Laryngeal Neoplasms
Death, Sudden
Bereavement
Coroners and Medical Examiners
Cause of Death
Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas. (1/1167)
Laryngeal papillomas are benign tumors caused by human papillomaviruses types 6 and 11. This study addressed alterations in levels of signal transduction from the epidermal growth factor receptor (EGFR) in papillomas and cultured papilloma cells compared to normal tissue and cells. Mitogen-activated protein kinase (MAPK) was activated to a greater extent, phosphotyrosine was more abundant, and EGFR was overexpressed in laryngeal papillomas compared to normal laryngeal epithelium by Western blot analysis. The EGFR was 3 times more abundant in cultured papilloma cells than in normal laryngeal cells by Scatchard analysis and Western blot, without gene amplification or an increase in steady-state levels of mRNA. Following stimulation with EGF, a significant portion of the EGFR was recycled to the surface in papilloma cells, whereas in normal cells, it was not. Tyrosine kinase activity and activation of MAPK was more responsive to epidermal growth factor stimulation in papilloma cells than in uninfected primary laryngeal cells. PD153035, a specific inhibitor of the EGFR, and an EGFR-specific antibody that blocks ligand binding completely abrogated basal MAPK activation by endogenous ligands in laryngeal papilloma cells. These results demonstrated that infection of laryngeal epithelium by low-risk human papillomaviruses elevates the EGFR by posttranslational mechanisms, increasing its responsiveness to ligand-mediated activation. They also showed that MAPK activation in laryngeal papillomas depends upon ligand-mediated EGFR stimulation. (+info)Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. (2/1167)
Glutathione S-transferases (GSTs) are involved in detoxification of reactive metabolites of carcinogens and, therefore, could be potentially important in susceptibility to cancer. The associations between larynx cancer risk and GSTM3 and GSTP1 gene polymorphisms, either separately or in combination with GSTM1 and GSTT1 gene polymorphisms, were evaluated using peripheral blood DNA from 129 cancer patients and 172 controls, all regular smokers. The frequencies of GSTM3 AA, AB, and BB genotypes were 60.5%, 36.4%, and 3.1% in cases and 72.7%, 24.4%, and 2.9% in controls, respectively. The frequencies of GSTP1 AA, AG, and GG genotypes were 48.1%, 40.3%, and 11.6% in cases and 50.0%, 37.2%, and 12.8% in controls, respectively. Multivariate logistic regression analyses did not reveal any association between the GSTP1 (AG or GG) genotype and larynx cancer [odds ratio, 1.1; 95% confidence interval (CI), 0.7-2.0]. In contrast, a significant increase in risk was related to the GSTM3 (AB or BB) genotype (odds ratio, 2.0; 95% CI, 1.1-3.4). The combined GSTM3 (AB or BB) and GSTM1-null genotype conferred a 4-fold risk (95% CI, 1.6-10.1) of larynx cancer as compared with the combined GSTM3 AA and GSTM1-positive genotype. However, the effect of GSTM3 (AB or BB) genotype was similar among individuals with GSTM1-positive or GSTM1-null genotypes. (+info)Concordant induction of cyclin E and p21cip1 in differentiated keratinocytes by the human papillomavirus E7 protein inhibits cellular and viral DNA synthesis. (3/1167)
Productive infections by human papillomaviruses (HPVs) occur only in differentiated keratinocytes in squamous epithelia in which the HPV E7 protein reactivates the host DNA replication machinery to support viral DNA replication. In a fraction of the differentiated keratinocytes, E7 also posttranscriptionally induces p21Cip1, which is distributed in a mutually exclusive manner with unscheduled cellular DNA synthesis. In this study, double immunofluorescence labeling unexpectedly revealed that E7 caused a concordant accumulation of both cyclin E and p21Cip1 to high levels in patient papillomas and in organotypic cultures of primary human keratinocytes. The induction of cyclin E is mutually exclusive with unscheduled cellular DNA synthesis or abundant viral DNA. These novel virus-host interactions in differentiated keratinocytes are in contrast to previous observations made in submerged proliferating cultures, in which HPV E7 induces cyclin E and overcomes p21Cip1 inhibition of S-phase entry. We propose that an appropriately timed induction of cyclin E/cyclin-dependent kinase 2 by HPV E7 in postmitotic cells enables S-phase reentry and HPV DNA amplification, whereas prematurely induced cyclin E stabilizes p21Cip1 protein, which then inhibits cyclin E/cyclin-dependent kinase 2. Consequently, cyclin E and p21Cip1 both fail to turn over, and DNA synthesis does not occur. (+info)Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. (4/1167)
PURPOSE: To determine the utility of pretreatment computed tomography (CT) for predicting primary site control in patients with supraglottic squamous cell carcinoma (SCC) treated with definitive radiotherapy (RT). MATERIALS AND METHODS: Pretreatment CT studies in 63 patients were reviewed. Minimum length of follow-up was 2 years. Local recurrence and treatment complications resulting in permanent loss of laryngeal function were documented. Tumor volume was calculated using a computer digitizer, and pre-epiglottic space (PES) spread was estimated. The data were analyzed using a combination of Fisher's exact test, logistic regression modeling, and multivariate analyses. Five-year local control rates were calculated using the product-limit method. RESULTS: Local control rates were inversely and roughly linearly related to tumor volume, although there seemed to be a threshold volume at which primary site prognosis diminished. Local control was 89% in tumors less than 6 cm3 and 52% when volumes were > or =6 cm3 (P = .0012). The likelihood of maintaining laryngeal function also varied with tumor volume: 89% for tumors less than 6 cm3 and 40% for tumors > or =6 cm3 (P = .00004). Pre-epiglottic space involvement by tumor of > or =25% was associated with a reduced chance of saving the larynx (P = .0076). Multivariate analyses revealed that only tumor volume independently altered these end points. CONCLUSION: Pretreatment CT measurements of tumor volume permits stratification of patients with supraglottic SCC treated with RT alone (which allows preservation of laryngeal function) into groups in which local control is more likely and less likely. Pre-epiglottic space spread is not a contraindication to using RT as the primary treatment for supraglottic SCC. (+info)Sternothoracotomy for combined coronary artery bypass grafting and left upper lobectomy in a patient with low-lying tracheostoma. (5/1167)
A 64-year-old man had a low-lying tracheostoma and presented with unstable angina and a mass in the pulmonary left upper lobe. Simultaneous coronary revascularization and resection of the lung neoplasm were completed through a sternothoracotomy (clam-shell) incision. The advantages of this approach include excellent exposure to the mediastinum and the lung fields, and the option of using both internal thoracic arteries for bypass grafting. (+info)Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. (6/1167)
Previous studies in our laboratory have shown that the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), suppressed autophosphorylation of epidermal growth factor (EGF) receptor induced by EGF in human A431 epidermoid carcinoma cells. In this study, we examined the inhibitory effects of black tea polyphenols, including theaflavin (TF-1), a mixture (TF-2) of theaflavin-3-gallate (TF-2a) and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3) and the thearubigin fraction on the autophosphorylation of the EGF and PDGF receptors in A431 cells and mouse NIH3T3 fibroblast cells, respectively. First, we examined the effects of these polyphenols on the proliferation of A431 and NIH3T3 cells. Both EGCG and TF-3 strongly inhibited the proliferation of A431 and NIH3T3 cells more than the other theaflavins did. In cultured cells with pre-treatment of tea polyphenol, TF-3 was stronger than EGCG on the reduction of EGF receptor and PDGF receptor autophosphorylation induced by EGF and PDGF, respectively. Other theaflavins slightly reduced the autophosphorylation of the EGF and PDGF receptors; furthermore, TF-3 could reduce autophosphorylation of the EGF receptor (or PDGF receptor) even with co-treatment with EGF (or PDGF) and TF-3, but EGCG was inactive under these conditions. In addition, TF-3 was stronger than EGCG in blocking EGF binding to its receptor. These results suggest that not only the green tea polyphenol, EGCG, but also the black tea polyphenol, TF-3, have an antiproliferative activity on tumor cells, and the molecular mechanisms of antiproliferation may block the growth factor binding to its receptor and thus suppress mitogenic signal transduction. (+info)The difference between delayed extubation and tracheostomy in post-operative sleep apnea after glossectomy or laryngectomy. (7/1167)
BACKGROUND: Patients with cancer of the tongue or larynx require glossectomies or laryngectomies and subsequent reconstruction. These procedures remove part of the patient's upper airway. In cancer of the tongue, the removed part of the airway is substituted by a flap of their skin. Post-operatively, it is possible that the patients have problems respiring comfortably. In addition to this, long surgical procedures may simply interfere with their circadian rhythm. To elucidate the possible change in their post-operative respiration, we monitored the patient's respiratory pattern with an apnea monitor. METHODS: We attached an apnea monitor to the patients and recorded their respiratory pattern and arterial oxygen saturation. The patients were monitored for a total of five days: three days prior to the operation, one day before the operation, the day of operation, two days after, and on the fourth day after the operation. The period of monitoring was from 8:00 p.m. to 6:00 a.m. the next morning. RESULTS: Sixteen patients completed this study. The patients whose tube was extubated after glossectomy showed frequent apnea, low mean oxygen saturation and low comfort score as compared to the patients with tracheostomy after laryngectomy. Because two failed cases of free skin flap were among the former, it is possible that the frequent apnea is a factor of failed free skin graft after glossectomy and laryngectomy. CONCLUSION: Further studies are required to improve the patient's respiration during their sleep after tracheal extubation in glossectomy. (+info)Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase. (8/1167)
The pi class glutathione S-transferase (GSTP1-1), which is polymorphic in human populations, is believed to play an important role in detoxification of the ultimate carcinogen of widespread environmental pollutant benzo[a]pyrene [(+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide [(+)-anti-BPDE]]. The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine). Here, we have determined the protective effect of overexpression of allelic variants of hGSTP1-1, through stable transfection in HepG2 cells, against (+)-anti-BPDE-induced DNA modification. Clonal transfectants of HepG2 cells corresponding to the three allelic variants of hGSTP1-1 [(I104,A113), (V104,A113), and (V104,V113), denoted hGSTP1(IA), hGSTP1(VA), and hGSTP1(VV), respectively] with similar levels of hGSTP1 protein were identified and characterized for their GST activity and (+)-anti-BPDE-induced DNA modification. The glutathione S-transferase activity toward (+)-anti-BPDE was significantly higher (approximately 3.0-3.6-fold) in cells transfected with hGSTP1(VA) [HepG2(VA)] and hGSTP1(VV) [HepG2(VV)] compared with hGSTP1(IA) transfectant [HepG2(IA)]. The formation of (+)-anti-BPDE-DNA adducts was significantly reduced in HepG2(VA) and HepG2(VV) cells compared with cells transfected with insert-free vector (HepG2-vect). Maximum protection against (+)-anti-BPDE-induced DNA damage was afforded by the hGSTP1(VV) isoform. The results of this study indicate that the allelic variants of hGSTP1-1 significantly differ in their ability to provide protection against (+)-anti-BPDE-induced DNA damage. Thus, hGSTP1-1 polymorphism may be an important factor in differential susceptibility of individuals to tumorigenesis induced by benzo[a]pyrene. (+info)Laryngeal neoplasms refer to abnormal growths or tumors in the larynx, also known as the voice box. These growths can be benign (non-cancerous) or malignant (cancerous). Laryngeal neoplasms can affect any part of the larynx, including the vocal cords, epiglottis, and the area around the vocal cords called the ventricle.
Benign laryngeal neoplasms may include papillomas, hemangiomas, or polyps. Malignant laryngeal neoplasms are typically squamous cell carcinomas, which account for more than 95% of all malignant laryngeal tumors. Other types of malignant laryngeal neoplasms include adenocarcinoma, sarcoma, and lymphoma.
Risk factors for developing laryngeal neoplasms include smoking, alcohol consumption, exposure to industrial chemicals, and a history of acid reflux. Symptoms may include hoarseness, difficulty swallowing, sore throat, ear pain, or a lump in the neck. Treatment options depend on the type, size, location, and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.
Sudden death is a term used to describe a situation where a person dies abruptly and unexpectedly, often within minutes to hours of the onset of symptoms. It is typically caused by cardiac or respiratory arrest, which can be brought on by various medical conditions such as heart disease, stroke, severe infections, drug overdose, or trauma. In some cases, the exact cause of sudden death may remain unknown even after a thorough post-mortem examination.
It is important to note that sudden death should not be confused with "sudden cardiac death," which specifically refers to deaths caused by the abrupt loss of heart function (cardiac arrest). Sudden cardiac death is often related to underlying heart conditions such as coronary artery disease, cardiomyopathy, or electrical abnormalities in the heart.
An autopsy, also known as a post-mortem examination or obduction, is a medical procedure in which a qualified professional (usually a pathologist) examines a deceased person's body to determine the cause and manner of death. This process may involve various investigative techniques, such as incisions to study internal organs, tissue sampling, microscopic examination, toxicology testing, and other laboratory analyses. The primary purpose of an autopsy is to gather objective evidence about the medical conditions and factors contributing to the individual's demise, which can be essential for legal, insurance, or public health purposes. Additionally, autopsies can provide valuable insights into disease processes and aid in advancing medical knowledge.
Bereavement is the state of loss or grief experienced when a person experiences the death of a loved one, friend, or family member. It is a normal response to the death of someone close and can involve a range of emotions such as sadness, anger, guilt, and anxiety. The grieving process can be different for everyone and can take time to work through. Professional support may be sought to help cope with the loss.
A coroner and medical examiner are officials in the legal system who are responsible for investigating and determining the cause of death in certain cases. While their roles can overlap, there are some differences between them.
A coroner is a public official who is typically appointed or elected to serve in a particular jurisdiction, such as a county or district. The coroner's primary responsibility is to investigate any sudden, unexpected, or suspicious deaths that occur within their jurisdiction. This may include deaths that occur due to violence, accidents, suicide, or unknown causes.
In order to determine the cause of death, the coroner may conduct an autopsy, order toxicology tests, and review medical records and other evidence. The coroner may also hold an inquest, which is a formal hearing in which witnesses are called to testify about the circumstances surrounding the death. Based on the evidence gathered during the investigation, the coroner will make a determination as to the cause and manner of death.
A medical examiner, on the other hand, is a physician who has completed specialized training in forensic pathology. Medical examiners are typically appointed or hired by a government agency, such as a state or county, to perform autopsies and investigate deaths.
Medical examiners are responsible for determining the cause of death in cases where there is a suspicion of foul play, as well as in other circumstances where the cause of death may not be immediately apparent. They may also testify in court as expert witnesses based on their findings.
In some jurisdictions, the roles of coroner and medical examiner are combined, with the official serving as both a public administrator and a trained physician. In other cases, the two roles are separate, with the coroner responsible for administrative functions and the medical examiner responsible for determining the cause of death.
Forensic pathology is a subspecialty of pathology that focuses on determining the cause and manner of death by examining a corpse. It involves applying scientific knowledge and techniques to investigate criminal or suspicious deaths, often in conjunction with law enforcement agencies. A forensic pathologist performs autopsies (postmortem examinations) to evaluate internal and external injuries, diseases, and other conditions that may have contributed to the individual's death. They also collect evidence such as tissue samples, which can be used for toxicological, microbiological, or histological analysis. The information gathered by forensic pathologists is crucial in helping to establish the facts surrounding a person's death and assisting legal proceedings.
The "cause of death" is a medical determination of the disease, injury, or event that directly results in a person's death. This information is typically documented on a death certificate and may be used for public health surveillance, research, and legal purposes. The cause of death is usually determined by a physician based on their clinical judgment and any available medical evidence, such as laboratory test results, autopsy findings, or eyewitness accounts. In some cases, the cause of death may be uncertain or unknown, and the death may be classified as "natural," "accidental," "homicide," or "suicide" based on the available information.
"Terminology as a topic" in the context of medical education and practice refers to the study and use of specialized language and terms within the field of medicine. This includes understanding the meaning, origins, and appropriate usage of medical terminology in order to effectively communicate among healthcare professionals and with patients. It may also involve studying the evolution and cultural significance of medical terminology. The importance of "terminology as a topic" lies in promoting clear and accurate communication, which is essential for providing safe and effective patient care.
Glossary of communication disorders
List of diseases (R)
Richard Norris Wolfenden
List of diseases (L)
Neoplasm
Hoarse voice
List of MeSH codes (C04)
Laryngitis
Radiation therapy
List of cancer types
List of MeSH codes (E05)
List of MeSH codes (C08)
HPV-positive oropharyngeal cancer
MIRN21
Cerebral edema
Thyroid cancer
Low-grade myofibroblastic sarcoma
Somatic evolution in cancer
Mir-708 microRNA precursor family
International Classification of Headache Disorders
List of MeSH codes (C23)
H19 (gene)
List of skin conditions
P16
Carcinogenesis
Glossary of medicine
Esophageal cancer
Cancer epigenetics
CT Scan of the Larynx: Overview, Laryngeal Embryology and Anatomy, Laryngeal Neoplasms
Glossary of communication disorders - Wikipedia
Throat Cancer | Throat Cancer Symptoms | MedlinePlus
US assessment of HPV types in cancers: implications for current and 9-valent HPV vaccines
Five hundred cancers of the larynx and pyriform sinus. Results of treatment by radiation and surgery
Glossary of communication disorders - Wikipedia
Pathology of Sudden Natural Death: Overview, Terminology, Medical Examiner Role and Autopsy Indications
Find a Clinical Trial | Mount Sinai - New York
Page 1 | Search Results | Acta Cytologica | Karger Publishers
Primary and salvage (hypo)pharyngectomy: Analysis and outcome<...
Portal Regional da BVS
HuGE Navigator|Genopedia|PHGKB
Can pretreatment computed tomography findings predict local control in T3 squamous cell carcinoma of the glottic larynx treated...
Subjects: Otorhinolaryngologic Surgical Procedures - Digital Collections - National Library of Medicine Search Results
DeCS 2017 - December 21, 2017 version
Patterns of recurrence after open partial horizontal laryngectomy types II and III: Univariate and logistic regression analysis...
Richard V. Smith - Publications - Albert Einstein College of Medicine
Chemotherapy followed by accelerated fractionated radiation for larynx preservation in patients with advanced laryngeal cancer.
ZNAČAJ PEPSINA U NASTAJANJU DOBROĆUDNIH I ZLOĆUDNIH PROMJENA GRKLJANA | Repozitorij MEFOS
Neoplasm of the larynx (Concept Id: C0023055) - MedGen - NCBI
Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium
DeCS 2016 - June 12, 2016 version
HuGE Navigator|Genopedia|PHGKB
DeCS 2018 - July 31, 2018 version
DeCS 2017 - July 04, 2017 version
DeCS 2019 - June 12, 2019 version
Neoplasm staging. Medical search. Definitions
HuGE Navigator|Genopedia|PHGKB
Voice Outcomes Following Repeated Surgical Resection of Laryngeal Papillomata in Children - McMaster Experts
David G Lott - Research output - Mayo Clinic
Metastasis3
- carcinoma, squamous cell carcinoma , small cell laryngeal neoplasms lung neoplasms neoplasm metastasis Acta Cytologica Metastatic Laryngeal Basaloid Squamous Cell Carcinoma Simulating Primary. (karger.com)
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
- Objective: To investigate effects of ECRG4 on invasion and metastasis of human laryngeal squamous cell carcinoma Hep-2 and its molecular mechanism. (cnki.net)
Radiotherapy1
- Conclusions: In patients with advanced laryngeal cancer, TLM with or without radiotherapy is a valid treatment strategy for organ preservation. (elsevierpure.com)
Larynx5
- This article focuses on the use of CT imaging in the evaluation of the larynx, with particular focus on laryngeal neoplasia, trauma, foreign bodies, and radiation-induced changes. (medscape.com)
- Scholars@Duke publication: Chemotherapy followed by accelerated fractionated radiation for larynx preservation in patients with advanced laryngeal cancer. (duke.edu)
- PURPOSE: Larynx preservation in advanced, resectable laryngeal cancer may be achieved using induction chemotherapy (CT) followed in responding patients by definitive radiation (RT). (duke.edu)
- A benign or malignant neoplasm involving the larynx. (nih.gov)
- Non-epithelial malignant neoplasms of the larynx. (nih.gov)
Carcinoma4
- carcinoma, neuroendocrine carcinoma , small cell cervical smears cervix neoplasms 30 9 2011 Acta Cytologica Exfoliative Cytology of Invasive Neuroendocrine Small Cell. (karger.com)
- carcinoma , small cell vaginal smears cervical smears endometrial neoplasms Acta Cytologica Exfoliative Cytology. (karger.com)
- In choosing the best surgical treatment (total or partial laryngectomy) for patients affected by laryngeal squamous cell carcinoma (SCC), it is still necessary to identify a link between prognostic factors and oncological outcomes. (unito.it)
- Laryngeal carcinoma must be differentiated from laryngeal syphilis, lymphoma , and chronic laryngitis . (wikidoc.org)
Benign3
- Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
- [ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
- Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
Malignant neoplasms1
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
Parotid Neoplasms3
- The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
- Common parotid neoplasms. (medscape.com)
- Radiation therapy in low doses has been associated with the development of parotid neoplasms 15-20 years after treatment. (medscape.com)
Cancer19
- What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment? (medlineplus.gov)
- HPV DNA was detected in 90.6% of cervical, 91.1% of anal, 75.0% of vaginal, 70.1% of oropharyngeal, 68.8% of vulvar, 63.3% of penile, 32.0% of oral cavity, and 20.9% of laryngeal cancers, as well as in 98.8% of cervical cancer in situ (CCIS). (nih.gov)
- A retrospective analysis of clinical outcomes of 819 patients affected by laryngeal cancer who underwent OPHL type II and III between 1995 to 2014 was carried out. (unito.it)
- METHODS: Patients with advanced laryngeal cancer received two cycles of cisplatin 100 mg/m2 and fluorouracil (5-Fu) 1,000 mg/m2/d for 5 days. (duke.edu)
- The Animal products and cereals (OR = 1.5, 95% CI = 1.1, 2.1) and the Fats (OR = 1.8, 95% CI = 1.4, 2.3) patterns were positively associated with laryngeal cancer risk, whereas a linear inverse trend in laryngeal cancer risk was evident for the Antioxidant vitamins and fiber pattern. (unimib.it)
- Imaging modalities have become increasingly significant in the treatment of laryngeal cancer. (johnshopkins.edu)
- This article provides an up-to-date review of the radiographic evaluation of the normal neck and information for both the radiologist and clinician treating the patient with laryngeal cancer. (johnshopkins.edu)
- Technical considerations, imaging-based staging systems, and the radiographic characteristics of laryngeal cancer in various regions of the neck are discussed. (johnshopkins.edu)
- Zinreich, SJ 2002, ' Imaging in laryngeal cancer: Computed tomography, magnetic resonance imaging, positron emission tomography ', Otolaryngologic Clinics of North America , vol. 35, no. 5, pp. 971-991. (johnshopkins.edu)
- Objective: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of advanced laryngeal cancer. (elsevierpure.com)
- To the Editor: In the October 22 issue, Dr. McNeil and her colleagues presented an interesting methodologic construct for investigating the trade-off between the quality and the duration of life in patients with laryngeal cancer. (johnshopkins.edu)
- 1 Their study, however, contains a serious methodologic flaw, which limits any generalization to persons who actually have laryngeal cancer: The subjects in the experiment did not have this disease. (johnshopkins.edu)
- abstract = "To the Editor: In the October 22 issue, Dr. McNeil and her colleagues presented an interesting methodologic construct for investigating the trade-off between the quality and the duration of life in patients with laryngeal cancer.1 Their study, however, contains a serious methodologic flaw, which limits any generalization to persons who actually have laryngeal cancer: The subjects in the experiment did not have this disease. (johnshopkins.edu)
- Laryngeal cancer is the second most common type of head and neck cancer worldwide. (medscape.com)
- In 2002, approximately 160,000 cases of laryngeal cancer and 90,000 deaths were reported worldwide. (medscape.com)
- Anti-EGFR treatment effects on laryngeal cancer st. (fapesp.br)
- Laryngeal cancer (LC) is one of the common head and neck neoplasms and is characterized by resistance to conventional therapy and poor prognosis. (fapesp.br)
- Subpopulations positive for CD44, CD133, and CD117 or lacking these biomarkers were classified as laryngeal cancer stem cells (LCSCs) or laryngeal cancer non-stem cells (non-LCSCs), respectively. (fapesp.br)
- Laryngeal cancer should be differentiated from other diseases presenting as a neck mass. (wikidoc.org)
Tumors5
- Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
- Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
- Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
- This theory more logically explains neoplasms that contain multiple discrete cell types, such as pleomorphic adenomas and Warthin tumors. (medscape.com)
- Laryngeal inflammatory myofibroblastic tumor, a rare entity, should definitely be distinguished from malignant laryngeal tumors. (jceionline.org)
Lung1
- Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans. (richarddollconsortium.org)
Surgical Resection1
- In 1852, Horace Green reported the first surgical resection of a laryngeal lesion, a polyp in the ventricle, removed under direct vision. (medscape.com)
Cancers3
- Can Laryngeal and Hypopharyngeal Cancers Be Found Early? (medlineplus.gov)
- Can Laryngeal and Hypopharyngeal Cancers Be Prevented? (medlineplus.gov)
- This is the first time an association between smoking and oral and laryngeal cancers has been shown in sub-Saharan Africa. (richarddollconsortium.org)
Patients3
- The acquisition time for a CT image is extremely short (within a matter of seconds), which is quite useful for the laryngeal examination, as patients are generally required to hold their breath to reduce movement. (medscape.com)
- Contrasting information was derived through a literature review by Louredo et al, which indicated that in pediatric patients, most salivary gland neoplasms (75.4%) are malignant. (medscape.com)
- Salivary gland neoplasms occurred with slightly greater frequency in girls (57.4% of patients) than in boys. (medscape.com)
Subglottic2
- Failure of complete recanalization results in laryngeal or subglottic stenosis. (medscape.com)
- The fifth and sixth branchial arches develop into the glottic and subglottic structures, as well as those muscles that are supplied by the superior laryngeal nerve. (medscape.com)
Growths1
- Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Lymphatic1
- Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Muscles1
- The fourth branchial arch develops into the supraglottic structures and the muscles that are supplied by the superior laryngeal nerve. (medscape.com)
Primary1
- A tumor score was calculated and assigned to each primary lesion depending on the extent of laryngeal spread. (duke.edu)
Tumor2
- Inflammatory myofibroblastic tumor is a borderline neoplasm with uncertain malignant potential. (jceionline.org)
- The case was diagnosed with laryngeal inflammatory myofibroblastic tumor in the light of histopathological and immunohistochemical findings. (jceionline.org)
Etiology2
- The etiology of salivary gland neoplasms is not fully understood. (medscape.com)
- Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
Fractures1
- CT imaging is best for evaluation of occult fractures and dislocations during laryngeal trauma. (medscape.com)
Treatment2
- The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
- Treatment of paediatric laryngeal papillomas: web survey of British Association of Paediatric Otolaryngologists. (nih.gov)
Dosage1
- It is our contention that serial section studies of biopsied laryngeal specimens labelled with tritiated thymidine tend to disprove the claims made favoring the value of low dosage radiation. (mssm.edu)
Tumors9
- Adaptive image-guided IMRT appears to be a promising approach for dose escalation in pharyngo-laryngeal tumors. (nih.gov)
- Adaptive IMRT with FDG-PET images has a significant impact on the delineation of TVs and on the dose distribution in pharyngo-laryngeal tumors. (nih.gov)
- 6. [Epidemiology and clinical manifestation of laryngeal tumors treated at the Hospital Virgen de la Salud of Toledo, Spain]. (nih.gov)
- Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
- Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
- [ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
- Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
- Methods: A retrospective study, 157 formalin- fixed, paraffin-embedded (FFPE) including benign and malignant laryngeal tumors tissues blocks were collected. (pdfplayer.org)
- Also immunohistochemistry (IHC) tests were perform to investigate the proteins expression of P53 gene as well as high HPV oncogenes E6 and E7 in benign and malignant laryngeal tumors. (pdfplayer.org)
Squamous1
- INTRODUCTION: A multitude of treatment modalities have been proposed in management of early laryngeal squamous cell cancers(SCC). (bvsalud.org)
Laryngectomy4
- To investigate the feasibility of modified frontolateral partial laryngectomy without tracheotomy for patients with early-stage laryngeal cancer or dysplasia of the true vocal cord. (nih.gov)
- After frontolateral partial laryngectomy, the inner side of the sternohyoid muscle was drawn into the laryngeal lumen to suture it to the incisal margin of the uninjured side and to the false vocal cord on the side of the lesion to ensure the safety without tracheotomy. (nih.gov)
- 9. [Horizontal laryngectomy in treatment of laryngeal cancer--oncologic and function results]. (nih.gov)
- Subtotal laryngectomy with Cricohyoido(epiglotto)pexy (CHEP and CHP) is a commonly used surgical procedure in France, Italy and North America, but it is rarely carried out in Germany, where most laryngeal carcinomas staged T1-T3 are resected endoscopically or with total laryngectomy. (uni-luebeck.de)
Early-stage laryngeal cancer1
- Treatment of early-stage laryngeal cancer: A comparison of treatment options. (nih.gov)
Case of recurring1
- A case of recurring laryngeal polypi with tetany. (nih.gov)
Hypopharyngeal Cancer1
- What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment? (medlineplus.gov)
Etiology1
- Also the etiology and pathogenesis factors of laryngeal cancer could include viral diseases, types of malnutrition , and local food choices (4). (pdfplayer.org)
Incidence4
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
- Age-standardized rate (ASR World) laryngeal cancer incidence was 6.4/100,000 (13.4/100,000 for males and 0.9/100,000 for females). (kbco.hr)
- The incidence of distant metastases is influenced by location of the primary tumor, initial T and N stage of the neoplasm, and the presence or absence of regional control above the clavicle. (keyopinionleaders.com)
- Head and neck cancer (HNC) is a major cause of cancer-related mortality and morbidity, and laryngeal cancer has the highest incidence in it. (elsevierpure.com)
Salivary9
- Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
- Some common salivary gland neoplasms are listed in the table below. (medscape.com)
- Salivary gland neoplasms most commonly appear in the sixth decade of life. (medscape.com)
- Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
- Salivary gland neoplasms are rare in children. (medscape.com)
- In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
- Contrasting information was derived through a literature review by Louredo et al, which indicated that in pediatric patients, most salivary gland neoplasms (75.4%) are malignant. (medscape.com)
- Salivary gland neoplasms occurred with slightly greater frequency in girls (57.4% of patients) than in boys. (medscape.com)
- Koshkareva Y, Ferris R. Salivary gland neoplasms. (cooperhealth.org)
Benign neoplasm1
- Myxomas are a rare benign neoplasm of uncertain mesenchymal cell origin, typically involving the heart. (hofstra.edu)
Epidemiology1
- 2012) 'Epidemiology of Laryngeal Cancer in Osijek-Baranja County (Eastern Croatia)', Collegium antropologicum , 36(2), pp. 107-110. (kbco.hr)
Mortality1
- Age-standardized rate (ASR World) laryngeal cancer mortality was 4.4/100,000 (9.8/100,000 for males and 0.5/100 000 for females). (kbco.hr)
Cancers3
- Can Laryngeal and Hypopharyngeal Cancers Be Found Early? (medlineplus.gov)
- Can Laryngeal and Hypopharyngeal Cancers Be Prevented? (medlineplus.gov)
- The resultant differentially expressed miRNAs were further tested by using quantitative real time PCR (qRT-PCR) on 43 laryngeal tissue samples including cancers, noncancerous counterparts, benign diseases and precancerous dysplasias. (elsevierpure.com)
Stenosis2
- Failure of complete recanalization results in laryngeal or subglottic stenosis. (medscape.com)
- Risk Factors for Adult Laryngeal Stenosis: A Review of 74 Cases. (cooperhealth.org)
Cleft2
- Failure in the development of the TES, as seen in laryngeal and laryngoesophageal cleft, results in a communication between the 2 lumens and allows for aspiration of esophageal contents. (medscape.com)
- The service range in this field includes both simple interventions to remove tonsils and the treatment of congenital malformations (aural atresia, cleft palate), as well as congenital cysts and neoplasms. (bookinghealth.com)
Pulmonary1
- Laryngeal aspergillosis is uncommon and is usually secondary to pulmonary involvement in immunocompromised patients. (biomedcentral.com)
Surgical4
- 11. Surgical treatment of laryngeal cancer. (nih.gov)
- 18. [Surgical management of laryngeal cancer and preservation of laryngeal function]. (nih.gov)
- Efforts to preserve speech and swallowing function in the surgical treatment of hypopharyngeal (and laryngeal) cancer have resulted in a declining use of total laryngopharyngectomy and improved reconstructive efforts, including microvascular free tissue transfer. (elsevierpure.com)
- However, the molecular mechanisms involved in laryngeal cancer development remain to be known and highly sensitive biomarkers and novel promising therapy is necessary.Methodology/Principal Findings:To explore laryngeal cancer-specific miRNAs, RNA from 5 laryngeal surgical specimens including cancer and non-cancer tissues were hybridized to microarray carrying 723 human miRNAs. (elsevierpure.com)
Abstract1
- abstract = "A pseudotumour represents a lesion that masquerades as a malignant neoplasm. (ed.ac.uk)
Edema3
- Laryngeal Edema" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Laryngeal Edema" by people in this website by year, and whether "Laryngeal Edema" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Laryngeal Edema" by people in Profiles. (umassmed.edu)
Lumen2
- the lumen recanalizes later by the 10th week of gestation and, in doing so, helps form the laryngeal ventricles and true and false vocal cords. (medscape.com)
- A reverted sternohyoid fascial flap was used to cover the anterior area to form a new laryngeal lumen in the shape of a ladder. (nih.gov)
Trauma2
- CT imaging is best for evaluation of occult fractures and dislocations during laryngeal trauma. (medscape.com)
- He did not have any previous history of laryngeal trauma, allergies or mycosis. (biomedcentral.com)
Prognostic1
- G870A Polymorphic Variants of CCND1 Gene and Cyclin D1 Protein Expression as Prognostic Markers in Laryngeal Lesions. (cdc.gov)
Preservation1
- The overall laryngeal preservation rate was 95% (72 of 76). (elsevierpure.com)
Male1
- We report a case of a laryngeal myxoma presenting clinically as a left vocal cord polyp in a 77 year old male, and review the literature related to this rare entity. (hofstra.edu)
Uncommon1
- Laryngeal myxomas are uncommon, and are usually misdiagnosed as laryngeal polyp. (hofstra.edu)
Commonly1
- CT scanning has become the most commonly used technique for general laryngeal imaging. (medscape.com)