Lymphatic Vessel Tumors
Neoplasms, Vascular Tissue
Endothelium, Lymphatic
Vascular Endothelial Growth Factor Receptor-3
Lymphography
Vascular Endothelial Growth Factor C
Synchronous multifocal osteosarcoma with lymphatic spread in the lung: an autopsy case report. (1/3)
Synchronous multifocal/multicentric osteosarcoma (MOS) is a rare variant of osteosarcoma. We report here an autopsy case of a 15-year-old boy with MOS. Radiological examinations showed multiple sclerotic lesions in the left distal femur and in the ipsilateral proximal tibia without pulmonary metastasis at the first examination. Histological examination showed osteoblastic-type osteosarcoma. Despite high-dose chemotherapy the patient died of multiple bone and lung involvements 6 months after the initial diagnosis. Autopsy examination revealed prominent invasion of the tumor cells into lymphatic vessels and pleural dissemination without the formation of bulky, nodular metastasis in the lungs. Metastases in pulmonary hilar lymph nodes were noted without metastasis in other organs. Immunohistochemistry revealed that p53 protein was positive in most of the tumor cells. In summary, the present case was characterized by multiple bone involvement and prominent lymphatic spread of sarcoma cells in the lungs. (+info)Increased vascular endothelial growth factor-C expression is insufficient to induce lymphatic metastasis in human soft-tissue sarcomas. (2/3)
(+info)Head and neck lymphatic tumors and bony abnormalities: a clinical and molecular review. (3/3)
(+info)Lymphatic vessel tumors, also known as lymphangiomas, are benign (non-cancerous) tumors that develop from the lymphatic vessels. These tumors are made up of abnormal masses of dilated lymphatic vessels and can occur anywhere in the body, but they most commonly affect the head, neck, and axilla (armpit).
Lymphangiomas can be classified into three types based on their size and depth:
1. Capillary lymphangioma: This is a superficial type of lymphangioma that affects the skin and mucous membranes. It appears as a cluster of small, thin-walled vessels that are filled with clear fluid.
2. Cavernous lymphangioma: This is a deeper type of lymphangioma that affects the subcutaneous tissue. It appears as a mass of dilated lymphatic vessels that are filled with clear or milky fluid.
3. Cystic hygroma: This is a large, sac-like lymphangioma that affects the neck and armpit regions. It contains multiple cysts filled with clear or milky fluid.
Lymphangiomas are usually present at birth or develop during childhood. They may cause symptoms such as swelling, pain, infection, and difficulty swallowing or breathing if they affect the head and neck region. Treatment options for lymphatic vessel tumors include surgical excision, sclerotherapy (injection of a chemical agent to shrink the vessels), and laser therapy.
A neoplasm of vascular tissue is an abnormal growth or mass of cells in the blood vessels or lymphatic vessels. These growths can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms, such as hemangiomas and lymphangiomas, are typically not harmful and may not require treatment. However, they can cause symptoms if they grow large enough to press on nearby organs or tissues. Malignant neoplasms, such as angiosarcomas, are cancerous and can invade and destroy surrounding tissue, as well as spread (metastasize) to other parts of the body. Treatment for vascular tissue neoplasms depends on the type, size, location, and stage of the growth, and may include surgery, radiation therapy, chemotherapy, or a combination of these.
Lymphatic vessels are thin-walled, valved structures that collect and transport lymph, a fluid derived from the interstitial fluid surrounding the cells, throughout the lymphatic system. They play a crucial role in immune function and maintaining fluid balance in the body. The primary function of lymphatic vessels is to return excess interstitial fluid, proteins, waste products, and immune cells to the bloodstream via the subclavian veins near the heart.
There are two types of lymphatic vessels:
1. Lymphatic capillaries: These are the smallest lymphatic vessels, found in most body tissues except for the central nervous system (CNS). They have blind ends and are highly permeable to allow the entry of interstitial fluid, proteins, and other large molecules.
2. Larger lymphatic vessels: These include precollecting vessels, collecting vessels, and lymphatic trunks. Precollecting vessels have valves that prevent backflow of lymph and merge to form larger collecting vessels. Collecting vessels contain smooth muscle in their walls, which helps to propel the lymph forward. They also have valves at regular intervals to ensure unidirectional flow towards the heart. Lymphatic trunks are large vessels that collect lymph from various regions of the body and eventually drain into the two main lymphatic ducts: the thoracic duct and the right lymphatic duct.
Overall, lymphatic vessels play a vital role in maintaining fluid balance, immune surveillance, and waste removal in the human body.
The lymphatic system is a complex network of organs, tissues, vessels, and cells that work together to defend the body against infectious diseases and also play a crucial role in the immune system. It is made up of:
1. Lymphoid Organs: These include the spleen, thymus, lymph nodes, tonsils, adenoids, and Peyer's patches (in the intestines). They produce and mature immune cells.
2. Lymphatic Vessels: These are thin tubes that carry clear fluid called lymph towards the heart.
3. Lymph: This is a clear-to-white fluid that contains white blood cells, mainly lymphocytes, which help fight infections.
4. Other tissues and cells: These include bone marrow where immune cells are produced, and lymphocytes (T cells and B cells) which are types of white blood cells that help protect the body from infection and disease.
The primary function of the lymphatic system is to transport lymph throughout the body, collecting waste products, bacteria, viruses, and other foreign substances from the tissues, and filtering them out through the lymph nodes. The lymphatic system also helps in the absorption of fats and fat-soluble vitamins from food in the digestive tract.
Lymphangiogenesis is the formation of new lymphatic vessels from pre-existing ones. It is a complex biological process that involves the growth, differentiation, and remodeling of lymphatic endothelial cells, which line the interior surface of lymphatic vessels. Lymphangiogenesis plays crucial roles in various physiological processes, including tissue drainage, immune surveillance, and lipid absorption. However, it can also contribute to pathological conditions such as cancer metastasis, inflammation, and fibrosis when it is dysregulated.
The process of lymphangiogenesis is regulated by a variety of growth factors, receptors, and signaling molecules, including vascular endothelial growth factor (VEGF)-C, VEGF-D, and their receptor VEGFR-3, as well as other factors such as angiopoietins, integrins, and matrix metalloproteinases. Understanding the mechanisms of lymphangiogenesis has important implications for developing novel therapies for a range of diseases associated with abnormal lymphatic vessel growth and function.
The endothelium is a thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels. The lymphatic endothelium, specifically, is the type of endothelial cell that forms the walls of lymphatic vessels. These vessels are an important part of the immune system and play a crucial role in transporting fluid, waste products, and immune cells throughout the body.
The lymphatic endothelium helps to regulate the movement of fluids and cells between the tissues and the bloodstream. It also contains specialized structures called valves that help to ensure the unidirectional flow of lymph fluid towards the heart. Dysfunction of the lymphatic endothelium has been implicated in a variety of diseases, including lymphedema, inflammation, and cancer metastasis.
Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) is a type of receptor tyrosine kinase that is primarily expressed in lymphatic endothelial cells. It is a crucial regulator of lymphangiogenesis, which is the formation of new lymphatic vessels from pre-existing ones. VEGFR-3 binds to its ligands, including VEGF-C and VEGF-D, leading to the activation of downstream signaling pathways that promote cell survival, proliferation, migration, and differentiation of lymphatic endothelial cells.
VEGFR-3 also plays a role in angiogenesis, which is the formation of new blood vessels from pre-existing ones. However, its functions in angiogenesis are less well understood compared to its roles in lymphangiogenesis. Dysregulation of VEGFR-3 signaling has been implicated in various pathological conditions, including cancer, inflammation, and lymphatic disorders.
Lymphography is not a commonly used term in current medical practice. However, historically, it referred to a radiographic imaging technique that involved the injection of a contrast material into the lymphatic system to visualize the lymph nodes and lymph vessels. This procedure was used primarily for diagnostic purposes, particularly in the evaluation of cancerous conditions like lymphoma or melanoma.
The process typically involved injecting a radiopaque substance into the interstitial tissue, which would then be taken up by the lymphatic vessels and transported to the regional lymph nodes. X-ray imaging was used to track the progression of the contrast material, creating detailed images of the lymphatic system.
Due to advancements in medical imaging technology, lymphography has largely been replaced by other non-invasive imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. These modern methods provide high-resolution images of the body's internal structures without requiring invasive procedures or the use of contrast materials.
Vascular Endothelial Growth Factor C (VEGF-C) is a protein that belongs to the family of vascular endothelial growth factors. It plays a crucial role in angiogenesis, which is the formation of new blood vessels from pre-existing ones. Specifically, VEGF-C is a key regulator of lymphangiogenesis, which is the development of new lymphatic vessels.
VEGF-C stimulates the growth and proliferation of lymphatic endothelial cells, leading to an increase in the number and size of lymphatic vessels. This process is important for maintaining fluid balance in tissues and for the immune system's response to infection and inflammation.
Abnormal regulation of VEGF-C has been implicated in various diseases, including cancer, where it can promote tumor growth and metastasis by enhancing the formation of new blood vessels that supply nutrients and oxygen to the tumor. Inhibitors of VEGF-C have been developed as potential therapeutic agents for cancer treatment.
Anaplastic thyroid cancer
Proteus syndrome
Ovarian germ cell tumors
Lymph node stromal cell
Lymphangiomatosis
Targeted drug delivery
Mastocytoma in dogs
Tumor microenvironment
Lymphangioleiomyomatosis
Trematoda in Kuwait
Epithelioid hemangioendothelioma
Fibroma
Angioma
Peter Koopman
Tonsil carcinoma
Photothermal therapy
Undifferentiated pleomorphic sarcoma
Intravasation
Differential vascular labeling
Cisterna chyli
PDPN
Sirolimus
Lymphangioma
Porocarcinoma
MMP2
Brain tumor
C-fos-induced growth factor
Alveolar hydatid disease
Orofacial granulomatosis
List of MeSH codes (A15)
Lymphatic Vessel Tumors | VCA Animal Hospitals
Gene therapy method targets tumor blood vessels
Dormant tumour cells, their niches and the influence of immunity | Nature Cell Biology
Putting up a good fight: Regenerating the body's natural defenses by restoring lymphatic networks | ScienceDaily
Radiation-induced tumor immune microenvironments and potential targets for combination therapy | Signal Transduction and...
Anaplastic thyroid cancer - Wikipedia
Targetoid Hemosiderotic Hemangioma: Practice Essentials, Pathophysiology, Etiology
Lymphangioma, Cystic | Harvard Catalyst Profiles | Harvard Catalyst
Ryouichi Tomita - Articles - Scientific Research Publishing
JCI - Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis
JCI - Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats | Protocol
PDF) Management und Therapie des kolorektalen Frühkarzinoms
Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Incurable Stage IV Colorectal Cancer
Lymphedema (PDQ®) (Health professionals) | OncoLink
Journal Club 2022-23 | Immunology | Stanford Medicine
Dermatology | National University Hospital
Diane R. Bielenberg, PhD - DF/HCC
CNV-Adjusted Analysis Points to Prognostically Informative Meningioma Methylation Groups | GenomeWeb
Amgen Highlights Data To Be Presented At 2013 European Cancer Congress| Amgen
Mast Cell Tumors in Canines & Felines - What You Need to Know - The Honest Kitchen
Cancer: Sarcoma, Carcinoma, Lymphoma, and Leukemia
Ciliary Body Melanoma: Overview, Pathophysiology, Etiology
Krukenberg tumor | Radiology Reference Article | Radiopaedia.org
Breast Cancer : Medical Animation
Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen | Discover Nano
High Expression of Plakoglobin Promotes Metastasis in Invasive Micropapillary Carcinoma of the Breast via Tumor Cluster...
Video: 5 Value Full-Suspension Bikes Ridden & Rated - Field Test Roundtable by mikekazimer - Pinkbike
MD2B - Introduction to Oncology - Diagnostic Evaluation, Classification, and Staging | OncoLink
Metastasis24
- They are also defined as penile intraepithelial neoplasia, whereas the abbreviation Tis is used in the tumor-node-metastasis (TNM) classification. (medscape.com)
- Together these results indicate that SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells and raise the possibility of SEMA3F having therapeutic potential. (harvard.edu)
- The angiopoietins are also involved in lymphangiogenesis, the formation of new lymphatic vessels, which plays a key role in tumor metastasis. (amgen.com)
- Cancers continue to grow and spread by direct extension or through a process called metastasis, whereby the malignant cells travel through the lymphatic or blood vessels -- eventually forming new tumors in other parts of the body. (webmd.com)
- Primary treatment for breast cancer depends on the size of the tumor, lymph node involvement, and metastasis. (smartimagebase.com)
- In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
- Sertoli cell tumors and seminomas rarely exhibit regional or distant metastasis, though local invasion is common. (acvr.org)
- It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
- Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
- Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
- During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
- Tumour Angiogenesis and Metastasis-Correlation in Invasive Breast Carcinoma," The New England Journal of Medicine, Vol. 324, No. 1, 1991, pp. 1-8. (scirp.org)
- Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
- Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system. (ki.se)
- Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis. (ki.se)
- By doing so, EVT801 is expected to starve the tumour of vital nutrients and to reduce metastasis. (checkorphan.org)
- Metastasis is a pathological process by which tumor cells acquire the ability to leave the primary tumor, to migrate through the blood and lymphatic vessels, and eventually to reach secondary organs. (ircm.qc.ca)
- Using intravital microscopy, we have investigated the individual steps of lymphatic metastasis. (harvard.edu)
- Our studies have shown that VEGF -C, which is associated with lymphatic metastasis in patients, increases the size of the tumor margin lymphatic vessels, making them more vulnerable to invasion. (harvard.edu)
- Our data suggests that VEGF -C needs to be blocked very early in the metastatic process to be able to reduce VEGF -C enhanced lymphatic metastasis. (harvard.edu)
- To further study the growth of metastasis in the lymph node, we have developed a novel model that allows chronic imaging of a tumor draining lymph node. (harvard.edu)
- Using our model, we will ask fundamental questions underlying the growth of cancer cells in the lymph node and begin to identify molecular targets for future therapies aimed at eradicating lymphatic metastasis. (harvard.edu)
- Our future studies will continue to dissect the physical and molecular determinants of lymphatic vessel function, lymphangiogenesis and lymphatic metastasis. (harvard.edu)
- Through the use of our novel imaging technologies and animal models, we will answer timely questions that can lead to the development of treatments for lymphedema, chronic infections and lymphatic metastasis. (harvard.edu)
Microenvironment6
- We want to hijack them and turn them into factories for producing molecules that alter the tumor microenvironment so that it no longer nurtures the tumor. (health.am)
- CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)
- Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
- Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
- We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
- However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Tissues13
- Lymphatic tumors are abnormal growths that develop from the lymphatic vessels of the skin or subcutaneous tissue (tissues under the skin layer). (vcahospitals.com)
- Lymphatic vessels are a network of ducts and vessels that drain lymph (a fluid containing proteins and white blood cells) from body tissues and from lymph node to lymph node. (vcahospitals.com)
- In this early proof-of-concept study, the scientists have shown that they can target tumor blood vessels in mice without affecting healthy tissues. (health.am)
- Besides being in tissues, most white blood cells circulate throughout the body in the lymphatic system and blood vessels. (thehonestkitchen.com)
- Malignant, or cancerous, tumors crowd out healthy cells, interfere with body functions, and draw nutrients from body tissues. (webmd.com)
- Erosion of the tumor into blood vessels in adjacent tissues, or areas of necrosis within the tumor, can lead to hyphema or vitreous hemorrhage. (medscape.com)
- The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
- Some of that blood escapes from the system as it passes through tiny blood vessels called capillaries in the body tissues. (medlineplus.gov)
- The renal sinus is a cavity within the kidney containing the pelvis and calyces, adipose tissue, kidney vessels, nerves and lymphatic tissues, and is a continuation of the renal hilum. (evanewyork.net)
- The types of tumor tissues in the renal sinus are extensive, including fat, lymphatic, nerve and vascular tissues. (evanewyork.net)
- Lymphatic vessels are responsible for draining interstitial fluid from tissues and for transporting immune cells to lymph nodes to maintain the body's immune surveillance. (harvard.edu)
- Lymphatic vessels drain fluid called lymph from tissues throughout the body and return the fluid to the venous system through two collecting ducts. (msdmanuals.com)
- When lymphatic vessels are injured or obstructed, lymph fluid cannot drain and accumulates in tissues, causing swelling. (msdmanuals.com)
Benign8
- Some lymphatic tumors are benign ( lymphangioma ) and some are malignant ( lymphangiosarcoma ). (vcahospitals.com)
- These tumors (both benign and malignant) cause fluid to leak from the lymphatic vessels, therefore, the most commonly seen sign is edema (swelling) in the area of the tumor. (vcahospitals.com)
- In the case of benign lymphangioma, removal of the tumor and affected area often provides relief and no further treatment is necessary. (vcahospitals.com)
- Fractionated radiotherapy in the management of benign vascular tumors. (harvard.edu)
- Benign, or noncancerous, tumors do not spread to other parts of the body, and do not create new tumors. (webmd.com)
- This expansion gives rise to a small benign colon tumor (called a polyp or adenoma). (hopkinsmedicine.org)
- Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. (hopkinsmedicine.org)
- Lymphangioma is a benign hamartomatous tumor of lymphatic channels, with a marked predilection for the head and neck region, at submandibular and parotid area 2,10 . (bvsalud.org)
Invasion12
- Invasion of the shaft by a tumor originating from more distant sites may also be observed. (medscape.com)
- In vitro, SEMA3F inhibits tumor cell adhesion to fibronectin by inhibiting beta 1 integrin levels, inhibits tumor cell motility, and inhibits tumor cell invasion through matrigel. (harvard.edu)
- Generally, breast-conserving lumpectomy procedures remove single tumors less than five centimeters with no invasion of the chest wall. (smartimagebase.com)
- For larger tumors or multiple tumors with no chest wall invasion, the usual treatment is modified radical mastectomy. (smartimagebase.com)
- With larger tumors and chest wall invasion, a radical mastectomy removes the entire breast, lymphatics, and chest wall muscles. (smartimagebase.com)
- Histopathology of the testicle showed both a Sertoli cell tumor and seminoma with invasion of neoplastic Sertoli cells into blood vessels and lymphatics. (acvr.org)
- Surgical excision is generally curative, however given the evidence of vascular and lymphatic invasion in this case, post-operative chemotherapy was recommended. (acvr.org)
- These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
- We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
- Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
- Another theme is the role of epithelial-mesenchymal transition (EMT) in tumor cell invasion and epithelial remodeling in chronic inflammation. (ki.se)
- Upper extremity DVT occasionally occurs as part of superior vena cava (SVC) syndrome (compression or invasion of the superior vena cava by a tumor and causing symptoms such as facial swelling, dilated neck veins, and facial flushing) or results from a hypercoagulable state or subclavian vein compression at the thoracic outlet. (merckmanuals.com)
Metastases7
- Therapy is primarily guided by histopathological criteria as the depth of tumor penetration in the submucosa directly correlates with the probability of lymph node metastases. (researchgate.net)
- This patient series included those who underwent primary tumor resection, a bypass or a proctostomy and those who underwent the simultaneous resection of metastases with curative intent. (scirp.org)
- The stomach followed by colon are the two most common primary tumors to result in ovarian metastases , pursued by the breast, lung, and contralateral ovary. (radiopaedia.org)
- Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
- EVT801 provides the potential to specifically antagonise VEGFR3 to combine high efficacy both against the primary tumour and lymphatic-borne metastases with a highly favourable toxicology profile. (checkorphan.org)
- A study by Massachusetts General Hospital (MGH) investigators finds that, in mouse models, cancer cells from metastatic lymph nodes can escape into the circulation by invading nodal blood vessels, leading to the development of metastases in other parts of the body. (harvard.edu)
- Dr. Padera's research group recently published in Journal of the National Cancer Institute that the growth of metastases in lymph nodes does not require new blood vessels but instead takes advantage of existing blood vessels. (harvard.edu)
Endothelial7
- Recent advances have allowed us to use specific cell markers to distinguish between blood endothelial cells and lymphatic endothelial cells, so we can now see and study these very important networks in vitro and in vivo. (sciencedaily.com)
- Members of the vascular endothelial growth factor (VEGF) family, including VEGF-A and VEGF-C, stimulate the growth of blood vessels and lymphatic vessels. (harvard.edu)
- SEMA3F may inhibit angiogenesis and lymphangiogenesis by a novel mechanism, which is the repulsion of vascular and lymphatic endothelial cells (EC) expressing NRP2 similar to the way SEMA3F repels neurons. (harvard.edu)
- The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
- M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)
- Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)
- The association is strongest for mucin-secreting endothelial cell tumors such as bowel or pancreatic cancers. (merckmanuals.com)
Angiogenesis6
- Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
- Angiogenesis, the acquisition of new blood vessels, is an important step in tumor progression. (harvard.edu)
- The angiopoietin axis is involved in angiogenesis, a process used by the body to grow new blood vessels, which is also involved in the pathogenesis of several diseases including cancer. (amgen.com)
- In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
- The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)
- The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. (hopkinsmedicine.org)
Tissue14
- The human body is an incredibly designed machine, and mechanical processes such as those in the lymphatic system play major roles in maintaining healthy tissue and organs. (sciencedaily.com)
- A cystic growth originating from lymphatic tissue. (harvard.edu)
- Talimogene laherparepvec is an investigational oncolytic immunotherapy designed to selectively replicate in tumor tissue. (amgen.com)
- Talimogene laherparepvec is injected directly into tumor tissue and then replicates until the membrane of the cancer cells rupture, thereby destroying the cells, in a process known as cell lysis. (amgen.com)
- The virus that was contained in these cells is then released locally in the tumor tissue along with potential tumor antigens and GM-CSF, a white blood cell growth factor that the virus is engineered to express. (amgen.com)
- As tumors invade the surrounding tissue, cells may break off into a lymphatic vessel. (smartimagebase.com)
- The ocular tissue where these tumors arise, the uvea, is a densely pigmented layer that lies for the most part between the sclera and the retina. (medscape.com)
- Lymphatic circulation in breast tissue helps regulate the local fluid balance as well as filter out harmful substances. (medlineplus.gov)
- The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. (hopkinsmedicine.org)
- Most tumor tissue accumulates above the diaphragm and within inter-lobe furrows. (biketraffic.org)
- The renal hilum extends into a large cavity within the kidney occupied by the renal vessels, minor renal calyces, major renal calyces, renal pelvis and some adipose tissue. (evanewyork.net)
- Thus, lymphatics are important in maintaining both tissue fluid balance and proper function of the immune system. (harvard.edu)
- Most metastatic breast cancer is recurrent cancer , meaning it's cancer that came back after treatment and is affecting tissue and organs located far from the original breast cancer tumor . (clevelandclinic.org)
- The histological cuts were examined and stained in hematoxylin and eosin (HE), revealing lymphatic vessels of great diameter distributed in a conjunctive tissue poorly organized. (bvsalud.org)
Feeding the metastatic1
- The investigators showed that the blood vessels feeding the metastatic tumors glowed green but not vessels in the normal part of the ovary. (health.am)
Lymphangiogenesis4
- Therapies targeted against lymphangiogenesis, the growth of new lymphatic vessels, are beginning to be explored. (harvard.edu)
- Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)
- Absence of Lymphangiogenesis and Intratumoural Lymph Vessels in Human Metastatic Breast Cancer," The Journal of Pathology, Vol. 200, 2003, pp. 195-206. (scirp.org)
- Its primary activity is to inhibit lymphangiogenesis, the formation of new lymphatic vessels around a growing tumour. (checkorphan.org)
Abnormal5
- Building on their own previous work and others', the researchers engineered this viral vector to turn on its gene payload only in the abnormal blood vessels that help fuel and nurture tumor growth. (health.am)
- In theory, Arbeit pointed out, this approach could be applied to diseases other than cancer in which the blood vessels are abnormal, including conditions like Alzheimer's disease, multiple sclerosis or heart failure. (health.am)
- The superficial and deep lymphatic systems probably function independently, except in abnormal states, although there is evidence that they communicate near lymph nodes. (oncolink.org)
- A tumor is a mass composed of a cluster of such abnormal cells. (webmd.com)
- Tumors need blood vessels to survive, but the blood vessels are abnormal, twisted and leaky. (cancerquest.org)
Cancerous tumors2
- Mutations to these genes allow damaged cells to live and continue proliferating, resulting in the formation of cancerous tumors. (smartimagebase.com)
- The cancerous tumors usually have large cells called Reed-Sternberg cells. (rchsd.org)
Neoplasms1
- Given history, a Sertoli cell tumor is the primary differential diagnosis, with other testicular neoplasms considered less likely. (acvr.org)
Histologic Type1
- Choose the histologic type of the tumor. (mdanderson.org)
Form new tumors2
- Cancer cells can be taken to distant areas, where they can form new tumors. (cancerquest.org)
- Your lymph nodes and blood vessels carry fluid throughout your body, which makes it easy for breast cancer cells to find new places to settle and form new tumors. (clevelandclinic.org)
Organs3
- In mice, the researchers showed that they could inject the vector into the blood stream and that it accumulated in the tumor vasculature, largely avoiding the lung, kidney, heart and other healthy organs. (health.am)
- Anatomy of the lymph system showing the lymph vessels and lymph organs, including the lymph nodes, tonsils, thymus, spleen, and bone marrow. (oncolink.org)
- In fact, FTC tumors may spread easily to other organs. (medscape.com)
Cells40
- FNA involves taking a small needle with a syringe and suctioning a sample of cells directly from the tumor and placing them on a microscope slide. (vcahospitals.com)
- The viral vector Curiel, Arbeit and their colleagues developed contains a section of DNA called ROBO4 known to be switched on in the cells lining blood vessels within tumors. (health.am)
- The researchers used the viral vectors to deliver a gene that simply caused cells lining the blood vessels to glow green so they could see whether the vectors gathered in the tumors and bypassed healthy areas. (health.am)
- These mice had tumors in the kidneys and cancerous kidney cells in the skin. (health.am)
- Cells can sense mechanical stimuli, such as matrix stiffness, and this activates certain genes to promote lymphatic formation," said Hanjaya-Putra. (sciencedaily.com)
- In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
- There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
- This is intended to lead to the activation of a systemic immune response to kill tumor cells throughout the body. (amgen.com)
- Histamine -A nitrogen-based biochemical which makes blood vessels more permeable to the movements of white blood cells in order for the white blood cells to do their job in defending against invading bacteria, parasites, and viruses. (thehonestkitchen.com)
- Mast cell tumors (MCT, or mastocytoma) are collections of cancerous mast cells that form a mass-like lesion. (thehonestkitchen.com)
- Cancer occurs when cells that have lost their ability to stop dividing, grow in an out-of-control manner and form tumors. (thehonestkitchen.com)
- Krukenberg tumors are metastatic tumors to the ovary that contain well-defined histological characteristics (mucin-secreting "signet ring" cells) and usually originate in the gastrointestinal tract 4 . (radiopaedia.org)
- This mass of cells is a developing breast cancer tumor. (smartimagebase.com)
- Displaced tumor cells travel through the lymphatics and become metastatic tumors elsewhere. (smartimagebase.com)
- Its metastatic potential depends on the phenotype of the tumor cells, and it frequently disseminates before diagnosis. (medscape.com)
- Tumor-induced glaucoma may be produced by obstruction of outflow pathways by pigment cells (pigment dispersion syndrome), melanin-laden macrophages (melanomalytic glaucoma), or tumor cells. (medscape.com)
- Using mouse models, we validated the metastatic potential of tumor clusters was higher than single cells in vivo . (jcancer.org)
- Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)
- In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
- The metastasizing cells will proliferate in large numbers in situ and secrete proteolytic enzymes, such as the matrix metalloproteinases (MMPs), which degrade the extracellular matrix and blood vessel wall. (frontiersin.org)
- Hodgkin lymphoma (lim-FOE-muh) is a type of cancer that develops in the white blood cells of the lymphatic system, which is part of the immune system. (rchsd.org)
- Lymphatic vessels provide a highway along which invasive cancerous cells move to other parts of the body. (medlineplus.gov)
- Laser can stop cancer cells spreading - Tumour-zapping lasers have been deployed on another front against cancer by Finnish researchers. (scienceinpublic.com.au)
- They have found they can stop malignant cells from spreading by destroying the lymphatic vessels that act as highways for them. (scienceinpublic.com.au)
- Cancer cells often spread (or metastasize ) throughout the body by way of the bloodstream or lymphatic vessels to form tumors in new locations beyond the primary site of origin. (agemed.org)
- Indicate whether tumor cells were present in blood vessels or lymphatic structures. (mdanderson.org)
- Lung tumors originate from cells lining the airways and are also called bronchogenic cancers. (biketraffic.org)
- The formation of a tumor occurs as a result of the transformation of cells of normal respiratory epithelium as a result of disorders (in most mutations) of genes important for cell growth and its division. (biketraffic.org)
- Pleural mesothelioma (malignant mesothelioma) is a rare malignant tumor originating from the superficial cells of the pleural lining. (biketraffic.org)
- Lymphatic vessels also facilitate the dissemination of cancer cells from a primary tumor to regional lymph nodes. (harvard.edu)
- We can monitor the lymphatic vessels in the tumor margin, observe tumor cells moving in lymphatic vessels, measure lymph flow and quantify the number of tumor cells that arrive in the draining lymph node. (harvard.edu)
- Blood vessels provide nutrients and oxygen to cells. (cancerquest.org)
- Cancer cells can invade blood (and lymphatic) vessels. (cancerquest.org)
- Once in a vessel, cancer cells can move around the body. (cancerquest.org)
- The cancer cells in a tumor are similar, but not exactly the same. (cancerquest.org)
- These cells may travel through your bloodstream and lymphatic system , using your lymph nodes and blood vessels to carry cancer to other areas of your body. (clevelandclinic.org)
- Breast cancer cells may start forming new tumors right away, eventually causing symptoms or signs that show breast cancer has spread. (clevelandclinic.org)
- An incisional biopsy was performed, whose anatomopathological study evidenced an intralymphatic lesion, with prominent papillary formations and vascular axes lined by rounded and hyperchromatic cells, projecting into the lumen (hobnail cells), compatible with papillary intralymphatic angioendothelioma - Dabska tumor ( Figs. 3 and 4 ). (anaisdedermatologia.org.br)
- In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
- Thus, important functions of the lymphatic system are to remove damaged cells from the body and to provide protection against the spread of infection and cancer. (msdmanuals.com)
Primary tumors1
- In dogs diagnosed with testicular neoplasia, anywhere from 4-20% of cases will have multiple primary tumors, as seen in this case. (acvr.org)
Lymphangioma3
- Introduction: Lymphangioma is a change of lymphatic vessels that frequently affects the head and neck region. (bvsalud.org)
- It can be classified according to the size of vessels into three types: capillary, cavernous, and cystic lymphangioma. (bvsalud.org)
- The lesion is classified according to the vessels diameter into: capillary or microcystic, cavernous or macrocystic, and cystic or hygroma lymphangioma 7,13 . (bvsalud.org)
Lymphocytes2
- 4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
- Lymph (clear fluid) and lymphocytes travel through the lymph vessels and into the lymph nodes where the lymphocytes destroy harmful substances. (oncolink.org)
Peritoneal cavity2
- However, several mechanisms have been proposed, such as through lymphatic channels, blood vessels, and peritoneal cavity 9 . (radiopaedia.org)
- [ 1 , 2 ] The production of chylous ascites following abdominal aortic surgery is the result of a lymphatic fistula of traumatic origin between the cisterna chyli or adjacent major lymphatic trunks and the peritoneal cavity. (medscape.com)
Lymphedema8
- Lymphedema occurs when disruption of normal lymphatic drainage leads to accumulation of protein-rich lymph fluid in the interstitial space. (oncolink.org)
- This summary reviews the anatomy of the lymphatic system, the pathophysiology of lymphedema secondary to cancer, and epidemiology. (oncolink.org)
- Predictably, disruptions of the lymphatic system lead to lymphedema and the conditions for chronic infections. (harvard.edu)
- My research group looks to understand the mechanisms behind the growth, maturation and function of lymphatic vessels and how these mechanisms can contribute to the pathogenesis of lymphedema, chronic infections and cancer dissemination. (harvard.edu)
- In addition, we have begun to study the pathogenesis of lymphedema by unraveling the molecular underpinnings of autonomous contraction of collecting lymphatic vessels using a novel animal model. (harvard.edu)
- If ending a kind of lymphedema called lymphatic you've ever been sick and felt a swelling or tenderness in filariasis. (medlineplus.gov)
- your neck or armpits (where some of your major lymph lymphedema caused by microscopic worms nodes are), you've felt your lymphatic system at work. (medlineplus.gov)
- Primary lymphedema occurs when the lymphatic billion people worldwide. (medlineplus.gov)
Cancer12
- The reason why a particular pet may develop this, or any tumor or cancer, is not straightforward. (vcahospitals.com)
- But now, investigators at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine say they have designed a "targetable injectable vector" - a deactivated virus that homes in on the inner lining of tumor blood vessels and does not get stuck in the liver, a problem that has plagued past attempts. (health.am)
- He looks at how to restore dysfunctional lymphatic networks, which are associated with a wide range of diseases, including cancer, cardiovascular disease, diabetes, neurological conditions and metabolic syndromes. (sciencedaily.com)
- She will be studying lymphatic vessel formation in vivo in wound and cardiac injury models with Kari Alitalo, a global leader in the research of lymphatic vessels and translational cancer biology. (sciencedaily.com)
- Another common and potentially deadly type of cancer are Mast Cell Tumors. (thehonestkitchen.com)
- The lymphatic system can play a very worrisome role in the spread of breast cancer. (medlineplus.gov)
- But the breast's lymphatic system can also spread diseases such as cancer through the body. (medlineplus.gov)
- High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
- Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation," Cancer Research, Vol. 60, No. 16, 2000, pp. 4324-4327. (scirp.org)
- We will test whether cancer or bacterial infections invoke similar regulatory dysfunction of lymphatic contraction. (harvard.edu)
- Occult cancers may be present in patients with apparently idiopathic DVT, but extensive workup of patients for tumors is not recommended unless patients have major risk factors for cancer or symptoms suggestive of an occult cancer. (merckmanuals.com)
- The most common thyroid tumor to develop after exposure to radiation is papillary thyroid cancer. (medscape.com)
Common primary malignant2
- Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)
- Choroidal melanoma is the most common primary malignant intraocular tumor and the second most common type of primary malignant melanoma in the body. (medscape.com)
Extracellular matrix1
- and Brian Coe, class of '19 -- have demonstrated how extracellular matrix stiffness affects lymphatic vessel function. (sciencedaily.com)
Carcinomas2
- There are a variety of metastatic carcinomas to the ovary that can mimic primary ovarian tumors 4 . (radiopaedia.org)
- The great majority of Krukenberg tumors are signet ring cell carcinomas arising in the stomach. (radiopaedia.org)
Antigens1
- Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)
Bloodstream2
- The network of vessels pass through a series of filtering lymph nodes (glands) and eventually into the bloodstream. (vcahospitals.com)
- and the Laboratory of Parasitic Diseases at The lymphatic system works to move a clear, watery, the National Institute of Allergy and Infectious protein-rich fluid called lymph into your bloodstream. (medlineplus.gov)
Disruption1
- Thus disruption of lymphatic function has consequences for the overall immune function. (harvard.edu)
Therapeutic4
- Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
- Goss, P. E. & Chambers, A. F. Does tumour dormancy offer a therapeutic target? (nature.com)
- Penile tumors present a difficult diagnostic and therapeutic issue, mainly because of their psychological implications. (medscape.com)
- Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors . (hopkinsmedicine.org)
Capillaries2
- Lymphatic vessels, located throughout the body, are larger than capillaries (the smallest blood vessels, which connect arteries and veins), and most are smaller than the smallest veins. (msdmanuals.com)
- Most of the fluid is reabsorbed into the capillaries and the rest is drained into the lymphatic vessels, which eventually return it to the veins. (msdmanuals.com)
Lymph fluid1
- Weight loss and exercise to help lymphatic vessels move and stiffness trapped lymph fluid. (medlineplus.gov)
Cancers3
- Very few tumors and cancers have a single known cause. (vcahospitals.com)
- Most cancers form tumors, but not all tumors are cancerous. (webmd.com)
- Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. (hopkinsmedicine.org)
Cisterna chyli1
- The lumbar lymphatic trunk joins the intestinal lymphatic trunk and cisterna chyli to form the thoracic duct, which empties into the left subclavian vein. (oncolink.org)
Vivo1
- In vivo, mock-transfected tumors are circumscribed with many large, open-lumened lymphatic vessels and contain intratumoral lymphatic vessels as well, while tumors overexpressing SEMA3F do not contain lymphatic vessels or have dilated surrounding lymphatics. (harvard.edu)
Treat malignant1
- See The Case of the Middle-Aged Woman with Sudden Unilateral Vision Loss , a Critical Images slideshow, to help identify and treat malignant intraocular tumors. (medscape.com)
Fluid2
- Both types are soft, poorly defined masses that may cause fluid to leak out from lymphatic vessels. (vcahospitals.com)
- Mar. 20, 2023 When lymphatic vessels fail, typically their ability to pump out the fluid is compromised. (sciencedaily.com)
Hematogenous1
- Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)
Obstruction1
- It is often used for detecting ascites, biliary or renal obstruction, or pelvic tumors, and is also useful for guiding biopsies. (oncolink.org)
Growths1
- Tumors of skin and bone growths appear as they age typically in early childhood. (wikipedia.org)
Disorders1
- Vascular anomalies are abnormalities or disorders of blood vessels or lymphatic vessels in various parts of the body. (nuh.com.sg)
Ducts2
- The lymphatic vessels drain into collecting ducts, which empty their contents into the two subclavian veins, located under the collarbones. (msdmanuals.com)
- 13,14 ), and they have larger alveoli and The scientific and regulatory communities increase in lung tumors, although soot accu- alveolar ducts than rats ( 15 ). (cdc.gov)
Affects1
- Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. (anaisdedermatologia.org.br)
Lung2
- When it comes to tumors from large bronchi, we are talking about centrally located tumors (located near the mediastinum), while tumors from small bronchioles are usually in a "peripheral" position, i.e. located on the periphery of the lung. (biketraffic.org)
- The growing tumor squeezes the lung and limits its mobility. (biketraffic.org)
Breast3
- Lymph nodes and vessels surround the breast radially and drain to axillary lymphatics. (smartimagebase.com)
- No woman is too young to know that regular breast self-examinations can help to catch tumors earlier in their growth, hopefully before they spread or metastasize. (medlineplus.gov)
- Indicate whether tumor was located in more than one location in the breast. (mdanderson.org)
System13
- He studies the lymphatic system -- the part of the immune system that rids the body of toxins and other unwanted materials. (sciencedaily.com)
- Traditionally, medical students spent hours studying the cardiovascular system, but not as much emphasis was placed on the lymphatic system," said Hanjaya-Putra. (sciencedaily.com)
- The human lymphatic system generally includes superficial or primary lymphatic vessels that form a complex dermal network of capillary-like channels. (oncolink.org)
- An intramuscular system of lymphatic vessels that parallels the deep arteries and drains the muscular compartment, joints, and synovium also exists. (oncolink.org)
- lymph nodes and then spreads from one part of the lymphatic system to another. (rchsd.org)
- That system is the lymphatic system. (medlineplus.gov)
- EVT801 also has marked activity on the immune system within the tumour and may therefore enhance the activity of immuno-oncology therapies. (checkorphan.org)
- In order to study the role of the lymphatic system in a variety of disease states, we have developed novel animal models which mimic certain aspects of human disease. (harvard.edu)
- Like the venous system, the lymphatic system transports fluids throughout the body. (msdmanuals.com)
- Tumors that press against lymph nodes condition--once the lymph system is damaged, it can create blockages, and radiation can affect lymph nodes cannot be repaired. (medlineplus.gov)
- something upsets the lymphatic system. (medlineplus.gov)
- The lymphatic on the study of parasites--small organisms system is part of the body's immune system and includes that survive by living off the human body. (medlineplus.gov)
- Sometimes, though, the lymphatic system gets blocked swelling in the limbs. (medlineplus.gov)
Histological3
- LMVD correlated significantly with tumour size (p=0.003), histological grade (p=0.046), lymph node status (p=0.030). (scirp.org)
- There was a strong association between tumour size (p=0.142), histological grade (p=0.066) though the correlation was not statistically significant. (scirp.org)
- We describe a case of a young woman presenting with a plantar lesion, for 9 months and histological diagnosis of Dabska tumor. (anaisdedermatologia.org.br)
Suppressor2
- In contrast to meningiomas arising in neurofibromatosis type 2 patients missing an NF2 gene coding for the Merlin tumor suppressor protein, the researchers found that more than one-third of the meningiomas fell into a Merlin-intact group with the most favorable clinical outcomes and vulnerability to cytotoxic therapy. (genomeweb.com)
- This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. (hopkinsmedicine.org)
Phenotypes1
- Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. (hopkinsmedicine.org)
Clinical2
- What are the clinical signs of lymphatic tumors? (vcahospitals.com)
- EVT801 is a pre-clinical-stage, orally available, small molecule inhibitor of the lymphatic growth factor receptor VEGFR3, originally developed within Evotec's partnership with Sanofi. (checkorphan.org)
Metabolically1
- Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)
Testicular2
- citation needed] Affected individuals are at increased risk for developing certain tumors including unilateral ovarian cystadenomas, testicular tumors, meningiomas, and monomorphic adenomas of the parotid gland. (wikipedia.org)
- Testicular torsion is generally associated with neoplasia in dogs, with increased risk with large tumors. (acvr.org)
Therapies aimed1
- But unlike most therapies aimed at tumor vasculature, the goal is not to destroy the cancer's blood supply. (health.am)
Filariasis2
- Wuchereria bancrofti, the causative agent of lymphatic filariasis. (medlineplus.gov)
- lymphatic filariasis a problem of the past. (medlineplus.gov)
Stiffness1
- We used hydrogels made from hyaluronic acid (a natural sugar molecule) to enhance the cell-binding motif with appropriate mechanical stimuli (matrix stiffness) in a 2D model of lymphatic vessels and successfully stimulated new lymphatic vessel formations. (sciencedaily.com)
Diagnosis1
- These samples are not always valuable for diagnosis and instead a biopsy (surgical excision of a piece of the tumor) is required. (vcahospitals.com)