Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).
A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.
Tumors or cancer of the SPLEEN.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.
A naturally occurring phenomenon where terminally differentiated cells dedifferentiate to the point where they can switch CELL LINEAGES. The cells then differentiate into other cell types.
Virus diseases caused by the HERPESVIRIDAE.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Malignant histiocytosis in cattle. (1/78)

Malignant histiocytosis was diagnosed in 4 cows. In all cases the tumor tissues were composed of cytologically atypical histiocytes with evidence of erythrophagocytosis. The tumor in case 1 appeared highly anaplastic with marked nuclear pleomorphism, and had areas of spindle cell differentiation, but had no relation to malignant fibrous histiocytoma. The neoplastic tissue in case 2, characterized by cohesive growth of tumor cells, was distinguishable from anaplastic carcinoma cells by cytokeratin immunostaining. There were many hemosiderin-laden neoplastic cells suggestive of high phagocytic activity in a lymph node of case 3. The neoplastic cells in case 4, frequently multinucleated, were less atypical than in the other cases. All cases expressed histiocyte-associated markers (lysozyme and HAM56), and were negative for cytokeratin, S100, and T- and B-cell lineage-specific markers (CD3 and CD79a). The most frequent HAM56 immunoreactivity was detected in case 4, and the giant, multinucleated forms, reminiscent of epithelioid cell differentiation. seemed not to indicate cytological pleomorphism as a result of neoplastic transformation.  (+info)

Diffuse leptomeningeal malignant histiocytosis in the brain and spinal cord of a Tibetan Terrier. (2/78)

An 8-year-old male Tibetan Terrier showed prolonged astasia, complete paralysis, ticlike signs, and seizure and died 2 months after the onset of symptoms. Histopathologically, there was moderate to severe infiltration of pleomorphic histiocytic mononuclear cells bilaterally in the basiarachnoidal and ventricular areas of the brain. The spinal dura mater, arachnoidal space, and leptomeninges were also affected by infiltrative proliferation of these mononuclear cells. The infiltrating cells had the morphologic characteristics of histiocytes but exhibited moderate pleomorphism and atypia, with abundant mitotic figures. With immunohistochemistry and lectin histochemistry, most of the infiltrating cells were positive for lysozyme and lectin RCA-1 and negative for glial fibrillary acid protein, suggesting that they were of monocytic/histiocytic-origin. Positive proliferating cell nuclear antigen immunostaining demonstrated that most nuclei of the histiocytic cells were in the S phase of the cell cycle, consistent with a proliferating population of cells. Based on these findings, the case was diagnosed as diffuse leptomeningeal malignant histiocytosis.  (+info)

Cutaneous histiocytic lesions: a clinical dilemma. (3/78)

The diagnosis of malignant histiocytosis requires a high index of clinical suspicion, awareness of its atypical features and availability of various tissue samples for morphological and special studies. The case reported here highlights the diagnostic difficulties encountered in a patient diagnosed as malignant histiocytosis who presented with cutaneous lesions in multiple foci, which included the face, groin and forearm. Only after repeated biopsies and special stains, a diagnosis of malignant histiocytosis was arrived at. Chemotherapy with CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisone) was initiated. The response to chemotherapy was good and the patient is doing well eleven months after initial diagnosis.  (+info)

Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. (4/78)

Canine histiocytic proliferative disorders include a wide spectrum of diseases characterized by different biologic behaviors. The etiology and pathogenesis of these diseases are largely unknown. The clinicopathologic, morphologic and immunophenotypic characteristics of canine localized and disseminated histiocytic sarcoma were examined in 39 dogs. Rottweilers, Bernese Mountain Dogs, and retrievers were most commonly affected (79%). Localized histiocytic sarcomas (19 dogs) arose from a single site, and metastatic lesions were observed in draining lymph nodes. Predilection sites were subcutis and underlying tissues on extremities, but tumors occurred in other locations, including spleen, lung, brain, nasal cavity, and bone marrow. Disseminated histiocytic sarcomas (20 dogs), a multisystem disease previously described as malignant histiocytosis, primarily affected spleen, lungs, bone marrow, liver, and lymph nodes. Both localized and disseminated canine histiocytic sarcomas were composed of pleomorphic tumor cell populations. CD1+, CD4-, CD11c+, CD11d-, MHC II+, ICAM-1 +, Thy-1 +/- tumor cells were identified in all snap-frozen samples (31 dogs). This phenotype is characteristic for myeloid dendritic antigen-presenting cell lineage. Hence, canine localized and disseminated histiocytic sarcomas are likely myeloid dendritic cell sarcomas. Dendritic antigen-presenting cells are a heterogeneous cell population with regards to their ontogeny, phenotype, function, and localization. The exact sublineage of the proliferating dendritic antigen-presenting cells involved in canine histiocytic sarcomas remains to be determined. Phenotypic analysis of formalin-fixed tissues from eight dogs was limited by available markers. Morphologic features and the phenotype CD18+, CD3-, and CD79a- were the most useful criteria to indicate likely histiocytic origin.  (+info)

Lymphomas of true histiocytic origin. Expression of different phenotypes in so-called true histiocytic lymphoma and malignant histiocytosis. (5/78)

The authors determined the phenotypes of neoplastic cells in true histiocytic lymphoma and malignant histiocytosis by using a large panel of monoclonal antibodies and enzyme histochemistry procedures. Although the phenotypes overlapped slightly, the authors noted a distinct pattern in these tumors. The tumor cells of malignant histiocytosis generally expressed the monocyte markers CD11b, CD11c, CD14, and CD45, especially after induction with phorbol ester. In contrast, the tumor cells of true histiocytic lymphoma exhibited a marker expression very similar to that of Reed-Sternberg cells in Hodgkin's disease. These cells expressed markers CD30, 2H9, and 1A2, but rarely expressed CD11b, CD11c, CD14, or CD45. Regardless of their cytologic features, the tumor cells from both types of histiocytic lymphoma exhibited diffuse nonspecific esterase and acid phosphatase activities, and they expressed histiocyte markers CD15, CD68, LN5, 1E9, and M387 to varying degrees. The tumor cells from both lymphomas did not exhibit T- or B-cell markers, T-cell receptor or immunoglobulin gene rearrangements, or gene translation products, even when they were induced with phorbol ester. The phenotypic expression in these two histiocytic malignancies suggests that they are derived from different types of histiocytes, or from histiocytes in different stages of maturation or differentiation, or from histiocytes that have distinct mechanisms of tumorigenic transformation. The expression of circulating monocyte markers in malignant histiocytosis suggests that this tumor originates in monocytes or free histiocytes, whereas the phenotype of true histiocytic lymphoma is compatible with an origin in fixed histiocytes, which generally are devoid of the monocyte markers CD11b and CD14.  (+info)

Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture. (6/78)

Malignant histiocytosis is a rare invasive proliferation of neoplastic histiocytes. Cases previously reported as malignant histiocytosis were shown to be lymphomas of T or B lineage, especially anaplastic large-cell lymphomas. A case of malignant histiocytosis is described, in which a patient presenting with symptoms suggestive of pneumonia suddenly deteriorated and died. At autopsy, a large quantity of fresh blood, originating from several ruptured nodules on the enlarged spleen, was seen in the peritoneal cavity. Extensive infiltration by pleomorphic tumour cells and erythrophagocytosis by tumour cells were seen on histological examination of the spleen. Immunohistochemical analysis and staining were carried out. This is the second reported case of malignant histiocytosis presenting with spontaneous splenic rupture.  (+info)

Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis. (7/78)

In humans, malignant histiocytosis is a tumour-like disease characterised by increasing proliferation of macrophages and reinforced degradation of erythrocytes. High progression of this disease leads to an unfavourable prognosis for the patients, most of them children up to the age of three years. Histological and cytological findings have proposed an important role of aberrant expression of cytokines in histiocytosis. Due to the fact that Bernese Mountain Dogs (BMD) show a predisposition for spontaneously developing malignant histiocytosis, these dogs could possibly be used as a genetic model organism to elucidate the mechanisms of human malignant histiocytosis. Canine cytokine cDNA transcripts of TNFalpha, Interleukin-1-alpha (IL-1alpha) and Interleukin-1-beta (IL-1beta) were screened for single nucleotide polymorphisms (SNPs). SNP screening in canine cytokine transcripts for malignant histiocytosis has not been carried out before. Total RNA was isolated from tissue samples from lung, spleen, testis and skin of 17 different dogs (fifteen BMDs, one Collie and one West Highland Terrier). The corresponding cytokine cDNAs were amplified, sequenced and then screened for SNPs. The resulting effects on the protein sequence were analysed. Several BMDs and the West Highland Terrier showed SNPs in the coding sequences which led to missense mutations within the protein sequences of TNFalpha, IL1alpha and IL1beta.  (+info)

Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. (8/78)

Podoplanin, recognized by monoclonal antibody D2-40, may be a useful marker for follicular dendritic cell (FDC) tumors. Paraffin sections of 125 dendritic cell, histiocytic, and spindle cell lesions were studied, including 11 FDC tumors, 5 interdigitating dendritic cell tumors, 10 histiocytic sarcomas, 5 Langerhans cell histiocytosis, 5 sinus histiocytosis with massive lymphadenopathy, 5 inflammatory pseudotumors of lymph node or spleen, 9 nodal Kaposi sarcomas, 6 inflammatory myofibroblastic tumors (IMTs), 29 gastrointestinal stromal tumors (GISTs), and 10 cases each of malignant peripheral nerve sheath tumor, leiomyosarcoma, monophasic synovial sarcoma (SS), and solitary fibrous tumor. All FDC tumors and Kaposi sarcomas showed strong immunoreactivity for podoplanin (predominantly membranous). Podoplanin expression was only occasionally observed in the other tumor types, including 7 GISTs (24%), 2 IMTs (33%), and 3 SS (30%), and was generally weak and cytoplasmic. Reactivity for podoplanin was more common in spindle cell GISTs (5/13 [38%]) than in epithelioid or mixed-type GISTs (2/16 [13%]). Podoplanin is a highly sensitive marker for FDC tumors and may be useful to help confirm the diagnosis in conjunction with conventional FDC markers, particularly in the differential diagnosis of dendritic cell and histiocytic lesions.  (+info)

Histiocytic sarcoma is a rare type of cancer that originates from histiocytes, which are cells that are part of the immune system and found in various tissues throughout the body. These cells normally function to help fight infection and remove foreign substances. In histiocytic sarcoma, there is an abnormal accumulation and proliferation of these cells, leading to the formation of tumors.

Histiocytic sarcoma can affect people of any age but is more commonly found in adults, with a slight male predominance. It can occur in various parts of the body, such as the lymph nodes, skin, soft tissues, and internal organs like the spleen, liver, and lungs. The exact cause of histiocytic sarcoma remains unknown, but it is not considered to be hereditary.

The symptoms of histiocytic sarcoma depend on the location and extent of the tumor(s). Common signs include swollen lymph nodes, fatigue, fever, weight loss, night sweats, and pain or discomfort in the affected area. Diagnosis typically involves a combination of imaging studies (like CT scans, PET scans, or MRI), biopsies, and laboratory tests to confirm the presence of histiocytic sarcoma and assess its extent.

Treatment for histiocytic sarcoma usually involves a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. The choice of treatment depends on several factors, such as the location and stage of the disease, the patient's overall health, and their personal preferences. Clinical trials may also be an option for some patients, allowing them to access new and experimental therapies.

Prognosis for histiocytic sarcoma is generally poor, with a five-year survival rate of approximately 15-30%. However, outcomes can vary significantly depending on individual factors, such as the patient's age, the extent of the disease at diagnosis, and the effectiveness of treatment. Continued research is necessary to improve our understanding of this rare cancer and develop more effective therapies for those affected.

Malignant histiocytic disorders are a group of rare and aggressive cancers that affect the mononuclear phagocyte system, which includes histiocytes or cells that originate from bone marrow precursors called monoblasts. These disorders are characterized by the uncontrolled proliferation of malignant histiocytes, leading to tissue invasion and damage.

There are several types of malignant histiocytic disorders, including:

1. Acute Monocytic Leukemia (AML-M5): This is a subtype of acute myeloid leukemia that affects the monocyte cell lineage and can involve the skin, lymph nodes, and other organs.
2. Langerhans Cell Histiocytosis (LCH): Although primarily considered a benign histiocytic disorder, some cases of LCH can progress to a malignant form with aggressive behavior and poor prognosis.
3. Malignant Histiocytosis (MH): This is a rare and aggressive disorder characterized by the infiltration of malignant histiocytes into various organs, including the liver, spleen, and lymph nodes.
4. Histiocytic Sarcoma (HS): This is a highly aggressive cancer that arises from malignant histiocytes and can affect various organs, such as the skin, lymph nodes, and soft tissues.

Symptoms of malignant histiocytic disorders depend on the type and extent of organ involvement but may include fever, fatigue, weight loss, anemia, and enlarged lymph nodes or organs. Treatment typically involves a combination of chemotherapy, radiation therapy, and/or stem cell transplantation. The prognosis for malignant histiocytic disorders is generally poor, with a high risk of relapse and a low overall survival rate.

Sarcoma is a type of cancer that develops from certain types of connective tissue (such as muscle, fat, fibrous tissue, blood vessels, or nerves) found throughout the body. It can occur in any part of the body, but it most commonly occurs in the arms, legs, chest, and abdomen.

Sarcomas are classified into two main groups: bone sarcomas and soft tissue sarcomas. Bone sarcomas develop in the bones, while soft tissue sarcomas develop in the soft tissues of the body, such as muscles, tendons, ligaments, fat, blood vessels, and nerves.

Sarcomas can be further classified into many subtypes based on their specific characteristics, such as the type of tissue they originate from, their genetic makeup, and their appearance under a microscope. The different subtypes of sarcoma have varying symptoms, prognoses, and treatment options.

Overall, sarcomas are relatively rare cancers, accounting for less than 1% of all cancer diagnoses in the United States each year. However, they can be aggressive and may require intensive treatment, such as surgery, radiation therapy, and chemotherapy.

Histiocytes are a type of immune cell that are part of the mononuclear phagocyte system. They originate from monocytes, which are derived from hematopoietic stem cells in the bone marrow. Histiocytes play an important role in the immune system by engulfing and destroying foreign substances, such as bacteria and viruses, as well as removing dead cells and other debris from the body. They can be found in various tissues throughout the body, including the skin, lymph nodes, spleen, and liver.

Histiocytes include several different types of cells, such as macrophages, dendritic cells, and Langerhans cells. These cells have different functions but all play a role in the immune response. For example, macrophages are involved in inflammation and tissue repair, while dendritic cells are important for presenting antigens to T cells and initiating an immune response.

Abnormal accumulations or dysfunction of histiocytes can lead to various diseases, such as histiocytosis, which is a group of disorders characterized by the abnormal proliferation and accumulation of histiocytes in various tissues.

'Hyalin' is not a medical condition or disease, but rather a histological term used to describe a particular type of tissue structure. Hyalin refers to the homogeneous, translucent, and eosinophilic (pink) appearance of a tissue under a microscope due to the accumulation of an amorphous, acellular, and protein-rich matrix.

Hyalinization can occur in various tissues, including blood vessels, cardiac valves, cartilage, and other connective tissues. It is often associated with aging, injury, inflammation, or degenerative changes, such as those seen in hyaline membrane disease (a respiratory disorder in premature infants) or hypertrophic cardiomyopathy (thickening of the heart muscle).

In summary, Hyalin is a histological term used to describe the appearance of tissue under a microscope due to the accumulation of an amorphous, acellular, and protein-rich matrix.

Splenic neoplasms refer to abnormal growths or tumors in the spleen, which can be benign (non-cancerous) or malignant (cancerous). These growths can arise from various cell types present within the spleen, including hematopoietic cells (red and white blood cells, platelets), stromal cells (supporting tissue), or lymphoid cells (part of the immune system).

There are several types of splenic neoplasms:

1. Hematologic malignancies: These are cancers that affect the blood and bone marrow, such as leukemias, lymphomas, and multiple myeloma. They often involve the spleen, causing enlargement (splenomegaly) and neoplastic infiltration of splenic tissue.
2. Primary splenic tumors: These are rare and include benign lesions like hemangiomas, lymphangiomas, and hamartomas, as well as malignant tumors such as angiosarcoma, littoral cell angiosarcoma, and primary splenic lymphoma.
3. Metastatic splenic tumors: These occur when cancer cells from other primary sites spread (metastasize) to the spleen. Common sources of metastasis include lung, breast, colon, and ovarian cancers, as well as melanomas and sarcomas.

Symptoms of splenic neoplasms may vary depending on the type and extent of the disease but often include abdominal pain or discomfort, fatigue, weight loss, and anemia. Diagnosis typically involves imaging studies (such as ultrasound, CT, or MRI scans) and sometimes requires a biopsy for confirmation. Treatment options depend on the type of neoplasm and may include surgery, chemotherapy, radiation therapy, targeted therapy, or immunotherapy.

There is no medical definition for "dog diseases" as it is too broad a term. However, dogs can suffer from various health conditions and illnesses that are specific to their species or similar to those found in humans. Some common categories of dog diseases include:

1. Infectious Diseases: These are caused by viruses, bacteria, fungi, or parasites. Examples include distemper, parvovirus, kennel cough, Lyme disease, and heartworms.
2. Hereditary/Genetic Disorders: Some dogs may inherit certain genetic disorders from their parents. Examples include hip dysplasia, elbow dysplasia, progressive retinal atrophy (PRA), and degenerative myelopathy.
3. Age-Related Diseases: As dogs age, they become more susceptible to various health issues. Common age-related diseases in dogs include arthritis, dental disease, cancer, and cognitive dysfunction syndrome (CDS).
4. Nutritional Disorders: Malnutrition or improper feeding can lead to various health problems in dogs. Examples include obesity, malnutrition, and vitamin deficiencies.
5. Environmental Diseases: These are caused by exposure to environmental factors such as toxins, allergens, or extreme temperatures. Examples include heatstroke, frostbite, and toxicities from ingesting harmful substances.
6. Neurological Disorders: Dogs can suffer from various neurological conditions that affect their nervous system. Examples include epilepsy, intervertebral disc disease (IVDD), and vestibular disease.
7. Behavioral Disorders: Some dogs may develop behavioral issues due to various factors such as anxiety, fear, or aggression. Examples include separation anxiety, noise phobias, and resource guarding.

It's important to note that regular veterinary care, proper nutrition, exercise, and preventative measures can help reduce the risk of many dog diseases.

I'm sorry for any confusion, but "Sarcoma, Experimental" is not a recognized medical term or definition. Sarcomas are a type of cancer that develop in the body's connective tissues, such as bones, muscles, tendons, cartilage, and fat. There are many different types of sarcomas, classified based on the specific type of tissue they originate from.

Experimental, on the other hand, refers to something that is being tested or tried out for the first time, typically as part of a scientific experiment or clinical trial. In the context of cancer treatment, an experimental therapy might refer to a new drug, procedure, or device that is still being studied in clinical trials to determine its safety and effectiveness.

Therefore, "Sarcoma, Experimental" could potentially refer to a clinical trial or research study involving a new treatment for sarcoma, but it would not be a medical definition in and of itself. If you have any specific questions about sarcomas or experimental treatments, I would recommend consulting with a healthcare professional or medical researcher for more accurate information.

Antigens are substances (usually proteins) on the surface of cells, or viruses, bacteria, and other microorganisms, that can stimulate an immune response.

Differentiation in the context of myelomonocytic cells refers to the process by which these cells mature and develop into specific types of immune cells, such as monocytes, macrophages, and neutrophils.

Myelomonocytic cells are a type of white blood cell that originate from stem cells in the bone marrow. They give rise to two main types of immune cells: monocytes and granulocytes (which include neutrophils, eosinophils, and basophils).

Therefore, 'Antigens, Differentiation, Myelomonocytic' refers to the study or examination of how antigens affect the differentiation process of myelomonocytic cells into specific types of immune cells. This is an important area of research in immunology and hematology as it relates to understanding how the body responds to infections, inflammation, and cancer.

I believe there might be a misunderstanding in your question. "Dogs" is not a medical term or condition. It is the common name for a domesticated carnivore of the family Canidae, specifically the genus Canis, which includes wolves, foxes, and other extant and extinct species of mammals. Dogs are often kept as pets and companions, and they have been bred in a wide variety of forms and sizes for different purposes, such as hunting, herding, guarding, assisting police and military forces, and providing companionship and emotional support.

If you meant to ask about a specific medical condition or term related to dogs, please provide more context so I can give you an accurate answer.

Muramidase, also known as lysozyme, is an enzyme that hydrolyzes the glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan, a polymer found in bacterial cell walls. This enzymatic activity plays a crucial role in the innate immune system by contributing to the destruction of invading bacteria. Muramidase is widely distributed in various tissues and bodily fluids, such as tears, saliva, and milk, and is also found in several types of white blood cells, including neutrophils and monocytes.

Ewing sarcoma is a type of cancer that originates in bones or the soft tissues surrounding them, such as muscles and tendons. It primarily affects children and adolescents, although it can occur in adults as well. The disease is characterized by small, round tumor cells that typically grow quickly and are prone to metastasize (spread) to other parts of the body, most commonly the lungs, bones, and bone marrow.

Ewing sarcoma is caused by a genetic abnormality, specifically a chromosomal translocation that results in the fusion of two genes, EWSR1 and FLI1. This gene fusion leads to the formation of an abnormal protein that disrupts normal cell growth and division processes, ultimately resulting in cancer.

Symptoms of Ewing sarcoma can vary depending on the location and size of the tumor but may include pain or swelling in the affected area, fever, fatigue, and weight loss. Diagnosis typically involves imaging studies such as X-rays, CT scans, or MRI scans to locate the tumor, followed by a biopsy to confirm the presence of cancer cells. Treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these approaches, depending on the stage and location of the disease.

Synovial sarcoma is a rare type of cancer that typically develops in the soft tissues surrounding the joints, such as the synovial membrane, which lines the joint capsules. Despite its name, synovial sarcoma does not necessarily arise from the synovium. It is called so due to its resemblance to this tissue under a microscope.

This form of sarcoma primarily affects young adults and can be found in various parts of the body, but it most commonly occurs in the extremities, particularly near the knees. Synovial sarcoma is characterized by specific genetic changes that result in the formation of fusion proteins, which contribute to uncontrolled cell growth and tumor development.

There are two main subtypes of synovial sarcoma: monophasic and biphasic. Monophasic synovial sarcoma is composed of either spindle-shaped (spaghetti-like) cells or epithelioid (roundish) cells, while biphasic synovial sarcoma contains both types of cells. A third subtype, called poorly differentiated synovial sarcoma, has a more aggressive behavior and is composed of small round cells that do not resemble the typical spindle or epithelioid cells.

Treatment for synovial sarcoma usually involves surgical removal of the tumor, often followed by radiation therapy and/or chemotherapy to reduce the risk of recurrence and metastasis. The prognosis varies depending on factors such as the size and location of the tumor, the patient's age, and the presence of metastases at diagnosis.

Kaposi sarcoma (KS) is a type of cancer that causes abnormal growths in the skin, lymph nodes, or other organs. It is caused by the Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). There are several forms of KS, including:

1. Classic KS: This form primarily affects older men of Mediterranean, Middle Eastern, or Ashkenazi Jewish descent. It tends to progress slowly and mainly involves the skin.
2. Endemic KS: Found in parts of Africa, this form predominantly affects children and young adults, regardless of their HIV status.
3. Immunosuppression-associated KS: This form is more aggressive and occurs in people with weakened immune systems due to organ transplantation or other causes.
4. Epidemic KS (AIDS-related KS): This is the most common form of KS, seen primarily in people with HIV/AIDS. The widespread use of antiretroviral therapy (ART) has significantly reduced its incidence.

KS lesions can appear as red, purple, or brown spots on the skin and may also affect internal organs such as the lungs, lymph nodes, or gastrointestinal tract. Symptoms vary depending on the location of the lesions but often include fever, fatigue, weight loss, and swelling in the legs or abdomen. Treatment options depend on the extent and severity of the disease and may involve local therapies (e.g., radiation, topical treatments), systemic therapies (e.g., chemotherapy, immunotherapy), or a combination of these approaches.

Medical Definition of "Herpesvirus 8, Human" (HHV-8):

Human Herpesvirus 8 (HHV-8), also known as Kaposi's Sarcoma-associated Herpesvirus (KSHV), is a DNA virus from the family of Herpesviridae. It is the causative agent of several malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). HHV-8 is primarily transmitted through saliva, sexual contact, or organ transplantation. In immunocompromised individuals, such as those with HIV/AIDS, the risk of HHV-8-associated malignancies significantly increases. The virus establishes latency in infected cells and can periodically reactivate, causing inflammation and potentially leading to the development of cancer.

Giant lymph node hyperplasia, also known as Castlemans disease, is a rare benign condition characterized by the abnormal enlargement of lymph nodes due to an overgrowth of cells. It can affect people of any age but is more commonly seen in young adults and children.

The enlarged lymph nodes caused by this condition are typically round, firm, and mobile, and they may be found in various locations throughout the body, including the neck, chest, abdomen, and pelvis. In some cases, the enlarged lymph nodes may cause symptoms such as pain, pressure, or difficulty swallowing, depending on their location.

Giant lymph node hyperplasia can be classified into two main types: unicentric and multicentric. Unicentric Castleman's disease affects a single group of lymph nodes, while multicentric Castleman's disease affects multiple groups of lymph nodes throughout the body.

The exact cause of giant lymph node hyperplasia is not fully understood, but it is thought to be related to an overactive immune response. In some cases, it may be associated with viral infections such as HIV or HHV-8. Treatment for this condition typically involves surgical removal of the affected lymph nodes, along with medications to manage any associated symptoms and prevent recurrence.

Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that typically presents as an effusion (accumulation of fluid) in the pleural, pericardial, or peritoneal cavities without a detectable tumor mass. It is strongly associated with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) and often occurs in people with weakened immune systems, such as those with HIV/AIDS. The malignant cells in PEL are typically large B-cells that secrete fluid, leading to the formation of effusions. This type of lymphoma is aggressive and has a poor prognosis.

Cell transdifferentiation is a process in which one type of differentiated cell transforms into another type of differentiated cell, without going through the stage of pluripotent stem cells. This process involves a series of genetic and epigenetic changes that result in the activation of new genetic programs and repression of old ones, leading to the acquisition of a new cell identity.

Transdifferentiation is a rare event in nature, but it has been induced in the laboratory through various methods such as gene transfer, chemical treatment, or nuclear transplantation. This process has potential applications in regenerative medicine, tissue engineering, and disease modeling. However, it also raises ethical concerns related to the generation of chimeric organisms and the possibility of uncontrolled cell growth.

Herpesviridae infections refer to diseases caused by the Herpesviridae family of double-stranded DNA viruses, which include herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8). These viruses can cause a variety of clinical manifestations, ranging from mild skin lesions to severe systemic diseases.

After the initial infection, these viruses typically become latent in various tissues and may reactivate later in life, causing recurrent symptoms. The clinical presentation of Herpesviridae infections depends on the specific virus and the immune status of the host. Common manifestations include oral or genital ulcers (HSV-1 and HSV-2), chickenpox and shingles (VZV), mononucleosis (CMV), roseola (HHV-6), and Kaposi's sarcoma (HHV-8).

Preventive measures include avoiding close contact with infected individuals during the active phase of the infection, practicing safe sex, and avoiding sharing personal items that may come into contact with infectious lesions. Antiviral medications are available to treat Herpesviridae infections and reduce the severity and duration of symptoms.

B-lymphocytes, also known as B-cells, are a type of white blood cell that plays a key role in the immune system's response to infection. They are responsible for producing antibodies, which are proteins that help to neutralize or destroy pathogens such as bacteria and viruses.

When a B-lymphocyte encounters a pathogen, it becomes activated and begins to divide and differentiate into plasma cells, which produce and secrete large amounts of antibodies specific to the antigens on the surface of the pathogen. These antibodies bind to the pathogen, marking it for destruction by other immune cells such as neutrophils and macrophages.

B-lymphocytes also have a role in presenting antigens to T-lymphocytes, another type of white blood cell involved in the immune response. This helps to stimulate the activation and proliferation of T-lymphocytes, which can then go on to destroy infected cells or help to coordinate the overall immune response.

Overall, B-lymphocytes are an essential part of the adaptive immune system, providing long-lasting immunity to previously encountered pathogens and helping to protect against future infections.

Yoshida C, Takeuchi M (2008). "Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry". ... Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can appear in the thyroid. ... De Vos FY, Gerding MN, Arends JW, Wegman JJ (August 2008). "Histiocytic sarcoma localised in the thyroid: a case report". Ann. ... Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS (May 2005). "Histiocytic sarcoma: a study of five ...
... Diffuse histiocytic sarcoma Localized histiocytic sarcoma Malignant diseases of macrophages Histiocytic ... A similar disease is diffuse histiocytic sarcoma, a term used to designate a localized histiocytic sarcoma that has spread ... Affolter V, Moore P (2002). "Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs". Vet Pathol. 39 ( ... Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) ...
Histiocytic sarcoma Localized histiocytic sarcoma Diffuse histiocytic sarcoma Histiocytoma is a common, benign, cutaneous ... Histiocytic neoplasia which originates at a single site is called histiocytic sarcoma. This form of histiocytic sarcoma, which ... The histiocytic sarcoma (HS) complex encompasses a number of distinctive clinical entities which will be described below. Some ... Pathologists diagnosed histiocytic sarcoma in these instances and prognosis was reported as poor. In 3 instances regression of ...
... and histiocytic sarcoma in Bernese Mountain Dogs. Pedigree analysis of Bernese Mountain Dogs in France showed that only 5.5% of ... and Genetics of Histiocytic Sarcoma in the Bernese Mountain Dog Breed". Journal of Heredity. 100 (Suppl 1): S19-S27. doi: ...
July 2010). "Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental ... classification of histiocytic sarcoma". International Journal of Hematology. 92 (1): 168-73. doi:10.1007/s12185-010-0603-z. ...
... with diffuse histiocytic sarcoma". Front Microbiol. 5: 655. doi:10.3389/fmicb.2014.00655. PMC 4249460. PMID 25520709. Kerr, ...
... locus present in the founder of Bernese mountain dogs around 200 years ago predisposes the breed to histiocytic sarcoma ...
The breed is also prone to histiocytic sarcoma, a cancer of the muscle tissue that is very aggressive, and hereditary eye ...
... associated lymphoproliferative disorders Histiocytic and dendritic cell neoplasms Histiocytic sarcoma Langerhans cell ... cell sarcoma Indeterminate dendritic cell tumour Interdigitating dendritic cell sarcoma Follicular dendritic cell sarcoma ... mastocytosis with an associated hematological neoplasm Aggressive systemic mastocytosis Mast cell leukaemia Mast cell sarcoma ... leukaemia Acute megakaryoblastic leukaemia Acute basophilic leukaemia Acute panmyelosis with myelofibrosis Myeloid sarcoma ...
... or histiocytic sarcoma. t-FL is almost always diagnosed in patients being followed for FL. These FL patients present with the: ... or histiocytic sarcoma. Other findings indicating the presence of this transformation include rapid growth in size of lymph ...
9.2.2 Rosai-Dorfman disease 9.2.3 Juvenile xanthogranuloma 9.2.4 Langerhans cell histiocytosis 9.2.5 Histiocytic sarcoma 10.1 ... FET-CREB fusion-positive 7.1.4.2 CIC-rearranged sarcoma 7.1.4.3 Primary intracranial sarcoma, DICER1-mutant 7.1.4.4 Ewing ... 9.1.2.4 T-cell and NK/T-cell lymphomas 9.2 Histiocytic tumors 9.2.1 Erdheim-Chester disease ... sarcoma 7.2 Chondro-osseous tumours 7.2.1 Chondrogenic tumours 7.2.1.1 Mesenchymal chondrosarcoma 7.2.1.2 Chondrosarcoma 7.2.2 ...
... canine transmissible venereal sarcoma (CTVS), sticker tumor and infectious sarcoma, is a histiocytic tumor of the external ... Canine transmissible venereal tumors are histiocytic tumors that may be transmitted among dogs through coitus, licking, biting ... and contagious reticulum cell sarcoma of the Syrian hamster. The tumor cells are themselves the infectious agents, and the ...
Bernese Mountain Dogs Diffuse histiocytic sarcoma Localized histiocytic sarcoma Malignant diseases of macrophages Histiocytic ... Histiocytoma from The Pet Health Library Histiocytoma and Histiocytic Sarcoma in Cats and Dogs from Pet Cancer Center Photos of ... Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. They include the following: ... "Tumors with Histiocytic Differentiation". The Merck Veterinary Manual. 2006. Retrieved 2007-04-29. Ginhoux F, Tacke F, Angeli V ...
Kaposi sarcoma African lymphadenopathic Kaposi sarcoma Aggressive infantile fibromatosis AIDS-associated Kaposi sarcoma Ainhum ... histiocytic medullary reticulosis) Marginal zone B-cell lymphoma Mucosa-associated lymphoid tissue lymphoma Mycosis fungoides ... Granulocytic sarcoma (chloroma, myeloid sarcoma) Granulomatous slack skin Hairy-cell leukemia Hodgkin's disease Ichthyosis ... Aagenaes syndrome Acroangiodermatitis (acroangiodermatitis of Mali, Mali acroangiodermatitis, Pseudo-Kaposi's sarcoma) ...
DFSP accounts for between 1 and 6 percent of all soft-tissue sarcomas and 18 percent of all cutaneous soft-tissue sarcomas. In ... plexiform structure of tumour DFSP formed both by fibroblastic and histiocytic elements Hemosiderin deposits beneath the tumour ... R. W. Taylor, in 1890, first identified DFSP as a keloid sarcoma. Later in 1924, Ferdinand-Jean Darier and Ferrand identified ... About 90% of DFSPs are low-grade sarcomas. About 10% are mixed, containing a high-grade sarcomatous component (DFSP-FS); ...
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma is a variant of follicular dendritic cell sarcoma ... This category of EBV+ LPD is heterogeneous, involving EBV-infected B cells, T cells, and/or histiocytic/dendritic cells. These ... Dalia S, Shao H, Sagatys E, Cualing H, Sokol L (October 2014). "Dendritic cell and histiocytic neoplasms: biology, diagnosis, ... Wu A, Pullarkat S (February 2016). "Follicular Dendritic Cell Sarcoma". Archives of Pathology & Laboratory Medicine. 140 (2): ...
... mast-cell sarcoma MeSH C15.604.744.293 - hypersplenism MeSH C15.604.744.428 - myeloid metaplasia MeSH C15.604.744.617 - splenic ... histiocytic disorders, malignant MeSH C15.604.667.400.390.400 - histiocytosis, malignant MeSH C15.604.667.400.390.500 - ... histiocytic necrotizing lymphadenitis MeSH C15.604.315.618 - mesenteric lymphadenitis MeSH C15.604.315.809 - tuberculosis, ...
Kaposi's Sarcoma (KS) is an extremely common disease that arises in AIDS patients and HIV-infected individuals. The condition ... or any cancer of lymphoreticular or histiocytic tissue, or angioimmunoblastic lymphoadenopathy or been diagnosed with a genetic ... In recent years, however, incidences of Kaposi's sarcoma in the United States have dwindled so much that physicians today often ... The remaining types of KS are known as Classic (Mediterranean), Endemic (African), and Transplant-related Kaposi's Sarcoma. ...
Kaposi's sarcoma Lymphoma Burkitt's, immunoblastic or primary brain Mycobacterium avium complex Mycobacterium, other species, ... or any cancer of lymphoreticular or histiocytic tissue, or angioimmunoblastic lymphoadenopathy OR a genetic immunodeficiency ...
... clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance - clinical series - clinical ... histiocytic lymphoma - histologic examination - histology - histone - histone deacetylase - historic cohort study - historical ... spindle cell sarcoma - spiral CT scan - splenomegaly - sputum cytology - squalamine lactate - squamous cell - squamous cell ... soft tissue sarcoma - solar keratosis - solid tumor - somatic cell - somatic mutation - somnolence syndrome - sonogram - ...
... sarcoma 176.0 Kaposi's sarcoma skin 176.1 Kaposi's sarcoma soft tissue 176.2 Kaposi's sarcoma palate 176.3 Kaposi's sarcoma ... Peripheral T-cell lymphoma 202.8 Other lymphomas 202.9 Other and unspecified malignant neoplasms of lymphoid and histiocytic ... 176.4 Kaposi's sarcoma 176.5 Kaposi's sarcoma lymph nodes 176.8 Kaposi's sarcoma other specified sites 176.9 Kaposi's sarcoma ... site unspecified Ewing's sarcoma Osteosarcoma Chondrosarcoma 171 Malignant neoplasm of connective and other soft tissue ...
The human form of OSM was originally isolated in 1986 from the growth media of PMA treated U-937 histiocytic lymphoma cells by ... OSM is a major growth factor for Kaposi's sarcoma "spindle cells", which are of endothelial origin. These cells do not express ... Murakami-Mori K, Taga T, Kishimoto T, Nakamura S (September 1995). "AIDS-associated Kaposi's sarcoma (KS) cells express ... a growth regulator produced by differentiated histiocytic lymphoma cells". Proc. Natl. Acad. Sci. U.S.A. 83 (24): 9739-43. ...
X M9755/3 Histiocytic sarcoma True histiocytic lymphoma M9756/3 Langerhans cell sarcoma M9757/3 Dendritic cell sarcoma, NOS ... Pleomorphic cell sarcoma M8803/3 Small cell sarcoma Round cell sarcoma M8804/3 Epithelioid sarcoma Epithelioid cell sarcoma ... NOS Endometrial sarcoma, NOS Endometrial stromal sarcoma, high grade M8931/3 Endometrial stromal sarcoma, low grade ... spindle cell Synovial sarcoma, monophasic fibrous M9042/3 Synovial sarcoma, epithelioid cell M9043/3 Synovial sarcoma, biphasic ...
However caution is employed since a majority of recurrent tumors with transformations to the malignant sarcoma phenotype have ... In contrast, the mononuclear histiocytic cells (MNHC) and multinucleated giant cell (MNGC) fractions are secondarily recruited ... can transform to the malignant sarcoma phenotype with equal disease outcome. Large cell Aneurysmal bone cyst Pai SB, Lalitha RM ...
Renne, R; Zhong, W; Herndier, B; McGrath, M; Abbey, N; Kedes, D; Ganem, D (March 1996). "Lytic growth of Kaposi's sarcoma- ... Sundström C (May 1976). "Establishment and characterization of a human histiocytic lymphoma cell line (U-937)". Int. J. Cancer ... I. Establishment in continuous cell culture and heterotransplantation of diffuse histiocytic lymphomas". Cancer. 34 (6): 1851- ... harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus". Blood. 88 (7): 2648-54. ...
Myeloid sarcoma is also considered a subtype of AML independently of the blast count. The older French-American-British (FAB) ... Myeloid and Histiocytic/Dendritic Neoplasms". Leukemia. 36 (7): 1703-1719. doi:10.1038/s41375-022-01613-1. PMC 9252913. PMID ...
Yoshida C, Takeuchi M (2008). "Histiocytic sarcoma: identification of its histiocytic origin using immunohistochemistry". ... Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can appear in the thyroid. ... De Vos FY, Gerding MN, Arends JW, Wegman JJ (August 2008). "Histiocytic sarcoma localised in the thyroid: a case report". Ann. ... Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS (May 2005). "Histiocytic sarcoma: a study of five ...
Histiocytic Sarcoma or malignant histiocytosis. is the most prevalent cancer in the breed. Studies are ongoing to attempt to ... Histiocytic Sarcoma has been shown to be inherited. How cancers are inherited is not known, although a polygenic mode of ... Histiocytic Sarcoma has been shown to be inherited. How cancers are inherited is not known, although a polygenic mode of ...
Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. ... 5, 6] Although several histiocytic disorders are briefly discussed in this article (see History), the primary focus is on ... Kikuchis histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn ... Histiocytic diseases include disorders of dendritic cells, ie, Langerhans cell histiocytosis (LCH); abnormal multiplication of ...
This is the first case report of Histiocytic Sarcoma (HS) with predominant spindle cell component occurring in the head and ... Histiocytic sarcoma. Axial CT scan showing a destructive lesion of the left mandible with invasion of the surrounding ... From: Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component ...
Histiocytic and dendritic cell neoplasms. **Histiocytic sarcoma. *Langerhans cell histiocytosis. *Langerhans cell sarcoma ...
IntroductionHistocytic sarcoma is a rare malignant tumor of histiocytes that may involve any organ system, although central ...
Histiocytic sarcoma. *Hemangiosarcoma. *Lymphoma. *Sarcoma. This evidence strongly supports the value of having your dog or ...
Macrophage/Histiocytic neoplasms. Histiocytic sarcoma Dendritic Cell Neoplasms Langerhans Cell Tumor. Langerhans Cell Sarcoma. ... SARCOMA, LANGERHANS Histiocytic sarcoma with secondary involvement of the skin and expression of CD1a: evidence of ... In the current nosology of histiocytic neoplasms, histiocytic sarcoma is separate from indeterminate cell histiocytosis, a ... Background: Histiocytic sarcoma is an exceedingly rare malignant neoplasm composed of cells with a monocyte/macrophage ...
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma. Strain. C57BL/10J. Tumor Inducing Agent(s). None ( ... Model DetailsLeukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma. Model Name. ...
Hepatic Undifferentiated Embryonal Sarcoma Sun Aug 16, 2009 4:20 pm. ruelostogi. 2. histiocytic sarcoma Fri Nov 06, 2009 11:43 ...
histiocytic sarcoma Fri May 08, 2009 10:19 am. lilienjieh21. 1. Adenoid cystic carcinoma Tue Aug 25, 2009 4:26 am. ... Acral Myxoinflammatory Fibroblastic Sarcoma Wed Aug 04, 2010 5:04 pm. cherylm. 49. Muscinous adenocarcinoma of the appendix Fri ...
Histiocyte histiocytic sarcoma Abdominal cavity. Model Name. Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma ...
Histiocytic Sarcoma in Dogs. $198.00 Add to Cart. * Incontinence in Dogs. $99.00 Add to Cart ...
Learn more about pediatric research studies related to neurofibromatosis sarcoma MPNST relapse / refractory at Cincinnati ... or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/o ...More ... or Histiocytic Disorders * Ages: 12 Months to 21 Years ...
Presumptive histiocytic sarcoma in a great horned owl (Bubo virginianus). J Zoo Wildl Med 1992; 23: 113-121. ... Presumptive histiocytic sarcoma in a great horned owl (Bubo virginianus). J Zoo Wildl Med 1992; 23: 113-121. ... Presumptive histiocytic sarcoma in a great horned owl (Bubo virginianus). J Zoo Wildl Med 1992; 23: 113-121. ... Presumptive histiocytic sarcoma in a great horned owl (Bubo virginianus). . J Zoo Wildl Med. 1992. ; 23. : 113. -. 121. .. ), ...
Histiocytic sarcoma. ND. Germ cell tumors. Mature teratoma. ND. Immature teratoma. ND ...
Histiocytic Sarcoma Genetic Risk Test. SPECIALTY CLINIC. Tested. May 08, 2019. OFA. Elbows. BMD-EL13699M24-VPI. Normal. Dec 16 ...
Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic ... Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases ... Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. ... Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice. ...
Histiocytic Sarcoma + Metastatic Infiltration of the Bone Marrow + Posttheraupetic a Posttransplant Hematopoietic Changes + ...
Histiocytic, and Related Cutaneous Tumors in Animals. Find specific details on this topic and related topics from the Merck Vet ... reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. Although their derivation was ... Tumors with Histiocytic Differentiation Tumors with histiocytic differentiation comprise a group of poorly defined skin ... Lymphocytic, Histiocytic, and Related Cutaneous Tumors in Animals By Alice E. Villalobos , DVM, Pawspice & Animal Oncology ...
Histiocytic sarcomas. *Primary lung malignancies. *Lymphoma. *Granulomatous disorders. *Vasculitis. *Chronic obstructive ... Malignancy (primary bone, metastasis to bone, lymphoma, Ewing sarcoma, multiple myeloma, chordoma) ...
Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling.. Kordes ... Impact of dynamic 18F-FDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after ... Dose-intensive chemotherapy with stem cell support as a treatment strategy for bone and soft-tissue sarcomas.. Kasper B, Ho AD ... Positron emission tomography as a tool for early prediction of therapy outcome in soft tissue sarcoma.. Kasper B, Schmitt T, ...
... diffuse histiocytic lymphoma, and microglioma. The proliferation of names reflects initial uncertainty about the cell of origin ... This is the same herpes virus that is associated with Kaposi sarcoma and with primary effusion (ie, body-cavity-based lymphomas ... 6] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic ... Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse ...
Sarcoma, Soft Tissue, & Rare Bone Tumors. Carcinosarcima, chondrosarcoma, epithelioid, hemangiopericytoma, histiocytic, ... Askins tumor, Ewings sarcoma, extraosseous sarcoma, primitive neuroectodermal tumor, PNET 6 Topics. 17 Posts. Last post. by ... Clear Cell Sarcoma. aka: malignant melanoma of soft parts, soft tissue melanoma, melanoma of tendons & aponeuroses 4 Topics. 27 ... sarcoma; Tongue, tonsil , and trachea cancers, 40 Topics. 226 Posts. Last post. by Lisamarie306 Wed Feb 16, 2022 2:21 pm ...
Sarcoma, Soft Tissue, & Rare Bone Tumors. Carcinosarcima, chondrosarcoma, epithelioid, hemangiopericytoma, histiocytic, ... Askins tumor, Ewings sarcoma, extraosseous sarcoma, primitive neuroectodermal tumor, PNET 6 Topics. 17 Posts. Last post. by ... Clear Cell Sarcoma. aka: malignant melanoma of soft parts, soft tissue melanoma, melanoma of tendons & aponeuroses 4 Topics. 27 ... sarcoma; Tongue, tonsil , and trachea cancers, 40 Topics. 226 Posts. Last post. by Lisamarie306 Wed Feb 16, 2022 2:21 pm ...
Histiocytic sarcoma. C96.Z. Other specified malignant neoplasms of lymphoid, hematopoietic and related tissue. ... Sarcoma of dendritic cells (accessory cells). C96.9. Malignant neoplasm of lymphoid, hematopoietic and related tissue, ...
High Frequency of Clonal Immunoglobulin Receptor Gene Rearrangements in Histiocytic/Dendritic Sarcomas: Molecular Study of 24 " ... Mast Cell Sarcoma: Report of 5 Cases with Review of the Literature. Modern Pathol. 33(Suppl 2):1344-1345A (Abstract #1428, [ ...
  • Kaposi sarcoma herpesvirus (KSHV) is specifically associated with Kaposi sarcoma (KS) and 2 B cell lymphoproliferative diseases, namely primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). (jci.org)
  • Primary central nervous system lymphoma (PCNSL) has been known by many other names, including reticulum cell sarcoma, diffuse histiocytic lymphoma, and microglioma. (medscape.com)
  • [ 6 ] Additionally, a biopsy of lymphoma pre-treated with corticosteroids may reveal only gliosis or lymphocytic and histiocytic infiltrates without identifiable neoplastic cells. (medscape.com)
  • Volition's Nu.Q® Vet Cancer Test detected 76% of systemic cancers ( including lymphoma, hemangiosarcoma, and histiocytic sarcoma) at 97% specificity versus control. (volition.com)
  • CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. (thermofisher.com)
  • However, when it comes to cancer they have a higher than average risk of developing a number of different cancers including soft tissue sarcomas, osteosarcoma (bone cancer), lymphoma, mast cell tumors, transitional cell carcinomas (bladder cancer) and hemangiosarcomas (cancer of the blood vessels). (vmsg.com)
  • [ 5 , 6 ] Although several histiocytic disorders are briefly discussed in this article (see History ), the primary focus is on Langerhans cell histiocytosis. (medscape.com)
  • The Memorial Sloan Kettering Make-an-IMPACT Initiative is a rare-cancer global outreach initiative that provides free genomic profiling for patients with Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Rosai-Dorfman Disease (RDD), Juvenile Xanthogranuloma (JXG), and Histiocytic Sarcoma (HS). (histio.org)
  • Unfortunately, they have a short life expectancy and are more likely to develop cancers such as mast cell tumors and malignant histiocytosis (histiocytic sarcomas). (vmsg.com)
  • Interdigitating dendritic cell sarcoma subtotally replacing lymph node shows that the neoplasm tends to spare lymphoid follicles. (basicmedicalkey.com)
  • Interdigitating dendritic cell sarcoma involving lymph node shows that the neoplastic cells are spindled and epithelioid with abundant eosinophilic cytoplasm. (basicmedicalkey.com)
  • reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
  • Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
  • Histiocytic sarcoma is a tumor derived from histiocytes. (wikipedia.org)
  • Over the last several decades, the nomenclature used to describe histiocytic disorders has substantially changed to reflect the wide range of clinical manifestations and the variable clinical severities of some disorders that have the same pathologic findings. (medscape.com)
  • Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
  • Dedicated to promoting scientific research to uncover the causes of histiocytic diseases and ensure early diagnosis, effective treatment and a cure. (histio.org)
  • Impact of dynamic 18F-FDG PET on the early prediction of therapy outcome in patients with high-risk soft-tissue sarcomas after neoadjuvant chemotherapy: a feasibility study. (uni-heidelberg.de)
  • Prediction of chemotherapy outcome in patients with metastatic soft tissue sarcomas based on dynamic FDG PET (dPET) and a multiparameter analysis. (uni-heidelberg.de)
  • PD-L1 (CD274) copy number gain, expression, and immune cell infiltration as candidate predictors for response to immune checkpoint inhibitors in soft-tissue sarcoma. (uni-heidelberg.de)
  • The other patients had an expansion of clones harboring del(8p) carrying additional driver mutations (EP300, MLL2, EIF2A), with one patient developing trans-differentiation into CD19-negative histiocytic sarcoma. (nih.gov)
  • Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma. (uni-heidelberg.de)
  • Histiocytic sarcoma and tumors with dendritic cell differentiation (HDT) are uncommon neoplasms often with an aggressive clinical course that may occur in association with another hematologic malignancy or mediastinal germ cell tumor (secondary HDT, sHDT). (nih.gov)
  • Histiocytic sarcomas may simultaneously occur in other organs such as the spleen, lung, and uterus and are regarded as systemic neoplasms. (nih.gov)
  • Introduction Histiocytic sarcoma is a rare neoplasm with few cases reported in the literature of which some were diagnosed in animals. (medscape.com)
  • Histiocytic sarcoma (HS) is a rare neoplasm showing evidence of histiocytic differentiation. (medscape.com)
  • Histiocytic sarcoma (Kupffer cell sarcoma) is a multicentric neoplasm of mice that frequently involves the liver. (nih.gov)
  • Histiocytic sarcoma is a rare malignant neoplasm that may occur de novo or in the context of a previous hematologic malignancy or mediastinal germ cell tumor. (nih.gov)
  • Histiocytic Sarcoma (HS) is a rare human hematopoietic neoplasm that accounts for less than 1% of hematolymphoid cancers and is usually fatal. (nih.gov)
  • Each time we learn that a Tripawd cat or dog has beaten the pet cancer odds for an especially aggressive cancer like canine histiocytic sarcoma , we love to celebrate by spreading the good news! (tripawds.com)
  • 6. Clinical prognostic factors in canine histiocytic sarcoma. (nih.gov)
  • 11. MR imaging of histiocytic sarcoma of the canine brain. (nih.gov)
  • 18. Immunocytochemical detection of the class A macrophage scavenger receptor CD204 using air-dried cytologic smears of canine histiocytic sarcoma. (nih.gov)
  • PTPN11 mutations in canine and human disseminated histiocytic sarcoma. (academictree.org)
  • Kennedy K, Thomas R, Durrant J, Jiang T, Motsinger-Reif A , Breen M . Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. (academictree.org)
  • Histiocytic Sarcoma is a very aggressive canine cancer that is rare in the overall dog population, but incredibly common in Bernese Mountain dogs. (shipyarn.com)
  • 8. Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. (nih.gov)
  • Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
  • A splenectomy was performed and the splenic tumor was diagnosed as hemophagocytic histiocytic sarcoma, a cancer with very poor prognosis. (fidocure.com)
  • Histiocytic sarcomas which are a serious type of cancer that starts in a particular type of immune cell. (purina.co.uk)
  • 17. Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog. (nih.gov)
  • It can also pick up 77% of lymphomas, 82% of hemangiosarcoma, and 54% of histiocytic sarcomas. (wearethecure.org)
  • In both sexes of Crj:BDF1 mice, drinking water exposure to quinoline increased the incidences of liver histiocytic sarcoma, and in various organs, haemangioma and haemangiosarcoma. (cdc.gov)
  • We lost our beloved Bernese Mountain Dog, Pico, to Histiocytic Sarcoma on Sept 20th 2023. (shipyarn.com)
  • Low and high magnifications of a histiocytic sarcoma with a nodular growth pattern in the liver. (nih.gov)
  • Spontaneous histiocytic sarcomas occur at low frequency in mice. (nih.gov)
  • Nasal cavity sarcoma, nasal esthesioneuroepithelioma, and mediastinal sarcoma were increased in male rats. (cdc.gov)
  • Conclusion Although histiocytic sarcomas in the brain present an unusual location and have a poorer prognosis, we have identified the first primary leptomeningeal histiocytic sarcoma with a disease-free survival greater than 3 years following multidisciplinary treatment with surgery and chemotherapy and radiotherapy. (medscape.com)
  • Here, we performed whole exome sequencing and RNA-sequencing (RNA-Seq) on 21 archival cases of primary histiocytic sarcoma. (nih.gov)
  • 12. Disseminated histiocytic sarcoma with peripheral blood involvement in a Bernese Mountain dog. (nih.gov)
  • We present the first case of a patient with histiocytic sarcoma that involved the meninges and had a good course after multidisciplinary treatment. (medscape.com)
  • The standard treatment for these sarcomas is surgery. (medscape.com)
  • 3. Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven Bernese mountain dogs with histiocytic sarcoma. (nih.gov)
  • 7. Investigation of a screening programme and the possible identification of biomarkers for early disseminated histiocytic sarcoma in Bernese Mountain dogs. (nih.gov)
  • 10. Monocyte chemotactic protein-1 and other inflammatory parameters in Bernese Mountain dogs with disseminated histiocytic sarcoma. (nih.gov)
  • 14. Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. (nih.gov)
  • Histiocytic Sarcoma Arising From a Long Bone: Report of Two Cases. (rochester.edu)