Hypertrichosis
Gingival Hyperplasia
Impact of cyclosporin A pharmacokinetics on the presence of side effects in pediatric renal transplantation. (1/51)
Cyclosporin A (CsA) is a potent immunosuppressant that has many side effects, including hypertrichosis, gingival hyperplasia, and tremor. To evaluate whether there is a relationship between the CsA-pharmacokinetics (PK) and these side effects, their presence and intensity were observed in 46 renal transplanted children/adolescents during two regular visits, and the occurrence of the side effects was correlated with CsA-PK. CsA doses had been unchanged for at least 6 mo. CsA blood concentrations were measured at time 0, and 1, 2, and 4 h after the CsA morning dose. An abbreviated area under the curve (AUC) was calculated using C0, C2, and C4. Hypertrichosis positively correlated with C2, C4, Cmax, and AUC. An AUC > or = 4158 ng/ml per h was the best predictor for the presence of hypertrichosis. Tremor was also positively correlated with C2, Cmax, and AUC. A Cmax > or = 878 ng/ml was the best predictor for the appearance of tremor. These values of Cmax and AUC are within the therapeutic range of CsA as demonstrated by the studies of calcineurin inhibition by CsA. Gingival hyperplasia was not associated with any of the CsA-PK studied parameters. However, it was associated with the concomitant use of nifedipine. These data show that there is a correlation between the CsA side effects and its pharmacokinetics and that it is possible to decrease the incidence and intensity of such side effects by monitoring the CsA-PK parameters, providing they are under or at the proposed cutoff levels. Nifedipine should also be avoided to reduce the presence of gingival hyperplasia. (+info)Treatment with cyclosporin switching to hydroxychloroquine in patients with rheumatoid arthritis. (2/51)
OBJECTIVE: To investigate the therapeutic benefit of cyclosporin A (CSA) switching to hydroxychloroquine (HCQ) in patients with rheumatoid arthritis (RA). METHODS: Thirty four patients with RA who displayed residual inflammation and disability despite partial responses to prior maximal tolerated doses of methotrexate, were included. All were treated with a staged approach using CSA for 24 weeks to induce clinical improvement, followed by HCQ for 16 weeks to maintain the improvement. Seven ACR core set measures were evaluated every four to eight weeks. RESULTS: During a 40 week open trial, 27/34 patients completed the study. CSA treatment significantly reduced the tender joints score, swollen joints score, visual analogue pain scale, patient's or doctor's global assessment, patient's self assessed disability, and C reactive protein. Compared with the time of entry into the trial, patients who switched from CSA to HCQ still possessed significantly lower levels of most variables, determined at 28, 32, and 40 weeks. According to the ACR 20% improvement definition, 15/27 (56%) patients had improved at 24 weeks after CSA treatment, and 14/27 (52%) remained improved at 16 weeks after the change to HCQ. Frequent side effects, such as hypertrichosis, gastrointestinal trouble, and hypertension, were noted during CSA treatment, but most of these disappeared after switching to HCQ. The mean levels of blood pressure and serum creatinine were significantly increased during CSA treatment, but returned to normal after changing to HCQ. CONCLUSIONS: The data suggest that CSA switching to HCQ treatment may be an effective strategy for patients with RA partially responding to methotrexate, particularly those with toxicity due to CSA. (+info)Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. (3/51)
The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal papilla cells. The mechanism of production of vascular endothelial growth factor remains unclear, however. We hypothesize that adenosine serves as a mediator of vascular endothelial growth factor production. Minoxidil-induced increases in levels of intracellular Ca(2+) and vascular endothelial growth factor production in cultured dermal papilla cells were found to be inhibited by 8-sulfophenyl theophylline, a specific antagonist for adenosine receptors, suggesting that dermal papilla cells possess adenosine receptors and sulfonylurea receptors, the latter of which is a well-known target receptor for adenosine-triphosphate-sensitive potassium channel openers. The expression of sulfonylurea receptor 2B and of the adenosine A1, A2A, and A2B receptors was detected in dermal papilla cells by means of reverse transcription polymerase chain reaction analysis. In order to determine which of the adenosine receptor subtypes contribute to minoxidil-induced hair growth, the effects of subtype-specific antagonists for adenosine receptors were investigated. Significant inhibition in increase in intracellular calcium level by minoxidil or adenosine was observed as the result of pretreatment with 8-cyclopentyl-1,3-dipropylxanthine, an antagonist for adenosine A1 receptor, but not by 3,7-dimethyl-1-propargyl-xanthine, an antagonist for adenosine A2 receptor, whereas vascular endothelial growth factor production was blocked by both adenosine A1 and A2 receptor antagonists. These results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosine. (+info)Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. (4/51)
Cell adhesion and communication are interdependent aspects of cell behavior that are critical for morphogenesis and tissue architecture. In the skin, epidermal adhesion is mediated in part by specialized cell-cell junctions known as desmosomes, which are characterized by the presence of desmosomal cadherins, known as desmogleins and desmocollins. We identified a cadherin family member, desmoglein 4, which is expressed in the suprabasal epidermis and hair follicle. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. We also show that DSG4 is an autoantigen in pemphigus vulgaris. Characterization of the phenotype of naturally occurring mutant mice revealed disruption of desmosomal adhesion and perturbations in keratinocyte behavior. We provide evidence that desmoglein 4 is a key mediator of keratinocyte cell adhesion in the hair follicle, where it coordinates the transition from proliferation to differentiation. (+info)Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes. (5/51)
One of the most common side effects of treatment with cyclosporin A (CsA) is hypertrichosis. This study shows that calcineurin activity is associated with hair keratinocyte differentiation in vivo, affecting nuclear factor of activated T cells (NFAT1) activity in these cells. Treatment of nude or C57BL/6 depilated normal mice with CsA inhibited the expression of keratinocyte terminal differentiation markers associated with catagen, along with the inhibition of calcineurin and NFAT1 nuclear translocation. This was associated with induction of hair growth in nude mice and retardation of spontaneous catagen induction in depilated normal mice. Furthermore, calcineurin inhibition blocked the expression of p21(waf/cip1) and p27(kip1), which are usually induced with differentiation. This was also associated with an increase in interleukin-1alpha expression (nude mice), a decrease in transforming growth factor-beta (nude and normal mice), and no change in keratinocyte growth factor expression in the skin. Retardation of catagen in CsA-treated mice was accompanied by significant alterations in apoptosis-related gene product expression in hair follicle keratinocytes. The ratio of the anti-apoptotic Bcl-2 to proapoptotic Bax expression increased, and expression of p53 and interleukin-1beta converting enzyme activity decreased. These data provide the first evidence that calcineurin is functionally active in follicular keratinocytes and that inhibition of the calcineurin-NFAT1 pathway in these cells in vivo by CsA enhances hair growth. (+info)KORSAKOFF'S SYNDROME ASSOCIATED WITH ADRENAL VIRILISM. (6/51)
Korsakoff's syndrome of obscure etiology was observed in a 34-year-old single woman with an 11-year history of hirsutism and mood swings, and previous hospitalizations for mania three years ago and depression 11 years ago.Recently the virilism had intensified with increased muscularity and coarsening of facial features. The 24-hour urinary 17-ketosteroids ranged between 14.4 mg. and 21.5 mg. and were suppressed by dexamethasone. The 17-hydroxycorticosteroid excretion was normal. These and other findings suggested a diagnosis of adrenal virilism due to adrenocortical hyperplasia. In the absence of other discernible causes it appeared that the adrenal pathology was responsible for the Korsakoff's syndrome. Both conditions responded well to glucocorticoid therapy although low doses were necessary to avoid mania.It is speculated that the encephalopathy was due to an associated adrenal insufficiency. Although hypoadrenalism is accepted as a complication of only the infant form of adrenal virilism, it is noteworthy that this patient had pathological pigmentation of her skin. (+info)THE DE LANGE SYNDROME: REPORT OF THREE CASES. (7/51)
Three cases of de Lange's syndrome are described. This condition is characterized by generally severe mental retardation, reduced stature, mild microcephaly, hypertrichosis, various anomalies of hands and feet, and a peculiar facies. The most outstanding features of the latter are the low forehead, profuse, generally confluent eyebrows, abundant long eyelashes, eyes that frequently slant downwards and outwards in antimongoloid fashion, pug nose with prominent anteverted nostrils, increased distance between nose and vermilion border of upper lip, slight reduction in size of chin, and often abnormally low-placed ears. The etiology of de Lange's syndrome is at present unknown. (+info)Acquired eyelash trichomegaly and generalized hypertrichosis associated with breast anomaly. (8/51)
Acquired eyelash trichomegaly is a rare condition. We present a 23-year-old woman with acquired trichomegaly and generalized hypertrichosis from childhood. The patient also exhibited bilateral nipple retraction and unilateral left-sided accessory nipple. According to our knowledge the association between trichomegaly, hypertrichosis, and breast anomaly has not been reported. (+info)Hypertrichosis is a condition characterized by an abnormal growth of hair over the body, either congenital or acquired, affecting both men and women irrespective of their age, race, or ethnicity.
Hypertrichosis is a medical term that refers to an abnormal growth or overabundance of hair in areas where hair is not typically found or excessively thick. It can affect both men and women, and it can be present at birth (congenital) or develop later in life (acquired). The cause of congenital hypertrichosis is usually genetic, while acquired hypertrichosis can be caused by various factors such as medications, hormonal imbalances, metabolic disorders, or cancer.
Hypertrichosis should not be confused with hirsutism, which is a condition that causes excessive hair growth in women in areas where hair is typically found in men, such as the face, chest, and back. Hirsutism is usually caused by hormonal imbalances, while hypertrichosis can occur anywhere on the body.
Hypertrichosis can be localized, affecting only specific areas of the body, or generalized, affecting large portions of the body. Treatment for hypertrichosis depends on the underlying cause and may include medications to slow hair growth, laser therapy, or hair removal methods such as waxing, shaving, or plucking.
Gingival hyperplasia is an abnormal growth or overgrowth of the gingival tissue, which can result from inflammation, certain medications, or genetic factors, and may lead to aesthetic concerns, discomfort, or difficulty in maintaining oral hygiene if left untreated.
Gingival hyperplasia is a condition characterized by an abnormal growth or enlargement of the gingiva (gum tissue). This condition can be caused by various factors, including bacterial infection, certain medications (such as phenytoin, cyclosporine, and nifedipine), systemic diseases (such as leukemia, vitamin C deficiency, and Crohn's disease), and genetic disorders.
The enlarged gum tissue can be uncomfortable, irritated, and prone to bleeding, especially during brushing or flossing. It may also make it difficult to maintain good oral hygiene, which can increase the risk of dental caries and periodontal disease. Treatment for gingival hyperplasia typically involves improving oral hygiene, controlling any underlying causes, and in some cases, surgical removal of the excess tissue.
'Hair removal' is the process or action of removing unwanted hair from the body, which can be achieved through various methods including physical (tweezing, shaving, waxing, threading, epilation), chemical (depilatories), or medical procedures (laser, electrolysis).
Hair removal is the deliberate elimination or reduction of body hair. This can be achieved through various methods, both temporary and permanent. Some common temporary methods include shaving, waxing, tweezing, and depilatory creams. Permanent methods may involve laser hair removal or electrolysis, which target the hair follicle to prevent future growth. It's important to note that some methods can have side effects or risks, so it's recommended to consult with a healthcare professional or dermatologist before starting any new hair removal regimen.
Nucleoside Transport Proteins are membrane-bound proteins responsible for the facilitated diffusion of nucleosides and related deoxynucleosides across the cell membrane, playing a crucial role in regulating intracellular nucleoside concentrations, DNA replication, repair, and other nucleic acid metabolism processes.
Nucleoside transport proteins (NTTs) are membrane-bound proteins responsible for the facilitated diffusion of nucleosides and related deoxynucleosides across the cell membrane. These proteins play a crucial role in the uptake of nucleosides, which serve as precursors for DNA and RNA synthesis, as well as for the salvage of nucleotides in the cell.
There are two main types of NTTs: concentrative (or sodium-dependent) nucleoside transporters (CNTs) and equilibrative (or sodium-independent) nucleoside transporters (ENTs). CNTs mainly facilitate the uptake of nucleosides against a concentration gradient, using the energy derived from the sodium ion gradient. In contrast, ENTs mediate bidirectional transport, allowing for the equalization of intracellular and extracellular nucleoside concentrations.
Nucleoside transport proteins have been identified in various organisms, including humans, and are involved in numerous physiological processes, such as cell proliferation, differentiation, and survival. Dysregulation of NTTs has been implicated in several pathological conditions, including cancer and viral infections, making them potential targets for therapeutic intervention.
Hypertrichosis
Congenital hypertrichosis is always present at birth. Hypertrichosis lanuginosa Congenital hypertrichosis lanuginosa can be ... Nevoid hypertrichosis Nevoid hypertrichosis may be present at birth or appear later in life. It features an isolated area of ... Hypertrichosis is an abnormal amount of hair growth over the body. The two distinct types of hypertrichosis are generalized ... Patterned hypertrichosis Acquired patterned hypertrichosis is an increase in hair growth in a pattern formation. It is similar ...
Prepubertal hypertrichosis
While hypertrichosis affects men and women equally, hypertrichosis of the ears, hypertrichosis of the nose, and hereditary ... hypertrichosis lanuginosa congenita and hypertrichosis congenita terminalis. Syndromic congenital generalized hypertrichosis ... Prepubertal hypertrichosis on its own is a relatively rare condition. Reports of prepubertal hypertrichosis can be attributed ... In generalized hypertrichosis, excessive hair growth occurs all over the body, whereas in localized hypertrichosis, excessive ...
Localized hypertrichosis
... may refer to: Localized acquired hypertrichosis Localized congenital hypertrichosis See also: ... Hypertrichosis This disambiguation page lists articles associated with the title Localized hypertrichosis. If an internal link ...
Nevoid hypertrichosis
... is a cutaneous condition characterized by the growth of terminal hairs in a circumscribed area. ...
Hypertrichosis cubiti
... (also known as "hairy elbow syndrome") is a cutaneous condition characterized by multiple terminal hairs ... One known cause of hypertrichosis cubiti is Wiedemann-Steiner syndrome. Hook nail List of cutaneous conditions Rapini, Ronald P ...
Auricular hypertrichosis
... (hypertrichosis lanuginosa acquisita, hypertrichosis pinnae auris) is a genetic condition expressed as ... hypertrichosis lanuginosa acquisita). The genetic basis of auricular hypertrichosis has not been settled. Some researchers have ... Rao, DC (1972). "Hypertrichosis of the ear rims. Two remarks on the two-gene hypothesis". Acta Genet Med Gemellol (Roma). 21 (3 ... Ear hair Hypertrichosis Mader, Sylvia S. (2000). Human biology. New York: McGraw-Hill. ISBN 978-0-07-290584-7. OCLC 41049448. W ...
X-linked hypertrichosis
... is a hereditary disorders characterized by generalized congenital hypertrichosis and thick eyebrows. X- ... linked congenital generalized hypertrichosis (CGH), is an extremely rare condition that is primarily characterized by universal ... "X-Linked Congenital Hypertrichosis Syndrome Is Associated with Interchromosomal Insertions Mediated by a Human-Specific ...
Gingival fibromatosis with hypertrichosis
... is a cutaneous condition characterized by dark terminal hairs on the peripheral face ...
Hypertrichosis 1 (universalis, congenital)
... is a protein that in humans is encoded by the HTC1 gene. "Human PubMed Reference:". ... "Entrez Gene: Hypertrichosis 1 (universalis, congenital)". Retrieved 2016-06-16. v t e (Articles with short description, Short ...
Hypertrichosis simplex of the scalp
... is a cutaneous condition caused by defects in the corneodesmosin protein. Hairy elbow ...
Amaurosis congenita, cone-rod type, with congenital hypertrichosis
"Orphanet: Amaurosis hypertrichosis syndrome". www.orpha.net. Retrieved 2022-06-13. "OMIM Entry - 204110 - Amaurosis Congenita, ... Amaurosis congenita, cone-rod type, with congenital hypertrichosis is a very rare genetic disorder which is characterized by ... "Amaurosis congenita cone-rod type with congenital hypertrichosis - Rare Hematology News". Retrieved 2022-06-13. Jalili, I. K. ( ... "Amaurosis congenita cone-rod type with congenital hypertrichosis - About the Disease - Genetic and Rare Diseases Information ...
Supernumerary nipples-uropathies-Becker's nevus syndrome
Saleh D, Yarrarapu SN, Cook C (2022). "Hypertrichosis". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30521275 ...
Body hair
Taylor, Sarah K (18 June 2009). "Congenital Hypertrichosis Lanuginosa". Emedicine. Medscape. Retrieved 4 December 2009. ... or a rare genetic disorder known as hypertrichosis. Sometimes it is caused by use of anabolic steroids. Cultural pressure leads ...
Bearded lady
... is a woman with a naturally occurring beard normally due to the condition known as hirsutism or hypertrichosis. Hypertrichosis ... Hamlin, Kimberly A. (2011). "The "Case of a Bearded Woman": Hypertrichosis and the Construction of Gender in the Age of Darwin ... Ferriman-Gallwey score Taylor, Sarah K (June 18, 2009). "Congenital Hypertrichosis Lanuginosa". Emedicine. Medscape. Retrieved ... or a rare genetic disorder known as hypertrichosis. In some cases, a woman's ability to grow a beard can be due to hereditary ...
Alice Elizabeth Doherty
Doherty had hypertrichosis lanuginosa. Although this condition is very rare, other individuals were known for their similar ... Alice Elizabeth Doherty (March 14, 1887 - June 13, 1933) was an American woman born with the condition hypertrichosis ... Hypertrichosis has many different variations, including differences in causation. She was exhibited by her parents as a ... People with hypertrichosis, Sideshow attractions, Women in Minnesota, 20th-century American women, 20th-century American people ...
Moon of Desire
She has a medical condition called Hypertrichosis. Meg Imperial as Ayla "DJ Lav" Ricafrente-Bustamante / Angel Comia JC de Vera ...
Management of hair loss
Tosti A, Pazzaglia M, Voudouris S, Tosti G (November 2004). "Hypertrichosis of the eyelashes caused by bimatoprost". Journal of ...
Charles Haskell Danforth
Danforth, C. H. (1925). "Studies on hair: with special reference to hypertrichosis". Archives of Dermatology and Syphilology. ...
Jesús Aceves
His sister, Lili, was also born with hypertrichosis. She is married with one son, and works as a police officer in Mexico. Many ... is the second person in his family born with a rare condition known as hypertrichosis. He is married and has two daughters, ...
History of radiation therapy
... in hypertrichosis, for the removal of unwanted hair; 2. in the treatment of disease of hair and hair follicles in which it was ...
Michelin tire baby syndrome
Pivnick EK, Wilroy RS, Martens PR, Teather TC, Hashimoto K (April 1996). "Hypertrichosis, pigmentary retinopathy, and facial ...
Eccrine angiomatous hamartoma
Hypertrichosis of the tumor is encountered in most cases. Hyperhidrosis is an additional diagnostic feature that is seen in ... Tufted angioma Smooth muscle hamartoma - These flesh-colored plaques may have associated hypertrichosis. A "chicken-skin" ...
The True Adventures of Wolfboy
It tells the story of a teenage boy with hypertrichosis who leaves home to find his mother while befriending a "mermaid" ... Jaeden Martell as Paul Harker, a boy with hypertrichosis. Sophie Giannamore as Aristiana, a "mermaid" transgender girl and ... Stephen McKinley Henderson as Nicholas, Paul's estranged grandfather who lives with Jen and also suffers from hypertrichosis. ...
Human Nature (2001 film)
It tells the story of three people-a writer with hypertrichosis, a man who was raised as an ape away from civilization, and a ... a writer with hypertrichosis. Hilary Duff as Young Lila Jute Tim Robbins as Nathan Bronfman, a psychologist. Chase MacKenzie ...
Ear hair
Severe hypertrichosis of the external ear during minoxidil therapy, where excessive hair covers the ears, may cause ear canal ... Toriumi, MD, Dean; Raymond, Konior, MD; Berktold, MD, Robert (August 1988). "Severe hypertrichosis of the external ear canal ... hypertrichosis lanuginosa acquisita). Hair is a protein filament that grows from follicles in the dermis, or skin. With the ... or even the abnormal hair growth as seen in hypertrichosis and hirsutism. Medical research on the function of ear hair is ...
Stephan Bibrowski
People with hypertrichosis, Sideshow performers, German expatriates in the United States, People from Congress Poland, 19th- ... this was likely due to a rare condition called hypertrichosis. Bibrowski was born in 1890 in Wilczogóra, Grójec County at Gmina ...
Hirsutism
It is different from hypertrichosis, which is excessive hair growth anywhere on the body. Treatments may include certain birth ... If the distribution of hair growth occurs throughout the body, this is referred to as hypertrichosis, not hirsutism. Endocrine ... Chellini PR, Pirmez R, Raso P, Sodré CT (2015). "Generalized Hypertrichosis Induced by Topical Minoxidil in an Adult Woman". ... Dawber RP, Rundegren J (2003). "Hypertrichosis in females applying minoxidil topical solution and in normal controls". J Eur ...
Cantú syndrome
Cantu JM, Garcia-Cruz D, Sanchez-Corona J, Hernandez A, Nazara Z (1982) A distinct osteochondrodysplasia with hypertrichosis-- ... The main features of this condition are hypertrichosis, osteochondrodysplasia, and cardiomegaly. There is also a characteristic ... Cantú syndrome is a rare condition characterized by hypertrichosis, osteochondrodysplasia, and cardiomegaly. Less than 50 cases ...
Chest hair
An excessive growth of terminal hair on the body is called hypertrichosis. This medical term has to be distinguished from ...
List of OMIM disorder codes
... with hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, and hypogonadism; 612391; SLC29A3 Hyperpigmentation, ...
HirsutismLocalized hypertrichosis CongenitalCongenital hypertrichosis lanuginosaGeneralized hypertrichosis terminalisKnown as hypertrichosisAssociated with underlyingUniversalisAbnormalMinoxidilJulia PastranaSyndromeElbowsFamilialCubitiMalignancyDisordersPubertyHyperpigmentationHairinessDeformityAbnormally excessiveFacialCommonlyDiagnosisHair growthConditionGeneticSkinCircusOccursRareTerminologyCaseWomenFamilyFormsGrowthPresentDiseaseCasesBodyTreatmentPatientPerson
Hirsutism2
- Hypertrichosis is often mistakenly classified as hirsutism. (wikipedia.org)
- Hirsutism is a type of hypertrichosis exclusive to women and children, resulting from an excess of androgen-sensitive hair growth. (wikipedia.org)
Localized hypertrichosis Congenital1
- Localized hypertrichosis Congenital localized hypertrichosis is a localized increase in hair density and length. (wikipedia.org)
Congenital hypertrichosis lanuginosa8
- Hypertrichosis lanuginosa Congenital hypertrichosis lanuginosa can be noticed at birth, with the infant completely covered in thin lanugo hair. (wikipedia.org)
- however, in a person with congenital hypertrichosis lanuginosa, the lanugo hair remains after birth. (wikipedia.org)
- Congenital hypertrichosis lanuginosa (CHL) has been referred to variably as congenital hypertrichosis universalis, hypertrichosis universalis, hypertrichosis lanuginosa, and hypertrichosis lanuginosa universalis. (medscape.com)
- However, the X-linked syndrome of hypertrichosis associated with gingival hyperplasia is often confused with congenital hypertrichosis lanuginosa. (medscape.com)
- Of interest, Julia Pastrana (1834-1860), one of the most famous persons with generalized hypertrichosis, was long thought to have congenital hypertrichosis lanuginosa. (medscape.com)
- After her death, her hairs were found to actually be terminal in nature, indicating that she likely had hypertrichosis with gingival hyperplasia and not congenital hypertrichosis lanuginosa. (medscape.com)
- Hence, they can be distinguished from congenital hypertrichosis lanuginosa on the basis of their clinical presentations. (medscape.com)
- The hairy family of Burma has a 4-generation pedigree of congenital hypertrichosis lanuginosa dating back to 1826. (medscape.com)
Generalized hypertrichosis terminalis2
- Congenital generalized hypertrichosis terminalis. (barnesandnoble.com)
- A 31-year-old Chinese man whose body is 96 per cent coated in hair has an extra chunk of DNA that could explain his condition - called congenital generalized hypertrichosis terminalis (CGHT). (newscientist.com)
Known as hypertrichosis1
- The syndrome is medically known as hypertrichosis, a condition characterized by an abnormal amount of hair growth. (iflscience.com)
Associated with underlying1
- [ 22 ] These forms represent limited types of hypertrichosis that may be associated with underlying bone and neurologic abnormalities. (medscape.com)
Universalis1
- To avoid confusion in the terminology, we propose to name this type of hypertrichosis Ambras syndrome in reference to the first documented family with congenital hypertrichosis universalis in the 16th century. (symptoma.com)
Abnormal3
- Hypertrichosis is an abnormal amount of hair growth over the body. (wikipedia.org)
- Hypertrichosis is increased hair growth that is abnormal in quantity or location. (beds.ac.uk)
- Paul has congenital hypertrichosis, a condition that causes abnormal hair growth all over his face and body. (rogerebert.com)
Minoxidil2
- Generalised acquired hypertrichosis may be associated with: Porphyria cutanea tarda Malnutrition, eg anorexia nervosa Malignancy Drug, eg ciclosporin, phenytoin, androgenic steroids, minoxidil. (symptoma.com)
- Honestly brah I am amazed by those who can take oral minoxidil and not getting huge dark circle and hypertrichosis. (hairlosstalk.com)
Julia Pastrana1
- Several circus sideshow performers in the 19th and early 20th centuries, such as Julia Pastrana, had hypertrichosis. (wikipedia.org)
Syndrome5
- Hairy elbow syndrome, a type of congenital circumscribed hypertrichosis, shows excessive growth on and around the elbows. (wikipedia.org)
- An X-linked syndrome of hypertrichosis associated with gingival hyperplasia has been described. (medscape.com)
- and, in 1890, Chiari called the syndrome "hypertrichosis of the dog-men. (medscape.com)
- We report a case of transient neonatal cutis laxa and hypertrichosis lanuginosa as an initial presentation in Sotos syndrome. (symptoma.com)
- Familial hypertrichosis cubiti: hairy elbows syndrome. (nih.gov)
Elbows1
- Hypertrichosis cubiti (hairy elbows) and short stature: a recognisable association. (nih.gov)
Familial1
- It also occurs in rare familial disorders called congenital hypertrichosis. (msdmanuals.com)
Malignancy1
- It is similar to acquired generalized hypertrichosis and is a sign of internal malignancy. (wikipedia.org)
Disorders2
- In the past, persons with congenital disorders that cause excessive body-hair growth have been so dramatized and romanticized that individuals with rare hypertrichosis syndromes became crowd-drawing money-making phenomena in many 19th century sideshow acts. (medscape.com)
- Disorders of hypertrichosis are distinguished by the distribution of hair, as well as by the temporal pattern of growth, the possible associated congenital anomalies, and the possible inheritance pattern. (medscape.com)
Puberty2
- This type of hypertrichosis is present at birth, becomes more prominent during aging, and regresses at puberty. (wikipedia.org)
- It is hypothesized that these nevi have an increased number of androgen receptors, which can explain the typical history of onset around puberty and hypertrichosis of the nevus. (contemporarypediatrics.com)
Hyperpigmentation1
- Other common features include skin fragility, with minor trauma causing blister formation, hypertrichosis, skin hyperpigmentation, and dark or reddish urine. (bmj.com)
Hairiness1
- JG Thirlwell recently finished scoring a documentary about a family in Mexico with congenital hypertrichosis , a rare condition that results in extreme hairiness, including hair growing from the face. (foetus.org)
Deformity1
- Another deformity associated with acquired generalized hypertrichosis is multiple hairs occupying the same follicle. (wikipedia.org)
Abnormally excessive1
- Hypertrichosis, or werewolf's disease, refers to an abnormally excessive hair growing on the body. (naturalcurefor.com)
Facial1
- Successful treatment of facial hypertrichosis in women. (homoeo.pk)
Commonly2
- Generalized hypertrichosis Acquired generalized hypertrichosis commonly affects the cheeks, upper lip, and chin. (wikipedia.org)
- Medical conditions Acquired hypertrichosis lanuginosa is commonly present with cancer. (symptoma.com)
Diagnosis1
- Diagnosis is usually made by history and physical examination in a patient who has a hyperpigmented patch with hypertrichosis on the shoulder or back. (contemporarypediatrics.com)
Hair growth3
- Patterned hypertrichosis Acquired patterned hypertrichosis is an increase in hair growth in a pattern formation. (wikipedia.org)
- Hypertrichosis is a hair growth variation brought about by genetic factors. (naturalcurefor.com)
- Hypertrichosis involves nonandrogenic hair growth. (msdmanuals.com)
Condition2
- Hypertrichosis is a condition where there is excessive growth of hair in generalized or localized pattern but this is not of male pattern of distribution. (medicosnotes.com)
- Hypertrichosis is a separate condition. (msdmanuals.com)
Genetic3
- Congenital forms of hypertrichosis are caused by genetic mutations, and are extremely rare, unlike acquired forms. (wikipedia.org)
- The cause of hypertrichosis is unclear, although it's thought to be associated with a genetic disorder, malnutrition, the presence of a malignant tumor, or - like this case - the effect of a drug. (iflscience.com)
- Jesús 'Chuy' Aceves and his family of 30 in Loreto, Mexico, are known for having thick, black hair on their faces due to a genetic mutation called Congenital Hypertrichosis . (huffingtonpost.co.uk)
Skin1
- Other cutaneous manifestations include hypertrichosis (most frequently seen on the temples and cheeks) and scleroderma-like skin changes. (clinicaladvisor.com)
Circus1
- Two people with an extreme case of hypertrichosis as shown on a poster for a circus in 19th-Century London. (iflscience.com)
Occurs1
- The two distinct types of hypertrichosis are generalized hypertrichosis, which occurs over the entire body, and localized hypertrichosis, which is restricted to a certain area. (wikipedia.org)
Rare1
- Hypertrichosis is incredibly rare with less than 50 cases officially documented worldwide. (iflscience.com)
Terminology1
- The lack of definitive terminology can be confusing and may make the distinction of the related but unique hypertrichosis syndromes difficult. (medscape.com)
Case1
- Circumscribed signifies this type of hypertrichosis is restricted to certain parts of the body, in this case, the extensor surfaces of the upper extremities. (wikipedia.org)
Women1
- Chuy has three daughters from three different women, and all three daughters have congenital hypertrichosis. (huffingtonpost.co.uk)
Family2
- In 1648, Aldrovandus first documented a family with hypertrichosis. (medscape.com)
- The first person in the family to have hypertrichosis was Chuy's great grandmother, and since then 30 family members have been born with it (about half of the babies born into the family have it). (huffingtonpost.co.uk)
Forms1
- The disease is one of at least several forms of hypertrichosis - all characterised by overgrowth of hair. (newscientist.com)
Growth1
- Hypertrichosis lanuginosa Acquired hypertrichosis lanuginosa is characterized by rapid growth of lanugo hair, particularly on the face. (wikipedia.org)
Present3
- Hypertrichosis can be either congenital (present at birth) or acquired later in life. (wikipedia.org)
- Congenital hypertrichosis is always present at birth. (wikipedia.org)
- Nevoid hypertrichosis Nevoid hypertrichosis may be present at birth or appear later in life. (wikipedia.org)
Disease1
- Children with intestinal malabsorption like celiac disease and a woman with anorexia nervosa have been found to have diffuse lanugo-like hypertrichosis. (symptoma.com)
Cases2
- Over the next 300 years, more than 50 similar-appearing cases were described, and 34 patients with presumed congenital hypertrichosis were identified. (medscape.com)
- Hypertrichosis cases have been reported also after being diagnosed with cancer. (symptoma.com)
Body1
- Terminal hypertrichosis Congenital terminal hypertrichosis is characterized by the presence of fully pigmented terminal hair that covers the entire body. (wikipedia.org)
Treatment1
- There is no treatment for the hypertrichosis. (naturalcurefor.com)
Patient1
- Unusual features in this patient were high degree of photosensitivity and marked hypertrichosis. (karger.com)
Person1
- As the person ages, the lanugo hair may thin, leaving only limited areas of hypertrichosis. (wikipedia.org)