Kidney Cortex Necrosis
Kidney Cortex
Kidney
Necrosis
Cerebral Cortex
Tumor Necrosis Factor-alpha
Prefrontal Cortex
Visual Cortex
Acute Kidney Injury
Lypressin
Encyclopedias as Topic
Kidney Tubular Necrosis, Acute
Immunologic enhancement of rat renal allografts. III. Immunopathologic lesions and rejection in long-surviving passively enhanced grafts. (1/58)
Immunologic enhancement of renal allografts from (Lewis times Brown Norway) F1 to Lewis rats was achieved by administering a single dose of antidonor serum at the time of transplantation. A series of grafts functioning for 1 to 4 months after transplantation were examined by light and immunofluorescence microscopy to evaluate the long-term protective effects of the enhancing serum and to determine if previously unobserved lesions appeared in long survivors. Despite the absence of detectable circulating cytotoxic alloantibody, long-term allografts showed necrotizing glomerular and arterial lesions which resembled those seen in acutely rejecting grafts and were compatible with humoral rejection. Thus, in this model, there is a late decline in the ability of passive enhancement to inhibit humoral rejection. Long-term grafts also developed tubular lesions with deposition of immunoglobulin and complement on the tubular basement membranes (TBM). Anti-TBM antibodies were demonstrated in recipients' sera and found to be organ specific but not major histocompatibility antigen or species specific. This tubular lesion is therefore a unique form of allograft injury in which the immune response is directed against tissue antigen(s) which are distinct from the major histocompatibility antigens that induce rejection. (+info)Local infusion of urokinase and heparin into renal arteries in impending renal cortical necrosis. (2/58)
Two patients with presumed impending cortical necrosis, after haemolytic uraemic syndrome in one and after concealed accidental haemorrhage in the other, were treated by local infusion of urokinase and heparin into the renal artery. Both recovered and one regained normal renal function. Local infusion of anticoagulants or thrombolytic drugs into one renal artery offers the possibility of a controlled examination of the efficacy of this treatment in preventing cortical necrosis. (+info)Electron microscopic and cytochemical study of the vacuoles of regenerating renal tubular cells. (3/58)
The structure and acid phosphatase activity of vacuoles observed in regenerating proximal renal tubules were examined ultrastructurally. The sequestration and degradation of organelles were followed in the vacuoles, which obtain the acid phosphatase presumably from the lysosomes, and the limiting membrane of which originates from the endoplasmic reticulum. The vacuoles are regarded as autophagic vacuoles. Their appearance is correlated with the commencing differentiation of the dedifferentiated regenerating cells, which have similar regenerative phenomena. (+info)Histochemical examination of lysosomal exzymes in necrotic proximal renal tubules of albino rats. (4/58)
The lysosomal enzymatic activity of the necrotic proximal tubules was examined by light microscopy and electron microscopy in 24- and 48-h focal renal cortical necrosis induced by administration of oestrogen and posterior pituitary extract in rats. Organelles exhibiting acid phosphatase activity can also be seen in the necrotic cells but these differ in size and structure from the lysosomes of normal cells. The cytoplasmic nonspecific esterase and thioacetic acid hydrolase activities decrease considerably or disappear, although some morphologically damaged, but active, lysosomes can be observed. The role of thelysosomal enzymes is seen not in the development of the necrosis but rather in the breaking down of the already necrotic cell constituents. (+info)Experimental galactosamine-induced hepatitis. Effect of anticoagulant and antifibrinolytic agents on microclot formation. (5/58)
An experimental hepatitis was induced in rabbits by intravenous infusion of 1 g galactosamine per kilogram of body weight. Galactosamine administration caused microclot formation in kidneys, liver, lungs, and spleen in a low percentage. If, however, animals were infused with the fibrinolysis inhibitor epsilon-aminocaproic acid in addition to galactosamine, microclots were generated in a high percentage. The microclots exhibited typical staining characteristics like those observed in the generalized Shwartzman reaction. Some animals developed bilateral renal cortical necrosis. Heparin treatment prevented the occurrence of microclot fromation after galactosamine administration, but it neither prolonged the survival time of the animals nor prevented or reduced liver cell damage. Increases in serum GPT and bilirubin levels were similar in heparin-treated and untreated rabbits. The experiments indicate that disseminated intravascular coagulation is involved in galactosamine-induced hepatitis but does not contribute to the severity of the liver injury. (+info)Morphological changes induced in the pig kidney by extracorporeal shock wave lithotripsy: nephron injury. (6/58)
While shock wave lithotripsy (SWL) is known to cause significant damage to the kidney, little is known about the initial injury to cells along the nephron. In this study, one kidney in each of six juvenile pigs (6-7 weeks old) was treated with 1,000 shock waves (at 24 kV) directed at a lower pole calyx with an unmodified HM-3 lithotripter. Three pigs were utilized as sham-controls. Kidneys were fixed by vascular perfusion immediately after SWL or sham-SWL. Three of the treated kidneys were used to quantitate lesion size. Cortical and medullary samples for light (LM) and transmission electron microscopy (TEM) were taken from the focal zone for the shock waves (F2), the contralateral kidney, and the kidneys of sham-SWL pigs. Because preservation of the tissue occurred within minutes of SWL, the initial injury caused by the shock waves could be separated from secondary changes. No tissue damage was observed in contralateral sham-SWL kidneys, but treated kidneys showed signs of injury, with a lesion of 0.2% +/- 0.1% of renal volume. Intraparenchymal hemorrhage and injury to tubules was found at F2 in both the cortex and medulla of SWL-treated kidneys. Tubular injury was always associated with intraparenchymal bleeding, and the range of tissue injury included total destruction of tubules, focal cellular fragmentation, necrosis, cell vacuolization, and membrane blebbing. The initial injury caused by SWL was cellular fragmentation and necrosis. Cellular vacuolization, membrane blebbing, and disorganization of apical brush borders appear to be secondary changes related to hypoxia. (+info)Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. (7/58)
Neutrophil gelatinase-associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This complex converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney epithelial cells or accelerates their recovery from damage. Using a mouse model of severe renal failure, ischemia-reperfusion injury, we show that a single dose of Ngal (10 microg), introduced during the initial phase of the disease, dramatically protects the kidney and mitigates azotemia. Ngal activity depends on delivery of the protein and its siderophore to the proximal tubule. Iron must also be delivered, since blockade of the siderophore with gallium inhibits the rescue from ischemia. The Ngal:siderophore:Fe complex upregulates heme oxygenase-1, a protective enzyme, preserves proximal tubule N-cadherin, and inhibits cell death. Because mouse urine contains an Ngal-dependent siderophore-like activity, endogenous Ngal might also play a protective role. Indeed, Ngal is highly accumulated in the human kidney cortical tubules and in the blood and urine after nephrotoxic and ischemic injury. We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment. (+info)ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis. (8/58)
PURPOSE: Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is critical, but current detection methods relying upon clinical assessment, such as kidney biopsy and functional assays, are insufficient. We have developed a family of small molecule compounds, ApoSense, that is capable, upon systemic administration, of selectively targeting and accumulating within apoptotic/necrotic cells and is suitable for attachment of different markers for clinical imaging. The purpose of this study was to test the applicability of these molecules as a diagnostic imaging agent for the detection of renal tubular cell injury following renal ischemia. METHODS: Using both fluorescent and radiolabeled derivatives of one of the ApoSense compounds, didansyl cystine, we evaluated cell death in three experimental, clinically relevant animal models of ATN: renal ischemia/reperfusion, radiocontrast-induced distal tubular necrosis, and cecal ligature and perforation-induced sepsis. RESULTS: ApoSense showed high sensitivity and specificity in targeting injured renal tubular epithelial cells in vivo in all three models used. Uptake of ApoSense in the ischemic kidney was higher than in the non-ischemic one, and the specificity of ApoSense targeting was demonstrated by its localization to regions of apoptotic/necrotic cell death, detected morphologically and by TUNEL staining. CONCLUSION: ApoSense technology should have significant clinical utility for real-time, noninvasive detection of renal parenchymal damage of various types and evaluation of its distribution and magnitude; it may facilitate the assessment of efficacy of therapeutic interventions in a broad spectrum of disease states. (+info)Kidney cortex necrosis is a serious condition characterized by the death (necrosis) of cells in the outer part (cortex) of the kidneys, usually as a result of an interruption in blood flow. This can occur due to various reasons such as severe shock, blood clots, or complications from pregnancy. The necrosis of kidney cortical tissue can lead to acute renal failure, which is a life-threatening situation requiring immediate medical attention and intensive care.
The death of kidney cells in the cortex disrupts the normal functioning of the kidneys, impairing their ability to filter waste products and excess fluids from the blood. This can result in the accumulation of harmful substances in the body and an imbalance of electrolytes, which can be life-threatening if left untreated.
Kidney cortex necrosis is typically diagnosed through a combination of clinical evaluation, laboratory tests, and imaging studies such as ultrasound or CT scan. Treatment usually involves supportive care, including dialysis to replace the kidneys' function until they can recover on their own or until a transplant can be performed. In some cases, the damage to the kidneys may be permanent, leading to chronic renal failure and the need for long-term dialysis or transplantation.
The kidney cortex is the outer region of the kidney where most of the functional units called nephrons are located. It plays a crucial role in filtering blood and regulating water, electrolyte, and acid-base balance in the body. The kidney cortex contains the glomeruli, proximal tubules, loop of Henle, and distal tubules, which work together to reabsorb necessary substances and excrete waste products into the urine.
A kidney, in medical terms, is one of two bean-shaped organs located in the lower back region of the body. They are essential for maintaining homeostasis within the body by performing several crucial functions such as:
1. Regulation of water and electrolyte balance: Kidneys help regulate the amount of water and various electrolytes like sodium, potassium, and calcium in the bloodstream to maintain a stable internal environment.
2. Excretion of waste products: They filter waste products from the blood, including urea (a byproduct of protein metabolism), creatinine (a breakdown product of muscle tissue), and other harmful substances that result from normal cellular functions or external sources like medications and toxins.
3. Endocrine function: Kidneys produce several hormones with important roles in the body, such as erythropoietin (stimulates red blood cell production), renin (regulates blood pressure), and calcitriol (activated form of vitamin D that helps regulate calcium homeostasis).
4. pH balance regulation: Kidneys maintain the proper acid-base balance in the body by excreting either hydrogen ions or bicarbonate ions, depending on whether the blood is too acidic or too alkaline.
5. Blood pressure control: The kidneys play a significant role in regulating blood pressure through the renin-angiotensin-aldosterone system (RAAS), which constricts blood vessels and promotes sodium and water retention to increase blood volume and, consequently, blood pressure.
Anatomically, each kidney is approximately 10-12 cm long, 5-7 cm wide, and 3 cm thick, with a weight of about 120-170 grams. They are surrounded by a protective layer of fat and connected to the urinary system through the renal pelvis, ureters, bladder, and urethra.
Necrosis is the premature death of cells or tissues due to damage or injury, such as from infection, trauma, infarction (lack of blood supply), or toxic substances. It's a pathological process that results in the uncontrolled and passive degradation of cellular components, ultimately leading to the release of intracellular contents into the extracellular space. This can cause local inflammation and may lead to further tissue damage if not treated promptly.
There are different types of necrosis, including coagulative, liquefactive, caseous, fat, fibrinoid, and gangrenous necrosis, each with distinct histological features depending on the underlying cause and the affected tissues or organs.
The cerebral cortex is the outermost layer of the brain, characterized by its intricate folded structure and wrinkled appearance. It is a region of great importance as it plays a key role in higher cognitive functions such as perception, consciousness, thought, memory, language, and attention. The cerebral cortex is divided into two hemispheres, each containing four lobes: the frontal, parietal, temporal, and occipital lobes. These areas are responsible for different functions, with some regions specializing in sensory processing while others are involved in motor control or associative functions. The cerebral cortex is composed of gray matter, which contains neuronal cell bodies, and is covered by a layer of white matter that consists mainly of myelinated nerve fibers.
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine, a type of small signaling protein involved in immune response and inflammation. It is primarily produced by activated macrophages, although other cell types such as T-cells, natural killer cells, and mast cells can also produce it.
TNF-α plays a crucial role in the body's defense against infection and tissue injury by mediating inflammatory responses, activating immune cells, and inducing apoptosis (programmed cell death) in certain types of cells. It does this by binding to its receptors, TNFR1 and TNFR2, which are found on the surface of many cell types.
In addition to its role in the immune response, TNF-α has been implicated in the pathogenesis of several diseases, including autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, as well as cancer, where it can promote tumor growth and metastasis.
Therapeutic agents that target TNF-α, such as infliximab, adalimumab, and etanercept, have been developed to treat these conditions. However, these drugs can also increase the risk of infections and other side effects, so their use must be carefully monitored.
The prefrontal cortex is the anterior (frontal) part of the frontal lobe in the brain, involved in higher-order cognitive processes such as planning complex cognitive behavior, personality expression, decision making, and moderating social behavior. It also plays a significant role in working memory and executive functions. The prefrontal cortex is divided into several subregions, each associated with specific cognitive and emotional functions. Damage to the prefrontal cortex can result in various impairments, including difficulties with planning, decision making, and social behavior regulation.
The visual cortex is the part of the brain that processes visual information. It is located in the occipital lobe, which is at the back of the brain. The visual cortex is responsible for receiving and interpreting signals from the retina, which are then transmitted through the optic nerve and optic tract.
The visual cortex contains several areas that are involved in different aspects of visual processing, such as identifying shapes, colors, and movements. These areas work together to help us recognize and understand what we see. Damage to the visual cortex can result in various visual impairments, such as blindness or difficulty with visual perception.
Acute kidney injury (AKI), also known as acute renal failure, is a rapid loss of kidney function that occurs over a few hours or days. It is defined as an increase in the serum creatinine level by 0.3 mg/dL within 48 hours or an increase in the creatinine level to more than 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days, or a urine volume of less than 0.5 mL/kg per hour for six hours.
AKI can be caused by a variety of conditions, including decreased blood flow to the kidneys, obstruction of the urinary tract, exposure to toxic substances, and certain medications. Symptoms of AKI may include decreased urine output, fluid retention, electrolyte imbalances, and metabolic acidosis. Treatment typically involves addressing the underlying cause of the injury and providing supportive care, such as dialysis, to help maintain kidney function until the injury resolves.
Lypressin is a synthetic analogue of a natural hormone called vasopressin, which is produced by the pituitary gland in the brain. The primary function of vasopressin, also known as antidiuretic hormone (ADH), is to regulate water balance in the body by controlling the amount of urine produced by the kidneys.
Lypressin has similar physiological effects to vasopressin and is used in medical treatments for conditions related to the regulation of water balance, such as diabetes insipidus. Diabetes insipidus is a condition characterized by excessive thirst and the production of large amounts of dilute urine due to a deficiency in vasopressin or an impaired response to it.
In summary, Lypressin is a synthetic form of vasopressin, a hormone that helps regulate water balance in the body by controlling urine production in the kidneys. It is used as a therapeutic agent for treating diabetes insipidus and related conditions.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
Acute Kidney Tubular Necrosis (ATN) is a medical condition characterized by the death of tubular epithelial cells that make up the renal tubules of the kidneys. This damage can occur as a result of various insults, including ischemia (lack of blood flow), toxins, or medications.
In ATN, the necrosis of the tubular cells leads to a decrease in the kidney's ability to concentrate urine, regulate electrolytes and remove waste products from the body. This can result in symptoms such as decreased urine output, fluid and electrolyte imbalances, and the accumulation of waste products in the blood (azotemia).
Acute Kidney Tubular Necrosis is usually diagnosed based on clinical findings, laboratory tests, and imaging studies. Treatment typically involves supportive care, such as administering intravenous fluids to maintain hydration and electrolyte balance, managing any underlying conditions that may have contributed to the development of ATN, and providing dialysis if necessary to support kidney function until the tubular cells can recover.
Ischemia is the medical term used to describe a lack of blood flow to a part of the body, often due to blocked or narrowed blood vessels. This can lead to a shortage of oxygen and nutrients in the tissues, which can cause them to become damaged or die. Ischemia can affect many different parts of the body, including the heart, brain, legs, and intestines. Symptoms of ischemia depend on the location and severity of the blockage, but they may include pain, cramping, numbness, weakness, or coldness in the affected area. In severe cases, ischemia can lead to tissue death (gangrene) or organ failure. Treatment for ischemia typically involves addressing the underlying cause of the blocked blood flow, such as through medication, surgery, or lifestyle changes.
Renal cortical necrosis
Proximal tubule
Cephaloridine
Nephron
List of MeSH codes (C12)
Kidney (vertebrates)
Analgesic nephropathy
Adrenal tumor
Canine parvovirus
Actinobacillus equuli
Renal medulla
Renal ultrasonography
Pyelonephritis
Hydroxycarboxylic acid receptor 2
Vasa recta (kidney)
Adrenocortical carcinoma
Fusarium wilt
5-Oxo-eicosatetraenoic acid
Brain metastasis
Central neurogenic hyperventilation
Artificial cell
Renal cell carcinoma
Astrovirus
Astroviridae
Cholinergic anti-inflammatory pathway
Brain natriuretic peptide 32
Cortisol
Renal physiology
Murine respirovirus
Carbon monoxide poisoning
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Anabolic Steroids
Cortical19
- Renal cortical necrosis (RCN) is a rare cause of acute kidney failure. (wikipedia.org)
- Acute Thrombotic Microangiopathy and Cortical Necrosis Following Administration of Alemtuzumab: A Case Report. (wakehealth.edu)
- [4] Severe cases develop acute cortical necrosis affecting most cells in the renal cortex. (marlerblog.com)
- Cortical necrosis of the kidneys is the death of tissue in the outer layer (cortex) of one or both of your kidneys. (msdmanuals.com)
- Cortical necrosis is caused by a blockage of the blood vessels that bring blood to your kidneys. (msdmanuals.com)
- What causes cortical necrosis of the kidneys? (msdmanuals.com)
- What are the symptoms of cortical necrosis of the kidneys? (msdmanuals.com)
- How can doctors tell if I have cortical necrosis of the kidneys? (msdmanuals.com)
- Doctors suspect cortical necrosis if you have one of the disorders that can cause it and routine blood tests show your kidneys aren't working normally. (msdmanuals.com)
- How do doctors treat cortical necrosis of the kidneys? (msdmanuals.com)
- Doctors treat the problem that caused the cortical necrosis. (msdmanuals.com)
- Acute Renal Cortical Necrosis (ARCN) is characterized by the destruction of the renal cortex with poor prognosis. (ajsuccr.org)
- 11. Fernandez CP, Ripolles T, Martinez MJ, Blay J, Pallardo L, Gavela E. Diagnosis of acute cortical necrosis in renal transplantation by contrast-enhanced ultrasound: a preliminary experience. (acr.org)
- To evaluate the use of contrast-enhanced ultrasound (CEUS) for diagnosis of cortical necrosis in renal allografts. (acr.org)
- Each layer contains a complement of pyramidal, so- called Across species, greater cortical gyrification, or folding of the cortex, has been shown to be associated with higher cognitive abilities and is thought to reflect an problem for understanding the complex cortical integrative functions that underlie cognition. (netlify.app)
- 10 Aug 2020 Malformations of cortical development (MCD) comprise a large, heterogeneous group of disorders of disrupted cerebral cortex formation caused cortical irregularity(DFCI)이며(2-5), 내측 장딴지근( m e d i a l head of gastrocnemius muscle)이 대퇴골에 부착되는 부위에 생. (netlify.app)
- Next article Disorders of cortical formation are classified according to the embryologic stage of the cerebral cortex at which the abnormality occurred. (netlify.app)
- I investigate how the cerebral cortex may realise a number of basic computational av M Magnin · 2010 · Citerat av 168 - Thalamic and cortical activities are assumed to be time-locked Thus, asynchronous thalamo-cortical deactivation while falling asleep Many translated example sentences containing "cortical" - Swedish-English dictionary and search engine for Swedish translations. (netlify.app)
- Cortical: Having to do with the cortex, the outer layer of an organ. (netlify.app)
Tumor9
- Admixed with tumor cells there were multiple areas of hemorrhage, necrosis and thrombosis. (ufrgs.br)
- In most cases, there will be a solitary tumor in one kidney, but 5-13% of children have bilateral tumors and 10% have multifocal tumors in a single kidney. (medscape.com)
- In a study of ultrasound and laboratory findings in Wilms tumor survivors with a solitary kidney, signs of kidney damage were seen in 22 of 53 patients (41.5%) on ultrasonography. (medscape.com)
- The mass is of uniform echogenicity with a vague small central hypoechoic area suggestive of tumor necrosis. (medscape.com)
- An IVU shows a nonfunctioning left kidney with a suggestion of ill-defined mass in the left loin due to a biopsy-proven Wilms tumor. (medscape.com)
- The tumor is confined to the kidney, and it was completely excised. (medscape.com)
- The tumor extends beyond the kidney, but it was completely excised. (medscape.com)
- Once the microglia is activated by lipopolysaccharide, the affected microglia can produce a series of proinflammatory and cytotoxic factors, such as tumor necrosis factor- (TNF-) α and interleukin- (IL-) 1 β , which have been implicated in the neuropathogenesis of AD [ 13 ]. (hindawi.com)
- Western blot was used to quantify the expression of VE-cadherin, LC3II, and inflammatory factors (interleukin-1β, interleukin-6, and tumor necrosis factor-α) in kidney tissue, and enzyme-linked immunosorbent assay detected serum inflammatory factors and kidney function and early kidney injury biomarker levels. (scienceopen.com)
Cerebral cortex5
- In the cerebral cortex it was observed an extensive area of hemorrhage with adhered blood clot from frontal to temporal lobe. (ufrgs.br)
- In the cerebral cortex there was a focally extensive area of hemorrhage, multifocal thrombosis, abundant amount of gitter cells, and moderate perivascular inflammatory infiltrate of lymphocytes. (ufrgs.br)
- Bacterial examination was performed in fragments of cerebral cortex and kidney, and Staphylococcus pseudintermedius was isolated. (ufrgs.br)
- In this study, two causes which may have led to thromboembolism and cerebral hemorrhage are discussed: septicemia after invasion of lymphatic vessels by the anaplastic carcinoma or hypercoagulability caused by the systemic neoplasia, which could have reduce the blood flow to vessels of the cerebral cortex. (ufrgs.br)
- These RAS peptides are present in astrocytes, glial cells, oligodendrocytes, and neurons of various areas of the brain [ 14 , 15 ] such as the basal ganglia, cerebral cortex, and hippocampus [ 16 ]. (hindawi.com)
Tubular necrosis4
- The condition is "usually caused by significantly diminished arterial perfusion of the kidneys due to spasms of the feeding arteries, microvascular injury, or disseminated intravascular coagulation" and is the pathological progression of acute tubular necrosis. (wikipedia.org)
- Rapidly corrected acute renal ischemia leads to acute tubular necrosis, from which complete recovery is possible, while more prolonged ischemia may lead to RCN. (wikipedia.org)
- This map is developed to study chemical-induced nephrolithiasis (crystallopathy) and tubular necrosis in the ONTOX project. (disease-maps.org)
- Large tubular necrosis areas were seen only at 4 Gy dose, 1Gy/min dose rate and 48 h post-irradiation time that involved all tubules. (radioprotection.org)
Diseases7
- Saudi Journal of Kidney Diseases and Transplantation. (wikipedia.org)
- As seen in other kidney diseases, in STEC-HUS patients the progression to CKD is the consequence of renal mass reduction due to the loss of nephrons during the acute stage. (marlerblog.com)
- Kidney Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Kidney Diseases" by people in Harvard Catalyst Profiles by year, and whether "Kidney Diseases" was a major or minor topic of these publication. (harvard.edu)
- 7. The National Institute of Diabetes and Digestive and Kidney Diseases. (acr.org)
- Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
- Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Multifocal1
- Histopathologic examination of the liver showed multifocal necrosis and vacuolation of hepatocytes and infiltration by macrophages. (cdc.gov)
Interstitial nephritis2
Hemorrhage2
- Nonenhanced computed tomography (CT) scan in a 35-year-old woman with hypertension demonstrates a large, right-sided, inhomogeneous adrenal mass (white arrows) with a central area of low attenuation that represents hemorrhage or necrosis. (medscape.com)
- They are highly vascular (see the images below), and larger tumors are prone to hemorrhage and necrosis, even when they are benign. (medscape.com)
Tissue2
- Addison's disease also known as chronic adrenal insufficiency is a hormonal disorder characterized by tissue necrosis and granulomatous appearance. (targetwoman.com)
- The ingredients may otherwise cause local tissue necrosis and granuloma in the lungs. (who.int)
Perfusion3
- In general the renal cortex is under greater oxygen tension and more prone to ischemic injury, especially at the level of the proximal collecting tubule, leading to its preferential damage in a sudden drop in perfusion. (wikipedia.org)
- We observed the effect of ulinastatin in a septic rat model using contrast-enhanced ultrasonography (CEUS) to evaluate the perfusion of the renal cortex and medulla. (scienceopen.com)
- Ulinastatin effectively protects the adhesion junction and helps ameliorate the perfusion of kidney capillaries during sepsis by the inhibition of autophagy and the expression of inflammatory factors. (scienceopen.com)
Liver3
- Administration of anabolic steroids affects the metabolism and causes damage to vital organs such as heart, brain, kidneys and liver. (targetwoman.com)
- Simultaneously, CORT, as an adrenal cortex hormone, can even increase gluconeogenesis in liver cells. (ito-hosting.com)
- If you are older than 65 years , if your thyroid does not work properly (hypofunction), or if you suffer from a severe liver or kidney impairment, your doctor wil prescribe you a lower dose. (who.int)
Medulla1
- Pathologically, the cortex of the kidney is grossly atrophied with relative preservation of the gross structure of the medulla. (wikipedia.org)
Cause of acute1
- Hydronephrosis was detected in only 5% (42 of 810) of studies and in only 2.3% (19 of 810) of the cases was obstructive uropathy considered the cause of acute kidney injury. (acr.org)
Severe2
- Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. (biomedcentral.com)
- Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
Pyelonephritis2
- Striated nephrogram which is an appearance of gas in the renal area in emphysematous described for acute pyelonephritis shows discrete pyelonephritis or abscess and the typical mass like rays of alternating hypo attenuation and hyper calcification in end stage renal tuberculosis (Putty attenuation radiating from the papilla to the cortex kidney). (egyptianjournal.xyz)
- Pyelonephritis may manifest as wedge shaped zones tuberculosis, papillary necrosis and to evaluate of decreased attenuation or a hypodense mass in its congenital anomalies. (egyptianjournal.xyz)
Adrenal glands1
- They are released from the cortex of the adrenal glands located on top of the kidneys. (targetwoman.com)
Tubules4
- Degenerative changes in the glomeruli and tubules of the renal cortex. (wikidoc.org)
- The deposition of calcium always began at foci in the cytoplasm of the cells of the proximal convoluted tubules of the inner cortex. (rupress.org)
- The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
- 10 ] showed that the transplantation of mouse ESCs-derived RPCs can result in the stable integration into proximal tubules with normal morphology and normal polarization injection into developing live newborn mouse kidneys, suggesting the potential of ESCs for application in regenerative therapies. (biomedcentral.com)
Papillary1
- The role of intravenous urography (IVU) has diminished lately, however it still remains the best modality to diagnose calyceal irregularity of early tuberculosis, papillary necrosis and to evaluate congenital anomalies. (egyptianjournal.xyz)
Acute kidney2
- It is frequently associated with obstetric catastrophes such as abruptio placentae and septic shock, and is three times more common in developing nations versus industrialized nations (2% versus 6% in causes of acute kidney failure). (wikipedia.org)
- It accounts for 2% of all cases of acute kidney failure in adults and more than 20% of cases of acute kidney failure during late pregnancy. (wikipedia.org)
Histological1
- Histological staining was used to evaluate kidney injury scores. (scienceopen.com)
Pathological1
- Pathological processes of the KIDNEY or its component tissues. (harvard.edu)
Apoptosis3
- Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
- Recent studies have shown that in addition to necrosis and apoptosis, there are also other new programmed death modes, such as autophagy, necrosis and necrotic apoptosis, which have unique biological processes and pathophysiological characteristics. (nature.com)
- It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
Ultrasound2
Fragments1
- In order to describe radiation induced alterations of renal cell morphology, adult rats were whole-body exposed to 60-cobalt gamma rays at various doses (1, 2, or 4 Gy) and two dose rates (1 Gy/min or 1 Gy/h). 24 h or 48 h after irradiation, kidneys were take off and cortex fragments were fixed and embedded. (radioprotection.org)
Chronic kidney5
- Studies have shown that the selective non-steroidal MRA finerenone reduces the risk of cardiovascular events and chronic kidney disease (CKD) progression in individuals with CKD and type 2 diabetes mellitus. (gjmpbu.org)
- [ 2 ] Chronic kidney disease (CKD) often leads to many serious complications as end-stage renal disease and cardiovascular complication. (gjmpbu.org)
- To provide clinical practice guideline for the evaluation and management of chronic kidney disease (CKD). (acr.org)
- The usefulness of diagnostic testing in the initial evaluation of chronic kidney disease. (acr.org)
- Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician. (acr.org)
Autophagy1
- This is prone to show that atropine can enhance the activity of SRM to advertise the manufacturing of spermidine, and deal with oxidative stress, memory loss, and cell necrosis attributable to KYDS through bettering the body's autophagy. (ito-hosting.com)
Microvascular2
- They are found on epithelial, endothelial, mesangial, and glomerular cells of the kidney, as well as microvascular endothelial cells of the brain and intestine. (marlerblog.com)
- [ 1 ] The comorbidities associated with diabetes also need to be addressed as complications may affect both small and large blood vessels, leading to organ damage like kidney disease which is a major microvascular complication. (gjmpbu.org)
Ureter1
- Intrinsic obstructions (those that occur within the tract) include blood clots, stones, sloughed papilla along with tumours of the kidney, ureter and bladder. (wikidoc.org)
Damage1
- May indicate kidney damage. (vdocuments.net)
Fibrosis1
- PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis. (harvard.edu)
Disorder2
- While the only diagnostic "gold standard" mechanism of diagnosis en vivo is via kidney biopsy, the clinical conditions and blood clotting disorder often associated with this disease may make it impractical in a clinical setting. (wikipedia.org)
- Polycystic kidney disease in cats is a disorder characterized by the displacement of differentiated normal structures of renal parenchyma by multiple cysts. (vin.com)
Prognosis1
- The extent of the necrosis is a major determinant of the prognosis, which in turn is dependent on the duration of ischemia, duration of oliguria, and the severity of the precipitating conditions. (wikipedia.org)
Diabetes1
- The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. (harvard.edu)
Pale1
- The kidneys were pale with a fine speckling pattern over the cortex. (cdc.gov)
Biopsy1
- Exploring hospital practice types and their impact on glomerular pathologic patterns: Insights from the largest kidney biopsy cohort in Thailand. (harvard.edu)
Hydronephrosis1
- Specimen of a kidney that has undergone extensive dilation due to hydronephrosis. (wikidoc.org)
Organ2
- [2] Within the microvasculature of the kidney these clots disturb blood flow to the organ, causing acute kidney injury and kidney failure. (marlerblog.com)
- The kidney is the main target organ in STEC-mediated HUS. (marlerblog.com)
Right kidney2
- The scan shows a 6 x 8 cm solid mass at the lower pole of the right kidney displacing part of the collecting system in a cephalad direction. (medscape.com)
- The upper pole of the displaced right kidney can be seen (black arrow). (medscape.com)
Anuria1
- Here, we reported a Chinese female patient presenting abrupt anuria, acute kidney injury and heart failure. (ajsuccr.org)
Pole1
- Axial US image shows a solid 4.5-cm solid mass anterior cortex, lower pole of the left kidney. (medscape.com)
Spleen2
Abdominal1
- Kidneys palpated through the abdominal wall are enlarged and dented. (vin.com)
Infection1
- Infection may invade the whole kidney, leading to pyonephritis with capsular thickening (capsulite). (vin.com)
Bark2
- Willow bark might reduce blood flow through the kidneys. (medlineplus.gov)
- If you have kidney disease, don't use willow bark. (medlineplus.gov)
Rats1
- In contrast, the amount of calcification was correlated with the dose of uranium nitrate, being greatest in the kidneys of rats that received 20 mg./kg. (rupress.org)
Organs3
- From there, WBCs carry the toxin to the kidneys and other organs. (marlerblog.com)
- Because this attachment causes these organs to be susceptible to the toxicity of Shiga toxins, this distribution explains the involvement of the gut, kidney, and brain in STEC-associated hemolytic uremic syndrome (HUS). (marlerblog.com)
- Your kidneys are 2 bean-shaped organs that make urine (pee), balance your body's water and mineral levels, and filter waste out of your blood. (msdmanuals.com)
Profiles1
- Below are the most recent publications written about "Kidney Cortex Necrosis" by people in Profiles. (rush.edu)
Tissues1
- Inflammation of the connective and adipose tissues surrounding the KIDNEY. (umassmed.edu)
Cells4
- Ultrastructural lesions were observed in cortex kidneys 24 h after irradiation at 2 and 4 Gy doses and 1 Gy/min dose rate, displaying all features of apoptotic process mainly in PCT isolated cells. (radioprotection.org)
- Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
- In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
- However, progenitor cells in the adult kidney are rare, which limits the application of these cells. (biomedcentral.com)