Infections with bacteria of the genus KLEBSIELLA.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans.
A species of gram-negative bacteria causing URINARY TRACT INFECTIONS and SEPTICEMIA.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

Clindamycin plus gentamicin as expectant therapy for presumed mixed infections. (1/1262)

The prevalence of obligate anaerobes was studied prospectively in 60 patients with severe sepsis of intra-abdominal, soft tissue, female genital or oropulmonary origin. In addition, the efficacy of clindamycin (for anaerobes) plus gentamicin (for aerobic bacteria, especially coliforms) as initial empiric therapy in these patients was evaluated. Among 54 patients with cultural proof of infection, anaerobic pathogens were recovered from 52%. Nineteen patients had bacteremia; Bacteroides fragilis and Klebsiella pneumoniae were the most prevalent pathogens, being isolated in five patients each. Infection was eradicated in 56 of the 60 patients (93%). Mortality related to sepsis was 7% in the entire group, 16% in patients with bacteremia and 2% in patients without bacteremia. Eighty-five percent of aerobic isolates tested were susceptible in vitro to either gentamicin or clindamycin; 97% of anaerobic isolates were inhibited by 5 mug/ml of clindamycin.  (+info)

In-vitro selection of porin-deficient mutants of two strains of Klebsiella pneumoniae with reduced susceptibilities to meropenem, but not to imipenem. (2/1262)

We have evaluated the ability of imipenem and meropenem to select, in vitro, resistant mutants of two clinical isolates of Klebsiella pneumoniae producing both SHV and TEM beta-lactamases. Only meropenem selected mutants of both isolates for which the MICs of meropenem, but not imipenem, were markedly higher than those for the parent strains; the MICs of several other beta-lactam antibiotics, including beta-lactam/beta-lactamase inhibitor combinations, for these mutants were also higher than those for the parent strains. In contrast, the MICs for the imipenem-selected mutants were the same as, or similar to, those for the parent strains. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis revealed that an outer membrane protein in both parent strains was absent in the meropenem-selected mutants, but not in the imipenem-selected mutants. This protein is likely to be a porin, the absence of which is presumably associated with impaired beta-lactam permeability and, therefore, the reduced susceptibilities to these antibiotics exhibited by the mutant strains. We believe that this is the first report of the in-vitro selection of porin-deficient mutants of K. pneumoniae following exposure to meropenem.  (+info)

Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. (3/1262)

Lipoproteins are able to neutralize bacterial lipopolysaccharide (LPS) and thereby inhibit the proinflammatory cytokine response. In a previous study, we demonstrated that hypercholesterolemic low density lipoprotein receptor knock-out (LDLr-/-) mice are protected against lethal endotoxemia and gram-negative infection. In the present study we investigated the susceptibility of apolipoprotein E knock-out mice (apoE-/-) to LPS and to Klebsiella pneumoniae. These mice have increased plasma lipoprotein concentrations in the very low density lipoprotein (VLDL)-sized fraction. Despite 8 -fold higher plasma cholesterol levels compared to controls, and in contrast to LDLr-/- mice, apoE-/- mice were significantly more susceptible to endotoxemia and to K. pneumoniae infection. Circulating TNFalpha concentrations after intravenously injected LPS were 4 - to 5-fold higher in apoE-/- mice, whereas IL-1alpha, IL-1beta, and IL-6 did not differ. This TNF response was not due to an increased cytokine production capacity of cells from apoE-/- mice, as ex vivo cytokine production in response to LPS did not differ between apoE-/- and control mice. The LPS-neutralizing capacity of apoE-/- plasma was significantly less than that of controls. Most likely, the absence of apoE itself in the knock-out mice explains the failure to neutralize LPS, despite the very high cholesterol concentrations.  (+info)

Short-course ceftriaxone therapy in spontaneous bacterial peritonitis. (4/1262)

Forty patients with spontaneous bacterial peritonitis, three of whom had complicating acute hepatitis syndrome, eight late-onset hepatic failure, and 29 with cirrhosis, were treated with ceftriaxone 2 g intravenously once daily for 5 days. Ascitic fluid culture was positive in 28 patients, with Escherichia coli and Klebsiella as common isolates. All the bacteria isolated were sensitive to ceftriaxone except Enterococcus faecalis, which was isolated in a cirrhotic patient. All culture-positive patients sensitive to ceftriaxone showed bacteriological cure and 26 (65%) patients showed cytological cure after 48 hours of treatment. A total of 95% were cured of their infection after 5 days of treatment. Twelve (30%) patients died during hospitalisation after documented cure of their spontaneous bacterial peritonitis (renal failure, gastrointestinal bleed and cerebral oedema were the primary causes of death). Infection-related mortality due to Pseudomonas septicaemia was seen in one cirrhotic patient.  (+info)

Porin expression in clinical isolates of Klebsiella pneumoniae. (5/1262)

Two porins, OmpK36 and OmpK35, have been described previously in Klebsiella pneumoniae, and they are homologous to the Escherichia coli porins OmpC and OmpF, respectively, at both the DNA and amino acid levels. Optimal resolution of the two K. pneumoniae porins by electrophoresis on polyacrylamide gels is not achieved using gel systems already described for E. coli and requires modifications of the bisacrylamide content of the resolving gels. Once resolved, identification of porins OmpK36 and OmpK35 cannot be based solely on their apparent molecular masses since in some strains the OmpK36 porin migrates faster than the OmpK35 porin, whilst in other strains OmpK35 is the faster-migrating porin. Expression of OmpK35 porin is increased in low-osmolarity medium and, combined with Western blot analysis, this allows for the identification of both porins. Application of this identification system showed that most isolates lacking expression of extended-spectrum beta-lactamases express the two porins, whereas most isolates producing these beta-lactamases express only porin OmpK36, and the OmpK35 porin is either very low or not expressed.  (+info)

Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area. (6/1262)

Two beta-lactamase gene regions were characterized by DNA sequencing in eight clinical isolates of Klebsiella oxytoca. The blaOXY-2a region encoded a beta-lactamase nearly identical to OXY-2 (one amino acid residue substituted) and conferred aztreonam and cefuroxime resistance on the K. oxytoca isolates. Overproduction of OXY-2a was caused by a G-to-A substitution of the fifth nucleotide in the -10 consensus sequence of blaOXY-2a. The blaOXY-1a was identified in a susceptible strain, and the OXY-1a enzyme differed from OXY-1 by two amino acid residues.  (+info)

Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea. (7/1262)

Two hundred ninety isolates of Escherichia coli were investigated for the production of extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) of the 290 strains were found to produce ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs of ceftazidime and cefoxitin were high, were probable AmpC enzyme hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic relatedness among the organisms, ribotyping of TEM-52-producing E. coli and K. pneumoniae was performed. The ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea.  (+info)

Outbreak of extended spectrum beta lactamase producing Klebsiella pneumoniae in a neonatal unit. (8/1262)

An outbreak of extended spectrum beta lactamase producing Klebsiella pneumoniae (ESBLKp) in a neonatal unit was controlled using simple measures. Normally, the control of such infections can be time consuming and expensive. Seven cases of septicaemia resulted in two deaths. ESBLKp isolates were subtyped by pulsed field gel electrophoresis, and four of the five isolates typed were identical. Control of the outbreak was achieved by altered empiric antibiotic treatment for late onset sepsis and prevention of cross infection by strict attention to hand washing. Widespread colonisation of babies in the unit was presumed, so initial surveillance cultures were not performed. No further episodes of sepsis occurred.  (+info)

Klebsiella infections are caused by bacteria called Klebsiella spp., with the most common species being Klebsiella pneumoniae. These gram-negative, encapsulated bacilli are normal inhabitants of the human gastrointestinal tract and upper respiratory tract but can cause various types of infections when they spread to other body sites.

Commonly, Klebsiella infections include:

1. Pneumonia: This is a lung infection that can lead to symptoms like cough, chest pain, difficulty breathing, and fever. It often affects people with weakened immune systems, chronic lung diseases, or those who are hospitalized.

2. Urinary tract infections (UTIs): Klebsiella can cause UTIs, particularly in individuals with compromised urinary tracts, such as catheterized patients or those with structural abnormalities. Symptoms may include pain, burning during urination, frequent urges to urinate, and lower abdominal or back pain.

3. Bloodstream infections (bacteremia/septicemia): When Klebsiella enters the bloodstream, it can cause bacteremia or septicemia, which can lead to sepsis, a life-threatening condition characterized by an overwhelming immune response to infection. Symptoms may include fever, chills, rapid heart rate, and rapid breathing.

4. Wound infections: Klebsiella can infect wounds, particularly in patients with open surgical wounds or traumatic injuries. Infected wounds may display redness, swelling, pain, pus discharge, and warmth.

5. Soft tissue infections: These include infections of the skin and underlying soft tissues, such as cellulitis and abscesses. Symptoms can range from localized redness, swelling, and pain to systemic symptoms like fever and malaise.

Klebsiella infections are increasingly becoming difficult to treat due to their resistance to multiple antibiotics, including carbapenems, which has led to the term "carbapenem-resistant Enterobacteriaceae" (CRE) or "carbapenem-resistant Klebsiella pneumoniae" (CRKP). These infections often require the use of last-resort antibiotics like colistin and tigecycline. Infection prevention measures, such as contact precautions, hand hygiene, and environmental cleaning, are crucial to controlling the spread of Klebsiella in healthcare settings.

Klebsiella is a genus of Gram-negative, facultatively anaerobic, encapsulated, non-motile, rod-shaped bacteria that are part of the family Enterobacteriaceae. They are commonly found in the normal microbiota of the mouth, skin, and intestines, but can also cause various types of infections, particularly in individuals with weakened immune systems.

Klebsiella pneumoniae is the most common species and can cause pneumonia, urinary tract infections, bloodstream infections, and wound infections. Other Klebsiella species, such as K. oxytoca, can also cause similar types of infections. These bacteria are resistant to many antibiotics, making them difficult to treat and a significant public health concern.

"Klebsiella pneumoniae" is a medical term that refers to a type of bacteria belonging to the family Enterobacteriaceae. It's a gram-negative, encapsulated, non-motile, rod-shaped bacterium that can be found in various environments, including soil, water, and the gastrointestinal tracts of humans and animals.

"Klebsiella pneumoniae" is an opportunistic pathogen that can cause a range of infections, particularly in individuals with weakened immune systems or underlying medical conditions. It's a common cause of healthcare-associated infections, such as pneumonia, urinary tract infections, bloodstream infections, and wound infections.

The bacterium is known for its ability to produce a polysaccharide capsule that makes it resistant to phagocytosis by white blood cells, allowing it to evade the host's immune system. Additionally, "Klebsiella pneumoniae" has developed resistance to many antibiotics, making infections caused by this bacterium difficult to treat and a growing public health concern.

"Klebsiella oxytoca" is a species of Gram-negative, facultatively anaerobic, rod-shaped bacteria that is part of the family Enterobacteriaceae. It is a normal inhabitant of the human gastrointestinal tract and can be found in soil, water, and plants. In clinical settings, K. oxytoca can cause various types of infections, including pneumonia, bloodstream infections, wound infections, and urinary tract infections. It is known to produce a variety of beta-lactamases, enzymes that can hydrolyze and inactivate certain antibiotics, making it resistant to some forms of treatment. Its identification is important for appropriate antimicrobial therapy and infection control measures.

Beta-lactamases are enzymes produced by certain bacteria that can break down and inactivate beta-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. This enzymatic activity makes the bacteria resistant to these antibiotics, limiting their effectiveness in treating infections caused by these organisms.

Beta-lactamases work by hydrolyzing the beta-lactam ring, a structural component of these antibiotics that is essential for their antimicrobial activity. By breaking down this ring, the enzyme renders the antibiotic ineffective against the bacterium, allowing it to continue growing and potentially causing harm.

There are different classes of beta-lactamases (e.g., Ambler Class A, B, C, and D), each with distinct characteristics and mechanisms for breaking down various beta-lactam antibiotics. The emergence and spread of bacteria producing these enzymes have contributed to the growing problem of antibiotic resistance, making it increasingly challenging to treat infections caused by these organisms.

To overcome this issue, researchers have developed beta-lactamase inhibitors, which are drugs that can bind to and inhibit the activity of these enzymes, thus restoring the effectiveness of certain beta-lactam antibiotics. Examples of such combinations include amoxicillin/clavulanate (Augmentin) and piperacillin/tazobactam (Zosyn).

... is a nosocomial, pathogenic bacterium that causes opportunistic infections of most types. Infections are ... Enterobacter Infections at eMedicine "Klebsiella aerogenes". NCBI Taxonomy Browser. 548. Type strain of Klebsiella aerogenes at ... Some infections caused by K. aerogenes result from specific antibiotic treatments, venous catheter insertions, and/or surgical ... Klebsiella aerogenes, previously known as Enterobacter aerogenes, is a Gram-negative, oxidase-negative, catalase-positive, ...
Klebsiella oxytoca, which can cause urinary tract infections; Aspergillus niger, which creates aflatoxins that can lead to ... Although these pathogens and fungi utilize the wasp's detritus, it becomes a problem for people as they can lead to infection, ... Similar to D. adulterina invasions, the earlier the host's nest is infected, the more effective the infection. Rather than ... and Klebsiella oxytoca. Fungi are also found, including Aspergillus niger and Candida krusei. ...
Infections with carbapenem-resistant Klebsiella pneumoniae were associated with organ/stem cell transplantation, mechanical ... A 2008 study at Mount Sinai identified outcomes associated with Carbapenem-resistant Klebsiella pneumoniae infections, in which ... "Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies". ... "Outcomes of Carbapenem-Resistant Klebsiella pneumoniae Infection and the Impact of Antimicrobial and Adjunctive Therapies". ...
Klebsiella Infection (emedicine.com) Klebsiella Genome Projects from Genomes OnLine Database Klebsiella pneumoniae-Associated ... "Klebsiella species - GOV.UK". www.gov.uk. Retrieved 13 January 2017. Klebsiella Infections at eMedicine Li B, Zhao Y, Liu C, ... To prevent spreading Klebsiella infections between patients, healthcare personnel must follow specific infection-control ... O antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections. ...
He observed a similar reduction of the less frequent Klebsiella, Proteus-dominant infections. A quantitative bacteriological ... Reid G, Burton J (March 2002). "Use of Lactobacillus to prevent infection by pathogenic bacteria". Microbes and Infection. 4 (3 ... These include (chronic) upper genital tract infections, urinary tract infections and cervical dysplasias. The prophylactic use ... upper genital tract infection (5) urinary tract infection (6) infertility (7) genital lesions and tumors (8) trichomoniasis ...
The majority of human Klebsiella infections are caused by K. pneumoniae, followed by K. oxytoca. Infections are more common in ... urinary tract infections, sepsis, meningitis, diarrhea, peritonitis and soft tissue infections. Klebsiella species have also ... Ristucci, Patricia; Cunha, Burke (July 1984). "Klebsiella". Infection Control. 5 (7): 343-348. doi:10.1017/S0195941700060549. ... Klebsiella is named after German-Swiss microbiologist Edwin Klebs (1834-1913). Carl Friedlander described Klebsiella bacillus ...
Klebsiella granulomatis infection is most popularly known as "donovanosis" in medical community. University College Cork (was ... The scientific name was ultimately changed to Klebsiella granulomatis based on the phylogenetic relationship with the genus ... Richens, John (2006). "Donovanosis and Klebsiella spp.". In Stephen Gillespie; Peter M. Hawkey (eds.). Principles and Practice ... O'Farrell, N (2002). "Donovanosis". Sexually Transmitted Infections. 78 (6): 452-457. doi:10.1136/sti.78.6.452. PMC 1758360. ...
May 2013). "SPLUNC1/BPIFA1 Contributes to Pulmonary Host Defense against Klebsiella pneumoniae Respiratory Infection". The ... January 2013). "Multifunctional Role of Human SPLUNC1 in Pseudomonas aeruginosa Infection". Infection and Immunity. 81 (1): 285 ... By lowering the surface tension in mucosal fluids, BPIFA1/SPLUNC1 inhibits bacteria like Klebsiella from proliferating as a ...
"Yersinia bactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection". Infection and Immunity. 75 (3): ... "Identification of Klebsiella pneumoniae virulence determinants using an intranasal infection model: Klebsiella pneumoniae ... "Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB/c mouse model of infection". Infection and ... She has also worked on how Salmonella and Klebsiella pneumoniae cause disease.In brief, she mostly worked in the areas of ...
... has been effective in treating infections caused by Pseudomonas, Escherichia, and Klebsiella species. The following ... which mapped 13 colistin-resistant infections recorded over 18 months. It concluded that pan-drug-resistant infections, ... For systemic infection, colistin must therefore be given by injection. Colistimethate is eliminated by the kidneys, but ... Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used in ...
Pathogenic bacteria responsible for the infection include E. coli, Klebsiella, Pseudomonas, and Proteus species. Anaerobes are ... The formation of calcium bilirubinate stones in RPC has been attributed to a high incidence of infection with Escherichia coli ... With resistant infection, a surgical hepatectomy or hepaticocutaneousjejunostomy can be performed. Lifelong surveillance for ... Traits that raise suspicion for the infection include intra- and extra- hepatic dilatation and strictures with intraductal ...
"Lyn regulates inflammatory responses in Klebsiella pneumonia infection via the p38/NF-kB pathway". Eur. J. Immunol. 44 (3): 763 ... Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): ... evidence suggest that lyn activation in alveolar phagocytes improves phagocytosis of bacteria and reduces pulmonary infection. ...
... cerebritis may occur as a result of a Klebsiella pneumoniae infection. One other reason to develop cerebritis is an infection ... When it is caused by infections, treatment consists of medication that will primarily cure the infection. For inflammation, ... Infections can occur when infectious agents enter the brain through the sinuses or as a result of trauma. Some pathogens are ... It is also defined as a purulent nonencapsulated parenchymal infection of brain which is characterized by nonspecific features ...
... is used to treat adults with complicated urinary tract infections, including kidney infections caused by ... Klebsiella specie. and Acinetobacter baumannii) who had been treated in Germany. Its structure is similar to cefepime and ... The cause of death has not been established, but some of the deaths were a result of worsening or complications of infection, ... As of 2020, cefiderocol is indicated in the European Union for the treatment of infections due to aerobic Gram-negative ...
Schembri MA, Blom J, Krogfelt KA, Klemm P (August 2005). "Capsule and fimbria interaction in Klebsiella pneumoniae". Infection ... "Role of bacterial capsule in local and systemic inflammatory responses of mice during pulmonary infection with Klebsiella ... Dorman MJ, Feltwell T, Goulding DA, Parkhill J, Short FL (November 2018). "Klebsiella pneumoniae Defined by density-TraDISort ... Infection and Immunity. 86 (3). doi:10.1128/IAI.00802-17. PMC 5820961. PMID 29311231. Hyams C, Camberlein E, Cohen JM, Bax K, ...
1) Compared to control mice, Ffar2 gene knockout mice had more severe infections in models of Citrobacter rodentium, Klebsiella ... "The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung". Frontiers in ... at the infection sites or, in urinary tract infections, the urine. These SCFAs may be made and released by the bacteria and/or ... A New Option for Treating Infections?". Frontiers in Cellular and Infection Microbiology. 11: 785833. doi:10.3389/fcimb. ...
In experiments, it cured mice of infections with Escherichia coli and Klebsiella pneumoniae, both members of the ...
... bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella ... 1 January - Israel reports, for the first time, a case of flurona, a rare mixture of coronavirus and influenza infections. 3 ... "Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection - California, ... Doctors report that an antiseptic drug reduced recurring urinary tract infections in a trial as effectively as antibiotics ...
... bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella ... In the months after, she lost her stomach and spleen due to a life-threatening antibiotic-resistant bacterial infection. An ... Domínguez, Nuño (27 January 2022). "How a virus helped a woman survive a dangerous antibiotic-resistant infection". EL PAÍS ... experimental treatment with a bacteriophage eventually cured the infection. The scientific journal Nature published an article ...
... bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella ... Biofilm infections are very challenging to treat with antibiotics. The biofilm matrix and surrounding bacterial membranes can ... PhagoBurn, a phase-1 and 2 trial of phage therapy against P. aeruginosa wound infection in France and Belgium in 2015-17, was ... These factors make phage therapy an enticing option for the treatment of such infections, and there are currently two ways to ...
... to cause urinary tract infection. Klebsiella and Proteus spp., are frequently associated with stone disease. The presence of ... persistent infections (infection with the same pathogen), a re-infection (new pathogen), or a relapsed infection (the same ... Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection. Diagnosis ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract ...
The infection was identified as a carbapenem-resistant Klebsiella pneumoniae strain bearing the novel gene blaNDM-1. The ... In September 2016, a 70-year-old woman in Reno, Nevada, died of septic shock following infection with NDM-producing Klebsiella ... The class A Klebsiella pneumoniae carbapenemase (KPC) is currently the most common carbapenemase, which was first detected in ... In May 2010, a case of infection with E. coli expressing NDM-1 was reported in Coventry in the United Kingdom. The patient was ...
... and infection with Klebsiella oxytoca. In some patients, overgrowth of Klebsiella oxytoca has been shown to result in AAHC due ... Previous work has shown that PBD tilivalline produced by Klebsiella oxytoca was linked to the pathogenesis of colitis in animal ... "Klebsiella oxytoca as a Causative Organism of Antibiotic-Associated Hemorrhagic Colitis". New England Journal of Medicine. 355 ... "Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing ...
... knockout mice are more susceptible to the development and pathological complications of experimental infection with Klebsiella ... "5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice". Infection and Immunity. 83 (3): ... Basil MC, Levy BD (2016). "Specialized pro-resolving mediators: endogenous regulators of infection and inflammation". Nature ... Trypanosoma cruzi infection. Furthermore, Alox5-null mice exhibit a worsened inflammatory component, failure to resolve ...
He is known for his research on healthcare related infections with special emphasis on Acinetobacter, Klebsiella, ESKAPE, Human ... Srinivasan, Vijaya Bharathi; Rajamohan, Govindan (1 September 2013). "KpnEF, a New Member of the Klebsiella pneumoniae Cell ... produced by Klebsiella pneumoniae strain MGH78578". FEBS Letters. 586 (21): 3778-3786. doi:10.1016/j.febslet.2012.09.007. ISSN ... "Role of the Two Component Signal Transduction System CpxAR in Conferring Cefepime and Chloramphenicol Resistance in Klebsiella ...
... can be used to treat bacterial infections in animals caused by Escherichia coli, Klebsiella pneumoniae, and ... Klebsiella pneumoniae - 2 μg/mL - >256 μg/mL Pseudomonas aeruginosa - 4 μg/mL Ryden R, Moore BJ (November 1977). "The in vitro ...
An estimated more than 20% of the Klebsiella infections in Brooklyn hospitals "are now resistant to virtually all modern ... In the US, the most frequent type of hospital infection is urinary tract infection (36%), followed by surgical site infection ( ... infections of surgery site (14.2%). Infections of the skin and mucous membrane (10.2%), other respiratory infections (6.8%) and ... Nosocomial infections can cause severe pneumonia and infections of the urinary tract, bloodstream and other parts of the body. ...
"Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae: Risk Factors for Infection and Impact of ... When a gram-negative bacterial infection is suspected in a patient, one of the first-line options for treatment is in the ... For example, of the two million people affected by resistant infections a year, 23,000 will die. Severity in mortality is ... Other issues are associated with duration and complexity of infection. On average, treatment for non-resistant bacteria is ...
Urinary tract infections, including prostatitis, caused by E. coli, P. mirabilis and Klebsiella species. Cefradine is ... Respiratory tract infections (such as tonsillitis, pharyngitis, and lobar pneumonia) caused by group A beta-hemolytic ... Skin and skin structure infections caused by staphylococci (penicillin-susceptible and penicillin-resistant) and beta-hemolytic ... Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis ...
doi:10.1016/S0304-5412(14)70733-4. Dixit P, Kotra LP (January 2007). "Calymmatobacterium Granulomatis Infections". In Enna SJ, ... Klebsiella granulomatis is Gram-negative, rod-shaped bacterium of the genus Klebsiella known to cause the sexually transmitted ... Stoner BP (2018-01-01). "Klebsiella granulomatis: Granuloma Inguinale". In Long SS, Prober CG, Fischer M (eds.). Principles and ... 1-4. doi:10.1016/b978-008055232-3.60880-3. ISBN 978-0-08-055232-3. "Klebsiella granulomatis". NCBI Taxonomy Browser. 39824. v t ...
The genus Klebsiella belongs to the tribe Klebsiellae, a member of the family Enterobacteriaceae. The organisms are named after ... encoded search term (Klebsiella Infections) and Klebsiella Infections What to Read Next on Medscape ... Klebsiella pneumoniae, Klebsiella oxytoca, and Klebsiella granulomatis. Organisms previously known as Klebsiella ozaenae and ... Klebsiella Infections. Updated: Dec 07, 2022 * Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD more ...
Invasive infection with hypermucoviscous Klebsiella pneumoniae: multiple cases presenting to a single emergency department in ... McCabe R, Lambert L, Frazee B. Invasive Klebsiella pneumoniae Infections, California, USA. Emerging Infectious Diseases. 2010; ... To the Editor: A distinctive form of tissue-invasive community-associated Klebsiella pneumoniae infection, typified by primary ... McCabe, R., Lambert, L., & Frazee, B. (2010). Invasive Klebsiella pneumoniae Infections, California, USA. Emerging Infectious ...
The genus Klebsiella belongs to the tribe Klebsiellae, a member of the family Enterobacteriaceae. The organisms are named after ... encoded search term (Klebsiella Infections) and Klebsiella Infections What to Read Next on Medscape ... Klebsiella Infections Clinical Presentation. Updated: Dec 07, 2022 * Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael ... Epidemiological study of klebsiella infection in the special care baby unit of a London hospital. J Clin Pathol. 1980 Apr. 33(4 ...
Capsule is an important virulence factor for Klebsiella pneumoniae and infections due to this pathogen have been associated ... h post infection during acute lung infection and 6 h later during septicemia. Bacterial load, neutrophil infiltration and ... Bacterial load (Log 10 CFU/ml) 24 h post infection in various organs and blood of mice infected via intraperitoneal route with ...
... and mobile genetic elements of carbapenem-resistant Klebsiella pneumoniae causing infections in Chile. Marcelo Veloso, Joaquín ... González Rocha G, Vera Leiva A, Barría Loaiza C, Carrasco Anabalón S, Lima C, Aguayo Reyes A, et al. KPC: Klebsiella pneumoniae ... David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae ... Gomez SA, Pasteran FG, Faccone D, Tijet N, Rapoport M, Lucero C, et al. Clonal dissemination of Klebsiella pneumoniae ST258 ...
P105 Treatment of the lower gastrointestinal tract Klebsiella infections by recombinant bacteriocin KvarIa Karaliute, I.(1); ... Faecal and tissue samples were used for Klebsiella haemolysin gene (khe) analysis using RT-PCR. ... Hospital-acquired infections (HAI) are one of the leading worldwide health care issues. The most prevalent HAI are the ... quasipneumoniae infection. Four study groups were used (3 animals/group) to test the antimicrobial efficacy of orally delivered ...
... and Serratia Infections - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer ... or kidney infections Kidney Infection Pyelonephritis is a bacterial infection of one or both kidneys. Infection can spread up ... bladder infections Bladder Infection Cystitis is infection of the bladder. Usually, bacteria are the cause of cystitis. A ... Klebsiella, Enterobacter, and Serratia Infections By Larry M. Bush , MD, FACP, Charles E. Schmidt College of Medicine, Florida ...
Degradable antimicrobial polycarbonates with unexpected activity and selectivity for treating multidrug-resistant Klebsiella ... pneumoniae lung infection in mice for Acta Biomaterialia by Chuan Yang et al. ... Multidrug resistant (MDR) Klebsiella pneumoniae is a major cause of healthcare-associated infections around the world, with ... In this study, the structures of the polymers were optimized for the treatment of MDR Klebsiella pneumoniae lung infection. ...
Klebsiella pneumoniae; Infecções por Klebsiella/tratamento farmacológico; Infecções por Klebsiella/epidemiologia; Estudos ... Mortality in KPC-producing Klebsiella pneumoniae bloodstream infections: a changing landsc Mortality in KPC-producing ... To assess the impact of carbapenem resistance on mortality in Klebsiella pneumoniae bloodstream infection (BSI) in the era of ... Klebsiella pneumoniae bloodstream infections: a changing landscape. Giacobbe, Daniele Roberto; Marelli, Cristina; Cattardico, ...
Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. ... The infection cannot be related to any other infection the patient might have and must not have been present or incubating when ... Central line--associated blood stream infections (CLABSIs) are serious but preventable infections. ... TABLE 2. Estimated annual number of central line--associated blood stream infections (CLABSIs), by health-care setting and year ...
METHODS: We used Klebsiella pneumoniae (K.p.) in a murine lung infection model to determine if pulmonary bacterial clearance is ... Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model. ... Thus, exposure to Cu NPs may increase the risk of pulmonary infection. ... exposed mice measured 24 hr after bacterial infection following Cu NP exposure versus sham-exposed mice also challenged with K. ...
... Catheter-associated Urinary Tract Infections ... Nosocomial Klebsiella infections: intestinal colonization as a reservoir. Ann Intern Med 1971;74:657-64. * McLeod JW. The ... Catheter-associated urinary tract infections are caused by a variety of pathogens, including Escherichia coli, Klebsiella, ... When cross-infection is likely to be responsible for the spread of catheter-associated infections, additional measures have ...
... and Klebsiella. Of note, candidal infections may not always produce visible lesions. [54] ... Oral infection has been explored, and a few microbes have been identified to be potentially more prevalent in burning mouth ... Ozkan BT, Celik S, Durmus E. Paresthesia of the mental nerve stem from periapical infection of mandibular canine tooth: a case ... What is the role of infection in the etiology of burning mouth syndrome (BMS)? ...
Return to Article Details EPIDEMIOLOGY OF CARBAPENEM RESISTANT KLEBSIELLA PNEUMONIAE INFECTIONS IN MEDITERRANEAN COUNTRIES ...
"Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents." J Infect Dis, vol. 197, no. 5, Mar. 2008, ... "Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents." J Infect Dis 197, no. 5 (March 1, 2008): ... Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents.. Publication , Journal Article ... Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents. J Infect Dis. 2008 Mar 1;197(5):752-6. ...
Return to Article Details Bloodstream Infections by Extended-spectrum β-lactamase-producing Klebsiella Species in Children ...
Colistin-resistant Klebsiella infections documented at Indian hospital. Originally published by CIDRAP News Oct 24 ... A new study in Infection Control and Hospital Epidemiology describes several cases of colistin-resistant Klebsiella pneumoniae ... Small study finds brain alterations after COVID Omicron infection After infection, anxiety scores were significantly higher, ... H pylori infection causes inflammation of the stomach lining and can lead to peptic ulcers. The bacteria is also associated ...
Klebsiella aerogenes is a nosocomial, pathogenic bacterium that causes opportunistic infections of most types. Infections are ... Enterobacter Infections at eMedicine "Klebsiella aerogenes". NCBI Taxonomy Browser. 548. Type strain of Klebsiella aerogenes at ... Some infections caused by K. aerogenes result from specific antibiotic treatments, venous catheter insertions, and/or surgical ... Klebsiella aerogenes, previously known as Enterobacter aerogenes, is a Gram-negative, oxidase-negative, catalase-positive, ...
... we describe a community-acquired invasive infection caused by a ST66-K2 Kp strain in France. Four hypermucoviscous Kp isolates ... We report the first case of community-acquired infection caused by a hypervirulent ST66-K2 Kp strain in Europe. This ... reference strain Kp52.145 is widely used in experimental Klebsiella pathophysiology. Since 1935, only one other strain of the ... Community-acquired infection caused by the uncommon hypervirulent Klebsiella pneumoniae ST66-K2 lineage * Carla Rodrigues1​,†. ...
An outbreak of infection due to beta-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek ... Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil. Brazilian Journal of ... Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infections. Diagnostic Microbiology and ... Detection of Klebsiella pneumoniae carbapenemase (KPC) production in non-Klebsiella pneumoniae Enterobacteriaceae isolates by ...
Molecular epidemiology of Escherichia coli and Klebsiella species bloodstream infections in Oxfordshire (UK) 2008-2018 ... Molecular epidemiology of Escherichia coli and Klebsiella species bloodstream infections in Oxfordshire (UK) 2008-2018 ...
Klebsiella Infections; Klebsiella pneumoniae; Male; Neoplasms; Premature Birth; Taiwan. [SDGs]SDG3. Appears in Collections:. 醫學 ... Infections of cefotaxime-resistant and cefmetazole-susceptible Escherichia coli and Klebsiella pneumoniae in children. ... Gram negative infection; heart failure; human; immune deficiency; infant; infantile spasm; intensive care unit; Klebsiella ... Before the acquisition of the infection, a history of stay in an intensive care unit within 4 weeks was noted in 10 cases (71.4 ...
A case of treatment of multidrug-resistant intracranial Klebsiella pneumoniae infection by multichannel colistin sulfate - ... colistin sulfateintracranial infectionintrathecalKlebsiella pneumoniaemultidrug-resistant Gram-negative infections ... Themanagement of severe neurologic infections due to multidrug-resistant (MDR) Klebsiella pneumoniae infection remains a ... A case of treatment of multidrug-resistant intracranial Klebsiella pneumoniae infection by multichannel colistin sulfate - ...
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Alcohol Induced Diabetic Ketoacidosis Exacerbated by an Acute Respiratory Infection with Klebsiella pneumoniae. Caleb Distel, ... Alcohol Induced Diabetic Ketoacidosis Exacerbated by an Acute Respiratory Infection with Klebsiella pneumoniae ... Alcohol Induced Diabetic Ketoacidosis Exacerbated by an Acute Respiratory Infection with Klebsiella pneumoniae ... Alcohol Induced Diabetic Ketoacidosis Exacerbated by an Acute Respiratory Infection with Klebsiella pneumoniae ...
... pneumoniae infections. The hallmark of HVKp infections are liver abscess formation and metastatic infections. Due to the severe ... Simple scoring system was developed for the diagnosis of HVKp infections. The system allows early identification of patients ... A retrospective cohort study of 222 patients with K. pneumoniae bloodstream infections (BSIs) was performed. Patient ... and capsular serotype K1 were identified as risk factors for HVKp infections. A scoring system was developed based on the risk ...
Risk factors for nosocomial carbapenem-resistant Klebsiella infections. Sevil Alkan Çeviker1, Özgür Günal2, Süleyman Sırrı ... Risk factors for nosocomial carbapenem-resistant Klebsiella infections. FNG & Demiroğlu Bilim Tıp Dergisi 2019;5(3):124-133. ... Conclusion: In order to prevent spread of nosocomial CRK infections, which has gradually narrowing treatment options, there is ... study aims to evaluate the clinical outcomes of patients diagnosed with nosocomial carbapenem-resistant Klebsiella infection ( ...
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a ... Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a ...
... from colonization to bloodstream infection. Results indicate that hospitalized patients become infected with their colonizing ... Home » The clinical significance of carbapenem-resistant Klebsiella pneumoniae rectal colonization in critically ill patients: ... The clinical significance of carbapenem-resistant Klebsiella pneumoniae rectal colonization in critically ill patients: ...
  • Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae , particularly carbapenem-resistant strains (CR- Kp ) causing high mortality and morbidity, are critical concerns[ 1 ]. (biorxiv.org)
  • Orally delivered recombinant bacteriocins, like klebicins, could be employed as oral antimicrobials to eradicate multidrug-resistant Klebsiella from the intestinal tract prior to/during hospitalization. (ecco-ibd.eu)
  • Multidrug resistant (MDR) Klebsiella pneumoniae is a major cause of healthcare-associated infections around the world, with attendant high rates of morbidity and mortality. (ibm.com)
  • Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. (microbiologyresearch.org)
  • Themanagement of severe neurologic infections due to multidrug-resistant (MDR) Klebsiella pneumoniae infection remains a challenge. (figshare.com)
  • Infections caused by multidrug resistant (MDR) Klebsiella pneumoniae are difficult to treat with conventional antibiotics. (researchgate.net)
  • The absence of new, effective anti-gram-negative antibiotics makes infection control the most important countermeasure against multidrug-resistant gram-negative pathogens. (asm.org)
  • Complicated infections from multidrug-resistant Gram-negative bacteria (MDR-GNB) represent a serious problem presenting many challenges. (mdpi.com)
  • In Chile, although a sustained increase in CR- Kp infections has been observed, few strains have been described at the genomic level, lacking molecular details of their resistance and virulence determinants and the mobile elements mediating their dissemination. (biorxiv.org)
  • A search of the computerized database at the National Taiwan University Hospital was made for cefotaxime-resistant and cefmetazole-susceptible isolates of Escherichia coli and Klebsiella pneumoniae (which may be extended-spectrum β-lactamase-producing strains) in pediatric wards and intensive care units between 1999 and 2001. (ntu.edu.tw)
  • Results indicate that hospitalized patients become infected with their colonizing strains, supporting the strong association between colonization and bloodstream infections. (amr-insights.eu)
  • The article acknowledges the formation of bacterial biofilms in strains of bacteria species Klebsiella oxytoca and Klebsiella pneumoniae when grown in liquid media under the influence of negative factors (chemical factor) - containing agents. (iimmun.ru)
  • NDM-producing Klebsiella pneumoniae strains represent major clinical and infection control challenges, particularly in resource-limited settings with high rates of antimicrobial resistance. (ox.ac.uk)
  • Infection control may be effective in terminating outbreaks caused by particular strains, even in areas with widespread resistance, although this study could not demonstrate evidence supporting specific interventions. (ox.ac.uk)
  • This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. (biomedcentral.com)
  • Here we describe the first detection in Italy of the mcr-10 gene, carried by strains of Klebsiella quasipneumoniae . (biomedcentral.com)
  • Twenty ESBL producing strains (15%) including Escherichia coli (n = 9), Klebsiella pneumoniae (n = 7), Klebsiella oxytoca (n = 2) and Enterobacter aerogenes (n = 2) were detected and further analyzed for their resistance transfer features, plasmid profile and nature of the resistance genes. (scielo.br)
  • Garlic and tea have antibacterial activity against Klebsiella , as well as drug resistant strains of Saphylococci, Enterococci and Psedomonas aeruginosa . (pakalertpress.com)
  • Infections caused by all three bacteria are treated with antibiotics given by vein (intravenously). (msdmanuals.com)
  • Klebsiella , Enterobacter , and Serratia bacteria reside in the intestine of many healthy people and rarely cause infection in them. (msdmanuals.com)
  • Infections with these bacteria are often acquired in hospitals and long-term care facilities. (msdmanuals.com)
  • Infection can spread up the urinary tract to the kidneys, or uncommonly the kidneys may become infected through bacteria in the. (msdmanuals.com)
  • Rarely, Klebsiella bacteria cause pneumonia in people who live outside a health care facility (in the community), usually in people with an alcohol use disorder, older people, people with diabetes, or people with a weakened immune system. (msdmanuals.com)
  • Then Klebsiella bacteria are able to multiply and produce the toxin. (msdmanuals.com)
  • Both inhalation and instillation exposure to Cu NPs significantly decreased the pulmonary clearance of K.p.-exposed mice measured 24 hr after bacterial infection following Cu NP exposure versus sham-exposed mice also challenged with K.p (1.4 × 10(5) bacteria/mouse). (cdc.gov)
  • Since 2011 a global explosion of klebsiella infections has been reported and most importantly this bacteria is resistant to a large number of broad spectrum antibiotics. (selfgrowth.com)
  • In modern, the sepsis is managed using broad spectrum antibiotics but in klebsiella sepsis the choice of antibiotic is to be done with precaution as the bacteria is resistant to multiple antibiotics.Along with antibiotics intravenous fluid is also administered to correct the perfusion abnormalities with corticosteroids injection to reduce inflammation. (selfgrowth.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefizox and other antibacterial drugs, Cefizox should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Kadouri hopes that one day medical practitioners can use these predator bacteria to supplement antibiotic drugs in treating life-threatening infections. (newswise.com)
  • Klebsiella pneumoniae bacteria are major pathogens in human and animals. (pasteur.fr)
  • These bacteria can cause mild udder infections with a mild increase in somatic cell count and slight reduction in milk production. (cornell.edu)
  • Therefore, effective strategies must be implemented to combat antibiotic-resistant bacteria, along with stricter adherence to infection control programmes. (who.int)
  • You can get E. coli infections by eating foods containing the bacteria. (medlineplus.gov)
  • Common klebsiellae infections in humans include (1) community-acquired pneumonia, (2) UTI, (3) nosocomial infection, (4) rhinoscleroma and ozena, (5) chronic genital ulcerative disease, and (6) colonization. (medscape.com)
  • The in vivo efficacy studies showed that pBut_20 alleviated K. pneumonia lung infection without inducing damage to major organs. (ibm.com)
  • The polymer with optimal composition alleviates Klebsiella pneumonia lung infection without inducing damage to major organs. (ibm.com)
  • Other conditions such as pneumonia or urinary tract infections can trigger the release of counter-regulatory hormones that may contribute to the decrease in insulin's activity and secretion. (ascls.org)
  • Klebsiella pneumoniae is a common hospital-acquired pathogen, causing classical K. pneumoniae (CKp) infections such as pneumonia, urinary tract infection, intra-abdominal infection and bacteremia in immunocompromised patients [ 1 ]. (biomedcentral.com)
  • 4 Cephalosporins as bactericidal, cell wall-active β-lactam agents were introduced in the 1980s and as a result of effectiveness against broad-spectrum β-lactamases became standard for treatment of severe conditions such as bloodstream infections, pneumonia and intra-abdominal infections, until ESBLs started compromising usefulness in response to overuse and selective pressure. (ajlmonline.org)
  • These infections can take the form of sepsis, urinary tract infection, pneumonia and wound infections. (selfgrowth.com)
  • In klebsiella sepsis, it's obvious that the reason for sepsis is the klebsiella infection in the body like klebsiella pneumonia, abdominal infections, klebsiella urinary tract infection and blood stream infection. (selfgrowth.com)
  • Klebsiella pneumonia showing consolidations and fibrosis in anteroposterior view of lungs in X-ray and sputum test in this case. (selfgrowth.com)
  • Within the frame of the DFG-funded Transregional Collaborative Research Center SFB-TR 84 "Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia" we help to elucidate mechanisms of early pathogen attack in lung infection. (fu-berlin.de)
  • The new guidelines are designed to reduce the incidence of pneumonia and other severe, acute lower respira- tory tract infections in acute-care hospitals and in other health-care settings (e.g., ambulatory and long-term care institu- tions) and other facilities where health care is provided. (cdc.gov)
  • Klebsiella pneumoniae, Klebsiella oxytoca, and Klebsiella granulomatis . (medscape.com)
  • Foram detectadas vinte cepas produtoras de ESBL, entre as quais Escherichia coli (n=9), Klebsiella pneumoniae (n=7), Klebsiella oxytoca (n=2) e Enterobacter aerogenes (n=2), que foram posteriormente analisadas quanto a suas características de transferência de resistência, perfil plasmidial e natureza dos genes de resistência. (scielo.br)
  • Many labs have adopted CLSI recommendations and only attempted to detect ESBLs in Escherichia coli , Klebsiella pneumoniae , K. oxytoca , and Proteus mirabilis ( 8 ). (asm.org)
  • Enterobacter aerogenes Hormaeche and Edwards 1960 (Approved Lists 1980) and Klebsiella mobilis Bascomb et al. (wikipedia.org)
  • Following entrance of Enterobacter or Citrobacter into the mammary gland, most infections are of short duration, although a handful may become chronic, lasting more than 100 days. (cornell.edu)
  • [ 2 ] In recent years, klebsiellae have become important pathogens in nosocomial infections. (medscape.com)
  • Infection control can prevent additional infections and the spread of resistant pathogens and thereby reduce the need to use antibiotics. (asm.org)
  • This retrospective case-control study aims to evaluate the clinical outcomes of patients diagnosed with nosocomial carbapenem-resistant Klebsiella infection (CRK), identify risk factors of this infection, and determine mortality rate. (journalmeddbu.com)
  • We sequenced carbapenem-resistant K. pneumoniae isolates from 26 individuals involved in several infection case clusters in a Nepali neonatal unit and 68 other clinical Gram-negative isolates from a similar time frame, using Illumina and PacBio technologies. (ox.ac.uk)
  • ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
  • The most prevalent HAI are the Klebsiella species. (ecco-ibd.eu)
  • One species of Klebsiella produces a toxin that can cause inflammation of the colon and bleeding (hemorrhagic colitis) after antibiotics are taken. (msdmanuals.com)
  • Initial antimicrobial choice is empiric, and in simple infections should cover Staphylococcus and Streptococcus species. (aafp.org)
  • Organisms previously known as Klebsiella ozaenae and Klebsiella rhinoscleromatis are considered nonfermenting subspecies of K pneumoniae that have characteristic clinical manifestations. (medscape.com)
  • Differentiating nosocomial colonization from infection presents a formidable challenge in clinical practice. (medscape.com)
  • Clinical Microbiology and Infection. (wikipedia.org)
  • This case provides clinical evidence that the intrathecal, intravenous and aerosol inhalation of colistin sulfate by multichannel application can be a last resort in refractory intracranial infection by MDR K. pneumoniae. (figshare.com)
  • Hypervirulent Klebsiella pneumoniae (HVKp) infections have distinct clinical manifestations from classical K. pneumoniae infections. (biomedcentral.com)
  • Even though the diagnostic criteria of HVKp infections has still not been formally established [ 7 ], definition of HVKp infections should be based on clinical manifestations rather than microbiological analyses, since molecular analyses of virulence genes do not seems to be feasible in many microbiology laboratories. (biomedcentral.com)
  • For precise surveillance of the incidence and clinical spectrum of HVKp infections, proper diagnostic criteria should be established, and if microbiology methods were to be applied, they should be as simple as possible to be used as routine practice in microbiology laboratories. (biomedcentral.com)
  • A 62-year-old diabetic man with a history of right total knee arthroplasty 11 years prior who had suffered multiple episodes of prosthetic knee infection despite numerous surgeries and prolonged courses of antibiotics, with progressive clinical worsening and development of severe allergies to antibiotics, had been offered limb amputation for persistent right prosthetic knee infection due to Klebsiella pneumoniae complex. (elsevierpure.com)
  • Because of the clinical course, on day plus 1, physicians suspected a possible dengue virus infection. (cdc.gov)
  • Simple infections are usually monomicrobial and present with localized clinical findings. (aafp.org)
  • To compare the clinical impact of a prophylactic treatment with sublingual immunostimulation in the prevention of recurrent urinary tract infections (rUTIs) with the use of antibiotics. (frontiersin.org)
  • The risk of acquiring a urinary tract infection depends on the method and duration of catheterization, the quality of catheter care, and host susceptibility. (cdc.gov)
  • Reductions in CLABSIs caused by Staphylococcus aureus were more marked than reductions in infections caused by gram-negative rods, Candida spp. (cdc.gov)
  • Most community-acquired infections are caused by methicillin-resistant Staphylococcus aureus and beta-hemolytic streptococcus. (aafp.org)
  • Enfermedad granulomatosa producida por infección de KLEBSIELLA RHINOSCLEROMATIS. (bvsalud.org)
  • A granulomatous disease caused by KLEBSIELLA RHINOSCLEROMATIS infection. (bvsalud.org)
  • Mortality in KPC-producing Klebsiella pneumoniae bloodstream infections: a changing landscape. (bvsalud.org)
  • A retrospective cohort study of 222 patients with K. pneumoniae bloodstream infections (BSIs) was performed. (biomedcentral.com)
  • Risk factors for HVKp infections in patients with K. pneumoniae bloodstream infections (BSIs) has been studied. (biomedcentral.com)
  • Carbapenems are last-resort antibiotics for treating severe infections caused by MDR Enterobacteriaceae [ 3 ]. (biorxiv.org)
  • Progressive reduction in potency of antibiotics capable of treating MDR K. pneumoniae infections - including lung infection - as a consequence of escalating drug resistance provides the motivation to develop drug candidates targeting MDR K. pneumoniae. (ibm.com)
  • infections accordingly become quickly resistant to standard antibiotics during treatment, necessitating a change in antibiotic to avoid worsening of the sepsis. (wikipedia.org)
  • We hypothesized that activation of innate effector systems could sensitize MDR Klebsiella to conventional antibiotics. (researchgate.net)
  • A distinctive form of tissue-invasive community-associated Klebsiella pneumoniae infection, typified by primary liver abscess and bacteremia, has been well known in Asia for 2 decades ( 1 - 4 ). (cdc.gov)
  • Sepsis and Septic Shock Sepsis is a serious bodywide response to bacteremia or another infection plus malfunction or failure of an essential system in the body. (msdmanuals.com)
  • BACKGROUND: Klebsiella pneumoniae causes serious, life-threatening infections in humans in endemic and epidemic settings. (duke.edu)
  • Siu LK , Yeh K-M , Lin J-C , Fung C-P , Chang F-Y . Klebsiella pneumoniae liver abscess: a new invasive syndrome. (microbiologyresearch.org)
  • The hallmark of HVKp infections are liver abscess formation and metastatic infections. (biomedcentral.com)
  • reported that patients with HVKp infection had higher proportions of diabetes mellitus, and their infections had significantly higher propensity to liver abscess formation among Japanese patients with K. pneumoniae BSIs [ 12 ]. (biomedcentral.com)
  • The urinary tract is the most common site of nosocomial infection, accounting for more than 40% of the total number reported by acute-care hospitals and affecting an estimated 600,000 patients per year (1). (cdc.gov)
  • The control group was randomly selected among patients matched for gender who were hospitalized within the same period (±15 days) and had nosocomial infection but without CRK growth in cultures. (journalmeddbu.com)
  • Klebsiella pneumoniae (Kp) reference strain Kp52.145 is widely used in experimental Klebsiella pathophysiology. (microbiologyresearch.org)
  • This study aimed to investigate the antimicrobial efficacy of orally delivered Eudragit - coated klebicin (KvarIa) in a murine lower gastrointestinal tract model of K. quasipneumoniae infection. (ecco-ibd.eu)
  • Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model. (cdc.gov)
  • METHODS: We used Klebsiella pneumoniae (K.p.) in a murine lung infection model to determine if pulmonary bacterial clearance is enhanced or impaired by Cu NP exposure. (cdc.gov)
  • If we talk about klebsiella sepsis then it is most common in immunocompromised populations like patients suffering from cancer, diabetes, children and others. (selfgrowth.com)
  • In this article our main focus will remain on klebsiella induced sepsis. (selfgrowth.com)
  • Now let's discuss klebsiella induced sepsis in detail. (selfgrowth.com)
  • Sepsis is termed as the body's extreme reaction to any infection (in this case reaction to klebsiella infection) and extreme reaction requires emergency medical attention. (selfgrowth.com)
  • Sepsis is a hard to identify condition, but is typically denoted by high respiratory rate, high high rate, low or high body temperature, low or high white blood cell count and a suspected or known infection in the body. (selfgrowth.com)
  • Laboratory testing may be required to confirm an uncertain diagnosis, evaluate for deep infections or sepsis, determine the need for inpatient care, and evaluate and treat comorbidities. (aafp.org)
  • In addition to carrying genes for virulence factors RmpA, aerobactin and salmochelin, plasmid II has acquired in SB5881, the conjugation machinery gene cluster from plasmid I. We report the first case of community-acquired infection caused by a hypervirulent ST66-K2 Kp strain in Europe. (microbiologyresearch.org)
  • The system allows early identification of patients with K. pneumoniae BSIs in whom hypervirulent infections should be evaluated. (biomedcentral.com)
  • The objective of this study was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher during warm months. (duke.edu)
  • An increased incidence of these infections in a herd warrants reassessment of the teat dip product used in the dairy and application methods. (cornell.edu)
  • To investigate the incidence, microbial aetiology, antimicrobial resistance profile, and mortality rate of healthcare- associated infections in intensive care units in the Islamic Republic of Iran. (who.int)
  • We found 4 additional patients infected with K . pneumoniae in 2009 who did not have invasive infections. (cdc.gov)
  • The presence of invasive devices in hospitalized patients greatly increases the likelihood of infection. (medscape.com)
  • Patients with these infections have similar presentations to those with infections caused by other organisms. (medscape.com)
  • Health-care--associated infections (HAIs) affect 5% of patients hospitalized in the United States each year. (cdc.gov)
  • Health-care--associated infections (HAIs) account for a substantial portion of health-care--acquired conditions ( 1 ) that harm patients receiving medical care. (cdc.gov)
  • Reported infection rates vary widely, ranging from 1%-5%, after a single brief catheterization (3) to virtually 100% for patients with indwelling urethral catheters draining into an open system for longer than 4 days (4). (cdc.gov)
  • In these studies, errors in maintaining sterile closed drainage were common and predisposed patients to infection. (cdc.gov)
  • Such infection in otherwise healthy patients is often asymptomatic and is likely to resolve spontaneously with the removal of the catheter. (cdc.gov)
  • RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
  • Due to the severe sequelae of these complications, method to identify patients at-risk of HVKp infections should be developed. (biomedcentral.com)
  • In addition, based on such criteria, methods to identify patients with K. pneumoniae BSIs who are at-risk of HVKp infections should be investigated. (biomedcentral.com)
  • Patients with complicated infections, including suspected necrotizing fasciitis and gangrene, require empiric polymicrobial antibiotic coverage, inpatient treatment, and surgical consultation for debridement. (aafp.org)
  • Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
  • Healthcare-associated infections are a major cause of mortality worldwide, especially in intensive care units where severely ill patients have limited physical space. (who.int)
  • This observational study retrospectively reviewed the medical records of 1722 intensive care units patients with confirmed healthcare-associated infections at hospitals affiliated with Mashhad University of Medical Sciences in 2017-2019. (who.int)
  • Healthcare-associated infections in nearly half of intensive care unit patients were fatal, especially when caused by Acinetobacter spp. (who.int)
  • Biofilms, as a community of microorganisms cause many chronic infections (meningitis, inflammatory diseases of the oral cavity, urogenital infections) and create problems in the industry (fouling of processing equipment, ship hulls, oil platforms, biocorrosion metal products). (iimmun.ru)
  • In this study, we report a degradable guanidinium-functionalized polycarbonate with unexpected antimicrobial activity and selectivity towards MDR Klebsiella pneumoniae. (ibm.com)
  • Our research aimed to use synthetized aroylated phenylenediamines (APDs) to induce the expression of cathelicidin antimicrobial peptide gene (CAMP) to minimize the necessity of antibiotic use during infection. (researchgate.net)
  • CDC defines a CLABSI as recovery of a pathogen from a blood culture (a single blood culture for organisms not commonly present on the skin and two or more blood cultures for organisms commonly present on the skin) in a patient who had a central line at the time of infection or within the 48-hour period before development of infection. (cdc.gov)
  • Availability of iron increases host susceptibility to K pneumoniae infection. (medscape.com)
  • Central line--associated blood-stream infections (CLABSIs) are one of the most deadly types of HAIs, with a mortality rate of 12%--25% ( 2 ). (cdc.gov)
  • CI, and to identify univariate and multivariate predictors of healthcare-associated infection mortality. (who.int)
  • Phage therapy is a promising strategy to manage such infections including those involving antibiotic-resistant microbes, and to target microbial biofilms. (elsevierpure.com)
  • Abscess in the Lungs A lung abscess is a pus-filled cavity in the lung surrounded by inflamed tissue and caused by an infection. (msdmanuals.com)
  • In this study, the structures of the polymers were optimized for the treatment of MDR Klebsiella pneumoniae lung infection. (ibm.com)
  • Taken together, pBut_20 is promising for treating MDR Klebsiella pneumoniae lung infection in vivo. (ibm.com)
  • CONCLUSIONS: Cu NP exposure impaired host defense against bacterial lung infections and induced a dose-dependent decrease in bacterial clearance in which even our lowest dose demonstrated significantly lower clearance than observed in sham-exposed mice. (cdc.gov)
  • Thus, exposure to Cu NPs may increase the risk of pulmonary infection. (cdc.gov)
  • To test the accuracy of the Ultra assay in children, researchers with the Beijing Pediatric Research Institute and Beijing Children's Hospital enrolled 93 children with pulmonary tuberculosis and 128 children with respiratory tract infections. (umn.edu)
  • Limited antibiotic treatment regimens make treatment of severe MDR K. pneumoniae infection more difficult. (figshare.com)
  • See related handout on skin and soft tissue infections , written by the authors of this article. (aafp.org)
  • Skin and soft tissue infections result from microbial invasion of the skin and its supporting structures. (aafp.org)
  • Skin and soft tissue infections (SSTIs) account for more than 14 million physician office visits each year in the United States, as well as emergency department visits and hospitalizations. (aafp.org)
  • Comorbidities, skin and soft tissue infections, and infections with Acinetobacter spp. (who.int)
  • Scholars@Duke publication: Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents. (duke.edu)
  • K granulomatis infection can result in granuloma inguinale or donovanosis, although these are uncommon in developed temperate countries. (medscape.com)
  • The genus Klebsiella belongs to the tribe Klebsiellae, a member of the family Enterobacteriaceae.The organisms are named after Edwin Klebs, a 19th century German microbiologist. (medscape.com)
  • Genome sequencing of an extended series of NDM-producing Klebsiella pneumoniae isolates from neonatal infections in a Nepali hospital characterizes the extent of community- versus hospital-associated transmission in an endemic setting. (ox.ac.uk)
  • Although not all catheter-associated urinary tract infections can be prevented, it is believed that a large number could be avoided by the proper management of the indwelling catheter. (cdc.gov)
  • Adoption of the closed method of urinary drainage has markedly reduced the risk of acquiring a catheter-associated infection, but the risk is still substantial. (cdc.gov)
  • Host factors which appear to increase the risk of acquiring catheter-associated urinary tract infections include advanced age, debilitation, and the postpartum state (7,8). (cdc.gov)
  • Catheter-associated urinary tract infections are generally assumed to be benign. (cdc.gov)
  • The natural history of catheter associated urinary tract infections has been largely unstudied. (cdc.gov)
  • This undermines the effectiveness of the available treatment options and thus contributes to the persistence of microbial infections. (who.int)
  • The intensive care units (ICUs), in particular, are hotbeds for contracting infections ( 5 ). (who.int)
  • Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. (ajlmonline.org)
  • Organisms that produce ESBLs are an important reason for therapy failure with cephalosporins and have serious consequences for infection control. (ajlmonline.org)
  • KEGG GENOME: Klebsiella pneumoniae subsp. (genome.jp)
  • Complete Genome Sequence of Klebsiella pneumoniae Strain ATCC 43816 KPPR1, a Rifampin-Resistant Mutant Commonly Used in Animal, Genetic, and Molecular Biology Studies. (genome.jp)