Lymphatic Abnormalities
Encyclopedias as Topic
Favism
Vascular Malformations
A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.
Vicia faba
A plant species of the genus VICIA, family FABACEAE. The edible beans are well known but they cause FAVISM in some individuals with GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY. This plant contains vicine, convicine, Vicia lectins, unknown seed protein, AAP2 transport protein, and Vicia faba DNA-binding protein 1.
Lymphography
Mycoses
Elephantiasis, Filarial
FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome. (1/21)
Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously identified inactivating, nonsense and frameshift mutations in the forkhead transcription factor FOXC2 in affected members of LD families. To further delineate the relationship of FOXC2 deficiency to the clinical (and lymphangiodysplastic) phenotype in this syndrome, we performed dynamic lymphatic imaging and immunohistochemical examination of lymphatic tissues in mice heterozygous (+/-) for a targeted disruption of Foxc2. Adult heterozygote mice characteristically exhibited a generalized lymphatic vessel and lymph node hyper plasia and rarely exhibited hindlimb swelling. Retrograde lymph flow through apparently incompetent interlymphangion valves into the mesenteric nodes, intestinal wall and liver was also observed. In addition, Foxc2 +/- mice uniformly displayed distichiasis. We conclude that Foxc2 haploinsufficient mice mimic closely the distinctive lymphatic and ocular phenotype of LD patients. Furthermore, the craniofacial, cardiovascular and skeletal abnormalities sometimes associated with LD have previously been shown to be fully penetrant in homozygous Foxc2 null mice. This Foxc2 mutant mouse thus provides an ideal model for exploring molecular mechanisms and physiologic events in mesenchymal differentiation associated with lymphatic growth and development and the clinical abnormalities seen in human LD syndrome. (+info)An appropriate diagnostic workup for suspected vascular birthmarks. (2/21)
Birthmarks are common and commonly ignored by patients and primary care doctors. Yet they sometimes represent significant vascular anomalies that require diagnosis and treatment. We summarize when and how to work up a variety of vascular anomalies. (+info)Histopathological reporting of paediatric cutaneous vascular anomalies in relation to proposed multidisciplinary classification system. (3/21)
BACKGROUND: The terminology applied to vascular anomalies has been variable in previously published literature making interpretation suboptimal. The International Society for the Study of Vascular Anomalies (ISSVA) has proposed a revised classification based on clinical features and histopathological findings. This classification is increasingly being accepted as clinically useful and a platform for future studies. AIMS: To examine the extent to which the ISSVA classification can be practically applied to diagnostic histopathological specimens. METHODS: Cutaneous vascular lesions received in a single paediatric pathology unit during a 2-year period (2004-5) were reviewed, including glucose transporter protein 1 (GLUT1) immunostaining where required, and lesions were reclassified according to the ISSVA classification. RESULTS: 144 specimens were identified. Appropriate full clinical information was provided in only 17% of cases at submission. Infantile haemangiomas comprised 46% of cases, 18% of which were regressive type, initially inaccurately identified as vascular malformations before GLUT1 immunostaining. 30% of lymphatic malformations and all lymphovenous malformations were previously classified as vascular malformations, not otherwise specified. CONCLUSIONS: The ISSVA classification of vascular anomalies provides a useful framework for histopathologists to classify vascular anomalies. However, meaningful and appropriate use of such a system is dependent on the adequacy of clinical information provided and routine use of immunohistochemical markers. (+info)Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb. (4/21)
BACKGROUND: Mutations in the FOXC2 gene cause lymphedema distichiasis, an inherited primary lymphedema in which a significant number of patients have varicose veins. Because lymphedema distichiasis is believed to be caused by lymphatic valve failure (reflux), and FOXC2 is highly expressed on venous valves in mouse embryos, we tested the hypothesis that FOXC2 mutations may be linked to venous valve failure and reflux. METHODS AND RESULTS: The venous system of the leg was investigated with Duplex ultrasound. Pathological reflux was recorded by color Duplex ultrasound in all 18 participants with a FOXC2 mutation, including 3 without lymphedema. Every participant with a mutation in FOXC2 showed reflux in the great saphenous vein (n=18), compared with only 1 of 12 referents (including 10 family members; P<0.0001, Fisher exact test). Deep vein reflux was recorded in 14 of 18 participants. CONCLUSIONS: FOXC2 is the first gene in which mutations have been strongly associated with primary venous valve failure in both the superficial and deep veins in the lower limb. This gene appears to be important for the normal development and maintenance of venous and lymphatic valves. (+info)Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. (5/21)
Ras proteins signal through direct interaction with a number of effector enzymes, including type I phosphoinositide (PI) 3-kinases. Although the ability of Ras to control PI 3-kinase has been well established in manipulated cell culture models, evidence for a role of the interaction of endogenous Ras with PI 3-kinase in normal and malignant cell growth in vivo has been lacking. Here we generate mice with mutations in the Pi3kca gene encoding the catalytic p110alpha isoform that block its interaction with Ras. Cells from these mice show proliferative defects and selective disruption of signaling from growth factors to PI 3-kinase. The mice display defective development of the lymphatic vasculature, resulting in perinatal appearance of chylous ascites. Most importantly, they are highly resistant to endogenous Ras oncogene-induced tumorigenesis. The interaction of Ras with p110alpha is thus required in vivo for certain normal growth factor signaling and for Ras-driven tumor formation. (+info)Genetic causes of vascular malformations. (6/21)
Vascular malformations are localized defects of vascular development. They usually affect a limited number of vessels in a restricted area of the body. Although most malformations are sporadic, inheritance is observed, enabling genetic analysis. Usually, sporadic forms present with a single lesion whereas multiple lesions are observed in familial cases. The last decade has seen unraveling of several causative genes and beginning of elucidation of the pathophysiological pathways involved in the inherited forms. In parallel, definition of the clinical phenotypes has improved and disorders such as Parkes-Weber syndrome (PKWS), first thought to be sporadic, is now known to be part of a more common inheritable phenotype. In addition, the concept of double-hit mechanism that we proposed earlier to explain the incomplete penetrance, variable expressivity and multifocality of lesions in inherited venous anomalies is now becoming confirmed, as some somatic mutations have been identified in venous, glomuvenous and cerebral cavernous malformations. It is thus tempting to suggest that familial forms of vascular malformations follow paradominant inheritance and that sporadic forms, the etiopathogenic causes of which are still unelucidated, are caused by somatic mutations in the same genes. (+info)Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome: CNS malformations and seizures may be a component of this disorder. (7/21)
(+info)Paediatric vascular birthmarks--the psychological impact and the role of the GP. (8/21)
BACKGROUND: This study was designed to investigate the psychosocial impact on the family of a child with a vascular birthmark and examine the role of the general practitioner in meeting the family's needs. METHOD: Nineteen families were interviewed with a questionnaire before their assessment at the Sydney Children's Hospital (New South Wales) Vascular Birthmarks Clinic. RESULTS: Sixty-eight percent of parents overestimated the size of their child's lesion when asked to draw it; 15% said some lifestyle modifications had to be made to accommodate their child's condition; 63% were concerned about their child being teased at school; and 36% had issues of self blame and embarrassment. Expectations from the clinic included information (68%), treatment (47%) and reassurance (26%). CONCLUSION: Vascular birthmarks are common. Treatment strategies are improving, but there is a need to adequately address the psychosocial impact that these lesions have, both on parents and children. The GP is the carer best placed to meet these needs. (+info)'Lymphatic abnormalities' refer to any defects or disorders in the lymphatic system, including but not limited to, malformations, dysfunctions, or diseases in the lymph vessels, nodes, organs, or tissues, which can lead to a range of health issues like edema, immune system dysfunction, and susceptibility to infections.
Lymphatic abnormalities refer to conditions or defects that affect the lymphatic system, which is a part of the immune and circulatory systems. The lymphatic system includes a network of vessels, tissues, and organs that help rid the body of waste and toxins, fight infections, and maintain fluid balance.
Lymphatic abnormalities can occur due to genetic mutations, infections, inflammation, or cancer. These abnormalities may affect various components of the lymphatic system, including:
1. Lymph vessels: Abnormalities in lymph vessels can lead to a buildup of lymph fluid in certain parts of the body, causing swelling known as lymphedema.
2. Lymph nodes: Enlarged or abnormally shaped lymph nodes (lymphadenopathy) may indicate an infection, inflammation, or cancer.
3. Spleen: An enlarged spleen (splenomegaly) can be a sign of various conditions, such as infections, blood disorders, or cancer.
4. Thymus: Abnormalities in the thymus gland, which is part of the immune system, can lead to immunodeficiency disorders.
5. Tonsils and adenoids: Enlarged tonsils and adenoids can cause breathing and swallowing difficulties, especially in children.
6. Aggregated lymphatic tissue: Abnormalities in aggregated lymphatic tissue, such as Peyer's patches in the small intestine or the appendix, can increase the risk of infections and autoimmune disorders.
Lymphatic abnormalities can present with various symptoms, including swelling, pain, recurrent infections, and fatigue. Treatment depends on the underlying cause and may involve medications, surgery, or lifestyle changes.
'Lymphatic vessels' are thin-walled, blind-ended tubular structures that transport lymph fluid, containing immune cells and waste products, from the tissue spaces to the bloodstream, playing a crucial role in maintaining fluid balance and immunity.
Lymphatic vessels are thin-walled, valved structures that collect and transport lymph, a fluid derived from the interstitial fluid surrounding the cells, throughout the lymphatic system. They play a crucial role in immune function and maintaining fluid balance in the body. The primary function of lymphatic vessels is to return excess interstitial fluid, proteins, waste products, and immune cells to the bloodstream via the subclavian veins near the heart.
There are two types of lymphatic vessels:
1. Lymphatic capillaries: These are the smallest lymphatic vessels, found in most body tissues except for the central nervous system (CNS). They have blind ends and are highly permeable to allow the entry of interstitial fluid, proteins, and other large molecules.
2. Larger lymphatic vessels: These include precollecting vessels, collecting vessels, and lymphatic trunks. Precollecting vessels have valves that prevent backflow of lymph and merge to form larger collecting vessels. Collecting vessels contain smooth muscle in their walls, which helps to propel the lymph forward. They also have valves at regular intervals to ensure unidirectional flow towards the heart. Lymphatic trunks are large vessels that collect lymph from various regions of the body and eventually drain into the two main lymphatic ducts: the thoracic duct and the right lymphatic duct.
Overall, lymphatic vessels play a vital role in maintaining fluid balance, immune surveillance, and waste removal in the human body.
The lymphatic system is a complex network of organs, tissues, vessels (lymphatics) and cells that defend the body against infection, facilitate immune functions, and maintain fluid balance by draining and filtering lymph fluid from interstitial spaces throughout the body.
The lymphatic system is a complex network of organs, tissues, vessels, and cells that work together to defend the body against infectious diseases and also play a crucial role in the immune system. It is made up of:
1. Lymphoid Organs: These include the spleen, thymus, lymph nodes, tonsils, adenoids, and Peyer's patches (in the intestines). They produce and mature immune cells.
2. Lymphatic Vessels: These are thin tubes that carry clear fluid called lymph towards the heart.
3. Lymph: This is a clear-to-white fluid that contains white blood cells, mainly lymphocytes, which help fight infections.
4. Other tissues and cells: These include bone marrow where immune cells are produced, and lymphocytes (T cells and B cells) which are types of white blood cells that help protect the body from infection and disease.
The primary function of the lymphatic system is to transport lymph throughout the body, collecting waste products, bacteria, viruses, and other foreign substances from the tissues, and filtering them out through the lymph nodes. The lymphatic system also helps in the absorption of fats and fat-soluble vitamins from food in the digestive tract.
Equinus deformity is a condition characterized by the fixed plantar flexion of the ankle, which can involve soft tissue contractures and/or osseous abnormalities, leading to limited or impaired hindfoot and forefoot motion.
Equinus deformity is a condition in which the ankle remains in a permanently plantarflexed position, meaning that the toes are pointing downward. This limitation in motion can occur in one or both feet and can be congenital (present at birth) or acquired. Acquired equinus deformity can result from conditions such as cerebral palsy, stroke, trauma, or prolonged immobilization. The limited range of motion in the ankle can cause difficulty walking, pain, and abnormalities in gait. Treatment options for equinus deformity may include physical therapy, bracing, orthotic devices, or surgery.
"Encyclopedias, as a medical topic, refer to comprehensive and organized collections of information on various medical disciplines, theories, practices, diseases, treatments, and related health sciences, serving as extensive reference sources for medical professionals, students, researchers, and general public." (29 words)
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
'Favism' is a genetic disorder where individuals lack the enzyme glucose-6-phosphate dehydrogenase, leading to hemolysis (destruction of red blood cells) upon ingestion of fava beans or exposure to their pollen.
Favism is a genetic disorder that results in a sensitivity to broad beans (Vicia faba) and related plants. It is most commonly found in populations from the Mediterranean, Middle East, and Asia. The disorder is caused by a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD), which is necessary for protecting red blood cells from damage.
When individuals with favism eat broad beans or inhale their pollen, the beans' metabolites can cause the release of harmful oxidative agents that destroy red blood cells, leading to hemolytic anemia. Symptoms of favism can include weakness, fatigue, abdominal pain, dark urine, and jaundice. In severe cases, it can lead to kidney failure, seizures, or even death.
Avoiding broad beans and related plants is the primary treatment for favism. In some cases, blood transfusions or medications that boost red blood cell production may be necessary to manage symptoms. It's important to note that not all people with G6PD deficiency will develop favism, and not all people with favism have G6PD deficiency.
'Vascular malformations' are abnormal tangles or channels of blood vessels that can be present at birth or develop later, which may lead to various clinical manifestations depending on the type, size and location of the lesion.
Vascular malformations are abnormalities in the development and growth of blood vessels and lymphatic vessels that can occur anywhere in the body. They can be present at birth or develop later in life, and they can affect both the form and function of the affected tissues and organs. Vascular malformations can involve arteries, veins, capillaries, and/or lymphatic vessels, and they can range from simple, localized lesions to complex, multifocal disorders.
Vascular malformations are typically classified based on their location, size, flow characteristics, and the type of blood or lymphatic vessels involved. Some common types of vascular malformations include:
1. Capillary malformations (CMs): These are characterized by abnormal dilated capillaries that can cause red or pink discoloration of the skin, typically on the face or neck.
2. Venous malformations (VMs): These involve abnormal veins that can cause swelling, pain, and disfigurement in the affected area.
3. Lymphatic malformations (LMs): These involve abnormal lymphatic vessels that can cause swelling, infection, and other complications.
4. Arteriovenous malformations (AVMs): These involve a tangled mass of arteries and veins that can cause high-flow lesions, bleeding, and other serious complications.
5. Combined vascular malformations: These involve a combination of different types of blood or lymphatic vessels, such as capillary-lymphatic-venous malformations (CLVMs) or arteriovenous-lymphatic malformations (AVLMs).
The exact cause of vascular malformations is not fully understood, but they are believed to result from genetic mutations that affect the development and growth of blood vessels and lymphatic vessels. Treatment options for vascular malformations depend on the type, size, location, and severity of the lesion, as well as the patient's age and overall health. Treatment may include medication, compression garments, sclerotherapy, surgery, or a combination of these approaches.
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I'm not aware of any medical definition for the term "Boston." It is a city in the state of Massachusetts, USA, and is widely known for its cultural institutions, such as Boston Symphony Orchestra, Boston Ballet, and The Museum of Fine Arts. Additionally, it is home to many renowned medical institutions, including Massachusetts General Hospital, Brigham and Women's Hospital, and Dana-Farber Cancer Institute. However, "Boston" does not have a specific meaning or definition in the medical field.
'Vicia faba', also known as broad bean or fava bean, is a species of legume widely cultivated for its edible seeds and young shoots, containing essential nutrients and amino acids, but can cause favism, an inherited disorder affecting red blood cells, in susceptible individuals.
'Vicia faba' is the scientific name for the fava bean plant, which belongs to the legume family (Fabaceae). It is also known as broad bean or horse bean. The plant is widely cultivated as a vegetable crop, and its seeds, pods, and young leaves are all edible. Fava beans are rich in proteins, dietary fiber, vitamins, and minerals, making them an essential component of many diets around the world. However, some people may have an adverse reaction to fava beans due to a genetic disorder called favism, which can cause hemolytic anemia.
Lymphedema is a chronic condition characterized by swelling in parts of the body, typically an arm or leg, due to a buildup of lymph fluid after lymph vessels or nodes have been removed or damaged.
Lymphedema is a chronic condition characterized by swelling in one or more parts of the body, usually an arm or leg, due to the accumulation of lymph fluid. This occurs when the lymphatic system is unable to properly drain the fluid, often as a result of damage or removal of lymph nodes, or because of a genetic abnormality that affects lymphatic vessel development.
The swelling can range from mild to severe and may cause discomfort, tightness, or a feeling of heaviness in the affected limb. In some cases, lymphedema can also lead to skin changes, recurrent infections, and reduced mobility. The condition is currently not curable but can be managed effectively with various treatments such as compression garments, manual lymphatic drainage, exercise, and skincare routines.
Lymphography is a radiological imaging technique that involves the injection of a contrast medium into the lymphatic system to assess its structure, function, and any pathological conditions such as tumors or blockages.
Lymphography is not a commonly used term in current medical practice. However, historically, it referred to a radiographic imaging technique that involved the injection of a contrast material into the lymphatic system to visualize the lymph nodes and lymph vessels. This procedure was used primarily for diagnostic purposes, particularly in the evaluation of cancerous conditions like lymphoma or melanoma.
The process typically involved injecting a radiopaque substance into the interstitial tissue, which would then be taken up by the lymphatic vessels and transported to the regional lymph nodes. X-ray imaging was used to track the progression of the contrast material, creating detailed images of the lymphatic system.
Due to advancements in medical imaging technology, lymphography has largely been replaced by other non-invasive imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. These modern methods provide high-resolution images of the body's internal structures without requiring invasive procedures or the use of contrast materials.
Lymphoscintigraphy is a nuclear medicine procedure that involves the injection of a radioactive tracer into the area of interest, to evaluate the lymphatic system's anatomy and function, primarily used in diagnosing and staging cancer and identifying sentinel lymph nodes.
Lymphoscintigraphy is a medical imaging technique that uses radioactive tracers to examine the lymphatic system, specifically the lymph nodes and vessels. In this procedure, a small amount of radioactive material is injected into the area of interest, usually an extremity or the site of a surgical incision. The tracer then travels through the lymphatic channels and accumulates in the regional lymph nodes. A specialized camera called a gamma camera detects the radiation emitted by the tracer and creates images that reveal the function and anatomy of the lymphatic system.
Lymphoscintigraphy is often used to diagnose and assess conditions affecting the lymphatic system, such as lymphedema, cancer metastasis to lymph nodes, or unusual lymphatic flow patterns. It can help identify sentinel lymph nodes (the first node(s) to receive drainage from a tumor) in patients with melanoma and breast cancer, which is crucial for surgical planning and staging purposes.
In summary, lymphoscintigraphy is a non-invasive imaging technique that utilizes radioactive tracers to visualize the lymphatic system's structure and function, providing valuable information for diagnostic and therapeutic decision-making in various clinical scenarios.
Mycoses are a group of diseases caused by fungal pathogens that can infect various tissues and organs, potentially leading to localized or systemic symptoms, depending on the immune status of the host.
Mycoses are a group of diseases caused by fungal infections. These infections can affect various parts of the body, including the skin, nails, hair, lungs, and internal organs. The severity of mycoses can range from superficial, mild infections to systemic, life-threatening conditions, depending on the type of fungus and the immune status of the infected individual. Some common types of mycoses include candidiasis, dermatophytosis, histoplasmosis, coccidioidomycosis, and aspergillosis. Treatment typically involves antifungal medications, which can be topical or systemic, depending on the location and severity of the infection.
Elephantiasis, filarial, also known as lymphatic filariasis, is a neglected tropical disease caused by infection with parasitic filarial worms (Wuchereria bancrofti, Brugia malayi, and Brugia timori) that leads to chronic progressive inflammation and fibrosis of the lymphatic system, resulting in grossly enlarged and disfigured limbs or genital organs.
Elephantiasis, filarial is a medical condition characterized by the severe swelling of limbs or other parts of the body due to the blockage of lymphatic vessels by parasitic worms. It is caused by infection with threadlike nematode filarial worms, such as Wuchereria bancrofti and Brugia timori. These worms are transmitted to humans through mosquito bites.
The blockage of lymphatic vessels leads to the accumulation of lymph fluid in the affected area, causing progressive swelling, thickening, and hardening of the skin and underlying tissues. In advanced cases, the skin may become rough, nodular, and fissured, resembling the hide of an elephant, hence the name "elephantiasis."
The condition is usually chronic and can cause significant disability and social stigma. While there is no cure for filarial elephantiasis, various treatments are available to alleviate symptoms, prevent transmission, and halt the progression of the disease. These include antibiotics to kill the worms, surgery to remove the lymphatic obstruction, and various supportive measures to manage the swelling and prevent secondary infections.
'Arm' is a medical term referring to the upper limb of the human body, extending from the shoulder to the wrist and containing three major components: the upper arm (brachium), forearm (antebrachium), and elbow region (cubitus).
In medical terms, the arm refers to the upper limb of the human body, extending from the shoulder to the wrist. It is composed of three major bones: the humerus in the upper arm, and the radius and ulna in the lower arm. The arm contains several joints, including the shoulder joint, elbow joint, and wrist joint, which allow for a wide range of motion. The arm also contains muscles, blood vessels, nerves, and other soft tissues that are essential for normal function.
Fibro-adipose vascular anomaly
FAVA also causes venous and/or lymphatic abnormalities. Though FAVA has only been recognized as a distinct vascular anomaly, ... Organizing thrombi, lymphatic foci and enlarged nerves encircled by dense fibrous tissue are also frequently noted in FAVA.[ ... April 2015). "Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA". The ... April 2015). "Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA". The ...
Bronchitis
Some cases may result from abnormalities in the lymphatic vessels. Advanced cases may show imaging similarities to ... These differ from the casts seen in people whose plastic bronchitis is associated with congenital heart disease or lymphatic ... vessel abnormalities mainly because eosinophils and Charcot-Leyden crystals are present in the asthma-associated casts but not ...
Protein losing enteropathy
Congenital molecular abnormalities, or dysfunctional lymphatic drainage might cause epithelial matrix changes. Proteoglycans, ... This may be due to primary or congenital disease states of the lymphatic system or secondary (acquired) damage to the lymphatic ... Certain infections such as Whipple disease can also lead to impaired lymphatic drainage by destroying the lymphatic lacteals, ... The lymphatic system drains into the central venous system following a negative pressure gradient to the subclavian vein via ...
Lymphangioleiomyomatosis
Abnormalities on abdominal imaging, such as renal AML and enlarged lymphatic structures, are also common in LAM. Fat density ... recruit lymphatic endothelial cells (LECs) that form lymphatic vessels and induce lung cysts. VEGF-D serum levels are increased ... LAM lesions express lymphatic markers LYVE-1, PROX1, podoplanin and VEGFR-3. The smooth muscle-like cells of AMLs are ... Central nervous system abnormalities, such as cortical or subependymal tubers and astrocytomas, are common in patients with TSC ...
Diffuse capillary malformation with overgrowth
MRI is indicated if there is presence of lymphatic vessels, edema, or large veins. Similarly, AVMs are not present with DCMO, ... Typically there are no bone abnormalities on imaging. However, leg length discrepancy is observed in approximately half of ... Presence of neurological abnormality or macrocephaly can suggest macrocephaly-capillary malformation syndrome. Hemihypertrophy- ... Patients with DCMO have not been reported to have developmental or neurological abnormalities, thus neuroimaging is not ...
Lymphangioma
The lymphatic system is the network of vessels responsible for returning to the venous system excess fluid from tissues as well ... Vesicles or other skin abnormalities may not be noticed until several years after birth. Usually, lesions are asymptomatic or ... Lymphatic and radiographic studies support Whimsters observations. Such studies reveal that big cisterns extend deeply into the ... Whimster theorized the cisterns might come from a primitive lymph sac that failed to connect with the rest of the lymphatic ...
Emberger syndrome
These genetic abnormalities are known causes of acute myeloid leukemia and, while not essential for, may contribute to the ... fluid retention and tissue swelling caused by a compromised lymphatic system) of the lower limbs, and sensorineural hearing ... The syndrome includes as its primary symptoms: serious abnormalities of the blood such as the myelodysplastic syndrome and ... genetic abnormalities that often develop during the course of these disorders. Because of these many complexities, recent ...
CLOVES syndrome
Patients with CLOVES have different venous, capillary, and lymphatic channels - typically capillary, venous and lymphatic ... V is for vascular malformations, which are blood vessel abnormalities. ...
Stasis papillomatosis
Although direct lymphography of his lower extremities showed no abnormality, indirect lymphography revealed local lymphatic ... Lymphatic edema can be developed in many acral cases accompanied by a thickening of the folds of the skin, hyperkeratosis and ... Lymphatic obstruction due to any cause can increase the amount of proteins in the intravascular tissue, either by root osmotic ... As dermal lymphatic stasis progreses, these skin changes become more marked and known as elephantiasis. Occasionally, tissue ...
Tilak Weerasooriya
"Can varicocelectomy Improve the Seminal Fluid Parameter Abnormalities?." (2012). Fernando, H. H. L. K., R. Senevirathne, P. M. ... "POSTNATAL-DEVELOPMENT AND THE 3-DIMENSIONAL ORGANIZATION OF THE TESTICULAR LYMPHATICS IN THE RAT." In JOURNAL OF ELECTRON ... "POSTNATAL-DEVELOPMENT AND THE 3-DIMENSIONAL ORGANIZATION OF THE TESTICULAR LYMPHATICS IN THE RAT." In JOURNAL OF ELECTRON ... Can varicocelectomy Improve the Seminal Fluid Parameter Abnormalities? kdu.ac.lk Fernando, Hhlk (2014). "Can Clomiphene Citrate ...
Gorham's disease
Abnormalities of the remaining bones of the arm and shoulder are noted and the authors report that the arteries, veins, and ... No mention was made of lymphatic vessels. Though several reports of similar cases were published in the interim, more than 80 ... Lala S, Mulliken JB, Alomari AI, Fishman SJ, Kozakewich HP, Chaudry G. Gorham-Stout disease and generalized lymphatic anomaly- ... Trenor, C, Chaudry G. Complex lymphatic anomalies, Semin Pediatr Surg. 2014 Aug;23(4):186-90. doi:10.1053/j.sempedsurg.2014.07. ...
Cystic hygroma
... to evaluate for genetic abnormalities in the fetus. Lymphatic malformations may be discovered postnatally or in older children/ ... Cystic hygromas occur when the lymphatic vessels that make up the lymphatic system are not formed properly. The two types of ... Also known as cystic lymphangioma and macrocystic lymphatic malformation, the growth is often a congenital lymphatic lesion of ... Lymphatic malformations may be detected in the human fetus by ultrasound if they are of sufficient size. Detection of a cystic ...
Simone Mayer
Membrane markers, karyotypic abnormalities, ultrastructure and functional properties of lymphocytes in a case of 'D-cell' ... chronic lymphatic leukemia » Leukemia Research 1984;8(2):223-237 Aleksijevic, Alexandre ; Falkenrodt, Annie ; Lang, Jean-Marie ...
Gwendalyn J. Randolph
Randolph's lab developed a three-dimensional imaging approach to explore lymphatic vasculature abnormalities in human ... They showed that lymphatic vessels are critical to the mobilization of cholesterol for excretion and that enhancing lymphatic ... Her lab then showed that collecting lymphatic vessels (CLVs) are involved in the immune response by acting as a site for ... One objective was to determine if macrophages could migrate out of organs, via lymphatics or blood, in healthy or diseased ...
Sensorineural hearing loss
... lymphatic, and/or other disorders. GATA2 deficiency-induced abnormalities in the lymphatic system are proposed to be ... Some may be single point mutations, whereas others are due to chromosomal abnormalities. Some genetic causes give rise to a ... Hypoplastic auditory nerves or abnormalities of the cochlea. Abnormal development of the inner ear can occur in some genetic ...
List of MeSH codes
... hemic and lymphatic diseases C16 - congenital, hereditary, and neonatal diseases and abnormalities C17 - skin and connective ...
MonoMAC
... lymphatic, and/or other disorders that may begin as apparently benign abnormalities but commonly progress to severe organ (e.g ...
Pericardial effusion
Any process that leads to injury or inflammation of the pericardium and/or inhibits appropriate lymphatic drainage of the fluid ... Pericardial effusion usually results from a disturbed equilibrium between these two processes or from a structural abnormality ... aortic dissection Reduced lymphatic drainage: congestive heart failure, nephrotic syndrome How much fluid is stored in the ... while the fluid that is drained is mostly via the parietal lymphatic capillaries. ...
GATA2 deficiency
... lymphatic, or other presentations that may begin as apparently benign abnormalities but commonly progress to severe organ (e.g ... Lymphatic: lymphedema, i.e. fluid retention and tissue swelling caused by a compromised lymphatic system of the lower ... These presentations typically occur alongside of or are followed by hematologic abnormalities including but often only after ... lymphatic-forming, and other tissue-forming stem cells. In consequence of these mutations, cellular levels of GATA2 are ...
Severe congenital neutropenia
... lymphatic, or other presentations that may begin as apparently benign abnormalities but commonly progress to a more serious ... These syndrome subtypes are phenotypically similar despite arising from different gene abnormalities. Kostmann disease is a ... SCN4 is associated with structural cardiac abnormalities, enlarged liver, intermittent thrombocytopenia and a prominent ...
Cutis marmorata telangiectatica congenita
Histological examination of a biopsy may show an increase in the number and size of capillaries and veins (rarely lymphatics), ... In general, there is no treatment available for CMTC, although associated abnormalities can be treated. In the case of limb ... The prognosis is favorable in most patients with an isolated cutaneous abnormality. In the majority of cases, both the vivid ... Associated abnormalities include the following: Body asymmetry (extremities; macrocephaly) Glaucoma Cutaneous atrophy ...
Gallbladder
Lymphatics from the lower part of the organ drain into lower hepatic lymph nodes. All the lymph finally drains into celiac ... These abnormalities are not likely to affect function and are generally asymptomatic. The location of the gallbladder in ... The serosa contains blood vessels and lymphatics. The surfaces in contact with the liver are covered in connective tissue. The ... Lymphatic drainage of the gallbladder follows the cystic node, which is located between the cystic duct and the common hepatic ...
Noonan syndrome
Spinal abnormalities may be present up to 30% of the time and this may require surgery to correct in over 60% of these cases. ... Cardiofaciocutaneous (CFC) syndrome - CFC syndrome is very similar to Noonan's Syndrome due to similar cardiac and lymphatic ... Abnormalities in the limbs and extremities may occur in Noonan syndrome. This may manifest as bluntly ended fingers, extra ... Periodic follow up and lifelong monitoring of abnormalities found in any system, especially the cardiovascular system, is ...
Sclerotherapy
It is used for children and young adults with vascular or lymphatic malformations. In adults, sclerotherapy is often used to ... Sclerotherapy often[quantify] takes place under ultrasound guidance after venous abnormalities have been diagnosed with duplex ... and also malformations of the lymphatic system. A medicine is injected into the vessels, which makes them shrink. ...
Lymphedema
... swelling that results from abnormalities in the lymphatic system that are present from birth. Swelling may be present in a ... lymphatic, and other disorders. GATA2 deficiency-induced defects in the lymphatic vessels and valves underlies the development ... is a condition of localized swelling caused by a compromised lymphatic system. The lymphatic system functions as a critical ... When lymphatic impairment becomes so great that the collected lymph fluid exceeds the lymphatic system's ability to transport ...
Primary lymphedema
This type of lymphedema usually develops as a result of a developmental abnormality being precipitated by some insult such as ... Cutaneous Changes in Peripheral Venous and Lymphatic Insufficiency. In: Wolff K, ed. Fitzpatrick's Dermatology in General ... lymphatic vessels and lymph nodes, All stub articles, Oncology stubs). ...
List of skin conditions
Fawcett RS, Linford S, Stulberg DL (2004). "Nail abnormalities: clues to systemic disease". Am Fam Physician. 69 (6): 1417-24. ... or lymphatics in the subcutaneous tissues. Aagenaes syndrome Acroangiodermatitis (acroangiodermatitis of Mali, Mali ... Winchester syndrome Abnormalities of dermal fibrous and elastic tissue are caused by problems in the regulation of collagen ... Superficial lymphatic malformation (lymphangioma circumscriptum) Supernumerary nipple (accessory nipple, pseudomamma) ...
George Whipple
One of his first publications described the role of the lungs, lymphatic system, and gastrointestinal tract in the spread of ... He named this abnormality lipodystrophia intestinalis (intestinal lipodystrophy), and correctly pointed to the bacterial cause ...
Brugia malayi
B. malayi is one of the causative agents of lymphatic filariasis, a condition marked by infection and swelling of the lymphatic ... Tetracyclines have been shown to cause reproductive and embryogenesis abnormalities in the adult worms, resulting in worm ... Promoting hygiene is essential for lymphatic filariasis patients given the compromised immune and damaged lymphatic systems and ... The World Health Organization's Global Program to Eliminate Lymphatic Filariasis The Global Alliance to Eliminate Lymphatic ...
Fontan procedure
Abnormalities including chronic kidney disease and impaired renal function have been shown with measured renal function. ... Chronic venous hypertension from the stasis and lowered cardiac output are assumed to be at the root of lymphatic complications ... New interventional and surgical strategies have been investigated to relieve the lymphatic complications associated with the ... New approaches to the management of failing Fontans or other clinical deterioration have included lymphatic decompression ...
Milroy's disease
... caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid ... FLT4 codes for VEGFR-3, which is implicated in development of the lymphatic system. Milroy's disease is also known as primary ... Rockson SG (October 2010). "Causes and consequences of lymphatic disease". Annals of the New York Academy of Sciences. 1207 ... May have similar health conditions, delays, disorders, and physical traits associated with other lymphatic genetic diseases and ...
Nuchal scan
... to detect chromosomal abnormalities in a fetus, though altered extracellular matrix composition and limited lymphatic drainage ... Since chromosomal abnormalities can result in impaired cardiovascular development, a nuchal translucency scan is used as a ... The buildup in fluid is due to a blockage of fluid in the developing fetal lymphatic system. Progressive increase in the width ... Until recently, the only reliable ways to determine if the fetus has a chromosomal abnormality was to have an invasive test ...
Phlebology
Lymphatic Medicine uses a certification exam based on ABMS standards. The American Vein and Lymphatic Society (AVLS), formerly ... from varicose veins to congenital abnormalities to deep vein thrombosis to chronic venous diseases. Founded in 1987, the AVF ... lymphatics disorders and venous embryology. The American Board of Venous and Lymphatic Medicine results in certification as a " ... In 2007 the American Board of Phlebology (ABPh), subsequently known as the American Board of Venous & Lymphatic Medicine (ABVLM ...
Duck circovirus
The clinical signs are immunosuppression, stunting in growth, and also feather abnormalities. The PCR and dot blot ... with DuCV appears to cause growth disorders in ducks as well as eventual immunosuppression due to depletion of lymphatic cells ...
Anatomy of the human heart
Other abnormalities are coronary arteries originating from a not typical sinus and then traveling either between the Aorta and ... There are three distinct lymphatic drainage plexuses in the heart; after anastomosing each other, they end up in a ... Among that 1%, the most common abnormality is Circumflex arising from Right Coronary artery, instead of Left Main Artery and ...
Seckeler | NON-CONTRAST MR LYMPHOGRAPHY OF RARE LYMPHATIC ABNORMALITIES | Lymphology
Two control subjects and five affected patients (decompensated Fontan circulation, central conducting lymphatic abnormality, ... NON-CONTRAST MR LYMPHOGRAPHY OF RARE LYMPHATIC ABNORMALITIES, Lymphology. 53(3) :136-140. doi: 10.2458/lymph.4665 ... NON-CONTRAST MR LYMPHOGRAPHY OF RARE LYMPHATIC ABNORMALITIES. Lymphology 53(3) :136-140. doi: 10.2458/lymph.4665 ... NON-CONTRAST MR LYMPHOGRAPHY OF RARE LYMPHATIC ABNORMALITIES. Lymphology. 2021 1; 53(3) :136-140. doi: 10.2458/lymph.4665 ...
Cystic hygroma: MedlinePlus Medical Encyclopedia
Abnormalities of lymphatic vessels. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook ... This material is called embryonic lymphatic tissue.. After birth, a cystic hygroma most often looks like a soft bulge under the ... The long-term outcome may also depend on what other chromosomal abnormalities or birth defects, if any, are present. ...
Lymphomas, Endocrine, Mesenchymal, and Other Rare Tumors of the Mediastinum: Background, Anatomy, Pathophysiology
Isolated cystic abnormalities of lymphatic origin, such as hygromas or lymphangiomas, can develop within the middle mediastinal ... It is most often discovered at (or shortly after) birth and is believed to result from a developmental lymphatic abnormality ... Lymphatic tumors. Several types of lymphomas can be found in the mediastinum. [2, 3] They may be found in the mediastinum as a ... The most common tumors and masses in the anterior compartment are of thymic, lymphatic, or germ cell origin. More rarely, the ...
Fibro-adipose vascular anomaly - Wikipedia
FAVA also causes venous and/or lymphatic abnormalities. Though FAVA has only been recognized as a distinct vascular anomaly, ... Organizing thrombi, lymphatic foci and enlarged nerves encircled by dense fibrous tissue are also frequently noted in FAVA.[ ... April 2015). "Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA". The ... April 2015). "Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA". The ...
Group G Streptococcal Bacteremia in Jerusalem - Volume 10, Number 8-August 2004 - Emerging Infectious Diseases journal - CDC
... it was related to lymphatic abnormalities. These abnormalities were mostly attributed to malignancy, surgery, or radiation. Two ... Five had lymphatic drainage abnormalities. Two patients had recurrent bacteremia attributable to the same emm type (stG840, ... Five patients had chronic lymphatic abnormalities at the infection site compared to 11 of 42 patients with nonrecurrent ... more likely to develop in patients with lymphatic drainage abnormalities when compared to patients without such abnormalities. ...
DailyMed - FOSPHENYTOIN SODIUM- fosphenytoin sodium injection
Laboratory Test Abnormality: Phenytoin or fosphenytoin sodium injection may decrease serum concentrations of T4. It may also ... Hematologic and Lymphatic: Infrequent: thrombocytopenia, anemia, leukocytosis, cyanosis, hypochromic anemia, leukopenia, ... Laboratory Test Abnormality: Phenytoin (the active metabolite of fosphenytoin sodium injection) may cause increased serum ... In addition, the fetal hydantoin syndrome, a pattern of abnormalities including dysmorphic skull and facial features, nail and ...
Advanced Search Results - Public Health Image Library(PHIL)
Obstructive Sleep Apnea in Children | AAFP
Vascular proliferations and abnormalities of blood vessels | DermNet
Vascular proliferations and abnormalities of blood vessels. Authoritative facts from DermNet New Zealand. ... Lymphatic malformation: lymphangioma circumscriptum, cavernous lymphangioma. *Angioma serpiginosa: a crop of swirling vascular ... Vascular proliferations and abnormalities of blood vessels. Author: A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand ... Acquired lymphangiectasia: "frog-spawn" appearance that follows lymphatic obstruction eg tumour or surgery. ...
Sperm Abnormalities - Gluten Free Works: TREATMENT GUIDE
System - Lymphatic (8) *System - Male Reproductive (6) *System - Muscle (3) *System - Nervous (32) ... Home / A LISTING OF ALL HEALTH CONDITIONS / Sperm Abnormalities Sperm Abnormalities Posted by: Cleo Libonati, RN, BSN in A ... What Are Sperm Abnormalities?. Sperm abnormalities are the result of gonadal dysfunction (testicles) characterized by inability ... Health Conditions Low Sperm Count Malabsorption Malnutrition Omega-6 Fatty Acids Pregnancy and Birth Sperm Abnormalities ...
DailyMed - ETODOLAC tablet
Hemic and lymphatic system - Lymphadenopathy.. Nervous system - Anxiety, dream abnormalities, convulsions, coma, hallucinations ... These laboratory abnormalities may progress, may remain unchanged, or may be transient with continuing therapy. Notable ... Hemic and lymphatic system - Ecchymosis, anemia, thrombocytopenia, bleeding time increased, agranulocytosis, hemolytic anemia, ...
Diffuse large B cell lymphoma: Outlook, stages, treatment
Rescriptor: Package Insert - Drugs.com
Marked laboratory abnormalities are defined as any Grade 3 or 4 abnormality found in patients at any time during study. ... Hemic and Lymphatic System: Adenopathy, bruising, eosinophilia, granulocytosis, leukopenia, pancytopenia, purpura, spleen ... Laboratory Abnormalities:. Marked laboratory abnormalities observed in at least 2% of patients during Studies 21 Part II and ... Marked Laboratory Abnormalities Reported by ≥2% of Patients N/A = not applicable because no predose values were obtained for ...
Glatopa (glatiramer acetate Injection): Uses, Dosage, Side Effects, Interactions, Warning
Hemic and Lymphatic System: thrombocytopenia; lymphoma-like reaction; acute leukemia. Hepatobiliary Disorders: cholelithiasis; ... Urogenital System: urogenital neoplasm; urine abnormality; ovarian carcinoma; nephrosis; kidney failure; breast carcinoma; ... Hemic and Lymphatic. Infrequent: Leukopenia, anemia, cyanosis, eosinophilia, hematemesis, lymphedema, pancytopenia, and ... Some fraction of the injected material, either intact or partially hydrolyzed, is presumed to enter the lymphatic circulation, ...
USF1 | Cancer Genetics Web
Besides vascular and lymphatic endothelial cells, VEGFs affect multiple other cell types. Understanding VEGF biology and its ... arteriovenous malformations and placental abnormalities. In heart, VEGF gene transfer induces myocardial angiogenesis. ... Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation of VEGF signaling is connected to ...
Lupron, Eligard (leuprolide) dosing, indications, interactions, adverse effects, and more
Hemic and lymphatic system: Ecchymosis. *Laboratory abnormalities: Decreased albumin, decreased hemoglobin/hematocrit, ... Hemic and lymphatic system: anemia, lymphedema. *Laboratory abnormalities: Increased BUN, hyperglycemia, hyperlipidemia, ... Hemic and lymphatic system: Decreased WBC. *Central/peripheral nervous system: Convulsion, peripheral neuropathy, spinal ... frequent electrolyte abnormalities, and patients taking drugs known to prolong the QT interval; correct electrolyte ...
The Third Circulation: Radionuclide Lymphoscintigraphy in the Evaluation of Lymphedema | Journal of Nuclear Medicine
Lymphedema results from impaired lymphatic transport caused by injury to the lymphatics, infection, or congenital abnormality. ... The lymphatic vasculature consists of initial lymphatics, or lymphatic precollectors, which coalesce into lymphatic ducts, ... LYMPHATIC ANATOMY, PHYSIOLOGY, AND PATHOLOGY. Components of the Lymphatic System. The lymphatic system is a component of both ... A subclinical form of lymphatic insufficiency can exist when lymphatic transport reserve is diminished. Subclinical lymphatic ...
Dermatology | National University Hospital
Birthmark Support Group
Lymphedema Treatment, Symptoms, Causes & Therapy
Primary lymphedema is an abnormality of an individuals lymphatic system and is generally present at birth, although symptoms ... The lymphatic system is a network of specialized vessels (lymph vessels) throughout the body whose purpose is to collect excess ... Primary lymphedema is the result of an anatomical abnormality of the lymph vessels and is a rare, inherited condition. ... CT or MRI scans may be useful to help define lymph node architecture or to identify tumors or other abnormalities. ...
CT Findings of Granulomatous Pneumonitis Secondary to Mycobacterium avium-intracellulare Inhalation: "Hot Tub Lung" | AJR
Perilymphatic distribution indicated the presence of the abnormality along the lymphatic distribution and included the ... In one patient, air trapping was the only abnormality identified.. CONCLUSION. The CT findings in patients with hot tub lung ... Mycobacterium avium complex (MAC) is the most common of the pathogens and can cause several different patterns of abnormalities ... When any of these findings was present, the distribution of the abnormality was noted both in the cephalocaudal plane (upper, ...
Noonan Syndrome
22q11 Deletion Syndrome | Harvard Catalyst Profiles | Harvard Catalyst
Lymphatic Abnormalities [C16.131.482]. *22q11 Deletion Syndrome [C16.131.482.249]. *Musculoskeletal Abnormalities [C16.131.621] ... White matter microstructural abnormalities of the cingulum bundle in youths with 22q11.2 deletion syndrome: associations with ... Abnormalities in gray matter microstructure in young adults with 22q11.2 deletion syndrome. Neuroimage Clin. 2019; 21:101611. ... Neurocristopathies: Enigmatic Appearances of Neural Crest Cell-derived Abnormalities. Radiographics. 2019 Nov-Dec; 39(7):2085- ...
Lymphedema Care | Ochsner Health
Cardiac Sarcoidosis - Cardiovascular Disorders - Merck Manuals Professional Edition
The lungs and lymphatic system are most often affected, but... read more is reviewed elsewhere in THE MANUAL. This topic ... If cardiac symptoms, signs, or test abnormalities are present, cardiac MRI with gadolinium should also be done, and also ... The lungs and lymphatic system are most often affected, but... read more itself are given, including corticosteroids and ... Most commonly, the diagnosis is established by extracardiac biopsy in conjunction with suggestive cardiac abnormalities on ...
Deadly scrub typhus bacteria confirmed in South America | University of Oxford
Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease | Thorax
... it is tempting to speculate that this pattern may be related to interstitial oedema and/or increased lymphatic drainage. ... had lung function abnormalities: 8 (23%) had a restrictive abnormality, 6 (17%) an obstructive abnormality, 4 (11%) a mixed ... HRCT abnormalities. A reticular pattern on HRCT was the most prevalent and extensive abnormality, seen in 26 patients (median 5 ... Conclusions Abnormalities in pulmonary vascular volumes may explain some of the lung function abnormalities and the decline in ...
Research Labs and Institutes | Johns Hopkins Medicine
VesselsMalformationHemicCongenitalChronic lymphaticDiseasesLymphedemaCraniofacial abnormalitiesTissuesSpleenSystemCapillaryNodulesCoagulationMalignancyLymphocytesChromosomalFluidUptakeEctasiaPatientsPulmonaryDrainageVenous channelsExtremitiesClinicalAbnormalSyndromesDysfunctionNeckPresentDiagnosisNeoplasticBloodDiseaseSecondaryFunctionPossibly
Vessels19
- Abnormalities of lymphatic vessels. (medlineplus.gov)
- The lymphatic system is a network of specialized vessels (lymph vessels) throughout the body whose purpose is to collect excess lymph fluid with proteins, lipids , and waste products from the tissues. (medicinenet.com)
- Primary lymphedema is the result of an anatomical abnormality of the lymph vessels and is a rare, inherited condition. (medicinenet.com)
- Congenital or acquired structural abnormalities of the lymphatic system ( LYMPHOID TISSUE ) including the lymph vessels. (nih.gov)
- He is particularly interested in novel MRI approaches to image small blood and lymphatic vessels in the brain. (hopkinsmedicine.org)
- According to Felix's vet, the four glands are connected to lymphatic vessels that can transport cancer cells through the body, so doing a radical mastectomy is the best way to be sure you cut out the problem. (smithsonianmag.com)
- Lymphatic malformations are fluid filled channels or vessels where the lymphatic system has not developed properly, causing dilated vessels and clear fluid accumulation as a result of the slow flowing lymph. (k-t.org)
- Blood vessels originating from lymphatic vessels were found to be tailored to specific functions. (israelnationalnews.com)
- In the new study, postdoctoral fellow Dr. Rudra N. Das, working in Yaniv's lab in the Immunology and Regenerative Biology Department, discovered that blood vessels can develop from a previously unknown source: lymphatic vessels. (israelnationalnews.com)
- It was known that blood vessels can give rise to lymphatic vessels, but we've shown for the first time that the reverse process can also take place in the course of normal development and growth," Das says. (israelnationalnews.com)
- By tracing the growth of fins on the body of a juvenile zebrafish, Das saw that even before the bones had formed, the first structures to emerge in a fin were lymphatic vessels. (israelnationalnews.com)
- Das and colleagues provided an explanation by analyzing mutant zebrafish that lacked lymphatic vessels. (israelnationalnews.com)
- They found that when lymphatic vessels were absent, the blood vessels did sprout in the growing fins of these mutants by branching from existing, nearby blood vessels. (israelnationalnews.com)
- A comparison revealed that in the mutant fish, excessive numbers of red blood cells entered the newly-formed blood vessels in the fins, whereas in regular fish with lymphatic-derived blood vessels, this entry was controlled and restricted. (israelnationalnews.com)
- In other words, only those blood vessels that had matured from lymphatic vessels were perfectly suited to their specialized function - in this case, proper fin development. (israelnationalnews.com)
- They saw that the entire process they had observed during the fins' development repeated itself during its regeneration - namely, lymphatic vessels grew first, and only later did they transform into blood vessels. (israelnationalnews.com)
- Diagnosis of intestinal lymphangiectasia usually requires endoscopic small-bowel biopsy, which shows marked dilation and ectasia of the mucosal and submucosal lymphatic vessels at the tips of the villi. (msdmanuals.com)
- anaplastic carcinoma of the mammary gland is considered a highly invasive and malignant neoplasia, which usually leads to neoplastic thrombosis and epidermal ulceration due to invasiveness of lymphatic vessels by tumor emboli. (ufrgs.br)
- In this study, two causes which may have led to thromboembolism and cerebral hemorrhage are discussed: septicemia after invasion of lymphatic vessels by the anaplastic carcinoma or hypercoagulability caused by the systemic neoplasia, which could have reduce the blood flow to vessels of the cerebral cortex. (ufrgs.br)
Malformation11
- The extrafascial part is composed of fatty overgrowth, phlebectasia, and occasional lymphatic malformation. (wikipedia.org)
- Simple vascular malformations are further divided into slow-flow (venous, lymphatic, and capillary malformation) and fast-flow malformations (arteriovenous malformation and arteriovenous fistula). (medscape.com)
- A combined vascular malformation involves two or more types of vessel abnormalities. (birthmarksupportgroup.org.uk)
- Keeping the area of the lymphatic malformation clean is also extremely important as it reduces the risk of skin breakdown and infection, particularly for lesions involving the feet and legs. (k-t.org)
- Sudden enlargement of a lymphatic malformation is likely the result of bleeding or an infection (cellulitis). (k-t.org)
- If there is an infection involving an area that contains a lymphatic malformation, antibiotic therapy must be initiated. (k-t.org)
- Cellulitis can be differentiated from bleeding most often by symptoms of redness and heat over the lymphatic malformation. (k-t.org)
- Bleeding into a lymphatic malformation can be painful and should also be seen by a physician. (k-t.org)
- Therefore, it is reasonable to consider that any malformation in the venous anatomy would carry over to the development of the lymphatic system. (veindirectory.org)
- Intestinal lymphangiectasia is a rare disorder characterized by obstruction or malformation of the intramucosal lymphatics of the small bowel. (msdmanuals.com)
- Malformation of the lymphatic system is congenital or acquired. (msdmanuals.com)
Hemic2
- body['s] ... hemic and lymphatic [systems]. (justia.com)
- Thus, HIV infection must be regarded as a physiological disorder with an immediate, constant, and detrimental effect on the hemic and lymphatic systems. (justia.com)
Congenital3
- Lymphedema results from impaired lymphatic transport caused by injury to the lymphatics, infection, or congenital abnormality. (snmjournals.org)
- Primary lymphedema is caused by a developmental abnormality of the lymphatic system, which is either congenital or hereditary. (ochsner.org)
- Schinzel-Giedion syndrome is a highly recognizable syndrome characterized by severe mental retardation, distinctive facial features, and multiple congenital malformations including skeletal abnormalities, genitourinary and renal malformations, and cardiac defects, as well as a higher-than-normal prevalence of tumors, notably neuroepithelial neoplasia (summary by Hoischen et al. (beds.ac.uk)
Chronic lymphatic2
- Six patients had recurrent bacteremia with two to four bacteremic episodes, five had chronic lymphatic disorders, and two had emm type stG 840.0 in every episode. (cdc.gov)
- Lymphedema-edema that results from chronic lymphatic insufficiency-is a chronic debilitating disease that is frequently misdiagnosed, treated too late, or not treated at all. (snmjournals.org)
Diseases1
- Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
Lymphedema8
- A combination of conservative surgery and careful patient selection for nodal radiotherapy may reduce the incidence of postmastectomy lymphedema ( 8 ), particularly when these therapies are combined with sentinel node biopsy, but their impact on the incidence of postsurgical lymphatic insufficiency has not yet been adequately assessed. (snmjournals.org)
- Lymphedema is the impaired flow of the lymphatic system that causes swollen extremities. (medicinenet.com)
- Lymphedema is swelling in one or more extremities that results from impaired flow of the lymphatic system. (medicinenet.com)
- Primary lymphedema is an abnormality of an individual's lymphatic system and is generally present at birth, although symptoms may not become apparent until later in life. (medicinenet.com)
- Secondary lymphedema develops when a normally-functioning lymphatic system is blocked or damaged. (medicinenet.com)
- To understand lymphatic malformations and lymphedema, let's look at the lymphatic system. (k-t.org)
- When many think of lymphedema, they consider the hereditary nature of lymphedema and reflect on the patient who either presents with chronic edema in their prepubescent period or post-cancer patients whose lymph node removal or radiation treatment has ablated their lymphatics. (veindirectory.org)
- We have also recognized that hereditary lymphatic disease may remain dormant, with patients predisposed to lymphedema frequently reporting their first symptoms not until their 50s or 60s. (veindirectory.org)
Craniofacial abnormalities1
- OSA often results from adenotonsillar hypertrophy, neuromuscular disease, and craniofacial abnormalities. (aafp.org)
Tissues3
- Briefly, there can be cold agglutinins, which are antibodies produced by such diverse conditions like infections with mononucleosis, in a patient with mycoplasma pneumonia or in association with certain abnormalities in the lymphatic tissues. (nethealthbook.com)
- Lymphocytes are stored within lymph nodes and may also be found in other lymphatic tissues. (rarediseases.org)
- Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
Spleen3
- The tonsils, adenoids, spleen and thymus are all part of the lymphatic system. (k-t.org)
- In addition to the lymph nodes, the lymphatic system includes the spleen. (rarediseases.org)
- Diagnostic imaging of abnormalities in the number and location of the spleen. (beds.ac.uk)
System16
- These abnormal cells quickly proliferate in the lymphatic system, causing complications. (medicalnewstoday.com)
- The DLBCL has spread to organs outside the lymphatic system, such as the lungs or bones. (medicalnewstoday.com)
- The DLBCL has spread beyond the lymphatic system. (medicalnewstoday.com)
- In addition to reviewing the anatomy and physiology of the lymphatic system, we review physiologic principles of lymphatic imaging with lymphoscintigraphy, discuss different qualitative and quantitative lymphoscintigraphic techniques and their clinical applications, and present clinical cases depicting typical lymphoscintigraphic findings. (snmjournals.org)
- How Does the Lymphatic System Work? (k-t.org)
- The lymphatic system is a part of the circulatory system, and a vital part of the immune system. (k-t.org)
- The lymphatic system is made up of vascular channels that are only visible on certain scans. (k-t.org)
- However, many conditions can lead to the development of a pleural effusion, including genetic or chromosomal disorders, abnormalities of the heart structure or rhythm, masses that occupy space in the chest, infections, or abnormal function of the lymphatic system. (mottchildren.org)
- Because carbohydrates are not absorbed through the lymphatic system, their uptake is not impaired. (msdmanuals.com)
- What is lymphatic system and how is it related to lymphoma? (medifee.com)
- To have a better understanding of lymphoma, a basic understanding of the workings of the lymphatic system is vital. (medifee.com)
- A clear fluid that is circulated by the lymphatic system. (medifee.com)
- Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
- Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. (rarediseases.org)
- As lymph moves through the lymphatic system, it is filtered by a network of small structures known as lymph nodes that help to remove microorganisms (e.g., viruses, bacteria, etc.) and other foreign bodies. (rarediseases.org)
- Competing theories include the partial persistence of an embryologic vascular system, mesodermal developmental abnormalities, and venous hypertension as a result of vascular agenesis, atresia, or hypoplasia possibly related to compression of the deep venous system by abnormal muscles or fibrovascular cords. (mhmedical.com)
Capillary1
- Any of the four types of vascular birthmarks (capillary, lymphatic, venous or arteriovenous) may be combined. (birthmarksupportgroup.org.uk)
Nodules1
- The CT images were reviewed by two thoracic radiologists who assessed the images for the presence of any parenchymal abnormalities, including nodules, areas of ground-glass attenuation, reticular opacities, and air trapping, on expiratory images. (ajronline.org)
Coagulation2
- Other findings can include broad or webbed neck, unusual chest shape with superior pectus carinatum and inferior pectus excavatum, cryptorchidism, varied coagulation defects, lymphatic dysplasias, and ocular abnormalities. (nih.gov)
- None of the patients had coagulation abnormalities. (elsevierpure.com)
Malignancy1
- Oedema of the upper limb may be attributable to several factors, including malignancy, venous or lymphatic abnormality. (woundsinternational.com)
Lymphocytes3
- In DLBCL, abnormalities within the B cell lymphocytes mean the cells no longer develop and function as they should. (medicalnewstoday.com)
- Lymphocyte: Lymphatic tissue is mainly made up of lymphocytes, a form of White Blood Cell(WBC). (medifee.com)
- Lymphatic tissue or circulating lymphocytes may also be located in other regions of the body, such as the skin, small intestine, liver, and other organs. (rarediseases.org)
Chromosomal1
- The long-term outcome may also depend on what other chromosomal abnormalities or birth defects, if any, are present. (medlineplus.gov)
Fluid2
- Scrub typhus, caused by the bacteria, Orientia tsutsugamushi , is transmitted through the bite of an infective mite, and spreads through the lymphatic fluid and blood, causing fever, rash, and laboratory abnormalities such as elevated levels of C-reactive protein and liver enzymes. (ox.ac.uk)
- Lymphatic malformations can have tiny fluid spaces (microcystic) or large fluid spaces (macrocystic), or they can be a combination of both. (k-t.org)
Uptake1
- The new, widely-accepted view is that lymphatics are responsible for the majority of the lymphatic uptake in the management of lymphatic overload. (veindirectory.org)
Ectasia2
- Thick and hyaline collagen fibers are found, as well as lymphatic ectasia and pilosebaceous atrophy that extends to the hypodermic region (Fig. 2). (cdlib.org)
- The apparently normal skin from the patient with scleroderma shows histological signs of the disease, with thick collagen fibers and lymphatic ectasia. (cdlib.org)
Patients6
- Objectives To test the hypothesis that vascular abnormalities on high-resolution CT (HRCT) would be associated with echocardiographic changes and lung function abnormalities in patients with sickle cell disease (SCD) and the decline in lung function seen in SCD patients. (bmj.com)
- Vascular abnormalities on high-resolution CT (HRCT) would be associated with echocardiographic changes and lung function abnormalities in patients with sickle cell disease (SCD) and with the decline in lung function seen in SCD patients. (bmj.com)
- Alterations in pulmonary vascular volumes due to anaemia in SCD patients may be responsible for some of their lung function abnormalities and changes seen on HRCT and their decline in lung function. (bmj.com)
- In this small cohort, the BG iron deposition in MS patients does not seem to be correlated with flow abnormalities in the veins of the neck. (cnr.it)
- Patients apparently are of average intelligence, and no associated mental or psychiatric abnormalities seem to be present. (medscape.com)
- An elevated arterial or free venous serum ammonia level is the classic laboratory abnormality reported in patients with hepatic encephalopathy. (medscape.com)
Pulmonary2
- Conclusions Abnormalities in pulmonary vascular volumes may explain some of the lung function abnormalities and the decline in lung function seen in adults with SCD. (bmj.com)
- This book for clinicians shows and describes examples of radiographic abnormalities common in pediatric tuberculosis, emphasizing pulmonary, lymphatic and meningeal disease. (cdc.gov)
Drainage5
- Impaired lymphatic drainage leads to increased pressure and leakage of lymph into the intestinal lumen. (msdmanuals.com)
- Aim We sought to evaluate the postoperative recipient lymphatic drainage depending on open donor nephrectomy (ODN) or laparoscopic (LDN) techniques. (elsevierpure.com)
- Both cranial and caudal drainage catheters for lymphatic leakage were placed preoperatively and all the recipients received tacrolimus, mycophenolate mofetil, and steroid as immunosuppressive regimen. (elsevierpure.com)
- Conclusions There seems to be no difference in recipient lymphatic drainage by donor nephrectomy technique. (elsevierpure.com)
- A laparoscopic procedure may be advantageous owing to shorter lymphatic drainage during clinical acute rejection episodes. (elsevierpure.com)
Venous channels1
- Intestinal resection or anastomosis of the abnormal lymphatics to the venous channels may be beneficial. (msdmanuals.com)
Extremities1
- Your physician might recommend compression garments to control filling of dilated lymphatic channels and swelling of extremities. (k-t.org)
Clinical1
- If an abnormality is identified by a breast self-exam, clinical exam or on a screening mammogram, diagnostic tests will be performed to identify if breast cancer is present. (memorialhealth.com)
Abnormal2
- Alternatively, contrast lymphangiography (injection of contrast material via the pedal lymphatics) can show abnormal intestinal lymphatics. (msdmanuals.com)
- Abnormal lymphatics cannot be corrected. (msdmanuals.com)
Syndromes1
- It encompasses several syndromes with overlapping abnormalities including the DIGEORGE SYNDROME, VELOCARDIOFACIAL SYNDROME, and CONOTRUNCAL AMOMALY FACE SYNDROME. (harvard.edu)
Dysfunction3
- S perm abnormalities are the result of gonadal dysfunction (testicles) characterized by inability to either produce sperm or to produce viable sperm or mobile sperm which results in prohibiting fertilization of the female ovum. (glutenfreeworks.com)
- This paradigm shift further necessitates new technology to optimally assess and possibly treat lymphatic dysfunction. (veindirectory.org)
- As noted previously, lymphatic overload has two primary presentations: lymphatic overload and lymphatic dysfunction. (veindirectory.org)
Neck1
- Axial T2-weighted MRI shows an extensive soft-tissue abnormality involving the neck, face, and oropharyngeal structures. (medscape.com)
Present1
- Lymphatic abnormalities can often be present and range from hypoplasia to aplasia. (mhmedical.com)
Diagnosis2
- Radiography, ultrasonography (US), CT, or MRI is usually performed to confirm the suspected diagnosis, to determine the extent of the vascular anomaly, and to search for associated abnormalities. (medscape.com)
- Finding an abnormality does not automatically result in a breast cancer diagnosis. (memorialhealth.com)
Neoplastic1
- In acquired cases, the defect may be secondary to retroperitoneal fibrosis, constrictive pericarditis, pancreatitis, neoplastic tumors, and infiltrative disorders that block the lymphatics. (msdmanuals.com)
Blood2
- It causes immediate abnormalities in a person's blood, and the infected person's white cell count continues to drop throughout the course of the disease, even during the intermediate stage when its attack is concentrated in the lymph nodes. (justia.com)
- In the mutant fish, on the other hand, an excess of red blood cells disrupted these conditions, which could well explain the observed abnormalities. (israelnationalnews.com)
Disease2
- What Are Sperm Abnormalities In Celiac Disease and/or Gluten Sensitivity? (glutenfreeworks.com)
- Lyme disease antibodies (IgM and IgG) were negative and chest x-ray and upper endoscopy do not show abnormalities. (cdlib.org)
Secondary1
- These bone abnormalities are usually asymmetric and cause secondary fractures. (medscape.com)
Function1
- The hemogram, thyroid, and kidney-function exams do not reveal abnormalities. (cdlib.org)
Possibly1
- We describe an entity of recurrent GGS bacteremia, which is associated with lymphatic disorders and possibly with emm stG 840.0. (cdc.gov)
