Leg Ulcer
Varicose Ulcer
Stomach Ulcer
Peptic Ulcer
Compression Bandages
Skin Ulcer
Pressure Ulcer
Venous Insufficiency
Bandages, Hydrocolloid
Peptic Ulcer Hemorrhage
Lanolin
Diabetic Foot
Occlusive Dressings
Peptic Ulcer Perforation
Hematologic Agents
Debridement
Buruli Ulcer
Skin Transplantation
Chronic Disease
Skin Care
Hydroxyethylrutoside
Restless Legs Syndrome
Anemia, Sickle Cell
Treatment Outcome
Ultrasonography, Doppler, Duplex
Benzocaine
Clinical Nursing Research
Hemosiderin
Intermittent Pneumatic Compression Devices
Sex Chromosome Disorders of Sex Development
Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent. (1/298)
Several pathophysiologic mechanisms have been proposed to explain slow-healing leg ulcers, but little is known about the growth behavior of cells in these wounds. Platelet-derived growth factor-BB applied topically to chronic wounds has shown beneficial effects, although the effects have been less pronounced than would have been expected based on studies on acute wounds. The objective of this study was to compare fibroblasts in culture obtained from chronic wounds (non-healing chronic venous leg ulcers), acute wounds and normal dermis regarding growth, mitogenic response to platelet-derived growth factor-BB and levels ofplatelet-derived growth factor alpha-receptor and beta-receptor. Fibroblasts were obtained by an explant technique and expanded in vitro using fibroblast growth medium supplemented with 10% fetal bovine serum and used for the assays at their third passage. Growth of chronic wound fibroblasts (n = 8) was significantly (p < 0.05) decreased compared with those from acute wounds (n = 10) and normal dermis (n = 5). Fibroblasts from ulcers older than 3 y grew significantly (p < 0.01) slower than those from ulcers that had been present for less than 3 y. Morphology and size of fibroblasts from the oldest chronic wounds deviated substantially from those of acute wounds and normal dermis, and resembled in vitro aged or senescent fibroblasts. Mitogenic response of chronic wound fibroblasts to human recombinant platelet-derived growth factor-BB was also reduced with ulcer age. No significant differences were found in the amount of either platelet-derived growth factor alpha-receptor or beta-receptor among the three groups. The features decreased growth related to ulcer age, altered morphology, and reduced response to platelet-derived growth factor, indicating that fibroblasts in some chronic wounds have approached or even reached the end of their lifespan (phase III). This might provide one explanation for the non-healing state and therapy resistance to topical platelet-derived growth factor-BB of some venous leg ulcers. (+info)Risk factors for erysipelas of the leg (cellulitis): case-control study. (2/298)
OBJECTIVE: To assess risk factors for erysipelas of the leg (cellulitis). DESIGN: Case-control study. SETTING: 7 hospital centres in France. SUBJECTS: 167 patients admitted to hospital for erysipelas of the leg and 294 controls. RESULTS: In multivariate analysis, a disruption of the cutaneous barrier (leg ulcer, wound, fissurated toe-web intertrigo, pressure ulcer, or leg dermatosis) (odds ratio 23.8, 95% confidence interval 10.7 to 52.5), lymphoedema (71.2, 5.6 to 908), venous insufficiency (2.9, 1.0 to 8.7), leg oedema (2.5, 1.2 to 5.1) and being overweight (2.0, 1.1 to 3.7) were independently associated with erysipelas of the leg. No association was observed with diabetes, alcohol, or smoking. Population attributable risk for toe-web intertrigo was 61%. CONCLUSION: This first case-control study highlights the major role of local risk factors (mainly lymphoedema and site of entry) in erysipelas of the leg. From a public health perspective, detecting and treating toe-web intertrigo should be evaluated in the secondary prevention of erysipelas of the leg. (+info)The biomechanics of leg ulceration. (3/298)
Research performed in the late 1960s, using 24Na, suggested that the perfusion of skin and subcutaneous tissues is critically dependent on the relationship between capillary (Pc) and tissue pressures (Pt). Perfusion changes differed significantly between controls and patients with venous disease and the differences could be interpreted as evidence that Pt remained high in venous diseased patients. From this starting point, a biomechanical theory for the aetiology of venous ulceration was developed and tested by measuring skin elasticity, limb cross-sectional area and laser Doppler flux. The results confirm that, modelled as a two-compartment system (vascular and interstitial fluid), forces can be demonstrated sufficient to cause intermittent capillary closure and subsequent reperfusion injury. These forces are maximal in the gaiter area, the site of most leg ulcers. (+info)In vivo microscopic study of microcirculatory perfusion of the skin of the foot in peripheral vascular disease. (4/298)
OBJECTIVES: the aim of this study was to determine the proportion of perfused capillaries in the skin of the foot in patients with peripheral vascular disease, and compare it with that in normal subjects. DESIGN: experimental study comparing capillary perfusion in nine patients with severe peripheral vascular disease (group 2) with seven age- and sex-matched control subjects (group 1). MATERIALS AND METHODS: using in vivo video microscopy, a method was developed to measure the ratio of perfused to total capillaries, by comparing the numbers of corresponding capillaries before and after intravenous injection of sodium fluorescein. RESULTS: the mean percentage ratio of perfused to total capillaries was 54.7% (range 41-87%, standard deviation 16.5) in group 1, and 86.0% (range 62-100%, standard deviation 13.2) in group 2 (p<0.001, t-test). CONCLUSION: a significantly higher proportion of capillaries is perfused in the skin of the foot of patients with severe peripheral vascular disease than in that of normal subjects. This is of important pathophysiological significance and may have clinical implications with regard to the role of pharmacological intervention in severe limb ischaemia. (+info)Nontraumatic lower extremity amputations in the Medicare end-stage renal disease population. (5/298)
BACKGROUND: Nontraumatic lower limb amputation is a serious complication of both diabetic neuropathy and peripheral vascular disease. Many people with end-stage renal disease (ESRD) suffer from advanced progression of these diseases. This study presents descriptive information on the rate of lower limb amputation among people with ESRD who are covered by the Medicare program. METHODS: Using hospital bill data for the years 1991 through 1994 from the Health Care Financing Administration's ESRD program management and medical information system (PMMIS), amputations were based on ICD9 coding. These hospitalizations were then linked back to the PMMIS enrollment database for calculation of rates. RESULTS: The rate of lower limb amputation increased during the four-year period from 4.8 per 100 person years in 1991 to 6.2 in 1994. Among persons whose renal failure was attributed to diabetic nephropathy, the rates in 1991 and 1994 were 11.8 and 13.8, respectively. The rate among diabetic persons with ESRD was 10 times as great as among the diabetic population at large. Two thirds died within two years following the first amputation. CONCLUSIONS: The ESRD population is at an extremely high risk of lower limb amputation. Coordinated programs to screen for high-risk feet and to provide regular foot care for those at high risk combined with guidelines for treatment and referral of ulceration are needed. (+info)Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers. (6/298)
OBJECTIVE: To determine whether pentoxifylline 400 mg (Trental 400) taken orally three times daily, in addition to ambulatory compression bandages and dressings, improves the healing rate of pure venous ulcers. DESIGN: Randomised, double blind placebo controlled trial, parallel group study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and dressings materials. SETTING: Leg ulcer clinics of a teaching and a district general hospital in southern Scotland. PARTICIPANTS: 200 patients with confirmed venous ulcers and in whom other major causal factors were excluded. INTERVENTIONS: Pentoxifylline 400 mg three times daily or placebo. MAIN OUTCOME MEASURE: Complete healing (full epithelialisation) of all ulcers on the trial leg. RESULTS: Complete healing occurred in 65 of the 101 (64%) patients receiving pentoxifylline and 52 of the 99 (53%) patients receiving placebo. CONCLUSIONS: The difference in the healing rates between patients taking pentoxifylline and those taking placebo did not reach statistical significance. (+info)Preliminary report of a toxicity study of hydroxyurea in sickle cell disease. French Study Group on Sickle Cell Disease. (7/298)
AIM: To evaluate the tolerance of hydroxyurea in children affected with sickle cell disease. DESIGN: Questionnaire study of French physicians likely to treat patients with sickle cell disease. Data were collected on 101 children with sickle cell disease, treated for a median of 22 months, 36 of whom were treated for more than three years. 13 children were younger than 5 years of age at inclusion. RESULTS: Hydroxyurea was stopped for medical reasons in 11 patients: 6 failures, 1 pregnancy, 1 cutaneous rash, 1 leg ulcer, 1 lupus. Acute lymphoblastic leukaemia occurred in a girl treated for 1.5 months with hydroxyurea, this short interval arguing against a causative association. One 17 year old boy had paraparesis after 8 years of treatment. CONCLUSIONS: No major short or medium term toxicity was related to hydroxyurea in this cohort of 101 children. However, the number of children treated for more than 3 years is too few to make firm conclusions on the long term tolerance of this drug. (+info)Mycobacterium ulcerans infection (Buruli ulcer): first reported case in a traveler. (8/298)
A chronic, painless sore developed over a 2-month period on the left calf of a Canadian man traveling for 8 months in Africa. A presumptive diagnosis of a Mycobacterium spp. infection was made despite initially negative biopsy and culture results, after failure of several courses of anti-bacterial antibiotics. Mycobacterium ulcerans was eventually isolated and the lesion progressed despite treatment with multiple anti-mycobacterial agents. The lesion finally responded to wide and repeated excision, aggressive treatment with anti-mycobacterial antibiotics, and split-thickness skin grafting. The isolation and treatment of this unusual organism are discussed. (+info)A leg ulcer is a chronic wound that occurs on the lower extremities, typically on the inner or outer ankle. It's often caused by poor circulation, venous insufficiency, or diabetes. Leg ulcers can also result from injury, infection, or inflammatory diseases such as rheumatoid arthritis or lupus. These ulcers can be painful, and they may take a long time to heal, making them prone to infection. Proper diagnosis, treatment, and wound care are essential for healing leg ulcers and preventing complications.
A varicose ulcer is a type of chronic wound that typically occurs on the lower leg, often as a result of poor circulation and venous insufficiency. These ulcers form when there is increased pressure in the veins, leading to damage and leakage of fluids into the surrounding tissues. Over time, this can cause the skin to break down and form an open sore or ulcer.
Varicose ulcers are often associated with varicose veins, which are swollen and twisted veins that are visible just beneath the surface of the skin. These veins have weakened walls and valves, which can lead to the pooling of blood and fluid in the lower legs. This increased pressure can cause damage to the surrounding tissues, leading to the formation of an ulcer.
Varicose ulcers are typically slow to heal and may require extensive treatment, including compression therapy, wound care, and sometimes surgery. Risk factors for developing varicose ulcers include obesity, smoking, sedentary lifestyle, and a history of deep vein thrombosis or other circulatory problems.
In medical terms, the leg refers to the lower portion of the human body that extends from the knee down to the foot. It includes the thigh (femur), lower leg (tibia and fibula), foot, and ankle. The leg is primarily responsible for supporting the body's weight and enabling movements such as standing, walking, running, and jumping.
The leg contains several important structures, including bones, muscles, tendons, ligaments, blood vessels, nerves, and joints. These structures work together to provide stability, support, and mobility to the lower extremity. Common medical conditions that can affect the leg include fractures, sprains, strains, infections, peripheral artery disease, and neurological disorders.
A bandage is a medical dressing or covering applied to a wound, injury, or sore with the intention of promoting healing or preventing infection. Bandages can be made of a variety of materials such as gauze, cotton, elastic, or adhesive tape and come in different sizes and shapes to accommodate various body parts. They can also have additional features like fasteners, non-slip surfaces, or transparent windows for monitoring the condition of the wound.
Bandages serve several purposes, including:
1. Absorbing drainage or exudate from the wound
2. Protecting the wound from external contaminants and bacteria
3. Securing other medical devices such as catheters or splints in place
4. Reducing swelling or promoting immobilization of the affected area
5. Providing compression to control bleeding or prevent fluid accumulation
6. Relieving pain by reducing pressure on sensitive nerves or structures.
Proper application and care of bandages are essential for effective wound healing and prevention of complications such as infection or delayed recovery.
A stomach ulcer, also known as a gastric ulcer, is a sore that forms in the lining of the stomach. It's caused by a breakdown in the mucous layer that protects the stomach from digestive juices, allowing acid to come into contact with the stomach lining and cause an ulcer. The most common causes are bacterial infection (usually by Helicobacter pylori) and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). Stomach ulcers may cause symptoms such as abdominal pain, bloating, heartburn, and nausea. If left untreated, they can lead to more serious complications like internal bleeding, perforation, or obstruction.
A duodenal ulcer is a type of peptic ulcer that develops in the lining of the first part of the small intestine, called the duodenum. It is characterized by a break in the mucosal layer of the duodinal wall, leading to tissue damage and inflammation. Duodenal ulcers are often caused by an imbalance between digestive acid and mucus production, which can be exacerbated by factors such as bacterial infection (commonly with Helicobacter pylori), nonsteroidal anti-inflammatory drug use, smoking, and stress. Symptoms may include gnawing or burning abdominal pain, often occurring a few hours after meals or during the night, bloating, nausea, vomiting, loss of appetite, and weight loss. Complications can be severe, including bleeding, perforation, and obstruction of the duodenum. Diagnosis typically involves endoscopy, and treatment may include antibiotics (if H. pylori infection is present), acid-suppressing medications, lifestyle modifications, and potentially surgery in severe cases.
A peptic ulcer is a sore or erosion in the lining of your stomach and the first part of your small intestine (duodenum). The most common causes of peptic ulcers are bacterial infection and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen.
The symptoms of a peptic ulcer include abdominal pain, often in the upper middle part of your abdomen, which can be dull, sharp, or burning and may come and go for several days or weeks. Other symptoms can include bloating, burping, heartburn, nausea, vomiting, loss of appetite, and weight loss. Severe ulcers can cause bleeding in the digestive tract, which can lead to anemia, black stools, or vomit that looks like coffee grounds.
If left untreated, peptic ulcers can result in serious complications such as perforation (a hole through the wall of the stomach or duodenum), obstruction (blockage of the digestive tract), and bleeding. Treatment for peptic ulcers typically involves medications to reduce acid production, neutralize stomach acid, and kill the bacteria causing the infection. In severe cases, surgery may be required.
Compression bandages are medical devices used to apply pressure on a part of the body, typically on limbs such as arms or legs. They are often used in the treatment of venous disorders, lymphatic disorders, and wounds, including venous ulcers, leg edema, and chronic swelling. The compression helps to promote better blood flow, reduce swelling, and aid in the healing process by helping to prevent fluid buildup in the tissues. They are usually made from elastic materials that allow for adjustable levels of compression and can be wrapped around the affected area in a specific manner to ensure proper fit and effectiveness. It is important to receive proper instruction on the application and removal of compression bandages to ensure they are used safely and effectively.
A skin ulcer is a defined as a loss of continuity or disruption of the skin surface, often accompanied by inflammation and/or infection. These lesions can result from various causes including pressure, venous or arterial insufficiency, diabetes, and chronic dermatological conditions. Skin ulcers are typically characterized by their appearance, depth, location, and underlying cause. Common types of skin ulcers include pressure ulcers (also known as bedsores), venous leg ulcers, arterial ulcers, and diabetic foot ulcers. Proper evaluation, wound care, management of underlying conditions, and prevention strategies are crucial in the treatment of skin ulcers to promote healing and prevent complications.
A pressure ulcer, also known as a pressure injury or bedsore, is defined by the National Pressure Injury Advisory Panel (NPIAP) as "localized damage to the skin and/or underlying soft tissue usually over a bony prominence or related to a medical or other device." The damage can be caused by intense and/or prolonged pressure or shear forces, or a combination of both. Pressure ulcers are staged based on their severity, ranging from an initial reddening of the skin (Stage 1) to full-thickness tissue loss that extends down to muscle and bone (Stage 4). Unstageable pressure ulcers are those in which the base of the wound is covered by yellow, tan, green or brown tissue and the extent of tissue damage is not visible. Suspected deep tissue injury (Suspected DTI) describes intact skin or non-blanchable redness of a localized area usually over a bony prominence due to pressure and/or shear. The area may be preceded by tissue that is painful, firm, mushy, boggy, warmer or cooler as compared to adjacent tissue.
Venous insufficiency is a medical condition that occurs when the veins, particularly in the legs, have difficulty returning blood back to the heart due to impaired valve function or obstruction in the vein. This results in blood pooling in the veins, leading to symptoms such as varicose veins, swelling, skin changes, and ulcers. Prolonged venous insufficiency can cause chronic pain and affect the quality of life if left untreated.
Wound healing is a complex and dynamic process that occurs after tissue injury, aiming to restore the integrity and functionality of the damaged tissue. It involves a series of overlapping phases: hemostasis, inflammation, proliferation, and remodeling.
1. Hemostasis: This initial phase begins immediately after injury and involves the activation of the coagulation cascade to form a clot, which stabilizes the wound and prevents excessive blood loss.
2. Inflammation: Activated inflammatory cells, such as neutrophils and monocytes/macrophages, infiltrate the wound site to eliminate pathogens, remove debris, and release growth factors that promote healing. This phase typically lasts for 2-5 days post-injury.
3. Proliferation: In this phase, various cell types, including fibroblasts, endothelial cells, and keratinocytes, proliferate and migrate to the wound site to synthesize extracellular matrix (ECM) components, form new blood vessels (angiogenesis), and re-epithelialize the wounded area. This phase can last up to several weeks depending on the size and severity of the wound.
4. Remodeling: The final phase of wound healing involves the maturation and realignment of collagen fibers, leading to the restoration of tensile strength in the healed tissue. This process can continue for months to years after injury, although the tissue may never fully regain its original structure and function.
It is important to note that wound healing can be compromised by several factors, including age, nutrition, comorbidities (e.g., diabetes, vascular disease), and infection, which can result in delayed healing or non-healing chronic wounds.
Hydrocolloid bandages are a type of dressing used in wound care. They consist of an outer waterproof layer and an inner hydrophilic layer made of materials such as gelatin, pectin, or carboxymethylcellulose. When the bandage comes into contact with moisture from the wound, it forms a gel that helps to maintain a moist environment, which can promote healing.
Hydrocolloid bandages are useful for managing a variety of wound types, including partial-thickness burns, pressure ulcers, and diabetic foot ulcers. They can help to protect the wound from external contaminants, reduce pain and discomfort, and provide sustained release of medications such as analgesics or antibiotics.
One advantage of hydrocolloid bandages is that they can be left in place for several days at a time, which can reduce the frequency of dressing changes and minimize trauma to the wound bed. However, it's important to monitor the wound regularly to ensure that it is healing properly and to check for signs of infection or other complications.
Peptic ulcer hemorrhage is a medical condition characterized by bleeding in the gastrointestinal tract due to a peptic ulcer. Peptic ulcers are open sores that develop on the lining of the stomach, lower esophagus, or small intestine. They are usually caused by infection with the bacterium Helicobacter pylori or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).
When a peptic ulcer bleeds, it can cause symptoms such as vomiting blood or passing black, tarry stools. In severe cases, the bleeding can lead to shock, which is a life-threatening condition characterized by a rapid heartbeat, low blood pressure, and confusion. Peptic ulcer hemorrhage is a serious medical emergency that requires immediate treatment. Treatment may include medications to reduce stomach acid, antibiotics to eliminate H. pylori infection, and endoscopic procedures to stop the bleeding. In some cases, surgery may be necessary to repair the ulcer or remove damaged tissue.
Lanolin is not strictly a medical term, but it is often used in medical contexts. Medically, lanolin is referred to as "wool fat" or "wool wax." It's a yellow, waxy substance that is secreted by the sebaceous glands of wool-bearing animals, most notably sheep. Lanolin is composed primarily of esters, alcohols, and fatty acids, and it has excellent emollient properties, making it a valuable ingredient in various medical and cosmetic products.
In medical contexts, lanolin is often used as an emollient or moisturizer in topical preparations, such as creams, ointments, and lotions. It helps to soften and soothe dry, chapped, or irritated skin by creating a protective barrier that locks in moisture. Lanolin is also used in the pharmaceutical industry as an excipient (an inactive substance that serves as a vehicle or medium for a drug) in various formulations, including tablets and capsules.
It's worth noting that some people may have allergic reactions to lanolin, so it's essential to perform a patch test before using products containing this ingredient, especially if you have sensitive skin or a history of allergies.
The term "diabetic foot" refers to a condition that affects the feet of people with diabetes, particularly when the disease is not well-controlled. It is characterized by a combination of nerve damage (neuropathy) and poor circulation (peripheral artery disease) in the feet and lower legs.
Neuropathy can cause numbness, tingling, or pain in the feet, making it difficult for people with diabetes to feel injuries, cuts, blisters, or other foot problems. Poor circulation makes it harder for wounds to heal and increases the risk of infection.
Diabetic foot ulcers are a common complication of diabetic neuropathy and can lead to serious infections, hospitalization, and even amputation if not treated promptly and effectively. Preventive care, including regular foot exams, proper footwear, and good blood glucose control, is essential for people with diabetes to prevent or manage diabetic foot problems.
I'm sorry for any confusion, but "Financial Audit" is not a medical term. It belongs to the field of accounting and finance. A financial audit is an independent examination of an organization's financial records, statements, and accounting practices to ensure that they are accurate, complete, and in accordance with applicable laws and regulations. This process is conducted by professional auditors who are unbiased and independent from the organization being audited.
Occlusive dressings are specialized bandages or coverings that form a barrier over the skin, preventing air and moisture from passing through. They are designed to create a moist environment that promotes healing by increasing local blood flow, reducing wound desiccation, and encouraging the growth of new tissue. Occlusive dressings can also help to minimize pain, scarring, and the risk of infection in wounds. These dressings are often used for dry, necrotic, or hard-to-heal wounds, such as pressure ulcers, diabetic foot ulcers, and burns. It is important to monitor the wound closely while using occlusive dressings, as they can sometimes lead to skin irritation or maceration if left in place for too long.
Peptic ulcer perforation is a serious and sightful gastrointestinal complication characterized by the penetration or erosion of an acid-peptic ulcer through the full thickness of the stomach or duodenal wall, resulting in spillage of gastric or duodenal contents into the peritoneal cavity. This leads to chemical irritation and/or bacterial infection of the abdominal cavity, causing symptoms such as sudden severe abdominal pain, tenderness, rigidity, and potentially life-threatening sepsis if not promptly diagnosed and treated with surgical intervention, antibiotics, and supportive care.
Hematologic agents are a class of drugs that affect the formation, function, or destruction of blood cells and related proteins. They include:
1. Hematopoietic growth factors: These are substances that stimulate the production of blood cells in the bone marrow. Examples include erythropoiesis-stimulating agents (ESAs) like epoetin alfa and darbepoetin alfa, which stimulate red blood cell production, and granulocyte colony-stimulating factors (G-CSFs) like filgrastim and pegfilgrastim, which stimulate white blood cell production.
2. Anticoagulants: These are drugs that prevent blood clots from forming or growing larger. Examples include heparin, warfarin, direct oral anticoagulants (DOACs) like apixaban and rivaroxaban, and antiplatelet agents like aspirin and clopidogrel.
3. Hemostatic agents: These are drugs that promote blood clotting to stop bleeding. Examples include fibrin glue, thrombin, and factor VIIa.
4. Hematological malignancy therapies: These are drugs used to treat cancers of the blood and bone marrow, such as leukemia, lymphoma, and multiple myeloma. They include chemotherapeutic agents, targeted therapies like monoclonal antibodies, immunomodulatory drugs, and proteasome inhibitors.
5. Iron chelators: These are drugs used to remove excess iron from the body in patients with conditions that cause iron overload, such as thalassemia and sickle cell disease. Examples include deferoxamine, deferasirox, and deferiprone.
6. Hemophilia therapies: These are drugs used to treat hemophilia, a genetic disorder that affects blood clotting. They include factor VIII replacement therapy for hemophilia A and factor IX replacement therapy for hemophilia B.
Debridement is a medical procedure that involves the removal of dead, damaged, or infected tissue to improve the healing process or prevent further infection. This can be done through various methods such as surgical debridement (removal of tissue using scalpel or scissors), mechanical debridement (use of wound irrigation or high-pressure water jet), autolytic debridement (using the body's own enzymes to break down and reabsorb dead tissue), and enzymatic debridement (application of topical enzymes to dissolve necrotic tissue). The goal of debridement is to promote healthy tissue growth, reduce the risk of infection, and improve overall wound healing.
Buruli ulcer is a neglected tropical disease caused by the bacterium Mycobacterium ulcerans. It mainly affects the skin and occasionally the bones and joints. The infection typically begins with a painless nodule or papule that may progress to a large, painful ulcer with undermined edges if left untreated. In severe cases, it can lead to permanent disfigurement and disability. Buruli ulcer is primarily found in rural areas of West and Central Africa, but also occurs in other parts of the world including Australia, Asia, and South America. It is transmitted through contact with contaminated water or soil, although the exact mode of transmission is not fully understood. Early diagnosis and treatment with antibiotics can cure the disease and prevent complications.
Skin transplantation, also known as skin grafting, is a surgical procedure that involves the removal of healthy skin from one part of the body (donor site) and its transfer to another site (recipient site) that has been damaged or lost due to various reasons such as burns, injuries, infections, or diseases. The transplanted skin can help in healing wounds, restoring functionality, and improving the cosmetic appearance of the affected area. There are different types of skin grafts, including split-thickness grafts, full-thickness grafts, and composite grafts, which vary in the depth and size of the skin removed and transplanted. The success of skin transplantation depends on various factors, including the size and location of the wound, the patient's overall health, and the availability of suitable donor sites.
A chronic disease is a long-term medical condition that often progresses slowly over a period of years and requires ongoing management and care. These diseases are typically not fully curable, but symptoms can be managed to improve quality of life. Common chronic diseases include heart disease, stroke, cancer, diabetes, arthritis, and COPD (chronic obstructive pulmonary disease). They are often associated with advanced age, although they can also affect children and younger adults. Chronic diseases can have significant impacts on individuals' physical, emotional, and social well-being, as well as on healthcare systems and society at large.
Skin care, in a medical context, refers to the practice of maintaining healthy skin through various hygienic, cosmetic, and therapeutic measures. This can include:
1. Cleansing: Using appropriate cleansers to remove dirt, sweat, and other impurities without stripping the skin of its natural oils.
2. Moisturizing: Applying creams or lotions to keep the skin hydrated and prevent dryness.
3. Sun Protection: Using sunscreens, hats, and protective clothing to shield the skin from harmful ultraviolet (UV) rays which can cause sunburn, premature aging, and skin cancer.
4. Skin Care Products: Using over-the-counter or prescription products to manage specific skin conditions like acne, eczema, psoriasis, or rosacea.
5. Regular Check-ups: Regularly examining the skin for any changes, growths, or abnormalities that may indicate a skin condition or disease.
6. Lifestyle Factors: Maintaining a healthy lifestyle, including a balanced diet, regular exercise, adequate sleep, and avoiding habits like smoking and excessive alcohol consumption, which can negatively impact skin health.
It's important to note that while some general skincare advice applies to most people, individual skincare needs can vary greatly depending on factors like age, skin type (oily, dry, combination, sensitive), and specific skin conditions or concerns. Therefore, it's often beneficial to seek personalized advice from a dermatologist or other healthcare provider.
Hydroxyethylrutoside is not a medical term itself, but it is a semi-synthetic flavonoid that has been used in medicine, particularly in the treatment of chronic venous insufficiency and its symptoms such as varicose veins, leg edema, and skin changes. It is believed to have anti-inflammatory, antioxidant, and vaso protective properties.
In a medical context, hydroxyethylrutoside may be referred to as a medication or pharmaceutical agent, rather than a specific disease or condition.
Restless Legs Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move one's body to stop uncomfortable or odd sensations. It most commonly affects the legs. The condition worsens during periods of rest, particularly when lying or sitting.
The symptoms typically include:
1. An uncontrollable need or urge to move the legs to relieve uncomfortable sensations such as crawling, creeping, tingling, pulling, or painful feelings.
2. Symptoms begin or intensify during rest or inactivity.
3. Symptoms are partially or totally relieved by movement, such as walking or stretching, at least as long as the activity continues.
4. Symptoms are worse in the evening or night, often leading to disturbed sleep.
The exact cause of RLS is unknown, but it may be related to abnormalities in the brain's dopamine pathways that control muscle movements. It can also be associated with certain medical conditions like iron deficiency, kidney disease, diabetes, and pregnancy. Treatment often involves addressing any underlying conditions and using medications to manage symptoms.
Sickle cell anemia is a genetic disorder that affects the hemoglobin in red blood cells. Hemoglobin is responsible for carrying oxygen throughout the body. In sickle cell anemia, the hemoglobin is abnormal and causes the red blood cells to take on a sickle shape, rather than the normal disc shape. These sickled cells are stiff and sticky, and they can block blood vessels, causing tissue damage and pain. They also die more quickly than normal red blood cells, leading to anemia.
People with sickle cell anemia often experience fatigue, chronic pain, and jaundice. They may also have a higher risk of infections and complications such as stroke, acute chest syndrome, and priapism. The disease is inherited from both parents, who must both be carriers of the sickle cell gene. It primarily affects people of African descent, but it can also affect people from other ethnic backgrounds.
There is no cure for sickle cell anemia, but treatments such as blood transfusions, medications to manage pain and prevent complications, and bone marrow transplantation can help improve quality of life for affected individuals. Regular medical care and monitoring are essential for managing the disease effectively.
"Biological dressings" refer to materials used in wound healing that are derived from biological sources, such as living cells, tissues, or extracellular matrix components. These dressings can be used to promote the regeneration and repair of damaged or injured tissues by providing a supportive environment for cell growth, differentiation, and tissue formation.
Biological dressings may be derived from various sources, including:
1. Autografts: Tissue harvested from the same individual who will receive the graft.
2. Allografts: Tissue harvested from a donor of the same species.
3. Xenografts: Tissue harvested from a donor of a different species.
4. Decellularized tissue matrices: Tissues that have had their cellular components removed, leaving behind an intact extracellular matrix scaffold.
5. Engineered tissues: Tissues created in the lab through the cultivation and assembly of cells on biocompatible scaffolds or hydrogels.
Examples of biological dressings include skin substitutes, amniotic membranes, and platelet-rich plasma (PRP) preparations. These dressings can help to reduce inflammation, prevent infection, and enhance the healing process in various types of wounds, including chronic wounds, burns, and surgical incisions.
It is important to note that while biological dressings offer several advantages over traditional wound dressings, they may also carry risks such as immune rejection or disease transmission, depending on their source and preparation. Therefore, careful consideration should be given to the selection of appropriate biological dressing materials for each individual patient and application.
Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.
Ultrasonography, Doppler, and Duplex are diagnostic medical techniques that use sound waves to create images of internal body structures and assess their function. Here are the definitions for each:
1. Ultrasonography: Also known as ultrasound, this is a non-invasive imaging technique that uses high-frequency sound waves to produce images of internal organs and tissues. A small handheld device called a transducer is placed on the skin surface, which emits and receives sound waves. The returning echoes are then processed to create real-time visual images of the internal structures.
2. Doppler: This is a type of ultrasound that measures the velocity and direction of blood flow in the body by analyzing the frequency shift of the reflected sound waves. It can be used to assess blood flow in various parts of the body, such as the heart, arteries, and veins.
3. Duplex: Duplex ultrasonography is a combination of both gray-scale ultrasound and Doppler ultrasound. It provides detailed images of internal structures, as well as information about blood flow velocity and direction. This technique is often used to evaluate conditions such as deep vein thrombosis, carotid artery stenosis, and peripheral arterial disease.
In summary, ultrasonography is a diagnostic imaging technique that uses sound waves to create images of internal structures, Doppler is a type of ultrasound that measures blood flow velocity and direction, and duplex is a combination of both techniques that provides detailed images and information about blood flow.
Benzocaine is a local anesthetic agent that works by numbing the skin or mucous membranes to block pain signals from reaching the brain. It is commonly used as a topical medication in the form of creams, gels, sprays, lozenges, and ointments to relieve pain associated with minor cuts, burns, sunburn, sore throat, mouth ulcers, and other conditions that cause discomfort or irritation.
Benzocaine works by temporarily reducing the sensitivity of nerve endings in the affected area, which helps to alleviate pain and provide a soothing effect. It is generally considered safe when used as directed, but it can have some side effects such as skin irritation, stinging, burning, or allergic reactions.
It's important to note that benzocaine products should not be used on deep wounds, puncture injuries, or serious burns, and they should not be applied to large areas of the body or used for prolonged periods without medical supervision. Overuse or misuse of benzocaine can lead to rare but serious side effects such as methemoglobinemia, a condition that affects the oxygen-carrying capacity of the blood.
Lactate dehydrogenases (LDH) are a group of intracellular enzymes found in nearly all human cells, particularly in the heart, liver, kidneys, muscles, and brain. They play a crucial role in energy production during anaerobic metabolism, converting pyruvate to lactate while regenerating NAD+ from NADH. LDH exists as multiple isoenzymes (LDH-1 to LDH-5) in the body, each with distinct distributions and functions.
An elevated level of LDH in the blood may indicate tissue damage or injury, as these enzymes are released into the circulation following cellular destruction. Therefore, measuring LDH levels is a common diagnostic tool to assess various medical conditions, such as myocardial infarction (heart attack), liver disease, muscle damage, and some types of cancer. However, an isolated increase in LDH may not be specific enough for a definitive diagnosis, and additional tests are usually required for confirmation.
Clinical nursing research is a branch of scientific inquiry that focuses on the design, implementation, and evaluation of studies aimed at improving patient care and outcomes through the development of evidence-based practices within the nursing profession. This type of research is conducted in clinical settings such as hospitals, clinics, and long-term care facilities, and often involves collaboration between nurses, other healthcare professionals, and researchers from various disciplines.
The goals of clinical nursing research include:
1. Identifying patient care needs and priorities
2. Developing and testing innovative interventions to improve patient outcomes
3. Evaluating the effectiveness of current practices and treatments
4. Disseminating research findings to inform evidence-based practice
5. Advancing nursing knowledge and theory
Clinical nursing research can encompass a wide range of topics, including symptom management, patient safety, quality improvement, health promotion, and end-of-life care. The ultimate aim of this research is to improve the quality of care delivered to patients and their families, as well as to enhance the professional practice of nursing.
Hemosiderin is a golden-brown pigment that consists of iron-containing protein complexes called ferritin and ferrikinase. It is insoluble in water and forms as a result of the breakdown of hemoglobin in the reticuloendothelial system, primarily in macrophages. Hemosiderin deposits can be found in various tissues and organs, such as the spleen, liver, and brain, under conditions of increased red blood cell destruction or impaired iron metabolism. These deposits are often associated with diseases such as hemochromatosis, thalassemia, and chronic inflammation.
Intermittent Pneumatic Compression (IPC) devices are medical devices that use inflatable garments to apply controlled pressure in a rhythmic, intermittent manner to the extremities of the body, most commonly used on the legs. These devices are designed to help improve venous and lymphatic flow, reduce edema (swelling), and prevent the formation of blood clots (deep vein thrombosis) in patients who are at risk.
The IPC device typically consists of a pump, hoses, and an air-filled garment that covers the affected limb. The pump regulates the pressure and inflation pattern, while the garment applies pressure to the limb. The compression cycle usually starts with low pressure and gradually increases to a peak pressure before decreasing again. This process is repeated at regular intervals, providing intermittent compression that mimics natural muscle contractions and helps promote blood flow.
IPC devices are often used in clinical settings such as hospitals and rehabilitation centers, but they can also be prescribed for home use. They are commonly recommended for patients who have undergone surgery, experienced trauma, or have conditions that increase their risk of developing blood clots, such as prolonged immobilization, varicose veins, or certain medical disorders.
It is essential to follow the healthcare provider's instructions when using IPC devices and report any discomfort, pain, or unusual symptoms during treatment.
Disorders/Differences of Sex Development (DSDs) related to sex chromosomes are conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. These disorders are caused by differences in the number or structure of the sex chromosomes (X and Y). Some examples of DSDs related to sex chromosomes include:
1. Turner Syndrome (45,X): This condition occurs when an individual has only one X chromosome instead of the typical pair. Affected individuals typically have female physical characteristics but may have short stature, webbed neck, and other features. They usually have underdeveloped ovaries and are unable to menstruate or bear children without medical intervention.
2. Klinefelter Syndrome (47,XXY): This condition occurs when an individual has an extra X chromosome, resulting in a total of 3 sex chromosomes (XXY). Affected individuals typically have male physical characteristics but may have reduced fertility, breast development, and other features.
3. Triple X Syndrome (47,XXX): This condition occurs when an individual has an extra X chromosome, resulting in a total of 3 sex chromosomes (XXX). Affected individuals typically have normal female physical characteristics but may have learning disabilities and other developmental delays.
4. Jacobs Syndrome (47,XYY): This condition occurs when an individual has an extra Y chromosome, resulting in a total of 3 sex chromosomes (XYY). Affected individuals typically have normal male physical characteristics but may have learning disabilities and other developmental delays.
5. Other variations such as 45,X/46,XY mosaicism or 46,XX/46,XY true hermaphroditism can also occur, leading to a range of physical and developmental characteristics that may not fit typical definitions of male or female.
It's important to note that individuals with DSDs should receive comprehensive medical care from a team of specialists who can provide individualized treatment plans based on their specific needs and circumstances.
A wound infection is defined as the invasion and multiplication of microorganisms in a part of the body tissue, which has been damaged by a cut, blow, or other trauma, leading to inflammation, purulent discharge, and sometimes systemic toxicity. The symptoms may include redness, swelling, pain, warmth, and fever. Treatment typically involves the use of antibiotics and proper wound care. It's important to note that not all wounds will become infected, but those that are contaminated with bacteria, dirt, or other foreign substances, or those in which the skin's natural barrier has been significantly compromised, are at a higher risk for infection.
Compression stockings are a specialized type of hosiery that applies pressure to your legs, promoting better blood flow. They are tightest at the ankle and gradually become less constrictive up the leg. This gradient compression helps to counteract the force of gravity and promote venous return, reducing the pooling of blood in the lower extremities.
Compression stockings are often used to help prevent or treat various conditions related to poor circulation, including:
1. Varicose veins: Enlarged, swollen, and twisting veins that are easily visible just under the surface of the skin.
2. Deep vein thrombosis (DVT): A blood clot that forms in the deep veins, usually in the legs. Compression stockings can help reduce the risk of DVT after certain surgeries or during long periods of immobilization.
3. Edema: Swelling in the legs and ankles due to fluid buildup.
4. Chronic venous insufficiency: A condition where the veins have difficulty returning blood from the legs back to the heart, leading to symptoms like leg pain, swelling, and skin changes.
5. Post-thrombotic syndrome (PTS): A long-term complication of DVT characterized by chronic leg pain, swelling, and skin ulcers. Compression stockings can help manage symptoms and prevent further complications.
There are different levels of compression available, ranging from mild (15-20 mmHg) to extra firm (50-60 mmHg). Your healthcare provider will recommend the appropriate level based on your specific condition and needs. It is essential to wear compression stockings correctly for them to be effective and avoid skin irritation or other complications.
Ulcer (dermatology)
Martorell's ulcer
Arterial insufficiency ulcer
Chronic venous insufficiency
Tropical ulcer
Bordetella trematum
Maggot therapy
Chronic wound pain
Chronic wound
Nicky Cullum
Diabetic foot ulcer
Peter DeMarco
Skin grafting
Pentoxifylline
Dermatitis
Hydrocolloid dressing
Nonthrombocytopenic purpura
Aspirin
Wound healing
The Motel Life
Honey
University of Glasgow Nursing & Health Care School
Otto III, Count of Rietberg
Albert Coates (surgeon)
Suction blister
Electrotherapy
Radionics
Ultrasonography of chronic venous insufficiency of the legs
Brugia malayi
Hydrogel dressing
Venous & Arterial Leg Ulcers | UPMC Wound Healing Services
Postthrombotic Leg Ulcer - DermIS
Laughter really is the best medicine (for leg ulcers) - ScienceBlog.com
Introduction of a new leg ulcer pathway and Urgostart dressings for venous leg ulcers in Manchester | NICE
Wound Moulage Venous Leg Ulcer, Small, Epithelisation Phase
Compression Garments for People With Venous Leg Ulcers | CADTH
Speak to Analyst - Venous Leg Ulcer (VLU) Treatment Market Size, Share & Growth, 2026
A 61-Year-Old Woman With Leg Ulcers
Diabetic Leg Ulcers: Home Remedies to Heal Leg Sores
Chronic venous leg ulcers - nmmra.org
Leg Ulcer Service - North Tees and Hartlepool NHS Foundation Trust
A 'test and treat' strategy for elevated wound protease activity for healing in venous leg ulcers | Cochrane
Local treatment of a chronic leg ulcer with GM-CSF in a patient with HIV infection. | Sexually Transmitted Infections
Who is working on investigational drugs for Leg Ulcer? Patents, clinical trials, drugs in development
Intermittent pneumatic compression for treating venous leg ulcers » AISLeC
Qualitative bacteriology and chronic leg ulcer healing<...
Delivery of Compression Therapy for Venous Leg Ulcers | JN Learning | AMA Ed Hub
Leg-Ulcer
Table of Contents | Ulcers | Hindawi
Simplifying venous leg ulcer management
Leg Ulcers
A qualitative study on the patient's narrative in the progression of chronic venous disease into a first venous leg ulcer | HU...
Living with a Venous Leg Ulcer
The Leg Ulcer Charity - The Whiteley Clinic
Wound Essentials 4: Bilateral leg ulcer of unknown origin treated with honey and bandaging - Wounds UK
Bruce Springsteen Is in 'Great Shape' amid Peptic Ulcer Disease Recovery, Steven Van Zandt Says (Exclusive)
Venous Leg Ulcer Study - ROYAL RESEARCH CORP
Leg Ulcers Treatment | Veincentre
Management of leg ulcers
Two Day Leg Ulcer Study Days - Training Hub
Ankle15
- Best practice determines that a patient with a lower limb ulcer between the knee and the ankle in the presence of venous disease must be diagnosed and treated within two weeks. (nice.org.uk)
- This small wound is perfect for adhering at the ankle or lower leg and adheres by itself. (anatomywarehouse.com)
- She was previously diagnosed with chronic venous insufficiency through assessment of medical history, leg, ulcer, symptoms & ankle brachial pulse index (ABPI) measurement. (nmmra.org)
- Usually developing on the inside of the leg, just above the ankle, an ulcer can be painful and cause the whole leg to swell. (nth.nhs.uk)
- Venous leg ulcers are wounds that develop on the ankle or leg due to damaged or abnormal veins. (fortlauderdalesbestrhinoplasty.com)
- Venous ulcers occur on the inner surface of the leg a few centimeters from the ankle joint. (leahsfitness.com)
- Venous ulcers are typically shallow, have an irregular shape, and appear near bony parts of the body, such as the ankle. (medicalnewstoday.com)
- Venous skin ulcers that may appear on the lower leg, above the calf or on the lower ankle usually cause achy and swollen legs. (wikipedia.org)
- Tension is difficult to control in a fabric, which naturally produces uneven pressure across the surface of the leg - from high pressure at the ankle and shin to no pressure at all on hollow sections, for example, at the Achilles Tendon. (bap-medical.com)
- A leg ulcer is an open sore or wound that evolves on the skin of the leg, generally below the knee and above the ankle. (debrabernier.com)
- The swelling will typically occur throughout the ankle or foot but could extend up the leg into the calf or above the knee in severe cases. (spartzvein.com)
- Most venous ulcers occur on the leg, above the ankle. (com.ng)
- These ulcers often occur on bony areas like the ankle. (healthprep.com)
- Seven days after the bite, necrosis and skin sloughing developed, and his entire leg and ankle were red and edematous. (cdc.gov)
- 9.4% reported foot/ankle pain and 6.4% lower leg pain. (cdc.gov)
Heal26
- Ulcers are wounds or open sores that will not heal. (upmc.com)
- Although most leg ulcers will clear up with good nursing care, a significant proportion of the lesions will take 12 months or longer to heal. (scienceblog.com)
- The researchers concentrated on 'hard to heal' ulcers that had not cleared up after six months or longer. (scienceblog.com)
- 1. The paper: 'Use of weekly, low dose high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised control trial', is available online in advance of publication in the British Medical Journal (BMJ 2011;342:d1092). (scienceblog.com)
- One of the best remedies to heal dangerous leg ulcers happens to be activated charcoal. (earthclinic.com)
- A leg ulcer is a long-lasting sore that takes more than two weeks to heal. (nth.nhs.uk)
- These treatments are based on some evidence that a proportion of slow to heal ulcers have elevated protease activity in the wound. (cochrane.org)
- I couldn't exercise, so the weight just piled on and made it even harder for my leg to heal. (legsmatter.org)
- They really went out of their way to make sure that my leg ulcers got the right kind of treatment and to heal them. (legsmatter.org)
- If you develop these symptoms or if the ulcer does not heal within two weeks, you should seek medical attention. (leahsfitness.com)
- This, in turn, can lead to the formation of painful ulcers that are slow to heal or may not heal at all. (medicalnewstoday.com)
- The goal of wound care management is to encourage the ulcers to heal more quickly. (ulcertalk.com)
- Your doctor may ask you to take one of these medications to help your ulcer heal more quickly. (ulcertalk.com)
- Artificial skin , made of collagen and cultured skin cells, is also used to cover venous ulcers and excrete growth factors to help them heal. (ulcertalk.com)
- Ulcers that heal within 12 weeks are usually classified as acute, and longer-lasting ones as chronic. (wikipedia.org)
- What Is the Fastest Way to Heal a Leg Ulcer? (debrabernier.com)
- These ulcers can be painful, sluggish to heal, and can have a significant effect on a person's quality of life. (debrabernier.com)
- After studying this, you will explore the causes of leg ulcers and the fastest and most effective ways to heal a leg ulcer. (debrabernier.com)
- Effectively managing and controlling the infection can aid create more favorable surroundings for the ulcer to heal. (debrabernier.com)
- In order to heal ulcerated legs fast with creams, you need to find a cream that is right for your skin type. (big.guide)
- Ulcers can be difficult to heal and in serious instances, don't heal at all. (spartzvein.com)
- If ulcers do not heal well, your provider may recommend certain procedures or surgery to improve blood flow through your veins. (com.ng)
- Venous leg ulcers are sores that develop on the leg and heal very slowly, typically due to poor circulation through the limb. (healthprep.com)
- As the ulcer takes an increased amount of time to heal, be sure to intermittently replace the bandage and make sure the wound is still clean. (healthprep.com)
- Since venous leg ulcers heal slowly because of poor circulation, the best treatment method is to address the circulatory problem. (healthprep.com)
- ever had an ulcer or sore on {your/his/her} leg or foot that took more than 4 weeks to heal? (cdc.gov)
Wounds8
- If not treated early enough, venous leg ulcers can turn into extremely large wounds, which are open to infections. (fortlauderdalesbestrhinoplasty.com)
- This deficiency can lead to poorly healing wounds in the long run, which are known by a number of names, such as leg ulcer, venous leg ulcer, or open leg (ulcus cruris). (jobstcanada.com)
- Bloody (sanguineous), usually seen in malignant ulcers and in healing ulcers with healthy granulation tissue Seropurulent Serosanguinous Serous with sulphur granules, seen in actinomycosis Yellowish, as seen in tuberculous ulcer The wounds from which ulcers arise can be caused by a wide variety of factors, but the main cause is impaired blood circulation. (wikipedia.org)
- Especially, chronic wounds and ulcers are caused by poor circulation, either through cardiovascular issues or external pressure from a bed or a wheelchair. (wikipedia.org)
- Blood disorders and chronic wounds can result in skin ulcers as well. (wikipedia.org)
- Electromagnetic therapy (EMT) is sometimes used as a treatment to assist the healing of chronic wounds such as venous leg ulcers. (altmetric.com)
- Adding cream to ulcer wounds can help reduce pain and encourage healing by providing topical support for the damaged area. (big.guide)
- Tinea capitis was found in 48 subjects, scabies in 24, and leg ulcers from infected wounds in 33. (cdc.gov)
Foot Ulcers7
- With new ways of treating leg ulcers, future foot ulcers can be prevented while preventing complications. (big.guide)
- Wearing shoes with good traction is an important preventive measure against foot ulcers. (big.guide)
- About one-third of diabetic patients develop foot ulcers in their lifetime. (who.int)
- While the lifetime incidence of foot ulcers in leprosy is not known, an ongoing cross-sectional study on the prevalence of disabilities due to leprosy has shown that over 30% of patients with an anesthetic foot presented with a plantar ulcer. (who.int)
- Foot ulcers reduce patient mobility, social interaction, and health-related quality of life. (who.int)
- The treatment of foot ulcers increases the substantial burden on healthcare. (who.int)
- Therefore, proper management and expedited healing of foot ulcers are important to limit the burden of ulcer care. (who.int)
Deep vein throm3
- These include an underlying condition such as varicose veins, skin ulcer, venous thrombosis, deep vein thrombosis, and many others. (fortlauderdalesbestrhinoplasty.com)
- In addition, deep vein thrombosis, arterial insufficiency, diabetes mellitus, infections, and other less frequent causes are involved in the development of venous leg ulcers. (jobstcanada.com)
- People who have suffered from deep vein thrombosis in the past are at risk of getting venous ulcers because this condition affects the valves in the legs making the blood get stasis. (leahsfitness.com)
Blood clots4
- Leg ulcers, for me, are so much worse than blood clots. (legsmatter.org)
- This is especially important for people with venous insufficiency, as blood clots can aggravate the condition and problematize the healing of ulcers. (debrabernier.com)
- This helps prevent leg swelling and, to a lesser extent, blood clots. (medlineplus.gov)
- It commonly includes symptoms such as "heavy" or painful legs, but there can more rarely have more serious consequences such as skin ulcers, blood clots, and chronic venous stasis disease. (cdc.gov)
Sores5
- Among the more significant side effects of diabetes are diabetic leg ulcers, open leg sores that may afflict the feet or legs, once or recurrently, and break down the skin's protective barrier so that infection may more easily enter the body to cause disease and further tissue damage at the site of the ulcer. (earthclinic.com)
- NHS Choices (2012a) define leg ulcers as sores below the knee that are non-healing by six weeks. (nmmra.org)
- A very common and dangerous type of skin ulcer is caused by what are called pressure-sensitive sores, more commonly called bed sores, which are frequent in people who are bedridden or who use wheelchairs for long periods. (wikipedia.org)
- Venous ulcers (open sores) can occur when the veins in your legs do not push blood back up to your heart as well as they should. (com.ng)
- You have a sudden increase in leg pain or swelling, fever, redness of the leg, or leg sores. (medlineplus.gov)
Stasis2
- Stasis of blood inside the leg veins can damage the veins making them get ulcers. (leahsfitness.com)
- Venous ulcers (also called stasis or varicose ulcers) comprise 80% to 85% of all leg ulcers. (altmetric.com)
Recurrence7
- Two primary qualitative studies explored the perspectives and experiences of people engaged with compression garments as part of their maintenance therapy to prevent venous leg ulcer recurrence. (cadth.ca)
- No mixed-methods studies exploring the use of compression garments as either part of maintenance therapy to prevent venous leg ulcer recurrence or as part of the process of treating venous leg ulcers were reviewed. (cadth.ca)
- Agnes presented with recurrence of an ulcer on the medial gaiter region of her left leg. (nmmra.org)
- This followed an earlier study 2 that had shown that traditional surgical correction of superficial venous reflux in addition to compression bandaging does not improve ulcer healing but reduces the recurrence of ulcers at four years and results in a greater proportion of ulcer-free time. (veincentre.com)
- Although this earlier study had shown that surgical correction of venous insufficiency reduced recurrence, the fact that it also showed no improvement in ulcer healing held back the most effective treatment of venous leg ulcers by many years. (veincentre.com)
- Surgical removal of incompetent veins reduces the risk of ulcer recurrence . (bvsalud.org)
- To determine the effects of superficial endovenous ablation on the healing and recurrence of venous leg ulcers and the quality of life of people with venous ulcer disease . (bvsalud.org)
Symptoms of venous ulcers1
- Different people get different severity of the symptoms of venous ulcers but Dr. Autumn Savage has a long, positive track record in treating venous ulcers with varying severity. (leahsfitness.com)
Wound care3
- Compression therapy is an important part of treatment for venous leg ulcers, alongside the latest wound care options such as the Cutimed product range. (jobstcanada.com)
- Wound care is an important part of treatment for venous ulcers. (ulcertalk.com)
- If you are at risk for venous ulcers, take the steps listed above under Wound Care. (com.ng)
Painful8
- These ulcers can be painful and unsightly, having a significant negative impact on health and quality of life. (scienceblog.com)
- it's also very painful and caused inflammation to my right leg, that walking short distance is avoided. (earthclinic.com)
- Venous leg ulcers can be very painful and uncomfortable, especially when infected. (fortlauderdalesbestrhinoplasty.com)
- Most ulcers begin with a small, itchy inflammation on the affected area, which will then grow to become a large, painful wound with a severely exposed tissue. (fortlauderdalesbestrhinoplasty.com)
- Chronic ulcers may be painful. (wikipedia.org)
- These ulcers usually last from 7 to 14 days and can be painful. (wikipedia.org)
- Leg ulcers can be a formidable and painful condition to deal with. (debrabernier.com)
- Ulcerated legs can be a painful experience. (big.guide)
Arterial4
- The atherosclerosis that blocks leg arteries causes arterial insufficiency, a lack of circulation to the area where ulcers subsequently occur. (earthclinic.com)
- They advise that different ulcers such as diabetic, traumatic & arterial ulcers can occur however Brown (2011) states around 80% of ulcers are venous. (nmmra.org)
- Venous and arterial ulcers are both types of ischemic ulcers, which describes ulcers that occur due to a lack of blood flow in general. (medicalnewstoday.com)
- However, venous ulcers occur specifically due to problems with veins, while arterial ulcers occur due to problems with arteries. (medicalnewstoday.com)
Chronic venous leg2
- This essay will examine the nursing process involved in managing chronic venous leg ulcers (CVLU). (nmmra.org)
- However, chronic venous leg ulcer, an open wound on the leg, is the most severe manifestation of this disorder. (jobstcanada.com)
Healing of venous1
- A systematic review found that bilayer artificial skin with compression bandaging is useful in the healing of venous ulcers when compared to simple dressings. (ulcertalk.com)
Suffer from venous2
- If you suffer from venous leg ulcers, you should also do plenty of exercise to stimulate blood circulation by activating the calf muscle pump. (jobstcanada.com)
- Physically inactive people suffer from venous ulcers because the calf muscles that help to pump blood back to the heart are weak. (leahsfitness.com)
Development of venous1
- If you fall under the high-risk category, you should take safety measures to prevent the development of venous ulcers . (leahsfitness.com)
People with leg ulcers1
- It is quite unfortunate the fact that many people with leg ulcers choose not to do something about their condition until it is too late. (fortlauderdalesbestrhinoplasty.com)
Prevalence of leg ulcers2
- The prevalence of leg ulcers is increasing 5 . (nice.org.uk)
- The estimated prevalence of leg ulcers in the UK population is 1.5 to 3 per 1000. (altmetric.com)
Treatments10
- A 'test and treat' strategy involves testing for elevated proteases and then using protease-modulating treatments in ulcers which show elevated protease levels. (cochrane.org)
- Research is still needed to find out if it is helpful to test venous leg ulcers for high levels of protease activity and then treat high levels using protease-modulating treatments. (cochrane.org)
- This review is part of a set of reviews investigating different aspects of using protease-modulating treatments in people with venous leg ulcers. (cochrane.org)
- The use of protease-modulating treatments for venous leg ulcers is increasing. (cochrane.org)
- Many leg ulcer removal specialists today offer laser removal on top of other treatments. (fortlauderdalesbestrhinoplasty.com)
- Despite being very efficient and effective, laser leg ulcer removal remains to be just as affordable as the traditional treatments for venous ulcers. (fortlauderdalesbestrhinoplasty.com)
- This article explores ischemic ulcers and provides an overview of their symptoms, causes, and treatments. (medicalnewstoday.com)
- Skin grafts and surgery can be employed to treat or cure leg ulcers, especially when other conventional treatments have been unsuccessful. (debrabernier.com)
- W e can help clients all over Minneapolis with leg pain treatments. (spartzvein.com)
- The most common treatments to address a venous leg ulcer are compression socks and bandages. (healthprep.com)
Insufficiency7
- This self-adhesive wound represents a venous leg ulcer, a substance defect in the tissue of the lower leg as a result of a chronic venous insufficiency. (anatomywarehouse.com)
- Venous insufficiency is the most significant cause of leg ulcers. (jobstcanada.com)
- Venous insufficiency can usher in the growth of leg ulcers due to its impact on the blood circulation within the veins of the legs. (debrabernier.com)
- This is called venous insufficiency, This leads to high pressure in the lower leg veins. (com.ng)
- Venous insufficiency is a condition in which the veins have problems sending blood from the legs back to the heart. (medlineplus.gov)
- Risks from static standing: There are numerous potential health risks from prolonged standing or walking on hard surfaces, such as lower back pain, leg pain and discomfort, fatigue, lower-extremity swelling, varicose veins, chronic venous insufficiency (see below), and (more rarely) a poorer prognosis after diagnosis of coronary artery disease and preterm births. (cdc.gov)
- Chronic Venous Insufficiency is a common condition that involves problems with the return of blood from the legs back up to the heart, often as a result of defective valves in the leg. (cdc.gov)
Dressings3
- Drawing on patients from across the UK and Ireland, they found that adding ultrasound to the standard approach to care - dressings and compression therapy - made no difference to the speed of healing or the chance of the ulcers coming back. (scienceblog.com)
- In January 2019, NICE published positive guidance MTG42 for adopting Urgostart dressings for venous leg ulcers (VLU). (nice.org.uk)
- They tried different dressings and different ways of wrapping my legs. (legsmatter.org)
Heals4
- When applied on to an open ulcer, its purpose is to absorb as much waste material or toxins as much as possible so that when the ulcer heals there no unwanted toxins or materail are trapped inside as the wound heals. (earthclinic.com)
- Once the ulcer heals, you would benefit from wearing compression stockings , as they help reduce leg swelling by helping blood flow back to the heart. (veincentre.com)
- With venous leg ulcers, the itching lasts much longer due to the delayed healing process, and your skin may become dry and flaky as it heals. (healthprep.com)
- The patient will be followed up for 8 weeks and photographs of ulcers will be taken at baseline and after every 2 weeks until the ulcer heals or at 8 weeks, whichever is earlier, to measure the ulcer area. (who.int)
Occur6
- These ulcers often occur with advanced diabetes because the diabetic patient does not feel the damage occurring to the skin, where neuropathy has affected pain receptors in the legs and feet. (earthclinic.com)
- CVLU occur when blood in the lower extremities cannot adequately return to the heart causing hypertension & congestion in the legs. (nmmra.org)
- Venous leg ulcers are the most frequent types of ulcers and occur secondary to trauma in the legs. (leahsfitness.com)
- Venous leg ulcers occur when the leg of a susceptible person gets an injury which creates pressure inside the veins that makes the overlying skin form an ulcer. (leahsfitness.com)
- Where do ischemic ulcers occur? (medicalnewstoday.com)
- It may also occur as the result of a past blood clot in the legs. (medlineplus.gov)
Decubitus ulcers1
- This stress in the blood circulation is transformed to a skin ulcer, commonly known as bedsores or decubitus ulcers. (wikipedia.org)
Treat leg ulcers2
- The NHS continues to treat leg ulcers with a process of cleaning and dressing the affected area, committing the patient to a lengthy period in compression bandages to theoretically help improve circulation and to treat swelling. (veincentre.com)
- The most common way to treat leg ulcers is to use topical medications or oral antibiotics. (big.guide)
Treatment22
- Treatment includes controlling the pressure in the leg veins by elevation of the limb, compression therapy and use of an appropriate dressing. (nice.org.uk)
- The challenge was to develop a leg ulcer pathway to include cost-effective, evidence-based treatment strategies to facilitate the delivery of high-quality care, guiding clinicians to improve patient healing outcomes. (nice.org.uk)
- A 61-year-old woman presents to the wound center for continued treatment of venous leg ulcers complicated by diabetes mellitus . (medscape.com)
- As one more option, phototherapy offers a promising alternative medicine treatment for diabetic leg ulcers. (earthclinic.com)
- I have a pretty agressive ulcer and have given up on conventional medical treatment and looking for an alternative. (earthclinic.com)
- Treatment can include regular cleaning and dressing of the ulcer. (nth.nhs.uk)
- It is important to know if using both the test and the treatment together can improve healing of leg ulcers. (cochrane.org)
- In January 2016 we searched for as many relevant studies as possible that were randomised controlled trials, and which compared a 'test and treat' strategy with another treatment in people with venous leg ulcers. (cochrane.org)
- To determine the effects on venous leg ulcer healing of a 'test and treat' strategy involving detection of high levels of wound protease activity and treatment with protease-modulating therapies, compared with alternative treatment strategies such as using the same treatment for all participants or using a different method of treatment selection. (cochrane.org)
- Published or unpublished RCTs which assessed a test and treat strategy for elevated protease activity in venous leg ulcers in adults compared with an alternative treatment strategy. (cochrane.org)
- Local treatment of a chronic leg ulcer with GM-CSF in a patient with HIV infection. (bmj.com)
- Many countries have published guidelines, which state that compression therapy is the 'gold standard' treatment for venous leg ulcers 1-11. (linkforwoundhealing.info)
- In our experience, leg ulcers tend to remain healed following this treatment pathway. (veincentre.com)
- For example, if a person has diabetes, their treatment plan may include strategies to keep the ulcer clean and protected, medications to control blood sugar, and changes to their diet. (medicalnewstoday.com)
- As an in-depth report, it covers all details inside analysis and opinions in Venous Leg Ulcers Treatment industry. (radiantinsights.com)
- As the compression in PneumaSox isn't contingent on the leg's shape, it presents an optimal treatment solution for venous leg ulcers (also in the malleolus area). (bap-medical.com)
- The healing time of a leg ulcer changes based on the harshness of the ulcer and how well it responds to treatment. (debrabernier.com)
- Compression therapy is a widely utilized and effective treatment for healing leg ulcers. (debrabernier.com)
- Our Minneapolis vein clinic's leg swelling treatment options can combat venous disease and help return your life to normal. (spartzvein.com)
- We offer venous leg ulcer treatment services to help ease your pain, improving your quality of life. (spartzvein.com)
- This is a common treatment for circulatory issues and swelling in the legs. (healthprep.com)
- Both trials randomised participants to endovenous treatment and compression or compression alone, however the compression alone group in the EVRA trial received deferred endovenous treatment (after ulcer healing or from six months). (bvsalud.org)
Lower extremity1
- Leg ulcers are a type of skin wound from the skin-substance barrier that can develop on any part of the lower extremity. (big.guide)
Varicose veins1
- Venous leg ulcers are common in people with varicose veins or mobility problems whose 'muscle pumps' in the feet and calves struggle to drive blood up to the heart. (scienceblog.com)
Sore2
- An ischemic ulcer is a type of wound or sore that develops when the arteries do not deliver enough blood flow to a specific area. (medicalnewstoday.com)
- An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. (wikipedia.org)
Redness2
- If these ulcers become infected they may develop an unpleasant odour, increased tenderness and redness. (wikipedia.org)
- It can also help reduce symptoms such as pain and redness associated with leg ulcers. (big.guide)
Endovenous ablation2
- Endovenous ablation for venous leg ulcers. (bvsalud.org)
- When used with compression, endovenous ablation aims to further reduce pressure in the veins of the leg , which may impact ulcer healing. (bvsalud.org)
Infection9
- Our professional leg ulcer team offers an expert service to minimise the risk of infection and ensure leg ulcer patients can recover as quickly as possible. (nth.nhs.uk)
- At this point, you may need to have the affected leg cut in order to prevent the infection from getting into the bloodstream and traveling to other parts of your body such as your brain. (fortlauderdalesbestrhinoplasty.com)
- If you are lucky enough in the sense that the infection can still be eliminated without having the affected leg cut off, you may be in for what we call skin grafting. (fortlauderdalesbestrhinoplasty.com)
- These ulcers are red, and when they have a secondary infection, they produce a yellow or green discharge. (leahsfitness.com)
- This is often done if the ulcer shows signs of infection. (ulcertalk.com)
- Managing infection is a crucial aspect of enabling the healing of leg ulcers. (debrabernier.com)
- Skin grafts restock new skin cells and enable the ulcer healing process, relieve pain, and minimize the chance of infection. (debrabernier.com)
- To clean the ulcer, run it under cold water with a damp washcloth before using an anti-infection cream. (healthprep.com)
- Therefore, in addition to removing any infection, an effective way to promote the healing of ulcers is rest - either complete bed rest, which is rarely possible or, commonly, rest to the affected part using an off-loading method. (who.int)
Veins in your legs2
- Noticeably enlarged or swollen veins in your legs. (fortlauderdalesbestrhinoplasty.com)
- It would help if you managed your weight because excess weight can trigger venous ulcers by putting pressure on the veins in your legs. (leahsfitness.com)
Ulceration4
- A five-year study led from the University of Leeds has shown that ultrasound therapy does nothing to speed up the healing process of leg ulceration - contrary to what had been expected. (scienceblog.com)
- Leg ulceration is a common, chronic, recurring condition. (altmetric.com)
- To determine the pattern of bacterial pathogens and their antibiotic sensitivity profile in patients with infected chronic leg ulceration. (bvsalud.org)
- The ulceration continued to enlarge, and swelling of the leg and toes impaired walking. (cdc.gov)
Skin ulcer1
- A skin ulcer is often visible in the event of exposure to heat or cold, irritation, or a problem with blood circulation. (wikipedia.org)
Elevate your legs3
- If you are bedridden or you have a disease that makes you inactive, you should elevate your legs to stimulate blood to flow back to the heart. (leahsfitness.com)
- Some of the ways to avoid venous ulcers are to elevate your legs, manage your weight, and to exercise regularly. (leahsfitness.com)
- You can elevate your legs by laying in bed with your legs on a pile of pillows, or otherwise putting your legs on a surface raised higher than your head. (healthprep.com)
Diabetic foot1
- About 26 million people worldwide annually have a diabetic foot ulcer with another 130 million at risk of diabetic neuropathy. (who.int)
Patients9
- The best prescription for patients with venous leg ulcers is good quality nursing care - and the occasional belly laugh! (scienceblog.com)
- The key to care with this group of patients is to stimulate blood flow back up the legs to the heart. (scienceblog.com)
- We do need to find ways to helping those patients who ulcers won't go away, but our study shows that ultrasound is not the way to do that. (scienceblog.com)
- The audit findings showed there was no structured approach to managing leg ulcers, dressing regimes were ad-hoc with frequent regime changes, documentation did not always reflect the progression of the wound and some patients were kept in clinic for long periods without review of the diagnosis and escalation to other specialist services. (nice.org.uk)
- For registered nurses and experienced Health Care Assistants who are involved in the care of patients with leg ulcers. (cptraininghub.nhs.uk)
- Patients may feel pain on the skin around the ulcer, and fluid may ooze from the ulcer. (wikipedia.org)
- It is estimated that about 50% of patients with leg ulcers also have diabetes. (big.guide)
- Sixty swab specimens obtained from chronic leg ulcer (CLU) patients were cultured aerobically and the antibiotic sensitivity pattern of the recovered organisms determined by the modified Kirby -Bauer disc- diffusion method . (bvsalud.org)
- Though the actual burden of ulcers in leprosy is unknown, it is estimated that over 3 million people are living with disability due to leprosy and that 20-50% of patients with peripheral neuropathy due to leprosy will experience ulcers. (who.int)
20161
- Positive pilot outcomes and positive feedback from clinical staff led to the development in a leg ulcer pathway in 2016. (nice.org.uk)
Open wound1
- Leg ulcers are an open wound on the skin of the lower leg. (big.guide)
Below the knee1
- These ulcers are almost always located below the knee and can affect one or both legs. (leahsfitness.com)
Ankles2
- I had leg ulcers on both on my ankles, so it made it really hard for me to manoeuvre my feet to walk. (legsmatter.org)
- Also, check your feet and legs every day: the tops and bottoms, ankles, and heels. (com.ng)
Compression stockings3
- People who have had venous ulcers in the past can reduce the risk of getting another ulcer by wearing compression stockings. (leahsfitness.com)
- You can wear compression stockings to improve blood flow in your legs. (medlineplus.gov)
- Compression stockings gently squeeze your legs to move blood up your legs. (medlineplus.gov)
Itchy1
- Before the ulcer establishes definitively, there may be a dark red or purple skin over the affected area as well as a thickening, drying, and itchy skin. (wikipedia.org)
VLUs3
- The group recognised that a very high proportion of all leg ulcers have venous disease as a causative or contributory factor (i.e. are VLUs or mixed aetiology ulcers) and so may be appropriate for compression therapy. (linkforwoundhealing.info)
- Everyone involved in wound healing should be ambitious in striving for a step change that decisively overturns passivity in expecting lengthy, delayed or non-healing of VLUs and other leg ulcers associated with venous disease. (linkforwoundhealing.info)
- Venous leg ulcers (VLUs) are a serious manifestation of chronic venous disease affecting up to 3% of the adult population . (bvsalud.org)
Circulation2
- Venous leg ulcers due to impaired circulation or a blood flow disorder are more common in the elderly. (wikipedia.org)
- These stockings gently compress the legs and narrow blood vessels, causing blood circulation to improve. (healthprep.com)
DermIS1
- Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. (wikipedia.org)
Bilateral1
- An 82-year-old female presented with bilateral leg ulcers of unknown origin. (wounds-uk.com)
Peripheral vascula1
- Ulcers are also more likely to develop in people over the age of 60 who are living with diabetes, high blood pressure, or peripheral vascular disease. (big.guide)