Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.
A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.
Demyelinating leukoencephalomyelitis of sheep caused by the VISNA-MAEDI VIRUS. It is similar to but not the same as SCRAPIE.
Chronic respiratory disease caused by the VISNA-MAEDI VIRUS. It was formerly believed to be identical with jaagsiekte (PULMONARY ADENOMATOSIS, OVINE) but is now recognized as a separate entity.
A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.
A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), that can cause chronic pneumonia (maedi), mastitis, arthritis, and encephalomyelitis (visna) in sheep. Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). Visna is a demyelinating leukoencephalomyelitis of sheep which is similar to but not the same as SCRAPIE.
Acquired defect of cellular immunity that occurs in cats infected with feline immunodeficiency virus (FIV) and in some cats infected with feline leukemia virus (FeLV).
A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in sheep and goats.
A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.
A species of LENTIVIRUS, subgenus equine lentiviruses (LENTIVIRUSES, EQUINE), causing acute and chronic infection in horses. It is transmitted mechanically by biting flies, mosquitoes, and midges, and iatrogenically through unsterilized equipment. Chronic infection often consists of acute episodes with remissions.
Viral disease of horses caused by the equine infectious anemia virus (EIAV; INFECTIOUS ANEMIA VIRUS, EQUINE). It is characterized by intermittent fever, weakness, and anemia. Chronic infection consists of acute episodes with remissions.
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.
Acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or MASON-PFIZER MONKEY VIRUS; (MPMV), or in monkeys infected with SIMIAN IMMUNODEFICIENCY VIRUS.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
A subgenus of LENTIVIRUS comprising viruses that produce immunodeficiencies in primates, including humans.
A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in cattle.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
A genus in the family FELIDAE comprising one species, Puma concolor. It is a large, long-tailed, feline of uniform color. The names puma, cougar, and mountain lion are used interchangeably for this species. There are more than 20 subspecies.
A genus of Old World monkeys found in Africa although some species have been introduced into the West Indies. This genus is composed of at least twenty species: C. AETHIOPS, C. ascanius, C. campbelli, C. cephus, C. denti, C. diana, C. dryas, C. erythrogaster, C. erythrotis, C. hamlyni, C. lhoesti, C. mitis, C. mona, C. neglectus, C. nictitans, C. petaurista, C. pogonias, C. preussi, C. salongo, and C. wolfi.
Large, chiefly nocturnal mammals of the cat family FELIDAE, species Panthera leo. They are found in Africa and southern Asia.
A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in cats.
Diseases of domestic and mountain sheep of the genus Ovis.
Diseases of the domestic or wild goat of the genus Capra.
A genus of the family Lemuridae consisting of five species: L. catta (ring-tailed lemur), L. fulvus, L. macaco (acoumba or black lemur), L. mongoz (mongoose lemur), and L. variegatus (white lemur). Most members of this genus occur in forested areas on Madagascar and the Comoro Islands.
The type species of LENTIVIRUS, subgenus bovine lentiviruses (LENTIVIRUSES, BOVINE), found in cattle and causing lymphadenopathy, LYMPHOCYTOSIS, central nervous system lesions, progressive weakness, and emaciation. It has immunological cross-reactivity with other lentiviruses including HIV.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

Vaccination with experimental feline immunodeficiency virus vaccines, based on autologous infected cells, elicits enhancement of homologous challenge infection. (1/306)

Cats were vaccinated with fixed autologous feline immunodeficiency virus (FIV)-infected cells in order to present viral proteins to the immune system of individual cats in an MHC-matched fashion. Upon vaccination, a humoral response against Gag was induced. Furthermore, virus-neutralizing antibodies were detected in a Crandell feline kidney cell-based neutralization assay, but not in a neutralization assay based on primary peripheral blood mononuclear cells. Despite the induction of these FIV-specific responses, vaccinated cats were not protected. Instead, accelerated virus replication was found, an observation similar to what previous experiments using other vaccine candidates have shown. Here, the results of the present study are discussed in the light of enhancement of lentivirus infections as a complicating factor in lentivirus vaccine development.  (+info)

Gene transfer to human pancreatic endocrine cells using viral vectors. (2/306)

We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors efficiently infected intact pancreatic islets and fetal islet-like cell clusters (ICCs) in suspension. When islets and ICCs were plated in monolayer culture, infection efficiency with all three viral vectors increased. Ad-GFP infected 90-95% of the cells, whereas infection with MLV-GFP and Lenti-GFP increased only slightly. Both exposure to hepatocyte growth factor/scatter factor (HGF/SF) and dispersion of the cells by removal from the culture dish and replating had substantial positive effects on the efficiency of infection with retroviral vectors. Studies of virus entry and cell replication revealed that cell dispersion and stimulation by HGF/SF may be acting through both mechanisms to increase the efficiency of retrovirus-mediated gene transfer. Although HGF/SF and cell dispersion increased the efficiency of infection with MLV-GFP, only rare cells with weak staining for insulin were infected, whereas approximately 25% of beta-cells were infected with Lenti-GFP. We conclude that adenovirus is the most potent vector for ex vivo overexpression of foreign genes in adult endocrine pancreatic cells and is the best vector for applications where high-level but transient expression is desired. Under the optimal conditions of cell dispersion plus HGF/SF, infection with MLV and lentiviral vectors is reasonably efficient and stable, but only lentiviral vectors efficiently infect pancreatic beta-cells.  (+info)

Goat milk epithelial cells are highly permissive to CAEV infection in vitro. (3/306)

The main route of small ruminant lentivirus dissemination is the ingestion of infected cells present in colostrum and milk from infected animals. However, whether only macrophages or other cell subtypes are involved in this transmission is unknown. We derived epithelial cell cultures, 100% cytokeratin positive, from milk of naturally infected and noninfected goats. One such culture, derived from a naturally infected goat, constitutively produced a high titer of virus in the absence of any cytopathic effect. The other cultures, negative for natural lentivirus infection, were tested for their susceptibility to infection with the CAEV-CO strain and a French field isolate CAEV-3112. We showed that milk epithelial cells are easily infected by either virus and produce viruses at titers as high as those obtained in permissive goat synovial membrane cells. The CAEV-CO strain replicated in milk epithelial cells in absence of any cytopathic effect, whereas the CAEV-3112 field isolate induced both cell fusion and cell lysis. Our results suggest that CAEV-infected milk epithelial cells of small ruminants may play an important role in virus transmission and pathogenesis.  (+info)

Seroprevalence of bovine immunodeficiency virus in dairy and beef cattle herds in Korea. (4/306)

Infection of bovine immunodeficiency virus (BIV), a lentivirus, is thought to sporadically occur throughout the world, but seroepidemiological surveys concerning the incidence of BIV are limited and have not been undertaken in Korea. A total of 266 sera from different twenty dairy (Holstein) and twenty-six Korean native beef (Hanwoo) farms of the south-western part of Korea was analyzed for the presence of anti-BIV antibodies by Western blotting. Thirty five percent and 33% of dairy and beef cattle, respectively, were BIV-seropositive. By nested polymerase chain reaction, it was confirmed that these seropositive cows had provirus in the peripheral blood mononuclear cells. To demonstrate the correlation with BIV and bovine leukemia virus (BLV) infection, these sera were also analyzed for anti-BLV antibodies by immunodiffusion test, resulting in high prevalence of BLV infection but relatively a few dual infections. We report herein the first serological detection of antibodies to BIV in Korea.  (+info)

Inducible nitric oxide synthase is expressed in joints of goats in the late stage of infection with caprine arthritis encephalitis virus. (5/306)

We have studied the expression of the inducible form of nitric oxide synthase (iNOS) in joints of goats infected with the caprine arthritis encephalitis virus (CAEV). Nitric oxide generated by iNOS is thought to play an important role in the pathogenesis of various types of arthritis, especially rheumatoid arthritis (RA) in humans. Surprisingly, iNOS immunoreactivity was found only in joints of long-term infected goats with severe clinical arthritis, whereas-despite the presence of high numbers of inflammatory cells in the synovial tissue-no iNOS immunoreactivity was detected in mildly arthritic and in short-term experimentally infected goats. Most iNOS-positive cells expressed neither MHC class II nor CD68, which suggests that they were fibroblast-like synoviocytes. In situ hybridization studies showed that there was no correlation between iNOS immunoreactivity and detectable virus expression in the joint. In addition, infection of macrophages in vitro-the major host cells of CAEV in vivo-did not lead to increased iNOS mRNA expression. In response to stimulation, similar levels of iNOS expression were observed in infected and in uninfected macrophages. These findings suggest that the expression of iNOS is a feature of late-stage chronic arthritis and is not involved in the development of the inflammatory lesions. Both the lack of co-localization of iNOS protein and viral transcripts in the joint and the finding that CAEV does not stimulate the expression of iNOS in vitro further suggest that iNOS is not directly induced by the virus or the anti-viral immune response in the joint, that it may well, however, be involved in tissue remodelling or scar formation.  (+info)

Interspecies transmission of feline immunodeficiency virus from the domestic cat to the Tsushima cat (Felis bengalensis euptilura) in the wild. (6/306)

Feline immunodeficiency virus (FIV) was isolated from a wild-caught Tsushima cat (Felis bengalensis euptilura), an endangered Japanese nondomestic subspecies of leopard cat (F. bengalensis). Phylogenetic analysis of the env gene sequences indicated that the FIV from the Tsushima cat belonged to a cluster of subtype D FIVs from domestic cats. FIVs from both the Tsushima cat and the domestic cat showed similar levels of replication and cytopathicity in lymphoid cell lines derived from these two species. The results indicated the occurrence of interspecies transmission of FIV from the domestic cat to the Tsushima cat in the wild.  (+info)

Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study. (7/306)

Although foamy viruses (Spumaviruses) have repeatedly been isolated from both healthy and diseased cats, cattle, and primates, the primary mode of transmission of those common viruses remains undefined. A database of the feline foamy virus (FeFV) and feline immunodeficiency virus (FIV) antibody status, age, and sex of 389 domestic cats presented to veterinarians was assembled. A similar database for 66 feral (wild) cats was also assembled. That FeFV antibody status reflects infection was validated by PCR. Both FeFV and FIV infection rates were found to gradually increase with age, and over 70% of cats older than 9 years were seropositive for FeFV. In domestic cats, the prevalence of FeFV infection was similar in both sexes. In feral cats, FeFV infection was more prevalent in female cats than in male cats. Although both FeFV and FIV have been reported to be transmitted by biting, the patterns of infection observed are more consistent with an interpretation that transmission of these two retroviruses is not the same. The prevalence of FIV infection is highest in nondesexed male cats, the animals most likely to display aggressive behavior. The gradual increase in the proportion of FeFV-infected animals is consistent with transmission of foamy viruses by intimate social contact between animals and less commonly by aggressive behavior.  (+info)

A new sensitive serological assay for detection of lentivirus infections in small ruminants. (8/306)

Lentivirus infections in small ruminants represent an economic problem affecting several European countries with important sheep-breeding industries. Programs for control and eradication of these infections are being initiated and require reliable screening assays. This communication describes the construction and evaluation of a new serological screening enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to maedi-visna virus (MVV) in sheep and to caprine arthritis encephalitis virus (CAEV) in goats. The solid phase is sensitized with a combination of the major core protein p25 of MVV produced in Escherichia coli and a peptide derived from the immunodominant region of the viral transmembrane protein gp46. The peptide carries an N-terminal biotin residue and is complexed with streptavidin prior to being coated. The new assay was evaluated with 2,336 sheep serum samples from different European countries with large differences in the levels of prevalence of MVV infections, and the results have been compared to those of the standard agar gel immunodiffusion test. Discrepant samples were analyzed by Western blotting with viral lysate, and most sera could be classified unambiguously. The estimated overall sensitivity of the new ELISA was 99.4% (95% confidence interval [CI], 98.4 to 99. 8%) and the specificity was 99.3% (95% CI, 98.7 to 99.6%). A limited set of goat sera (n = 212) was also analyzed, with similar results. These data indicate that the new assay is a reliable tool that can be used in control and eradication programs for small ruminant lentivirus infections.  (+info)

Lentivirus infections refer to the infectious disease caused by lentiviruses, a genus of retroviruses. These viruses are characterized by their ability to cause persistent and long-term infections, often leading to chronic diseases. They primarily target cells of the immune system, such as T-cells and macrophages, and can cause significant immunosuppression.

Lentiviruses have a slow replication cycle and can remain dormant in the host for extended periods. This makes them particularly effective at evading the host's immune response and can result in progressive damage to infected tissues over time.

One of the most well-known lentiviruses is the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). HIV infects and destroys CD4+ T-cells, leading to a weakened immune system and increased susceptibility to opportunistic infections.

Other examples of lentiviruses include simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV), and equine infectious anemia virus (EIAV). While these viruses primarily infect non-human animals, they are closely related to HIV and serve as important models for studying lentivirus infections and developing potential therapies.

A lentivirus is a type of slow-acting retrovirus that can cause chronic diseases and cancers. The term "lentivirus" comes from the Latin word "lentus," which means slow. Lentiviruses are characterized by their ability to establish a persistent infection, during which they continuously produce new viral particles.

Lentiviruses have a complex genome that includes several accessory genes, in addition to the typical gag, pol, and env genes found in all retroviruses. These accessory genes play important roles in regulating the virus's replication cycle and evading the host's immune response.

One of the most well-known lentiviruses is the human immunodeficiency virus (HIV), which causes AIDS. Other examples include the feline immunodeficiency virus (FIV) and the simian immunodeficiency virus (SIV). Lentiviruses have also been used as vectors for gene therapy, as they can efficiently introduce new genes into both dividing and non-dividing cells.

Visna is not a term that is commonly used in modern medical terminology. However, it is a disease that affects sheep and goats, caused by the Visna Maedi virus, which is a type of retrovirus. The name "Visna" means "wasting" in Icelandic, reflecting one of the symptoms of the disease.

In animals, Visna is a slowly progressive, degenerative disease that affects the central nervous system, leading to neurological symptoms such as weakness, tremors, and paralysis. It can also cause pneumonia and mastitis (inflammation of the mammary glands). The virus is transmitted through bodily fluids such as milk, saliva, and semen, and there is no cure for the disease once an animal becomes infected.

It's worth noting that Visna is not a human disease, although there are other retroviruses that can cause similar neurological symptoms in humans, such as HIV (Human Immunodeficiency Virus).

Progressive interstitial pneumonia of sheep, also known as ovine progressive pneumonic dyspnea (OPPD), is a contagious and fatal disease that affects the respiratory system of sheep. It is caused by the bacterium Mycoplasma ovipneumoniae.

The disease is characterized by inflammation and fibrosis of the interstitial tissue of the lungs, which leads to progressive difficulty in breathing, coughing, and weight loss. The infection can also spread to the air sacs (alveoli) of the lungs, causing pus-filled lesions and further compromising lung function.

OPPD is a chronic disease that can take several months to progress from initial infection to death. It is highly contagious and can be spread through direct contact with infected animals or contaminated equipment. The disease is most commonly seen in sheep that are under stress, such as those that have been transported or housed in close quarters.

Prevention and control measures for OPPD include good biosecurity practices, such as quarantine and testing of new animals before introducing them to a flock, as well as vaccination of susceptible animals. Treatment is generally not effective once clinical signs appear, and affected animals usually need to be euthanized to prevent further spread of the disease.

Feline Immunodeficiency Virus (FIV) is a lentivirus that primarily affects felines, including domestic cats and wild cats. It is the feline equivalent of Human Immunodeficiency Virus (HIV). The virus attacks the immune system, specifically the CD4+ T-cells, leading to a decline in the immune function over time.

This makes the infected cat more susceptible to various secondary infections and diseases. It is usually transmitted through bite wounds from infected cats during fighting or mating. Mother to offspring transmission can also occur, either in utero, during birth, or through nursing.

There is no cure for FIV, but antiretroviral therapy can help manage the disease and improve the quality of life for infected cats. It's important to note that while FIV-positive cats can live normal lives for many years, they should be kept indoors to prevent transmission to other cats and to protect them from opportunistic infections.

Visna-maedi virus (VMV) is an retrovirus that belongs to the genus Lentivirus, which is part of the family Retroviridae. This virus is the causative agent of a slowly progressive, fatal disease in sheep known as maedi-visna. The term "visna" refers to a inflammatory disease of the central nervous system (CNS) and "maedi" refers to a progressive interstitial pneumonia.

The Visna-Maedi virus is closely related to the human immunodeficiency virus (HIV), which causes AIDS, as well as to other lentiviruses that affect animals such as caprine arthritis encephalitis virus (CAEV) and equine infectious anemia virus (EIAV).

Visna-maedi virus primarily targets the immune system cells, specifically monocytes/macrophages, leading to a weakened immune response in infected animals. This makes them more susceptible to other infections and diseases. The virus is transmitted through the respiratory route and infection can occur through inhalation of infectious aerosols or by ingestion of contaminated milk or colostrum from infected ewes.

There is no effective treatment or vaccine available for Visna-maedi virus infection, and control measures are focused on identifying and isolating infected animals to prevent the spread of the disease within sheep flocks.

Feline Acquired Immunodeficiency Syndrome (FAIDS) is a progressive immune disorder in cats caused by infection with the feline immunodeficiency virus (FIV). The virus attacks and weakens the cat's immune system, making it difficult for the animal to fight off other infections and diseases.

The initial infection with FIV may cause symptoms such as fever, swollen lymph nodes, and loss of appetite. However, many cats do not show any signs of illness for years after the initial infection. As the immune system becomes weaker over time, the cat becomes more susceptible to various secondary infections, cancers, and other diseases. Common symptoms in advanced stages of FAIDS include weight loss, chronic or recurring infections (such as respiratory, skin, or gastrointestinal infections), dental disease, anemia, and neurological disorders.

FAIDS is most commonly spread through bite wounds from infected cats, as the virus is present in their saliva. It can also be transmitted through sexual contact or from mother to kitten during pregnancy or nursing. There is no cure for FAIDS, but antiretroviral therapy (ART) can help manage the infection and slow down its progression. Supportive care, such as proper nutrition, regular veterinary check-ups, and monitoring for secondary infections, is essential for maintaining the cat's quality of life.

It is important to note that FIV is species-specific and cannot be transmitted from cats to humans or other animals, except non-human primates.

Lentiviruses, ovine-caprine, refer to a subgroup of lentiviruses that primarily infect sheep and goats. These viruses are part of the Retroviridae family and cause slowly progressive diseases characterized by immunodeficiency and neurological disorders. The most well-known members of this group include:

1. Ovine progressive pneumonia virus (OPPV/Maedi Visna virus, MVV): This lentivirus primarily affects sheep, causing chronic interstitial pneumonia and progressive wasting. It can also lead to neurological symptoms such as tremors, ataxia, and paralysis in advanced stages.

2. Caprine arthritis-encephalitis virus (CAEV): This lentivirus primarily infects goats, causing chronic arthritis, pneumonia, and mastitis in adult animals. It can also lead to neurological symptoms such as encephalitis, particularly in young kids.

Both OPPV and CAEV are transmitted horizontally through close contact with infected animals, usually via the respiratory route, and vertically from infected ewes or does to their offspring in utero or through colostrum and milk consumption. These viruses have a worldwide distribution and can cause significant economic losses in sheep and goat farming industries due to decreased productivity, increased mortality, and restrictions on trade and movement of infected animals.

I apologize, but there is no medical definition for "Arthritis-Encephalitis Virus, Caprine." The term "Caprine" refers to something related to or derived from goats. Arthritis-Encephalitis Viruses (AEV) are a group of viruses that can affect various animal species and cause joint inflammation (arthritis) and brain inflammation (encephalitis). However, I couldn't find any specific virus named "Arthritis-Encephalitis Virus, Caprine" in the medical literature.

There are several viruses that can affect goats and cause arthritis and encephalitis, such as CAEV (Caprine Arthritis-Encephalitis Virus) or PPRV (Peste des Petits Ruminants Virus). If you have any specific concerns about a particular virus affecting goats, please provide more context so I can give you a more accurate and helpful response.

Equine Infectious Anemia (EIA) is a viral disease that affects horses and other equine animals. The causative agent of this disease is the Equine Infectious Anemia Virus (EIAV), which belongs to the family Retroviridae and genus Lentivirus. This virus is primarily transmitted through the transfer of infected blood, most commonly through biting insects such as horseflies and deerflies.

The EIAV attacks the immune system of the infected animal, causing a variety of symptoms including fever, weakness, weight loss, anemia, and edema. The virus has a unique ability to integrate its genetic material into the host's DNA, which can lead to a lifelong infection. Some animals may become chronic carriers of the virus, showing no signs of disease but remaining infectious to others.

There is currently no cure for EIA, and infected animals must be isolated to prevent the spread of the disease. Vaccines are available in some countries, but they do not provide complete protection against infection and may only help reduce the severity of the disease. Regular testing and monitoring of equine populations are essential to control the spread of this virus.

Equine infectious anemia (EIA) is a viral disease that affects horses and other equine animals. It is caused by the Equine Infectious Anemia Virus (EIAV), which is transmitted through the bloodstream of infected animals, often through biting insects such as horseflies and deerflies.

The symptoms of EIA can vary widely, but often include fever, weakness, weight loss, anemia, and edema. In severe cases, the disease can cause death. There is no cure for EIA, and infected animals must be isolated to prevent the spread of the virus.

EIA is diagnosed through blood tests that detect the presence of antibodies to the virus. Horses that test positive for EIA are typically euthanized or permanently quarantined. Prevention measures include testing horses before they are bought, sold, or moved, as well as controlling insect populations and using insect repellents. Vaccines are not available for EIA in most countries.

"Cat" is a common name that refers to various species of small carnivorous mammals that belong to the family Felidae. The domestic cat, also known as Felis catus or Felis silvestris catus, is a popular pet and companion animal. It is a subspecies of the wildcat, which is found in Europe, Africa, and Asia.

Domestic cats are often kept as pets because of their companionship, playful behavior, and ability to hunt vermin. They are also valued for their ability to provide emotional support and therapy to people. Cats are obligate carnivores, which means that they require a diet that consists mainly of meat to meet their nutritional needs.

Cats are known for their agility, sharp senses, and predatory instincts. They have retractable claws, which they use for hunting and self-defense. Cats also have a keen sense of smell, hearing, and vision, which allow them to detect prey and navigate their environment.

In medical terms, cats can be hosts to various parasites and diseases that can affect humans and other animals. Some common feline diseases include rabies, feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), and toxoplasmosis. It is important for cat owners to keep their pets healthy and up-to-date on vaccinations and preventative treatments to protect both the cats and their human companions.

I'm sorry for any confusion, but "goats" is not a term commonly used in medical definitions. It is a common noun referring to the domesticated animal species Capra aegagrus hircus. If you have any questions about a specific medical condition or term, please provide that and I would be happy to help.

Simian Immunodeficiency Virus (SIV) is a retrovirus that primarily infects African non-human primates and is the direct ancestor of Human Immunodeficiency Virus type 2 (HIV-2). It is similar to HIV in its structure, replication strategy, and ability to cause an immunodeficiency disease in its host. SIV infection in its natural hosts is typically asymptomatic and non-lethal, but it can cause AIDS-like symptoms in other primate species. Research on SIV in its natural hosts has provided valuable insights into the mechanisms of HIV pathogenesis and potential strategies for prevention and treatment of AIDS.

Simian Acquired Immunodeficiency Syndrome (SAIDS) is not recognized as a medical condition in humans. However, it is a disease that affects non-human primates like African green monkeys and sooty mangabeys. SAIDS is caused by the Simian Immunodeficiency Virus (SIV), which is similar to the Human Immunodeficiency Virus (HIV) that leads to Acquired Immunodeficiency Syndrome (AIDS) in humans.

In non-human primates, SIV infection can lead to a severe immunodeficiency state, characterized by the destruction of CD4+ T cells and impaired immune function, making the host susceptible to various opportunistic infections and cancers. However, it is important to note that most non-human primates infected with SIV do not develop SAIDS spontaneously, unlike humans who acquire HIV infection.

In summary, Simian Acquired Immunodeficiency Syndrome (SAIDS) is a disease affecting non-human primates due to Simian Immunodeficiency Virus (SIV) infection, characterized by immunodeficiency and susceptibility to opportunistic infections and cancers. It should not be confused with Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome (HIV/AIDS) in humans.

I'm sorry for any confusion, but "horses" is not a medical term. It is the common name given to the species *Equus ferus caballus*, which are large domesticated mammals used for transportation, work, and recreation. If you have any questions about horses or a related topic that you would like a medical perspective on, please let me know and I'd be happy to help!

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

Antibodies, viral are proteins produced by the immune system in response to an infection with a virus. These antibodies are capable of recognizing and binding to specific antigens on the surface of the virus, which helps to neutralize or destroy the virus and prevent its replication. Once produced, these antibodies can provide immunity against future infections with the same virus.

Viral antibodies are typically composed of four polypeptide chains - two heavy chains and two light chains - that are held together by disulfide bonds. The binding site for the antigen is located at the tip of the Y-shaped structure, formed by the variable regions of the heavy and light chains.

There are five classes of antibodies in humans: IgA, IgD, IgE, IgG, and IgM. Each class has a different function and is distributed differently throughout the body. For example, IgG is the most common type of antibody found in the bloodstream and provides long-term immunity against viruses, while IgA is found primarily in mucous membranes and helps to protect against respiratory and gastrointestinal infections.

In addition to their role in the immune response, viral antibodies can also be used as diagnostic tools to detect the presence of a specific virus in a patient's blood or other bodily fluids.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

HIV-1 (Human Immunodeficiency Virus type 1) is a species of the retrovirus genus that causes acquired immunodeficiency syndrome (AIDS). It is primarily transmitted through sexual contact, exposure to infected blood or blood products, and from mother to child during pregnancy, childbirth, or breastfeeding. HIV-1 infects vital cells in the human immune system, such as CD4+ T cells, macrophages, and dendritic cells, leading to a decline in their numbers and weakening of the immune response over time. This results in the individual becoming susceptible to various opportunistic infections and cancers that ultimately cause death if left untreated. HIV-1 is the most prevalent form of HIV worldwide and has been identified as the causative agent of the global AIDS pandemic.

Lentiviruses are a genus of retroviruses that cause chronic diseases with long incubation periods. Primate lentiviruses specifically refer to those that primarily infect primates, including humans. There are four main types of primate lentiviruses: human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), simian immunodeficiency virus (SIV), and puma (or lion) lentivirus (PLV).

HIV-1 is the primary cause of acquired immunodeficiency syndrome (AIDS) in humans, while HIV-2 is less virulent and prevalent. SIV infects various species of non-human primates, causing an AIDS-like disease. PLV infects wild pumas and domestic cats, causing a slow, progressive immune deficiency.

Primate lentiviruses have complex life cycles involving both DNA and RNA stages. They can integrate their genetic material into the host cell's genome, leading to persistent infection and potential oncogenic effects. These viruses primarily target cells of the immune system, such as CD4+ T-cells and macrophages, ultimately leading to immunodeficiency and increased susceptibility to opportunistic infections.

Lentiviruses, Bovine, refer to a genus of retroviruses that cause a slow, chronic infection in cattle. These viruses are characterized by their ability to infect non-dividing cells and establish a persistent infection. The bovine lentiviruses include the Maedi-Visna virus (MVV) and the Bovine Immunodeficiency Virus (BIV).

MVV primarily affects the respiratory and central nervous systems of infected animals, causing progressive pneumonia and neurological symptoms. BIV, on the other hand, is more similar to Human Immunodeficiency Virus (HIV) and causes a bovine immunodeficiency syndrome, characterized by a decline in the immune function and increased susceptibility to other infections.

Both MVV and BIV are transmitted horizontally between animals through close contact with infected bodily fluids such as milk, colostrum, saliva, and semen, as well as vertically from infected cows to their offspring. Currently, there are no vaccines or specific treatments available for bovine lentivirus infections, and control measures focus on identifying and isolating infected animals to prevent the spread of the virus.

A genetic vector is a vehicle, often a plasmid or a virus, that is used to introduce foreign DNA into a host cell as part of genetic engineering or gene therapy techniques. The vector contains the desired gene or genes, along with regulatory elements such as promoters and enhancers, which are needed for the expression of the gene in the target cells.

The choice of vector depends on several factors, including the size of the DNA to be inserted, the type of cell to be targeted, and the efficiency of uptake and expression required. Commonly used vectors include plasmids, adenoviruses, retroviruses, and lentiviruses.

Plasmids are small circular DNA molecules that can replicate independently in bacteria. They are often used as cloning vectors to amplify and manipulate DNA fragments. Adenoviruses are double-stranded DNA viruses that infect a wide range of host cells, including human cells. They are commonly used as gene therapy vectors because they can efficiently transfer genes into both dividing and non-dividing cells.

Retroviruses and lentiviruses are RNA viruses that integrate their genetic material into the host cell's genome. This allows for stable expression of the transgene over time. Lentiviruses, a subclass of retroviruses, have the advantage of being able to infect non-dividing cells, making them useful for gene therapy applications in post-mitotic tissues such as neurons and muscle cells.

Overall, genetic vectors play a crucial role in modern molecular biology and medicine, enabling researchers to study gene function, develop new therapies, and modify organisms for various purposes.

Genetic transduction is a process in molecular biology that describes the transfer of genetic material from one bacterium to another by a viral vector called a bacteriophage (or phage). In this process, the phage infects one bacterium and incorporates a portion of the bacterial DNA into its own genetic material. When the phage then infects a second bacterium, it can transfer the incorporated bacterial DNA to the new host. This can result in the horizontal gene transfer (HGT) of traits such as antibiotic resistance or virulence factors between bacteria.

There are two main types of transduction: generalized and specialized. In generalized transduction, any portion of the bacterial genome can be packaged into the phage particle, leading to a random assortment of genetic material being transferred. In specialized transduction, only specific genes near the site where the phage integrates into the bacterial chromosome are consistently transferred.

It's important to note that genetic transduction is not to be confused with transformation or conjugation, which are other mechanisms of HGT in bacteria.

I'm sorry for any confusion, but "Puma" is not a term that has a medical definition. It is a common name for several species of large American cats, and it can also be a brand of sports apparel and footwear. If you have any other health or medical terms you would like me to define, please let me know!

"Cercopithecus" is a genus of Old World monkeys that are commonly known as guenons. These monkeys are native to Africa and are characterized by their colorful fur, long tails, and distinctive facial features. They are agile animals that live in a variety of habitats, including forests, savannas, and mountains.

The term "Cercopithecus" is derived from the Greek words "kerkos," meaning tail, and "pithekos," meaning ape or monkey. This name reflects the long tails that are characteristic of these monkeys.

There are several species of guenons within the genus "Cercopithecus," including the vervet monkey, the grivet, the tantalus monkey, and the de Brazza's monkey, among others. These monkeys are important members of their ecosystems and play a key role in seed dispersal and forest regeneration. They are also popular subjects of research due to their complex social structures and behaviors.

I'm sorry for any confusion, but "Lions" is not a term typically used in medical definitions. Lions are large, carnivorous mammals that are part of the Felidae family, specifically Panthera leo. If you have any questions about lions or if there's another term you meant to ask about, please provide more context so I can give you a more accurate response.

Feline lentiviruses are a group of retroviruses that cause long-standing, progressive diseases in cats. They are part of the larger family of lentiviruses, which also includes human immunodeficiency virus (HIV), the causative agent of AIDS in humans.

Feline lentiviruses are further classified into two types: feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV). Both viruses primarily affect the immune system, making infected cats more susceptible to other infections and diseases.

FIV is transmitted through bite wounds and sexual contact, while FeLV is spread mainly through close contact with infected cats, such as sharing food and water bowls or grooming each other. Kittens can also become infected with FeLV from their mothers during pregnancy or nursing.

Both FIV and FeLV infections can lead to a variety of clinical signs, including weight loss, fever, anemia, lymphadenopathy (swollen lymph nodes), and immune suppression. However, the progression and severity of the disease can vary widely between individual cats, with some animals showing few or no symptoms for many years.

There is no cure for feline lentivirus infections, but antiretroviral therapy (ART) can help manage the virus and improve the cat's quality of life. Supportive care, such as providing a nutritious diet, monitoring for secondary infections, and keeping the cat stress-free, is also important. Vaccines are available for FeLV but not for FIV, and regular veterinary check-ups are recommended to monitor the progression of the disease.

I'm happy to help, but I want to clarify that the term "sheep diseases" refers to a wide range of health issues that can affect sheep populations. It's not a single medical condition with a specific definition. Here are some examples of common diseases that can affect sheep:

1. Ovine Johne's Disease (OJD): A chronic, infectious disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It affects the intestines and can cause weight loss, diarrhea, and death.
2. Footrot: A highly contagious bacterial infection that affects the feet of sheep, causing lameness, swelling, and pain. It's caused by the bacteria Dichelobacter nodosus.
3. Caseous Lymphadenitis (CL): A chronic infectious disease caused by the bacterium Corynebacterium pseudotuberculosis. It affects the lymph nodes and can cause abscesses, weight loss, and death.
4. Contagious Ecthyma (Orf): A highly contagious viral infection that affects the skin and mucous membranes of sheep, causing sores and lesions.
5. Mastitis: An inflammation of the mammary gland in sheep, usually caused by a bacterial infection. It can cause decreased milk production, fever, and loss of appetite.
6. Pneumonia: A respiratory infection that can affect sheep, causing coughing, difficulty breathing, and fever. It can be caused by various bacteria or viruses.
7. Enterotoxemia: A potentially fatal disease caused by the overproduction of toxins in the intestines of sheep, usually due to a bacterial infection with Clostridium perfringens.
8. Polioencephalomalacia (PEM): A neurological disorder that affects the brain of sheep, causing symptoms such as blindness, circling, and seizures. It's often caused by a thiamine deficiency or excessive sulfur intake.
9. Toxoplasmosis: A parasitic infection that can affect sheep, causing abortion, stillbirth, and neurological symptoms.
10. Blue tongue: A viral disease that affects sheep, causing fever, respiratory distress, and mouth ulcers. It's transmitted by insect vectors and is often associated with climate change.

I believe there may be a misunderstanding in your question. "Goat diseases" refers to illnesses that affect goats specifically. It does not mean diseases that are caused by goats or related to them in some way. Here are some examples of goat diseases:

1. Caprine Arthritis Encephalitis (CAE): A viral disease that affects goats, causing arthritis, pneumonia, and sometimes encephalitis.
2. Caseous Lymphadenitis (CL): A bacterial disease that causes abscesses in the lymph nodes of goats.
3. Contagious Caprine Pleuropneumonia (CCPP): A contagious respiratory disease caused by mycoplasma bacteria.
4. Johne's Disease: A chronic wasting disease caused by a type of bacterium called Mycobacterium avium subspecies paratuberculosis.
5. Pasteurellosis: A bacterial disease that can cause pneumonia, septicemia, and other infections in goats.
6. Salmonellosis: A bacterial disease caused by Salmonella bacteria, which can cause diarrhea, fever, and septicemia in goats.
7. Soremouth (Orf): A viral disease that causes sores and scabs around the mouth and nose of goats.

These are just a few examples of diseases that can affect goats. If you have any specific questions about goat health or diseases, I would recommend consulting with a veterinarian who specializes in small ruminants.

I'm sorry for any confusion, but the term "Lemur" is not typically used in medical definitions. It is a common name that refers to primates belonging to the infraorder Lemuriformes. They are native to Madagascar and are divided into five families: Cheirogaleidae (dwarf lemurs), Daubentoniidae (aye-aye), Indriidae (indris, sifakas, and avahis), Lepilemuridae (sportive lemurs), and Lemuridae (true lemurs). If you have any questions related to medical terminology or health concerns, I would be happy to help!

Bovine Immunodeficiency Virus (BIV) is a retrovirus that primarily infects cattle. It is part of the lentivirus family, which also includes Human Immunodeficiency Virus (HIV).

Similar to HIV, BIV attacks the immune system by infecting and destroying CD4+ T cells, leading to a condition called immunodeficiency. However, it's important to note that BIV is not known to infect humans or other primates.

The virus is transmitted through bodily fluids, particularly blood and sexual contact. It can also be spread from mother to calf during pregnancy or birth.

While BIV can cause a disease similar to AIDS in cattle, it progresses much more slowly, often taking several years to manifest symptoms. These may include weight loss, diarrhea, respiratory infections, and other opportunistic infections due to the weakened immune system.

There is currently no vaccine or cure for BIV infection. Management typically involves supportive care and treatment of secondary infections.

Gene transfer techniques, also known as gene therapy, refer to medical procedures where genetic material is introduced into an individual's cells or tissues to treat or prevent diseases. This can be achieved through various methods:

1. **Viral Vectors**: The most common method uses modified viruses, such as adenoviruses, retroviruses, or lentiviruses, to carry the therapeutic gene into the target cells. The virus infects the cell and inserts the new gene into the cell's DNA.

2. **Non-Viral Vectors**: These include methods like electroporation (using electric fields to create pores in the cell membrane), gene guns (shooting gold particles coated with DNA into cells), or liposomes (tiny fatty bubbles that can enclose DNA).

3. **Direct Injection**: In some cases, the therapeutic gene can be directly injected into a specific tissue or organ.

The goal of gene transfer techniques is to supplement or replace a faulty gene with a healthy one, thereby correcting the genetic disorder. However, these techniques are still largely experimental and have their own set of challenges, including potential immune responses, issues with accurate targeting, and risks of mutations or cancer development.

Genetic therapy, also known as gene therapy, is a medical intervention that involves the use of genetic material, such as DNA or RNA, to treat or prevent diseases. It works by introducing functional genes into cells to replace missing or faulty ones caused by genetic disorders or mutations. The introduced gene is incorporated into the recipient's genome, allowing for the production of a therapeutic protein that can help manage the disease symptoms or even cure the condition.

There are several approaches to genetic therapy, including:

1. Replacing a faulty gene with a healthy one
2. Inactivating or "silencing" a dysfunctional gene causing a disease
3. Introducing a new gene into the body to help fight off a disease, such as cancer

Genetic therapy holds great promise for treating various genetic disorders, including cystic fibrosis, muscular dystrophy, hemophilia, and certain types of cancer. However, it is still an evolving field with many challenges, such as efficient gene delivery, potential immune responses, and ensuring the safety and long-term effectiveness of the therapy.

Animals showing the above symptoms might die within six months of infection. This causal lentivirus can be found in monocytes, ... Ryan S, Tiley L, McConnell I, Blacklaws B (November 2000). "Infection of Dendritic Cells by the Maedi-Visna Lentivirus". J. ... Larruskain, A.; Jugo, B. M. (2013). "Retroviral Infections in Sheep and Goats: Small Ruminant Lentiviruses and Host Interaction ... Visna-maedi virus (also known as Visna virus, Maedi-visna virus and Ovine lentivirus) from the genus Lentivirus and subfamily ...
Poli, A.; Abramo, F.; Cavicchio, P.; Bandecchi, P.; Ghelardi, E.; Pistello, M. (1995). "Lentivirus infection in an African lion ... Feline immunodeficiency virus and lentivirus also affect captive lions. When resting, lion socialisation occurs through a ...
Scientists use the lentivirus' mechanisms of infection to achieve a desired outcome to gene therapy. Lentiviral vectors in gene ... In gene therapy, adenoviruses differ from lentiviruses in many ways, some of which provide advantages over lentiviruses. ... There are multiple steps involved in the infection and replication of a lentivirus in a host cell. In the first step the virus ... The lentivirus is a retrovirus, meaning it has a single stranded RNA genome with a reverse transcriptase enzyme. Lentiviruses ...
Current research may suggest that equine foamy virus serves as a cofactor in the contraction of equine lentivirus infection. ... which is a characteristic unique to lentiviruses. It has also been found that upon persistent infection with EFV, the viral ... The magnitude of the infection can vary widely depending on the type of cell infected. While most infected cells display the ... Like other foamy viruses, infection with equine foamy virus is lifelong, yet the natural hosts do not display any pathological ...
... pushed the origin of SIV-like lentivirus infections in primates back to at least 14 Ma, the last time there was intermingling ... Unlike HIV-1 and HIV-2 infections in humans, SIV infections in their natural simian non-human hosts appear in many cases to be ... SIV infection of non-human primates (NHPs) invariably results in persistent infection, but rarely acute disease. Pathogenic ... The later stages of SIV infection develop into sAIDS, much like how HIV infection develops into AIDS. The simian (monkey-hosted ...
Higher rates of infection in males than females occurs due to biting being more frequently engaged in by males defending their ... Additionally, lentiviruses are also highly endemic in Africa infecting not only felids, but also primates, and ungulate species ... FIV and HIV are both lentiviruses. However, humans cannot be infected by FIV, nor can cats be infected by HIV. FIV is ... A vigilant pet owner who treats secondary infections can allow an infected cat to live a reasonably long life. The chance that ...
A federal lawsuit was filed by a scientist claiming she got an infection by a genetically modified lentivirus while working for ... By 2012, the rate of invasive infections among children under age 5 had been reduced by an additional 50%. In 2010, Ian Read ... In 1981, the company received approval for Diflucan (fluconazole), the first oral treatment for severe fungal infections ... this is used for the prevention of invasive pneumococcal infections. The introduction of the original, 7-valent version of the ...
... or ovine lentivirus, a chronic infection of Visna virus that affects sheep Yamaha YM2164, an FM synthesis sound chip also ...
... of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses ...
... was due to the cross-species infections of humans by lentiviruses of primate origin. A careful analysis of the high degree of ... which showed a much lower SIVcpz infection rate in contrast to other naturally occurring SIV infections. This finding indicated ... The simian versions of the virus (known as SIVcpz in chimpanzees, and SIVgor in gorillas) became the infection named HIV in ... It was at this period that she began to specialise in zoonoses or infections which can be transmitted between species, and ...
Lentiviruses, Sexually transmitted diseases and infections, 1983 in biology). ... Lentiviruses have many morphologies and biological properties in common. Many species are infected by lentiviruses, which are ... HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T ... When simultaneous infection occurs, the genome of progeny virions may be composed of RNA strands from two different strains. ...
... swollen lymph nodes and susceptibility to other severe infections HIV is a type of lentivirus of which two types are known to ... Isolated infection -An isolated infection of a new host with no further infection within the new species -Spillovers into dead- ... The early isolated infection events exposes the pathogen to the selection pressure of survival in that new species of which ... However, this balance must be brought under control for the pathogen to maintain its infection in the new host and not burn ...
Another primate lentivirus, SIV, also, counteracts tetherin by their removal from the plasma membrane. KSHV protein K5 also ... Initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu, tetherin has also been shown to inhibit the ... Royer DJ, Carr DJ (July 2016). "A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via ... Tetherin is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after ...
Lentiviral infection has advantages over other gene-therapy methods including high-efficiency infection of dividing and non- ... ISBN 978-1-4511-0563-6. ICTV taxonomy of Lentivirus "Lentiviruses In Ungulates. I. General Features, History And Prevalence" ( ... Lentiviruses are distributed worldwide, and are known to be hosted in apes, cows, goats, horses, cats, and sheep as well as ... Lentivirus is primarily a research tool used to introduce a gene product into in vitro systems or animal models. Large-scale ...
Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. (1988) Feline T-lymphotropic lentivirus ...
... htlv-ii infections MeSH C02.782.815.200.480.350 - leukemia, t-cell, htlv-ii-associated MeSH C02.782.815.616 - lentivirus ... cardiovirus infections MeSH C02.782.687.207 - common cold MeSH C02.782.687.359 - enterovirus infections MeSH C02.782.687.359. ... deltaretrovirus infections MeSH C02.782.815.200.260 - enzootic bovine leukosis MeSH C02.782.815.200.470 - htlv-i infections ... avulavirus infections MeSH C02.782.580.600.080.600 - newcastle disease MeSH C02.782.580.600.400 - henipavirus infections MeSH ...
IFITM proteins also are able to inhibit several infection with other enveloped viruses that belong to different virus families ... and lentiviruses (Human Immunodeficiency Virus (HIV)). However, IFITM proteins did not affect alphavirus, arenavirus, or murine ... "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal. ... leukaemia virus infection. IFITM proteins inhibit viral membrane and cellular endosomal or lysosomal vesicle membrane fusion by ...
Common laboratory vectors of transduction such as lentivirus cause immune responses in humans, so proposed human therapies ... often centered around adeno-associated virus (AAV) because AAV infections are largely asymptomatic. Unfortunately, the ...
The initial stages of these infections mimic infection with natural viruses and lead to expression of the genes transferred and ... in the case of lentivirus/retrovirus vectors) insertion of the DNA to be transferred into the cellular genome. However, since ... the transferred genetic material does not encode any of the viral genes, these infections do not generate new viruses (the ...
Terrestrial alphavirus infections are spread by insect vectors such as mosquitoes. Once a human is bitten by the infected ... Alphaviral envelope pseudotypes of retroviruses or lentiviruses are able to integrate the genes that they carry into the ... The neutralizing antibodies also play an important role to prevent further infection and spread. Diagnoses is based on clinical ... Neither of these limitations extend to alphaviral envelope pseudotypes of retroviruses or lentiviruses. However, the expression ...
However, HIV-1 has evolved to circumvent the innate immune response and establishes disseminated infection. It was reported ... Macrophages and dendritic cells are usually the first point of contact with pathogens, including lentiviruses. Host restriction ... The clinical disease presents in the perinatal period with life-threatening autoinflammation that mimics TORCH infections, but ... in the absence of infection. The severe inflammation results from a failure to regulate type I IFN activity, and is therefore ...
HIV infection was first described in 1981 in San Francisco and New York City. In 1985, HIV was identified as the causative ... Human immunodeficiency virus (HIV) is a lentivirus that has two major species, HIV-1 which causes the majority of the epidemic ... HIV-2 carries a slightly lower risk of transmission than HIV-1 and infection tends to progress more slowly to AIDS. In common ... inhibition of the HIV protease is one of the most important approaches for the therapeutic intervention in HIV infection and ...
... after an infection, each virus generates only one provirus. After infection, reverse transcription occurs and this process is ... This is unlike Lentivirus, a genus of Retroviridae, which are able to integrate their RNA into the genome of non-dividing host ... The lentivirus genus, the spumavirus genus, the HTLV / bovine leukemia virus (BLV) genus, and a newly introduced fish virus ... Lentiviruses (slow viruses) include HIV-1 and HIV-2, the cause of acquired immune deficiency syndrome (AIDS) in humans. ...
... which raises concerns for possible applications of lentiviruses in gene therapy. However, studies have shown that lentivirus ... Such a virus can efficiently infect cells but, once the infection has taken place, requires a helper virus to provide the ... To produce a lentivirus, several plasmids are transfected into a so-called packaging cell line, commonly HEK 293. One or more ... Lentiviruses are a subclass of retroviruses. They are sometimes used as vectors for gene therapy thanks to their ability to ...
It has been suggested that Tat antagonists may be of use in the treatment of HIV infections. Biosantech has developed a novel ... Like other lentiviruses, HIV-1 encodes a trans-activating regulatory protein (Tat), which is essential for efficient ... early in the course of infection, allowing the more rapidly pathogenic T-tropic (T-cell-tropic) strains (which use the CXCR4 ...
February 2023). "Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis". The Lancet ... at least two lentivirus vector vaccines, a conjugate vaccine, and a vesicular stomatitis virus displaying the SARS‑CoV‑2 spike ... The rapidly growing infection rate of COVID‑19 worldwide during 2020 stimulated international alliances and government efforts ... Lovelace Jr B (19 July 2022). "Nasal vaccines may stop Covid infections. Will we get them soon?". NBC News. Archived from the ...
Antigen analysis on select Florida panther populations has shown evidence of feline immunodeficiency virus and puma lentivirus ... consistently positive results for the presence of infection is difficult to find. In the 2002-2003 capture season, feline ... Miller, D.L.; Taylor, Rotstein; Pough, Barr (April 2006). "Feline Immunodeficiency Virus and Puma Lentivirus in Florida ...
Katzourakis A, Tristem M, Pybus OG, Gifford RJ (April 2007). "Discovery and analysis of the first endogenous lentivirus". ... For example, some protect against infection with related viruses. In some mammal groups, including higher primates, retroviral ... and 12 million years for the Lentivirus genus of the Retroviridae family. EVEs also facilitate the use of molecular clock-based ...
... a respiratory infection of cats. Feline calicivirus (FCV), a common viral cause of respiratory infection in cats. Feline ... Viruses for which there are no vaccines: Feline immunodeficiency virus (FIV), a lentivirus and genetic relative of HIV. There ... Timely vaccination can reduce the risk and severity of an infection. The most commonly recommended viruses to vaccinate cats ...
Adeno-associated virus, Lentivirus based vectors have been to introduce the genome for the CRISPR system.: 6 The delivery of ... In a phase I clinical trial, five subjects with chronic HIV infection who had failed to respond to at least two antiretroviral ... In 2007, a rheumatoid arthritis patient died from an infection; the subsequent investigation concluded that the death was not ... The other children had Wiskott-Aldrich syndrome, which leaves them to open to infection, autoimmune diseases, and cancer. ...
  • Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus. (ac.ir)
  • These viruses are the remnants of past infections that have become incorporated in their hosts genome (about 10% of the human genome is made up of segments of retrovirus). (nottingham.ac.uk)
  • Infections with viruses of the order MONONEGAVIRALES. (edu.au)
  • Viruses such as lentiviruses that are responsible for long lasting infections have to evade several levels of cellular immune mechanisms to persist and efficiently disseminate in the host. (frontiersin.org)
  • During their replication cycle, viruses, notably lentiviruses, have to face several levels of the host immune defense mechanisms and must counteract these barriers to persist and disseminate in the host. (frontiersin.org)
  • They are only distantly related to the human immunodeficiency viruses (HIV-1 and HIV-2), which belong to the lentivirus subfamily of retroviruses and which cause acquired immunodeficiency syndrome (AIDS). (cdc.gov)
  • Papillomaviruses, adeno-associated viruses, lentiviruses (such as HIV-1) and herpesviruses are capable of establishing persistent infections by various mechanisms. (nih.gov)
  • Positive-sense, single-stranded, enclosed RNA viruses are how lentiviruses spread. (assignology.com)
  • A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. (bvsalud.org)
  • The human immunodeficiency virus (HIV) is a lentivirus included within a subgroup of retroviruses. (cdc.gov)
  • Genus of non-oncogenic retroviruses which establish persistent infections in many animal species but are considered non-pathogenic. (lookformedical.com)
  • Visna Maedi virus (VMV) belongs to the small ruminant lentivirus group (SRLV). (wikipedia.org)
  • An epidemiological study was conducted to identify risk factors related to small ruminant lentivirus (SRLV) infection in the central region of Spain. (visavet.es)
  • Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. (biomedcentral.com)
  • Genetic variation in the ovine transmembrane 154 ( TMEM154 ) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. (biomedcentral.com)
  • Sheep with a copy of either haplotype 2 or 3, both of which encode a glutamate amino acid residue at position 35 (E35) of the extracellular portion of TMEM154, have an increased risk of SRLV infection. (biomedcentral.com)
  • The biology responsible for TMEM154 E35K associations with SRLV infection susceptibility, and SRLV subgroup associations with TMEM154 E35K genotypes is unknown. (biomedcentral.com)
  • While a portion of TMEM154 is predicted to extend from the host cell into the external milieu, it is not known if TMEM154 serves as a receptor, or co-receptor for SRLV attachment to the host cell, affects viral processing within the cell, or exit from it, or has a different biological function regarding SRLV infection. (biomedcentral.com)
  • However, given that SRLV subgroups and TMEM154 E35K genotypes associate with each other through apparent coevolution, TMEM154 is implicated as having a critical role in SRLV infections, leading us to hypothesize that sheep lacking functional TMEM154 may be completely resistant to SRLV infection. (biomedcentral.com)
  • Small ruminant lentivirus (SRLV) infection causes losses in the small ruminant industry due to reduced animal production and increased replacement rates. (biomedcentral.com)
  • Infection of wild ruminants in close contact with infected domestic animals has been proposed to play a role in SRLV epidemiology, but studies are limited and mostly involve hybrids between wild and domestic animals. (biomedcentral.com)
  • Apparent restriction of SRLV infection in cervids was not related to the presence of neutralizing antibodies. (biomedcentral.com)
  • Thus, although direct detection of virus was not successfully achieved in vivo, these findings show the potential susceptibility of wild ruminants to SRLV infection in the case of red deer and, on the other hand, an in vivo SRLV restriction in fallow deer. (biomedcentral.com)
  • Altogether these results may highlight the importance of surveilling and controlling SRLV infection in domestic as well as in wild ruminants sharing pasture areas, and may provide new natural tools to control SRLV spread in sheep and goats. (biomedcentral.com)
  • The premature removal of infected animals and the consequent increased replacement rate is a major consequence of SRLV infection. (biomedcentral.com)
  • All zoonotic transfers of primate lentiviruses from species other primate samples were obtained with government approval from than chimpanzees and sooty mangabeys are possible. (cdc.gov)
  • Over the past decades, much evidence has emerged regarding the major role of accessory proteins of primate lentiviruses, human immunodeficiency virus and simian immunodeficiency virus, in viral evasion from the host immune defense. (frontiersin.org)
  • Prospects in innate immune responses as potential control strategies against non-primate lentiviruses. (ac.ir)
  • This causal lentivirus can be found in monocytes, lymphocytes and macrophages of infected sheep in the presence of humoral and cell mediated immune response and can also be detected by conducting several serological tests. (wikipedia.org)
  • Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)
  • So on day one, Session 1 will focus on macrophages and the immune system during HIV and SARS-CoV-2 infection, Session 2 will focus on challenges to study HIV/SIV reservoirs, and Session 3 will really have the highlights from recent awardees of the NIMH/NINDS/NIDA Myeloid Reservoir RFA. (nih.gov)
  • Spp lentivirus was mainly found in LDLR + macrophages and pneumocytes in the lungs, but not in MARC1 + macrophages. (biorxiv.org)
  • Visna-maedi virus (also known as Visna virus, Maedi-visna virus and Ovine lentivirus) from the genus Lentivirus and subfamily Orthoretrovirinae, is a retrovirus that causes encephalitis and chronic pneumonitis in sheep. (wikipedia.org)
  • Virus diseases caused by the Lentivirus genus. (edu.au)
  • The family Retroviridae includes the genus Lentivirus, which includes HIV, and this is how HIV is classified. (assignology.com)
  • Human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). (cdc.gov)
  • HIV can cause human infection of varying severity, with the most advanced form of infection referred to as acquired immunodeficiency syndrome (AIDS). (cdc.gov)
  • or (2) one of the identified clinical conditions listed as part of the AIDS surveillance case definition, which include infections such as extrapulmonary coccidioidomycosis or cryptococcosis, tuberculosis, Pneumocystis carinii pneumonia, and histoplasmosis, as well as some noninfectious conditions, such as Kaposi's sarcoma, some forms of lymphoma, and invasive cervical cancer. (cdc.gov)
  • Visna Maedi virus is a retrovirus meaning its genome consists of a (+)RNA that undergoes reverse transcription and then is integrated into the host's genome after infection. (wikipedia.org)
  • Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)
  • However, much evidence has highlighted their importance in the pathogenesis of the infection, as they contribute to modify the cell environment to facilitate viral replication and evasion from the host antiviral immune response ( Malim and Emerman, 2008 ). (frontiersin.org)
  • Mannose receptor may be involved in small ruminant lentivirus pathogenesis. (ac.ir)
  • METHODS: ACE2 and TMPRSS2 mRNA and protein expression, cell binding of SARS-CoV-2 S1 protein, cell entry of SARS-CoV-2 S protein-pseudotyped lentiviral particles, and SARS-CoV-2 cell infection were measured in kidney, lung, and intestinal epithelial cell lines, primary human bronchial epithelial cells, and ACE2-transfected HEK293T cells treated with OM-85 in vitro. (nih.gov)
  • Methods and Findings In this study, we developed a Spike protein-pseudotyped (Spp) lentivirus with the proper tropism of SARS-CoV-2 Spike protein on the surface and tracked down the fate of Spp in wild type C57BL/6J mice receiving intravenous injection of the virus. (biorxiv.org)
  • A polytropic caprine arthritis encephalitis virus promoter isolated from multiple tissues from a sheep with multisystemic lentivirus-associated inflammatory disease. (ac.ir)
  • Lentiviruses, which typically cause long-lasting infections with a prolonged incubation time, are present in many animals. (assignology.com)
  • SMALL ANIMAL MODELS OF LENTIVIRUS INFECTION FOR EVALUATING HIVTHERAPEUTICS NIH GUIDE, Volume 23, Number 33, September 16, 1994 RFP AVAILABLE: NIH-NIAID-DAIDS-95-17 P.T. Keywords: National Institute of Allergy and Infectious Diseases The Developmental Therapeutics Branch, Basic Research and Development Program, Division of AIDS, NIAID, NIH, has a requirement for the evaluation of antiviral therapies/strategies for HIV-1/AIDS in established small animal models of lentivirus infection. (nih.gov)
  • Infections (CROI) held February 13-16, 2017, in Seattle, Washington, and meetings with community that were hosted by the International AIDS Society and the Kaiser Family Foundation. (nih.gov)
  • These models will be key for developing therapeutic approaches for the treatment of patients suffering from NeuroAIDS and for understanding the basic biology of infection with HIV/AIDS. (nih.gov)
  • Persistent viral infections have been implicated in diseases such as AIDS and certain cancers. (nih.gov)
  • AIDS-Related Opportunistic Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "AIDS-Related Opportunistic Infections" by people in this website by year, and whether "AIDS-Related Opportunistic Infections" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "AIDS-Related Opportunistic Infections" by people in Profiles. (ouhsc.edu)
  • Development of AIDS-related malignancies and infections after starting HAART]. (ouhsc.edu)
  • Estimation of the prevalence of AIDS, opportunistic infections, and standard of care among patients with HIV/AIDS receiving care along the U.S.-Mexico border through the Special Projects of National Significance: a cross-sectional study. (ouhsc.edu)
  • Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections. (biomedcentral.com)
  • Thus, some SRLVs have adapted to infect sheep with distinct TMEM154 E35K genotypes and can influence TMEM154 E35K susceptibility to infection. (biomedcentral.com)
  • The susceptibility to maedi-visna infection varies across sheep breeds, with coarse-wool breeds apparently more susceptible than fine-wool sheep. (wikipedia.org)
  • Associations between small ruminant lentivirus infection and total milk yield and somatic cell count in a dairy sheep flock Vet Record. (nottingham.ac.uk)
  • 9. Impact of natural sheep-goat transmission on detection and control of small ruminant lentivirus group C infections. (nih.gov)
  • 11. Coxiella burnetii infections in sheep or goats: an opinionated review. (nih.gov)
  • As most of the NHP living in sub-Saharan Africa, they are naturally infected with their own simian lentivirus, SIVdeb. (nih.gov)
  • To assess human exposure to Simian immunodeficiency virus (SIV) in west central Africa, we looked for SIV infection in 788 monkeys that were hunted in the rainforests of Cameroon for bushmeat or kept as pets. (cdc.gov)
  • After infection of cells using LV-DSCR1 + , acridine orange and ethidium bromide staining was performed to investigation of apoptosis and autophagy. (techscience.com)
  • The cellular morphological changes related to apoptosis and autophagy was happened after 48 hours of viral infection. (techscience.com)
  • Clearance of Maedi Visna Infection in a longitudional study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele Journal of Medical Microbiology. (nottingham.ac.uk)
  • Some very important paradoxes exist with this naturally infected lentivirus model. (imrpress.com)
  • The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. (nih.gov)
  • In addition, there is a high risk of contracting life-threatening conditions like lymphomas, as well as severe bacterial infections, and tuberculosis. (assignology.com)
  • The genome of lentiviruses encodes for several accessory proteins such as Nef, Vif, Vpr, Vpx, and Vpu, in addition to the structural and enzymatic proteins Gag, Pol, and Env and the regulatory proteins Tat and Rev ( Malim and Bieniasz, 2012 ). (frontiersin.org)
  • Recent advances in the development of the SIV model system highlight the power of animal model systems for study of the mechanisms underlying the pathology associated with lentiviral infection in the nervous system. (nih.gov)
  • Understanding the mechanisms underlying lentiviruses evasion from host antiviral activities has been the focus of many studies of the past decades. (frontiersin.org)
  • The green tea catechin, epigallocatechin gallate (EGCG), has broad-spectrum antiviral activity, although its mechanisms against coronavirus (CoV) infection have remained unclear. (nature.com)
  • EGCG was demonstrated to inhibit authentic SARS-CoV-2 virus infection in vitro when added early during infection 10 , although the mechanisms remained unclear. (nature.com)
  • Conference in Programas Nacionales de Erradicaci n de Enfermedades (Tuberculosis y Brucelosis) en Ganado Bovino. (visavet.es)
  • IL6, IL10, CD80 and PPAR-γ were quickly upregulated in response to infection of Spp lentivirus in the lungs in vivo as well as in macrophage-like RAW264.7 cells in vitro . (biorxiv.org)
  • The in vivo efficacy of EGCG was highlighted in a murine model of HCoV-OC43 infection in which EGCG-fed mice had reduced viral burden in the lungs compared to untreated mice 12 . (nature.com)
  • Lentivirus particles provided by BrainVTA are pseudoviruses whose toxic genes have been removed and replaced by exogenous target genes. (brainvta.tech)
  • The numbers of bacteria translocated into the lower Transwell chamber were counted by dark field microscopy after infection for 2 h, 4 h and 8 h, and the permeability of endothelial monolayers to fluorescent particles were detected. (shsmu.edu.cn)
  • Here, we show that EGCG prevents human and murine CoV infection and blocks the entry of lentiviral particles pseudotyped with spike proteins from bat or highly pathogenic CoVs, including SARS-CoV-2 variants of concern, in lung epithelial cells. (nature.com)
  • If the lentivirus accidentally touches the skin, wash it immediately with plenty of water and disinfect it with alcohol. (brainvta.tech)
  • 19. Coxiella burnetii Infections in Small Ruminants and Humans in Switzerland. (nih.gov)
  • Lentivirus vector harboring DSCR1 (LV-DSCR1 + ) was constructed in HEK 293 cells and the optimal dosage of lentivirus vector for infection was determined by the MTT assay. (techscience.com)
  • The process is called a lentivirus vector. (nih.gov)
  • it also exhibited about 3-5 times more viral burden than VSV-G lentivirus in the lungs, liver, kidney and spleen. (biorxiv.org)
  • Thus, the mangabeys demonstrate a clear skew in their cytokine based immune response towards a predominantly TH2 bias which we believe is the reason why this species of mangabeys among the many studied, is perhaps is the only species that is susceptible to M. leprae infection (see Dr. B. Gormus's chapter). (imrpress.com)
  • Lentiviruses have the ability to infect both dividing and non-dividing cells, but it can cause immune response. (brainvta.tech)
  • Since the first cases of human immunodeficiency virus (HIV) infection were identified, the number of children infected with HIV has risen dramatically in developing countries, the result of an increased number of HIV-infected women of childbearing age in these areas. (medscape.com)
  • OM-85, a standardized lysate of human airway bacteria with strong immunomodulating properties and an impeccable safety profile, is widely used to prevent recurrent respiratory infections. (nih.gov)
  • Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). (ouhsc.edu)
  • Several investigations have indicated that the incidence of cervical cancer is closely related to human papillomavirus (HPV) infection ( 2 , 3 ). (spandidos-publications.com)
  • After the first infection, HIV can stay dormant in the human body for up to ten years when no symptoms are present. (assignology.com)
  • First described in 1954 by Bjorn Sigurdsson in Iceland, Maedi-visna virus was the first lentivirus to be isolated and characterized, accomplished in 1957 by Sigurdsson. (wikipedia.org)
  • The uncertainty regarding the identity of the infecting virus and the differing epidemiologic and clinical correlates of HTLV-I and HTLV-II infections have complicated counseling of HTLV-I/II-infected persons. (cdc.gov)
  • A lentivirus with vesicular stomatitis virus glycoprotein (VSV-G) was used as the control. (biorxiv.org)
  • Caprine arthritis-encephalitis virus relies partly on its ability to escape from innate immunity to cause persistent infections. (ac.ir)
  • Innate immune responses in hepatitis B virus (HBV) infection. (ac.ir)
  • The infection-fighting CD4 cells (CD4 T lymphocytes) are attacked by the virus and destroyed. (assignology.com)
  • PFU/ml:Plaque Forming Units/ml, it was used to calibrate the virus titer by measuring the number of plaques after virus infection. (brainvta.tech)
  • The disease progresses in three stages: acute HIV infection transitions into chronic and ultimately manifests as ADIS - acquired immune deficiency syndrome (World Health Organization, 2022). (assignology.com)
  • 17. Proteomics-based identification of immunodominant proteins of Brucellae using sera from infected hosts points towards enhanced pathogen survival during the infection. (nih.gov)
  • Findings of this work provide an evidence to understand the persistent infection and multiple system inflammation of CAEV. (ac.ir)
  • HTLV-I infection is endemic in southwestern Japan (10), the Caribbean basin (11), Melanesia (12), and in parts of Africa (13-15). (cdc.gov)
  • HIV multiplies quickly during the acute stage of infection and spreads throughout the body. (assignology.com)
  • However, this risk cannot be assessed since the prevalence, involved in the trade were asked for permission to sample diversity, and geographic distribution of SIV infections in wild blood and tissues from carcasses, which were then returned. (cdc.gov)
  • Immunohistochemical staining showed that 27.5% (14/51) of HCC patients had higher expression levels of DEPDC6/DEPTOR in the tumorous tissues than in tumor-adjacent tissues, especially among HCC patients with hepatitis B viral infection (odds ratio 10.3, 95% confidence interval [CI] 1.05-11.3) or patients with poor prognosis (death hazard ratio 4.51, 95% CI 1.60-12.7). (biomedcentral.com)
  • They are capable of infection but not replication, so they are safe to use. (brainvta.tech)
  • In some areas where HTLV-I infection is endemic, prevalence rates as high as 15% have been reported in the general population. (cdc.gov)
  • Clusters of HTLV-I infections have also been reported in blacks from the southeastern United States (16) and in immigrants from HTLV-I-endemic areas residing in Brooklyn, New York (17). (cdc.gov)
  • Heparan sulfate proteoglycans are a required attachment factor for SARS-CoV-2 and are shown here to be important in endemic HCoV-OC43 infection. (nature.com)
  • 16.Why does the overexpression (interference) effect disappear after a period of culture after establishing the lentivirus stable cell lines? (brainvta.tech)

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