Lentigo
Hutchinson's Melanotic Freckle
Hyperpigmentation
LEOPARD Syndrome
Facial Neoplasms
Melanosis
Cafe-au-Lait Spots
Nevus
Palatal Neoplasms
Hypopigmentation
Noonan Syndrome
Dermoscopy
Nevus, Pigmented
Melanoma
Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. (1/29)
Expression of activated leukocyte cell adhesion molecule (ALCAM)/CD166 correlates with the aggregation and metastatic capacity of human melanoma cell lines (Am J Pathol 1998, 152:805-813). Immunohistochemistry on a series of human melanocytic lesions reveals that ALCAM expression correlates with melanoma progression. Most nevi (34/38) and all thin melanomas studied (Clark levels I and II) did not express ALCAM. In contrast, immunoreactivity was detected in the invasive, vertical growth phase of 2 of the 13 Clark level III lesions tested. The fraction of positive lesions further increased in Clark level IV (13/19) and in Clark level V (4/4) lesions. ALCAM expression was exclusively detectable in the vertical growth phase of the primary tumor. In melanoma metastases, approximately half of the lesions tested (13/28) were ALCAM positive. According to the Breslow-thickness, ALCAM expression was observed in less than 10% of the lesions that were thinner than 1.5 mm and in over 70% of the lesions that were thicker than 1.5 mm. Our results strongly suggest that ALCAM plays an important role in melanocytic tumor progression and depict it as a new molecular marker for neoplastic progression of primary human melanoma. (+info)The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. (2/29)
Little is known about the mechanism(s) underlying hyperpigmentation in lentigo senilis. We have previously reported that keratinocyte-derived endothelins are intrinsic paracrine mitogens and melanogens for human melanocytes and that they play an essential role in stimulating ultraviolet-B-induced melanogenesis. In this study, we have used immunohistochemistry and reverse transcriptase polymerase chain reaction analysis to clarify the role of the endothelin cascade, including endothelin production, processing by endothelin-converting enzyme, and expression of the endothelin B receptor, in the hyperpigmentary mechanism(s) involved in lentigo senilis. The number of tyrosinase immunopositive melanocytes in lentigo senilis lesional skin was increased 2-fold over the perilesional epidermis. Immunohistochemistry using antibodies to endothelin-1 demonstrated relatively stronger staining in the lesional epidermis than in the perilesional epidermis. Reverse transcriptase polymerase chain reaction analysis concomitantly demonstrated accentuated expression of transcripts for endothelin-1 and for the endothelin B receptor in lentigo senilis lesional skin, which was accompanied by a similar accentuated expression of tyrosinase mRNA compared with the perilesional control. The endothelin-1-inducible cytokine, tumor necrosis factor alpha, was consistently upregulated in the lentigo senilis lesional epidermis as determined at the transcriptional level and by immunostaining, whereas interleukin-1alpha was downregulated. In contrast, endothelin-converting enzyme 1alpha mRNA was not substantially increased in the lesional epidermis. These findings suggest that an accentuation of the epidermal endothelin cascade, especially with respect to expression of endothelin and the endothelin B receptor, plays an important role in the mechanism involved in the hyperpigmentation of lentigo senilis. (+info)The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation. (3/29)
We previously reported that accentuated expression of the endothelin-1 (ET-1)/endothelin B receptor (ET(B)R) cascade is involved in the mechanism of hyperpigmentation in lentigo senilis (LS) lesions. The paracrine mechanism underlying ultraviolet B (UVB)-induced hyperpigmentation in the skin may involve the stimulation of the ET-1/ET(B)R cascade as well as the stem cell factor (SCF)/SCF receptor cascade. Therefore, we used RT-PCR and immunohistochemistry to determine whether accentuated expression of the SCF/SCF receptor cascade is also associated with the mechanism of hyperpigmentation in epidermal LS lesions. RT-PCR analysis demonstrated the increased expression of mRNA transcripts for SCF (n=7), but not for SCF receptor (n=6) or growth-related oncogene alpha (GROalpha) (n=4) in LS lesions. Immunohistochemistry revealed markedly stronger staining for SCF but not for GROalpha or basic fibroblast growth factor (bFGF) in the lesional epidermis compared with the perilesional epidermis. This increased staining for SCF was corroborated by western blotting analysis for SCF expression in the lesional epidermis. These findings suggest that in addition to the stimulated expression of the ET-1/ET(B)R cascade, the accentuated expression of SCF in lesional skin plays an important role in the mechanism involved in the epidermal hyperpigmentation of LS. (+info)Colocalized nevus depigmentosus and lentigines with underlying breast hypoplasia: a case of reverse mutation? (4/29)
Nevus depigmentosus (ND) is classically defined as a congenital nonprogressive hypopigmented macule, stable in size and distribution. There have been many reports of colocalization of ND and lentigines. We describe development of multiple lentigines over ND in a 9-year-old girl along with hypoplasia of the underlying breast. The case is being reported to highlight the phenotypic manifestation of reverse mutation and the coincidental breast hypoplasia that has not been reported before. (+info)The use of lasers and intense pulsed light sources for the treatment of pigmentary lesions. (5/29)
Lasers and intense pulsed light sources are frequently used for the treatment of pigmented lesions, and the appropriate selection of devices for different lesions is vital to achieving satisfactory clinical outcomes. In dark-skinned patients, the risk of post-inflammatory hyperpigmentation is of particular importance. In general, long-pulse laser and intense pulsed light sources can be effective with a low risk of post-inflammatory hyperpigmentation (PIH) when used for the treatment of lentigines. However, for dermal pigmentation and tattoo, Q-switched lasers are effective, with a lower risk of complications. In the removal of melanocytic nevi, a combined approach with a long-pulse pigmented laser and a Q-switched laser is particularly applicable. (+info)The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis. (6/29)
Familial lentiginosis syndromes cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous lentigines unassociated with systemic disease, to associations with several syndromes carrying increased risk of formation of hamartomas, hyperplasias, and other neoplasms. The molecular pathways involved in the aetiology of these syndromes have recently been more clearly defined and several major cellular signalling pathways are probably involved: the protein kinase A (PKA) pathway in Carney complex (CNC), the Ras/Erk MAP kinase pathway in LEOPARD/Noonan syndromes, and the mammalian target of rapamycin pathway (mTOR) in Peutz-Jeghers syndrome and the diseases caused by PTEN mutations. Here we discuss the clinical presentation of these disorders and discuss the molecular mechanisms involved. The presence of lentigines in these diseases caused by diverse molecular defects is probably more than an associated clinical feature and likely reflects cross talk and convergence of signalling pathways of central importance to embryogenesis, neural crest differentiation, and end-organ growth and function of a broad range of tissues including those of the endocrine, reproductive, gastrointestinal, cardiac, and integument systems. (+info)Lentiginous melanoma: a histologic pattern of melanoma to be distinguished from lentiginous nevus. (7/29)
Atypical lentiginous melanocytic proliferations in elderly patients continue to pose a diagnostic dilemma with lesions variably categorized as dysplastic nevus, atypical junctional nevus, melanoma in situ (early or evolving) and premalignant melanosis. We present pigmented lesions from 16 patients (seven male and nine female) and with the exception of one case, all were older than 50 years of age. The anatomical sites included trunk (7), head and neck (6) and upper extremity (3). The clinical diagnosis was variable and included lentigo maligna, atypical nevus, pigmented basal cell carcinoma, seborrheic keratosis and lentigo. The initial biopsies mimicked lentiginous nevus or dysplastic nevus and were characterized by a lentiginous proliferation of melanocytes at the dermoepidermal junction both as single cells and as small nests with areas of confluent growth, extending to the edges of the biopsy. The retiform epidermis was maintained and pagetoid spread of melanocytes was not prominent in hematoxylin- and eosin- stained sections. Dermal fibrosis was variably present and the melanocytic proliferation demonstrated cytological atypia. The subsequent re-excisions demonstrated similar atypical melanocytic proliferation occurring over a broad area flanking the prior biopsy sites. The diagnosis of melanoma was more easily recognized in the complete excision specimens. Immunohistochemical stains for Mitf and Mart-1 highlighted the extent of the basalar melanocytic proliferation as well as foci of pagetoid spread by melanocytes. Familiarity with this pattern of early melanoma should facilitate proper classification of lentiginous melanocytic proliferations in biopsies from older adults. (+info)Metastasis of a malignant melanoma 2 years after carbon dioxide laser treatment of a pigmented lesion: case report and review of the literature. (8/29)
A 64-year-old woman with a clinically diagnosed 'lentigo simplex' on her right cheek was dermatologically treated several times with a CO2 laser. Three years later she showed a metastasis of a malignant melanoma in her right parotid gland. Considering this case, as well as other published cases reporting malignant melanomas occurring after laser treatment, we again underscore that naevomelanocytic lesions are not a routine indication for laser treatment. (+info)A lentigo is a small, sharply defined, pigmented macule (flat spot) on the skin. It's usually tan, brown, or black and can appear on various parts of the body, particularly where the skin has been exposed to the sun. Lentigos are typically harmless and don't require treatment unless they're uncomfortable or for cosmetic reasons. However, some types of lentigines, such as lentigo maligna, can progress into melanoma, a type of skin cancer, so regular self-examinations and professional skin checks are important.
It is essential to differentiate between simple lentigos and lentigo maligna, which is a precancerous lesion. Lentigo maligna tends to occur in older individuals, often on the face, and can appear as a large, irregularly shaped, and darkly pigmented patch. A dermatologist should evaluate any suspicious or changing skin spots for proper diagnosis and treatment.
Hutchinson's melanotic freckle, also known as Hutchinson's melanotic macule or naevus, is a type of pigmented lesion that can be a precursor to malignant melanoma, a serious form of skin cancer. It is typically characterized by the presence of darkly pigmented, irregularly shaped patches on the skin, often found on the face or neck.
The lesions are usually brown or black in color and may have an uneven border or surface. They can vary in size from a few millimeters to several centimeters in diameter. Hutchinson's melanotic freckles are typically larger, darker, and more irregularly shaped than common freckles.
These lesions are named after Sir Jonathan Hutchinson, an English surgeon and pathologist who first described them in the late 19th century. It is important to note that while Hutchinson's melanotic freckles can be a sign of increased risk for developing melanoma, not all such lesions will become cancerous. However, any changes in size, shape, or color of these lesions should be evaluated by a healthcare professional as soon as possible.
Hyperpigmentation is a medical term that refers to the darkening of skin areas due to an increase in melanin, the pigment that provides color to our skin. This condition can affect people of all races and ethnicities, but it's more noticeable in those with lighter skin tones.
Hyperpigmentation can be caused by various factors, including excessive sun exposure, hormonal changes (such as during pregnancy), inflammation, certain medications, and underlying medical conditions like Addison's disease or hemochromatosis. It can also result from skin injuries, such as cuts, burns, or acne, which leave dark spots known as post-inflammatory hyperpigmentation.
There are several types of hyperpigmentation, including:
1. Melasma: This is a common form of hyperpigmentation that typically appears as symmetrical, blotchy patches on the face, particularly the forehead, cheeks, and upper lip. It's often triggered by hormonal changes, such as those experienced during pregnancy or while taking birth control pills.
2. Solar lentigos (age spots or liver spots): These are small, darkened areas of skin that appear due to prolonged sun exposure over time. They typically occur on the face, hands, arms, and decolletage.
3. Post-inflammatory hyperpigmentation: This type of hyperpigmentation occurs when an injury or inflammation heals, leaving behind a darkened area of skin. It's more common in people with darker skin tones.
Treatment for hyperpigmentation depends on the underlying cause and may include topical creams, chemical peels, laser therapy, or microdermabrasion. Preventing further sun damage is crucial to managing hyperpigmentation, so wearing sunscreen with a high SPF and protective clothing is recommended.
LEOPARD syndrome is a rare genetic disorder that is characterized by multiple lentigines (freckle-like spots), electrocardiographic abnormalities, ocular hypertelorism (wide-set eyes), pulmonic stenosis (narrowing of the pulmonary valve opening), abnormal genitalia, retardation of growth, and deafness. It is caused by mutations in the PTPN11 gene, which provides instructions for making a protein called SHP-2. This protein plays important roles in signaling pathways that control various cellular functions, such as cell growth and division. The signs and symptoms of LEOPARD syndrome can vary widely among affected individuals, even among members of the same family. Treatment is typically focused on managing the specific features of the condition in each individual.
Facial neoplasms refer to abnormal growths or tumors that develop in the tissues of the face. These growths can be benign (non-cancerous) or malignant (cancerous). Facial neoplasms can occur in any of the facial structures, including the skin, muscles, bones, nerves, and glands.
Benign facial neoplasms are typically slow-growing and do not spread to other parts of the body. Examples include papillomas, hemangiomas, and neurofibromas. While these tumors are usually harmless, they can cause cosmetic concerns or interfere with normal facial function.
Malignant facial neoplasms, on the other hand, can be aggressive and invasive. They can spread to other parts of the face, as well as to distant sites in the body. Common types of malignant facial neoplasms include basal cell carcinoma, squamous cell carcinoma, and melanoma.
Treatment for facial neoplasms depends on several factors, including the type, size, location, and stage of the tumor. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. It is important to seek medical attention promptly if you notice any unusual growths or changes in the skin or tissues of your face.
Melanosis is a general term that refers to an increased deposit of melanin, the pigment responsible for coloring our skin, in the skin or other organs. It can occur in response to various factors such as sun exposure, aging, or certain medical conditions. There are several types of melanosis, including:
1. Epidermal melanosis: This type of melanosis is characterized by an increase in melanin within the epidermis, the outermost layer of the skin. It can result from sun exposure, hormonal changes, or inflammation.
2. Dermal melanosis: In this type of melanosis, there is an accumulation of melanin within the dermis, the middle layer of the skin. It can be caused by various conditions such as nevus of Ota, nevus of Ito, or melanoma metastasis.
3. Mucosal melanosis: This type of melanosis involves an increase in melanin within the mucous membranes, such as those lining the mouth, nose, and genitals. It can be a sign of systemic disorders like Addison's disease or Peutz-Jeghers syndrome.
4. Lentigo simplex: Also known as simple lentigines, these are small, benign spots that appear on sun-exposed skin. They result from an increase in melanocytes, the cells responsible for producing melanin.
5. Labial melanotic macule: This is a pigmented lesion found on the lips, typically the lower lip. It is more common in darker-skinned individuals and is usually benign but should be monitored for changes that may indicate malignancy.
6. Ocular melanosis: An increase in melanin within the eye can lead to various conditions such as ocular melanocytosis, oculodermal melanocytosis, or choroidal melanoma.
It is important to note that while some forms of melanosis are benign and harmless, others may indicate an underlying medical condition or even malignancy. Therefore, any new or changing pigmented lesions should be evaluated by a healthcare professional.
Skin neoplasms refer to abnormal growths or tumors in the skin that can be benign (non-cancerous) or malignant (cancerous). They result from uncontrolled multiplication of skin cells, which can form various types of lesions. These growths may appear as lumps, bumps, sores, patches, or discolored areas on the skin.
Benign skin neoplasms include conditions such as moles, warts, and seborrheic keratoses, while malignant skin neoplasms are primarily classified into melanoma, squamous cell carcinoma, and basal cell carcinoma. These three types of cancerous skin growths are collectively known as non-melanoma skin cancers (NMSCs). Melanoma is the most aggressive and dangerous form of skin cancer, while NMSCs tend to be less invasive but more common.
It's essential to monitor any changes in existing skin lesions or the appearance of new growths and consult a healthcare professional for proper evaluation and treatment if needed.
Café-au-lait spots are light to dark brown, flat patches on the skin that are benign and usually harmless. The term "café-au-lait" means "coffee with milk," which describes the color of these spots. They can vary in size from a few millimeters to several centimeters in diameter and can appear anywhere on the body, although they are most commonly found on the trunk and buttocks.
While café-au-lait spots are common and can occur in up to 20% of the general population, having multiple (more than six) such spots, especially if they are large or present at birth, may be a sign of an underlying medical condition, such as neurofibromatosis type 1 (NF1), a genetic disorder that affects the growth and development of nerve tissue.
Therefore, it is essential to monitor café-au-lait spots and report any changes or concerns to a healthcare provider.
A nevus, also known as a mole, is a benign growth or mark on the skin that is usually brown or black. It can be raised or flat and can appear anywhere on the body. Nevi are made up of cells called melanocytes, which produce the pigment melanin. Most nevi develop in childhood or adolescence, but they can also appear later in life. Some people have many nevi, while others have few or none.
There are several types of nevi, including:
* Common nevi: These are the most common type of mole and are usually small, round, and brown or black. They can be flat or raised and can appear anywhere on the body.
* Atypical nevi: These moles are larger than common nevi and have irregular borders and color. They may be flat or raised and can appear anywhere on the body, but are most commonly found on the trunk and extremities. Atypical nevi are more likely to develop into melanoma, a type of skin cancer, than common nevi.
* Congenital nevi: These moles are present at birth and can vary in size from small to large. They are more likely to develop into melanoma than moles that develop later in life.
* Spitz nevi: These are rare, benign growths that typically appear in children and adolescents. They are usually pink or red and dome-shaped.
It is important to monitor nevi for changes in size, shape, color, and texture, as these can be signs of melanoma. If you notice any changes in a mole, or if you have a new mole that is unusual or bleeding, it is important to see a healthcare provider for further evaluation.
Palatal neoplasms refer to abnormal growths or tumors that occur on the palate, which is the roof of the mouth. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slower growing and less likely to spread, while malignant neoplasms are more aggressive and can invade nearby tissues and organs.
Palatal neoplasms can have various causes, including genetic factors, environmental exposures, and viral infections. They may present with symptoms such as mouth pain, difficulty swallowing, swelling or lumps in the mouth, bleeding, or numbness in the mouth or face.
The diagnosis of palatal neoplasms typically involves a thorough clinical examination, imaging studies, and sometimes biopsy to determine the type and extent of the growth. Treatment options depend on the type, size, location, and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. Regular follow-up care is essential to monitor for recurrence or spread of the neoplasm.
Hypopigmentation is a medical term that refers to a condition where there is a decrease in the amount of pigment (melanin) in the skin, resulting in lighter patches or spots on the skin. This can occur due to various reasons such as skin injuries, certain skin disorders like vitiligo, fungal infections, burns, or as a side effect of some medical treatments like chemotherapy or radiation therapy. It is different from albinism, which is a genetic condition where the body is unable to produce melanin at all.
Noonan Syndrome is a genetic disorder that affects various parts of the body and is characterized by distinctive facial features, short stature, heart defects, and developmental delays. It is caused by mutations in genes responsible for regulating cell growth and division. The syndrome is often identified at birth or in early childhood due to its physical manifestations, which may include widely spaced eyes, low-set ears, a short neck, a broad or webbed neck, chest deformities, and pulmonary valve stenosis. Noonan Syndrome affects both sexes and all races equally, with an estimated prevalence of 1 in 1,000 to 1 in 2,500 live births.
Dermoscopy, also known as dermatoscopy or epiluminescence microscopy, is a non-invasive diagnostic technique used in dermatology to evaluate skin lesions, such as moles and pigmented skin tumors. This method involves the use of a handheld device called a dermoscope, which consists of a magnifying lens, a light source, and a transparent plate or immersion fluid that allows for better visualization of the skin's surface structures.
Dermoscopy enables dermatologists to examine the pigmented patterns, vascular structures, and other morphological features hidden beneath the skin's surface that are not visible to the naked eye. By observing these details, dermatologists can improve their ability to differentiate between benign and malignant lesions, leading to more accurate diagnoses and appropriate treatment decisions.
The primary uses of dermoscopy include:
1. Early detection and diagnosis of melanoma and other skin cancers, such as basal cell carcinoma and squamous cell carcinoma.
2. Monitoring the evolution of suspicious moles or lesions over time.
3. Assisting in the identification of various benign skin growths, like seborrheic keratoses, dermatofibromas, and nevi (moles).
4. Improving the diagnostic accuracy for infectious skin conditions, inflammatory processes, and other dermatological disorders.
Overall, dermoscopy is a valuable tool in the field of dermatology that enhances the clinician's ability to diagnose and manage various skin conditions accurately and effectively.
A nevus pigmentosus, also known as a pigmented mole or melanocytic nevus, is a benign proliferation of melanocytes, the pigment-producing cells in the skin. These lesions typically appear as well-circumscribed, brown to black macules or papules. They can vary in size and shape and may be flat or raised. Most nevi are harmless and do not require treatment; however, some may undergo malignant transformation into melanoma, a potentially life-threatening skin cancer. Regular self-skin examinations and professional skin checks are recommended to monitor for changes in nevi that may indicate malignancy.
Skin pigmentation is the coloration of the skin that is primarily determined by two types of melanin pigments, eumelanin and pheomelanin. These pigments are produced by melanocytes, which are specialized cells located in the epidermis. Eumelanin is responsible for brown or black coloration, while pheomelanin produces a red or yellow hue.
The amount and distribution of melanin in the skin can vary depending on genetic factors, age, sun exposure, and various other influences. Increased production of melanin in response to UV radiation from the sun helps protect the skin from damage, leading to darkening or tanning of the skin. However, excessive sun exposure can also cause irregular pigmentation, such as sunspots or freckles.
Abnormalities in skin pigmentation can result from various medical conditions, including albinism (lack of melanin production), vitiligo (loss of melanocytes leading to white patches), and melasma (excessive pigmentation often caused by hormonal changes). These conditions may require medical treatment to manage or improve the pigmentation issues.
Melanoma is defined as a type of cancer that develops from the pigment-containing cells known as melanocytes. It typically occurs in the skin but can rarely occur in other parts of the body, including the eyes and internal organs. Melanoma is characterized by the uncontrolled growth and multiplication of melanocytes, which can form malignant tumors that invade and destroy surrounding tissue.
Melanoma is often caused by exposure to ultraviolet (UV) radiation from the sun or tanning beds, but it can also occur in areas of the body not exposed to the sun. It is more likely to develop in people with fair skin, light hair, and blue or green eyes, but it can affect anyone, regardless of their skin type.
Melanoma can be treated effectively if detected early, but if left untreated, it can spread to other parts of the body and become life-threatening. Treatment options for melanoma include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, depending on the stage and location of the cancer. Regular skin examinations and self-checks are recommended to detect any changes or abnormalities in moles or other pigmented lesions that may indicate melanoma.
I'm sorry for any confusion, but "sunlight" is not a term with a specific medical definition. However, sunlight does have various implications in the field of medicine. It is the light that comes from the sun, which is a star at the center of our solar system. Sunlight is essential for the production of vitamin D in humans, and it can also have effects on mood and sleep patterns due to its influence on circadian rhythms.
In a medical context, sunlight is often discussed in relation to its potential health benefits and risks. For instance, moderate sun exposure can help increase vitamin D levels, which are important for bone health, immune function, and other bodily processes. However, excessive sun exposure can lead to harmful effects, such as sunburn, premature skin aging, and an increased risk of skin cancer.
It's essential to balance the benefits and risks of sunlight exposure by practicing safe sun habits, such as wearing protective clothing, using a broad-spectrum sunscreen with an SPF of at least 30, seeking shade during peak sunlight hours, and avoiding intentional tanning.
Lentigo
Lentigo pipus
Lentigo lentiginosus
Lentigo (gastropod)
Lentigo maligna
Lentigo simplex
Ink spot lentigo
Lentigo maligna melanoma
PUVA lentigines
Mucosal lentigines
Noonan syndrome with multiple lentigines
June K. Robinson
Centrofacial lentiginosis
Nevus
Liver spot
Actinic keratosis
Melanoma
Blue nevus
Generalized lentiginosis
Nevus spilus
Partial unilateral lentiginosis
PUVA therapy
Conch
Dermatoscopy
Seborrheic keratosis
Photoaging
Carney complex
TAN syndrome
Paul Estermann
PTPN7
Lentigo - Wikipedia
Lentigo Differential Diagnoses
Lentigo Differential Diagnoses
Lentigo - solar on the back: MedlinePlus Medical Encyclopedia Image
Noonan syndrome with multiple lentigines: MedlinePlus Medical Encyclopedia
Noonan Syndrome with Multiple Lentigines - PubMed
Solar Lentigo (For Professionals) « Globale Dermatologie
Familial cases of atypical clinical features genetically diagnosed as LEOPARD syndrome (multiple lentigines syndrome) - PubMed
Low recurrence of lentigo maligna with off-label neoadjuvant imiquimod use
What are the most effective treatment/management interventions to improve outcomes in patients with lentigo maligna? - Cancer...
In vivo reflectance confocal microscopy can detect the invasive component of lentigo maligna melanoma: Prospective analysis and...
Noonan Syndrome with Multiple Lentigines - GeneReviews® - NCBI Bookshelf
Solar lentigo - dermoscopedia
Hydroquinone: Uses, safety, risks, and more
Anagrams of lentigo - Anagram Solver|Crossword.live
Lentigo maligna - Image | Evidence-Based Medicine Guidelines
Unscramble lentigo | Words unscrambled from letters lentigo | Scrabble Word lentigo | Words Made with the Letters lentigo
Lentigo maligna melanoma (Concept Id: C2739810) - MedGen - NCBI
lentigo - ENTERPRISEIG - The simplest way of personal development
Golden Puppies 7/7/2008 'Time Litter' - Lentigo Kennels
Lentigo Melanoma (ICD-10: С43) - Skin symptom checker app
These highlights do not include all the information needed to use AVAGE Cream safely and effectively. See full prescribing...
Lentigo/Lentigines | Dermatologist In West Palm Beach, FL | Integrated Dermatology
Hydrochlorothiazide Tied to Increased Melanoma Risk | MedPage Today
How Genes Influence Your Risk for Lentigines? - Xcode Life
Why Do We Get Freckles? | Advice | NIVEA
V znam slova lentigo - slovn k cudz ch slov - m jslovn k.sk
Effectiveness of 5% Topical Imiquimod for Lentigo Maligna Treatment<...
Estutio de Tratamiento de Lentigos Acto II - VoltaicPlasma - Areton LTD
Spectra Laser for Freckles and Solar Lentigines - Skin 'n Smiles
Maligna melanoma9
- Lentigo maligna melanoma is a subtype of melanoma that develops when a lentigo maligna (a subtype of melanoma in situ) enters vertical growth phase and invades into the dermis. (logicalimages.com)
- Lentigo maligna melanoma is associated with nonmelanoma skin cancers, light skin, Werner syndrome , oculocutaneous albinism , and xeroderma pigmentosa . (logicalimages.com)
- lentigo maligna melanoma in situ. (cyberderm.net)
- Lesions slowly extending and finally developing into a lentigo maligna melanoma. (cyberderm.net)
- Lentigo maligna melanoma and metastasis. (cyberderm.net)
- lentigo maligna melanoma pictures - this is an unpleasant disease. (diseaeseshows.com)
- The photos of lentigo maligna melanoma pictures below are not recommended for people with a weak psyche! (diseaeseshows.com)
- For many of us, especially in Australia, and even more so in the most sun-damaged parts of Australia, the diagnosis of lentigo maligna melanoma is very challenging. (healthcert.com)
- When invades the dermis, it becomes lentigo maligna melanoma and the prognostic features are identical to all other melanomas according to size and level of invasion. (amtsibiu.ro)
Freckles12
- Freckles will increase in number and darkness with sunlight exposure, whereas lentigines will stay stable in their color regardless of sunlight exposure. (wikipedia.org)
- Unlike freckles, the appearance of lentigines has nothing to do with sun exposure. (medlineplus.gov)
- Are They Lentigines or Freckles? (halecosmeceuticals.com)
- While freckles are common, another popular hyperpigmentation is a lentigines a large patch of pigmentation that resembles a birth mark or a large freckle. (halecosmeceuticals.com)
- While freckles and lentigines may look similar in appearance, they are actually quite different. (halecosmeceuticals.com)
- Both lentigines and freckles are caused by melanocytes. (halecosmeceuticals.com)
- But, here's something we do know both freckles and lentigines can worsen with increased exposure to sunlight. (halecosmeceuticals.com)
- If you've already had your time in the sun and are dissatisfied with the appearance of freckles and lentigines on your skin, there is hope. (halecosmeceuticals.com)
- The spots are similar in appearance to freckles, but lentigo solaris retains its color and number of spots even if the affected patient decreases sun exposure. (firstderm.com)
- If freckles or solar lentigines bother you, dermatologists can suggest treatments like chemical peels, freezing with liquid nitrogen, laser therapy , or lightening creams. (maxternmedia.com)
- Whether it's freckles, solar lentigines, or any other skin quirk, taking care of your skin ensures you'll shine your brightest. (maxternmedia.com)
- This article aims to provide a comprehensive understanding of common skin conditions in India, including moles, skin tags, freckles, lentigo, and seborrheic keratosis. (cims.org)
Melanoma in situ1
- Although Y2K never amounted to much, a solitary case report that year changed the dynamic in treating a vexing problem - melanoma in situ of the lentigo maligna (LM) subtype. (aad.org)
Simplex7
- Conditions characterized by lentigines include: Lentigo simplex Solar lentigo (Liver spots) PUVA lentigines Ink spot lentigo LEOPARD syndrome Mucosal lentigines Multiple lentigines syndrome Moynahan syndrome Generalized lentiginosis Centrofacial lentiginosis Carney complex Inherited patterned lentiginosis in black persons Partial unilateral lentiginosis Peutz-Jeghers syndrome Lentigo maligna Lentigo maligna melanoma Acral lentiginous melanoma Lentigines are distinguished from freckles (ephelis) based on the proliferation of melanocytes. (wikipedia.org)
- [ 8 ] Extensive lentigo simplex, linear epidermolytic nevus, and epidermolytic nevus comedonicus were linked with a somatic mutation in KRT10 . (medscape.com)
- The cause of lentigo simplex is unknown. (medscape.com)
- Lentigo simplex is a common benign, hyperpigmented macule located anywhere on the body. (logicalimages.com)
- Lentigo simplex may evolve into junctional nevi but are not thought to evolve into melanoma. (logicalimages.com)
- Lentigo simplex may occur as a single or as multiple lesions. (logicalimages.com)
- Lentigo simplex is the most common form of lentigo, but its frequency has yet to be determined. (medscape.com)
Solar lentigos3
- The concept of "unstable solar lentigos" evident as irregularly pigmented macules on the background of chronic sun damage has been considered alongside the idea that they may have malignant potential. (medscape.com)
- At least 4 solar lentigos at least 4 mm in diameter present on each dorsal hand. (who.int)
- Any previous treatment for solar lentigos on the dorsal hands. (who.int)
LEOPARD4
- Some lentigines have associated systemic manifestations that accompany the skin lesions, such as the LEOPARD syndrome . (medscape.com)
- Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome) is a condition that affects many areas of the body. (medlineplus.gov)
- Multiple lentigines on the face of a child with LEOPARD syndrome. (medscape.com)
- LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare autosomal dominant disorder most often caused by missense mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP2. (medscape.com)
Lesions6
- The distinction of a lentigo from other melanocytic lesions (eg, melanocytic nevi , melanoma ) and its role as a marker for ultraviolet damage and systemic syndromes is of major significance. (medscape.com)
- Some lentigines have associated systemic manifestations that accompany the skin lesions (see Physical Examination ). (medscape.com)
- [ 5 ] Depending on the type of lentigo present, a solitary lesion or multiple lesions can occur anywhere on the body. (medscape.com)
- Doctors who deal with head and neck surgery often are the ones to first diagnose and potentially treat a variety of facial lesions-and they are more and more often finding themselves dealing with lentigo maligna. (enttoday.org)
- Are these lesions actinic keratosis, solar lentigo, of lentigo maligna? (healthcert.com)
- It can vary in size and shape and can occur as a singular lesion or as multiple lesions (lentigines). (thomasjhoffmann.com)
Regressing seborrheic keratosis1
- Dermoscopic evaluation of a few lichenoid regressing solar lentigines showed a pattern similar to that of lichenoid regressing seborrheic keratosis. (medscape.com)
Benign3
- Lentigines by themselves are benign, however one might desire the removal or treatment of some of them for cosmetic purposes. (wikipedia.org)
- Lentigines are benign by nature. (medscape.com)
- Lentigo is a benign skin growth that resembles a freckle. (thomasjhoffmann.com)
Hyperpigmentation2
- Other rare disorders associated with multiple lentigines include generalized lentigines, arterial dissection with lentiginosis, Laugier-Hunziker syndrome , Cantú (hyperkeratosis-hyperpigmentation) syndrome, Cowden disease , centrofacial lentiginosis, and Bannayan-Riley-Ruvalcaba syndrome . (logicalimages.com)
- One sign of hyperpigmentation is solar lentigines or age spots, which manifest as darker patches on the skin. (novology.com)
Exposure8
- Long-term exposure to ultraviolet radiation and pollution as one ages may induce the common solar lentigo. (medscape.com)
- FGFR3 mutations were detected in 5 (17%) of 30 solar lentigines, and PIK3CA mutations were detected in 2 (7%) of 28 solar lentigines, suggesting that FGFR3 and PIK3CA mutations are involved in their pathogenesis and further substantiating previous speculations that ultraviolet (UV) exposure may be a causative factor for FGFR3 and PIK3CA mutations in human skin. (medscape.com)
- Solar lentigo and ink-spot lentigo are associated with sun exposure in fair-skinned people. (medscape.com)
- These lentigines generally occur early in life (may be present at birth) and are not associated with sun exposure. (logicalimages.com)
- To prevent lentigo solaris, wear sunscreen and avoid over-exposure to the sun. (firstderm.com)
- Lentigo: Lentigo is primarily caused by sun exposure and UV radiation. (cims.org)
- Lentigo: Lentigo is more common in individuals with fair skin and a history of excessive sun exposure. (cims.org)
- Solar lentigines or sunspots are the results of exposure to UV rays. (cosmo.ph)
Freckle1
- It starts as a Hutchinson's freckle, or lentigo maligna, which looks like a stain on the skin. (medicalnewstoday.com)
Noonan12
- As the condition name suggests, Noonan syndrome with multiple lentigines is very similar to a condition called Noonan syndrome, and it can be difficult to tell the two disorders apart in early childhood. (medlineplus.gov)
- Not all individuals with Noonan syndrome with multiple lentigines have all the characteristic features of this condition. (medlineplus.gov)
- The lentigines seen in Noonan syndrome with multiple lentigines typically first appear in mid-childhood, mostly on the face, neck, and upper body. (medlineplus.gov)
- Up to 20 percent of people with Noonan syndrome with multiple lentigines who have heart problems have a narrowing of the artery from the heart to the lungs (pulmonary stenosis). (medlineplus.gov)
- People with Noonan syndrome with multiple lentigines can have a distinctive facial appearance. (medlineplus.gov)
- At birth, people with Noonan syndrome with multiple lentigines are typically of normal weight and height, but in some, growth slows over time. (medlineplus.gov)
- This slow growth results in affected individuals being shorter than average, although less than half of people with Noonan syndrome with multiple lentigines have significantly short stature. (medlineplus.gov)
- Noonan syndrome with multiple lentigines is one of a group of related conditions collectively known as RASopathies. (medlineplus.gov)
- In addition to Noonan syndrome with multiple lentigines, the RASopathies include Noonan syndrome, cardiofaciocutaneous syndrome , Costello syndrome , neurofibromatosis type 1 , and Legius syndrome . (medlineplus.gov)
- Variants (also known as mutations) in one of several genes can cause Noonan syndrome with multiple lentigines. (medlineplus.gov)
- The remaining individuals with Noonan syndrome with multiple lentigines do not have an identified mutation in any of these four genes. (medlineplus.gov)
- Noonan syndrome with multiple lentigines (NSML) is a rare inherited disorder. (nih.gov)
Nevi1
- Lentigines, nevi, and melanomas. (stlukes-stl.com)
PUVA1
- Psoralen plus UVA (PUVA) lentigines are noted in almost one half of individuals with psoriasis who receive PUVA therapy for at least 5 years. (medscape.com)
Atopic dermatitis1
- Case reports have described simple lentigines developing in children after use of topical tacrolimus for atopic dermatitis. (medscape.com)
Acral1
- The 185 melanoma biopsies (69 superficial spreading, 45 nodular, 16 lentigo-maligna, 5 acral, and 50 malignant melanomas without further subtyping) were collected from 179 patients from Germany (70 females, 109 males) during 2002-2017. (cdc.gov)
Diagnosis3
- Prof David Wilkinson reviews a powerful summary consensus paper on the diagnosis, treatment and surveillance for lentigo maligna. (healthcert.com)
- So, this month's paper is especially useful and relevant: a really powerful summary consensus paper on the diagnosis, treatment and surveillance for lentigo maligna. (healthcert.com)
- Supplementary material for 'Perifollicular linear projections: A dermoscopic criterion for the diagnosis of lentigo maligna on the face. (mendeley.com)
Imiquimod3
- Ahmed and Berth Jones reported treating an 88-year old man with a large lentigo maligna of his scalp with imiquimod 5% cream. (aad.org)
- 5) Tio et al reviewed their experience of 57 patients with lentigo maligna who were treated with off-label topical imiquimod once daily for 12 weeks. (aad.org)
- Oklahoma City -- Topical application of the immune response modifier imiquimod appears to be an effective and reasonably well-tolerated treatment for lentigo maligna, according to research conducted by dermatologists from the University of Oklahoma Health Sciences Center, Oklahoma City. (dermatologytimes.com)
Syndrome1
- [ 1 ] Zeisler and Becker first described the syndrome in 1936 in a 24-year-old woman with progressive generalized lentigines, hypertelorism, pectus carinatum, and prognathism. (medscape.com)
Liver spots2
- Lentigo solaris, or liver spots, are brown pigmented spots on the skin caused by natural or artificial ultraviolet (UV) rays. (firstderm.com)
- Solar lentigines, frequently referred to as age spots or liver spots, are one of the most common types of lentigines. (thomasjhoffmann.com)
Sunspots1
- They form clusters that appear on the skin surface as small, dark, flat, or dome-shaped spots, which are often harmless sunspots called lentigo. (limamemorial.org)
Malignant1
- A healthcare provider can diagnose your condition with visual examination, but sometimes it is difficult to differentiate an irregular lentigo solaris from malignant melanoma . (firstderm.com)
Irregular1
- Lentigines found on mucous membranes can appear irregular with increased size, irregular borders, and heterogeneous pigmentation. (logicalimages.com)
Centrofacial1
- Inherited patterned lentiginosis - Individuals of African descent frequently have centrofacial lentigines that are autosomal-dominantly inherited. (logicalimages.com)
Proliferation of melanocytes1
- Lentigines, on the other hand, are caused by a proliferation of melanocytes that is localized and not dispersed. (halecosmeceuticals.com)
Multiple4
- A case-controlled study in France comparing 145 adults with multiple solar lentigines on the upper back and 145 matched control subjects found that multiple solar lentigines on the upper back and shoulders of adults may serve as clinical markers of past severe sunburn and may be used to identify a population at higher risk of developing cutaneous melanoma. (medscape.com)
- Occasionally, multiple lentigines are associated with rare genetic disorders. (logicalimages.com)
- [ 12 ] In one Bosnian family, five patients had the same recurrent mutation Y279C in the PTPN11 gene, but had different phenotypes and a variable expression of multiple lentigines. (medscape.com)
- [ 12 ] The father had multiple lentigines equally dispersed over his body as depicted below, whereas his son was devoid of lentigines on the left part of the thorax, back, and left arm. (medscape.com)
Fair-skinned1
- Solar lentigines are more abundant in fair-skinned whites than in dark-skinned individuals, in whom the disease is distinctly uncommon because they have a greater amount of natural pigment that provides some degree of photoprotection. (medscape.com)
Keratosis1
- Seborrheic keratosis and lentigo solaris were found to be increased on the driver side of the face in an evaluation of truck drivers in Turkey assessing the effects of UV light. (medscape.com)
Abnormalities1
- In patients in whom lentigines are associated with systemic abnormalities or complications, the prognosis may depend on the severity of the associated conditions. (medscape.com)
Commonly2
- We commonly know lentigines as sun spots or age spots. (halecosmeceuticals.com)
- Lentigines appear more commonly as the skin ages into middle and older age. (halecosmeceuticals.com)
Macule1
- A lentigo is a small, sharply circumscribed, pigmented macule surrounded by normal-appearing skin. (medscape.com)
Treatment1
- Treatment of solar lentigines. (firstderm.com)
Evolve1
- Lentigines may evolve slowly over years, or they may be eruptive and appear rather suddenly. (medscape.com)
Solaris3
- Therefore, individuals with lentigo solaris may be more at risk for skin cancer forms such as squamous cell carcinoma and basal cell carcinoma . (firstderm.com)
- Lentigo solaris is a flat, well-defined patch. (firstderm.com)
- Lentigo solaris does not require medical attention. (firstderm.com)