Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions. (1/58)
To distinguish between transduced cell clearance and transgene regulation following adenoviral gene transfer, we infected F344 rat hepatocytes with an E-1-deleted adenovirus (Ad beta gal) and studied cell survival in the liver of dipeptidyl peptidase IV-deficient (DPPIV-) F344 rats. Transplanted cells were localized with histochemical staining for DPPIV and transgene expression localized with staining for beta-galactosidase (lacZ). The transgene was expressed in 90-100% hepatocytes without impairment in cell viability in vitro, although transplanted cells were cleared mostly within 1 day by infiltrates containing activated macrophages, CD4+ or CD8+ lymphocytes, and phagocytes. When Ad beta gal-transduced hepatocytes were transplanted repeatedly at 14-day intervals, transplanted cells were cleared rapidly each time. LacZ expression following Ad beta gal administration to intact animals was associated with apoptosis and unscheduled DNA synthesis in the liver. To determine whether adenoviral antigen expression activated consequential MHC-restricted liver injury, we transplanted Ad beta gal-hepatocytes followed subsequently by transplantation of nontransduced hepatocytes. Transplanted cells expressing Ad beta gal were rapidly cleared as before, whereas nontransduced hepatocytes engrafted with progressive liver repopulation. The findings indicated that adenovirally transduced cells are cleared early in the host liver. Use of ex vivo strategies will facilitate analysis of modified adenoviral vectors in the context of immunoregulatory, cellular and viral mechanisms. (+info)Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions. (2/58)
Neonatal injection of semiallogeneic spleen cells in BALB/c mice induces a self-limited state of chimerism that promotes the differentiation of donor-specific CD4 T cells toward the Th2 phenotype. Here we show that injection of spleen cells from beta2-microglobulin-deficient (BALB/c x C57BL/6) F1 mice into BALB/c newborns with a disrupted beta2-microglobulin (beta2m) gene results in a lethal lymphoproliferative disorder associated with uncontrolled Th2 response, long-term persistence of donor B cells, and sustained blood eosinophilia. Autoimmune manifestations are also enhanced and characterized by a severe autoantibody-mediated glomerulonephritis. Histological examination of the spleen shows a hyperplasia of periarteriolar lymphoid sheaths, with accumulation of eosinophils and basophils, and variable degree of fibrosis. Perivascular lymphoid infiltrates with eosinophils are also found in the lung and are correlated with disease severity. Such abnormalities are almost absent using beta2m-sufficient mice. These data demonstrate that induction of lymphoid chimerism in the absence of MHC class I-T-cell interactions results in a lethal form of host-versus-graft disease that represents a unique model of Th2-dependent chronic inflammatory disease associated with an hypereosinophilic syndrome in mice. (+info)Allogeneic reconstitution after nonmyeloablative conditioning: mitigation of graft-versus-host and host-versus-graft reactivity by anti-CD44v6. (3/58)
T-cell maturation is accelerated in transgenic mice expressing rat CD44v4-v7 on T cells, the effect being blocked by anti-CD44v6. This finding suggested functional activity of CD44v6 in thymocyte development. We tested the hypothesis by antibody blocking and using mice with targeted deletion of CD44v6/v7 exon products (CD44v6/v7(-/-)). When lethally irradiated CD44v6/v7-competent (CD44v6/v7(+/+)) mice were reconstituted syngeneically, higher numbers of CD44v6/v7(-/-) than CD44v6/v7(+/+) BMC were required for survival, the period of reconstitution was prolonged, and regain of immunocompetence was delayed. Similar findings were observed in lethally irradiated, anti-CD44v6-treated syngeneic CD44v6/v7(+/+) hosts. Thus, CD44v6/v7 supports maturation and expansion of hematopoietic progenitor cells. Surprisingly, reconstitution with CD44v6/v7(-/-) BMC or anti-CD44v6 treatment of the nonlethally irradiated allogeneic CD44v6/v7(+/+) host had only a minor impact on survival rates. When nonlethally irradiated CD44v6/v7(-/-) hosts received an allogeneic graft, survival rates were improved. These phenomena have been a result of reduced GvH reactivities when the donor was CD44v6/v7(-/-) and reduced HvG reactivities in the CD44v6/v7(-/-) host. Thus, although a deficit or blockade of CD44v6/v7 has a negative impact on hematopoietic reconstitution, a transient blockade will be of benefit for the allogeneically reconstituted host because of a strong reduction in GvH and HvG reactivities. (+info)Future of monoclonal antibodies in the treatment of hematologic malignancies. (4/58)
BACKGROUND: The approval of monoclonal antibodies (MAbs) as antibody-targeted therapy in the management of patients with hematologic malignancies has led to new treatment options for this group of patients. The ability to target antibodies to novel functional receptors can increase their therapeutic efficacy. METHODS: The authors reviewed improvements in MAb design to enhance their effectiveness over the existing therapeutic MAb currently approved for treating hematologic malignancies. RESULTS: Three classes of therapeutic MAbs showing promise in human clinical trials for treatment of hematologic malignancies include unconjugated MAb, drug conjugates in which the antibody preferentially delivers a potent cytotoxic drug to the tumor, and radioactive immunotherapy in which the antibody delivers a sterilizing dose of radiation to the tumor. CONCLUSIONS: A better appreciation of how MAbs are metabolized in the body and localized to tumors is resulting in the development of new antibody constructs with improved biodistribution profiles. (+info)Donor T cell and host NK depletion improve the therapeutic efficacy of allogeneic bone marrow cell reconstitution in the nonmyeloablatively conditioned tumor-bearing host. (5/58)
Allogeneic bone marrow cell reconstitution of the nonmyeloablatively conditioned host has the advantage that it can be tolerated in suboptimal health conditions. However, the problem of graft versus host disease (GvHD) remains. Also, graft acceptance may become delicate, and HvGD may arise. We report here on advantages/disadvantages of host natural killer (NK) depletion and graft T cell depletion in fully allogeneic, healthy and solid tumor-bearing mice. NK depletion of the "healthy" host improved the survival rate, whereas graft T cell depletion was disadvantageous. In the tumor-bearing host, graft T cell depletion was beneficial when the host was NK-depleted. Host NK depletion facilitated B lymphopoiesis, repopulation of the thymus, expansion of donor cells, and tolerance induction. The disadvantage of graft T cell depletion in the "healthy" host was a result of delayed engraftment. Because in tumor-bearing mice, host but not graft hematopoiesis was strongly impaired, donor hematopoiesis dominated. Graft T cell depletion reduced GvHD but hardly interfered with engraftment. Importantly, graft-mediated tumor reactivity appeared late and was unimpaired when the graft was T cell-depleted. Thus, concomitant depletion of host NK and donor T cells is advantageous when approaching therapeutic treatment of solid tumors by allogeneic reconstitution of the nonmyeloablatively conditioned host. (+info)Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. (6/58)
OBJECTIVE: To determine the activation status of two cytoplasmic signaling pathways, phosphatidylinositol 3-kinase (PI 3-kinase) and the mitogen-activated protein kinase (MAPK) family. METHODS: We studied the pathogenic CD4+ T cells that drive disease in the parent-into-F(1) mouse model of lupus-like chronic graft-versus-host disease (GVHD). We determined immunoprecipitated kinase activity for PI 3-kinase and MAPK members (Raf-1, extracellular signal-regulated kinase 1 [ERK-1], c-Jun N-terminal kinase 1 [JNK-1], and p38 MAPK) from either unfractionated splenocytes or purified donor CD4+ T cells. Uninjected normal mice served as negative controls, and acute GVHD mice served as positive controls. RESULTS: Compared with negative controls, unfractionated splenocyte kinase activity from chronic GVHD mice was significantly increased for PI 3-kinase and JNK-1, but not for Raf-1, p38 MAPK, or ERK-1. Increased PI 3-kinase and JNK-1 activity was also seen in acute GVHD splenocytes, as was increased Raf-1 and p38 MAPK activity. The pattern of increased PI 3-kinase and JNK-1 activity seen in unfractionated chronic GVHD splenocytes was also seen in isolated donor, but not host, CD4+ T cells from chronic GVHD mice, indicating that donor CD4+ T cell signaling activity accounted for at least a portion of the activity observed in unfractionated splenocytes. Increased ERK-1 activity was not seen in either donor or host CD4+ T cells. This pattern of cytoplasmic signaling pathway in donor CD4+ T cells was associated with increased T cell receptor membrane signaling activation (Lck and Fyn phosphorylation) and increased transcription activation (phosphorylation of inhibitor of nuclear factor kappaB), confirming the biologic significance of these observations. CONCLUSION: The pathogenic T cells driving disease in this murine model exhibit activation in the form of spontaneous cytoplasmic signaling pathway activity that can be detected without in vitro restimulation and involves a T cell-specific (PI 3-kinase) and a nonspecific stress/cytokine pathway (JNK-1). These results raise the possibility that a full characterization of the signaling pathways active in pathogenic lupus T cells might lead to new therapeutic targets. (+info)Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma. (7/58)
Some patients lose chimerism following nonmyeloablative hematopoietic cell transplantation (HCT), yet, surprisingly, enjoy sustained tumor remissions. We hypothesized that host-versus-graft (HVG) alloresponses might induce antitumor effects against recipient tumors. We explored this question in mice by administering recipient leukocyte infusions (RLIs) to mixed chimeras established with nonmyeloablative conditioning. Mixed chimeras were prepared in the B10.A (H2a)-->B6 (H2b) strain combination using depleting anti-T-cell monoclonal antibodies (mAbs), cyclophosphamide, and thymic irradiation. B6 myeloid leukemia cells (MMB3.19) were administered 7 days following donor lymphocyte infusion (DLI) or RLI on day 35. Conversion to full donor chimerism occurred without graft-versus-host disease (GVHD) following DLI, whereas RLI led to loss of chimerism. Both RLI and DLI significantly delayed tumor mortality. In another strain combination (B10.BR [H2k]-->BALB/c [H2d]), RLI-induced or spontaneous loss of chimerism was associated with antitumor effects against the host-type B-cell lymphoma A20. HCT was essential for the antitumor effect of RLI. RLI induced elevated serum interferon-gamma (IFN-gamma) levels, and recipient-derived IFN-gamma was critical for their antitumor effects. Thus, HVG reactions (spontaneous or induced by RLI) mediate antitumor effects against hematologic malignancies via a recipient-derived IFN-gamma-mediated mechanism. A novel approach to achieving anti-tumor effects without the risk of GVHD is suggested. (+info)Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat. (8/58)
The present study was designed to determine whether .N = O produced in vivo during the rejection of histoincompatible tissues might permit serum NO2-/NO3- levels to serve as markers of a rejection reaction. Rat syngeneic and allogeneic liver, heart, bone marrow/spleen cell, small bowel, skin, and sponge matrix grafts were performed and the stable end-products of .N = O, NO2-/NO3-, were serially assayed in the serum of the grafted animals. A significant rise of serum NO2-/NO3- levels in the allografted animals preceded the onset of clinical signs of rejection or graft-versus-host disease, with the exception of the skin and sponge matrix graft models, where elevated serum NO2-/NO3- levels were never observed. In all transplant models, normal serum NO2-/NO3- levels were observed at all times in animals that received syngeneic grafts. Furthermore, treatment of allograft recipients with the immunosuppressive agents FK 506 or cyclosporine A inhibited .N = O production. Determination of serum creatinine levels demonstrated that the elevated serum NO2-/NO3- levels were not caused by kidney dysfunction. Serum NO2-/NO3- levels might be useful early serum markers of the initiation of a rejection reaction or graft-versus-host disease when functional markers of graft dysfunction are not apparent. (+info)'Host versus graft reaction' is an immune response mounted by the recipient's immune system against transplanted tissue or organ, leading to destruction or rejection of the graft.
A Host vs Graft Reaction, also known as graft-versus-host disease (GVHD), is a condition that can occur after a transplant of immunocompetent tissue (like bone marrow or peripheral blood stem cells) from a donor (graft) to a recipient (host). It occurs when the transplanted immune cells recognize the recipient's tissues as foreign and mount an immune response against them. This reaction can cause inflammation and damage to various organs, including the skin, liver, and gastrointestinal tract.
GVHD can be acute or chronic, depending on the time of onset and the severity of symptoms. Acute GVHD typically occurs within 100 days of transplantation and is characterized by a rash, diarrhea, and liver dysfunction. Chronic GVHD, which can occur after day 100, is often more severe and can affect multiple organs, leading to fibrosis and organ dysfunction.
Preventing and managing GVHD is an important consideration in transplant medicine, as it can significantly impact the success of the transplant and the recipient's quality of life. Strategies for preventing and treating GVHD include immunosuppressive therapy, T-cell depletion of the graft, and careful matching of donor and recipient to minimize histocompatibility differences.
U.S. FDA Grants Full Approval of REZUROCK(TM) (belumosudil) for the Treatment of Patients with Chronic Graft-Versus-Host...
Kadmon to Host Conference Call on Monday, July 19, 2021 at 8:00 a. ET -NEW YORK, NY / ACCESSWIRE / July 16, 2021/ Kadmon ... Adverse Reactions. The most common (≥20%) adverse reactions, including laboratory abnormalities, in patients receiving REZUROCK ... U.S. FDA Grants Full Approval of REZUROCK(TM) (belumosudil) for the Treatment of Patients with Chronic Graft-Versus-Host ... In cGVHD, transplanted immune cells (graft) attack the patients cells (host), leading to inflammation and fibrosis in multiple ...
Graft-versus-host disease - Wikipedia
Billingham RE (1966). "The biology of graft-versus-host reactions". Harvey Lectures. 62 (62): 21-78. PMID 4875305. Yasuda H, ... Hale G, Waldmann H (May 1994). "Control of graft-versus-host disease and graft rejection by T cell depletion of donor and ... A wide range of host antigens can initiate graft-versus-host disease, among them the human leukocyte antigens (HLA). However, ... Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the ...
Graft-versus-host disease - Wikipedia
Billingham RE (1966). "The biology of graft-versus-host reactions". Harvey Lectures. 62 (62): 21-78. PMID 4875305.. ... Hale G, Waldmann H (May 1994). "Control of graft-versus-host disease and graft rejection by T cell depletion of donor and ... A wide range of host antigens can initiate graft-versus-host disease, among them the human leukocyte antigens (HLA).[20] ... Polsdorfer, JR Gale Encyclopedia of Medicine: Graft-vs.-host disease. External links[edit]. .mw-parser-output .navbox{box- ...
Leydig cell injury as a consequence of an acute graft-versus-host reaction. - Department of Paediatrics
... in unconditioned F1 mice following the infiltration of donor alloreactive T cells during an acute graft-versus-host reaction ( ... but lower sperm counts in humans also appear to be associated with graft-versus-host disease (GVHD) following allogeneic HSCT. ... Leydig cell injury as a consequence of an acute graft-versus-host reaction. ... Leydig cell injury as a consequence of an acute graft-versus-host reaction. ...
"Acute graft-versus-host reaction in the pancreas." by T A. Seemayer, J G. Gartner et al.
Pediatric Graft Versus Host Disease: Background, Pathophysiology, Epidemiology
... otherwise known as graft versus host disease (GVHD), is a phenomenon that has been described as the age of bone marrow and ... The occurrence of an immunologically mediated and injurious set of reactions by cells genetically disparate to their host, ... Graft-versus-host reaction occurs when donor immune cells recognize disparate host antigens. These differences are governed by ... encoded search term (Pediatric Graft Versus Host Disease) and Pediatric Graft Versus Host Disease What to Read Next on Medscape ...
Biological effects of cyclosporin A: a new antilymphocytic agent
Allogeneic Transplant | Conditions & Treatments | UCSF Health
Plus it
... we have shown host axon regeneration into the graft, synapse formation between sensory axons and graft neurons, graft axon ... NRP/GRP filled the lesion as shown by the dark reaction product of AP histology (A, B), but in response to the BDNF gradient (D ... Another example demonstrates that synaptic boutons from both host and graft can connect with a graft dendrite (*, B). The ... 8B) is contacted by an AP− host axon (Fig. 8B, labeled E) and an AP+ graft axon (Fig. 8B, labeled F). High magnification of the ...
Cutaneous Conditions in Febrile Patients
Connie Rong Shi, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Neupogen 30 MU (0.3 mg/ml) solution for injection - Summary of Product Characteristics (SmPC) - (emc)
Graft versus host diseaseb. Anaphylactic reaction. Metabolism and nutrition disorders Decreased appetitee ... There have been reports of graft versus host disease (GvHD) and fatalities in patients receiving G-CSF after allogeneic bone ... b. Tabulated summary of adverse reactions. The data in the table below describe adverse reactions reported from clinical trials ... Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is ...
DailyMed - POTELIGEO- mogamulizumab-kpkc injection
Complications of Allogeneic HSCT after POTELIGEO: Monitor for severe acute graft-versus-host disease (GVHD) and steroid- ... ADVERSE REACTIONS The most common adverse reactions (reported in ≥20% of patients) are rash, infusion related reactions, ... Table 1: Common Adverse Reactions (≥10%) with ≥2% Higher Incidence in the POTELIGEO Arm Adverse Reactions by Body System *, †. ... 6 ADVERSE REACTIONS The following serious adverse reactions are discussed in greater detail in other sections of the labeling: ...
Fludara (Fludarabine): Uses, Dosage, Side Effects, Interactions, Warning
Transfusion Associated Graft-Versus-Host Disease. Transfusion-associated graft-versus-host disease has been observed after ... Autoimmune Reactions. Instances of life-threatening and sometimes fatal autoimmune phenomena such as hemolytic anemia, ... Therefore, to minimize the risk of transfusionassociated graft-versus-host disease, patients who require blood transfusion and ... Adverse events and those reactions which are more clearly related to the drug are arranged below according to body system. ...
Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT ... K. G. Lerner, G. F. Kao, R. Storb, C. D. Buckner, R. A. Clift, and E. D. Thomas, "Histopathology of graft vs. host reaction ( ... R. E. Billingham, "The biology of graft-versus-host reactions," Harvey Lectures, vol. 62, pp. 21-78, 1966. ... "Role of bacterial microflora in development of intestinal lesions from graft-versus-host reaction," JNCI: Journal of the ...
Recovering from Pediatric BMT - Bone Marrow/Stem Cell Transplant | UCLA Health
Graft-versus-host disease (GVHD): The newly transplanted stem cells are replacing your childs immune system. Sometimes, that ... Your childs doctors will watch for any early signs and prescribe medications to control the reaction if it occurs. ... This event is called graft failure. If graft failure occurs, your childs doctors will discuss possible next steps and ...
Biphasic Calcium Sulfate as an Alternative Grafting Material in Various Dental Applications | Journal of Oral Implantology
Thus, the defect space is maintained while the host vascularizes the grafted area and de novo bone replaces the graft material ... Adverse reactions or failures to heal have not been reported. Bioresorption studies of calcium sulfate and clinical experience ... The flap is repositioned directly on the graft with tension by stretching it for maximal closure over the graft (3 mm of graft ... Various osseous graft materials are available today for dental applications. Included are those from human host origin ( ...
Severe combined immunodeficiency (SCID) | Immune Deficiency Foundation
This reaction is called graft-versus-host disease (GVHD) due to maternal T cell engraftment. ... Graft/transplant rejection: Your childs immune system, even if it doesnt work very well, might notice the new stem cells as ... Antibody-based drugs: Antibody-based drugs use antibodies to target the childs immune cells to decrease risk of graft ...
Mycobacterium chelonae Skin Infection in Kidney-Pancreas Recipient - Volume 11, Number 2-February 2005 - Emerging Infectious...
Because of chronic rejection, the patient lost the kidney graft 5 years later, in 1995, and went back on dialysis with a well- ... In the immunocompromised host, an uncontrolled proliferation of primarily colonizing or contaminating pathogens or commensals ... chelonae was identified by polymerase chain reaction. Therefore, antimicrobial therapy was changed to clarithromycin (500 mg ... M. chelonae infections in an immunocompromised host are disseminated in ,50% of those infected; chronic use of steroids, even ...
condition
The very small number of TEN cases not caused by medicines are often from infections, vaccines, or graft-versus-host disease. ... Its most often caused by a medicine reaction. The very small number of cases not caused by medicines are often due to ... This disorder is most often caused by a medicine reaction. These are often sulfa medicines, as well as other antibiotics or ...
Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged ≥19 Years: Recommendations of the Advisory Committee on...
Limited data for outcomes deemed important by the work group (e.g., possible graft rejection, graft-versus-host-disease, immune ... Grade 3 reactions are defined as reactions related to vaccination severe enough to prevent normal activities. ... graft-versus-host-disease, graft rejection, and reactogenicity) associated with RZV.††. Prevention of herpes zoster and ... reported on graft-versus-host-disease among hematopoietic cell transplant recipients and did not identify an increased risk ...
Foscarnet and Encephalitis Cytomegalovirus - Suspected Cause - Reports of Side Effects
Reactions: Encephalitis Cytomegalovirus, Graft Versus Host Disease, Central Nervous System Lesion, Panencephalitis, CNS ... Reactions: Encephalitis Cytomegalovirus Adverse event resulted in: death Drug(s) suspected as cause:. Foscarnet Dosage: ... Reactions: Encephalitis Cytomegalovirus Adverse event resulted in: death Drug(s) suspected as cause:. Foscarnet Indication: ... Reactions: Encephalitis Cytomegalovirus, Nephropathy Toxic, Retinitis Adverse event resulted in: death Drug(s) suspected as ...
Allogeneic Stimulation of Anti-Hapten Response in Mice | International Archives of Allergy and Applied Immunology | Karger...
When challenged on the same day with NNP.Fγ G, the two groups of mice undergoing a graft-versus-host reaction (GVHR) showed ... Relative Abilities of Parental Thymus and Spleen Cells to Induce Graft-Versus-Host Reactions and Enhance Antibody Formation in ... The antibody-forming cells were of host origin, and the effect could be induced by T lymphocytes, not by B. When mice were ... and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package ...
Amphotericin B - Reports of Side Effects
Reactions: Renal Impairment, Drug Ineffective, Acute Graft Versus Host Disease, Acute Graft Versus Host Disease in Skin Drug(s ... Reactions: Anaphylactic Reaction Adverse event resulted in: hospitalization Drug(s) suspected as cause:. Ceftazidime Dosage: iv ... Indication: Prophylaxis Against Graft Versus Host Disease Levofloxacin Indication: Antibiotic Prophylaxis Voriconazole ... Indication: Prophylaxis Against Graft Versus Host Disease Defarasirox Indication: Zygomycosis Fluconazole Indication: ...
Allogeneic hematopoietic stem cells: work highlights the major changes in the human metabolome in the graft against the host
... work highlights the major changes in the human metabolome in the graft against the host ... the activation and differentiation of immune cells and could therefore contribute to limiting the risk of immune reaction to ... Metabolomics analysis of human acute Graft-versus-Host Disease reveals changes in host and microbiota-derived metabolites, ... Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage ...
RBCs (red blood cells) dosing, indications, interactions, adverse effects, and more.
Septic Reactions. Transfusion Related Acute Lung Injury (TRALI). Circulatory Overload. Transfusion Associated Graft Versus Host ... If a transfusion reaction is suspected, the transfusion should be stopped, the patient assessed and stabilized, the blood bank ... Patients should be monitored for signs of a transfusion reaction including vitals pre, during, and post transfusion. ... notified, and a transfusion reaction investigation initiated. Massive or rapid transfusion may lead to arrhythmias, hypothermia ...
Treatment of Therapy-resistant Chronic Leukemia Using Stem Cells
Underlying conditions: What are they, and why certain people are more vulnerable to Covid-19 | CNN
Pneumococcal Vaccine for Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices, United...
... the influence of graft versus host reaction. Support Care Cancer 1993;1:195-9. https://doi.org/10.1007/BF00366446 PMID:8193881 ... For patients with chronic graft versus host disease (GVHD) who are receiving PCV15, a fourth dose of PCV15 can be administered ... Abbreviations: ACIP = Advisory Committee on Immunization Practices; GVHD = graft versus host disease; HSCT = hematopoietic stem ... especially those with chronic graft versus host disease (GVHD) (185,186). Because of the prolonged process of lymphocyte ...
GvHDAcuteDiseaseAllogeneicPatientsNeuronsGvHRSevereChronicLesionLife-threatenGuided bone regenerVersus host reactionTransfusion reactionsAlloplastsPancreasBoneCyclophosphamideTransplantImmunologicalCellsFebrile nonhemolyticMiceOccursChemotherapyWarnings and PrecautionsAdverse reactionVivo2021ImmunosuppressionCutaneousSkinVaccinesRecipientMechanismsTherapeuticPlateletPatientDepend
GvHD17
- Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. (wikipedia.org)
- GvHD can also occur after a blood transfusion, known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
- This deficit has been mainly attributed to pretransplantation conditioning, but lower sperm counts in humans also appear to be associated with graft-versus-host disease (GVHD) following allogeneic HSCT. (ox.ac.uk)
- Monitor for severe acute graft-versus-host disease (GVHD) and steroid-refractory GVHD. (nih.gov)
- Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
- Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
- Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
- A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. (pasteur.fr)
- Graft against the host (GVHD) is a major complication that may occur after a allograft, and is characterized by tissue damage induced by donor immune cells which react against those of the recipient. (pasteur.fr)
- Indoles derivatives are ligands of the receptor Aryl Hydrocarbon (AhR), which regulates the activation and differentiation of immune cells and could therefore contribute to limiting the risk of immune reaction to allogeneic origin of GVHD. (pasteur.fr)
- These results published in the journal Nature Communications highlight the major changes in the human metabolome after allograft, associated with alterations of the patient's metabolism or its microbiota, which may represent potential therapeutic targets new for the prevention or treating the graft against the host (GVHD). (pasteur.fr)
- A new Phase 3 clinical trial at Winship is enrolling participants after extremely encouraging results in the study's first two phases indicate the first-in-class high-precision cell therapy retains the benefits of stem cell transplant without such serious complications as graft versus host disease (GvHD) and disease relapse in patients with certain blood cancers. (emory.edu)
- GvHD is an immune reaction of donor T cells against normal tissues in the transplant recipient," he says. (emory.edu)
- These cells expand and help prevent both rejection of the graft and GvHD. (emory.edu)
- Learn how graft-versus-host disease (GVHD) can affect the skin, hair, and nail, and treatment options available to relieve symptoms. (bmtinfonet.org)
- Graft-versus-host disease (GVHD) is a common complication after a stem cell transplant with donor cells (allogeneic transplant). (bmtinfonet.org)
- It's a pleasure to speak with all of you today about graft-versus-host disease (GVHD) of, the skin, hair, and nails. (bmtinfonet.org)
Acute8
- In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
- In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (wikipedia.org)
- Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
- Leydig cell injury as a consequence of an acute graft-versus-host reaction. (ox.ac.uk)
- Here we demonstrate that injury to intratesticular cells occurs in unconditioned F1 mice following the infiltration of donor alloreactive T cells during an acute graft-versus-host reaction (GVHR). (ox.ac.uk)
- Acute graft-versus-host reaction in the pancreas. (jax.org)
- Acute hemolytic transfusion reactions (AHTR) are most commonly the result of antibodies in the recipient's plasma that aredirected against antigens on the donor RBCs. (medscape.com)
- The improved transplantation efficiency in the delay condition could be explained by the fact that the acute inflammatory reaction that occurs after injury decreases within a few days following the insult, thus leading to an environment more receptive for grafting. (jneurosci.org)
Disease24
- NEW YORK, NY / ACCESSWIRE / July 16, 2021 / Kadmon Holdings, Inc. (Nasdaq:KDMN) today announced that the U.S. Food and Drug Administration (FDA) has approved REZUROCK ™ (belumosudil) 200 mg once daily (QD) for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy. (yahoo.com)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (wikipedia.org)
- Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands. (wikipedia.org)
- The chronic form of graft-versus-host disease (cGvHD) normally begins 90 to 600 days post-transplant. (wikipedia.org)
- Not to be confused with Host-versus-graft disease . (wikipedia.org)
- Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
- Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cycloporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. (nih.gov)
- To compensate for the various disadvantages mentioned for these graft types, some synthetic graft materials (alloplasts) offer a fully resorbable state and have no related disease transmission potential. (allenpress.com)
- The very small number of TEN cases not caused by medicines are often from infections, vaccines, or graft-versus-host disease. (massgeneral.org)
- The very small number of cases not caused by medicines are often due to infections, vaccinations, or graft-versus-host disease. (massgeneral.org)
- To guide its deliberations, ACIP used the Evidence to Recommendations Framework and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach ( 8 ) to evaluate possible benefits (prevention of herpes zoster, postherpetic neuralgia, and herpes zoster-related hospitalizations) and harms (serious adverse events [SAEs],** immune-mediated disease, graft-versus-host-disease, graft rejection, and reactogenicity) associated with RZV. (cdc.gov)
- In immunocompetent hosts, nontuberculous mycobacteria can colonize body surfaces and be secreted for prolonged periods without causing disease. (cdc.gov)
- In the immunocompromised host, an uncontrolled proliferation of primarily colonizing or contaminating pathogens or commensals can progress to severe disease. (cdc.gov)
- When a person undergoes a bone marrow transplant using stem cells from a donor, or they receive an organ, a doctor may prescribe medications to prevent graft-versus-host disease and mitigate the immune system's reaction by suppressing its function. (cnn.com)
- Principal investigator Edmund K. Waller, MD, PhD, FACP, says the net result of giving the patient a precise number of donor T cells with specific functions "leads to better elimination of cancer with less graft versus host disease and less toxicity from the transplant. (emory.edu)
- Graft versus host disease can cause severe damage to the skin, liver, intestines and lungs," Waller says. (emory.edu)
- Similar to approved unmanipulated cord blood products, the prescribing information contains a Boxed Warning for fatal or life-threatening infusion reactions, graft versus host disease, engraftment syndrome and graft failure. (fda.gov)
- You should also notify your provider if you have had or plan on having an allogeneic stem cell transplant as this medication can worsen a side effect of the transplant called graft-versus-host disease. (oncolink.org)
- My name is Marla O'Keefe and I will be your moderator for this workshop, Graft-versus-Host Disease: Skin, Hair, and Nails. (bmtinfonet.org)
- Her outpatient clinical practice is devoted to caring for people affected by graft-versus-host disease. (bmtinfonet.org)
- Its label bears a boxed warning for infusion reactions, graft-versus-host disease, engraftment syndrome and graft failure, all of which may be fatal. (pharmalive.com)
- Concerns exist, however, with the use of both autogenous grafts due to the need to harvest the osteochondral implants from a joint or part of a joint that is otherwise healthy, and for allogeneic materials with respect to disease transmission. (biomedcentral.com)
- Leukoreduced RBCs still contain enough leukocytes capable of producing transfusion-associated graft versus host disease (TAGVHD) in susceptible patients. (utmb.edu)
- reasonable with the dose of PPSV23 being replaced by a dose of PCV13 in the context of graft-versus-host disease. (cdc.gov)
Allogeneic3
- Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response and the development of a graft versus leukemia effect. (emory.edu)
- One means of treating osteoarthritis is with autologous or allogeneic osteochondral grafts. (biomedcentral.com)
- There is the potential for using photooxidized xenogeneic osteochondral scaffolds in place of autogenous or allogeneic grafts. (biomedcentral.com)
Patients8
- In contrast to FNHR, primary urticarial reactions can be prevented with antihistamine premedication, so prophylaxis is indicated in patients with a past history of a primary urticarial reaction. (medscape.com)
- The most common adverse reactions (reported in ≥20% of patients) are rash, infusion related reactions, fatigue, diarrhea, musculoskeletal pain, and upper respiratory tract infection ( 6.1 ). (nih.gov)
- In patients with hematologic malignancies in Study P0501, the most common Grade 3-5 adverse reactions were pain, mucosal inflammation, hypertension, and gastrointestinal toxicity. (fda.gov)
- Patients who have experienced bone loss might require a bone graft to help support existing teeth or an upcoming restoration. (colgate.com)
- The graft versus host reaction is rare but is especially dangerous in patients who are immunocompromised. (medscape.com)
- Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients. (who.int)
- La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
- Epidemiologic, immunologic, and virus characteristics in patients with paired SARS-CoV-2 serology and reverse transcription polymerase chain reaction testing. (cdc.gov)
Neurons5
- Here we tested the ability of graft-derived neurons to reestablish connectivity by forming neuronal relays between injured dorsal column (DC) sensory axons and the denervated dorsal column nuclei (DCN). (jneurosci.org)
- Immunoelectron microscopy revealed excitatory synaptic connections between regenerating host axons and graft-derived neurons at C1 as well as between graft axons and DCN neurons in the brainstem. (jneurosci.org)
- Functional analysis by stimulus-evoked c-Fos expression and electrophysiological recording showed that host axons formed active synapses with graft neurons at the injury site with the signal propagating by graft axons to the DCN. (jneurosci.org)
- Graft transplantation of embryonic cortical neurons may thus hold therapeutic potential and warrants further detailed analysis of its translational value. (jneurosci.org)
- sought to identify the optimal time for transplantation by comparing the effect of immediate and delayed transplantation of E14 motor cortical neurons on graft vascularization, survival, and contribution to long-term motor outcome. (jneurosci.org)
GvHR2
- When challenged on the same day with NNP.F γ G, the two groups of mice undergoing a graft-versus-host reaction (GVHR) showed higher numbers of antibody-producing cells to both NNP and F γ G determinants. (karger.com)
- The antibody-forming cells were of host origin, and the effect could be induced by T lymphocytes, not by B. When mice were challenged with NNP.F γ G at various intervals after the induction of GVHR, it was found that by 8 days the increased response was seen only in mice primed to hapten on the heterologous carrier (NNP.OV). (karger.com)
Severe4
- These reactions develop more immediately, with the familiar sequelae of urticaria, angioedema, wheezing, and hypotension in severe cases. (medscape.com)
- Less severe anaphylactoid reactions can also occur when recipients have antibodies to various antigens in the donor blood products. (medscape.com)
- Temporarily interrupt the infusion of POTELIGEO for mild to severe (Grades 1 to 3) infusion reactions and treat symptoms. (nih.gov)
- Unfortunately, two weeks after his stem cell transplant, Hughie developed a severe graft versus host reaction to his transplant. (candlelighters.org.uk)
Chronic2
- Because of chronic rejection, the patient lost the kidney graft 5 years later, in 1995, and went back on dialysis with a well-functioning pancreas graft. (cdc.gov)
- Histology indicated a chronic inflammatory reaction to the photooxidized implant. (biomedcentral.com)
Lesion3
- A mixed population of neuronal and glial restricted precursors (NRP/GRP) derived from the embryonic spinal cord of alkaline phosphatase (AP) transgenic rats were grafted acutely into a DC lesion at C1. (jneurosci.org)
- Within a few weeks, the lesion disappeared completely, and the patient retained good pancreatic graft function. (cdc.gov)
- In a pilot study, transplanting the graft 4, 7, or 30 d after lesion induction indicated that a delay of 7 d was the optimal time for transplantation. (jneurosci.org)
Life-threaten1
- Permanently discontinue POTELIGEO for any life-threatening infusion reaction ( 5.2 ). (nih.gov)
Guided bone regener1
- The use of osseous graft materials and guided bone regeneration have demonstrated enhancement of socket healing by potentially modifying the resorption process. (allenpress.com)
Versus host reaction1
- The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
Transfusion reactions2
- Similarly, emergency physicians must be familiar with and able to manage these adverse transfusion reactions. (medscape.com)
- Non-life-threatening transfusion reactions comprise febrile nonhemolytic reactions (FNHR) and primary urticarial or hypotensive reactions. (medscape.com)
Alloplasts1
- Included are those from human host origin (autografts), human cadaver origin (allografts), other species (equine, porcine, or bovine), and synthetic materials (alloplasts). (allenpress.com)
Pancreas1
- Immune reactions can affect the pituitary, thyroid, pancreas, and adrenal glands, resulting in inflammation of these glands, which can affect their production of certain hormones. (oncolink.org)
Bone23
- For example, if a patient is typing with mixed field reactions fol owing a bone marrow transplant, select the predominant blood type and enter a note in the comments section such as, "Group A recipient of group O bone marrow transplant currently typing as mixed field. (cdc.gov)
- Various grafting materials have been used in oral and periodontal surgeries to augment and rebuild bone intraorally. (allenpress.com)
- Thus, for augmenting large and more complex bone deficiencies Bond Apatite, a composite graft formulation, is indicated. (allenpress.com)
- Literature supports that when performing socket preservations with grafting materials, the crestal bone levels are maintained at a higher level than those where socket grafting was not performed. (allenpress.com)
- However, there may be limited available donor site bone with an inadequate volume for a large defect that needs to be grafted. (allenpress.com)
- 5 This is of concern when placing an implant into the site which has been grafted with a xenograft as there is a decrease in the bone-to-implant contact due to the remaining residual xenograft particles at the implant bone interface. (allenpress.com)
- Fortunately, bone augmentation procedures like bone grafting can help restore the density and volume of your jawbone. (colgate.com)
- Learn more about dental bone grafts and how they can increase the viability of your dental implant. (colgate.com)
- What Is a Dental Bone Graft? (colgate.com)
- A dental bone graft is a procedure that replaces missing bone in your jaw with bone grafting material to encourage regeneration. (colgate.com)
- As the natural bone grows, it absorbs the graft material, resulting in a fully integrated region of new bone. (colgate.com)
- Allografts come from a human donor, usually cadaver bone that has undergone treatments to make it neutral to immune reactions and free of host diseases. (colgate.com)
- According to the Journal of Pharmacy and BioAllied Sciences , practitioners consider autographs the gold standard for bone grafting material but consult with your dental professional to determine the best option for your procedure. (colgate.com)
- Why Do You Need a Dental Bone Graft? (colgate.com)
- If you need a tooth extraction and are considering a dental implant, your dental professional might recommend bone grafting. (colgate.com)
- In fact, it is estimated that half of implant placement procedures require bone grafts. (colgate.com)
- What Are the Steps of a Dental Bone Graft Procedure? (colgate.com)
- Before your dental bone graft procedure, you will meet with a periodontist or oral surgeon to discuss the treatment plan and determine the bone grafting material to be used. (colgate.com)
- Combining tooth extraction with bone grafting encourages faster healing. (colgate.com)
- Then, he or she will attach the bone graft material to the exposed bone. (colgate.com)
- Bone grafting is just one type of bone augmentation procedure, and others may be needed to build bone in your mouth and support dental implants. (colgate.com)
- This surgical procedure divides the jawbone into an inner and outer section to insert bone graft material, create new bone, and widen the jaw to support dental implants. (colgate.com)
- Nationwide tuberculosis outbreak in the USA linked to a bone graft product: an outbreak report. (cdc.gov)
Cyclophosphamide1
- Cyclophosphamide is an anti- Volume 100 of the the graft. (who.int)
Transplant2
- To create the precision-engineered donor graft, Waller explains that different cellular subsets in the graft are selectively purified and then infused into the transplant recipient in a timed fashion. (emory.edu)
- However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
Immunological1
- The purpose of this study was to evaluate the innate immunological response in humans toward xeno-derived osteochondral grafts that have been partially or entirely treated by the photooxidation process. (biomedcentral.com)
Cells4
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
- The conventional T cells help eliminate the cancer in the patient through a process called "graft-versus-leukemia. (emory.edu)
- performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
- Fever may be caused by a reaction to the transfused white blood cells or to chemicals (cytokines) released by the transfused white blood cells. (msdmanuals.com)
Febrile nonhemolytic1
- Most frequently encountered is a febrile nonhemolytic reaction. (medscape.com)
Mice1
- Active suppression of host-vs graft reaction in pregnant mice. (mcmaster.ca)
Occurs1
- After that, a nurse checks on the recipient periodically and must stop the transfusion if an adverse reaction occurs. (msdmanuals.com)
Chemotherapy1
- from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
Warnings and Precautions1
- However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. (karger.com)
Adverse reaction5
- An adverse reaction number wil be auto entered by NHSN. (cdc.gov)
- Indicate the patient's comorbid conditions at the time of the conditions at the time of the transfusion related to the adverse reaction. (cdc.gov)
- NOTE: For more transfusion related to the information about the Patient Medical History question, please refer adverse reaction. (cdc.gov)
- Indicate the International Classification of Diseases (ICD) -10-CM code for the patient's comorbid conditions at the time of the transfusion related to the adverse reaction. (cdc.gov)
- To minimize the chance of an adverse reaction during a transfusion, health care practitioners take several precautions. (msdmanuals.com)
Vivo3
- In vivo imaging using two-photon microscopy further confirmed that vascularization in the delayed condition consisted of both regenerated host vessels and donor blood vessels. (jneurosci.org)
- Estos linfocitos citotóxicos pueden generarse in vitro en cultivos mixtos de linfocitos (MLC, siglas en inglés), in vivo durante una reacción de injerto contra huésped (GVH, siglas en inglés), o después de la inmunización con un aloinjerto, célula tumoral o célula diana modificada químicamente o transformada por virus. (bvsalud.org)
- These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. (bvsalud.org)
20211
- Kadmon to Host Conference Call on Monday, July 19, 2021 at 8:00 a.m. (yahoo.com)
Immunosuppression1
- X-rays or other types of ionizing in much higher dosage, are used to and there is excess risk of B-cel radiation, immunosuppression is maintain the functional and anatom- non-Hodgkin lymphoma (NHL) when most pronounced if the entire body, ical integrity of foreign tissues graft- immunosuppression is accompanied rather than a limited area, is irra- ed onto another individual, such as by continuing immune stimulation diated. (who.int)
Cutaneous1
- If SJS or TEN is suspected, stop POTELIGEO and do not resume unless SJS or TEN has been excluded and the cutaneous reaction has resolved to Grade 1 or less. (nih.gov)
Skin1
- If a medicine is causing the skin reaction, it is stopped. (massgeneral.org)
Vaccines1
- Editorial: Codon Usage and Dinucleotide Composition of Virus Genomes: From the Virus-Host Interaction to the Development of Vaccines. (cdc.gov)
Recipient2
- The reactions occur when the recipient has developed anti-IgA antibodies from previous exposure to donor IgA. (medscape.com)
- Because most adverse reactions occur during the first 15 minutes of the transfusion, the recipient is closely observed at first. (msdmanuals.com)
Mechanisms2
- The exact mechanisms behind these reactions have not been entirely elucidated. (medscape.com)
- It would be valuable for future studies to investigate the molecular mechanisms underlying the enhanced graft survival rate after delayed transplantation. (jneurosci.org)
Therapeutic1
- This phase might provide an optimal therapeutic window for transplantation because it may increase functional integration of the graft into the host tissue. (jneurosci.org)
Platelet2
- These reactions develop most often with platelet transfusions, and are also more frequently observed with larger-volume transfusions. (medscape.com)
- Delayed reaction after a platelet transfusion, i.e. not immediate, but within a few hours, must raise the suspicion of an infected product, requiring immediate blood cultures, broad spectrum antibiotics. (brainkart.com)
Patient1
- If a transfusion reaction is suspected, the transfusion should be stopped, the patient assessed and stabilized, the blood bank notified, and a transfusion reaction investigation initiated. (medscape.com)
Depend1
- Instead, it may depend on the host and donor molecular similarities or distinctions critical for the organogenesis program. (frontiersin.org)