A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Sensation of discomfort, distress, or agony in the abdominal region.
A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
A characteristic symptom complex.
The normal process of elimination of fecal material from the RECTUM.
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
A state of increased receptivity to suggestion and direction, initially induced by the influence of another person.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
The motor activity of the GASTROINTESTINAL TRACT.
Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.
Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
The sensory fibers innervating the viscera.
Impaired digestion, especially after eating.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
The act of dilating.
A segment of the COLON between the RECTUM and the descending colon.
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
Amount of stimulation required before the sensation of pain is experienced.
The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Methods and procedures for the diagnosis of diseases or dysfunction of the digestive system or its organs or demonstration of their physiological processes.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
Measurement of the pressure or tension of liquids or gases with a manometer.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A subclass of serotonin receptors that form cation channels and mediate signal transduction by depolarizing the cell membrane. The cation channels are formed from 5 receptor subunits. When stimulated the receptors allow the selective passage of SODIUM; POTASSIUM; and CALCIUM.
Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Contractions of the abdominal muscles upon stimulation of the skin (superficial abdominal reflex) or tapping neighboring bony structures (deep abdominal reflex). The superficial reflex may be weak or absent, for example, after a stroke, a sign of upper (suprasegmental) motor neuron lesions. (Stedman, 25th ed & Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p1073)
Any tests done on exhaled air.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
The use of mind to cure disease, particularly physical illness.
Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A group of disorders characterized by physical symptoms that are affected by emotional factors and involve a single organ system, usually under AUTONOMIC NERVOUS SYSTEM control. (American Psychiatric Glossary, 1988)
A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.
A subtype of G-protein-coupled SEROTONIN receptors that preferentially couple to GS STIMULATORY G-PROTEINS resulting in increased intracellular CYCLIC AMP. Several isoforms of the receptor exist due to ALTERNATIVE SPLICING of its mRNA.
A mental disorder characterized by chronic fatigue and concomitant physiologic symptoms.
Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Stress wherein emotional factors predominate.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)
The segment of LARGE INTESTINE between the CECUM and the TRANSVERSE COLON. It passes cephalad from the cecum to the caudal surface of the right lobe of the LIVER where it bends sharply to the left, forming the right colic flexure.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.
Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.
Agents that are used to stimulate evacuation of the bowels.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A group of ANTI-BACTERIAL AGENTS characterized by a chromophoric naphthohydroquinone group spanned by an aliphatic bridge not previously found in other known ANTI-BACTERIAL AGENTS. They have been isolated from fermentation broths of Streptomyces mediterranei.
Infections with organisms of the genus BLASTOCYSTIS. The species B. hominis is responsible for most infections. Parasitologic surveys have generally found small numbers of this species in human stools, but higher positivity rates and organism numbers in AIDS patients and other immunosuppressed patients (IMMUNOCOMPROMISED HOST). Symptoms include ABDOMINAL PAIN; DIARRHEA; CONSTIPATION; VOMITING; and FATIGUE.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring.
A rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA. It inhabits the intestines and feces of humans as well as the human vagina.
The seeking and acceptance by patients of health service.
A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
A pouch or sac developed from a tubular or saccular organ, such as the GASTROINTESTINAL TRACT.
Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
A major orthodox system of Hindu philosophy based on Sankhya (metaphysical dualism) but differing from it in being theistic and characterized by the teaching of raja-yoga as a practical method of liberating the self. It includes a system of exercises for attaining bodily or mental control and well-being with liberation of the self and union with the universal spirit. (From Webster, 3d ed)
Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.
Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.
A genus of protozoa of the suborder BLASTOCYSTINA. It was first classified as a yeast but further studies have shown it to be a protozoan.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.
Treatment methods or techniques which are based on the knowledge of mind and body interactions. These techniques can be used to reduce the feeling of tension and effect of stress, and to enhance the physiological and psychological well-being of an individual.
The evacuation of food from the stomach into the duodenum.
Costs which are directly identifiable with a particular service.
Use of plants or herbs to treat diseases or to alleviate pain.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
A system of therapeutics founded by Samuel Hahnemann (1755-1843), based on the Law of Similars where "like cures like". Diseases are treated by highly diluted substances that cause, in healthy persons, symptoms like those of the disease to be treated.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (PHYSICAL THERAPY MODALITIES; DIET; ACUPUNCTURE) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment.
That portion of the body that lies between the THORAX and the PELVIS.
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
The process by which PAIN is recognized and interpreted by the brain.

Activated mast cells infiltrate in close proximity to enteric nerves in diarrhea-predominant irritable bowel syndrome. (1/865)

Mast cells (MC) may be one factor influencing the response of visceral afferent nerves to mechanical and chemical stimuli. The aim of this study was to evaluate the degree of infiltration and activity of colonic MC in irritable bowel syndrome (IBS). Biopsy specimens were obtained from the cecum and rectum of 14 diarrhea predominant IBS and 14 normal controls. Electron microscopy was used to determine the number of intact and degranulated colonic MC and to quantify these separately according to the distance between MC and enteric nerves. An increased number of MC in both cecum and rectum in the IBS group in comparison with the control group was demonstrated (p<0.05). Activated MC in close proximity to enteric nerves were significantly increased in both cecum and rectum of the IBS group compared to control group (p<0.005). In addition, activated MC were significantly increased in close proximity to the nerves compared to those in the remote area in both cecum and rectum of the IBS group (p<0.0001). MC were significantly increased and activated in both cecum and rectum of the IBS group compared to controls. MC may play a role in the gut sensory hypersensitivity of IBS.  (+info)

Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics. (2/865)

BACKGROUND: Various causes of malabsorption syndrome (MAS) are associated with intestinal stasis that may cause small intestinal bacterial overgrowth (SIBO). Frequency, nature and antibiotic sensitivity of SIBO in patients with MAS are not well understood. METHODS: Jejunal aspirates of 50 consecutive patients with MAS were cultured for bacteria and colony counts and antibiotic sensitivity were performed. Twelve patients with irritable bowel syndrome were studied as controls. RESULTS: Culture revealed growth of bacteria in 34/50 (68%) patients with MAS and 3/12 controls (p < 0.05). Colony counts ranged from 3 x 10(2) to 10(15) (median 10(5)) in MAS and 100 to 1000 (median 700) CFU/ml in controls (p 0.003). 21/50 (42%) patients had counts GreaterEqual;105 CFU/ml in MAS and none of controls (p < 0.05). Aerobes were isolated in 34/34 and anaerobe in 1/34. Commonest Gram positive and negative bacteria were Streptococcus species and Escherichia coli respectively. The isolated bacteria were more often sensitive to quinolones than to tetracycline (ciprofloxacin: 39/47 and norfloxacin: 34/47 vs. tetracycline 19/47, <0.01), ampicillin, erythromycin and co-trimoxazole (21/44, 14/22 and 24/47 respectively vs. tetracycline, p = ns). CONCLUSIONS: SIBO is common in patients with MAS due to various causes and quinolones may be the preferred treatment. This needs to be proved further by a randomized controlled trial.  (+info)

Systematic review: the economic impact of irritable bowel syndrome. (3/865)

BACKGROUND: Although little mortality is associated with irritable bowel syndrome, curative therapy does not exist and thus the economic impact of this disorder may be considerable. METHODS: A systematic review of the literature was performed. Studies were included if their focus was irritable bowel syndrome, and direct and/or productivity (indirect) costs were reported. Two investigators abstracted the data independently. RESULTS: One hundred and seventy-four studies were retrieved by the search; 11 fulfilled all criteria for entry into the review. The mean direct costs of irritable bowel syndrome management were reported to be UK pound sterling90, Canadian$259 and US$619 per patient annually, with total annual direct costs related to irritable bowel syndrome of pound sterling45.6 million (UK) and $1.35 billion (USA). Direct resource consumption of all health care for irritable bowel syndrome patients ranged from US$742 to US$3166. Productivity costs ranged from US$335 to US$748, with total annual costs of $205 million estimated in the USA. Annual expenditure for all health care, in addition to expenditure limited to gastrointestinal disorders, was significantly higher in irritable bowel syndrome patients than in control populations. CONCLUSIONS: Despite the lack of significant mortality, irritable bowel syndrome is associated with high direct and productivity costs. Irritable bowel syndrome patients consume more gastrointestinal-related and more total health care resources than non-irritable bowel syndrome controls, and sustain significantly greater productivity losses.  (+info)

Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. (4/865)

Expression of a distant homologue MHC class I molecule, MHC class I-related chain A (MICA), has been found to be stress inducible and limited to the intestinal epithelium. This nonclassical MHC molecule is associated with various carcinomas in humans. To understand the biological consequences of MICA expression in the gut, we generated transgenic (Tg) mice (T3(b)-MICA Tg) under the control of the T3(b) promoter. The T3(b)-MICA Tg mice expressed MICA selectively in the intestine and had an increased number of TCRalphabeta CD4CD8alphaalpha, double-positive (DP) intraepithelial lymphocytes (IELs) in the small bowel. These MICA-expanded DP IELs exhibited a bias to Vbeta8.2 and overlapped motifs of the complementarity-determining region 3 region among various Tg mice. Hence, the overexpression of MICA resulted in a clonal expansion of DP IELs. Studies in model of inflammatory bowel disease showed that transgenic MICA was able to attenuate the acute colitis induced by dextran sodium sulfate administration. Therefore, this unique in vivo model will enable investigation of possible influences of stress-inducible MICA on the gut immune surveillance.  (+info)

Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. (5/865)

A newly identified costimulatory molecule, programmed death-1 (PD-1), provides a negative signal that is essential for immune homeostasis. However, it has been suggested that its ligands, B7-H1 (PD-L1) and B7-dendritic cells (B7-DC; PD-L2), could also costimulate T cell proliferation and cytokine secretion. Here we demonstrate the involvement of PD-1/B7-H1 and B7-DC interaction in the development of colitis. We first examined the expression profiles of PD-1 and its ligands in both human inflammatory bowel disease and a murine chronic colitis model induced by adoptive transfer of CD4(+)CD45RB(high) T cells to SCID mice. Second, we assessed the therapeutic potential of neutralizing anti-B7-H1 and/or B7-DC mAbs using this colitis model. We found significantly increased expression of PD-1 on T cells and of B7-H1 on T, B, and macrophage/DCs in inflamed colon from both inflammatory bowel disease patients and colitic mice. Unexpectedly, the administration of anti-B7-H1, but not anti-B7-DC, mAb after transfer of CD4(+)CD45RB(high) T cells suppressed wasting disease with colitis, abrogated leukocyte infiltration, and reduced the production of IFN-gamma, IL-2, and TNF-alpha, but not IL-4 or IL-10, by lamina propria CD4(+) T cells. These data suggest that the interaction of PD-1/B7-H1, but not PD-1/B7-DC, might be involved in intestinal mucosal inflammation and also show a possible role of interaction between B7-H1 and an as yet unidentified receptor for B7-H1 in inducing T cell activation.  (+info)

Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome. (6/865)

AIM: Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy. METHODS: One hundred IBS patients (F:M=73:27, age 48+/-2 years, mean+/-SE) fulfilling ROME II criteria matched with 100 healthy subjects (F:M=70:30, 45+/-2 years). Dyspepsia, bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT) were measured respectively by ultrasonography and H(2)-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue scales. RESULTS: Compared with controls, IBS patients had increased dyspepsia (score 12.6+/-0.7 vs 5.1+/-0.2, P<0.0001), weekly bowel movements (12.3+/-0.4 vs 5.5+/-0.2, P<0.00001, comparable stool shape), alexithymia (score 59.1+/-1.1 vs 40.5+/-1.0, P=0.001), poor quality of life and psycho-affective profile. IBS patients had normal gallbladder emptying, but delayed gastric emptying (T50: 35.5+/-1.0 vs 26.1+/-0.6 min, P=0.00001) and OCTT (163.0+/-5.4 vs 96.6+/-1.8 min, P=0.00001). Fullness, nausea, and epigastric pain/discomfort were greater in IBS than in controls. CONCLUSION: ROME II IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life. The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recovered after therapy.  (+info)

Cluster analysis of symptoms and health seeking behaviour differentiates subgroups of patients with severe irritable bowel syndrome. (7/865)

BACKGROUND: Irritable bowel syndrome (IBS) is a heterogeneous condition which is diagnosed according to specific bowel symptom clusters. The aim of the present study was to identify subgroups of IBS subjects using measures of rectal sensitivity and psychological symptoms, in addition to bowel symptoms. Such groupings, which cross conventional diagnostic approaches, may provide greater understanding of the pathogenesis of the condition and its treatment. METHOD: A K means cluster analysis was used to group 107 clinic patients with IBS according to physiological, physical, and psychological parameters. All patients had severe IBS and had failed to respond to usual medical treatment. Twenty nine patients had diarrhoea predominant IBS, 26 constipation predominant, and 52 had an alternating bowel habit. RESULTS: The clusters were most clearly delineated by two variables: "rectal perceptual threshold (volume)" and "number of doctor visits". Three subgroups were formed. Group I comprised patients with low distension thresholds and high rates of psychiatric morbidity, doctor consultations, interpersonal problems, and sexual abuse. Group II also had low distension thresholds but low rates of childhood abuse and moderate levels of psychiatric disorders. Group III had high distension thresholds, constipation or alternating IBS, and low rates of medical consultations and sexual abuse. CONCLUSION: The marked differences across the three groups suggest that each may have a different pathogenesis and respond to different treatment approaches. Inclusion of psychosocial factors in the analysis enabled more clinically meaningful groups to be identified than those traditionally determined by bowel symptoms alone or rectal threshold.  (+info)

Long term benefits of hypnotherapy for irritable bowel syndrome. (8/865)

BACKGROUND AND AIMS: There is now good evidence from several sources that hypnotherapy can relieve the symptoms of irritable bowel syndrome in the short term. However, there is no long term data on its benefits and this information is essential before the technique can be widely recommended. This study aimed to answer this question. PATIENTS AND METHODS: 204 patients prospectively completed questionnaires scoring symptoms, quality of life, anxiety, and depression before, immediately after, and up to six years following hypnotherapy. All subjects also subjectively assessed the effects of hypnotherapy retrospectively in order to define their "responder status". RESULTS: 71% of patients initially responded to therapy. Of these, 81% maintained their improvement over time while the majority of the remaining 19% claimed that deterioration of symptoms had only been slight. With respect to symptom scores, all items at follow up were significantly improved on pre-hypnotherapy levels (p<0.001) and showed little change from post-hypnotherapy values. There were no significant differences in the symptom scores between patients assessed at 1, 2, 3, 4, or 5+ years following treatment. Quality of life and anxiety or depression scores were similarly still significantly improved at follow up (p<0.001) but did show some deterioration. Patients also reported a reduction in consultation rates and medication use following the completion of hypnotherapy. CONCLUSION: This study demonstrates that the beneficial effects of hypnotherapy appear to last at least five years. Thus it is a viable therapeutic option for the treatment of irritable bowel syndrome.  (+info)

Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain, bloating, and altered bowel habits in the absence of any structural or biochemical abnormalities. The symptoms can vary from person to person, ranging from mild to severe.

The exact cause of IBS is not known, but it's thought to involve a combination of factors such as muscle contractions in the intestine, abnormalities in the nervous system, inflammation in the intestines, severe infection, or changes in bacteria in the gut.

It's important to note that while IBS can cause great discomfort and distress, it does not lead to serious complications such as changes in bowel tissue or increased risk of colorectal cancer. However, it can significantly affect a person's quality of life and daily activities.

Functional colonic diseases are a group of disorders of the large intestine (colon) that do not have a structural or biochemical explanation. They are characterized by chronic and often intermittent symptoms, such as abdominal pain, bloating, and changes in bowel habits, but do not show any visible abnormalities or damage to the tissue of the colon during routine examination or testing.

The most common functional colonic diseases include:

1. Irritable Bowel Syndrome (IBS): A disorder characterized by recurrent abdominal pain, bloating, and changes in bowel habits, such as constipation or diarrhea.
2. Functional Constipation: A condition where a person experiences difficult or infrequent bowel movements, but there is no obvious structural or biochemical cause.
3. Functional Diarrhea: A disorder characterized by frequent loose stools, but without any underlying structural or biochemical abnormalities.
4. Abdominal Bloating: A condition where the belly feels full and tight, often accompanied by discomfort or pain, but without any visible distention.
5. Functional Abdominal Pain Syndrome: A disorder characterized by chronic or recurrent abdominal pain that is not associated with any structural or biochemical abnormalities.

The exact cause of functional colonic diseases is unknown, but they are believed to be related to a combination of factors, including genetics, environmental factors, altered gut motility, visceral hypersensitivity, and psychological factors such as stress and anxiety. Treatment typically involves lifestyle modifications, such as changes in diet and exercise, and medication to manage symptoms.

Constipation is a condition characterized by infrequent bowel movements or difficulty in passing stools that are often hard and dry. The medical definition of constipation varies, but it is generally defined as having fewer than three bowel movements in a week. In addition to infrequent bowel movements, other symptoms of constipation can include straining during bowel movements, feeling like you haven't completely evacuated your bowels, and experiencing hard or lumpy stools.

Constipation can have many causes, including a low-fiber diet, dehydration, certain medications, lack of physical activity, and underlying medical conditions such as irritable bowel syndrome or hypothyroidism. In most cases, constipation can be treated with lifestyle changes, such as increasing fiber intake, drinking more water, and getting regular exercise. However, if constipation is severe, persistent, or accompanied by other symptoms, it's important to seek medical attention to rule out any underlying conditions that may require treatment.

Abdominal pain is defined as discomfort or painful sensation in the abdomen. The abdomen is the region of the body between the chest and the pelvis, and contains many important organs such as the stomach, small intestine, large intestine, liver, gallbladder, pancreas, and spleen. Abdominal pain can vary in intensity from mild to severe, and can be acute or chronic depending on the underlying cause.

Abdominal pain can have many different causes, ranging from benign conditions such as gastritis, indigestion, or constipation, to more serious conditions such as appendicitis, inflammatory bowel disease, or abdominal aortic aneurysm. The location, quality, and duration of the pain can provide important clues about its cause. For example, sharp, localized pain in the lower right quadrant of the abdomen may indicate appendicitis, while crampy, diffuse pain in the lower abdomen may suggest irritable bowel syndrome.

It is important to seek medical attention if you experience severe or persistent abdominal pain, especially if it is accompanied by other symptoms such as fever, vomiting, or bloody stools. A thorough physical examination, including a careful history and a focused abdominal exam, can help diagnose the underlying cause of the pain and guide appropriate treatment.

Short Bowel Syndrome (SBS) is a malabsorption disorder that occurs when a significant portion of the small intestine has been removed or is functionally lost due to surgical resection, congenital abnormalities, or other diseases. The condition is characterized by an inability to absorb sufficient nutrients, water, and electrolytes from food, leading to diarrhea, malnutrition, dehydration, and weight loss.

The small intestine plays a crucial role in digestion and absorption of nutrients, and when more than 50% of its length is affected, the body's ability to absorb essential nutrients becomes compromised. The severity of SBS depends on the extent of the remaining small intestine, the presence or absence of the ileocecal valve (a sphincter that separates the small and large intestines), and the functionality of the residual intestinal segments.

Symptoms of Short Bowel Syndrome include:

1. Chronic diarrhea
2. Steatorrhea (fatty stools)
3. Dehydration
4. Weight loss
5. Fat-soluble vitamin deficiencies (A, D, E, and K)
6. Electrolyte imbalances
7. Malnutrition
8. Anemia
9. Bacterial overgrowth in the small intestine
10. Osteoporosis due to calcium and vitamin D deficiencies

Treatment for Short Bowel Syndrome typically involves a combination of nutritional support, medication, and sometimes surgical interventions. Nutritional management includes oral or enteral feeding with specially formulated elemental or semi-elemental diets, as well as parenteral nutrition (intravenous feeding) to provide essential nutrients that cannot be absorbed through the gastrointestinal tract. Medications such as antidiarrheals, H2 blockers, proton pump inhibitors, and antibiotics may also be used to manage symptoms and prevent complications. In some cases, intestinal transplantation might be considered for severe SBS patients who do not respond to other treatments.

Gastrointestinal agents are a class of pharmaceutical drugs that affect the gastrointestinal (GI) tract, which includes the organs involved in digestion such as the mouth, esophagus, stomach, small intestine, large intestine, and anus. These agents can have various effects on the GI tract, including:

1. Increasing gastric motility (promoting bowel movements) - laxatives, prokinetics
2. Decreasing gastric motility (reducing bowel movements) - antidiarrheal agents
3. Neutralizing gastric acid - antacids
4. Reducing gastric acid secretion - H2-blockers, proton pump inhibitors
5. Protecting the mucosal lining of the GI tract - sucralfate, misoprostol
6. Relieving symptoms associated with GI disorders such as bloating, abdominal pain, and nausea - antispasmodics, antiemetics

Examples of gastrointestinal agents include:

* Laxatives (e.g., psyllium, docusate)
* Prokinetics (e.g., metoclopramide)
* Antacids (e.g., calcium carbonate, aluminum hydroxide)
* H2-blockers (e.g., ranitidine, famotidine)
* Proton pump inhibitors (e.g., omeprazole, lansoprazole)
* Sucralfate
* Misoprostol
* Antispasmodics (e.g., hyoscyamine, dicyclomine)
* Antiemetics (e.g., ondansetron, promethazine)

It is important to note that gastrointestinal agents can have both therapeutic and adverse effects, and their use should be based on a careful evaluation of the patient's condition and medical history.

A syndrome, in medical terms, is a set of symptoms that collectively indicate or characterize a disease, disorder, or underlying pathological process. It's essentially a collection of signs and/or symptoms that frequently occur together and can suggest a particular cause or condition, even though the exact physiological mechanisms might not be fully understood.

For example, Down syndrome is characterized by specific physical features, cognitive delays, and other developmental issues resulting from an extra copy of chromosome 21. Similarly, metabolic syndromes like diabetes mellitus type 2 involve a group of risk factors such as obesity, high blood pressure, high blood sugar, and abnormal cholesterol or triglyceride levels that collectively increase the risk of heart disease, stroke, and diabetes.

It's important to note that a syndrome is not a specific diagnosis; rather, it's a pattern of symptoms that can help guide further diagnostic evaluation and management.

Defecation is the medical term for the act of passing stools (feces) through the anus. It is a normal bodily function that involves the contraction of muscles in the colon and anal sphincter to release waste from the body. Defecation is usually a regular and daily occurrence, with the frequency varying from person to person.

The stool is made up of undigested food, bacteria, and other waste products that are eliminated from the body through the rectum and anus. The process of defecation is controlled by the autonomic nervous system, which regulates involuntary bodily functions such as heart rate and digestion.

Difficulties with defecation can occur due to various medical conditions, including constipation, irritable bowel syndrome, and inflammatory bowel disease. These conditions can cause symptoms such as hard or painful stools, straining during bowel movements, and a feeling of incomplete evacuation. If you are experiencing any problems with defecation, it is important to speak with your healthcare provider for proper diagnosis and treatment.

Gastrointestinal transit refers to the movement of food, digestive secretions, and waste products through the gastrointestinal tract, from the mouth to the anus. This process involves several muscles and nerves that work together to propel the contents through the stomach, small intestine, large intestine, and rectum.

The transit time can vary depending on factors such as the type and amount of food consumed, hydration levels, and overall health. Abnormalities in gastrointestinal transit can lead to various conditions, including constipation, diarrhea, and malabsorption. Therefore, maintaining normal gastrointestinal transit is essential for proper digestion, nutrient absorption, and overall health.

Diarrhea is a condition in which an individual experiences loose, watery stools frequently, often exceeding three times a day. It can be acute, lasting for several days, or chronic, persisting for weeks or even months. Diarrhea can result from various factors, including viral, bacterial, or parasitic infections, food intolerances, medications, and underlying medical conditions such as inflammatory bowel disease or irritable bowel syndrome. Dehydration is a potential complication of diarrhea, particularly in severe cases or in vulnerable populations like young children and the elderly.

Hypnosis is a state of highly focused attention or concentration, often associated with relaxation, and heightened suggestibility. In a clinical context, hypnosis is often used as a tool in hypnotherapy, to help individuals explore unconscious thoughts, feelings, and behaviors, or to make positive changes to their thoughts, behavior, and physical well-being. It's important to note that hypnosis is not a state of unconsciousness or sleep, but rather a state of altered consciousness characterized by increased suggestibility and focused attention.

It's also worth noting that the definition of hypnosis can vary between different fields and perspectives. Some definitions emphasize the role of suggestion in shaping experience during hypnosis, while others focus on the importance of expectancy and belief. Additionally, there is ongoing debate about the precise mechanisms underlying hypnotic phenomena, with some researchers emphasizing social and psychological factors, while others highlight neurological and physiological changes associated with hypnosis.

The rectum is the lower end of the digestive tract, located between the sigmoid colon and the anus. It serves as a storage area for feces before they are eliminated from the body. The rectum is about 12 cm long in adults and is surrounded by layers of muscle that help control defecation. The mucous membrane lining the rectum allows for the detection of stool, which triggers the reflex to have a bowel movement.

Gastrointestinal motility refers to the coordinated muscular contractions and relaxations that propel food, digestive enzymes, and waste products through the gastrointestinal tract. This process involves the movement of food from the mouth through the esophagus into the stomach, where it is mixed with digestive enzymes and acids to break down food particles.

The contents are then emptied into the small intestine, where nutrients are absorbed, and the remaining waste products are moved into the large intestine for further absorption of water and electrolytes and eventual elimination through the rectum and anus.

Gastrointestinal motility is controlled by a complex interplay between the autonomic nervous system, hormones, and local reflexes. Abnormalities in gastrointestinal motility can lead to various symptoms such as bloating, abdominal pain, nausea, vomiting, diarrhea, or constipation.

Flatulence is the medical term for the release of intestinal gas from the rectum, commonly known as passing gas or farting. It is a normal bodily function that occurs when the body digests food in the stomach and intestines.

During digestion, the body breaks down food into nutrients that can be absorbed into the bloodstream. However, not all food particles can be fully broken down, and some of them reach the large intestine, where they are fermented by bacteria. This fermentation process produces gases such as nitrogen, oxygen, carbon dioxide, hydrogen, and methane.

The buildup of these gases in the digestive tract can cause discomfort, bloating, and the urge to pass gas. The average person passes gas about 10-20 times a day, although this can vary widely from person to person.

While flatulence is a normal bodily function, excessive or frequent passing of gas can be a sign of an underlying digestive issue such as irritable bowel syndrome (IBS), lactose intolerance, or gastrointestinal infections. If you are experiencing persistent or severe symptoms, it is recommended to consult with a healthcare professional for further evaluation and treatment.

Visceral pain is a type of pain that originates from the internal organs (viscera) such as the stomach, intestines, liver, or heart. It's often described as diffuse, dull, and hard to localize, unlike somatic pain which arises from the skin, muscles, or bones and is usually easier to pinpoint.

Visceral pain may be caused by various conditions like inflammation, infection, ischemia (reduced blood supply), distention or stretching of the organ walls, or direct damage to the organs. The sensation of visceral pain can be modulated and referred to other areas of the body due to the complex interactions in the nervous system, making it sometimes challenging to diagnose the exact source of the pain.

Antidiarrheals are a class of medications that are used to treat diarrhea. They work by either slowing down the movement of the gut or increasing the absorption of water and electrolytes in the intestines, which helps to thicken the stool and reduce the frequency of bowel movements.

Some common examples of antidiarrheal medications include loperamide (Imodium), diphenoxylate/atropine (Lomotil), and bismuth subsalicylate (Pepto-Bismol). These medications can be effective in managing acute diarrhea, but it's important to use them only as directed and for a limited period of time. Prolonged use or overuse of antidiarrheals can lead to serious side effects, such as constipation, dehydration, and dependence.

It's also worth noting that while antidiarrheals can help manage the symptoms of diarrhea, they do not address the underlying cause of the condition. If you have chronic or severe diarrhea, it's important to speak with a healthcare provider to determine the root cause and develop an appropriate treatment plan.

Inflammatory Bowel Diseases (IBD) are a group of chronic inflammatory conditions primarily affecting the gastrointestinal tract. The two main types of IBD are Crohn's disease and ulcerative colitis.

Crohn's disease can cause inflammation in any part of the digestive system, from the mouth to the anus, but it most commonly affects the lower part of the small intestine (the ileum) and/or the colon. The inflammation caused by Crohn's disease often spreads deep into the layers of affected bowel tissue.

Ulcerative colitis, on the other hand, is limited to the colon, specifically the innermost lining of the colon. It causes long-lasting inflammation and sores (ulcers) in the lining of the large intestine (colon) and rectum.

Symptoms can vary depending on the severity and location of inflammation but often include abdominal pain, diarrhea, fatigue, weight loss, and reduced appetite. IBD is not the same as irritable bowel syndrome (IBS), which is a functional gastrointestinal disorder.

The exact cause of IBD remains unknown, but it's thought to be a combination of genetic factors, an abnormal immune response, and environmental triggers. There is no cure for IBD, but treatments can help manage symptoms and reduce inflammation, potentially leading to long-term remission.

The colon, also known as the large intestine, is a part of the digestive system in humans and other vertebrates. It is an organ that eliminates waste from the body and is located between the small intestine and the rectum. The main function of the colon is to absorb water and electrolytes from digested food, forming and storing feces until they are eliminated through the anus.

The colon is divided into several regions, including the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum, and anus. The walls of the colon contain a layer of muscle that helps to move waste material through the organ by a process called peristalsis.

The inner surface of the colon is lined with mucous membrane, which secretes mucus to lubricate the passage of feces. The colon also contains a large population of bacteria, known as the gut microbiota, which play an important role in digestion and immunity.

Carbolines are a type of chemical compound that contain a carbazole or dibenzopyrrole structure. These compounds have a variety of uses, including as pharmaceuticals and dyes. Some carbolines have been studied for their potential medicinal properties, such as their ability to act as antioxidants or to inhibit the growth of certain types of cells. However, it is important to note that many carbolines are also known to be toxic and can cause harm if ingested or otherwise introduced into the body. As with any chemical compound, it is essential to use caution when handling carbolines and to follow all safety guidelines to minimize the risk of exposure.

Visceral afferents are specialized nerve fibers that carry sensory information from the internal organs (viscera) to the central nervous system. These afferent neurons detect and transmit information about various visceral stimuli, such as pain, temperature, touch, pressure, chemical changes, and the state of organ distension or fullness. The information they relay helps regulate physiological functions, including digestion, respiration, and cardiovascular activity, and contributes to the perception of bodily sensations and visceral pain. Visceral afferents are an essential component of the autonomic nervous system and have their cell bodies located in the dorsal root ganglia or nodose ganglia.

Dyspepsia is a medical term that refers to discomfort or pain in the upper abdomen, often accompanied by symptoms such as bloating, nausea, belching, and early satiety (feeling full quickly after starting to eat). It is also commonly known as indigestion. Dyspepsia can have many possible causes, including gastroesophageal reflux disease (GERD), peptic ulcers, gastritis, and functional dyspepsia (a condition in which there is no obvious structural or biochemical explanation for the symptoms). Treatment for dyspepsia depends on the underlying cause.

Parasympatholytics are a type of medication that blocks the action of the parasympathetic nervous system. The parasympathetic nervous system is responsible for the body's rest and digest response, which includes slowing the heart rate, increasing intestinal and glandular activity, and promoting urination and defecation.

Parasympatholytics work by selectively binding to muscarinic receptors, which are found in various organs throughout the body, including the heart, lungs, and digestive system. By blocking these receptors, parasympatholytics can cause a range of effects, such as an increased heart rate, decreased glandular secretions, and reduced intestinal motility.

Some common examples of parasympatholytics include atropine, scopolamine, and ipratropium. These medications are often used to treat conditions such as bradycardia (slow heart rate), excessive salivation, and gastrointestinal cramping or diarrhea. However, because they can have significant side effects, parasympatholytics are typically used only when necessary and under the close supervision of a healthcare provider.

Probiotics are defined by the World Health Organization (WHO) as "live microorganisms which when administered in adequate amounts confer a health benefit on the host." They are often referred to as "good" or "friendly" bacteria because they help keep your gut healthy. Probiotics are naturally found in certain foods such as fermented foods like yogurt, sauerkraut, and some cheeses, or they can be taken as dietary supplements.

The most common groups of probiotics are lactic acid bacteria (like Lactobacillus) and bifidobacteria. They can help restore the balance of bacteria in your gut when it's been disrupted by things like illness, medication (such as antibiotics), or poor diet. Probiotics have been studied for their potential benefits in a variety of health conditions, including digestive issues, skin conditions, and even mental health disorders, although more research is needed to fully understand their effects and optimal uses.

Gastrointestinal diseases refer to a group of conditions that affect the gastrointestinal (GI) tract, which includes the organs from the mouth to the anus, responsible for food digestion, absorption, and elimination of waste. These diseases can affect any part of the GI tract, causing various symptoms such as abdominal pain, bloating, diarrhea, constipation, nausea, vomiting, and weight loss.

Common gastrointestinal diseases include:

1. Gastroesophageal reflux disease (GERD) - a condition where stomach acid flows back into the esophagus, causing heartburn and other symptoms.
2. Peptic ulcers - sores that develop in the lining of the stomach or duodenum, often caused by bacterial infection or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).
3. Inflammatory bowel disease (IBD) - a group of chronic inflammatory conditions of the intestine, including Crohn's disease and ulcerative colitis.
4. Irritable bowel syndrome (IBS) - a functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits.
5. Celiac disease - an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine.
6. Diverticular disease - a condition that affects the colon, causing diverticula (small pouches) to form and potentially become inflamed or infected.
7. Constipation - a common gastrointestinal symptom characterized by infrequent bowel movements, hard stools, and difficulty passing stools.
8. Diarrhea - a common gastrointestinal symptom characterized by loose, watery stools and frequent bowel movements.
9. Food intolerances and allergies - adverse reactions to specific foods or food components that can cause various gastrointestinal symptoms.
10. Gastrointestinal infections - caused by bacteria, viruses, parasites, or fungi that can lead to a range of symptoms, including diarrhea, vomiting, and abdominal pain.

Dilation, also known as dilatation, refers to the process of expanding or enlarging a body passage or cavity. In medical terms, it typically refers to the widening of a bodily opening or hollow organ, allowing for increased flow or access. This can occur naturally, such as during childbirth when the cervix dilates to allow for the passage of a baby, or it can be induced through medical procedures or interventions.

For example, dilation of the pupils is a natural response to darkness or certain medications, while dilation of blood vessels is a common side effect of some drugs and can also occur in response to changes in temperature or emotional state. Dilation of the stomach or intestines may be necessary for medical procedures such as endoscopies or surgeries.

It's important to note that dilation can also refer to the abnormal enlargement of a body part, such as dilated cardiomyopathy, which refers to an enlarged and weakened heart muscle.

The sigmoid colon is a part of the large intestine that forms an "S"-shaped curve before it joins the rectum. It gets its name from its unique shape, which resembles the Greek letter sigma (σ). The main function of the sigmoid colon is to store stool temporarily and assist in the absorption of water and electrolytes from digestive waste before it is eliminated from the body.

Gastroenterology is a branch of medicine that deals with the study, diagnosis, management, and treatment of disorders and diseases of the digestive system, also known as the gastrointestinal (GI) tract. This includes the esophagus, stomach, small intestine, large intestine (colon), liver, pancreas, gallbladder, and bile ducts.

Physicians who specialize in this field are called gastroenterologists. They undergo extensive training in internal medicine and then complete a fellowship in gastroenterology, where they gain expertise in using various diagnostic techniques such as endoscopy, colonoscopy, and radiologic imaging to evaluate GI tract disorders.

Gastroenterologists treat a wide range of conditions affecting the digestive system, including but not limited to:

1. Gastroesophageal reflux disease (GERD)
2. Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis
3. Irritable bowel syndrome (IBS)
4. Celiac disease
5. Hepatitis and other liver diseases
6. Pancreatic disorders, such as pancreatitis
7. Gastrointestinal cancers, like colon, rectal, and esophageal cancer
8. Functional gastrointestinal disorders (FGIDs), which include chronic abdominal pain, bloating, and difficulty with bowel movements

By focusing on the prevention, diagnosis, and treatment of digestive diseases, gastroenterologists play a crucial role in maintaining overall health and well-being for their patients.

Viscera is a medical term that refers to the internal organs of the body, specifically those contained within the chest and abdominal cavities. These include the heart, lungs, liver, pancreas, spleen, kidneys, and intestines. In some contexts, it may also refer to the reproductive organs. The term viscera is often used in anatomical or surgical descriptions, and is derived from the Latin word "viscus," meaning "an internal organ."

Pain threshold is a term used in medicine and research to describe the point at which a stimulus begins to be perceived as painful. It is an individual's subjective response and can vary from person to person based on factors such as their pain tolerance, mood, expectations, and cultural background.

The pain threshold is typically determined through a series of tests where gradually increasing levels of stimuli are applied until the individual reports feeling pain. This is often used in research settings to study pain perception and analgesic efficacy. However, it's important to note that the pain threshold should not be confused with pain tolerance, which refers to the maximum level of pain a person can endure.

In medical terms, sensation refers to the ability to perceive and interpret various stimuli from our environment through specialized receptor cells located throughout the body. These receptors convert physical stimuli such as light, sound, temperature, pressure, and chemicals into electrical signals that are transmitted to the brain via nerves. The brain then interprets these signals, allowing us to experience sensations like sight, hearing, touch, taste, and smell.

There are two main types of sensations: exteroceptive and interoceptive. Exteroceptive sensations involve stimuli from outside the body, such as light, sound, and touch. Interoceptive sensations, on the other hand, refer to the perception of internal bodily sensations, such as hunger, thirst, heartbeat, or emotions.

Disorders in sensation can result from damage to the nervous system, including peripheral nerves, spinal cord, or brain. Examples include numbness, tingling, pain, or loss of sensation in specific body parts, which can significantly impact a person's quality of life and ability to perform daily activities.

Quality of Life (QOL) is a broad, multidimensional concept that usually includes an individual's physical health, psychological state, level of independence, social relationships, personal beliefs, and their relationship to salient features of their environment. It reflects the impact of disease and treatment on a patient's overall well-being and ability to function in daily life.

The World Health Organization (WHO) defines QOL as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns." It is a subjective concept, meaning it can vary greatly from person to person.

In healthcare, QOL is often used as an outcome measure in clinical trials and other research studies to assess the impact of interventions or treatments on overall patient well-being.

The descending colon is a part of the large intestine in the human digestive system. It is called "descending" because it is located inferiorly and posteriorly to the transverse colon, and its direction goes downward as it continues toward the rectum. The descending colon receives digested food material from the transverse colon via the splenic flexure, also known as the left colic flexure.

The primary function of the descending colon is to absorb water, electrolytes, and any remaining nutrients from the undigested food materials that have passed through the small intestine. The descending colon also stores this waste material temporarily before it moves into the rectum for eventual elimination from the body.

The descending colon's wall contains a layer of smooth muscle, which helps propel the waste material along the gastrointestinal tract via peristalsis. Additionally, the inner mucosal lining of the descending colon contains numerous goblet cells that produce and secrete mucus to lubricate the passage of stool and protect the intestinal wall from irritation or damage caused by waste materials.

In summary, the medical definition of 'Colon, Descending' refers to a section of the large intestine responsible for absorbing water and electrolytes while storing and eliminating waste materials through peristaltic movements and mucus secretion.

Lactulose is a synthetic disaccharide, specifically a non-absorbable sugar, used in the treatment of chronic constipation and hepatic encephalopathy. It works as an osmotic laxative by drawing water into the large intestine, promoting bowel movements and softening stool. In the case of hepatic encephalopathy, lactulose is metabolized by colonic bacteria to produce acidic byproducts that lower the pH in the gut, which helps prevent the absorption of harmful substances like ammonia into the bloodstream.

Diagnostic techniques for the digestive system are medical tests and procedures used to diagnose and evaluate various conditions and diseases related to the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, large intestine, liver, gallbladder, pancreas, and associated organs. These techniques can be categorized into invasive and non-invasive methods.

Non-invasive diagnostic techniques:

1. Imaging tests: These include X-rays, computed tomography (CT) scans, magnetic resonance imaging (MRI), positron emission tomography (PET) scans, and ultrasounds. They help visualize the structure and function of the digestive organs without requiring any invasive procedures.
2. Laboratory tests: Blood, stool, and urine samples can be analyzed to detect signs of infection, inflammation, or other abnormalities related to digestive system disorders. Examples include complete blood count (CBC), liver function tests (LFTs), coagulation studies, and fecal occult blood test (FOBT).
3. Breath tests: These are used to diagnose conditions like lactose intolerance, small intestinal bacterial overgrowth (SIBO), or helicobacter pylori infection by analyzing the patient's exhaled air after consuming a specific substance.

Invasive diagnostic techniques:

1. Endoscopy: A thin, flexible tube with a light and camera attached to its end is inserted through the mouth or rectum to directly visualize the GI tract's inner lining. There are different types of endoscopies, such as gastroscopy (esophagus, stomach, and duodenum), colonoscopy (colon and rectum), sigmoidoscopy (lower part of the colon), and enteroscopy (small intestine).
2. Endoscopic ultrasound (EUS): This combines endoscopy with ultrasound technology to provide detailed images of the digestive organs' structure and surrounding tissues, allowing for accurate diagnosis and staging of conditions like cancer.
3. Biopsy: During an endoscopy or surgery, a small tissue sample can be taken from the affected area for further examination under a microscope to confirm a diagnosis or assess the severity of a condition.
4. Capsule endoscopy: A patient swallows a tiny camera-equipped capsule that transmits images as it passes through the GI tract, allowing doctors to diagnose conditions in the small intestine that may be difficult to reach with traditional endoscopes.
5. Imaging studies: Procedures like computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) scans can provide detailed images of the digestive organs and help diagnose conditions like tumors, inflammation, or obstructions.

These diagnostic techniques help healthcare providers identify and manage various gastrointestinal conditions, ensuring appropriate treatment and improved patient outcomes.

A questionnaire in the medical context is a standardized, systematic, and structured tool used to gather information from individuals regarding their symptoms, medical history, lifestyle, or other health-related factors. It typically consists of a series of written questions that can be either self-administered or administered by an interviewer. Questionnaires are widely used in various areas of healthcare, including clinical research, epidemiological studies, patient care, and health services evaluation to collect data that can inform diagnosis, treatment planning, and population health management. They provide a consistent and organized method for obtaining information from large groups or individual patients, helping to ensure accurate and comprehensive data collection while minimizing bias and variability in the information gathered.

The double-blind method is a study design commonly used in research, including clinical trials, to minimize bias and ensure the objectivity of results. In this approach, both the participants and the researchers are unaware of which group the participants are assigned to, whether it be the experimental group or the control group. This means that neither the participants nor the researchers know who is receiving a particular treatment or placebo, thus reducing the potential for bias in the evaluation of outcomes. The assignment of participants to groups is typically done by a third party not involved in the study, and the codes are only revealed after all data have been collected and analyzed.

Malabsorption syndromes refer to a group of disorders in which the small intestine is unable to properly absorb nutrients from food, leading to various gastrointestinal and systemic symptoms. This can result from a variety of underlying conditions, including:

1. Mucosal damage: Conditions such as celiac disease, inflammatory bowel disease (IBD), or bacterial overgrowth that cause damage to the lining of the small intestine, impairing nutrient absorption.
2. Pancreatic insufficiency: A lack of digestive enzymes produced by the pancreas can lead to poor breakdown and absorption of fats, proteins, and carbohydrates. Examples include chronic pancreatitis or cystic fibrosis.
3. Bile acid deficiency: Insufficient bile acids, which are necessary for fat emulsification and absorption, can result in steatorrhea (fatty stools) and malabsorption. This may occur due to liver dysfunction, gallbladder removal, or ileal resection.
4. Motility disorders: Abnormalities in small intestine motility can affect nutrient absorption, as seen in conditions like gastroparesis, intestinal pseudo-obstruction, or scleroderma.
5. Structural abnormalities: Congenital or acquired structural defects of the small intestine, such as short bowel syndrome, may lead to malabsorption.
6. Infections: Certain bacterial, viral, or parasitic infections can cause transient malabsorption by damaging the intestinal mucosa or altering gut flora.

Symptoms of malabsorption syndromes may include diarrhea, steatorrhea, bloating, abdominal cramps, weight loss, and nutrient deficiencies. Diagnosis typically involves a combination of clinical evaluation, laboratory tests, radiologic imaging, and sometimes endoscopic procedures to identify the underlying cause. Treatment is focused on addressing the specific etiology and providing supportive care to manage symptoms and prevent complications.

Acupuncture therapy is a form of traditional Chinese medicine that involves the insertion of thin needles into specific points on the body to stimulate the flow of energy (Qi), balance the vital force (Chi), and promote healing. It is based on the concept of meridians, or pathways, through which this energy flows. Acupuncture therapy is used to treat a variety of conditions, including pain, stress, anxiety, insomnia, digestive disorders, and reproductive health issues. According to Western medicine, acupuncture may work by stimulating the nervous system, increasing blood flow, and releasing natural pain-relieving chemicals called endorphins. It is generally considered safe when performed by a qualified practitioner using sterile needles.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Anxiety: A feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome. In a medical context, anxiety refers to a mental health disorder characterized by feelings of excessive and persistent worry, fear, or panic that interfere with daily activities. It can also be a symptom of other medical conditions, such as heart disease, diabetes, or substance abuse disorders. Anxiety disorders include generalized anxiety disorder, panic disorder, social anxiety disorder, and phobias.

Manometry is a medical test that measures pressure inside various parts of the gastrointestinal tract. It is often used to help diagnose digestive disorders such as achalasia, gastroparesis, and irritable bowel syndrome. During the test, a thin, flexible tube called a manometer is inserted through the mouth or rectum and into the area being tested. The tube is connected to a machine that measures and records pressure readings. These readings can help doctors identify any abnormalities in muscle function or nerve reflexes within the digestive tract.

The gastrointestinal (GI) tract, also known as the digestive tract, is a continuous tube that starts at the mouth and ends at the anus. It is responsible for ingesting, digesting, absorbing, and excreting food and waste materials. The GI tract includes the mouth, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, colon, rectum, anus), and accessory organs such as the liver, gallbladder, and pancreas. The primary function of this system is to process and extract nutrients from food while also protecting the body from harmful substances, pathogens, and toxins.

Loperamide is an antidiarrheal medication that works by slowing down the movement of the intestines. This helps to increase the time between bowel movements and reduces the amount of liquid in stools, thereby helping to relieve diarrhea. It is available over-the-counter (OTC) and by prescription, depending on the strength and formulation.

Loperamide works by binding to opioid receptors in the gut, which helps to reduce the contractions of the intestines that can lead to diarrhea. It is important to note that loperamide should not be used for longer than 2 days without consulting a healthcare professional, as prolonged use can lead to serious side effects such as constipation, dizziness, and decreased alertness.

Loperamide is also known by its brand names, including Imodium, Pepto-Bismol Maximum Strength, and Kaopectate II. It is important to follow the instructions on the label carefully when taking loperamide, and to speak with a healthcare provider if you have any questions or concerns about using this medication.

Prevalence, in medical terms, refers to the total number of people in a given population who have a particular disease or condition at a specific point in time, or over a specified period. It is typically expressed as a percentage or a ratio of the number of cases to the size of the population. Prevalence differs from incidence, which measures the number of new cases that develop during a certain period.

'Receptors, Serotonin, 5-HT3' refer to a specific type of serotonin receptor called the 5-HT3 receptor, which is a ligand-gated ion channel found in the cell membrane. Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a role in various physiological functions, including mood regulation, appetite control, and nausea.

The 5-HT3 receptor is activated by serotonin and mediates fast excitatory synaptic transmission in the central and peripheral nervous systems. It is permeable to sodium (Na+), potassium (K+), and calcium (Ca2+) ions, allowing for the rapid depolarization of neurons and the initiation of action potentials.

The 5-HT3 receptor has been a target for drug development, particularly in the treatment of chemotherapy-induced nausea and vomiting, as well as irritable bowel syndrome. Antagonists of the 5-HT3 receptor, such as ondansetron and granisetron, work by blocking the receptor and preventing serotonin from activating it, thereby reducing symptoms of nausea and vomiting.

Serotonin agents are a class of drugs that work on the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) in the brain and elsewhere in the body. They include several types of medications such as:

1. Selective Serotonin Reuptake Inhibitors (SSRIs): These drugs block the reabsorption (reuptake) of serotonin into the presynaptic neuron, increasing the availability of serotonin in the synapse to interact with postsynaptic receptors. SSRIs are commonly used as antidepressants and include medications such as fluoxetine, sertraline, and citalopram.
2. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): These drugs block the reabsorption of both serotonin and norepinephrine into the presynaptic neuron, increasing the availability of these neurotransmitters in the synapse. SNRIs are also used as antidepressants and include medications such as venlafaxine and duloxetine.
3. Serotonin Receptor Agonists: These drugs bind to and activate serotonin receptors, mimicking the effects of serotonin. They are used for various indications, including migraine prevention (e.g., sumatriptan) and Parkinson's disease (e.g., pramipexole).
4. Serotonin Receptor Antagonists: These drugs block serotonin receptors, preventing the effects of serotonin. They are used for various indications, including nausea and vomiting (e.g., ondansetron) and as mood stabilizers in bipolar disorder (e.g., olanzapine).
5. Serotonin Synthesis Inhibitors: These drugs block the enzymatic synthesis of serotonin, reducing its availability in the brain. They are used as antidepressants and include medications such as monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine.

It's important to note that while these drugs all affect serotonin, they have different mechanisms of action and are used for various indications. It's essential to consult a healthcare professional before starting any new medication.

Feces are the solid or semisolid remains of food that could not be digested or absorbed in the small intestine, along with bacteria and other waste products. After being stored in the colon, feces are eliminated from the body through the rectum and anus during defecation. Feces can vary in color, consistency, and odor depending on a person's diet, health status, and other factors.

Food hypersensitivity is an umbrella term that encompasses both immunologic and non-immunologic adverse reactions to food. It is also known as "food allergy" or "food intolerance." Food hypersensitivity occurs when the body's immune system or digestive system reacts negatively to a particular food or food component.

Immunologic food hypersensitivity, commonly referred to as a food allergy, involves an immune response mediated by immunoglobulin E (IgE) antibodies. Upon ingestion of the offending food, IgE antibodies bind to the food antigens and trigger the release of histamine and other chemical mediators from mast cells and basophils, leading to symptoms such as hives, swelling, itching, difficulty breathing, or anaphylaxis.

Non-immunologic food hypersensitivity, on the other hand, does not involve the immune system. Instead, it is caused by various mechanisms, including enzyme deficiencies, pharmacological reactions, and metabolic disorders. Examples of non-immunologic food hypersensitivities include lactose intolerance, gluten sensitivity, and histamine intolerance.

It's important to note that the term "food hypersensitivity" is often used interchangeably with "food allergy," but it has a broader definition that includes both immunologic and non-immunologic reactions.

Pain measurement, in a medical context, refers to the quantification or evaluation of the intensity and/or unpleasantness of a patient's subjective pain experience. This is typically accomplished through the use of standardized self-report measures such as numerical rating scales (NRS), visual analog scales (VAS), or categorical scales (mild, moderate, severe). In some cases, physiological measures like heart rate, blood pressure, and facial expressions may also be used to supplement self-reported pain ratings. The goal of pain measurement is to help healthcare providers better understand the nature and severity of a patient's pain in order to develop an effective treatment plan.

An abdominal reflex is a withdrawal response that occurs when the skin in the lower abdomen is stimulated, leading to contraction of the muscles in the same side of the abdomen. This reflex is mediated by the T10-L1 spinal cord segments and is typically tested during a physical examination to assess the integrity of the nervous system. A decreased or absent abdominal reflex may indicate damage to the peripheral nerves, spinal cord, or brain.

A breath test is a medical or forensic procedure used to analyze a sample of exhaled breath in order to detect and measure the presence of various substances, most commonly alcohol. The test is typically conducted using a device called a breathalyzer, which measures the amount of alcohol in the breath and converts it into a reading of blood alcohol concentration (BAC).

In addition to alcohol, breath tests can also be used to detect other substances such as drugs or volatile organic compounds (VOCs) that may indicate certain medical conditions. However, these types of breath tests are less common and may not be as reliable or accurate as other diagnostic tests.

Breath testing is commonly used by law enforcement officers to determine whether a driver is impaired by alcohol and to establish probable cause for arrest. It is also used in some healthcare settings to monitor patients who are being treated for alcohol abuse or dependence.

A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.

Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.

It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.

Serotonin antagonists are a class of drugs that block the action of serotonin, a neurotransmitter, at specific receptor sites in the brain and elsewhere in the body. They work by binding to the serotonin receptors without activating them, thereby preventing the natural serotonin from binding and transmitting signals.

Serotonin antagonists are used in the treatment of various conditions such as psychiatric disorders, migraines, and nausea and vomiting associated with cancer chemotherapy. They can have varying degrees of affinity for different types of serotonin receptors (e.g., 5-HT2A, 5-HT3, etc.), which contributes to their specific therapeutic effects and side effect profiles.

Examples of serotonin antagonists include ondansetron (used to treat nausea and vomiting), risperidone and olanzapine (used to treat psychiatric disorders), and methysergide (used to prevent migraines). It's important to note that these medications should be used under the supervision of a healthcare provider, as they can have potential risks and interactions with other drugs.

The intestinal mucosa is the innermost layer of the intestines, which comes into direct contact with digested food and microbes. It is a specialized epithelial tissue that plays crucial roles in nutrient absorption, barrier function, and immune defense. The intestinal mucosa is composed of several cell types, including absorptive enterocytes, mucus-secreting goblet cells, hormone-producing enteroendocrine cells, and immune cells such as lymphocytes and macrophages.

The surface of the intestinal mucosa is covered by a single layer of epithelial cells, which are joined together by tight junctions to form a protective barrier against harmful substances and microorganisms. This barrier also allows for the selective absorption of nutrients into the bloodstream. The intestinal mucosa also contains numerous lymphoid follicles, known as Peyer's patches, which are involved in immune surveillance and defense against pathogens.

In addition to its role in absorption and immunity, the intestinal mucosa is also capable of producing hormones that regulate digestion and metabolism. Dysfunction of the intestinal mucosa can lead to various gastrointestinal disorders, such as inflammatory bowel disease, celiac disease, and food allergies.

Serotonin receptor agonists are a class of medications that bind to and activate serotonin receptors in the body, mimicking the effects of the neurotransmitter serotonin. These drugs can have various effects depending on which specific serotonin receptors they act upon. Some serotonin receptor agonists are used to treat conditions such as migraines, cluster headaches, and Parkinson's disease, while others may be used to stimulate appetite or reduce anxiety. It is important to note that some serotonin receptor agonists can have serious side effects, particularly when taken in combination with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs). This can lead to a condition called serotonin syndrome, which is characterized by symptoms such as agitation, confusion, rapid heart rate, high blood pressure, and muscle stiffness.

Intestinal diseases refer to a wide range of conditions that affect the function or structure of the small intestine, large intestine (colon), or both. These diseases can cause various symptoms such as abdominal pain, diarrhea, constipation, bloating, nausea, vomiting, and weight loss. They can be caused by infections, inflammation, genetic disorders, or other factors. Some examples of intestinal diseases include inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, Crohn's disease, ulcerative colitis, and intestinal infections. The specific medical definition may vary depending on the context and the specific condition being referred to.

"Mental healing" is not a term that is widely used in modern medicine or psychiatry. However, it generally refers to the process of addressing and resolving psychological issues or emotional distress through non-pharmacological means, such as talk therapy, psychotherapy, or mindfulness practices.

In a broader sense, mental healing can also refer to the improvement of one's mental and emotional well-being through various holistic approaches, including self-care, stress management techniques, social support, and spiritual practices. These methods aim to help individuals develop coping skills, build resilience, and improve their overall quality of life.

It is important to note that while these approaches can be helpful in managing mental health symptoms, they should not replace evidence-based treatments for mental health conditions, such as medication or therapy with a licensed mental health professional.

Serotonin 5-HT3 receptor antagonists are a class of medications that work by blocking the serotonin 5-HT3 receptors, which are found in the gastrointestinal tract and the brain. These receptors play a role in regulating nausea and vomiting, among other functions.

When serotonin binds to these receptors, it can trigger a series of events that lead to nausea and vomiting, particularly in response to chemotherapy or surgery. By blocking the 5-HT3 receptors, serotonin cannot bind to them and therefore cannot trigger these events, which helps to reduce nausea and vomiting.

Examples of 5-HT3 receptor antagonists include ondansetron (Zofran), granisetron (Kytril), palonosetron (Aloxi), and dolasetron (Anzemet). These medications are commonly used to prevent and treat nausea and vomiting associated with chemotherapy, radiation therapy, and surgery.

The intestines, also known as the bowel, are a part of the digestive system that extends from the stomach to the anus. They are responsible for the further breakdown and absorption of nutrients from food, as well as the elimination of waste products. The intestines can be divided into two main sections: the small intestine and the large intestine.

The small intestine is a long, coiled tube that measures about 20 feet in length and is lined with tiny finger-like projections called villi, which increase its surface area and enhance nutrient absorption. The small intestine is where most of the digestion and absorption of nutrients takes place.

The large intestine, also known as the colon, is a wider tube that measures about 5 feet in length and is responsible for absorbing water and electrolytes from digested food, forming stool, and eliminating waste products from the body. The large intestine includes several regions, including the cecum, colon, rectum, and anus.

Together, the intestines play a critical role in maintaining overall health and well-being by ensuring that the body receives the nutrients it needs to function properly.

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It is a complex phenomenon that can result from various stimuli, such as thermal, mechanical, or chemical irritation, and it can be acute or chronic. The perception of pain involves the activation of specialized nerve cells called nociceptors, which transmit signals to the brain via the spinal cord. These signals are then processed in different regions of the brain, leading to the conscious experience of pain. It's important to note that pain is a highly individual and subjective experience, and its perception can vary widely among individuals.

Psychophysiologic Disorders, also known as psychosomatic disorders, refer to a category of mental health conditions where psychological stress and emotional factors play a significant role in causing physical symptoms. These disorders are characterized by the presence of bodily complaints for which no physiological explanation can be found, or where the severity of the symptoms is far greater than what would be expected from any underlying medical condition.

Examples of psychophysiologic disorders include:

* Conversion disorder: where physical symptoms such as blindness, paralysis, or difficulty swallowing occur in the absence of a clear medical explanation.
* Irritable bowel syndrome (IBS): where abdominal pain, bloating, and changes in bowel habits are thought to be caused or worsened by stress and emotional factors.
* Psychogenic nonepileptic seizures (PNES): where episodes that resemble epileptic seizures occur without any electrical activity in the brain.
* Chronic pain syndromes: where pain persists for months or years beyond the expected healing time, often accompanied by depression and anxiety.

The diagnosis of psychophysiologic disorders typically involves a thorough medical evaluation to rule out other potential causes of the symptoms. Treatment usually includes a combination of psychotherapy, such as cognitive-behavioral therapy (CBT), relaxation techniques, stress management, and sometimes medication for co-occurring mental health conditions.

Microscopic colitis is a type of inflammatory bowel disease that is characterized by chronic inflammation of the colon (large intestine) that can only be seen under a microscope. It is called "microscopic" because the inflammation is not visible to the naked eye during endoscopic examination of the colon.

There are two main types of microscopic colitis: collagenous colitis and lymphocytic colitis. Both types are more common in older adults, particularly women, and can cause chronic watery diarrhea that may be accompanied by abdominal cramps, bloating, and nausea.

In collagenous colitis, there is thickening of the collagen band (a layer of tissue) beneath the lining of the colon. In lymphocytic colitis, there is an increase in the number of lymphocytes (a type of white blood cell) in the lining of the colon.

The exact cause of microscopic colitis is not known, but it is thought to be related to a combination of genetic, environmental, and immune factors. Treatment typically involves medications to reduce inflammation and manage symptoms, such as anti-diarrheal agents, corticosteroids, and immunosuppressive drugs. In some cases, dietary modifications or elimination of certain foods may also help alleviate symptoms.

'Receptors, Serotonin, 5-HT4' refer to a specific type of serotonin receptor found in various parts of the body, including the central and peripheral nervous systems. These receptors are activated by the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and play an essential role in regulating several physiological functions, such as gastrointestinal motility, cognition, mood, and memory.

The 5-HT4 receptor is a G protein-coupled receptor (GPCR), which means it consists of seven transmembrane domains that span the cell membrane. When serotonin binds to the 5-HT4 receptor, it activates a signaling cascade within the cell, leading to various downstream effects.

The 5-HT4 receptor has been a target for drug development, particularly in treating gastrointestinal disorders such as constipation and irritable bowel syndrome (IBS). Additionally, some evidence suggests that 5-HT4 receptors may play a role in the treatment of depression, anxiety, and cognitive impairment. However, further research is needed to fully understand the therapeutic potential of targeting this receptor.

Neurasthenia is an outdated medical term that was once used to describe a condition characterized by physical and mental exhaustion, fatigue, anxiety, depression, and irritability. The diagnosis was commonly made during the late 19th and early 20th centuries. It was believed to be caused by exhaustion of the nervous system due to modern life's stresses and demands.

However, neurasthenia is not recognized as a distinct medical condition in modern psychiatry or neurology. The symptoms that were once attributed to neurasthenia are now more likely to be diagnosed as depression, anxiety disorders, chronic fatigue syndrome, or other conditions.

Pelvic pain is defined as discomfort or unpleasant sensation in the lower abdominal region, below the belly button, and between the hips. It can be acute (sudden and lasting for a short time) or chronic (persisting for months or even years), and it may be steady or intermittent, mild or severe. The pain can have various causes, including musculoskeletal issues, nerve irritation, infection, inflammation, or organic diseases in the reproductive, urinary, or gastrointestinal systems. Accurate diagnosis often requires a thorough medical evaluation to determine the underlying cause and develop an appropriate treatment plan.

The small intestine is the portion of the gastrointestinal tract that extends from the pylorus of the stomach to the beginning of the large intestine (cecum). It plays a crucial role in the digestion and absorption of nutrients from food. The small intestine is divided into three parts: the duodenum, jejunum, and ileum.

1. Duodenum: This is the shortest and widest part of the small intestine, approximately 10 inches long. It receives chyme (partially digested food) from the stomach and begins the process of further digestion with the help of various enzymes and bile from the liver and pancreas.
2. Jejunum: The jejunum is the middle section, which measures about 8 feet in length. It has a large surface area due to the presence of circular folds (plicae circulares), finger-like projections called villi, and microvilli on the surface of the absorptive cells (enterocytes). These structures increase the intestinal surface area for efficient absorption of nutrients, electrolytes, and water.
3. Ileum: The ileum is the longest and final section of the small intestine, spanning about 12 feet. It continues the absorption process, mainly of vitamin B12, bile salts, and any remaining nutrients. At the end of the ileum, there is a valve called the ileocecal valve that prevents backflow of contents from the large intestine into the small intestine.

The primary function of the small intestine is to absorb the majority of nutrients, electrolytes, and water from ingested food. The mucosal lining of the small intestine contains numerous goblet cells that secrete mucus, which protects the epithelial surface and facilitates the movement of chyme through peristalsis. Additionally, the small intestine hosts a diverse community of microbiota, which contributes to various physiological functions, including digestion, immunity, and protection against pathogens.

Psychological stress is the response of an individual's mind and body to challenging or demanding situations. It can be defined as a state of emotional and physical tension resulting from adversity, demand, or change. This response can involve a variety of symptoms, including emotional, cognitive, behavioral, and physiological components.

Emotional responses may include feelings of anxiety, fear, anger, sadness, or frustration. Cognitive responses might involve difficulty concentrating, racing thoughts, or negative thinking patterns. Behaviorally, psychological stress can lead to changes in appetite, sleep patterns, social interactions, and substance use. Physiologically, the body's "fight-or-flight" response is activated, leading to increased heart rate, blood pressure, muscle tension, and other symptoms.

Psychological stress can be caused by a wide range of factors, including work or school demands, financial problems, relationship issues, traumatic events, chronic illness, and major life changes. It's important to note that what causes stress in one person may not cause stress in another, as individual perceptions and coping mechanisms play a significant role.

Chronic psychological stress can have negative effects on both mental and physical health, increasing the risk of conditions such as anxiety disorders, depression, heart disease, diabetes, and autoimmune diseases. Therefore, it's essential to identify sources of stress and develop effective coping strategies to manage and reduce its impact.

Crohn's disease is a type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, from the mouth to the anus. It is characterized by chronic inflammation of the digestive tract, which can lead to symptoms such as abdominal pain, diarrhea, fatigue, weight loss, and malnutrition.

The specific causes of Crohn's disease are not fully understood, but it is believed to be related to a combination of genetic, environmental, and immune system factors. The disease can affect people of any age, but it is most commonly diagnosed in young adults between the ages of 15 and 35.

There is no cure for Crohn's disease, but treatments such as medications, lifestyle changes, and surgery can help manage symptoms and prevent complications. Treatment options depend on the severity and location of the disease, as well as the individual patient's needs and preferences.

The enteric nervous system (ENS) is a part of the autonomic nervous system that directly controls the gastrointestinal tract, including the stomach, small intestine, colon, and rectum. It is sometimes referred to as the "second brain" because it can operate independently of the central nervous system (CNS).

The ENS contains around 500 million neurons that are organized into two main plexuses: the myenteric plexus, which lies between the longitudinal and circular muscle layers of the gut, and the submucosal plexus, which is located in the submucosa. These plexuses contain various types of neurons that are responsible for regulating gastrointestinal motility, secretion, and blood flow.

The ENS can communicate with the CNS through afferent nerve fibers that transmit information about the state of the gut to the brain, and efferent nerve fibers that carry signals from the brain back to the ENS. However, the ENS is also capable of functioning independently of the CNS, allowing it to regulate gastrointestinal functions in response to local stimuli such as food intake, inflammation, or infection.

The ascending colon is the first part of the large intestine, which is the portion of the digestive system that follows the small intestine. It is called "ascending" because it travels upward from the right side of the abdomen toward the underside of the liver. The primary function of the ascending colon is to absorb water and electrolytes from digested food and prepare waste for elimination.

Gastroenteritis is not a medical condition itself, but rather a symptom-based description of inflammation in the gastrointestinal tract, primarily involving the stomach and intestines. It's often referred to as "stomach flu," although it's not caused by influenza virus.

Medically, gastroenteritis is defined as an inflammation of the mucous membrane of the stomach and intestines, usually resulting in symptoms such as diarrhea, abdominal cramps, nausea, vomiting, fever, and dehydration. This condition can be caused by various factors, including viral (like rotavirus or norovirus), bacterial (such as Salmonella, Shigella, or Escherichia coli), or parasitic infections, food poisoning, allergies, or the use of certain medications.

Gastroenteritis is generally self-limiting and resolves within a few days with proper hydration and rest. However, severe cases may require medical attention to prevent complications like dehydration, which can be particularly dangerous for young children, older adults, and individuals with weakened immune systems.

A placebo is a substance or treatment that has no inherent therapeutic effect. It is often used in clinical trials as a control against which the effects of a new drug or therapy can be compared. Placebos are typically made to resemble the active treatment, such as a sugar pill for a medication trial, so that participants cannot tell the difference between what they are receiving and the actual treatment.

The placebo effect refers to the phenomenon where patients experience real improvements in their symptoms or conditions even when given a placebo. This may be due to psychological factors such as belief in the effectiveness of the treatment, suggestion, or conditioning. The placebo effect is often used as a comparison group in clinical trials to help determine if the active treatment has a greater effect than no treatment at all.

Lactose intolerance is a digestive condition in which the body has difficulty digesting lactose, a sugar found in milk and dairy products. This occurs due to a deficiency or insufficiency of lactase, an enzyme produced by the small intestine that breaks down lactose into simpler sugars (glucose and galactose) for absorption. When there is not enough lactase to digest the consumed lactose, it passes undigested into the large intestine, where it is fermented by bacteria, leading to various gastrointestinal symptoms.

The symptoms of lactose intolerance may include bloating, cramps, diarrhea, nausea, and gas, usually occurring within 30 minutes to two hours after consuming dairy products. The severity of these symptoms can vary depending on the amount of lactose consumed and an individual's level of lactase deficiency or insufficiency.

Lactose intolerance is not life-threatening but can cause discomfort and may affect a person's quality of life. It is essential to manage the condition through dietary modifications, such as consuming smaller amounts of dairy products, choosing lactose-free or reduced-lactose options, or using lactase enzyme supplements before eating dairy products. In some cases, a healthcare professional may recommend additional management strategies based on an individual's specific needs and medical history.

Ischemic colitis is a condition characterized by inflammation of the large intestine (colon) due to reduced blood flow to the area. This reduction in blood flow, also known as ischemia, can be caused by various factors such as narrowing or blockage of the blood vessels that supply the colon, low blood pressure, or certain medications.

Symptoms of ischemic colitis may include sudden abdominal pain, bloody diarrhea, nausea, vomiting, and fever. In severe cases, it can lead to tissue death, perforation of the colon, and sepsis. Treatment typically involves supportive care such as fluid replacement, bowel rest, and antibiotics. In some cases, surgery may be necessary to remove damaged tissue or restore blood flow to the area.

Cathartics are a type of medication that stimulates bowel movements and evacuates the intestinal tract. They are often used to treat constipation or to prepare the bowel for certain medical procedures, such as colonoscopies. Common cathartic medications include laxatives, enemas, and suppositories.

Cathartics work by increasing the muscle contractions of the intestines, which helps to move stool through the digestive tract more quickly. They may also increase the amount of water in the stool, making it softer and easier to pass. Some cathartics, such as bulk-forming laxatives, work by absorbing water and swelling in the intestines, which helps to bulk up the stool and stimulate a bowel movement.

While cathartics can be effective at relieving constipation, they should be used with caution. Overuse of cathartics can lead to dependence on them for bowel movements, as well as electrolyte imbalances and other complications. It is important to follow the instructions carefully when using cathartic medications and to speak with a healthcare provider if constipation persists or worsens.

A case-control study is an observational research design used to identify risk factors or causes of a disease or health outcome. In this type of study, individuals with the disease or condition (cases) are compared with similar individuals who do not have the disease or condition (controls). The exposure history or other characteristics of interest are then compared between the two groups to determine if there is an association between the exposure and the disease.

Case-control studies are often used when it is not feasible or ethical to conduct a randomized controlled trial, as they can provide valuable insights into potential causes of diseases or health outcomes in a relatively short period of time and at a lower cost than other study designs. However, because case-control studies rely on retrospective data collection, they are subject to biases such as recall bias and selection bias, which can affect the validity of the results. Therefore, it is important to carefully design and conduct case-control studies to minimize these potential sources of bias.

Ulcerative colitis is a type of inflammatory bowel disease (IBD) that affects the lining of the large intestine (colon) and rectum. In ulcerative colitis, the lining of the colon becomes inflamed and develops ulcers or open sores that produce pus and mucous. The symptoms of ulcerative colitis include diarrhea, abdominal pain, and rectal bleeding.

The exact cause of ulcerative colitis is not known, but it is thought to be related to an abnormal immune response in which the body's immune system attacks the cells in the digestive tract. The inflammation can be triggered by environmental factors such as diet, stress, and infections.

Ulcerative colitis is a chronic condition that can cause symptoms ranging from mild to severe. It can also lead to complications such as anemia, malnutrition, and colon cancer. There is no cure for ulcerative colitis, but treatment options such as medications, lifestyle changes, and surgery can help manage the symptoms and prevent complications.

In medical terms, pressure is defined as the force applied per unit area on an object or body surface. It is often measured in millimeters of mercury (mmHg) in clinical settings. For example, blood pressure is the force exerted by circulating blood on the walls of the arteries and is recorded as two numbers: systolic pressure (when the heart beats and pushes blood out) and diastolic pressure (when the heart rests between beats).

Pressure can also refer to the pressure exerted on a wound or incision to help control bleeding, or the pressure inside the skull or spinal canal. High or low pressure in different body systems can indicate various medical conditions and require appropriate treatment.

Rifamycins are a class of antibiotics derived from the bacterium Amycolatopsis rifamycinica. They have a unique chemical structure and mechanism of action, which involves inhibiting bacterial DNA-dependent RNA polymerase. This leads to the prevention of bacterial transcription and ultimately results in bacteriostatic or bactericidal activity, depending on the drug concentration and the susceptibility of the bacteria.

Rifamycins are primarily used in the treatment of various types of infections caused by gram-positive and gram-negative bacteria, as well as mycobacteria. Some examples of rifamycin antibiotics include rifampin (also known as rifampicin), rifabutin, and rifapentine. These drugs are often used to treat tuberculosis, meningitis, and other serious infections. It is important to note that resistance to rifamycins can develop rapidly if the drugs are not used appropriately or if they are used to treat infections caused by bacteria that are already resistant to these antibiotics.

A Blastocystis infection is a condition caused by the presence and reproduction of the single-celled microscopic parasite, Blastocystis spp., in the human gastrointestinal tract. This organism is commonly found in the stool of both healthy individuals and those with gastrointestinal symptoms. The exact role of Blastocystis in human health and disease is not well understood, but its presence has been associated with a range of intestinal symptoms such as diarrhea, abdominal discomfort, bloating, and nausea.

Infection occurs through the ingestion of Blastocystis cysts, usually via contaminated food or water, or directly from contact with infected individuals or animals. Once inside the human body, the parasite transforms into its active form, multiplies, and sheds cysts in the stool, continuing the transmission cycle.

Diagnosis of Blastocystis infection is typically made through microscopic examination of stool samples, where the presence of the parasite can be detected. In some cases, more advanced diagnostic techniques like PCR or DNA sequencing may be used to identify the specific Blastocystis subtype involved.

Treatment for Blastocystis infections is often not necessary for asymptomatic individuals, as the organism can sometimes coexist harmoniously within the gastrointestinal tract without causing any issues. However, for those experiencing persistent or severe symptoms, antiparasitic medications like metronidazole or tinidazole may be prescribed to help eliminate the infection. Maintaining good hygiene practices and avoiding potential sources of contamination can also help prevent Blastocystis infections.

Hyperalgesia is a medical term that describes an increased sensitivity to pain. It occurs when the nervous system, specifically the nociceptors (pain receptors), become excessively sensitive to stimuli. This means that a person experiences pain from a stimulus that normally wouldn't cause pain or experiences pain that is more intense than usual. Hyperalgesia can be a result of various conditions such as nerve damage, inflammation, or certain medications. It's an important symptom to monitor in patients with chronic pain conditions, as it may indicate the development of tolerance or addiction to pain medication.

Thioxanthenes are a group of heterocyclic organic compounds that contain a thioxanthene nucleus, which is a six-membered ring containing five carbon atoms and one sulfur atom. Thioxanthenes are structurally related to phenothiazines and have been used in the synthesis of various pharmaceutical drugs, particularly antipsychotic medications.

In medical terms, thioxanthenes refer to a class of antipsychotic drugs that are used to treat various psychiatric disorders such as schizophrenia and related conditions. These drugs work by blocking dopamine receptors in the brain, which helps to reduce the symptoms of psychosis such as hallucinations, delusions, and disordered thinking.

Some examples of thioxanthene antipsychotics include chlorprothixene, thiothixene, and flupenthixol. Like other antipsychotic medications, thioxanthenes can have side effects such as extrapyramidal symptoms (EPS), which are movement disorders that can cause stiffness, tremors, or spasms. Other potential side effects of thioxanthenes may include sedation, orthostatic hypotension, and weight gain.

Bifidobacterium is a genus of Gram-positive, non-motile, often branching anaerobic bacteria that are commonly found in the gastrointestinal tracts of humans and other animals, as well as in fermented foods. These bacteria play an important role in maintaining the health and balance of the gut microbiota by aiding in digestion, producing vitamins, and preventing the growth of harmful bacteria.

Bifidobacteria are also known for their probiotic properties and are often used as dietary supplements to improve digestive health, boost the immune system, and alleviate symptoms of various gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease.

There are over 50 species of Bifidobacterium, with some of the most common ones found in the human gut being B. bifidum, B. longum, B. breve, and B. adolescentis. These bacteria are characterized by their ability to ferment a variety of carbohydrates, including dietary fibers, oligosaccharides, and sugars, producing short-chain fatty acids (SCFAs) such as acetate, lactate, and formate as end products.

Bifidobacteria have a complex cell wall structure that contains unique polysaccharides called exopolysaccharides (EPS), which have been shown to have prebiotic properties and can stimulate the growth of other beneficial bacteria in the gut. Additionally, some strains of Bifidobacterium produce antimicrobial compounds that inhibit the growth of pathogenic bacteria, further contributing to their probiotic effects.

Overall, Bifidobacterium is an important genus of beneficial bacteria that play a crucial role in maintaining gut health and promoting overall well-being.

Patient acceptance of health care refers to the willingness and ability of a patient to follow and engage in a recommended treatment plan or healthcare regimen. This involves understanding the proposed medical interventions, considering their potential benefits and risks, and making an informed decision to proceed with the recommended course of action.

The factors that influence patient acceptance can include:

1. Patient's understanding of their condition and treatment options
2. Trust in their healthcare provider
3. Personal beliefs and values related to health and illness
4. Cultural, linguistic, or socioeconomic barriers
5. Emotional responses to the diagnosis or proposed treatment
6. Practical considerations, such as cost, time commitment, or potential side effects

Healthcare providers play a crucial role in facilitating patient acceptance by clearly communicating information, addressing concerns and questions, and providing support throughout the decision-making process. Encouraging shared decision-making and tailoring care plans to individual patient needs and preferences can also enhance patient acceptance of health care.

Phenethylamines are a class of organic compounds that share a common structural feature, which is a phenethyl group (a phenyl ring bonded to an ethylamine chain). In the context of pharmacology and neuroscience, "phenethylamines" often refers to a specific group of psychoactive drugs, including stimulants like amphetamine and mescaline, a classic psychedelic. These compounds exert their effects by modulating the activity of neurotransmitters in the brain, such as dopamine, norepinephrine, and serotonin. It is important to note that many phenethylamines have potential for abuse and are controlled substances.

A diverticulum is a small sac or pouch that forms as a result of a weakness in the wall of a hollow organ, such as the intestine. These sacs can become inflamed or infected, leading to conditions like diverticulitis. Diverticula are common in the large intestine, particularly in the colon, and are more likely to develop with age. They are usually asymptomatic but can cause symptoms such as abdominal pain, bloating, constipation, or diarrhea if they become inflamed or infected.

Somatoform disorders are a group of psychological disorders characterized by the presence of physical symptoms that cannot be fully explained by a medical condition or substance abuse. These symptoms cause significant distress and impairment in social, occupational, or other important areas of functioning. The individual's belief about the symptoms is not consistent with the medical evaluation and often leads to excessive or repeated medical evaluations.

Examples of somatoform disorders include:

1. Somatization disorder: characterized by multiple physical symptoms that cannot be explained medically, affecting several parts of the body.
2. Conversion disorder: characterized by the presence of one or more neurological symptoms (such as blindness, paralysis, or difficulty swallowing) that cannot be explained medically and appear to have a psychological origin.
3. Pain disorder: characterized by chronic pain that is not fully explained by a medical condition.
4. Hypochondriasis: characterized by an excessive preoccupation with having a serious illness, despite reassurance from medical professionals.
5. Body dysmorphic disorder: characterized by the obsessive idea that some aspect of one's own body part or appearance is severely flawed and warrants exceptional measures to hide or fix it.

It's important to note that these disorders are not caused by intentional deceit or malingering, but rather reflect a genuine belief in the presence of physical symptoms and distress related to them.

Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is characterized by intellectual and developmental disabilities, distinctive facial features, and sometimes physical growth delays and health problems. The condition affects approximately one in every 700 babies born in the United States.

Individuals with Down syndrome have varying degrees of cognitive impairment, ranging from mild to moderate or severe. They may also have delayed development, including late walking and talking, and may require additional support and education services throughout their lives.

People with Down syndrome are at increased risk for certain health conditions, such as congenital heart defects, respiratory infections, hearing loss, vision problems, gastrointestinal issues, and thyroid disorders. However, many individuals with Down syndrome live healthy and fulfilling lives with appropriate medical care and support.

The condition is named after John Langdon Down, an English physician who first described the syndrome in 1866.

I'm happy to help, but I must clarify that as a assistant, I don't provide medical definitions directly. However, I can search for a reliable source that provides the information you seek. According to the National Center for Complementary and Integrative Health (NCCIH), a part of the U.S. Department of Health and Human Services:

"Yoga is a mind and body practice with historical origins in ancient Indian philosophy. Various styles of yoga combine physical postures, breathing techniques, and meditation or relaxation. Yoga is a form of exercise that can be both gentle and challenging, depending on the style and the practitioner's level of experience."

Please note that while yoga has many well-documented health benefits, it should not be used as a substitute for conventional medical care. Always consult with a healthcare professional before starting any new exercise regimen, including yoga.

Butylscopolammonium Bromide is an anticholinergic drug, which is used as a smooth muscle relaxant and an anti-spasmodic agent. It works by blocking the action of acetylcholine, a neurotransmitter in the body, on certain types of receptors, leading to relaxation of smooth muscles and reduction of spasms.

This medication is commonly used to treat gastrointestinal disorders such as irritable bowel syndrome, intestinal cramps, and spastic constipation. It may also be used in the management of bladder disorders, including neurogenic bladder and urinary incontinence.

The drug is available in various forms, including tablets, suppositories, and solutions for injection. The dosage and route of administration depend on the specific condition being treated and the patient's overall health status. As with any medication, Butylscopolammonium Bromide can cause side effects, such as dry mouth, blurred vision, dizziness, and constipation. It should be used under the guidance of a healthcare professional to ensure safe and effective treatment.

According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), neurotic disorders are not a recognized category. However, the term "neurosis" has been used historically in psychiatry and psychology to refer to a group of mental disorders characterized by anxiety, obsessions, depressive moods, phobias, or hypochondriacal fears. These symptoms are often considered to be the result of internal conflicts, typically related to stress, frustration, or interpersonal difficulties.

The DSM-5 has replaced the category of neurotic disorders with several specific mental disorders that were previously classified under this heading. These include:

1. Anxiety Disorders (e.g., panic disorder, social anxiety disorder, generalized anxiety disorder)
2. Obsessive-Compulsive and Related Disorders (e.g., obsessive-compulsive disorder, body dysmorphic disorder, hoarding disorder)
3. Trauma- and Stressor-Related Disorders (e.g., post-traumatic stress disorder, acute stress disorder, adjustment disorders)
4. Mood Disorders (e.g., major depressive disorder, persistent depressive disorder)
5. Somatic Symptom and Related Disorders (e.g., illness anxiety disorder, conversion disorder)

These specific disorders are defined by their own unique diagnostic criteria and should be evaluated based on those guidelines.

A Blastocystis is a single-celled microscopic organism (protozoan) that can inhabit the human gastrointestinal tract. It is found in the stool of infected individuals and is classified as a stramenopile, which is a group of organisms that also includes algae and water molds.

Blastocystis is often considered a commensal organism, meaning that it can live in the human gut without causing any harm. However, some studies have suggested that Blastocystis may be associated with gastrointestinal symptoms such as diarrhea, abdominal pain, and bloating, particularly in people with compromised immune systems or other underlying health conditions.

There is ongoing debate among researchers about the role of Blastocystis in human health, and more research is needed to fully understand its impact on the gut microbiome and overall health. Currently, there is no consensus on whether or not to treat Blastocystis in asymptomatic individuals.

Metabolic syndrome, also known as Syndrome X, is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. It is not a single disease but a group of risk factors that often co-occur. According to the American Heart Association and the National Heart, Lung, and Blood Institute, a person has metabolic syndrome if they have any three of the following five conditions:

1. Abdominal obesity (waist circumference of 40 inches or more in men, and 35 inches or more in women)
2. Triglyceride level of 150 milligrams per deciliter of blood (mg/dL) or greater
3. HDL cholesterol level of less than 40 mg/dL in men or less than 50 mg/dL in women
4. Systolic blood pressure of 130 millimeters of mercury (mmHg) or greater, or diastolic blood pressure of 85 mmHg or greater
5. Fasting glucose level of 100 mg/dL or greater

Metabolic syndrome is thought to be caused by a combination of genetic and lifestyle factors, such as physical inactivity and a diet high in refined carbohydrates and unhealthy fats. Treatment typically involves making lifestyle changes, such as eating a healthy diet, getting regular exercise, and losing weight if necessary. In some cases, medication may also be needed to manage individual components of the syndrome, such as high blood pressure or high cholesterol.

Dietary fiber, also known as roughage, is the indigestible portion of plant foods that makes up the structural framework of the plants we eat. It is composed of cellulose, hemicellulose, pectin, gums, lignins, and waxes. Dietary fiber can be classified into two categories: soluble and insoluble.

Soluble fiber dissolves in water to form a gel-like material in the gut, which can help slow down digestion, increase feelings of fullness, and lower cholesterol levels. Soluble fiber is found in foods such as oats, barley, fruits, vegetables, legumes, and nuts.

Insoluble fiber does not dissolve in water and passes through the gut intact, helping to add bulk to stools and promote regular bowel movements. Insoluble fiber is found in foods such as whole grains, bran, seeds, and the skins of fruits and vegetables.

Dietary fiber has numerous health benefits, including promoting healthy digestion, preventing constipation, reducing the risk of heart disease, controlling blood sugar levels, and aiding in weight management. The recommended daily intake of dietary fiber is 25-38 grams per day for adults, depending on age and gender.

Mind-body therapies refer to a group of interventions that aim to facilitate the connection between the mind and body, with the goal of enhancing mental, emotional, and physical well-being. These therapies are based on the understanding that our thoughts, emotions, and beliefs can significantly impact our physical health.

Examples of mind-body therapies include:

1. Meditation: Focused concentration to achieve a mentally clear and emotionally calm state.
2. Yoga: A practice that combines physical postures, breathing exercises, meditation, and a distinct philosophy.
3. Guided imagery: Deliberate mental visualization of a peaceful setting or situation to promote relaxation and stress reduction.
4. Progressive muscle relaxation: Systematically tensing and then releasing various muscle groups to promote relaxation and stress reduction.
5. Biofeedback: A technique that uses electronic devices to help individuals learn to control physiological responses, such as heart rate or blood pressure.
6. Hypnotherapy: The use of hypnosis to facilitate therapeutic change by accessing the subconscious mind.
7. Tai Chi and Qigong: Ancient Chinese practices that involve slow, gentle movements, deep breathing, and meditation.
8. Mindfulness-based stress reduction (MBSR): A structured program that combines mindfulness meditation, yoga, and cognitive therapy to help manage stress and improve overall well-being.
9. Acupuncture and acupressure: Traditional Chinese medicine practices that involve the stimulation of specific points on the body using needles or pressure, respectively, to promote healing and balance.
10. Prayer and spiritual practices: Engaging in religious or spiritual activities to foster a sense of connection, meaning, and purpose.

These therapies can be used as complementary approaches alongside conventional medical treatments or as standalone interventions for various health conditions, such as stress management, pain relief, anxiety reduction, and overall wellness promotion.

Gastric emptying is the process by which the stomach empties its contents into the small intestine. In medical terms, it refers to the rate and amount of food that leaves the stomach and enters the duodenum, which is the first part of the small intestine. This process is regulated by several factors, including the volume and composition of the meal, hormonal signals, and neural mechanisms. Abnormalities in gastric emptying can lead to various gastrointestinal symptoms and disorders, such as gastroparesis, where the stomach's ability to empty food is delayed.

Direct service costs are expenses that can be directly attributed to the delivery of a specific service or program. These costs are typically related to items such as personnel, supplies, and equipment that are used exclusively for the provision of that service. Direct service costs can be contrasted with indirect costs, which are expenses that are not easily linked to a particular service or program and may include things like administrative overhead, rent, and utilities.

Examples of direct service costs in a healthcare setting might include:

* Salaries and benefits for medical staff who provide patient care, such as doctors, nurses, and therapists
* Costs of medications and supplies used to treat patients
* Equipment and supplies needed to perform diagnostic tests or procedures, such as X-ray machines or surgical instruments
* Rent or lease payments for space that is dedicated to providing patient care services.

It's important to accurately track direct service costs in order to understand the true cost of delivering a particular service or program, and to make informed decisions about resource allocation and pricing.

Phytotherapy is the use of extracts of natural origin, especially plants or plant parts, for therapeutic purposes. It is also known as herbal medicine and is a traditional practice in many cultures. The active compounds in these plant extracts are believed to have various medicinal properties, such as anti-inflammatory, analgesic, or sedative effects. Practitioners of phytotherapy may use the whole plant, dried parts, or concentrated extracts to prepare teas, capsules, tinctures, or ointments for therapeutic use. It is important to note that the effectiveness and safety of phytotherapy are not always supported by scientific evidence, and it should be used with caution and preferably under the guidance of a healthcare professional.

Medical Definition:

"Risk factors" are any attribute, characteristic or exposure of an individual that increases the likelihood of developing a disease or injury. They can be divided into modifiable and non-modifiable risk factors. Modifiable risk factors are those that can be changed through lifestyle choices or medical treatment, while non-modifiable risk factors are inherent traits such as age, gender, or genetic predisposition. Examples of modifiable risk factors include smoking, alcohol consumption, physical inactivity, and unhealthy diet, while non-modifiable risk factors include age, sex, and family history. It is important to note that having a risk factor does not guarantee that a person will develop the disease, but rather indicates an increased susceptibility.

A colonoscopy is a medical procedure used to examine the large intestine, also known as the colon and rectum. It is performed using a flexible tube with a tiny camera on the end, called a colonoscope, which is inserted into the rectum and gently guided through the entire length of the colon.

The procedure allows doctors to visually inspect the lining of the colon for any abnormalities such as polyps, ulcers, inflammation, or cancer. If any polyps are found during the procedure, they can be removed immediately using special tools passed through the colonoscope. Colonoscopy is an important tool in the prevention and early detection of colorectal cancer, which is one of the leading causes of cancer-related deaths worldwide.

Patients are usually given a sedative to help them relax during the procedure, which is typically performed on an outpatient basis in a hospital or clinic setting. The entire procedure usually takes about 30-60 minutes to complete, although patients should plan to spend several hours at the medical facility for preparation and recovery.

In medical terms, compliance refers to the degree to which a patient follows the recommendations or instructions of their healthcare provider. This may include taking prescribed medications as directed, following a treatment plan, making lifestyle changes, or attending follow-up appointments. Good compliance is essential for achieving the best possible health outcomes and can help prevent complications or worsening of medical conditions. Factors that can affect patient compliance include forgetfulness, lack of understanding of the instructions, cost of medications or treatments, and side effects of medications. Healthcare providers can take steps to improve patient compliance by providing clear and concise instructions, discussing potential barriers to compliance, and involving patients in their care plan.

Gastroesophageal reflux (GER) is the retrograde movement of stomach contents into the esophagus, which can cause discomfort and symptoms. It occurs when the lower esophageal sphincter (a ring of muscle between the esophagus and stomach) relaxes inappropriately, allowing the acidic or non-acidic gastric contents to flow back into the esophagus.

Gastroesophageal reflux becomes gastroesophageal reflux disease (GERD) when it is more severe, persistent, and/or results in complications such as esophagitis, strictures, or Barrett's esophagus. Common symptoms of GERD include heartburn, regurgitation, chest pain, difficulty swallowing, and chronic cough or hoarseness.

Serotonin plasma membrane transport proteins, also known as serotonin transporters (SERTs), are membrane-spanning proteins that play a crucial role in the regulation of serotonergic neurotransmission. They are responsible for the reuptake of serotonin (5-hydroxytryptamine or 5-HT) from the synaptic cleft back into the presynaptic neuron, thereby terminating the signal transmission and allowing for its recycling or degradation.

Structurally, SERTs belong to the family of sodium- and chloride-dependent neurotransmitter transporters and contain 12 transmembrane domains with intracellular N- and C-termini. The binding site for serotonin is located within the transmembrane domain, while the substrate-binding site is formed by residues from both the transmembrane and extracellular loops.

Serotonin transporters are important targets for various psychotropic medications, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). These drugs act by blocking the SERT, increasing synaptic concentrations of serotonin, and enhancing serotonergic neurotransmission. Dysregulation of serotonin transporters has been implicated in several neurological and psychiatric disorders, such as major depressive disorder, anxiety disorders, obsessive-compulsive disorder, and substance abuse.

Homeopathy is a complementary and alternative medicine (CAM) system, developed in the late 18th century by Samuel Hahnemann, based on the principle of "like cures like." This concept suggests that a substance that causes symptoms in a healthy person can be used in very dilute quantities to treat similar symptoms in illness. The dilutions are so extreme that no molecules of the original substance remain, leading to significant controversy and skepticism over any potential therapeutic effect. Homeopathic remedies are typically made from plants, minerals, or animals, and are often highly individualized for each patient based on their specific symptoms, mental and emotional state, and overall constitution. Despite its widespread use, homeopathy lacks robust scientific evidence supporting its efficacy beyond placebo effects, and it is not considered a mainstream medical practice in most countries.

Prospective studies, also known as longitudinal studies, are a type of cohort study in which data is collected forward in time, following a group of individuals who share a common characteristic or exposure over a period of time. The researchers clearly define the study population and exposure of interest at the beginning of the study and follow up with the participants to determine the outcomes that develop over time. This type of study design allows for the investigation of causal relationships between exposures and outcomes, as well as the identification of risk factors and the estimation of disease incidence rates. Prospective studies are particularly useful in epidemiology and medical research when studying diseases with long latency periods or rare outcomes.

Complementary therapies refer to a group of diverse medical and health care systems, practices, and products that are not presently considered an integral part of conventional allopathic medicine. They are often used in conjunction with conventional treatments and are intended to facilitate the physical and emotional well-being of the patient. Complementary therapies can include a wide range of interventions such as acupuncture, chiropractic care, massage therapy, herbal medicine, yoga, meditation, guided imagery, hypnotherapy, and homeopathy, among others. It is important to note that while some complementary therapies have been shown to be effective for certain conditions, others lack scientific evidence of their safety and efficacy. Therefore, it is always recommended to consult with a healthcare provider before starting any new complementary therapy.

The abdomen refers to the portion of the body that lies between the thorax (chest) and the pelvis. It is a musculo-fascial cavity containing the digestive, urinary, and reproductive organs. The abdominal cavity is divided into several regions and quadrants for medical description and examination purposes. These include the upper and lower abdomen, as well as nine quadrants formed by the intersection of the midline and a horizontal line drawn at the level of the umbilicus (navel).

The major organs located within the abdominal cavity include:

1. Stomach - muscular organ responsible for initial digestion of food
2. Small intestine - long, coiled tube where most nutrient absorption occurs
3. Large intestine - consists of the colon and rectum; absorbs water and stores waste products
4. Liver - largest internal organ, involved in protein synthesis, detoxification, and metabolism
5. Pancreas - secretes digestive enzymes and hormones such as insulin
6. Spleen - filters blood and removes old red blood cells
7. Kidneys - pair of organs responsible for filtering waste products from the blood and producing urine
8. Adrenal glands - sit atop each kidney, produce hormones that regulate metabolism, immune response, and stress response

The abdomen is an essential part of the human body, playing a crucial role in digestion, absorption, and elimination of food and waste materials, as well as various metabolic processes.

Colonic diseases refer to a group of medical conditions that affect the colon, also known as the large intestine or large bowel. The colon is the final segment of the digestive system, responsible for absorbing water and electrolytes, and storing and eliminating waste products.

Some common colonic diseases include:

1. Inflammatory bowel disease (IBD): This includes conditions such as Crohn's disease and ulcerative colitis, which cause inflammation and irritation in the lining of the digestive tract.
2. Diverticular disease: This occurs when small pouches called diverticula form in the walls of the colon, leading to symptoms such as abdominal pain, bloating, and changes in bowel movements.
3. Colorectal cancer: This is a type of cancer that develops in the colon or rectum, often starting as benign polyps that grow and become malignant over time.
4. Irritable bowel syndrome (IBS): This is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel movements, but without any underlying structural or inflammatory causes.
5. Constipation: This is a common condition characterized by infrequent bowel movements, difficulty passing stools, or both.
6. Infectious colitis: This occurs when the colon becomes infected with bacteria, viruses, or parasites, leading to symptoms such as diarrhea, abdominal cramps, and fever.

Treatment for colonic diseases varies depending on the specific condition and its severity. Treatment options may include medications, lifestyle changes, surgery, or a combination of these approaches.

Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter that is found primarily in the gastrointestinal (GI) tract, blood platelets, and the central nervous system (CNS) of humans and other animals. It is produced by the conversion of the amino acid tryptophan to 5-hydroxytryptophan (5-HTP), and then to serotonin.

In the CNS, serotonin plays a role in regulating mood, appetite, sleep, memory, learning, and behavior, among other functions. It also acts as a vasoconstrictor, helping to regulate blood flow and blood pressure. In the GI tract, it is involved in peristalsis, the contraction and relaxation of muscles that moves food through the digestive system.

Serotonin is synthesized and stored in serotonergic neurons, which are nerve cells that use serotonin as their primary neurotransmitter. These neurons are found throughout the brain and spinal cord, and they communicate with other neurons by releasing serotonin into the synapse, the small gap between two neurons.

Abnormal levels of serotonin have been linked to a variety of disorders, including depression, anxiety, schizophrenia, and migraines. Medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), are commonly used to treat these conditions.

Chinese herbal drugs, also known as traditional Chinese medicine (TCM), refer to a system of medicine that has been practiced in China for thousands of years. It is based on the belief that the body's vital energy, called Qi, must be balanced and flowing freely for good health. TCM uses various techniques such as herbal therapy, acupuncture, dietary therapy, and exercise to restore balance and promote healing.

Chinese herbal drugs are usually prescribed in the form of teas, powders, pills, or tinctures and may contain one or a combination of herbs. The herbs used in Chinese medicine are typically derived from plants, minerals, or animal products. Some commonly used Chinese herbs include ginseng, astragalus, licorice root, and cinnamon bark.

It is important to note that the use of Chinese herbal drugs should be under the guidance of a qualified practitioner, as some herbs can interact with prescription medications or have side effects. Additionally, the quality and safety of Chinese herbal products can vary widely depending on the source and manufacturing process.

Heartburn is not a cardiac condition, but rather a digestive disorder. The medical term for heartburn is "pyrosis." It is characterized by a burning sensation in the chest or throat, caused by the reflux of stomach acid into the esophagus. This backflow of acid can irritate the lining of the esophagus, leading to discomfort and pain. Heartburn often occurs after eating, when lying down, or during bending over, and it can be worsened by certain foods, drinks, or medications. Chronic or severe heartburn may indicate a more serious condition, such as gastroesophageal reflux disease (GERD).

Pain perception refers to the neural and psychological processes involved in receiving, interpreting, and responding to painful stimuli. It is the subjective experience of pain, which can vary greatly among individuals due to factors such as genetics, mood, expectations, and past experiences. The perception of pain involves complex interactions between the peripheral nervous system (which detects and transmits information about tissue damage or potential harm), the spinal cord (where this information is processed and integrated with other sensory inputs), and the brain (where the final interpretation and emotional response to pain occurs).

Quigley EM (2005). "Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?". Chinese Journal of ... Bercik P, Verdu EF, Collins SM (June 2005). "Is irritable bowel syndrome a low-grade inflammatory bowel disease?". ... such as irritable bowel syndrome and fibromyalgia. The connection between these syndromes is unknown. A number of treatments ... and celiac disease is recommended before a diagnosis of irritable bowel syndrome is made. An upper endoscopy with small bowel ...
"Overview , Irritable bowel syndrome in adults: diagnosis and management , Guidance , NICE". www.nice.org.uk. 2008-02-23. ... The study that supported the findings was a $8.5 million NIH grant called the Irritable Bowel Syndrome Outcome Study (IBSOS), ... Linedale, Ecushla C; Andrews, Jane M (2017). "Diagnosis and management of irritable bowel syndrome: a guide for the generalist ... Mayer, Emeran A. (2008-04-17). "Irritable Bowel Syndrome". New England Journal of Medicine. 358 (16): 1692-1699. doi:10.1056/ ...
Irritable bowel syndrome. Interstitial cystitis. Regular scuba diving. The temporomandibular joints are the dual articulation ... irritable bowel syndrome, interstitial cystitis, headache, chronic lower back pain and chronic neck pain. These disorders have ... temporomandibular pain dysfunction syndrome, temporomandibular joint syndrome, temporomandibular dysfunction syndrome, ... Costen's syndrome at Who Named It? Costen JB (October 1997). "A syndrome of ear and sinus symptoms dependent upon disturbed ...
Irritable bowel syndrome Celiac disease Non-celiac gluten sensitivity Partial bowel obstruction Gastric dumping syndrome or ... ISBN 1-56924-600-9. Excerpted with author's permission at Help for Irritable Bowel Syndrome (see IBS Diet Section) (2021, ... There are many causes of bloating, including: diet, irritable bowel syndrome, lactose intolerance, reflux, and constipation. ... Retrieved on 2010-01-26 Talley NJ (November 2006). "Irritable bowel syndrome". Internal Medicine Journal. 36 (11): 724-8. doi: ...
Irritable Bowel Syndrome, Cyclic vomiting syndrome, Some persistent fatigue and Chronic Pain syndromes, such as Fibromyalgia ( ... or Irritable Bowel Syndrome with Inflammatory Bowel Disease. This is important to recognise as additional treatment approaches ... "Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic ... For example, irritable bowel syndrome is thought to affect 4.1%, and fibromyalgia 0.2-11.4% of the global population. A recent ...
Clinical Perspectives: Irritable bowel syndrome. NEJM 358:1692-9, 2008 Rhee SH, Pothoulakis C, Mayer EA. Principles and ... In addition to his longstanding research into the pathophysiology of irritable bowel syndrome, his funded research efforts have ... Functional Chronic Pain Syndromes: Similarities And Differences In Clinical Presentation And Pathophysiology Seattle, IASP ... inflammatory bowel disorders such as ulcerative colitis and Crohn's disease. His research efforts into these brain gut diseases ...
2005). "Colonic transit, bowel movements, stool form, and abdominal pain in irritable bowel syndrome by treatments with calcium ... A study looked at the effects of calcium polycarbophil on general irritable bowel syndrome (IBS) symptoms. Fourteen patients ... Torii A, Toda G (May 2004). "Management of irritable bowel syndrome". Internal Medicine. 43 (5): 353-9. doi:10.2169/ ... July 1999). "Recommendations for the management of irritable bowel syndrome in family practice. IBS Consensus Conference ...
Pittler, M.H.; Ernst, E. (1998). "Peppermint oil for irritable bowel syndrome: A critical review and metaanalysis". The ... Hadley, S. K.; Gaarder, S. M. (2005). "Treatment of irritable bowel syndrome". American Family Physician. 72 (12): 2501-6. PMID ...
... is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) who have: chronic IBS ... Lièvre M (September 2002). "Alosetron for irritable bowel syndrome". BMJ. 325 (7364): 555-6. doi:10.1136/bmj.325.7364.555. PMC ... Barbehenn E, Lurie P, Wolfe SM (December 2000). "Alosetron for irritable bowel syndrome". Lancet. 356 (9246): 2009-10. doi: ... is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only. It ...
Kumar, A.; Rinwa P.; Sharma N. (2012). "Irritable Bowel Syndrome: A Review". J Phys Pharm Adv. 2 (2): 97-108. DeVault KR, ... focuses mainly on the study of common functional gastrointestinal disorders such as irritable bowel syndrome, the most common ...
Dai C, Zheng CQ, Jiang M, Ma XY, Jiang LJ (2013). "Probiotics and irritable bowel syndrome". World Journal of Gastroenterology ... reduce bowel movements in diarrhea-predominant IBS patients, and reduce the incidence of antibiotic-, traveler's-, and HIV/AIDS ...
Gibson, Peter R.; Varney, Jane; Malakar, Sreepurna; Muir, Jane G. (1 May 2015). "Food components and irritable bowel syndrome ... April 2015). "Behçet's syndrome patients exhibit specific microbiome signature". Autoimmunity Reviews. 14 (4): 269-276. doi: ...
Camilleri M (October 2012). "Peripheral mechanisms in irritable bowel syndrome". N Engl J Med. 367 (17): 1626-35. doi:10.1056/ ...
... is effective for the treatment of irritable bowel syndrome; however, because of its side effects, it should be ... Trinkley KE, Nahata MC (2014). "Medication management of irritable bowel syndrome". Digestion. 89 (4): 253-67. doi:10.1159/ ... Stuttering and restless legs syndrome are some of the less common associations. A less common side effect of amitriptyline is ... Amitriptyline may improve pain and urgency intensity associated with bladder pain syndrome and can be used in the management of ...
Assessment of pain thresholds in the ampulla recti has been proposed as diagnostic measure in irritable bowel syndrome. A ... Irritable Bowel Syndrome: Diagnosis and Clinical Management. Wiley. pp. 237-. ISBN 978-1-118-44474-0. The barostat is as ... Irritable Bowel Syndrome: Diagnosis and Treatment. W.B. Saunders. pp. 72-. ISBN 978-0-7020-2655-3. Evidence of ... increasing ... most notably irritable bowel syndrome, functional dyspep- sia, and NCCP. More than 40 years ago, intraesophageal balloon ...
MacDermott RP (January 2007). "Treatment of irritable bowel syndrome in outpatients with inflammatory bowel disease using a ... Fiber supplements may be effective in an overall dietary plan for managing irritable bowel syndrome by modification of food ... In preliminary clinical trials, they have proven effective for the treatment of irritable bowel syndrome. Examples of vegetable ... Soluble fiber supplements may be beneficial for alleviating symptoms of irritable bowel syndrome, such as diarrhea or ...
... postural orthostatic tachycardia syndrome (POTS), fibromyalgia, irritable bowel syndrome (IBS) and idiopathic hypersomnia, ... 645, 663-6. ISBN 978-0-89042-555-8. "Definition & Facts for Irritable Bowel Syndrome , NIDDK". National Institute of Diabetes ... "Sex-Gender Differences in the Effectiveness of Treatment of Irritable Bowel Syndrome: A Systematic Review". International ... Turner Syndrome] is one of the most common genetic syndromes that occurs only in females... "Prostate vs. testicular cancer: ...
Several studies have found a low-FODMAP diet to improve digestive symptoms in adults with irritable bowel syndrome, but its ... A low-FODMAP diet is recommended for managing patients with irritable bowel syndrome (IBS) and can reduce digestive symptoms of ... van der Waaij LA, Stevens J (2014). "The low FODMAP diet as a therapy for irritable bowel syndrome". Nederlands Tijdschrift ... FODMAPs are not the cause of irritable bowel syndrome or other functional gastrointestinal disorders, but rather a person ...
... and with newly diagnosed chronic fatigue syndrome and irritable bowel syndrome. Dermatitis herpetiformis is included in other ... Clinical guideline 61: Irritable bowel syndrome. London, 2008. Fasano Alessio, Caio Giacomo; Catassi Carlo, Volta Umberto (July ... Frequently, the symptoms are ascribed to irritable bowel syndrome (IBS), only later to be recognised as coeliac disease. In ... Irvine, AJ; Chey, WD; Ford, AC (January 2017). "Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic ...
In irritable bowel syndrome, the normal activity of the gut muscle is lost. The muscle spasms result in symptoms such as ... "Detailed Info About Irritable bowel syndrome". Retrieved 2017-07-26. "Alverine Citrate 60 mg Hard Capsules". Drugs.com. ... This prevents the muscle spasms which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease ... A combination of alverine citrate and simeticone (ACS) for irritable bowel syndrome therapy were compared with placebo in a ...
Hunter, JO (2009). "DO HORSES GET IRRITABLE BOWEL SYNDROME?". Equine Veterinary Journal. 41: 836-40. Proudman, C. J.; Hunter, J ... Can an enzyme-rich malt extract improve the symptoms of irritable bowel syndrome? (Report). ISRCTN. doi:10.1186/isrctn14173715 ... King, TS; Elia, M; Hunter, JO (1998) [October 10, 1998]. "Abnormal colonic fermentation in irritable bowel syndrome". The ... "Does Enzyme Rich Malt Extract improve symptoms and quality of life for those with Irritable Bowel Syndrome?". ECU. Retrieved 3 ...
"Irritable bowel syndrome - Symptoms and causes". Mayo Clinic. Retrieved 5 September 2022. "Opioid-Induced Hyperalgesia: How ... and morphine are used to stop diarrhoea and combat irritable bowel syndrome (IBS) in its diarrhoeal and cyclical forms as well ... Opium/opioid preparations are used often as a last resort where pain is severe and the bowels are organically loose. It is ... better to treat IBS with a non psycho-tropic opioid such as loperamide hydrochloride which stays contained in the bowel, ...
Cannabinoid hyperemesis syndrome (CHS) B4. Rumination syndrome C. Bowel disorders C1. Irritable bowel syndrome (IBS) IBS with ... Postprandial distress syndrome H2a2. Epigastric pain syndrome H2b. Irritable bowel syndrome (IBS) H2c. Abdominal migraine H2d. ... Genetics of irritable bowel syndrome. Am J Gastroenterol 2008;103:2100-2104. Tran L, Chaloner A, Sawalha AH, et al. Importance ... Globally, irritable bowel syndrome and functional dyspepsia alone may affect 16-26% of the population. There is considerable ...
"Research programme: irritable bowel syndrome therapeutics - RaQualia". AdisInsight. Springer Nature Switzerland AG. 23 February ... and was developed for the treatment of irritable bowel syndrome, but was ultimately discontinued from development following ... for the treatment of irritable bowel syndrome". Bioorganic & Medicinal Chemistry Letters. 25 (2): 236-40. doi:10.1016/j.bmcl. ...
... and irritable bowel syndrome. Other reviews covered osteoarthritis, migraines, postoperative ecchymosis and edema, delayed- ... "Homeopathy for treatment of irritable bowel syndrome". The Cochrane Database of Systematic Reviews. 9 (9): CD009710. doi: ... "bowel nosodes") faeces. While Hahnemann was opposed to such preparations, modern homeopaths often use them although there is no ...
... functional bowel disorders such as irritable bowel syndrome that produced symptoms of bloating were attributed to increased ... When excessive or malodorous, flatus can be a sign of a health disorder, such as irritable bowel syndrome, celiac disease or ... When excessive or malodorous, flatus can be a sign of a health disorder, such as irritable bowel syndrome, celiac disease, non- ... The proportion of hydrogen produced may be increased in some patients with irritable bowel syndrome, but this does not affect ...
The differential diagnoses include colon cancer, inflammatory bowel disease, ischemic colitis, and irritable bowel syndrome, as ... The differential diagnoses include irritable bowel syndrome. Preventive measures include altering risk factors such as obesity ... After resection of the affected bowel segment, an anvil and spike are used to anastomose the remaining segments of the bowel. ... When excessive inflammation of the colon renders primary bowel resection too risky, bowel resection with colostomy remains an ...
... bowel obstruction, or diarrhea-predominant irritable bowel syndrome.[medical citation needed] Lubiprostone is a bicyclic fatty ... Lubiprostone is also used to treat irritable bowel syndrome with constipation... in women who are at least 18 years of age. " ... "In the news: FDA approves one drug for irritable bowel syndrome but suspends another". Harvard Health. 2008-08-01. "Competitive ... Lubiprostone is a safe and efficacious drug for the treatment of chronic idiopathic constipation and irritable bowel syndrome ...
Linaclotide (Linzess in the US and Mexico, and as Constella elsewhere), a drug used to treat irritable bowel syndrome with ... Hornby, PJ (2015). "Drug discovery approaches to irritable bowel syndrome". Expert Opinion on Drug Discovery. 10 (8): 809-24. ...
Yu SW, Rao SS (September 2014). "Advances in the management of constipation-predominant irritable bowel syndrome: the role of ... Love BL, Johnson A, Smith LS (July 2014). "Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome". ... Yu SW, Rao SS (September 2014). "Advances in the management of constipation-predominant irritable bowel syndrome: the role of ... Linaclotide is indicated to treat irritable bowel syndrome with constipation and chronic constipation with no known cause. In ...
Bixquert Jiménez M (August 2009). "Treatment of irritable bowel syndrome with probiotics. An etiopathogenic approach at last ... randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome". European Journal ... and synbiotics in inflammatory bowel disease". Clinical and Experimental Gastroenterology. 7: 473-487. doi:10.2147/CEG.S27530. ...
Quigley EM (2005). "Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?". Chinese Journal of ... Bercik P, Verdu EF, Collins SM (June 2005). "Is irritable bowel syndrome a low-grade inflammatory bowel disease?". ... such as irritable bowel syndrome and fibromyalgia. The connection between these syndromes is unknown. A number of treatments ... and celiac disease is recommended before a diagnosis of irritable bowel syndrome is made. An upper endoscopy with small bowel ...
... N Engl J Med. 2017; 376(26):2566-2578 (ISSN: 1533-4406). Ford AC; Lacy BE; Talley NJ. ...
Irritable bowel syndrome (IBS) can cause a great deal of discomfort. Learn about the symptoms, causes, and treatments of IBS. ... Irritable Bowel Syndrome (Nemours Foundation) * Irritable Bowel Syndrome in Children (National Institute of Diabetes and ... Faecal microbiota transplantation for patients with irritable bowel syndrome: abridged secondary... * Irritable Bowel Syndrome ... Irritable Bowel Syndrome (Mayo Foundation for Medical Education and Research) * What Is IBS? (International Foundation for ...
The placebo response rate in irritable bowel syndrome and inflammatory bowel disease. Dig Dis. 2009;27 Suppl 1:68-75. ↵ ... Review article: gut-directed hypnotherapy in the management of irritable bowel syndrome and inflammatory bowel disease. Aliment ... Hypnosis for irritable bowel syndrome: the empirical evidence of therapeutic effects. Int J Clin Exp Hypn. 2006;54(1):7-20. ↵ ... Treatment of irritable bowel syndrome using complementary and alternative medicine. J Chin Med Assoc. 2009;72(6):294-300. ↵ ...
Read about irritable bowel syndrome (IBS), a common intestinal disorder that affects the colon. ... Síndrome del intestino irritable. What Is Irritable Bowel Syndrome?. Irritable bowel syndrome (IBS) is a common intestinal ... How Is Irritable Bowel Syndrome Diagnosed?. There is no specific test for IBS. To diagnose it, doctors ask about symptoms and ... How Is Irritable Bowel Syndrome Treated?. Theres no cure for IBS. But there are ways to take control of IBS symptoms. ...
People with irritable bowel syndrome, or IBS, have a gut that wont behave, even when it seems like theres nothing wrong.. ... "articlePagePath" :"/content/aarpe/en/home/health/conditions-treatments/info-2022/irritable-bowel-syndrome", "aarpId" : " ... Bottom line: If youve got abdominal pain, bloating and a change in bowel habits, go see a doctor, said Eric Shah, M.D., a ... Abdominal pain, bloating and a change in bowel habits warrant a call to your doctor ...
Irritable bowel syndrome happens when the muscles in the large intestine have trouble doing their job. ... Irritable bowel syndrome (IBS) can cause cramps, gas, and bloating in the belly. It also can make kids have to poop a lot ( ... Irritable Bowel Syndrome. Say: EAR-it-uh-bul BOW-ul SIN-drohm ... When you dont get enough sleep, you might feel irritable. But ... did you know that some kids have intestines that get irritable? This can happen when the muscles in the large intestine have ...
What is Irritable Bowel Syndrome?. Healthy Moments Episode:. April 3, 2023. Many people suffer from IBS but dont know that ... Irritable bowel syndrome, known as IBS, is estimated to affect up to 10 to 15 percent of the population. Many people suffer ... Do you have frequent abdominal pain along with diarrhea or constipation, or both? If so, you may have irritable bowl syndrome ... Symptoms include pain or discomfort in the abdomen and changes in bowel habits. These symptoms may come and go repeatedly. ...
Find out where to get help and support for irritable bowel syndrome (IBS). ... Seeing a dietitian for irritable bowel syndrome (IBS). A GP may refer you to an NHS dietitian if general diet tips for IBS, ... Further help and support - Irritable bowel syndrome (IBS) Contents. * What is IBS? ...
Consumers with Irritable Bowel Syndrome are the target market for UK start-up Fodilicious, which has developed a line of low- ... Energy beverage developed for consumers with Irritable Bowel Syndrome 03-Oct-2022. By Flora Southey ...
New research discussed the hypothesis that irritable bowel syndrome (IBS) may result from gravity. ... Study: Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome. Image Credit: Emily frost/Shutterstock. Background. IBS ... Spiegel B. (2022). Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome. Am J Gastroenterol. 2022.doi: 10.14309/ajg. ... Can herbal remedies, spices, and dietary fibers offer effective treatment options for children with irritable bowel syndrome ( ...
There is a direct association of symptoms of Irritable Bowel Syndrome (IBS) and stress. ... Irritable Bowel Syndrome (IBS) and Stress Response. News-Medical. https://www.news-medical.net/health/Irritable-Bowel-Syndrome ... 2023, January 24). Irritable Bowel Syndrome (IBS) and Stress Response. News-Medical. Retrieved on September 30, 2023 from https ... There is a direct association of symptoms of Irritable Bowel Syndrome (IBS) and stress. ...
... is a functional GI disorder characterized by abdominal pain and altered bowel habits in the absence of a specific and unique ... encoded search term (Irritable Bowel Syndrome (IBS)) and Irritable Bowel Syndrome (IBS) What to Read Next on Medscape ... Advances in Treatment of Irritable Bowel Syndrome With Constipation * Irritable Bowel Syndrome Diagnostic Criteria (Manning ... postinfectious irritable bowel syndrome). Risk factors for developing postinfectious irritable bowel syndrome include longer ...
Digestive disorders like irritable bowel syndrome (IBS) are common - IBS affects up to 20% of the worlds population and can ... Digestive disorders like irritable bowel syndrome (IBS) are common - IBS affects up to 20% of the worlds population and can ...
The classic Irritable Bowel Syndrome or IBS. You know how some people claim to carry stress in their necks, their groin or ...
Irritable bowel syndrome (IBS) causes abdominal pain accompanied by diarrhea, constipation, or periods of both. Here are 9 ... Irritable bowel syndrome (IBS) can affect both men and women, but occurs more frequently in women. Common symptoms in both ... Irritable bowel syndrome (IBS) affects between 6%-18% of people worldwide (. 1. ). ... Accelerated bowel transit in IBS can also result in a sudden, immediate urge to have a bowel movement. Some people describe ...
Irritable Bowel Symptoms disappear after resolving an emotional issue. *Step by step through a first class Irritable Bowel ... Irritable Bowel Syndrome fades in 4 brief EFT sessions Important Note: This article was written prior to 2010 and is now ... This was for me a very exciting exploration and resolution of issues buried within a case of Irritable Bowel Syndrome, or IBS, ... If she is hungry she eats what she chooses instead of fearing the consequences of adding to the content of her bowels. My sense ...
... Neurogastroenterol Motil. 2017 Mar;29(3). doi: 10.1111/nmo. ... Background: Sleep disturbances are well-documented among persons with irritable bowel syndrome (IBS). Difficulty in falling ... Irritable Bowel Syndrome / diagnosis * Irritable Bowel Syndrome / epidemiology* * Irritable Bowel Syndrome / physiopathology* ...
... which may be the source of chronic gut pain associated with irritable bowel syndrome ... Irritable bowel syndrome may be caused by overreacting gut cells. Epithelial cells in the gut remain active in mice even after ... The chronic gut pain people with irritable bowel syndrome (IBS) experience may be due to long-lasting activation of a select ... which may be the source of chronic gut pain associated with irritable bowel syndrome ...
For twenty years I thought I was the only person in the world with Irritable Bowel Syndrome (IBS). I wasnt, and neither are ... People with Irritable Bowel Syndrome desperately want to eat without fear, but until now they have had nowhere to turn to learn ... Irritable Bowel Syndrome (also known as spastic colon or IBS) is a devastating and incurable condition that afflicts up to 20% ... YOU ARE NOT ALONE! For twenty years I thought I was the only person in the world with Irritable Bowel Syndrome (IBS). I wasnt ...
Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Symptoms can vary from person to person, ... Medications for Irritable Bowel Syndrome. Other names: IBS; Spastic colon. Irritable bowel syndrome (IBS) is a common disorder ... Irritable Bowel Syndrome with Diarrhea (8 drugs) Alternative treatments for Irritable Bowel Syndrome. The following products ... Topics under Irritable Bowel Syndrome. *Irritable Bowel Syndrome with Constipation (9 drugs) ...
What is irritable bowel syndrome (IBS)?. Irritable bowel syndrome (IBS) is a disorder of the intestines. It causes belly pain, ... Symptoms of irritable bowel syndrome (IBS) may last for a long time. But IBS doesnt cause cancer or shorten your life. ... Between 7 and 10 out of 100 people in the world have irritable bowel syndrome.footnote 1 But most people with IBS dont see a ... You have been diagnosed with irritable bowel syndrome (IBS) and your symptoms get worse, begin to disrupt your activities, or ...
An irritable bowel syndrome (IBS) is a disorder of the intestine which is much more common in women than men, and this disorder ... Although it may seem uncomfortable for a person to suffer from an irritable bowel syndrome, the bowel has no abnormality, and ... An irritable bowel syndrome (IBS) is a disorder of the intestine which is much more common in women than men, and this disorder ... Make an effort in eliminating any food or drink that seems to trigger an attack of irritable bowel syndrome. The best way to do ...
Peppermint is extremely useful for indigestion and GI cramps - It is anti-bacterial, increases gastric juices, and relieves gas, nausea, vomiting, and morning sickness.
A new form of irritable bowel syndrome (IBS) that occurs after an acute bout of diverticulitis was described by UCLA ... Irritable Bowel Syndrome. Irritable bowel syndrome (IBS) causes recurrent abdominal pain or discomfort and a fluctuating ... called Post-Diverticulitis Irritable Bowel Syndrome (PDV-IBS), validates the irritable bowel symptoms that many patients report ... Increased Risk of Irritable Bowel Syndrome for Shift Workers. A new study says, shift workers face a significantly increased ...
Irritable bowel syndrome (IBS). Got your attention? Because one out of five people reading this probably has it. But peppermint ... According to Brierley and colleagues, these hyperactive pain proteins are present in the bowel and can respond to these ... we know a little more about how peppermint may work in calming that irritable colon … and that maybe we need to put down that ... and other cooling compounds may soothe some of the bowel hypersensitivity of IBS, according to research from Australia, led by ...
... with natural cures, such as probiotics, a gluten-free diet, taking turmeric and peppermint ... This new RCT human study shows that melatonin can be very beneficial in the treatment of irritable bowel syndrome (IBS) as ... satisfaction with bowel habits, diseases impact on patients life, and stool consistency ... Irritable Bowel Syndrome Treatment #poststop:before { content: ""; display: block; height: 120px; margin: -120px 0 0; } Sort by ...
Irritable bowel syndrome is a digestive system problem. Symptoms include cramping pain, bloating, diarrhoea and constipation. ... Key points about irritable bowel syndrome. *irritable bowel syndrome (IBS) is a problem with the way the digestive system works ... What is irritable bowel syndrome?. Irritable bowel syndrome (IBS) is a problem with the way the digestive system works. ... See the KidsHealth page about inflammatory bowel disease.. What causes irritable bowel syndrome?. ​The cause is uncertain. The ...
Aims: The aims of this study were to better define the relationship between irritable bowel syndrome (IBS) and psychiatric ... The complex interplay between gastrointestinal and psychiatric symptoms in irritable bowel syndrome: A longitudinal assessment ... Irritable Bowel Syndrome / complications * Irritable Bowel Syndrome / drug therapy* * Irritable Bowel Syndrome / ...
Many of those people assume theyre experiencing the symptoms of irritable bowel syndrome (IBS). But according to the American ... It causes your gut to be more sensitive and changes how the muscles in your bowel work. As a result, IBS causes symptoms such ... Colon cancer: Changes in bowel habits can be a sign of color cancer, but other symptoms of cancer include rectal bleeding and ... If you notice changes in your bowel habits or abdominal discomfort that does not go away, its time to seek medical help. Your ...
  • Worrisome or "alarm" features include onset at greater than 50 years of age, weight loss, blood in the stool, or a family history of inflammatory bowel disease. (wikipedia.org)
  • Other conditions that may present similarly include celiac disease, microscopic colitis, inflammatory bowel disease, bile acid malabsorption, and colon cancer. (wikipedia.org)
  • Unlike other digestive conditions, such as inflammatory bowel disease , IBS doesn't carry a risk of permanent damage to the intestines. (kidshealth.org)
  • IBS doesn't cause more serious diseases, such as inflammatory bowel disease or cancer. (stlukesonline.org)
  • Are inflammatory bowel disease and irritable bowel syndrome the same? (harvard.edu)
  • Is this the same thing as inflammatory bowel disease? (harvard.edu)
  • Inflammatory bowel disease (IBD) refers to two conditions, ulcerative colitis and Crohn's disease, which are caused by a malfunctioning immune system. (harvard.edu)
  • IBS is not the same as inflammatory bowel disease (Crohn's disease and ulcerative colitis). (kidshealth.org.nz)
  • It's important to be aware that other gastrointestinal disorders, such as celiac disease, inflammatory bowel disease (IBD) , lactose intolerance and parasitic infections, can cause similar symptoms. (besthealthmag.ca)
  • Irritable bowel syndrome (IBS) is a "disorder of gut-brain interaction" characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements. (wikipedia.org)
  • The primary symptoms of IBS are abdominal pain or discomfort in association with frequent diarrhea or constipation and a change in bowel habits. (wikipedia.org)
  • Recent findings suggest that an allergy triggered peripheral immune mechanism may underlie the symptoms associated with abdominal pain in patients with irritable bowel syndrome. (wikipedia.org)
  • Bottom line: If you've got abdominal pain, bloating and a change in bowel habits, go see a doctor, said Eric Shah, M.D., a gastroenterologist and researcher at the Dartmouth Geisel School of Medicine in Hanover, New Hampshire. (aarp.org)
  • Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and altered bowel habit in the absence of a specific and unique organic pathology, although microscopic inflammation has been documented in some patients. (medscape.com)
  • This condition involves changes in frequency or form of bowel movements and lower abdominal pain ( 1 ). (healthline.com)
  • The most common symptom of IBS is lower abdominal pain that is less severe after a bowel movement. (healthline.com)
  • In contrast, constipation in IBS includes abdominal pain that eases with bowel movements. (healthline.com)
  • However, abdominal pain that improves after a bowel movement and a sensation of incomplete bowel movements after passing stool are signs of IBS. (healthline.com)
  • A new study says, shift workers face a significantly increased risk of developing Irritable Bowel Syndrome (IBS) and abdominal pain compared to those working a standard day-time schedule. (medindia.net)
  • It can cause abdominal pain and changes in bowel habits. (rxwiki.com)
  • To pinpoint a diagnosis of irritable bowel syndrome (IBS), we look for symptoms that include altered frequency or consistency in your stools and abdominal pain and discomfort that last at least three days a month for three consecutive months. (besthealthmag.ca)
  • The main symptoms of IBS are abdominal pain or discomfort, bloating and altered bowel habits such as diarrhea and/or constipation. (lesliebeck.com)
  • Irritable bowel syndrome is a functional gastrointestinal disorder characterised by abdominal pain or discomfort and accompanied by a change in bowel habit. (bmj.com)
  • Altered gastrointestinal motility may contribute to the change in bowel habit reported by some patients, 5 and a combination of smooth muscle spasm, visceral hypersensitivity, and abnormalities of central pain processing may explain the abdominal pain that is an essential part of the symptom complex. (bmj.com)
  • Irritable Bowel Syndrome (IBS) or spastic colon is a bowel disorder characterized by diarrhea, constipation, gas, bloating and chronic abdominal pain. (ibstreatmentcenter.com)
  • As many as 11 million Americans have irritable bowel syndrome with constipation, a disorder that causes abdominal pain, according to Cambridge, Massachusetts-based Ironwood. (blogspot.com)
  • Irritable Bowel Syndrome (IBS) is defined as a chronic relapsing functional bowel disorder of unknown causes which is characterised by attacks of abdominal pain and change of bowel habit resulting in diarrhoea or constipation or both. (ajol.info)
  • Consuming a prebiotic agave fructan jelly could reduce visceral hypersensitivity with short-chain fatty acids, attenuate anxiety and modulate brain activity in irritable bowel syndrome patients with constipation, according to a recent study. (nutraingredients.com)
  • Vitamin D supplements could help to ease the symptoms of Irritable Bowel Syndrome (IBS) that include bloating, stomach cramps and constipation, a UK review concludes. (nutraingredients.com)
  • Daily intake of Saccharomyces cerevisiae CNCM I-3856 may improve symptoms of Irritable Bowel Syndrome with constipation (IBS-C), says a new study from Lesaffre Human Care. (nutraingredients.com)
  • Constipation is defined as having fewer than three bowel movements per week ( 12 ). (healthline.com)
  • Constipation in IBS also often causes a sensation of an incomplete bowel movement. (healthline.com)
  • Spastic colon, also called irritable bowel syndrome or IBS, is when you have gas, bloating, diarrhea and/or constipation with a negative medical workup. (tasteforlife.com)
  • The goal of treatment for IBS with predominantly diarrhea (IBS-D) is to reduce the excessive bowel movements, while treatment for IBS with predominantly constipation (IBS-C) will aim for regular bowel movements, each requiring different nutritional approaches [ 1 ]. (springer.com)
  • bowel syndrome with constipation. (blogspot.com)
  • IBS is often classified into three subtypes based on predominant bowel habits: IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), and mixed IBS (IBS-M). (naturaltherapycenter.com)
  • Rao S, Yu S, Fedewa A. Systematic review: dietary fiber and FODMAP- restricted diet in the management of constipation and the irritable bowel syndrome. (medscape.com)
  • What Are the Signs & Symptoms of Irritable Bowel Syndrome? (kidshealth.org)
  • A new proprietary method to deliver the Indian botanical extract Boswellia, could boost bioavailability and help manage the symptoms of irritable bowel syndrome (IBS), finds a study by Italian botanical player Indena. (nutraingredients.com)
  • There is a direct association of symptoms of Irritable Bowel Syndrome (IBS) and stress. (news-medical.net)
  • Many of those people assume they're experiencing the symptoms of irritable bowel syndrome (IBS). (uclahealth.org)
  • The preparation can combat the cause of the symptoms of irritable bowel syndrome. (symbiopharm.de)
  • A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. (medscape.com)
  • Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial. (medscape.com)
  • It can cause abdominal cramping, bloating, and a change in bowel habits. (medlineplus.gov)
  • Symptoms include pain or discomfort in the abdomen and changes in bowel habits. (nih.gov)
  • But an estimated 10% to 15% of American adults experience ongoing abdominal discomfort and changes in bowel habits that last for more than three months. (uclahealth.org)
  • Changes in bowel habits can be a sign of color cancer, but other symptoms of cancer include rectal bleeding and weight loss, which do not indicate IBS. (uclahealth.org)
  • If you notice changes in your bowel habits or abdominal discomfort that does not go away, it's time to seek medical help. (uclahealth.org)
  • IBS is a disruptive gastrointestinal condition characterized by bloating, changes in bowel habits, and pain that affects up to 20 percent of the world's population, both children and adults. (integrativepractitioner.com)
  • 9 10 Current guidelines for the management of irritable bowel syndrome in the United Kingdom recommend that the diagnosis should be made on clinical grounds alone, without the need for invasive investigations, unless alarm symptoms such as rectal bleeding or weight loss are present. (bmj.com)
  • During this time he conducted a series of systematic reviews and meta-analyses to inform the American College of Gastroenterology's monograph for the management of irritable bowel syndrome. (bmj.com)
  • ACG Clinical Guideline: Management of Irritable Bowel Syndrome. (physiciansweekly.com)
  • Onset may be triggered by an intestinal infection ("post-infectious irritable bowel syndrome") or a stressful life event. (wikipedia.org)
  • Gut bacteria appears to alter intestinal as well as behavioural patterns in irritable bowel syndrome (IBS) patients in a discovery that points to the strength of microbiota-directed therapies. (nutraingredients.com)
  • The underlying cause of IBS is unknown, but symptoms may arise due to uncoordinated intestinal contractions that affect bowel movements and hypersensitive nerves in the gut. (harvard.edu)
  • It is known that the intestinal flora in patients with irritable bowel differs from that in healthy individuals. (symbiopharm.de)
  • Moreover, the intestinal flora in patients with irritable bowel syndrome appears to be generally less stable. (symbiopharm.de)
  • Buscopan 10 mg Tablets are indicated for the relief of spasm of the genito- urinary tract or gastro- intestinal tract and for the symptomatic relief of Irritable Bowel Syndrome. (janusinfo.se)
  • Disorders such as anxiety, major depression, and chronic fatigue syndrome are common among people with IBS. (wikipedia.org)
  • Classically IBS patients tend to have high levels of anxiety and in addition there is a considerable overlap of symptoms of IBS with other functional disorders including fibromyalgia and chronic fatigue syndrome. (news-medical.net)
  • The chronic gut pain people with irritable bowel syndrome (IBS) experience may be due to long-lasting activation of a select group of gut cells . (newscientist.com)
  • While medicines and diet changes can manage the symptoms associated with a bad gut and bowel, you can also try turning to alternate healing mediums to attend to chronic pain symptoms. (indiatimes.com)
  • Irritable bowel syndrome is a chronic relapsing and remitting condition, 8 9 and a significant proportion of patients will consult their general practitioner with symptoms. (bmj.com)
  • Irritable bowel syndrome (IBS) is a prolonged bowel illness that is generally stress-related and is characterized by a variety of gastrointestinal problems, the most prominent of which is chronic visceral abdominal discomfort. (bvsalud.org)
  • Irritable Bowel Syndrome (also known as spastic colon or IBS) is a devastating and incurable condition that afflicts up to 20% of the world's population, children as well as adults. (helpforibs.com)
  • More often, however, it is caused by an infection, and most patients' spastic colon resolves when the underlying bacterial, fungal, and parasitic bowel infections are treated. (tasteforlife.com)
  • These poisons and alarming chemical substances, along with the "typical" American diet lead to poor chrones assimilation, spastic bowels, burden gain, low energy, headaches, and numerous added abhorrent human maladiesand all but every other disease of mankind! (nutrihealth.org)
  • There may also be urgency for bowel movements, a feeling of incomplete evacuation (tenesmus) or bloating. (wikipedia.org)
  • In some cases, the symptoms are relieved by bowel movements. (wikipedia.org)
  • The Rome IV criteria differ from the Rome III criteria in basing bowel habit on stool forms solely during days with abnormal bowel movements rather than on the total number of bowel movements. (medscape.com)
  • IBS can cause a wide range of symptoms, including digestive issues, changes in bowel movements, fatigue, and anxiety. (healthline.com)
  • An older study in 200 adults found that those with diarrhea-predominant IBS had, on average, 12 bowel movements weekly - more than twice the amount of adults without IBS ( 8 ). (healthline.com)
  • Pain is the most important clue that changes in bowel movements are not related to diet or common, mild infections ( 15 ). (healthline.com)
  • Throughout each phase, they continue to experience pain relieved by bowel movements. (healthline.com)
  • In preparation for the appointment, keep a symptom diary that tracks how you're feeling, what you eat and your bowel movements. (uclahealth.org)
  • The most common symptoms of IBS include pain or discomfort in your abdomen and changes in how often you have bowel movements or how your stools look. (rxwiki.com)
  • This review provides an updated overview of observational and intervention studies investigating the effect of a low-FODMAP (fermentable oligo-, di- and monosaccharides, and polyols) diet (LFD) on gastrointestinal (GI) symptoms, quality of life (QoL), nutritional adequacy, and gut microbiome in irritable bowel syndrome (IBS) patients. (springer.com)
  • Now, thanks to Stuart Brierley and his Australian research team, we know a little more about how peppermint may work in calming that irritable colon … and that maybe we need to put down that mustard. (earthsky.org)
  • Because nerves in the colon (also called the large bowel or large intestine) are linked to the brain, stressful events like family problems, moving, school tests, or going on holiday can affect how the colon works. (kidshealth.org.nz)
  • Irritable bowel syndrome (IBS) is a group of symptoms that affect the large intestine (colon) and include pain or discomfort in your abdomen and changes in your bowel movement patterns. (rxwiki.com)
  • Bowel and colon disorders may be extremely crippling and even fatal. (nutrihealth.org)
  • And the truth chrones is, keeping your colon clean blameless may administer you a chance to live a long and physically strong existenceWhy A Faultless Bowel Is So Valuable! (nutrihealth.org)
  • Prebiotics are specialized plant fibers that beneficially nourish the good bacteria already in the large bowel or colon. (nih.gov)
  • In a recent study published in the American Journal of Gastroenterology , the author proposed and discussed the hypothesis that irritable bowel syndrome (IBS) may result from gravity. (news-medical.net)
  • Digestive disorders like irritable bowel syndrome (IBS) are common - IBS affects up to 20% of the world's population and can have a significant impact on quality of life and societal expenses. (ccnm.edu)
  • The exact cause of irritable bowel syndrome is not clear and not understood fully, but experts reckon there is an abnormality in the manner that muscles contract in the large intestine of the digestive system. (hubpages.com)
  • While people with irritable bowel syndrome (IBS) may experience some of the same symptoms as people with IBD, there is no obvious inflammation within the digestive tract. (harvard.edu)
  • Irritable bowel syndrome is a digestive system problem. (kidshealth.org.nz)
  • Bowel Absolve Program choice get rid of ALL the toxic development of blow constituents in chrones your ENTIRE digestive tract. (nutrihealth.org)
  • If symptoms of an irritated bowel still continue to trouble you, even after clearing up your system, probiotics can come to your rescue and soothe the digestive system. (indiatimes.com)
  • A comprehensive history, physical examination, and tailored laboratory and radiographic studies can establish a diagnosis of irritable bowel syndrome in most patients. (medscape.com)
  • Strictly speaking, irritable bowel syndrome is a diagnosis by exclusion made by a doctor. (symbiopharm.de)
  • Consumers with Irritable Bowel Syndrome are the target market for UK start-up Fodilicious, which has developed a line of low-FODMAP energy drinks. (foodnavigator.com)
  • Irritable bowel syndrome patients, who had performed hydrogen/methane breath testing for fructose and lactose malabsorption and had received dietary advice regarding the low FODMAP diet, were included. (nih.gov)
  • Gibson P. The evidence base for efficacy of the low FODMAP diet in irritable bowel syndrome: is it ready for prime time as a first-line therapy? (medscape.com)
  • Altered communication between the brain and bowel may speed up or slow down the normal transit time of stool. (healthline.com)
  • When transit time slows, the bowel absorbs more water from stool, and it becomes more difficult to pass ( 11 ). (healthline.com)
  • diarrhea predominant irritable bowel syndrome. (who.int)
  • A meta-analysis of published evidence upholds the efficacy of endogenous melatonin to improve irritable bowel syndrome (IBS) severity in diagnosed patients. (nutraingredients.com)
  • The discovery of this new condition, called Post-Diverticulitis Irritable Bowel Syndrome (PDV-IBS), validates the irritable bowel symptoms that many patients report long after suffering a bout of diverticulitis, but that many physicians wave off as being part of the original condition, said study senior author Dr. Brennan Spiegel, an associate professor of medicine at the David Geffen School of Medicine at UCLA. (medindia.net)
  • St. John's wort, also known as Tipton's weed a herbal supplement, doesn't benefit patients with irritable bowel syndrome (IBS), say Mayo Clinic researchers. (medindia.net)
  • 11 12 As a result general practitioners are increasingly responsible for the initial management of patients with irritable bowel syndrome and are expected to refer only a minority to secondary care. (bmj.com)
  • A new, improved diagnostic classification technique enables stratification of pediatric patients with irritable bowel syndrome (IBS) with greater precision so they can receive optimal treatment, according to a new study published in the Journal of Molecular Diagnostics . (integrativepractitioner.com)
  • Eswaran S, Chey WD, Jackson K, Pillai S, Chey SW, Han-Markey T. A diet low in fermentable oligo-, di-, and mono-saccharides and polyols improves quality of life and reduces activity impairment in patients with irritable bowel syndrome and diarrhea . (medscape.com)
  • Irritable bowel syndrome (IBS) is a problem that affects the large intestine. (medlineplus.gov)
  • Irritable bowel syndrome (IBS) affects between 6%-18% of people worldwide ( 1 ). (healthline.com)
  • The positive effect of movement on IBS symptoms likely stems from the stress-relieving and bowel motility benefits it confers. (va.gov)
  • Irritable bowel syndrome (IBS) is a gastrointestinal disorder that can negatively impact the motility of the bowel and even how your brain interprets sensations from the bowel. (besthealthmag.ca)
  • The purpose of this brief review is to describe the existing research on nutraceutical supplements in irritable bowel syndrome management, including probiotics , prebiotics , symbiotics, herbal products, and dietary fibers . (bvsalud.org)
  • Dietary therapy for irritable bowel syndrome . (medscape.com)
  • 2 3 4 No known structural or anatomical explanation accounts for the pathophysiology of irritable bowel syndrome, and the exact cause remains unknown, although several mechanisms have been proposed. (bmj.com)
  • Supplements containing Lesaffre Human Care's ibSium (Saccharomyces cerevisiae CNCM I-3856) may improve gastrointestinal symptoms in people with Irritable Bowel Syndrome (IBS). (nutraingredients.com)
  • According to Brierley and colleagues, these hyperactive pain proteins are present in the bowel and can respond to these chemicals, possibly explaining how peppermint helps cool the discomfort of IBS. (earthsky.org)
  • Other symptoms are bloating, mucus in the stools, and a feeling that the bowels haven't completely emptied. (stlukesonline.org)
  • Other common symptoms are bloating, mucus in the stools, and a feeling that you haven't completely emptied your bowels. (stlukesonline.org)
  • Irritable bowel syndrome (IBS) can cause cramps, gas, and bloating in the belly. (kidshealth.org)
  • It's a functional disorder, which means that the bowel doesn't work as it should. (nutrihealth.org)
  • Irritable bowel syndrome is a functional gut disorder. (symbiopharm.de)
  • Irritable bowel syndrome (IBS) is a functional bowel disorder of unknown aetiology affecting up to 15% of the population. (bmj.com)
  • But did you know that some kids have intestines that get irritable? (kidshealth.org)
  • Irritable bowel syndrome (IBS) is a disorder of the intestines. (stlukesonline.org)
  • Review methods Randomised controlled trials comparing fibre, antispasmodics, and peppermint oil with placebo or no treatment in adults with irritable bowel syndrome were eligible for inclusion. (bmj.com)
  • People with irritable bowel syndrome, or IBS, have a gut that won't behave, even when it seems like there's nothing wrong. (aarp.org)
  • The majority of people living with Irritable Bowel Syndrome (IBS) could well be deficient in vitamin D, severely affecting their quality of life, a study has found. (nutraingredients.com)
  • People with Irritable Bowel Syndrome desperately want to eat without fear, but until now they have had nowhere to turn to learn how. (helpforibs.com)
  • Four bowel patterns may be seen with irritable bowel syndrome, and these remain in the Rome IV classification. (medscape.com)
  • Four bowel patterns may be seen with irritable bowel syndrome. (medscape.com)
  • [ 1 ] Population-based studies estimate the prevalence of irritable bowel syndrome at 10-20% and the incidence of irritable bowel syndrome at 1-2% per year. (medscape.com)
  • There's is no immediate cure for irritable bowel syndrome, however, this condition can be treated very easily by altering the diet and lifestyle. (hubpages.com)
  • A first of its kind US trial demonstrated that diet changes can help those with irritable bowel syndrome (IBS) overcome uncomfortable symptoms. (lesliebeck.com)
  • Background: Irritable bowel syndrome (IBS) is a common gastrointestinal tract disorder, affecting 10-20% of adults worldwide. (mdpi.com)
  • According to current estimates, up to 11 million adults in Germany suffer from irritable bowel syndrome (IBS). (symbiopharm.de)
  • Other symptoms include an urgent need to move the bowels and feeling of incomplete evacuation. (carle.org)
  • Other treatments include bowel relaxants like peppermint oil , cognitive behavior therapy, and hypnotherapy ( 6 ). (healthline.com)
  • Overall there are very few irritable bowel syndrome treatments available. (symbiopharm.de)
  • Retrieved on September 30, 2023 from https://www.news-medical.net/health/Irritable-Bowel-Syndrome-(IBS)-and-Stress-Response.aspx. (news-medical.net)
  • Multi-strain probiotics obtained from the human gut have shown promising effects in reducing irritable bowel syndrome (IBS) disease severity, and should be further studied as a potential treatment for the condition, say Korean researchers. (nutraingredients.com)
  • What is the treatment for my child with irritable bowel syndrome? (kidshealth.org.nz)
  • Current treatment for irritable bowel syndrome (IBS) is suboptimal. (nih.gov)
  • Objective To determine the effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome. (bmj.com)
  • Conclusion Fibre, antispasmodics, and peppermint oil were all more effective than placebo in the treatment of irritable bowel syndrome. (bmj.com)
  • Symbioflor ® 2 is a probiotic drug with living Escherichia coli bacteria for the treatment of irritable bowel syndrome. (symbiopharm.de)
  • The Role of Nutraceutical Supplements in the Treatment of Irritable Bowel Syndrome: A Mini Review. (bvsalud.org)
  • The first description of the condition was in 1820, while the current term irritable bowel syndrome came into use in 1944. (wikipedia.org)
  • IBS is an alarmingly common condition in the U.S. military population, with estimates of up to one-third of military women having this syndrome. (va.gov)
  • Although it may seem uncomfortable for a person to suffer from an irritable bowel syndrome, the bowel has no abnormality, and the condition is not a serious threat for the person's health nor does it have complications to cause further agony. (hubpages.com)
  • A new form of irritable bowel syndrome (IBS) that occurs after an acute bout of diverticulitis was described by UCLA researchers. (medindia.net)