monitor closely in patients who are risk for, or who have a history of cardiac ischemia, thromboembolic events, hemorrhagic events. (renalandurologynews.com)
  • Patients with this disorder have small red-to-violet lesions on the face, lips, oral and nasal mucosa, and tips of the fingers and toes. (merckmanuals.com)
  • Without treatment, the disease can cause skin, muscle, neurological and joint disorders that can be highly disabling. (anses.fr)
  • Benzene also causes a life-threatening disorder called aplastic anemia in humans and animals. (cdc.gov)
  • Large cockade (rosette or knot of ribbons), annular, or targetoid purpuric lesions found primarily on the face, ears, and extremities are characteristic of acute hemorrhagic edema of infancy. (medscape.com)
  • Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
  • Contraindicated during pregnancy, or with hemorrhagic disorders. (chineseherbsdirect.com)
  • Fatty liver of pregnancy Hepatic disorders in pregnancy may be Unique to pregnancy Preexisting Coincident with pregnancy and possibly exacerbated by pregnancy Jaundice may result from nonobstetric or obstetric conditions. (merckmanuals.com)
  • This article reviews an inherited disorder, hereditary hemorrhagic telangiectasia, in the context of a complicated clinical case. (wjgnet.com)
  • Hence, primary hemostatic disorders are characterized by prolonged bleeding time, and the characteristic physical examination findings are petechiae and purpura. (medscape.com)
  • The prevalence of anoestrus was 18.5% (83 out of 448 cows) as reported by the farmers with silent estrus 53.0% (n = 44), true anoestrus 42.2% (n = 35), cystic ovarian disease 2.4% (n = 2) and uterine infections 2.4% (n = 2) as the underlying disorders. (scialert.net)
  • Although, the significant effects of postpartum anoestrus are well known, the prevalence of underlying disorders and effective remedies in Bangladeshi crossbred cows is not well studied. (scialert.net)
  • Hence, the objectives of this study were to determine the prevalence of underlying disorders and to evaluate the effective treatment of the postpartum anoestrus in crossbred dairy cows. (scialert.net)
  • They found an increasing number of strokes, as well as psychosis and mood disorders suspected to be secondary to the primary disease. (bgr.com)
  • Placenta previa is, like placental abruption, a hemorrhagic disorder. (millerandzois.com)
  • Heart Failure (HF) Heart failure is a disorder in which the heart is unable to keep up with the demands of the body, leading to reduced blood flow, back-up (congestion) of blood in the veins and lungs, and/or. (msdmanuals.com)
  • Do you or your child have a platelet, bleeding, or white blood cell disorder? (nih.gov)
  • This study is looking at people who have platelet or other blood disorders. (nih.gov)
  • This disorder is characterized by reduction of all cellular elements in the peripheral blood and in bone marrow, leading to fibrosis, an irreversible replacement of bone marrow. (cdc.gov)
  • Cerebrovascular disorders are a group of pathological conditions in which impaired blood flow to the brain affects its function. (nature.com)
  • Hereditary hemorrhagic telangiectasia is a genetic disorder, which means people pass on the mutated genes to their children. (msdmanuals.com)
  • They are also at risk of developing secondary acute leukemia from their underlying disorder, as well as from their treatment. (medscape.com)
  • Diagnosis was finally determined disorders such as heart or renal failure or through dermatological consultation. (who.int)
  • The biggest indication of placental abruption, another hemorrhagic disorder, is painful bleeding. (millerandzois.com)
  • Liver failure is caused by a disorder or substance that damages the liver. (msdmanuals.com)
  • Acute hemorrhagic edema of infancy (AHEI) has been reported in countries throughout the world, although incidence is unknown. (medscape.com)
  • Circadian rhythm disorders can cause overweight and obesity. (nih.gov)