Kadsura
Lignans
The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis. (1/7)
The C(18) dibenzocyclooctadiene lignans including three novel schizanrin F (1), G (2), H (3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C(19) homolignan named schiarisanrin E (5), together with the known C(18) lignans, gomisin B (6), G (7) and (+)-gomisin K(3) (8) were obtained from Schizandra arisanensis. Gomisin B, G and (+)-gomisin K(3) showed moderate to strong activity for antihepatitis in anti-HBsAg (human type B hepatitis, surface antigen) and/or anti-HBeAg (human type B hepatitis, e antigen) tests. The structural elucidations of new compounds 1-3 and 5 were based on two-dimensional (2D) NMR techniques including COSY, HMQC, HMBC, NOESY and CD spectra. Preliminary structure-activity relationship studies for these isolated lignans are also discussed. (+info)Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease. (2/7)
Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively. (+info)New lignans from Kadsura coccinea and their nitric oxide inhibitory activities. (3/7)
In vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage like cell line RAW 264.7. Further fractionation of the chloroform extract led to the isolation of three new lignans, including two dibenzocyclooctadiene lignans and one arylnaphthalene lignan, together with other three known dibenzocyclooctadiene lignans. This is the first report of NO production inhibitory activity of Kadsura coccinea and first report about the isolation of arylnaphthalene lignan from K. coccinea. (+info)Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis. (4/7)
Four new nona-oxygenated C18 dibenzocyclooctadiene lignans, kadsuphilins C-F (1-4), were isolated from the EtOAc soluble portion of the alcoholic extract of the aerial parts of Kadsura philippinensis. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments, comparison of the spectral data with those of the related metabolites. The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1-4 also have been evaluated. (+info)Three new compounds from Kadsura longipedunculata. (5/7)
Two new tetrahydrofuran lignans, kadlongirins A and B (1, 2), a new cadinane-type sesquiterpenoid, 2,7-dihydroxy-11,12-dehydrocalamenene (3), together with seven known lignans, grandisin, fragransin B1, vladirol F, kadsuralignan C, otobaphenol, isoanwulignan, and 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-phenol, were isolated from the leaves and stems of Kadsura longipedunculata. The structures of these new compounds were elucidated by spectroscopic methods. Compound 2 exhibited weak anti-human immunodeficiency virus-1 activity with an EC50 value of 16.0 microg/ml, and therapeutic index (TI) value of 6.7. (+info)Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations. (6/7)
(+info)New Lignans from the Leaves and Stems of Kadsura philippinensis. (7/7)
(+info)"Kadsura" is a botanical term, not a medical one. It refers to a genus of plants in the family Schisandraceae. These plants are native to tropical and subtropical regions of Asia and have been used in traditional medicine in some cultures. For example, Kadsura japonica has been used in Japanese Kampo medicine for various purposes such as treating arthritis and skin diseases. However, it is important to note that the scientific evidence supporting these uses is generally limited, and more research is needed before any specific health benefits can be confirmed.
Lignans are a type of plant compound that have antioxidant and estrogen properties. They are found in various plants such as seeds, grains, fruits, and vegetables. Once consumed, some lignans can be converted by intestinal bacteria into enterolactone and enterodiol, which can have weak estrogenic or anti-estrogenic effects in the body. These compounds have been studied for their potential health benefits, including reducing the risk of cancer and heart disease. However, more research is needed to fully understand their effects and potential health benefits.
Cyclooctanes are a class of organic compounds that contain a cyclic octane structure, which is an eight-carbon ring. These molecules can exist in various conformations, including "crowded" or "eclipsed" conformations, where the carbon-hydrogen bonds are arranged in a way that leads to steric strain. This strain makes cyclooctanes less stable than other cycloalkanes, such as cyclohexane. The properties and behavior of cyclooctanes can be studied and applied in fields like chemistry, biochemistry, and materials science.