Tumors or cancer of the HYPOPHARYNX.
The bottom portion of the pharynx situated below the OROPHARYNX and posterior to the LARYNX. The hypopharynx communicates with the larynx through the laryngeal inlet, and is also called laryngopharynx.
Surgical removal of a part of the pharynx. (Dorland, 28th ed)
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.
Total or partial excision of the larynx.
The largest cartilage of the larynx consisting of two laminae fusing anteriorly at an acute angle in the midline of the neck. The point of fusion forms a subcutaneous projection known as the Adam's apple.
Tumors or cancer of the PHARYNX.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Pathological processes involving the PHARYNX.
Tumors or cancer of the OROPHARYNX.
A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).
Glands of external secretion that release its secretions to the body's cavities, organs, or surface, through a duct.
Reconstructive surgical procedures in the NECK region to restore or improve form and function.
A thin leaf-shaped cartilage that is covered with LARYNGEAL MUCOSA and situated posterior to the root of the tongue and HYOID BONE. During swallowing, the epiglottis folds back over the larynx inlet thus prevents foods from entering the airway.
A mass of tissue that has been cut away from its surrounding areas to be used in TISSUE TRANSPLANTATION.
Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
A syndrome of DYSPHAGIA with IRON-DEFICIENCY ANEMIA that is due to congenital anomalies in the ESOPHAGUS (such as cervical esophageal webs). It is known as Patterson-Kelly syndrome in the United Kingdom.
A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.
Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.
Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Examination, therapy or surgery of the interior of the larynx performed with a specially designed endoscope.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
A natural fuel formed by partial decomposition of vegetable matter under certain environmental conditions.
Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.
Tumors or cancer of the MOUTH.

Sternothoracotomy for combined coronary artery bypass grafting and left upper lobectomy in a patient with low-lying tracheostoma. (1/186)

A 64-year-old man had a low-lying tracheostoma and presented with unstable angina and a mass in the pulmonary left upper lobe. Simultaneous coronary revascularization and resection of the lung neoplasm were completed through a sternothoracotomy (clam-shell) incision. The advantages of this approach include excellent exposure to the mediastinum and the lung fields, and the option of using both internal thoracic arteries for bypass grafting.  (+info)

Cytomegalovirus colitis after administration of docetaxel-5-fluorouracil-cisplatin chemotherapy for locally advanced hypopharyngeal cancer. (2/186)

We present the case of a patient with a locally advanced hypopharyngeal carcinoma who developed a severe cytomegalovirus (CMV) colitis after his first chemotherapy course with 5-fluorouracil (5-FU), docetaxel and cisplatin. The most probable cause of his CMV colitis is the impaired immunity during a phase of neutropenia after the chemotherapy. Although there was amelioration of the colitis and clinical status after treatment with ganciclovir, the patient later deteriorated and died due to recurrent bacterial infections. This is the third reported case of CMV colitis treated with ganciclovir in a patient with a solid tumour. It is the first report of CMV colitis after docetaxel containing chemotherapy. Although CMV colitis is most frequently observed in immunosuppressed patients such as those with acquired immune deficiency syndrome (AIDS), transplants and corticosteroid treatment, it has also been reported in less immunosuppressed (elderly, malnourished,...) and even non-immunosuppressed patients. CMV infection should therefore be included in the differential diagnosis of GI disease in all patients, and when suspected, the clinician should pursue appropriate diagnostic and therapeutic interventions.  (+info)

Sonographic findings of the neopharynx after total laryngectomy: comparison with CT. (3/186)

BACKGROUND AND PURPOSE: To our knowledge, sonographic findings in the neopharynx have not been well characterized. We describe our results and assess the role of sonography versus CT in patients who have undergone total laryngectomy. METHODS: We examined 25 patients (24 men and one woman; 44-78 years old) who had had a total laryngectomy. Sonography (with a 10-MHz transducer) and contrast-enhanced CT were performed in all patients. We evaluated the normal shape of the neopharynx and assessed the accuracy of sonography versus CT in detecting tumor recurrence in the neck. RESULTS: The neopharynx appears as a round or ovoid structure on imaging studies. On sonograms, the neopharyngeal wall has five layers of alternating echogenicity: an innermost hyperechoic layer of superficial mucosa, an inner hypoechoic layer of deep mucosa, a middle hyperechoic layer of submucosa, an outer hypoechoic layer of muscle, and an outermost hyperechoic layer of adventitia. On CT scans, the neopharynx appears as a three-layered structure, with an inner hyperdense layer of mucosa, a middle hypodense layer of submucosa, and an outer isodense layer of pharyngeal constrictor muscles. Nine pathologically proved recurrences were found: three local recurrences, one local recurrence with lymph node metastasis, and five cases of lymph node metastasis only. One instance of false-negative lymph node metastasis was seen at sonography and one case of false-positive local recurrence was seen at CT. CONCLUSION: The neopharynx has a unique sonographic appearance, and this imaging technique is useful for detecting local tumor recurrence in the neopharynx in patients who have had a total laryngectomy.  (+info)

Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas. (4/186)

Tumour oxygenation and vasculature are determinants for radiation treatment outcome and prognosis in patients with squamous cell carcinomas of the head and neck. In this study we visualized and quantified these factors which may provide a predictive tool for new treatments. Twenty-one patients with stage III-IV squamous cell carcinomas of the head and neck were intravenously injected with pimonidazole, a bioreductive hypoxic marker. Tumour biopsies were taken 2 h later. Frozen tissue sections were stained for vessels and hypoxia by fluorescent immunohistochemistry. Twenty-two sections of biopsies of different head and neck sites were scanned and analysed with a computerized image analysis system. The hypoxic fractions varied from 0.02 to 0.29 and were independent from T- and N-classification, localization and differentiation grade. No significant correlation between hypoxic fraction and vascular density was observed. As a first attempt to categorize tumours based on their hypoxic profile, three different hypoxia patterns are described. The first category comprised tumours with large hypoxic, but viable, areas at distances even greater than 200 micrometer from the vessels. The second category showed a typical band-like distribution of hypoxia at an intermediate distance (50-200 micrometer) from the vessels with necrosis at greater distances. The third category demonstrated hypoxia already within 50 micrometer from the vessels, suggestive for acute hypoxia. This method of multiparameter analysis proved to be clinically feasible. The information on architectural patterns and the differences that exist between tumours can improve our understanding of the tumour micro-environment and may in the future be of assistance with the selection of (oxygenation modifying) treatment strategies.  (+info)

Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: a case-control study in France. (5/186)

OBJECTIVES: A case-control study was conducted in France to assess possible associations between occupational exposures and squamous cell carcinomas of the larynx and hypopharynx. METHODS: The study was restricted to men, and included 201 hypopharyngeal cancers, 296 laryngeal cancers, and 296 controls (patients with other tumour sites). Detailed information on smoking, alcohol consumption, and lifetime occupational history was collected. Occupational exposure to seven substances (formaldehyde, leather dust, wood dust, flour dust, coal dust, silica dust, and textile dust) was assessed with a job exposure matrix. Exposure variables used in the analysis were probability, duration, and cumulative level of exposure. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression, and were adjusted for major confounding factors (age, smoking, alcohol, and when relevant other occupational exposures). RESULTS: Hypopharyngeal cancer was found to be associated with exposure to coal dust (OR 2.31, 95% CI 1.21 to 4.40), with a significant rise in risk with probability (p<0.005 for trend) and level (p<0.007 for trend) of exposure. Exposure to coal dust was also associated with an increased risk of laryngeal cancer (OR 1.67, 95% CI 0.92 to 3.02), but no dose-response pattern was found. A significant relation, limited to hypopharyngeal cancer, was found with the probability of exposure to formaldehyde (p<0.005 for trend), with a fourfold risk for the highest category (OR 3.78, 95% CI 1.50 to 9.49). When subjects exposed to formaldehyde with a low probability were excluded, the risk also increased with duration (p<0.04) and cumulative level of exposure (p<0.14). No significant association was found for any other substance. CONCLUSION: These results indicate that exposure to formaldehyde and coal dust may increase the risk of hypopharyngeal cancer.  (+info)

Nuclear beta catenin expression is related to unfavourable outcome in oropharyngeal and hypopharyngeal squamous cell carcinoma. (6/186)

AIMS: To investigate the expression of alpha, beta, and gamma catenins in oropharyngeal and hypopharyngeal squamous cell carcinoma and their relations to each other, as well as to clinical data, tumour differentiation, and prognosis. METHODS: Primary tumours for analysis were obtained from 138 patients diagnosed with squamous cell carcinoma of the oropharynx or hypopharynx between 1975 and 1998 in eastern Finland. Immunohistochemistry was used to evaluate the expression of alpha, beta, and gamma catenins. The expression patterns of all catenins were related to clinical data and survival. RESULTS: The expression patterns of all three catenins were significantly interrelated. Reduced gamma catenin expression was significantly associated with poor histological differentiation. No association was found between alpha or beta catenin expression and clinicopathological characteristics. In univariate analysis, patients whose tumours had nuclear beta catenin expression had shorter overall survival than patients with no nuclear expression. In Cox multivariate analysis, nuclear beta catenin expression, tumour status (T class), and Karnofsky performance index were independent prognostic factors of overall survival. CONCLUSIONS: Reduced expression of gamma catenin is associated with dedifferentiation in primary squamous cell carcinoma of the oropharynx and hypopharynx. The fact that nuclear beta catenin expression independently predicts short overall survival suggests that it might be a valuable prognostic marker in pharyngeal squamous cell carcinoma.  (+info)

P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? (7/186)

P73, a p53-homologue gene, has been studied for its possible role in head and neck squamous epithelium (HNSE) differentiation and carcinogenesis. P73 RNA and protein were analysed in 50 biopsies, including well- and moderately-differentiated carcinomas, and 21 matched normal adjacent tissues. P73 immunohistochemical analyses revealed intense p73 nuclear staining in basal and parabasal cells of normal squamous epithelium, in contrast with complete absence of staining in the more superficial cell layers. Moderately-differentiated carcinomas demonstrated homogeneous and diffuse staining in all tumour cells, while only basal cells were stained in well-differentiated carcinomas as in normal tissue. No correlation was observed between p73 and p53 protein expression. Immunostaining for p63, another p53-related protein previously described as being involved in HNSE morphogenesis and overexpressed in head and neck squamous cell carcinomas (HNSCC), was found to be similar to p73 labelling in carcinomas, but spread to the more differentiated layers in normal epithelium. Biallelic expression of p73 was found in tumours as well as in matched normal tissues. Comparison of p73 transcript levels between tumours and normal tissues showed decreased mRNA expression in 5/17 (30%) tumours independently of the differentiation status. Mutation and loss of heterozygosity analyses of the p73 gene revealed wild type status and no deletion. Our results strongly suggest that: (i) p73 is associated with homeostasis and control of differentiation of head and neck squamous epithelium probably in concert with p53 and p63; (ii) down-regulation of p73 expression could participate in HNSE carcinogenesis.  (+info)

Laryngeal and hypopharyngeal carcinoma: comparison of helical CT multiplanar reformation, three-dimensional reconstruction and virtual laryngoscopy. (8/186)

OBJECTIVE: To evaluate the clinical application of helical CT multiplanar reformation (MPR) three-dimensional reconstruction (3D) and virtual laryngoscopy (CTVL) in laryngeal and hypopharyngeal carcinoma. METHODS: Axial helical CT scans were performed in 22 patients with laryngeal or hypopharyngeal carcinoma, along with MPR, 3D and CTVL. These results were compared with the findings of fiber optic laryngoscopy and surgery. RESULTS: Combining axial and MPR images, both the accuracy in preoperative tumor staging and the diagnosis of metastatic lymph nodes were 95%. MPR demonstrated more information about the extent of tumor than axial images in 23% cases; 3D image displayed clearly the extension of tumor, the vessels and airway from multiple views. The location, size and extent of tumors found in cranio-caudal CTVL corresponded well with that of laryngoscopy, and CTVL demonstrated the relationship between the tumor and vocal cords and anterior commissure by caudo-cranial approach, which was inaccessible to fiber optic laryngoscopy in 3 cases. CONCLUSIONS: Axial images of helical CT clearly demonstrate the location, size and extent of laryngeal and hypopharyngeal carcinoma, while MPR and 3D images are useful in displaying the three-dimensional images and anatomical relation of the tumor. CTVL can clearly display the mucosal surface structures of the larynx and hypopharynx and is a good complementary method of laryngoscopy.  (+info)

Hypopharyngeal neoplasms refer to abnormal growths or tumors in the hypopharynx, which is the lower part of the pharynx or throat. These growths can be benign (non-cancerous) or malignant (cancerous). Malignant hypopharyngeal neoplasms are often squamous cell carcinomas and are aggressive with a poor prognosis due to their location and tendency to spread early. They can cause symptoms such as difficulty swallowing, pain when swallowing, sore throat, ear pain, and neck masses. Risk factors for hypopharyngeal cancer include smoking, heavy alcohol consumption, and poor nutrition.

The hypopharynx is the lower part of the pharynx, which is the muscular tube that extends from the back of the nasal cavity and mouth to the esophagus and trachea. The hypopharynx lies posterior to the larynx and is divided into three regions: the pyriform (or piriform) sinuses, the postcricoid area, and the posterior pharyngeal wall. It serves as a passageway for both food and air, and any abnormalities or diseases in this region can lead to swallowing difficulties, aspiration, and other serious medical conditions.

A pharyngectomy is a surgical procedure that involves the removal of all or part of the pharynx, which is the muscular tube that extends from the back of the nasal cavity and mouth to the esophagus. This procedure is typically performed to treat cancers of the head and neck, such as throat cancer, that have invaded the tissues of the pharynx.

During a pharyngectomy, an incision is made in the neck or chest, depending on the location of the tumor. The surgeon then carefully dissects the pharynx away from surrounding structures, such as the esophagus, carotid artery, and spinal cord. Depending on the extent of the cancer, nearby lymph nodes may also be removed.

After the pharynx has been removed, the surgeon will reconstruct the area using tissue from another part of the body, such as the forearm or leg. This reconstruction is necessary to restore normal functions such as swallowing and speaking.

Pharyngectomy is a complex surgical procedure that requires extensive training and expertise. It carries significant risks, including bleeding, infection, and damage to surrounding structures. However, for some patients with advanced throat cancer, it may be the best option for achieving long-term survival.

Laryngeal neoplasms refer to abnormal growths or tumors in the larynx, also known as the voice box. These growths can be benign (non-cancerous) or malignant (cancerous). Laryngeal neoplasms can affect any part of the larynx, including the vocal cords, epiglottis, and the area around the vocal cords called the ventricle.

Benign laryngeal neoplasms may include papillomas, hemangiomas, or polyps. Malignant laryngeal neoplasms are typically squamous cell carcinomas, which account for more than 95% of all malignant laryngeal tumors. Other types of malignant laryngeal neoplasms include adenocarcinoma, sarcoma, and lymphoma.

Risk factors for developing laryngeal neoplasms include smoking, alcohol consumption, exposure to industrial chemicals, and a history of acid reflux. Symptoms may include hoarseness, difficulty swallowing, sore throat, ear pain, or a lump in the neck. Treatment options depend on the type, size, location, and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.

The larynx, also known as the voice box, is a complex structure in the neck that plays a crucial role in protection of the lower respiratory tract and in phonation. It is composed of cartilaginous, muscular, and soft tissue structures. The primary functions of the larynx include:

1. Airway protection: During swallowing, the larynx moves upward and forward to close the opening of the trachea (the glottis) and prevent food or liquids from entering the lungs. This action is known as the swallowing reflex.
2. Phonation: The vocal cords within the larynx vibrate when air passes through them, producing sound that forms the basis of human speech and voice production.
3. Respiration: The larynx serves as a conduit for airflow between the upper and lower respiratory tracts during breathing.

The larynx is located at the level of the C3-C6 vertebrae in the neck, just above the trachea. It consists of several important structures:

1. Cartilages: The laryngeal cartilages include the thyroid, cricoid, and arytenoid cartilages, as well as the corniculate and cuneiform cartilages. These form a framework for the larynx and provide attachment points for various muscles.
2. Vocal cords: The vocal cords are thin bands of mucous membrane that stretch across the glottis (the opening between the arytenoid cartilages). They vibrate when air passes through them, producing sound.
3. Muscles: There are several intrinsic and extrinsic muscles associated with the larynx. The intrinsic muscles control the tension and position of the vocal cords, while the extrinsic muscles adjust the position and movement of the larynx within the neck.
4. Nerves: The larynx is innervated by both sensory and motor nerves. The recurrent laryngeal nerve provides motor innervation to all intrinsic laryngeal muscles, except for one muscle called the cricothyroid, which is innervated by the external branch of the superior laryngeal nerve. Sensory innervation is provided by the internal branch of the superior laryngeal nerve and the recurrent laryngeal nerve.

The larynx plays a crucial role in several essential functions, including breathing, speaking, and protecting the airway during swallowing. Dysfunction or damage to the larynx can result in various symptoms, such as hoarseness, difficulty swallowing, shortness of breath, or stridor (a high-pitched sound heard during inspiration).

A laryngectomy is a surgical procedure that involves the removal of the larynx, also known as the voice box. This is typically performed in cases of advanced laryngeal cancer or other severe diseases of the larynx. After the surgery, the patient will have a permanent stoma (opening) in the neck to allow for breathing. The ability to speak after a total laryngectomy can be restored through various methods such as esophageal speech, tracheoesophageal puncture with a voice prosthesis, or electronic devices.

Thyroid cartilage is the largest and most superior of the laryngeal cartilages, forming the front and greater part of the larynx, also known as the "Adam's apple" in humans. It serves to protect the vocal cords and provides attachment for various muscles involved in voice production. The thyroid cartilage consists of two laminae that join in front at an angle, creating a noticeable prominence in the anterior neck. This structure is crucial in speech formation and swallowing functions.

Pharyngeal neoplasms refer to abnormal growths or tumors in the pharynx, which is the part of the throat that lies behind the nasal cavity and mouth, and above the esophagus and larynx. These growths can be benign (non-cancerous) or malignant (cancerous).

Pharyngeal neoplasms can occur in any part of the pharynx, which is divided into three regions: the nasopharynx, oropharynx, and hypopharynx. The most common type of pharyngeal cancer is squamous cell carcinoma, which arises from the flat cells that line the mucosal surface of the pharynx.

Risk factors for developing pharyngeal neoplasms include tobacco use, heavy alcohol consumption, and infection with human papillomavirus (HPV). Symptoms may include sore throat, difficulty swallowing, ear pain, neck masses, and changes in voice or speech. Treatment options depend on the type, size, location, and stage of the neoplasm, and may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Squamous cell carcinoma is a type of skin cancer that begins in the squamous cells, which are flat, thin cells that form the outer layer of the skin (epidermis). It commonly occurs on sun-exposed areas such as the face, ears, lips, and backs of the hands. Squamous cell carcinoma can also develop in other areas of the body including the mouth, lungs, and cervix.

This type of cancer usually develops slowly and may appear as a rough or scaly patch of skin, a red, firm nodule, or a sore or ulcer that doesn't heal. While squamous cell carcinoma is not as aggressive as some other types of cancer, it can metastasize (spread) to other parts of the body if left untreated, making early detection and treatment important.

Risk factors for developing squamous cell carcinoma include prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds, fair skin, a history of sunburns, a weakened immune system, and older age. Prevention measures include protecting your skin from the sun by wearing protective clothing, using a broad-spectrum sunscreen with an SPF of at least 30, avoiding tanning beds, and getting regular skin examinations.

Pharyngeal diseases refer to conditions that affect the pharynx, which is the part of the throat that lies behind the nasal cavity and mouth, and above the esophagus and larynx. The pharynx plays a crucial role in swallowing, speaking, and breathing. Pharyngeal diseases can cause symptoms such as sore throat, difficulty swallowing, pain during swallowing, swollen lymph nodes, and earaches.

Some common pharyngeal diseases include:

1. Pharyngitis: Inflammation of the pharynx, often caused by a viral or bacterial infection.
2. Tonsillitis: Inflammation of the tonsils, which are two masses of lymphoid tissue located on either side of the back of the throat.
3. Epiglottitis: Inflammation of the epiglottis, a flap of cartilage that covers the windpipe during swallowing to prevent food and liquids from entering the lungs.
4. Abscesses: A collection of pus in the pharynx caused by a bacterial infection.
5. Cancer: Malignant tumors that can develop in the pharynx, often caused by smoking or heavy alcohol use.
6. Dysphagia: Difficulty swallowing due to nerve damage, muscle weakness, or structural abnormalities in the pharynx.
7. Stridor: Noisy breathing caused by a narrowed or obstructed airway in the pharynx.

Treatment for pharyngeal diseases depends on the underlying cause and may include antibiotics, pain relievers, surgery, or radiation therapy.

Oropharyngeal neoplasms refer to abnormal growths or tumors in the oropharynx, which is the middle part of the pharynx (throat) that includes the back one-third of the tongue, the soft palate, the side and back walls of the throat, and the tonsils. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Oropharyngeal cancer is a significant global health concern, with squamous cell carcinoma being the most common type of malignant neoplasm in this region. The primary risk factors for oropharyngeal cancers include tobacco use, alcohol consumption, and human papillomavirus (HPV) infection. Early detection and treatment are crucial for improving outcomes and survival rates.

The pharynx is a part of the digestive and respiratory systems that serves as a conduit for food and air. It is a musculo-membranous tube extending from the base of the skull to the level of the sixth cervical vertebra where it becomes continuous with the esophagus.

The pharynx has three regions: the nasopharynx, oropharynx, and laryngopharynx. The nasopharynx is the uppermost region, which lies above the soft palate and is connected to the nasal cavity. The oropharynx is the middle region, which includes the area between the soft palate and the hyoid bone, including the tonsils and base of the tongue. The laryngopharynx is the lowest region, which lies below the hyoid bone and connects to the larynx.

The primary function of the pharynx is to convey food from the oral cavity to the esophagus during swallowing and to allow air to pass from the nasal cavity to the larynx during breathing. It also plays a role in speech, taste, and immune defense.

Exocrine glands are a type of gland in the human body that produce and release substances through ducts onto an external or internal surface. These glands are responsible for secreting various substances such as enzymes, hormones, and lubricants that help in digestion, protection, and other bodily functions.

Exocrine glands can be further classified into three types based on their mode of secretion:

1. Merocrine glands: These glands release their secretions by exocytosis, where the secretory product is enclosed in a vesicle that fuses with the cell membrane and releases its contents outside the cell. Examples include sweat glands and mucous glands.
2. Apocrine glands: These glands release their secretions by pinching off a portion of the cytoplasm along with the secretory product. An example is the apocrine sweat gland found in the armpits and genital area.
3. Holocrine glands: These glands release their secretions by disintegrating and releasing the entire cell, including its organelles and secretory products. An example is the sebaceous gland found in the skin, which releases an oily substance called sebum.

Cervicoplasty is a surgical procedure that involves the removal and reconstruction of the cervix, which is the lower part of the uterus. This procedure is typically performed to correct abnormalities or deformities of the cervix, such as those caused by cancer, radiation therapy, or traumatic injury.

During a cervicoplasty, the surgeon removes a portion or all of the cervix and then reconstructs the remaining tissue to restore normal function and appearance. This procedure may be performed using various surgical techniques, including cold knife conization, laser surgery, or loop electrosurgical excision (LEEP).

The specific goals and techniques used in a cervicoplasty will depend on the individual patient's needs and medical history. It is important to discuss the risks and benefits of this procedure with a qualified healthcare provider before making any treatment decisions.

The epiglottis is a flap-like structure located at the base of the tongue, near the back of the throat (pharynx). It is made of elastic cartilage and covered with mucous membrane. The primary function of the epiglottis is to protect the trachea (windpipe) from food or liquids entering it during swallowing.

During normal swallowing, the epiglottis closes over the opening of the larynx (voice box), redirecting the food or liquid bolus into the esophagus. In this way, the epiglottis prevents aspiration, which is the entry of foreign materials into the trachea and lungs.

Inflammation or infection of the epiglottis can lead to a serious medical condition called epiglottitis, characterized by swelling, redness, and pain in the epiglottis and surrounding tissues. Epiglottitis can cause difficulty breathing, speaking, and swallowing, and requires immediate medical attention.

A free tissue flap in medical terms refers to a surgical procedure where living tissue, along with its own blood supply, is lifted from its original location and moved to another part of the body for reconstruction or repair. The term "free" indicates that the tissue is completely detached from its original blood vessels and then reattached to new blood vessels at the recipient site using microvascular surgical techniques.

Free tissue flaps can be composed of various tissues, such as skin, muscle, fascia (the connective tissue beneath the skin), or bone. They are often used in reconstructive surgery following trauma, tumor removal, or for treating complex wounds that cannot heal on their own. The advantages of free tissue flaps include increased flexibility in choosing the type and size of tissue to be transferred, as well as improved blood flow to the transplanted tissue, which can enhance healing and overall surgical success.

Organ sparing treatments refer to medical interventions that are designed to preserve the structure and function of an organ, while still effectively treating the underlying disease or condition. These treatments can include surgical techniques, radiation therapy, or medications that aim to target specific cells or processes involved in the disease, while minimizing damage to healthy tissues.

Organ sparing treatments may be used in a variety of medical contexts, such as cancer treatment, where the goal is to eliminate malignant cells while preserving as much normal tissue as possible. For example, radiation therapy may be delivered with precise techniques that limit exposure to surrounding organs, or medications may be used to target specific receptors on cancer cells, reducing the need for more extensive surgical interventions.

Similarly, in the context of kidney disease, organ sparing treatments may include medications that help control blood pressure and reduce proteinuria (protein in the urine), which can help slow the progression of kidney damage and potentially delay or prevent the need for dialysis or transplantation.

Overall, organ sparing treatments represent an important area of medical research and practice, as they offer the potential to improve patient outcomes, reduce treatment-related morbidity, and maintain quality of life.

Neck dissection is a surgical procedure that involves the removal of lymph nodes and other tissues from the neck. It is typically performed as part of cancer treatment, particularly in cases of head and neck cancer, to help determine the stage of the cancer, prevent the spread of cancer, or treat existing metastases. There are several types of neck dissections, including radical, modified radical, and selective neck dissection, which vary based on the extent of tissue removal. The specific type of neck dissection performed depends on the location and extent of the cancer.

Plummer-Vinson syndrome, also known as Patterson-Kelly syndrome, is a rare disorder that primarily affects middle-aged women. It is characterized by the triad of:

1. Dysphagia (difficulty swallowing) due to web-like narrowing (stenosis) or webs in the upper esophagus (cervical esophagus).
2. Iron deficiency anemia.
3. Glossitis (inflammation and atrophy of the tongue), which can lead to a smooth, beefy red appearance.

The syndrome is associated with various other symptoms such as angular cheilosis (cracks at the corners of the mouth), koilonychias (spoon-shaped nails), and esophageal carcinoma (cancer) in some cases. The exact cause of Plummer-Vinson syndrome remains unclear, but it is thought to be related to chronic nutritional deficiencies, particularly iron and vitamin B12. Treatment typically involves addressing the underlying causes, such as providing iron supplementation for anemia and endoscopic dilation for esophageal webs or stenosis.

Otolaryngology is a specialized branch of medicine that deals with the diagnosis, management, and treatment of disorders related to the ear, nose, throat (ENT), and head and neck region. It's also known as ENT (Ear, Nose, Throat) specialty. Otolaryngologists are physicians trained in the medical and surgical management of conditions such as hearing and balance disorders, nasal congestion, sinusitis, allergies, sleep apnea, snoring, swallowing difficulties, voice and speech problems, and head and neck tumors.

"Bees" are not a medical term, as they refer to various flying insects belonging to the Apidae family in the Apoidea superfamily. They are known for their role in pollination and honey production. If you're looking for medical definitions or information, please provide relevant terms.

Laryngopharyngeal reflux (LPR) is a condition in which the stomach contents, particularly acid, flow backward from the stomach into the larynx (voice box) and pharynx (throat). This is also known as extraesophageal reflux disease (EERD) or supraesophageal reflux disease (SERD). Unlike gastroesophageal reflux disease (GERD), where acid reflux causes symptoms such as heartburn and regurgitation, LPR may not cause classic reflux symptoms, but rather symptoms related to the upper aerodigestive tract. These can include hoarseness, throat clearing, cough, difficulty swallowing, and a sensation of a lump in the throat.

A "second primary neoplasm" is a distinct, new cancer or malignancy that develops in a person who has already had a previous cancer. It is not a recurrence or metastasis of the original tumor, but rather an independent cancer that arises in a different location or organ system. The development of second primary neoplasms can be influenced by various factors such as genetic predisposition, environmental exposures, and previous treatments like chemotherapy or radiation therapy.

It is important to note that the definition of "second primary neoplasm" may vary slightly depending on the specific source or context. In general medical usage, it refers to a new, separate cancer; however, in some research or clinical settings, there might be more precise criteria for defining and diagnosing second primary neoplasms.

Head and neck neoplasms refer to abnormal growths or tumors in the head and neck region, which can be benign (non-cancerous) or malignant (cancerous). These tumors can develop in various sites, including the oral cavity, nasopharynx, oropharynx, larynx, hypopharynx, paranasal sinuses, salivary glands, and thyroid gland.

Benign neoplasms are slow-growing and generally do not spread to other parts of the body. However, they can still cause problems if they grow large enough to press on surrounding tissues or structures. Malignant neoplasms, on the other hand, can invade nearby tissues and organs and may also metastasize (spread) to other parts of the body.

Head and neck neoplasms can have various symptoms depending on their location and size. Common symptoms include difficulty swallowing, speaking, or breathing; pain in the mouth, throat, or ears; persistent coughing or hoarseness; and swelling or lumps in the neck or face. Early detection and treatment of head and neck neoplasms are crucial for improving outcomes and reducing the risk of complications.

Laryngoscopy is a medical procedure that involves the examination of the larynx, which is the upper part of the windpipe (trachea), and the vocal cords using a specialized instrument called a laryngoscope. The laryngoscope is inserted through the mouth or nose to provide a clear view of the larynx and surrounding structures. This procedure can be performed for diagnostic purposes, such as identifying abnormalities like growths, inflammation, or injuries, or for therapeutic reasons, such as removing foreign objects or taking tissue samples for biopsy. There are different types of laryngoscopes and techniques used depending on the reason for the examination and the patient's specific needs.

Maxillary sinus neoplasms refer to abnormal growths or tumors that develop in the maxillary sinuses, which are located in the upper part of your cheekbones, below your eyes. These growths can be benign (non-cancerous) or malignant (cancerous).

Benign neoplasms may include conditions such as an osteoma (a benign bone tumor), a papilloma (a benign growth of the lining of the sinus), or a fibrous dysplasia (a condition where bone is replaced by fibrous tissue).

Malignant neoplasms, on the other hand, can be primary (originating in the maxillary sinuses) or secondary (spreading to the maxillary sinuses from another site in the body). Common types of malignant tumors that arise in the maxillary sinus include squamous cell carcinoma, adenocarcinoma, and mucoepidermoid carcinoma.

Symptoms of maxillary sinus neoplasms may include nasal congestion, nosebleeds, facial pain or numbness, vision changes, and difficulty swallowing or speaking. Treatment options depend on the type, size, and location of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

I apologize for any confusion, but "coal" is not a medical term. Coal is a black or brownish-black sedimentary rock that is formed from the accumulation and preservation of plant materials, usually in a swamp environment. It is commonly used as a fuel source due to its high carbon content. If you have any questions about medical terminology or health-related topics, I would be happy to help answer them.

A surgical flap is a specialized type of surgical procedure where a section of living tissue (including skin, fat, muscle, and/or blood vessels) is lifted from its original site and moved to another location, while still maintaining a blood supply through its attached pedicle. This technique allows the surgeon to cover and reconstruct defects or wounds that cannot be closed easily with simple suturing or stapling.

Surgical flaps can be classified based on their vascularity, type of tissue involved, or method of transfer. The choice of using a specific type of surgical flap depends on the location and size of the defect, the patient's overall health, and the surgeon's expertise. Some common types of surgical flaps include:

1. Random-pattern flaps: These flaps are based on random blood vessels within the tissue and are typically used for smaller defects in areas with good vascularity, such as the face or scalp.
2. Axial pattern flaps: These flaps are designed based on a known major blood vessel and its branches, allowing them to cover larger defects or reach distant sites. Examples include the radial forearm flap and the anterolateral thigh flap.
3. Local flaps: These flaps involve tissue adjacent to the wound and can be further classified into advancement, rotation, transposition, and interpolation flaps based on their movement and orientation.
4. Distant flaps: These flaps are harvested from a distant site and then transferred to the defect after being tunneled beneath the skin or through a separate incision. Examples include the groin flap and the latissimus dorsi flap.
5. Free flaps: In these flaps, the tissue is completely detached from its original blood supply and then reattached at the new site using microvascular surgical techniques. This allows for greater flexibility in terms of reach and placement but requires specialized expertise and equipment.

Surgical flaps play a crucial role in reconstructive surgery, helping to restore form and function after trauma, tumor removal, or other conditions that result in tissue loss.

A mouth neoplasm refers to an abnormal growth or tumor in the oral cavity, which can be benign (non-cancerous) or malignant (cancerous). Malignant mouth neoplasms are also known as oral cancer. They can develop on the lips, gums, tongue, roof and floor of the mouth, inside the cheeks, and in the oropharynx (the middle part of the throat at the back of the mouth).

Mouth neoplasms can have various causes, including genetic factors, tobacco use, alcohol consumption, and infection with human papillomavirus (HPV). Symptoms may include a lump or thickening in the oral soft tissues, white or red patches, persistent mouth sores, difficulty swallowing or speaking, and numbness in the mouth. Early detection and treatment of mouth neoplasms are crucial for improving outcomes and preventing complications.

Hypopharyngeal cancer is a term used for tumors of a subsite of the upper aerodigestive tract, and like most other subsite ... Most hypopharyngeal cancers are squamous cell neoplasms. Nearly 100% of head and neck cancers overexpress epidermal growth ... Management of hypopharyngeal cancer. The management of hypopharyngeal cancer can be broken down based on stage, as follows:. * ... encoded search term (Hypopharyngeal Cancer) and Hypopharyngeal Cancer What to Read Next on Medscape ...
Nasopharynx: Benign and Malignant Neoplasms. *Oropharyngeal Carcinoma, Surgical Approaches, Reconstruction. *Hypopharyngeal and ...
Head and Neck Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, ...
In a retrospective study all patients who underwent chemoradiation for hypopharyngeal and laryngeal carcinoma i … ... Our objective was to evaluate recurrence patterns of hypopharyngeal and laryngeal carcinoma after chemoradiation and options ... Hypopharyngeal Neoplasms / mortality * Hypopharyngeal Neoplasms / surgery* * Hypopharyngeal Neoplasms / therapy * Laryngeal ... Salvage surgery in post-chemoradiation laryngeal and hypopharyngeal carcinoma: outcome and review Acta Otorhinolaryngol Ital. ...
Survival analysis of patients with advanced hypopharyngeal cancer comparing patients who received primary surgery to those who ... Oropharyngeal Neoplasms 97% * Quality-Adjusted Life Years 74% * Head and Neck Neoplasms 73% ... Treatment sequence and survival in locoregionally advanced hypopharyngeal cancer: A surveillance, epidemiology, and end results ...
Testicular Neoplasms, Intestinal Neoplasms, Hypopharyngeal Neoplasms, Penile Neoplasms, Ureteral Neoplasms, Neoplasms, Plasma ... Conditions: Neoplasms, Multiple Myeloma, Pancreatic Neoplasms, Esophageal Neoplasms, Endometrial Neoplasms, Thyroid Neoplasms, ... Urethral Neoplasms, Vaginal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Adenomatous Polyposis Coli, Colorectal Neoplasms, ... Paranasal Sinus Neoplasms, Neoplasms, Unknown Primary, Duodenal Neoplasms, Lip Neoplasms, Thymus Neoplasms, Paraproteinemias ...
Neoplasm of the pharynx*Hypopharyngeal Neoplasm*Malignant Hypopharyngeal Neoplasm*Hypopharyngeal carcinoma*Hypopharyngeal ... Stage I Hypopharyngeal Carcinoma AJCC v6 Stage I Hypopharyngeal Carcinoma AJCC v6. ...
Hypopharyngeal cancer is a term used for tumors of a subsite of the upper aerodigestive tract, and like most other subsite ... Most hypopharyngeal cancers are squamous cell neoplasms. Nearly 100% of head and neck cancers overexpress epidermal growth ... encoded search term (Hypopharyngeal Cancer) and Hypopharyngeal Cancer What to Read Next on Medscape ... The management of hypopharyngeal cancer can be broken down based on stage, as follows:. * T1/T2 - Radiotherapy alone (commonly ...
Neoplasms; Nasopharyngeal Neoplasms; Nasopharyngeal Diseases; Hypopharyngeal Neoplasms. Details ... Colonic Neoplasms; Pancreatic Neoplasms; Neoplasms; Rectal Neoplasms; Ovarian Neoplasms; Head and Neck Neoplasms. Details ... Solid tumours; Liver Neoplasms; Head and Neck Neoplasms; Neoplasms; Pancreatic Neoplasms; Urinary Bladder Neoplasms; Central ... Skin Neoplasms; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Melanoma. Details ...
The purpose of this study is to elucidate the association between PM2.5 and oral neoplasm, including oral potentially malignant ... hypopharyngeal and unspecified pharyngeal cancer. OPMD was defined when individuals were clinical diagnosed as leukoplakia, ... The Association between Ambient Fine Particulate Matter and Oral Neoplasm among Smokers and Betel Quids Chewers Details 2021 - ... 2. Geographically gradients of oral neoplasms by county/city. (a) rate (%) of OPMD and OC cases (b) rate (%) of OPMD cases (c) ...
Hypopharyngeal Neoplasms ... Hypopharyngeal Neoplasms , Hypopharyngeal Neoplasms/etiology , ...
Isolated adrenocorticotropin deficiency induced by pembrolizumab for hypopharyngeal cancer: A case report. Yamamoto, K., ...
Distinct Failure Patterns in Hypopharyngeal Cancer Patients Receiving Surgery-Based Versus Radiation-Based Treatment. Lin, Y. H ... Oropharyngeal Neoplasms 100% * Human papillomavirus 16 88% * Head and Neck Neoplasms 75% ... ASO Visual Abstract: Distinct Failure Patterns in Hypopharyngeal Cancer Patients Receiving Surgery-Based Versus Radiation-Based ...
Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers. ... Role of Total Laryngopharyngoesophagectomy with Gastric Pull Up in the Management of Locally Advanced Hypopharyngeal Cancers. ...
ClinicalTrials.gov: Hypopharyngeal Neoplasms (National Institutes of Health) * ClinicalTrials.gov: Laryngeal Neoplasms ( ... ClinicalTrials.gov: Nasopharyngeal Neoplasms (National Institutes of Health) * ClinicalTrials.gov: Oropharyngeal Neoplasms ( ... Can Laryngeal and Hypopharyngeal Cancers Be Found Early? (American Cancer Society) Also in Spanish ... Can Laryngeal and Hypopharyngeal Cancers Be Prevented? (American Cancer Society) Also in Spanish ...
Hypopharyngeal Neoplasms Medicine & Life Sciences 37% * Pancytopenia Medicine & Life Sciences 31% * Induction Chemotherapy ... A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. Bone ... A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. Bone ... A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. Bone ...
... paranasal sinus neoplasms MeSH C09.647.685.693.575 - maxillary sinus neoplasms MeSH C09.647.710.485 - hypopharyngeal neoplasms ... hypopharyngeal neoplasms MeSH C09.775.549.650 - nasopharyngeal neoplasms MeSH C09.775.549.685 - oropharyngeal neoplasms MeSH ... paranasal sinus neoplasms MeSH C09.603.669.693.575 - maxillary sinus neoplasms MeSH C09.603.692.503 - paranasal sinus neoplasms ... oropharyngeal neoplasms MeSH C09.647.710.685.800 - tonsillar neoplasms MeSH C09.775.350.650 - nasopharyngeal neoplasms MeSH ...
Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect. Here are 22 songs from the 90s and early s with the best ...
Hypopharyngeal squamous cell carcinoma (HSCC) accounts 95% of hypopharyngeal cancer, which is characterized by high early ... RESULTS: The paraglottic space approach can help expose neoplasms under direct vision and save mucosa during surgery while ... In this study, the authors investigated the role of ETS factor, ETS2, in hypopharyngeal cancer pathogenesis in hypopharyngeal ... the role of circRNA in hypopharyngeal cancer has little been investigated. We performed hypopharyngeal carcinoma circRNA ...
Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas. Asian Pac J Cancer Prev. ... Mammary analogue secretory carcinoma presenting as a salivary gland neoplasm. International Journal of Clinical and ... Gene microarray analysis of lncRNA and mRNA expression profiles in patients with hypopharyngeal squamous cell carcinoma. ... AB209630, a long non-coding RNA decreased expression in hypopharyngeal squamous cell carcinoma, influences proliferation, ...
... repair of pharyngeal defect using tongue flaps after resection of advanced stage hypopharyngeal neoplasm and laryngeal neoplasm ... The surgical management of malignant neoplasms of the tongue base remains difficult despite recent advances in diagnostic ... of the hypoglossal nerve within the base of the tongue puts it at risk from invasion or compression from malignant neoplasms at ... malignant neoplasms may arise from these tissues. ...
... unspecified Hypopharyngeal wall NOS Hypopharynx NOS 149 Malignant neoplasm of other and ill-defined sites within the lip, oral ... Benign neoplasms 230-234 Carcinoma in situ 235-238 Neoplasms of uncertain behavior [see Note, page 140] 239 Neoplasms of ... MALIGNANT NEOPLASM OF GENITOURINARY ORGANS (179-189) 179 Malignant neoplasm of uterus, part unspecified 180 Malignant neoplasm ... 239 Neoplasms of unspecified nature Includes: "growth" NOS neoplasm NOS new growth NOS tumor NOS 239.0 Digestive system ...
Laryngeal Neoplasms, Mouth Neoplasms, Lip Neoplasms, Peposertib, Intensity-Modulated Radiation Therapy ... a study on Head and Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Hypopharyngeal Cancer Oropharyngeal Cancer Head and ... Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous ... Stage III Hypopharyngeal Carcinoma AJCC v8, Stage III Laryngeal Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8, ...
Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.2 Malignant neoplasm of posterior wall of hypopharynx ... Malignant neoplasm of scapula and long bones of right upper limb C40.02 Malignant neoplasm of scapula and long bones of left ... Other specified malignant neoplasm of skin of other parts of face C44.40 Unspecified malignant neoplasm of skin of scalp and ... Malignant neoplasm of overlapping sites of right eye and adnexa C69.82 Malignant neoplasm of overlapping sites of left eye and ...
Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect C13.2 Malignant neoplasm of posterior wall of hypopharynx ... Malignant neoplasm of overlapping sites of unspecified parts of mouth C06.89 Malignant neoplasm of overlapping sites of other ... Personal history of malignant neoplasm of larynx Z85.818 Personal history of malignant neoplasm of other sites of lip, oral ... Personal history of malignant neoplasm of unspecified site of lip, oral cavity, and pharynx ...
Hypopharyngeal Cancer , Laryngeal Cancer , Nasopharyngeal Cancer , Oral Cancer , Salivary Gland Cancer , Skull Base Tumors , ... genitourinary neoplasm. *gliomas. *gynecologic cancer. *hairy cell leukemia. *head and neck cancer ...
Hypopharyngeal Neoplasms. *Hypopharynx. *Illinois. *Immunoglobulin Light-chain Amyloidosis. *Immunohistochemistry. *Incidence. ...
"Pharyngeal Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Pharyngeal Neoplasms" by people in this website by year, and ... Below are the most recent publications written about "Pharyngeal Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Pharyngeal Neoplasms". ...
Gen General SurgeryNeo Neoplasms. Translation:Humans * Well-Differentiated Hypopharyngeal Liposarcoma-Associated Airway ...
Hypopharyngeal Neoplasms -- therapy : Treatment of esophageal and hypopharyngeal squamous cell carcinoma / Giovanni de Manzoni ... Hypopharynx -- Diverticula. : Management of Zenker and hypopharyngeal diverticula / Richard Scher, David Myssiorek, editors ...
  • Our objective was to evaluate recurrence patterns of hypopharyngeal and laryngeal carcinoma after chemoradiation and options for salvage surgery, with special emphasis on elderly patients. (nih.gov)
  • In a retrospective study all patients who underwent chemoradiation for hypopharyngeal and laryngeal carcinoma in a tertiary care academic center from 1990 through 2010 were evaluated. (nih.gov)
  • Treatment of esophageal and hypopharyngeal squamous cell carcinoma / Giovanni de Manzoni (ed. (edu.au)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)
  • There is an increased predisposition to hypopharyngeal and upper esophageal squamous cell carcinoma . (radiopaedia.org)
  • Midazolam significantly inhibited the growth and proliferation of FaDu human hypopharyngeal squamous cell carcinoma cells, concurring with the induction of G 0 /G 1 cell cycle arrest and blockage of Rb activation. (elsevierpure.com)
  • Midazolam significantly inhibited the growth and proliferation of FaDu human hypopharyngeal squamous cell carcinoma cells, concurring with the induction of G0/G1 cell cycle arrest and blockage of Rb activation. (elsevierpure.com)
  • Hypopharyngeal cancer is a term used for tumors of a subsite of the upper aerodigestive tract, and like most other subsite designations, the distinction is anatomic rather than pathophysiologic within the group of head and neck malignancies . (medscape.com)
  • High survivorship costs were associated with female sex, hypopharyngeal tumors, and treatment with multimodal therapy. (wustl.edu)
  • Hypopharyngeal cancers are often named for their location, including pyriform sinus, lateral pharyngeal wall, posterior pharyngeal wall, or postcricoid pharynx (see images below). (medscape.com)
  • As in other head and neck cancer sites, more than 95% of hypopharyngeal malignancies arise from the epithelium of the mucosa and, therefore, are squamous cell cancers. (medscape.com)
  • Of patients with hypopharyngeal cancers, 70% have stage III disease at presentation. (medscape.com)
  • Can Laryngeal and Hypopharyngeal Cancers Be Found Early? (medlineplus.gov)
  • Can Laryngeal and Hypopharyngeal Cancers Be Prevented? (medlineplus.gov)
  • In particular, high garlic use was associated with a significant risk reduction of overall HNC and oro/hypopharyngeal cancers by 26 and 38%, respectively. (mainlyplants.com)
  • The concept does not refer to neoplasms located in tissue composed of squamous elements. (lookformedical.com)
  • The clinical significance of cervical esophageal and hypopharyngeal webs. (radiopaedia.org)
  • The base of tongue is the site for the posterior opening of the oral cavity, the entrance of the pharynx and esophagus, and the inferior aspect of the nasopharynx .The surgical management of malignant neoplasms of the tongue base remains difficult despite recent advances in diagnostic techniques. (medscape.com)
  • The anatomic location of the hypoglossal nerve within the base of the tongue puts it at risk from invasion or compression from malignant neoplasms at the primary site or metastatic disease in the neck. (medscape.com)
  • Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g. (uky.edu)
  • Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII). (umassmed.edu)
  • The incidence of laryngeal cancer is 4-5 times that of hypopharyngeal cancer. (medscape.com)
  • A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. (elsevierpure.com)
  • The purpose of this study is to elucidate the association between PM 2.5 and oral neoplasm, including oral potentially malignant disorder (OPMD) and oral cancer (OC), taking into account the geographical heterogeneity. (aaqr.org)
  • The reemergence of a malignant head and neck neoplasm after a period of remission. (nih.gov)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment? (medlineplus.gov)
  • In a retrospective cohort study, Kuo et al reported a decline in the incidence of hypopharyngeal cancer in the United States by an average of -2.0% annually between 1973 and 2010. (medscape.com)
  • Scientists conclude, although the most effective strategy for HNC prevention involves alcohol and tobacco control, selected dietary advices, including a vegetables rich diet, specifically with a high allium vegetables intake, may reduce the occurrence of this neoplasm with high incidence and low survival. (mainlyplants.com)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • Patients diagnosed with hypopharyngeal cancer are typically men aged 55-70 years with a history of tobacco use and/or alcohol ingestion. (medscape.com)
  • It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer. (lookformedical.com)
  • The aforementioned study by Kuo and colleagues found that the 5-year overall survival rate for hypopharyngeal cancer rose significantly from 1988-1990 and from 1991-1995 but that no significant changes in survival rate could be demonstrated for other years. (medscape.com)
  • A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. (lookformedical.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • 3. Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study. (nih.gov)
  • 4. Clinical significance of intensive endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma. (nih.gov)
  • The clinicopathological features of GRP78/BiP expression in patients with advanced hypopharyngeal squamous cell carcinoma (HSCC) remain unclear. (elis.sk)
  • Squamous cell carcinoma is the most common malignant neoplasm affecting this region and early diagnosis has an important role in treatment outcome. (bvsalud.org)
  • Objectives: This study aims to evaluate whether patients with hypopharyngeal and/or laryngeal squamous cell carcinoma (SCC) who underwent organ preservation therapy (OPT) present at the time of relapse some factor that determines the local recurrence of the disease. (bvsalud.org)
  • Hypopharyngeal cancer is a term used for tumors of a subsite of the upper aerodigestive tract, and like most other subsite designations, the distinction is anatomic rather than pathophysiologic within the group of head and neck malignancies . (medscape.com)
  • As in other head and neck cancer sites, more than 95% of hypopharyngeal malignancies arise from the epithelium of the mucosa and, therefore, are squamous cell cancers. (medscape.com)
  • Current practice standards for the treatment of early to moderately advanced laryngeal and hypopharyngeal cancer demand both achievement of cure and preservation of laryngeal structure and function to the greatest extent possible. (nih.gov)
  • Twenty-five patients suffering from primary hypopharyngeal cancer were treated between 1990 and 1992. (who.int)
  • Several studies have investigated hypopharyngeal cancer (HC) risk in combination with xenobiotic metabolism-related genetic polymorphisms and the burden of alcohol consumption and smoking in European countries but not in East Asian countries. (nih.gov)
  • 12. Impact of the early detection of esophageal neoplasms in hypopharyngeal cancer patients treated with concurrent chemoradiotherapy. (nih.gov)
  • The response rate to ICHT for larynx cancer was 69.6% (7.1% complete, 62.5% partial response) and for hypopharyngeal cancer was 84.3% (6.9% complete, 77.4% partial response). (mcmaster.ca)
  • The incidence of laryngeal cancer is 4-5 times that of hypopharyngeal cancer. (medscape.com)
  • In a retrospective cohort study, Kuo et al reported a decline in the incidence of hypopharyngeal cancer in the United States by an average of -2.0% annually between 1973 and 2010. (medscape.com)
  • A study by Jakobsen et al found that between 1980 and 2014, the age-adjusted incidence rate for hypopharyngeal cancer in Denmark rose from 0.3 per 100,000 to 1.1 per 100,000 (a 4.1% per year increase). (medscape.com)
  • Patients diagnosed with hypopharyngeal cancer are typically men aged 55-70 years with a history of tobacco use and/or alcohol ingestion. (medscape.com)
  • The aforementioned study by Kuo and colleagues found that the 5-year overall survival rate for hypopharyngeal cancer rose significantly from 1988-1990 and from 1991-1995 but that no significant changes in survival rate could be demonstrated for other years. (medscape.com)
  • Traditionally, operable hypopharyngeal cancer has been treated by total (occasionally partial) laryngectomy and partial or circumferential pharyngectomy, followed by reconstruction and postoperative radiotherapy in most cases. (elsevierpure.com)
  • Efforts to preserve speech and swallowing function in the surgical treatment of hypopharyngeal (and laryngeal) cancer have resulted in a declining use of total laryngopharyngectomy and improved reconstructive efforts, including microvascular free tissue transfer. (elsevierpure.com)
  • In this article, several aspects of surgical and nonsurgical approaches in the treatment of hypopharyngeal cancer are discussed. (elsevierpure.com)
  • What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment? (medlineplus.gov)
  • A male patient in his 60s was diagnosed with right hypopharyngeal cancer. (amjcaserep.com)
  • The melanoma was discovered during a 2-year followup after treatment for hypopharyngeal cancer and esophageal melanosis, leading to surgery. (amjcaserep.com)
  • Histological evidence of metastatic involvement of paratracheal lymph nodes in hypopharyngeal carcinoma and its clinicopathological implications were studied. (who.int)
  • We have prospectively analyzed the prevalence and distribution of histologic cervical node metastases in laryngeal and hypopharyngeal squamous carcinoma to determine the most appropriate form of neck dissection. (nih.gov)
  • We have examined specimens from 100 consecutive patients in whom neck dissection was part of the primary treatment of laryngeal and hypopharyngeal carcinoma. (nih.gov)
  • Our results support the use of elective dissection of node levels II to IV for N0 laryngeal and hypopharyngeal carcinoma. (nih.gov)
  • Twenty-five patients with hypopharyngeal carcinoma underwent total laryngopharyngo-oesophagectomy with complete paratracheal clearance. (who.int)
  • The incidence of metastatic involvement of the PTNs in patients with hypopharyngeal carcinoma, as well as the clinicopathological factors associated with their metastases are not adequately documented. (who.int)
  • The present study aimed to evaluate the clinicopathological characteristics of primary hypopharyngeal carcinoma and neck secondaries, which are associated with PTN metastases. (who.int)
  • We describe a hypopharyngeal basosquamous carcinoma that became large with only subtle symptoms before causing the patient's sudden and unexpected death. (medscape.com)
  • Acinic Cell Carcinoma A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
  • Som [4] emphasized the importance of removing these nodes when attempting radical resection of pharyngo-oesophageal neoplasms and advocated dissection of the lymph nodes lying above the innominate vein in the superior mediastinum. (who.int)
  • Amongst them, pediatric cancers and rare hematologic neoplasms are often covered by dedicated educational events, while rare adult solid cancers are hardly grouped together and approached as a collective group of neoplasms. (eso.net)
  • The incidence of positive paratracheal lymph nodes was 40% in hypopharyngeal tumours. (who.int)
  • Excluding laryngeal papillomas, neoplasms of the hypopharynx rarely cause sudden asphyxial death in adults. (medscape.com)
  • Code Preferred Term Synonyms Definition Neoplastic Status C7419 Acanthoma A benign skin neoplasm composed of epithelial cells. (nih.gov)
  • In the United States and Canada, 65-85% of hypopharyngeal carcinomas involve the pyriform sinuses, 10-20% involve the posterior pharyngeal wall, and 5-15% involve the postcricoid area. (medscape.com)
  • Bochtler T, Löffler H, Krämer A. Diagnosis and management of metastatic neoplasms with unknown primary. (cancer.org)
  • The hypopharyngeal lymph usually flows directly into the superior nodes of the deep cervical chain. (who.int)
  • Imaging of Hypopharyngeal & Cervical Esophageal Pathology. (acoredu.com)
  • A high clinical index of suspicion and early laryngoscopy in individuals with symptoms suggestive of hypopharyngeal neoplasia are important. (medscape.com)
  • Translationeel onderzoek ten bate van gezondheidszorg voor gehoorgestoorden: Van oorzakelijke studies tot bewustwordingscampagnes en implementatie van technologische verbeteringen zoals beeldgenavigeerd en robot-geassiteerde chirurgie. (vub.be)